propofol and Age-Related Memory Disorders
propofol has been researched along with Age-Related Memory Disorders in 36 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
" We found that high-dose propofol anesthesia significantly alleviated spatial memory loss." | 7.91 | High-dose Propofol Anesthesia Reduces the Occurrence of Postoperative Cognitive Dysfunction via Maintaining Cytoskeleton. ( An, J; Cao, L; Cope, D; Eastwood, D; Fang, Q; Lin, S; Ma, J; Qian, X; Williams, J; Yuan, Z, 2019) |
"Neuroprotective effect of propofol against cerebral ischemia injury was widely investigated." | 7.83 | Propofol Prevents Hippocampal Neuronal Loss and Memory Impairment in Cerebral Ischemia Injury Through Promoting PTEN Degradation. ( Chen, X; Du, YM; Liu, D; Wang, YL; Xu, F, 2016) |
"3 mg/kg ketamine and then underwent ECT under propofol anesthesia, and a control group, which received isovolumetric placebo (normal saline) and then underwent ECT under propofol anesthesia." | 5.24 | Effect of Low Dose of Ketamine on Learning Memory Function in Patients Undergoing Electroconvulsive Therapy-A Randomized, Double-Blind, Controlled Clinical Study. ( Chen, J; Chen, Q; Hao, X; Li, X; Luo, Q; Meng, H; Min, S; Peng, L, 2017) |
"To investigate the effects of ginsenosides on the memory impairment in Sprague-Dawley rats (SD rats) after anesthesia through the administration of propofol SPF, SD rats were randomly divided into four groups: control group (Group I), propofol-treated group (Group II), low dose of ginsenosides-treated group (Group III) and high dose of ginsenosides-treated group (Group IV)." | 4.12 | Effects of ginsenosides on memory impairment in propofol-anesthetized rats. ( Chen, G; Liu, X; Xie, D; Xu, ZL; Ying, Y; Zhang, J, 2022) |
" We found that high-dose propofol anesthesia significantly alleviated spatial memory loss." | 3.91 | High-dose Propofol Anesthesia Reduces the Occurrence of Postoperative Cognitive Dysfunction via Maintaining Cytoskeleton. ( An, J; Cao, L; Cope, D; Eastwood, D; Fang, Q; Lin, S; Ma, J; Qian, X; Williams, J; Yuan, Z, 2019) |
"BACKGROUND The present study explored the effects of propofol on hippocampal autophagy and synaptophysin in depression-model rats undergoing electroconvulsive shock (ECS)." | 3.83 | Propofol Mitigates Learning and Memory Impairment After Electroconvulsive Shock in Depressed Rats by Inhibiting Autophagy in the Hippocampus. ( Hao, XC; Li, P; Luo, J; Lv, F; Min, S; Wei, K, 2016) |
"Neuroprotective effect of propofol against cerebral ischemia injury was widely investigated." | 3.83 | Propofol Prevents Hippocampal Neuronal Loss and Memory Impairment in Cerebral Ischemia Injury Through Promoting PTEN Degradation. ( Chen, X; Du, YM; Liu, D; Wang, YL; Xu, F, 2016) |
"Propofol was added intraperitoneally to the mice from 7th day of insulin/saline treatment, and general anesthesia was induced and maintained for 2 hours/day for 5 consecutive days." | 1.51 | Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice. ( Huang, F; Ke, D; Li, X; Liang, Z; Liu, R; Run, X; Wang, JZ; Wang, Q; Wang, X; Wei, Z; Zeng, K; Zhang, B, 2019) |
"The isoflurane anaesthesia treatment increased the escape latency contrast to propofol anaesthesia group." | 1.38 | Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level. ( Feng, C; Jia, X; Wang, H; Wang, Y; Wu, A; Xu, Z; Yue, Y, 2012) |
