primaquine has been researched along with Sensitivity and Specificity in 17 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A rapid single-step screening method for detection of glucose-6-phosphate dehydrogenase (G6 PD) deficiency was evaluated on Halmahera Island, Maluku Province, Indonesia, and in Shan and Mon States, Myanmar, in combination with a rapid diagnosis of malaria by an acridine orange staining method." | 5.09 | Field trials of a rapid test for G6PD deficiency in combination with a rapid diagnosis of malaria. ( Basuki, S; Dachlan, YP; Horie, T; Htay, HH; Ishii, A; Iwai, K; Kawamoto, F; Kojima, S; Lin, K; Marwoto, H; Matsuoka, H; Tantular, IS; Wongsrichanalai, C, 1999) |
| "To reduce the risk of drug-induced haemolysis, all patients should be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) prior to prescribing primaquine (PQ)-based radical cure for the treatment of vivax malaria." | 5.01 | Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis. ( Bancone, G; Douglas, NM; Espino, F; Henriques, G; Karahalios, A; Ley, B; Menard, D; Oo, NN; Parikh, S; Pfeffer, DA; Price, RN; Rahmat, H; von Fricken, ME; von Seidlein, L; Winasti Satyagraha, A, 2019) |
| " Most HCPs were unaware of G6PD deficiency and primaquine-related adverse effects." | 1.62 | Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study). ( Arcanjo, AR; Baia-da-Silva, DC; Bancone, G; Barbosa, LRA; Bassat, Q; Batista, TSB; Brito, MAM; Brito-Sousa, JD; Domingo, GJ; Figueiredo, EFG; Lacerda, MVG; Marques, LLG; Melo, GC; Melo, MM; Mendes, MO; Monteiro, WM; Murta, F; Nakagawa, TH; Recht, J; Rodovalho, S; Sampaio, VS; Santos, APC; Santos, TC; Silva, EL; Silva-Neto, AV; Siqueira, AM; Souza, BKA; Vitor-Silva, S, 2021) |
| "The prevalence of G6PD deficiency in the Bamar, Karen and in the whole sample set was 6." | 1.43 | Validation of G6PD Point-of-Care Tests among Healthy Volunteers in Yangon, Myanmar. ( Bancone, G; Bansil, P; Chowwiwat, N; Domingo, GJ; Htun, MM; Htut, Y; Maw, LZ; Nosten, F; Oo, NN; Thant, KZ, 2016) |
| " Total runtime for the method was 5min, which was suitable to produce high-throughput results for pharmacokinetic evaluation." | 1.36 | Development and validation of a sensitive and selective UHPLC-MS/MS method for quantitation of an investigational anti-malarial compound, 2-tert-butylprimaquine (NP-96) in rat plasma, and its application in a preclinical pharmacokinetic study. ( Jain, M; Jain, R; Mayatra, SJ; Prasad, B; Singh, S, 2010) |
| " The method was applied to determine the pharmacokinetic parameters of AM in 5 rabbits receiving a single bolus intravenous and peroral dose in a crossover study." | 1.30 | A rapid and sensitive high performance liquid chromatographic assay of the new antimalarial compound 80/53 in serum with a novel sample clean-up method and its pharmacokinetics in rabbits. ( Gupta, RC; Paliwal, JK, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Kaagaard, MD | 1 |
| Matos, LO | 1 |
| Holm, AE | 1 |
| Gomes, LC | 1 |
| Wegener, A | 1 |
| Lima, KO | 1 |
