prazosin and Hypoxia
prazosin has been researched along with Hypoxia in 30 studies
Prazosin: A selective adrenergic alpha-1 antagonist used in the treatment of HEART FAILURE; HYPERTENSION; PHEOCHROMOCYTOMA; RAYNAUD DISEASE; PROSTATIC HYPERTROPHY; and URINARY RETENTION.
prazosin : A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immediate induction of combined hypoxemia and hypercapnic acidosis after control measurements during intrarenal vehicle infusion resulted in a decrease in effective renal plasma flow and glomerular filtration rate, increase in renal vascular resistance, and decrease in filtered sodium load in the first 20 minutes of the blood gas derangement." | 5.28 | Role of intrarenal angiotensin II and alpha-adrenoceptors in renal vasoconstriction with acute hypoxemia and hypercapnic acidosis in conscious dogs. ( Brashers, VL; Carey, RM; Dacus, WS; Peach, MJ; Rose, CE; Vance, JE, 1991) |
| " We show that repeated obstructive apneas disrupt vagal feedback and trigger LTF of hypoglossal motoneuron activity and genioglossus muscle tone." | 3.76 | Identification of a novel form of noradrenergic-dependent respiratory motor plasticity triggered by vagal feedback. ( Duffin, J; Peever, J; Tadjalli, A, 2010) |
| " In sparse cultures (average cell density 259 cells/mm(2)), both hypoxic preconditioning (n=5) and phenylephrine pretreatment (n=8) produced significant protection of cardiac myocytes from cell death during a prolonged period of severe hypoxia (<0." | 3.70 | Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxide dismutase. ( Epstein, CJ; Gray, MO; Honbo, N; Karliner, JS; Lau, YF; Xian, M, 2000) |
| "The present study was undertaken to assess the effect of prazosin, a selective postsynaptic alpha 1-adrenergic receptor blocking agent, on normoxic and hypoxic mice, in order to evaluate experimentally its use in the treatment of the excessive erythrocytosis that characterizes chronic mountain sickness." | 3.69 | Inhibitory effect of an alpha 1-adrenergic antagonist on erythropoiesis in normoxic or hypoxic mice. ( Alippi, RM; Barcelò, AC; Bozzini, CE; Huicho, L; Izaguirre, V; León-Velarde, F; Monge, C; Vargas, M, 1994) |
| " To test the hypothesis that hypoxia-induced developmental and vessel specific cerebral artery contractility changes are mediated, in part, by changes in alpha1-adrenergic receptor (alpha1-AR) density and/or NE-induced inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] responses, we performed the following study." | 3.69 | High altitude-induced changes in alpha1-adrenergic receptors and Ins(1,4,5)P3 responses in cerebral arteries. ( Longo, LD; Ueno, N; Zhang, L; Zhao, Y, 1997) |
| " It was found that the pulmonary vessels were more sensitive to alveolar hypoxia in hypothermic dogs, and that hypoxic pulmonary vasoconstriction (HPV) was enhanced, which could be inhibited by alpha 1-adrenoceptor blocker prazosin." | 3.68 | Alteration in hypoxic pulmonary vasoconstriction during hypothermia in dogs. ( Fan, M; Wang, DX; Zhu, ZH, 1992) |
| " Data showed that an increment of pulmonary vascular resistance (PVR) induced by alveolar hypoxia was partially prevented by prazosin (alpha 1-receptor blocker) and prazosin combined with propranolol (beta-receptor blocker), but not significantly affected by propranolol or adrenalectomy." | 3.68 | Role of sympathetic nerve and adrenal gland in the potentiation of hypoxic pulmonary vasoconstriction during cigarette smoking. ( Wang, DX; Wang, WH, 1992) |