Research
Studies (36)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (2.78) | 18.2507 |
2000's | 5 (13.89) | 29.6817 |
2010's | 27 (75.00) | 24.3611 |
2020's | 3 (8.33) | 2.80 |
Authors
Authors | Studies |
---|---|
Xu, ZL | 1 |
Chen, G | 1 |
Liu, X | 1 |
Xie, D | 1 |
Zhang, J | 2 |
Ying, Y | 1 |
Sun, L | 1 |
Niu, K | 2 |
Guo, J | 2 |
Tu, J | 1 |
Ma, B | 1 |
An, J | 2 |
Ma, J | 1 |
Williams, J | 1 |
Eastwood, D | 1 |
Lin, S | 1 |
Qian, X | 1 |
Fang, Q | 1 |
Cope, D | 1 |
Yuan, Z | 1 |
Cao, L | 1 |
Qin, JL | 1 |
Lu, GF | 1 |
Williams, JP | 1 |
An, JX | 1 |
Morena, M | 1 |
Berardi, A | 1 |
Peloso, A | 1 |
Valeri, D | 1 |
Palmery, M | 1 |
Trezza, V | 1 |
Schelling, G | 1 |
Campolongo, P | 1 |
Zhang, S | 1 |
Liang, Z | 2 |
Sun, W | 1 |
Pei, L | 1 |
Wu, L | 1 |
Wang, S | 1 |
Feng, Y | 1 |
Zhao, W | 2 |
Zuo, W | 1 |
Zhong, L | 1 |
Lin, J | 1 |
Luo, F | 1 |
Pavković, Ž | 1 |
Milanović, D | 1 |
Ruždijić, S | 1 |
Kanazir, S | 1 |
Pešić, V | 1 |
Li, X | 2 |
Run, X | 1 |
Wei, Z | 1 |
Zeng, K | 1 |
Huang, F | 1 |
Ke, D | 1 |
Wang, Q | 1 |
Wang, JZ | 1 |
Liu, R | 1 |
Zhang, B | 1 |
Wang, X | 1 |
Zhang, H | 1 |
Zhang, SB | 1 |
Zhang, QQ | 1 |
Liu, M | 1 |
He, XY | 1 |
Zou, Z | 1 |
Sun, HJ | 1 |
You, ZD | 1 |
Shi, XY | 1 |
Lv, F | 2 |
Shen, YW | 1 |
Peng, LH | 1 |
Li, P | 3 |
Luo, J | 3 |
Wei, K | 3 |
Li, W | 1 |
Chen, J | 2 |
Min, S | 5 |
Imashuku, Y | 1 |
Kanemoto, K | 1 |
Senda, M | 1 |
Matsubara, M | 1 |
Yin, J | 1 |
Wang, SL | 1 |
Liu, XB | 1 |
Gomaa, S | 1 |
Yang, B | 1 |
Liang, G | 1 |
Khojasteh, S | 1 |
Wu, Z | 1 |
Yang, W | 1 |
Joseph, D | 1 |
Wei, H | 2 |
Lobo, FA | 1 |
Guimarães, J | 1 |
Schraag, S | 1 |
Engbers, F | 1 |
Tan, H | 1 |
Jiang, W | 1 |
Zuo, Z | 1 |
Liu, G | 1 |
Liu, C | 2 |
Zhang, XN | 1 |
Wang, YL | 3 |
Li, F | 2 |
Chen, X | 3 |
Liu, WF | 1 |
Jin, LH | 1 |
Song, YY | 1 |
Shen, Y | 1 |
Ji, W | 1 |
Zhang, MZ | 1 |
Ren, L | 1 |
Zhang, F | 1 |
Hao, X | 2 |
Qin, P | 1 |
Zhu, X | 1 |
Hao, XC | 1 |
Wang, J | 1 |
Niu, M | 1 |
Bai, S | 1 |
Du, YM | 1 |
Xu, F | 1 |
Liu, D | 1 |
Chen, B | 1 |
Deng, X | 1 |
Wang, B | 1 |
Liu, H | 1 |
Chen, Q | 1 |
Peng, L | 1 |
Meng, H | 1 |
Luo, Q | 1 |
Consoli, A | 1 |
Boulicot, V | 1 |
Cornic, F | 1 |
Fossati, P | 1 |
Barbeau, M | 1 |
Cohen, D | 1 |
Dong, J | 1 |
Liu, YF | 1 |
Wang, H | 1 |
Xu, Z | 1 |
Feng, C | 1 |
Wang, Y | 1 |
Jia, X | 1 |
Wu, A | 1 |
Yue, Y | 1 |
Veselis, RA | 1 |
Reinsel, RA | 1 |
Feshchenko, VA | 1 |
Johnson, R | 1 |
Seidl, S | 1 |
Hausmann, R | 1 |
Neisser, J | 1 |
Janisch, HD | 1 |
Betz, P | 1 |
Baxter, MG | 1 |
Murphy, KL | 1 |
Crosby, G | 1 |
Culley, DJ | 1 |
Nettleingham, P | 1 |
Xiong, W | 1 |
Yang, S | 1 |
Zhou, Q | 1 |
Liang, C | 1 |
Zeng, BX | 1 |
Xu, L | 1 |
Clinical Trials (2)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients: a Multicenter, Randomized, Double-blind, Placebo-controlled Study[NCT05613491] | 438 participants (Anticipated) | Interventional | 2022-11-07 | Recruiting | |||
Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy: A Randomized Controlled Trial[NCT03863925] | Phase 4 | 40 participants (Actual) | Interventional | 2017-08-15 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trials
3 trials available for propofol and Age-Related Memory Disorders
Article | Year |
---|---|
The effects of general anaesthesia on memory in children: a comparison between propofol and sevoflurane.
