Page last updated: 2024-11-03

propofol and Age-Related Memory Disorders

propofol has been researched along with Age-Related Memory Disorders in 36 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
" We found that high-dose propofol anesthesia significantly alleviated spatial memory loss."7.91High-dose Propofol Anesthesia Reduces the Occurrence of Postoperative Cognitive Dysfunction via Maintaining Cytoskeleton. ( An, J; Cao, L; Cope, D; Eastwood, D; Fang, Q; Lin, S; Ma, J; Qian, X; Williams, J; Yuan, Z, 2019)
"Neuroprotective effect of propofol against cerebral ischemia injury was widely investigated."7.83Propofol Prevents Hippocampal Neuronal Loss and Memory Impairment in Cerebral Ischemia Injury Through Promoting PTEN Degradation. ( Chen, X; Du, YM; Liu, D; Wang, YL; Xu, F, 2016)
"3 mg/kg ketamine and then underwent ECT under propofol anesthesia, and a control group, which received isovolumetric placebo (normal saline) and then underwent ECT under propofol anesthesia."5.24Effect of Low Dose of Ketamine on Learning Memory Function in Patients Undergoing Electroconvulsive Therapy-A Randomized, Double-Blind, Controlled Clinical Study. ( Chen, J; Chen, Q; Hao, X; Li, X; Luo, Q; Meng, H; Min, S; Peng, L, 2017)
"To investigate the effects of ginsenosides on the memory impairment in Sprague-Dawley rats (SD rats) after anesthesia through the administration of propofol SPF, SD rats were randomly divided into four groups: control group (Group I), propofol-treated group (Group II), low dose of ginsenosides-treated group (Group III) and high dose of ginsenosides-treated group (Group IV)."4.12Effects of ginsenosides on memory impairment in propofol-anesthetized rats. ( Chen, G; Liu, X; Xie, D; Xu, ZL; Ying, Y; Zhang, J, 2022)
" We found that high-dose propofol anesthesia significantly alleviated spatial memory loss."3.91High-dose Propofol Anesthesia Reduces the Occurrence of Postoperative Cognitive Dysfunction via Maintaining Cytoskeleton. ( An, J; Cao, L; Cope, D; Eastwood, D; Fang, Q; Lin, S; Ma, J; Qian, X; Williams, J; Yuan, Z, 2019)
"BACKGROUND The present study explored the effects of propofol on hippocampal autophagy and synaptophysin in depression-model rats undergoing electroconvulsive shock (ECS)."3.83Propofol Mitigates Learning and Memory Impairment After Electroconvulsive Shock in Depressed Rats by Inhibiting Autophagy in the Hippocampus. ( Hao, XC; Li, P; Luo, J; Lv, F; Min, S; Wei, K, 2016)
"Neuroprotective effect of propofol against cerebral ischemia injury was widely investigated."3.83Propofol Prevents Hippocampal Neuronal Loss and Memory Impairment in Cerebral Ischemia Injury Through Promoting PTEN Degradation. ( Chen, X; Du, YM; Liu, D; Wang, YL; Xu, F, 2016)
"Propofol was added intraperitoneally to the mice from 7th day of insulin/saline treatment, and general anesthesia was induced and maintained for 2 hours/day for 5 consecutive days."1.51Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice. ( Huang, F; Ke, D; Li, X; Liang, Z; Liu, R; Run, X; Wang, JZ; Wang, Q; Wang, X; Wei, Z; Zeng, K; Zhang, B, 2019)
"The isoflurane anaesthesia treatment increased the escape latency contrast to propofol anaesthesia group."1.38Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level. ( Feng, C; Jia, X; Wang, H; Wang, Y; Wu, A; Xu, Z; Yue, Y, 2012)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.78)18.2507
2000's5 (13.89)29.6817
2010's27 (75.00)24.3611
2020's3 (8.33)2.80