| " In contrast with traditional dose-response studies, it was possible to quantify separately the underlying changes in α1 AR binding and signal transduction." | 1.40 | Effect of disease states on α1 -adrenoceptor binding and signal transduction parameters in isolated perfused heart: quantification by pharmacokinetic-pharmacodynamic modelling. ( Arendt, P; Hassna, R; Weiss, M, 2014) |
| "Hearts from animal models of type 2 diabetes present with abnormal contractility patterns." | 1.32 | A role for the alpha1-adrenergic signalling pathway in the response of papillary muscles from type 2 diabetic hearts to anoxia-reoxygenation. ( Huisamen, B; Lochner, A; Upton, J, 2004) |
| " The norepinephrine dose-response curves were shifted to the right and the concentrations at which 50% of the maximal response was attained were increased 3." | 1.29 | Effects of long-term high-altitude hypoxemia on alpha 1-adrenergic receptors in the ovine uterine artery. ( Gilbert, RD; Hu, XQ; Longo, LD; Zhang, L, 1996) |
| "Prazosin treatment during normoxemia caused a fall in blood pressure and resulted in greater blood flows of left ventricular origin to the carcass, myocardium and lung." | 1.28 | Effect of prazosin on hypoxemia-induced blood flow redistribution in the newborn piglet. ( Green, RS; Holzman, IR; Lasker, MR; McDonnell, FE, 1992) |
| "Immediate induction of combined hypoxemia and hypercapnic acidosis after control measurements during intrarenal vehicle infusion resulted in a decrease in effective renal plasma flow and glomerular filtration rate, increase in renal vascular resistance, and decrease in filtered sodium load in the first 20 minutes of the blood gas derangement." | 1.28 | Role of intrarenal angiotensin II and alpha-adrenoceptors in renal vasoconstriction with acute hypoxemia and hypercapnic acidosis in conscious dogs. ( Brashers, VL; Carey, RM; Dacus, WS; Peach, MJ; Rose, CE; Vance, JE, 1991) |
| "When monensin was applied simultaneously with ouabain, there was a rapid increase in cellular Na+ and loss of cellular K+." | 1.27 | Action of the Na+ ionophore monensin on vascular smooth muscle of guinea-pig aorta. ( Chihara, S; Kishimoto, T; Ozaki, H; Umeno, H; Urakawa, N, 1984) |
Research
Studies (30)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 12 (40.00) | 18.2507 |
| 2000's | 7 (23.33) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Weiss, M | 1 |
| Arendt, P | 1 |
| Hassna, R | 1 |
| Gao, L | 1 |
| Chen, L | 1 |
| Lu, ZZ | 1 |
| Gao, H | 1 |
| Wu, L | 1 |
| Chen, YX | 1 |
| Zhang, CM | 1 |
| Jiang, YK | 1 |
| Jing, Q | 1 |
| Zhang, YY | 1 |
| Yang, HT | 1 |
| Tymko, MM | 1 |
| Tremblay, JC | 1 |
| Hansen, AB | 1 |
| Howe, CA | 1 |
| Willie, CK | 1 |
| Stembridge, M | 1 |
| Green, DJ | 1 |
| Hoiland, RL | 1 |
| Subedi, P | 1 |
| Anholm, JD | 1 |
| Ainslie, PN | 1 |
| Stickland, MK | 1 |
| Smith, CA | 1 |
| Soriano, BJ | 1 |
| Dempsey, JA | 1 |
| Tadjalli, A | 1 |
| Duffin, J | 1 |
| Peever, J | 1 |
| Stettner, GM | 1 |
| Fenik, VB | 1 |
| Kubin, L | 1 |
| Huisamen, B | 1 |
| Upton, J | 1 |
| Lochner, A | 1 |
| Sandblom, E | 2 |
| Axelsson, M | 2 |
| Tual, L | 1 |
| Morel, OE | 1 |
| Favret, F | 1 |
| Fouillit, M | 1 |
| Guernier, C | 1 |
| Buvry, A | 1 |
| Germain, L | 1 |
| Dhonneur, G | 1 |
| Bernaudin, JF | 1 |
| Richalet, JP | 1 |
| Wagerle, LC | 1 |
| Heffernan, TM | 1 |
| Sacks, LM | 1 |
| Delivoria-Papadopoulos, M | 1 |
| Ozaki, H | 1 |
| Kishimoto, T | 1 |
| Chihara, S | 1 |
| Umeno, H | 1 |
| Urakawa, N | 1 |
| Izaguirre, V | 1 |
| Vargas, M | 1 |
| León-Velarde, F | 1 |