| Vieira, IVM | 1 |
| de Souza, RM | 1 |
| Marinho, CRF | 1 |
| Hviid, L | 1 |
| Vestergaard, LS | 1 |
| Dominguez, H | 1 |
| Biering-Sørensen, T | 1 |
| Silvestre, OM | 1 |
| Brainin, P | 1 |
| Ley, B | 1 |
| Winasti Satyagraha, A | 1 |
| Rahmat, H | 1 |
| von Fricken, ME | 1 |
| Douglas, NM | 1 |
| Pfeffer, DA | 1 |
| Espino, F | 1 |
| von Seidlein, L | 1 |
| Henriques, G | 1 |
| Oo, NN | 2 |
| Menard, D | 1 |
| Parikh, S | 1 |
| Bancone, G | 4 |
| Karahalios, A | 1 |
| Price, RN | 1 |
| Brito-Sousa, JD | 1 |
| Murta, F | 1 |
| Vitor-Silva, S | 1 |
| Sampaio, VS | 1 |
| Mendes, MO | 1 |
| Brito, MAM | 1 |
| Batista, TSB | 1 |
| Santos, APC | 1 |
| Marques, LLG | 1 |
| Barbosa, LRA | 1 |
| Melo, MM | 1 |
| Baia-da-Silva, DC | 1 |
| Silva-Neto, AV | 1 |
| Santos, TC | 1 |
| Souza, BKA | 1 |
| Figueiredo, EFG | 1 |
| Silva, EL | 1 |
| Rodovalho, S | 1 |
| Nakagawa, TH | 1 |
| Arcanjo, AR | 1 |
| Siqueira, AM | 1 |
| Melo, GC | 1 |
| Recht, J | 1 |
| Domingo, GJ | 3 |
| Bassat, Q | 1 |
| Monteiro, WM | 1 |
| Lacerda, MVG | 1 |
| Reuken, PA | 1 |
| Baier, M | 1 |
| Hagel, S | 1 |
| Eisermann, P | 1 |
| Stallmach, A | 1 |
| Rödel, J | 1 |
| Rochford, R | 1 |
| Ohrt, C | 1 |
| Baresel, PC | 1 |
| Campo, B | 1 |
| Sampath, A | 1 |
| Magill, AJ | 1 |
| Tekwani, BL | 1 |
| Walker, LA | 1 |
| Chu, CS | 1 |
| Chowwiwat, N | 2 |
| Somsakchaicharoen, R | 1 |
| Wilaisrisak, P | 1 |
| Charunwatthana, P | 1 |
| Bansil, P | 2 |
| McGray, S | 1 |
| Nosten, FH | 1 |
| Maw, LZ | 1 |
| Htun, MM | 1 |
| Thant, KZ | 1 |
| Htut, Y | 1 |
| Nosten, F | 1 |
| Elbashir, AA | 2 |
| Saad, B | 2 |
| Ali, AS | 2 |
| Saleh, MI | 2 |
| Aboul-Enein, HY | 2 |
| Mayatra, SJ | 1 |
| Prasad, B | 1 |
| Jain, M | 1 |
| Jain, R | 1 |
| Singh, S | 1 |
| Page-Sharp, M | 1 |
| Ilett, KF | 1 |
| Betuela, I | 1 |
| Davis, TM | 1 |
| Batty, KT | 1 |
| Nitin, M | 1 |
| Rajanikanth, M | 1 |
| Lal, J | 1 |
| Madhusudanan, KP | 1 |
| Gupta, RC | 2 |
| Singh, N | 1 |
| Mishra, AK | 1 |
| Shukla, MM | 1 |
| Chand, SK | 1 |
| Bharti, PK | 1 |
| Dongre, VG | 1 |
| Karmuse, PP | 1 |
| Rao, PP | 1 |
| Kumar, A | 1 |
| Paliwal, JK | 1 |
| Tantular, IS | 1 |
| Iwai, K | 1 |
| Lin, K | 1 |
| Basuki, S | 1 |
| Horie, T | 1 |
| Htay, HH | 1 |
| Matsuoka, H | 1 |
| Marwoto, H | 1 |
| Wongsrichanalai, C | 1 |
| Dachlan, YP | 1 |
| Kojima, S | 1 |
| Ishii, A | 1 |
| Kawamoto, F | 1 |
| Carrasquilla, G | 1 |
| Banguero, M | 1 |
| Sanchez, P | 1 |
| Carvajal, F | 1 |
| Barker, RH | 1 |
| Gervais, GW | 1 |
| Algarin, E | 1 |
| Serrano, AE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Malaria Heart Disease Study: A Novel Pathway to Subclinical Heart Disease[NCT04445103] | 597 participants (Actual) | Observational | 2020-06-21 | Terminated (stopped due to Due to the COVID-19 pandemic it was not possible to complete the study inclusion as originally anticipated.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for primaquine and Sensitivity and Specificity
| Article | Year |
|---|---|
Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis.