Topics: Adolescent; Anesthetics, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Female; | 2014 |
Effect of Low Dose of Ketamine on Learning Memory Function in Patients Undergoing Electroconvulsive Therapy-A Randomized, Double-Blind, Controlled Clinical Study.
Topics: Adolescent; Adult; Aged; Anesthesia; Anesthetics, Intravenous; Asian People; Depressive Disorder, Ma | 2017 |
Information loss over time defines the memory defect of propofol: a comparative response with thiopental and dexmedetomidine.
Topics: Dexmedetomidine; Electroencephalography; Female; Humans; Male; Memory Disorders; Pain Measurement; P | 2004 |
Other Studies
33 other studies available for propofol and Age-Related Memory Disorders
Article | Year |
---|---|
Effects of ginsenosides on memory impairment in propofol-anesthetized rats.
Topics: Anesthesia; Animals; Brain-Derived Neurotrophic Factor; Gene Expression Regulation; Ginsenosides; Hi | 2022 |
Dexmedetomidine attenuates postoperative spatial memory impairment after surgery by reducing cytochrome C.
Topics: Animals; Cytochromes c; Dexmedetomidine; Hippocampus; Humans; Male; Memory Disorders; Propofol; Rats | 2023 |
High-dose Propofol Anesthesia Reduces the Occurrence of Postoperative Cognitive Dysfunction via Maintaining Cytoskeleton.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Cytoskeleton; Hippocampus; Male; Maze Learning; Memor | 2019 |
Dexmedetomidine Reverses Postoperative Spatial Memory Deficit by Targeting Surf1 and Cytochrome c.
Topics: Animals; Cytochromes c; Dexmedetomidine; Hippocampus; Male; Memory Disorders; Propofol; Rats; Rats, | 2021 |
Effects of ketamine, dexmedetomidine and propofol anesthesia on emotional memory consolidation in rats: Consequences for the development of post-traumatic stress disorder.
Topics: Animals; Avoidance Learning; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Dr | 2017 |
Repeated propofol anesthesia induced downregulation of hippocampal miR-132 and learning and memory impairment of rats.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Dendritic Spines; Down-Regulation; Female; Hipp | 2017 |
KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy.
Topics: Animals; Biomarkers; Disease Models, Animal; Female; Hippocampus; Kinesins; Learning Disabilities; M | 2018 |
The influence of propofol anesthesia exposure on nonaversive memory retrieval and expression of molecules involved in memory process in the dorsal hippocampus in peripubertal rats.
Topics: Animals; Behavior, Animal; Blotting, Western; Disease Models, Animal; Hippocampus; Hypnotics and Sed | 2018 |
Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.
Topics: Administration, Intranasal; Aging; Anesthesia; Anesthetics, Intravenous; Animals; Brain; Cognitive D | 2019 |
Rescue of cAMP response element-binding protein signaling reversed spatial memory retention impairments induced by subanesthetic dose of propofol.
Topics: Anesthetics, Intravenous; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cues; Cyclic | 2013 |
Effects of propofol on expression of hippocampal neuronal nitric oxide synthase and carboxy-terminal PDZ ligand of neuronal nitric oxide synthase in stressed rats undergoing electroconvulsive shock.
Topics: Adaptor Proteins, Signal Transducing; Animals; Depressive Disorder; Disease Models, Animal; Electros | 2013 |
Relationship between blood levels of propofol and recovery of memory in electroconvulsive therapy.
Topics: Adult; Aged; Anesthetics, Intravenous; Depressive Disorder, Major; Electroconvulsive Therapy; Female | 2014 |
The effects of general anaesthesia on memory in children.