| Huicho, L | 1 |
| Monge, C | 1 |
| Barcelò, AC | 1 |
| Alippi, RM | 1 |
| Bozzini, CE | 1 |
| Sundin, LI | 1 |
| Hurst, JA | 1 |
| Houlston, RS | 1 |
| Roberts, A | 1 |
| Gould, SJ | 1 |
| Tingey, WG | 1 |
| Hu, XQ | 1 |
| Longo, LD | 3 |
| Gilbert, RD | 1 |
| Zhang, L | 3 |
| Fletcher, EC | 1 |
| Bao, G | 1 |
| Ueno, N | 1 |
| Zhao, Y | 1 |
| Hu, X | 1 |
| Kaloyianni, M | 1 |
| Papaefthimiou, I | 1 |
| Simeonidou, V | 1 |
| Karliner, JS | 1 |
| Honbo, N | 1 |
| Epstein, CJ | 1 |
| Xian, M | 1 |
| Lau, YF | 1 |
| Gray, MO | 1 |
| Fan, M | 1 |
| Wang, DX | 2 |
| Zhu, ZH | 1 |
| Green, RS | 1 |
| Lasker, MR | 1 |
| McDonnell, FE | 1 |
| Holzman, IR | 1 |
| Wang, WH | 1 |
| Rose, CE | 2 |
| Vance, JE | 1 |
| Dacus, WS | 1 |
| Brashers, VL | 2 |
| Peach, MJ | 1 |
| Carey, RM | 2 |
| Downey, HF | 1 |
| Grice, DP | 1 |
| Jones, CE | 1 |
| Zierhut, W | 1 |
| Zimmer, HG | 1 |
| Dougherty, MJ | 1 |
| Godine, RL | 1 |
| Latham, LB | 1 |
| Rose, KY | 1 |
| Heathers, GP | 1 |
| Yamada, KA | 1 |
| Kanter, EM | 1 |
| Corr, PB | 1 |
| Delpierre, S | 1 |
| Peyrot, J | 1 |
| Guillot, C | 1 |
| Grimaud, C | 1 |
Trials
1 trial available for prazosin and Hypoxia
| Article | Year |
|---|---|
The effect of α
Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Altitude; Brachial Artery; Double-Blind Method; Exer | 2017 |
Other Studies
29 other studies available for prazosin and Hypoxia
| Article | Year |
|---|---|
Effect of disease states on α1 -adrenoceptor binding and signal transduction parameters in isolated perfused heart: quantification by pharmacokinetic-pharmacodynamic modelling.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Endotoxemia; | 2014 |
Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved postischemic myocardial performance via inhibiting MMP-2 activation.
Topics: Actinin; Adrenergic alpha-1 Receptor Antagonists; Animals; Doxycycline; Hypoxia; Male; Matrix Metall | 2014 |
Sympathetic restraint of muscle blood flow during hypoxic exercise.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiac Output; Dogs; Female; Hypoxia; Models | 2009 |
Identification of a novel form of noradrenergic-dependent respiratory motor plasticity triggered by vagal feedback.
Topics: Adrenergic alpha-1 Receptor Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; A | 2010 |
Effect of chronic intermittent hypoxia on noradrenergic activation of hypoglossal motoneurons.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic Neurons; Animals; Disease Models, Animal; Hypogl | 2012 |
A role for the alpha1-adrenergic signalling pathway in the response of papillary muscles from type 2 diabetic hearts to anoxia-reoxygenation.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Biomarkers; Blood Glucose; Diabete | 2004 |
Effects of hypoxia on the venous circulation in rainbow trout (Oncorhynchus mykiss).
Topics: Adrenergic alpha-Antagonists; Animals; Bradycardia; Cardiac Output; Central Venous Pressure; Female; | 2005 |
Carvedilol inhibits right ventricular hypertrophy induced by chronic hypobaric hypoxia.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Carbazoles; Carvedilol; Chronic Disease; Hypertrop | 2006 |
Adrenergic control of venous capacitance during moderate hypoxia in the rainbow trout (Oncorhynchus mykiss): role of neural and circulating catecholamines.
Topics: Adrenergic alpha-Antagonists; Animals; Bretylium Compounds; Catecholamines; Hypoxia; Oncorhynchus my | 2006 |
Sympathetic effect on cerebral blood flow regulation in hypoxic newborn lambs.
