Page last updated: 2024-11-03

propofol and Coronary Heart Disease

propofol has been researched along with Coronary Heart Disease in 30 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"It is skeptical about cardioprotective property of sevoflurane in patients undergoing noncardiac surgery, especially in the elderly patients with coronary heart disease."9.24Randomized comparison of sevoflurane versus propofol-remifentanil on the cardioprotective effects in elderly patients with coronary heart disease. ( Feng, X; Lin, W; Shen, S; Sun, J; Wang, H; Zhang, Y, 2017)
" After exclusion of potential causes for this phenomenon, it was attributed to perioperative intravenous propofol infusion causing propofol infusion syndrome."7.75Propofol infusion syndrome in adult cardiac surgery. ( Balacumaraswami, L; Ilyas, MI; Palin, C; Ratnatunga, C, 2009)
"003 mg/kg fentanyl the patients received the induction agent in the above-mentioned dosage within 40 s followed by 0."6.66[Comparative hemodynamic study of anesthesia induction with propofol (Diprivan), thiopental, methohexital, etomidate and midazolam in patients with coronary disease]. ( Boldt, J; Börner, U; Hempelmann, G; Kling, D; Laubenthal, H, 1987)
"Fentanyl was also associated with a significant decrease in heart rate (16%) resulting in a decrease in CI, whereas stroke index and end diastolic volume did not change."5.27Left ventricular function during propofol and fentanyl anesthesia in patients with coronary artery disease: assessment with a radionuclide approach. ( Cozian, AY; Farinotti, R; Hélias, JH; Juge, CM; Lepage, JY; Pinaud, ML; Souron, RJ, 1988)
"It is skeptical about cardioprotective property of sevoflurane in patients undergoing noncardiac surgery, especially in the elderly patients with coronary heart disease."5.24Randomized comparison of sevoflurane versus propofol-remifentanil on the cardioprotective effects in elderly patients with coronary heart disease. ( Feng, X; Lin, W; Shen, S; Sun, J; Wang, H; Zhang, Y, 2017)
"Comparison of the length of mechanical ventilation and postoperative complications after coronary surgery in elderly patients anaesthetised with propofol associated with either alfentanil or remifentanil."5.11[Continuous infusion of remifentanil and target-controlled infusion of propofol for coronary surgery in elderly patients: comparison with continuous infusion of remifentanil and propofol]. ( Blin, D; Chavanon, O; Durand, M; Gardellin, M; Girardet, P; Maitrasse, B; Robin, S, 2004)
" After exclusion of potential causes for this phenomenon, it was attributed to perioperative intravenous propofol infusion causing propofol infusion syndrome."3.75Propofol infusion syndrome in adult cardiac surgery. ( Balacumaraswami, L; Ilyas, MI; Palin, C; Ratnatunga, C, 2009)
"003 mg/kg fentanyl the patients received the induction agent in the above-mentioned dosage within 40 s followed by 0."2.66[Comparative hemodynamic study of anesthesia induction with propofol (Diprivan), thiopental, methohexital, etomidate and midazolam in patients with coronary disease]. ( Boldt, J; Börner, U; Hempelmann, G; Kling, D; Laubenthal, H, 1987)
"Thiopental, however, was associated with a dose-dependent decrease in systolic shortening, which was significantly greater in the ischemic segment."1.28Influence of thiopental, etomidate, and propofol on regional myocardial function in the normal and acute ischemic heart segment in dogs. ( Adriaensen, HF; De Hert, SG; Vermeyen, KM, 1990)
"Fentanyl was also associated with a significant decrease in heart rate (16%) resulting in a decrease in CI, whereas stroke index and end diastolic volume did not change."1.27Left ventricular function during propofol and fentanyl anesthesia in patients with coronary artery disease: assessment with a radionuclide approach. ( Cozian, AY; Farinotti, R; Hélias, JH; Juge, CM; Lepage, JY; Pinaud, ML; Souron, RJ, 1988)
"Propofol was used at a dose of 2 mg X kg-1."1.27[Hemodynamic effects of propofol used alone for the induction of anesthesia]. ( Jullian-Papouin, H; Manelli, JC; Paulin, M; Roquebert, PO, 1987)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199011 (36.67)18.7374
1990's11 (36.67)18.2507
2000's7 (23.33)29.6817
2010's1 (3.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, Y1
Lin, W1
Shen, S1
Wang, H1
Feng, X1
Sun, J1
Ilyas, MI1
Balacumaraswami, L1
Palin, C1
Ratnatunga, C1
Hiraoka, H1
Yamamoto, K1
Okano, N1
Morita, T1
Goto, F1
Horiuchi, R1
Gardellin, M1
Durand, M1
Maitrasse, B1
Chavanon, O1
Robin, S1
Blin, D1
Girardet, P1
Cillo, JE1
Finn, R1
Al-Khudhairi, D1
Gordon, G1
Morgan, M1
Whitwam, JG1
Duthie, DJ1
Stevens, JJ1
Doyle, AR1
Baddoo, HH1
Marty, J1
Higgins, TL1
Yared, JP1
Estafanous, FG1
Coyle, JP1
Ko, HK1
Goodale, DB1
Lischke, V1
Wilke, HJ1
Probst, S1
Behne, M1
Kessler, P1
Mayer, N1
Legat, K1
Weinstabl, C1
Zimpfer, M1
Gerhardt, MA1
Grichnik, KP1
Kakinohana, M1
Saitoh, T1
Okuda, Y1
Kazmaier, S1
Hanekop, GG1
Buhre, W1
Weyland, A1
Busch, T1
Radke, OC1
Zoelffel, R1
Sonntag, H3
Pittarello, D1
Bonato, R1
Armellin, G1
Sorbara, C1
Haessler, R1
Madler, C1
Klasing, S1
Schwender, D1
Peter, K1
De Hert, SG2
Lepage, JY4
Pinaud, ML2
Helias, JH2
Cozian, AY2
Le Normand, Y1
Souron, RJ2
Kavanagh, BP1
Ryan, MP1
Cunningham, AJ1
Vermeyen, KM2
Adriaensen, HF1
Dupuy, P1
Pery, N1
Boisson, A1
Sirodot, M1
Langeron, O1
Payen, D1
Pinaud, M2
Hélias, J2
Cozian, A2
Juge, C2
Souron, R2
Stephan, H2
Seyde, WC1
Henze, T1
Textor, J1
Juge, CM1
Farinotti, R1
Kling, D1
Laubenthal, H1
Börner, U1
Boldt, J1
Hempelmann, G1
Schenk, HD1
Kettler, D1
Khambatta, HJ1
Paulin, M1
Jullian-Papouin, H1
Roquebert, PO1
Manelli, JC1
Erpels, FA1
Janssen, LA1
Beeckman, CP1
Hanegreefs, GH1
Patrick, MR1
Blair, IJ1
Feneck, RO1
Sebel, PS1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"Haemodynamic Stability During Induction of General Anesthesia With Propofol and Remifentanil: A Randomized, Controlled, Double-blind Study Comparing Equipotent Prophylactic Doses of Ephedrine, Phenylephrine, Norepinephrine vs Placebo."[NCT03864094]Phase 499 participants (Anticipated)Interventional2022-03-15Recruiting
"Hemodynamic Stability During Induction of General Anesthesia With Propofol and Remifentanil: A Randomized, Controlled, Double-blind Study Comparing Medium and Low Remifentanil Doses."[NCT03861377]Phase 499 participants (Actual)Interventional2020-06-09Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