Topics: Anesthetics, General; Female; Humans; Male; Memory Disorders; Methyl Ethers; Postoperative Complicat | 2014 |
Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane.
Topics: Administration, Inhalation; Anesthetics; Animals; Animals, Newborn; Apoptosis; Brain Damage, Chronic | 2014 |
The effect of general anaesthesia on memory in children.
Topics: Anesthetics, General; Female; Humans; Male; Memory Disorders; Methyl Ethers; Postoperative Complicat | 2014 |
The choice of general anesthetics may not affect neuroinflammation and impairment of learning and memory after surgery in elderly rats.
Topics: Anesthetics, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Buprenorphine; Cal | 2015 |
Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats.
Topics: Animals; Depressive Disorder; Dizocilpine Maleate; Electroconvulsive Therapy; Excitatory Amino Acid | 2015 |
Pten Inhibitor-bpV Ameliorates Early Postnatal Propofol Exposure-Induced Memory Deficit and Impairment of Hippocampal LTP.
Topics: Animals; Animals, Newborn; Female; Hippocampus; Long-Term Potentiation; Male; Memory Disorders; Mice | 2015 |
Propofol can Protect Against the Impairment of Learning-memory Induced by Electroconvulsive Shock via Tau Protein Hyperphosphorylation in Depressed Rats.
Topics: Animals; Depression; Dizocilpine Maleate; Electroshock; Glutamic Acid; Learning Disabilities; Male; | 2015 |
Piracetam prevents memory deficit induced by postnatal propofol exposure in mice.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP-Dependent Protein Kinases; D | 2016 |
Post-Exposure Exercise Fails to Ameliorate Memory Impairment Induced by Propofol and Ketamine in Developing Rats.
Topics: Anesthesia; Animals; Body Weight; Conditioning, Psychological; Female; Hippocampus; Immunohistochemi | 2016 |
Propofol ameliorates electroconvulsive shock-induced learning and memory impairment by regulation of synaptic metaplasticity via autophosphorylation of CaMKIIa at Thr 305 in stressed rats.
Topics: Animals; Calcium-Binding Proteins; Carrier Proteins; Depression; Depressive Disorder; Electroconvuls | 2016 |
Propofol Mitigates Learning and Memory Impairment After Electroconvulsive Shock in Depressed Rats by Inhibiting Autophagy in the Hippocampus.
Topics: Animals; Autophagy; Depression; Depressive Disorder; Disease Models, Animal; Electroconvulsive Thera | 2016 |
Effects of long-term infusion of sedatives on the cognitive function and expression level of RAGE in hippocampus of rats.
Topics: Animals; Cognition; Cognition Disorders; Hippocampus; Hypnotics and Sedatives; Learning; Male; Memor | 2016 |
Propofol Prevents Hippocampal Neuronal Loss and Memory Impairment in Cerebral Ischemia Injury Through Promoting PTEN Degradation.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Male; Memory Disorders; Neurons; Neuroprotective A | 2016 |
Persistent neuronal apoptosis and synaptic loss induced by multiple but not single exposure of propofol contribute to long-term cognitive dysfunction in neonatal rats.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; CA1 Region, Hippoc | 2016 |
Moderate clinical improvement with maintenance ECT in a 17-year-old boy with intractable catatonic schizophrenia.
Topics: Adolescent; Anesthetics, Intravenous; Electroconvulsive Therapy; Humans; Male; Memory Disorders; Pro | 2009 |
Propofol protects against impairment of learning-memory and imbalance of hippocampal Glu/GABA induced by electroconvulsive shock in depressed rats.
Topics: Animals; Cognition; Depression; Down-Regulation; Electroconvulsive Therapy; Electroshock; gamma-Amin | 2011 |
Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level.
Topics: Acetylcholine; Aging; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Chemi | 2012 |
Severity and duration of mental deficiency symptoms after intravenous administration of propofol.
Topics: Adult; Aged; Anesthetics, Intravenous; Attention; Automobile Driving; Cognition Disorders; Female; F | 2007 |
Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Behavior, Animal; Denervation; Hippocamp | 2008 |
Anaesthetic drug reaction.
Topics: Dilatation and Curettage; Female; Headache; Humans; Memory Disorders; Propofol; Seizures; Unconsciou | 1993 |
Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; El | 2002 |