pindolol has been researched along with Seizures in 8 studies
Pindolol: A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)
pindolol : A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study assessed the effects of concomitant administration of fluoxetine and a 5-HT1A receptor antagonist, pindolol, on focal hippocampal (HIP) seizures elicited by electrical stimulation in rats." | 7.70 | Pindolol potentiates the effect of fluoxetine on hippocampal seizures in rats. ( Hirao, N; Koshino, Y; Nakamura, M; Shiraishi, J; Wada, Y, 1999) |
| " The present study assessed the effects of concomitant administration of fluoxetine and a 5-HT1A receptor antagonist, pindolol, on focal hippocampal (HIP) seizures elicited by electrical stimulation in rats." | 3.70 | Pindolol potentiates the effect of fluoxetine on hippocampal seizures in rats. ( Hirao, N; Koshino, Y; Nakamura, M; Shiraishi, J; Wada, Y, 1999) |
| "Pindolol tended to attenuate seizure duration, especially at the 10 mg dose." | 2.67 | Prolactin and thyrotropin responses to ECT after pindolol administration. A placebo controlled study. ( Lykouras, L; Markianos, M; Papadimitriou, G; Papakostas, Y; Stefanis, C; Stefanis, N, 1993) |
| "Propranolol was the only beta blocker associated with seizure; of those who ingested more than 2 g of propranolol, two thirds had a seizure." | 1.29 | Relative toxicity of beta blockers in overdose. ( Buckley, NA; Dawson, AH; Epid, D; Reith, DM; Sayer, GP; Whyte, IM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Louis, WJ | 1 |
| Papanicolaou, J | 1 |
| Summers, RJ | 1 |
| Vajda, FJ | 1 |
| Hasni, H | 1 |
| Laborit, H | 1 |
| Clark, M | 1 |
| Weiss, SR | 1 |
| Post, RM | 1 |
| Papakostas, Y | 1 |
| Markianos, M | 1 |
| Papadimitriou, G | 1 |
| Stefanis, N | 1 |
| Lykouras, L | 1 |
| Stefanis, C | 1 |
| Reith, DM | 1 |
| Dawson, AH | 1 |
| Epid, D | 1 |
| Whyte, IM | 1 |
| Buckley, NA | 1 |
| Sayer, GP | 1 |
| Browning, RA | 1 |
| Wood, AV | 1 |
| Merrill, MA | 1 |
| Dailey, JW | 1 |
| Jobe, PC | 1 |
| Wada, Y | 1 |
| Hirao, N | 1 |
| Shiraishi, J | 1 |
| Nakamura, M | 1 |
| Koshino, Y | 1 |
| Lints, CE | 1 |
| Nyquist-Battie, C | 1 |
1 trial available for pindolol and Seizures
| Article | Year |
|---|---|
Prolactin and thyrotropin responses to ECT after pindolol administration. A placebo controlled study.
Topics: Adult; Aged; Analysis of Variance; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; M | 1993 |
7 other studies available for pindolol and Seizures
| Article | Year |
|---|---|
Role of central beta-adrenoceptors in the control of pentylenetetrazol-induced convulsions in rats.
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Female; Injections, Intraventricular; Male; P | 1982 |
[Biochemical mechanism of the epileptogenic action of folic acid injected intraventricular route and its control by pindolol].
Topics: Animals; Convulsants; Folic Acid; Folic Acid Antagonists; Injections, Intraventricular; Male; Pindol | 1982 |
Autoradiographic analysis of serotonin receptors and transporter in kindled rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Autoradiography; Cerebral Cortex; Hippoca | 1993 |
Relative toxicity of beta blockers in overdose.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Child, Preschool; Databases, Factual | 1996 |
Enhancement of the anticonvulsant effect of fluoxetine following blockade of 5-HT1A receptors.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Brain; Cyclohexylamines; Drug Interactions; Female; | 1997 |
Pindolol potentiates the effect of fluoxetine on hippocampal seizures in rats.
Topics: Animals; Drug Synergism; Fluoxetine; Hippocampus; Male; Pindolol; Rats; Rats, Wistar; Receptors, Ser | 1999 |
A possible role for beta-adrenergic receptors in the expression of audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Brain Chemistry; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred | 1985 |