Authors

AuthorsStudies
Xu, ZL1
Chen, G1
Liu, X1
Xie, D1
Zhang, J2
Ying, Y1
Sun, L1
Niu, K2
Guo, J2
Tu, J1
Ma, B1
An, J2
Ma, J1
Williams, J1
Eastwood, D1
Lin, S1
Qian, X1
Fang, Q1
Cope, D1
Yuan, Z1
Cao, L1
Qin, JL1
Lu, GF1
Williams, JP1
An, JX1
Morena, M1
Berardi, A1
Peloso, A1
Valeri, D1
Palmery, M1
Trezza, V1
Schelling, G1
Campolongo, P1
Zhang, S1
Liang, Z2
Sun, W1
Pei, L1
Wu, L1
Wang, S1
Feng, Y1
Zhao, W2
Zuo, W1
Zhong, L1
Lin, J1
Luo, F1
Pavković, Ž1
Milanović, D1
Ruždijić, S1
Kanazir, S1
Pešić, V1
Li, X2
Run, X1
Wei, Z1
Zeng, K1
Huang, F1
Ke, D1
Wang, Q1
Wang, JZ1
Liu, R1
Zhang, B1
Wang, X1
Zhang, H1
Zhang, SB1
Zhang, QQ1
Liu, M1
He, XY1
Zou, Z1
Sun, HJ1
You, ZD1
Shi, XY1
Lv, F2
Shen, YW1
Peng, LH1
Li, P3
Luo, J3
Wei, K3
Li, W1
Chen, J2
Min, S5
Imashuku, Y1
Kanemoto, K1
Senda, M1
Matsubara, M1
Yin, J1
Wang, SL1
Liu, XB1
Gomaa, S1
Yang, B1
Liang, G1
Khojasteh, S1
Wu, Z1
Yang, W1
Joseph, D1
Wei, H2
Lobo, FA1
Guimarães, J1
Schraag, S1
Engbers, F1
Tan, H1
Jiang, W1
Zuo, Z1
Liu, G1
Liu, C2
Zhang, XN1
Wang, YL3
Li, F2
Chen, X3
Liu, WF1
Jin, LH1
Song, YY1
Shen, Y1
Ji, W1
Zhang, MZ1
Ren, L1
Zhang, F1
Hao, X2
Qin, P1
Zhu, X1
Hao, XC1
Wang, J1
Niu, M1
Bai, S1
Du, YM1
Xu, F1
Liu, D1
Chen, B1
Deng, X1
Wang, B1
Liu, H1
Chen, Q1
Peng, L1
Meng, H1
Luo, Q1
Consoli, A1
Boulicot, V1
Cornic, F1
Fossati, P1
Barbeau, M1
Cohen, D1
Dong, J1
Liu, YF1
Wang, H1
Xu, Z1
Feng, C1
Wang, Y1
Jia, X1
Wu, A1
Yue, Y1
Veselis, RA1
Reinsel, RA1
Feshchenko, VA1
Johnson, R1
Seidl, S1
Hausmann, R1
Neisser, J1
Janisch, HD1
Betz, P1
Baxter, MG1
Murphy, KL1
Crosby, G1
Culley, DJ1
Nettleingham, P1
Xiong, W1
Yang, S1
Zhou, Q1
Liang, C1
Zeng, BX1
Xu, L1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients: a Multicenter, Randomized, Double-blind, Placebo-controlled Study[NCT05613491]438 participants (Anticipated)Interventional2022-11-07Recruiting
Comparison of Propofol Target-Controlled Infusion Anesthesia and Bolus Injection in Electroconvulsive Therapy: A Randomized Controlled Trial[NCT03863925]Phase 440 participants (Actual)Interventional2017-08-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for propofol and Age-Related Memory Disorders

ArticleYear
The effects of general anaesthesia on memory in children: a comparison between propofol and sevoflurane.
    Anaesthesia, 2014, Volume: 69, Issue:2

    Topics: Adolescent; Anesthetics, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Female;

2014
Effect of Low Dose of Ketamine on Learning Memory Function in Patients Undergoing Electroconvulsive Therapy-A Randomized, Double-Blind, Controlled Clinical Study.
    The journal of ECT, 2017, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthesia; Anesthetics, Intravenous; Asian People; Depressive Disorder, Ma

2017
Information loss over time defines the memory defect of propofol: a comparative response with thiopental and dexmedetomidine.
    Anesthesiology, 2004, Volume: 101, Issue:4

    Topics: Dexmedetomidine; Electroencephalography; Female; Humans; Male; Memory Disorders; Pain Measurement; P

2004

Other Studies

33 other studies available for propofol and Age-Related Memory Disorders

ArticleYear
Effects of ginsenosides on memory impairment in propofol-anesthetized rats.
    Bioengineered, 2022, Volume: 13, Issue:1

    Topics: Anesthesia; Animals; Brain-Derived Neurotrophic Factor; Gene Expression Regulation; Ginsenosides; Hi