Topics: Animals; Animals, Newborn; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; Ganglia, Sym | 1983 |
Action of the Na+ ionophore monensin on vascular smooth muscle of guinea-pig aorta.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Furans; Glucose; Guinea Pigs; Hypoxia; In Vitro Te | 1984 |
Inhibitory effect of an alpha 1-adrenergic antagonist on erythropoiesis in normoxic or hypoxic mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Erythropoiesis; Erythropoietin; Female; Hypoxia; M | 1994 |
Responses of the branchial circulation to hypoxia in the Atlantic cod, Gadus morhua.
Topics: Animals; Blood Circulation; Blood Pressure; Cardiac Output; Epinephrine; Female; Fishes; Gills; Hypo | 1995 |
Transverse limb deficiency, facial clefting and hypoxic renal damage: an association with treatment of maternal hypertension?
Topics: Abnormalities, Drug-Induced; Adult; Child, Preschool; Facial Bones; Female; Fetal Death; Fetus; Huma | 1995 |
Effects of long-term high-altitude hypoxemia on alpha 1-adrenergic receptors in the ovine uterine artery.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Female; Hypoxia; Muscle Contraction; Norepinephrine | 1996 |
Effect of episodic eucapnic and hypocapnic hypoxia on systemic blood pressure in hypertension-prone rats.
Topics: Animals; Antihypertensive Agents; Arousal; Atropine; Blood Pressure; Cardiovascular Agents; Heart Ra | 1996 |
High altitude-induced changes in alpha1-adrenergic receptors and Ins(1,4,5)P3 responses in cerebral arteries.
Topics: Acclimatization; Adrenergic alpha-Antagonists; Aging; Altitude; Animals; Cerebral Arteries; Female; | 1997 |
Effect of chronic hypoxia on adrenoceptor responses of ovine foetal umbilical vessels.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Dose-Response Relati | 1998 |
Metabolic effects induced by epinephrine in Rana balcanica erythrocytes under normoxic and hypoxic conditions.
Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonis | 2000 |
Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxide dismutase.
Topics: Adrenergic alpha-Antagonists; Alanine; Animals; Animals, Newborn; Bromodeoxyuridine; Cardiotonic Age | 2000 |
Alteration in hypoxic pulmonary vasoconstriction during hypothermia in dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dogs; Female; Hypothermia, Induced; Hypoxia; Male; Norepineph | 1992 |
Effect of prazosin on hypoxemia-induced blood flow redistribution in the newborn piglet.
Topics: Animals; Animals, Newborn; Blood Circulation; Cardiac Output; Hemodynamics; Hydrogen-Ion Concentrati | 1992 |
Role of sympathetic nerve and adrenal gland in the potentiation of hypoxic pulmonary vasoconstriction during cigarette smoking.
Topics: Adrenal Glands; Adrenalectomy; Animals; Hypoxia; Male; Prazosin; Propranolol; Pulmonary Circulation; | 1992 |
Role of intrarenal angiotensin II and alpha-adrenoceptors in renal vasoconstriction with acute hypoxemia and hypercapnic acidosis in conscious dogs.
Topics: Acidosis; Acute Disease; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Dogs; Hypercapnia; H | 1991 |
Systemic hypoxia activates a coronary vasoconstrictor reflex response that is blocked by prazosin.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Gas Analysis; Coronary Circulation; Coronary Vessels; D | 1991 |
Effect of calcium antagonists and other drugs on the hypoxia-induced increase in rat right ventricular pressure.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Captopril; Female; Heart; Heart Rate; Heart Ventr | 1989 |
Effect of alpha-adrenergic blockade on the cardiovascular responses to hypoxemia and hypercapnic acidosis in conscious dogs.
Topics: Acidosis; Animals; Blood Pressure; Cardiac Output; Cardiovascular System; Central Venous Pressure; D | 1989 |
Long-chain acylcarnitines mediate the hypoxia-induced increase in alpha 1-adrenergic receptors on adult canine myocytes.
Topics: Adenosine Triphosphate; Animals; Carnitine; Carnitine O-Palmitoyltransferase; Cell Survival; Creatin | 1987 |
Ventilatory effects of domperidone, a new dopamine antagonist, in anaesthetized rabbits.
Topics: Anesthesia; Animals; Blood Gas Analysis; Carbon Dioxide; Domperidone; Dopamine Antagonists; Heart Ra | 1985 |