9 trials available for propofol and Coronary Heart Disease

ArticleYear
Randomized comparison of sevoflurane versus propofol-remifentanil on the cardioprotective effects in elderly patients with coronary heart disease.
    BMC anesthesiology, 2017, Aug-11, Volume: 17, Issue:1

    Topics: Aged; Aged, 80 and over; Anesthetics, Inhalation; Anesthetics, Intravenous; Cardiac Output; Cardioto

2017
Changes in drug plasma concentrations of an extensively bound and highly extracted drug, propofol, in response to altered plasma binding.
    Clinical pharmacology and therapeutics, 2004, Volume: 75, Issue:4

    Topics: Adult; Aged; Analysis of Variance; Anesthetics, Intravenous; Biological Availability; Blood Proteins

2004
[Continuous infusion of remifentanil and target-controlled infusion of propofol for coronary surgery in elderly patients: comparison with continuous infusion of remifentanil and propofol].
    Annales francaises d'anesthesie et de reanimation, 2004, Volume: 23, Issue:10

    Topics: Aged; Anesthetics, Intravenous; Coronary Disease; Humans; Infusions, Intravenous; Orthopedic Procedu

2004
Propofol versus midazolam for intensive care unit sedation after coronary artery bypass grafting.
    Critical care medicine, 1994, Volume: 22, Issue:9

    Topics: Adult; Aged; Blood Pressure; Conscious Sedation; Coronary Artery Bypass; Coronary Disease; Drug Admi

1994
Prolongation of the QT-interval during induction of anesthesia in patients with coronary artery disease.
    Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:2