2022
Dexmedetomidine attenuates postoperative spatial memory impairment after surgery by reducing cytochrome C.
    BMC anesthesiology, 2023, 03-20, Volume: 23, Issue:1

    Topics: Animals; Cytochromes c; Dexmedetomidine; Hippocampus; Humans; Male; Memory Disorders; Propofol; Rats

2023
High-dose Propofol Anesthesia Reduces the Occurrence of Postoperative Cognitive Dysfunction via Maintaining Cytoskeleton.
    Neuroscience, 2019, 11-21, Volume: 421

    Topics: Anesthesia; Anesthetics, Intravenous; Animals; Cytoskeleton; Hippocampus; Male; Maze Learning; Memor

2019
Dexmedetomidine Reverses Postoperative Spatial Memory Deficit by Targeting Surf1 and Cytochrome c.
    Neuroscience, 2021, 07-01, Volume: 466

    Topics: Animals; Cytochromes c; Dexmedetomidine; Hippocampus; Male; Memory Disorders; Propofol; Rats; Rats,

2021
Effects of ketamine, dexmedetomidine and propofol anesthesia on emotional memory consolidation in rats: Consequences for the development of post-traumatic stress disorder.
    Behavioural brain research, 2017, 06-30, Volume: 329

    Topics: Animals; Avoidance Learning; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Dr

2017
Repeated propofol anesthesia induced downregulation of hippocampal miR-132 and learning and memory impairment of rats.
    Brain research, 2017, Sep-01, Volume: 1670

    Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Dendritic Spines; Down-Regulation; Female; Hipp

2017
KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy.
    Molecular medicine reports, 2018, Volume: 17, Issue:4

    Topics: Animals; Biomarkers; Disease Models, Animal; Female; Hippocampus; Kinesins; Learning Disabilities; M

2018
The influence of propofol anesthesia exposure on nonaversive memory retrieval and expression of molecules involved in memory process in the dorsal hippocampus in peripubertal rats.
    Paediatric anaesthesia, 2018, Volume: 28, Issue:6

    Topics: Animals; Behavior, Animal; Blotting, Western; Disease Models, Animal; Hippocampus; Hypnotics and Sed

2018
Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.
    Current Alzheimer research, 2019, Volume: 16, Issue:1

    Topics: Administration, Intranasal; Aging; Anesthesia; Anesthetics, Intravenous; Animals; Brain; Cognitive D

2019
Rescue of cAMP response element-binding protein signaling reversed spatial memory retention impairments induced by subanesthetic dose of propofol.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:7

    Topics: Anesthetics, Intravenous; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cues; Cyclic

2013
Effects of propofol on expression of hippocampal neuronal nitric oxide synthase and carboxy-terminal PDZ ligand of neuronal nitric oxide synthase in stressed rats undergoing electroconvulsive shock.
    The journal of ECT, 2013, Volume: 29, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Animals; Depressive Disorder; Disease Models, Animal; Electros

2013
Relationship between blood levels of propofol and recovery of memory in electroconvulsive therapy.
    Psychiatry and clinical neurosciences, 2014, Volume: 68, Issue:4

    Topics: Adult; Aged; Anesthetics, Intravenous; Depressive Disorder, Major; Electroconvulsive Therapy; Female

2014
The effects of general anaesthesia on memory in children.
    Anaesthesia, 2014, Volume: 69, Issue:6

    Topics: Anesthetics, General; Female; Humans; Male; Memory Disorders; Methyl Ethers; Postoperative Complicat

2014
Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Administration, Inhalation; Anesthetics; Animals; Animals, Newborn; Apoptosis; Brain Damage, Chronic

2014
The effect of general anaesthesia on memory in children.
    Anaesthesia, 2014, Volume: 69, Issue:9

    Topics: Anesthetics, General; Female; Humans; Male; Memory Disorders; Methyl Ethers; Postoperative Complicat

2014
The choice of general anesthetics may not affect neuroinflammation and impairment of learning and memory after surgery in elderly rats.
    Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2015, Volume: 10, Issue:1

    Topics: Anesthetics, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Buprenorphine; Cal

2015
Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats.
    Molecular medicine reports, 2015, Volume: 12, Issue:3

    Topics: Animals; Depressive Disorder; Dizocilpine Maleate; Electroconvulsive Therapy; Excitatory Amino Acid

