pk 11195 has been researched along with Sepsis in 1 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis is an organ dysfunction caused by a host's unregulated response to infection, causing long-term brain dysfunction with microglial activation, the release of inflammatory components, and mitochondrial changes." | 1.62 | The Protective Effect of PK-11195 on Cognitive Impairment in Rats Survived of Polymicrobial Sepsis. ( Abatti, MR; Barichello, T; Dal-Pizzol, F; Dominguini, D; Generoso, JS; Steckert, AV, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dominguini, D | 1 |
| Steckert, AV | 1 |
| Abatti, MR | 1 |
| Generoso, JS | 1 |
| Barichello, T | 1 |
| Dal-Pizzol, F | 1 |
1 other study available for pk 11195 and Sepsis
| Article | Year |
|---|---|
The Protective Effect of PK-11195 on Cognitive Impairment in Rats Survived of Polymicrobial Sepsis.
Topics: Animals; Brain; Cognitive Dysfunction; Cytokines; Isoquinolines; Male; Microglia; Neuroprotective Ag | 2021 |