Topics: Diagnostic Tests, Routine; Endemic Diseases; Female; Glucosephosphate Dehydrogenase; Glucosephosphat | 2019 |
1 trial available for primaquine and Sensitivity and Specificity
| Article | Year |
|---|---|
Field trials of a rapid test for G6PD deficiency in combination with a rapid diagnosis of malaria.
Topics: Acridine Orange; Antimalarials; Case-Control Studies; Contraindications; Female; Fluorescent Dyes; G | 1999 |
15 other studies available for primaquine and Sensitivity and Specificity
| Article | Year |
|---|---|
Frequency of Electrocardiographic Alterations and Pericardial Effusion in Patients With Uncomplicated Malaria.
Topics: Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Brazil; Case-Control Studies; Chlor | 2022 |
Real-life implementation of a G6PD deficiency screening qualitative test into routine vivax malaria diagnostic units in the Brazilian Amazon (SAFEPRIM study).
Topics: Antimalarials; Brazil; Glucosephosphate Dehydrogenase Deficiency; Health Personnel; Hemolysis; Human | 2021 |
Diagnosis of malaria in a traveler 9 months after returning from West Africa by
Topics: Africa, Western; Antimalarials; Atovaquone; Drug Combinations; Germany; Humans; Malaria; Male; Middl | 2019 |
Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity.
Topics: Aminoquinolines; Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Combined Modality Therapy; | 2013 |
Suitability of capillary blood for quantitative assessment of G6PD activity and performances of G6PD point-of-care tests.
Topics: Aminoquinolines; Antimalarials; Capillaries; Clinical Enzyme Tests; Erythrocytes; Female; Glucosepho | 2015 |
Validation of G6PD Point-of-Care Tests among Healthy Volunteers in Yangon, Myanmar.
Topics: Adult; Antimalarials; Equipment Design; Female; Fluorescence; Glucosephosphate Dehydrogenase; Glucos | 2016 |
Enantioselective analysis of primaquine and its impurity quinocide by capillary electrophoresis.
Topics: Aminoquinolines; Antimalarials; Cyclodextrins; Drug Contamination; Electrophoresis, Capillary; Hydro | 2009 |
Determination of quinocide as impurity in primaquine tablets by capillary zone electrophoresis.
Topics: Aminoquinolines; Antimalarials; beta-Cyclodextrins; Crown Ethers; Drug Contamination; Electrophoresi | 2009 |
Development and validation of a sensitive and selective UHPLC-MS/MS method for quantitation of an investigational anti-malarial compound, 2-tert-butylprimaquine (NP-96) in rat plasma, and its application in a preclinical pharmacokinetic study.
Topics: Animals; Antimalarials; Calibration; Chromatography, High Pressure Liquid; Dose-Response Relationshi | 2010 |
Simultaneous determination of primaquine and carboxyprimaquine in plasma using solid phase extraction and LC-MS assay.
Topics: Child; Chromatography, Liquid; Female; Humans; Male; Primaquine; Reproducibility of Results; Sensiti | 2012 |
Liquid chromatography-tandem mass spectrometric assay with a novel method of quantitation for the simultaneous determination of bulaquine and its metabolite, primaquine, in monkey plasma.
Topics: Animals; Antimalarials; Haplorhini; Primaquine; Reproducibility of Results; Sensitivity and Specific | 2003 |
Diagnostic and prognostic utility of an inexpensive rapid on site malaria diagnostic test (ParaHIT f) among ethnic tribal population in areas of high, low and no transmission in central India.
Topics: Adult; Antimalarials; Child; Chloroquine; Ethnicity; Female; Humans; India; Infant; Malaria, Falcipa | 2005 |
Development and validation of UPLC method for determination of primaquine phosphate and its impurities.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Primaquine; Reproducibility of Results; Sensiti | 2008 |
A rapid and sensitive high performance liquid chromatographic assay of the new antimalarial compound 80/53 in serum with a novel sample clean-up method and its pharmacokinetics in rabbits.
Topics: Animals; Antimalarials; Chromatography, High Pressure Liquid; Haplorhini; Humans; Primaquine; Rabbit | 1998 |
Epidemiologic tools for malaria surveillance in an urban setting of low endemicity along the Colombian Pacific coast.
Topics: Animals; Antimalarials; Blood; Blotting, Southern; Chloroquine; Colombia; Cross-Sectional Studies; D | 2000 |