2015
Pten Inhibitor-bpV Ameliorates Early Postnatal Propofol Exposure-Induced Memory Deficit and Impairment of Hippocampal LTP.
    Neurochemical research, 2015, Volume: 40, Issue:8

    Topics: Animals; Animals, Newborn; Female; Hippocampus; Long-Term Potentiation; Male; Memory Disorders; Mice

2015
Propofol can Protect Against the Impairment of Learning-memory Induced by Electroconvulsive Shock via Tau Protein Hyperphosphorylation in Depressed Rats.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2015, Volume: 30, Issue:2

    Topics: Animals; Depression; Dizocilpine Maleate; Electroshock; Glutamic Acid; Learning Disabilities; Male;

2015
Piracetam prevents memory deficit induced by postnatal propofol exposure in mice.
    European journal of pharmacology, 2016, May-15, Volume: 779

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP-Dependent Protein Kinases; D

2016
Post-Exposure Exercise Fails to Ameliorate Memory Impairment Induced by Propofol and Ketamine in Developing Rats.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, Mar-30, Volume: 22

    Topics: Anesthesia; Animals; Body Weight; Conditioning, Psychological; Female; Hippocampus; Immunohistochemi

2016
Propofol ameliorates electroconvulsive shock-induced learning and memory impairment by regulation of synaptic metaplasticity via autophosphorylation of CaMKIIa at Thr 305 in stressed rats.
    Psychiatry research, 2016, 06-30, Volume: 240

    Topics: Animals; Calcium-Binding Proteins; Carrier Proteins; Depression; Depressive Disorder; Electroconvuls

2016
Propofol Mitigates Learning and Memory Impairment After Electroconvulsive Shock in Depressed Rats by Inhibiting Autophagy in the Hippocampus.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, May-20, Volume: 22

    Topics: Animals; Autophagy; Depression; Depressive Disorder; Disease Models, Animal; Electroconvulsive Thera

2016
Effects of long-term infusion of sedatives on the cognitive function and expression level of RAGE in hippocampus of rats.
    Journal of anesthesia, 2016, Volume: 30, Issue:4

    Topics: Animals; Cognition; Cognition Disorders; Hippocampus; Hypnotics and Sedatives; Learning; Male; Memor

2016
Propofol Prevents Hippocampal Neuronal Loss and Memory Impairment in Cerebral Ischemia Injury Through Promoting PTEN Degradation.
    Journal of molecular neuroscience : MN, 2016, Volume: 60, Issue:1

    Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Male; Memory Disorders; Neurons; Neuroprotective A

2016
Persistent neuronal apoptosis and synaptic loss induced by multiple but not single exposure of propofol contribute to long-term cognitive dysfunction in neonatal rats.
    The Journal of toxicological sciences, 2016, Volume: 41, Issue:5

    Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; CA1 Region, Hippoc

2016
Moderate clinical improvement with maintenance ECT in a 17-year-old boy with intractable catatonic schizophrenia.
    European child & adolescent psychiatry, 2009, Volume: 18, Issue:4

    Topics: Adolescent; Anesthetics, Intravenous; Electroconvulsive Therapy; Humans; Male; Memory Disorders; Pro

2009
Propofol protects against impairment of learning-memory and imbalance of hippocampal Glu/GABA induced by electroconvulsive shock in depressed rats.
    Journal of anesthesia, 2011, Volume: 25, Issue:5

    Topics: Animals; Cognition; Depression; Down-Regulation; Electroconvulsive Therapy; Electroshock; gamma-Amin

2011
Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level.
    Annales francaises d'anesthesie et de reanimation, 2012, Volume: 31, Issue:3

    Topics: Acetylcholine; Aging; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Chemi

2012
Severity and duration of mental deficiency symptoms after intravenous administration of propofol.
    International journal of legal medicine, 2007, Volume: 121, Issue:4

    Topics: Adult; Aged; Anesthetics, Intravenous; Attention; Automobile Driving; Cognition Disorders; Female; F

2007
Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia.
    Hippocampus, 2008, Volume: 18, Issue:3

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Behavior, Animal; Denervation; Hippocamp

2008
Anaesthetic drug reaction.
    The New Zealand medical journal, 1993, Nov-24, Volume: 106, Issue:968

    Topics: Dilatation and Curettage; Female; Headache; Humans; Memory Disorders; Propofol; Seizures; Unconsciou

1993
Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats.
    Neuroscience letters, 2002, May-24, Volume: 324, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; El

2002
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