    Topics: Anesthesia, Intravenous; Blood Pressure; Coronary Disease; Electrocardiography; Etomidate; Female; F

1994
[Alterations in left ventricular-arterial coupling and mechanical efficiency produced by remifentanil during cardiac anesthesia].
    Minerva anestesiologica, 2001, Volume: 67, Issue:3

    Topics: Aged; Anesthetics, Intravenous; Aorta; Cardiovascular Agents; Combined Modality Therapy; Coronary Ar

2001
Left ventricular performance during propofol or methohexital anesthesia: isotopic and invasive cardiac monitoring.
    Anesthesia and analgesia, 1991, Volume: 73, Issue:1

    Topics: Aged; Anesthesia, Intravenous; Coronary Disease; Gated Blood-Pool Imaging; Hemodynamics; Humans; Met

1991
[Comparative hemodynamic study of anesthesia induction with propofol (Diprivan), thiopental, methohexital, etomidate and midazolam in patients with coronary disease].
    Der Anaesthesist, 1987, Volume: 36, Issue:10

    Topics: Anesthesia, General; Anesthetics; Clinical Trials as Topic; Coronary Artery Bypass; Coronary Disease

1987
A comparison of the haemodynamic effects of propofol ('Diprivan') and thiopentone in patients with coronary artery disease.
    Postgraduate medical journal, 1985, Volume: 61 Suppl 3

    Topics: Anesthesia, Intravenous; Coronary Disease; Female; Hemodynamics; Humans; Male; Middle Aged; Phenols;

1985

Other Studies

21 other studies available for propofol and Coronary Heart Disease

ArticleYear
Propofol infusion syndrome in adult cardiac surgery.
    The Annals of thoracic surgery, 2009, Volume: 87, Issue:1

    Topics: Acidosis, Lactic; Aged; Anesthetics, Intravenous; Blood Chemical Analysis; Cardiopulmonary Bypass; C

2009
Hemodynamics in elderly coronary artery disease patients undergoing propofol sedation.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2006, Volume: 64, Issue:9

    Topics: Age Factors; Aged; Aged, 80 and over; Analgesics, Opioid; Anesthesia, Dental; Anesthetics, Intraveno

2006
Acute cardiovascular changes following disoprofol. Effects in heavily sedated patients with coronary artery disease.
    Anaesthesia, 1982, Volume: 37, Issue:10

    Topics: Anesthesia, Intravenous; Anesthetics; Coronary Disease; Hemodynamics; Humans; Male; Middle Aged; Phe

1982
Remifentanil and coronary artery surgery.
    Lancet (London, England), 1995, Mar-11, Volume: 345, Issue:8950

    Topics: Analgesics, Opioid; Coronary Disease; Drug Combinations; Humans; Length of Stay; Pancuronium; Piperi

1995
[Coronary patient undergoing non cardiac surgery and Diprivan].
    Annales francaises d'anesthesie et de reanimation, 1994, Volume: 13, Issue:4

    Topics: Anesthesia, Intravenous; Coronary Disease; Hemodynamics; Humans; Monitoring, Intraoperative; Propofo

1994
Effects of propofol on the function of normal, collateral-dependent, and ischemic myocardium.
    Anesthesia and analgesia, 1993, Volume: 76, Issue:1

    Topics: Animals; Collateral Circulation; Coronary Disease; Dogs; Female; Heart; Hemodynamics; Injections, In

1993
Early extubation and neurologic examination following combined carotid endarterectomy and coronary artery bypass grafting using remifentanil.
    Journal of clinical anesthesia, 1998, Volume: 10, Issue:3

    Topics: Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, Intravenous; Blood Pressure; Carotid St

1998
[Anesthetic management of an emergency surgery for panperitonitis during an asthmatic attack].
    Masui. The Japanese journal of anesthesiology, 2000, Volume: 49, Issue:3

    Topics: Aged; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Inhalation; Coronary Disease; Duodenal

2000
Myocardial consequences of remifentanil in patients with coronary artery disease.
    British journal of anaesthesia, 2000, Volume: 84, Issue:5

    Topics: Aged; Anesthetics, Intravenous; Blood Pressure; Coronary Circulation; Coronary Disease; Heart Rate;

2000
Myocardial consequences of remifentanil in patients with coronary artery disease.
    British journal of anaesthesia, 2000, Volume: 84, Issue:5

    Topics: Aged; Anesthetics, Intravenous; Blood Pressure; Coronary Circulation; Coronary Disease; Heart Rate;

2000
Myocardial consequences of remifentanil in patients with coronary artery disease.
    British journal of anaesthesia, 2000, Volume: 84, Issue:5

    Topics: Aged; Anesthetics, Intravenous; Blood Pressure; Coronary Circulation; Coronary Disease; Heart Rate;

2000
Myocardial consequences of remifentanil in patients with coronary artery disease.
    British journal of anaesthesia, 2000, Volume: 84, Issue:5

    Topics: Aged; Anesthetics, Intravenous; Blood Pressure; Coronary Circulation; Coronary Disease; Heart Rate;

2000
Propofol/fentanyl versus etomidate/fentanyl for the induction of anesthesia in patients with aortic insufficiency and coronary artery disease.
    Journal of cardiothoracic and vascular anesthesia, 1992, Volume: 6, Issue:2

    Topics: Adult; Anesthesia, General; Aortic Valve Insufficiency; Coronary Disease; Etomidate; Female; Fentany

1992
Study on the effects of six intravenous anesthetic agents on regional ventricular function in dogs (thiopental, etomidate, propofol, fentanyl, sufentanil, alfentanil).
    Acta anaesthesiologica Belgica, 1991, Volume: 42, Issue:1

    Topics: Alfentanil; Animals; Coronary Disease; Dogs; Etomidate; Female; Fentanyl; Hemodynamics; Infusions, I

1991
Myocardial contractility and ischaemia in the isolated perfused rat heart with propofol and thiopentone.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1991, Volume: 38, Issue:5

    Topics: Animals; Coronary Disease; Magnesium; Male; Myocardial Contraction; Myocardium; Perfusion; Potassium

1991
Influence of thiopental, etomidate, and propofol on regional myocardial function in the normal and acute ischemic heart segment in dogs.
    Anesthesia and analgesia, 1990, Volume: 70, Issue:6

    Topics: Animals; Coronary Disease; Dogs; Etomidate; Female; Heart; Hemodynamics; Infusions, Intravenous; Mal

1990
[Myocardial depression induced by propofol (P) is not of ischemic origin].
    Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8 Suppl

    Topics: Adult; Aged; Anesthesia; Anti-Arrhythmia Agents; Coronary Circulation; Coronary Disease; Heart Ventr

1989
[Comparison of the effects of propofol and brietal on cardiac performance in coronary disease. Gamma-angioscintigraphy].
    Annales francaises d'anesthesie et de reanimation, 1989, Volume: 8 Suppl

    Topics: Aged; Coronary Disease; Heart; Hemodynamics; Humans; Methohexital; Middle Aged; Propofol; Radionucli

1989
[Energy and amino acid metabolism in the human brain under Disoprivan anesthesia with various paCO2 values].
    Der Anaesthesist, 1988, Volume: 37, Issue:5

    Topics: Amino Acids; Anesthesia, General; Anesthetics; Blood Glucose; Brain; Carbon Dioxide; Cerebrovascular

1988
Left ventricular function during propofol and fentanyl anesthesia in patients with coronary artery disease: assessment with a radionuclide approach.
    Anesthesia and analgesia, 1988, Volume: 67, Issue:10

    Topics: Aged; Aged, 80 and over; Anesthesia; Coronary Disease; Drug Combinations; Female; Fentanyl; Heart; H

1988
Effects of propofol on cardiovascular dynamics, myocardial blood flow and myocardial metabolism in patients with coronary artery disease.
    British journal of anaesthesia, 1986, Volume: 58, Issue:9

    Topics: Adult; Anesthesia, Intravenous; Anesthetics; Coronary Artery Bypass; Coronary Circulation; Coronary

1986
[Hemodynamic effects of propofol used alone for the induction of anesthesia].
    Annales francaises d'anesthesie et de reanimation, 1987, Volume: 6, Issue:4

    Topics: Aged; Anesthesia, General; Anesthetics; Blood Pressure; Coronary Disease; Female; Hemodynamics; Huma

1987
[Effect of propofol on left ventricular function in the coronary patient. Combined isotopic and hemodynamic studies].
    Annales francaises d'anesthesie et de reanimation, 1987, Volume: 6, Issue:4

    Topics: Aged; Anesthetics; Cineangiography; Coronary Disease; Heart; Heart Ventricles; Hemodynamics; Humans;

1987
Propofol-fentanyl anaesthesia for coronary bypass surgery in patients with good left ventricular function.
    British journal of anaesthesia, 1987, Volume: 59, Issue:9

    Topics: Adult; Aged; Anesthesia, Intravenous; Anesthetics; Coronary Artery Bypass; Coronary Disease; Female;

1987
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