Page last updated: 2024-11-02

pinacidil and Cough

pinacidil has been researched along with Cough in 4 studies

Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"In this study we have evaluated the cough reflex inhibiting potential and modulation of ASM reactivity in vitro, by K+ATP opener-pinacidil in guinea pig and cats."3.75The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways. ( Franova, S; Sutovska, M; Sutovsky, J, 2009)
"In this study we investigated whether openers of potassium channels, K+ATP--pinacidil and BK+Ca--NS1619, modulate cough reflex and airway smooth muscle (ASM) reactivity in in vivo and in vitro conditions in guinea pigs."3.74The role of potassium ion channels in cough and other reflexes of the airways. ( Franova, S; Nosalova, G; Sutovska, M, 2007)
"We investigated whether inhaled pinacidil and moguisteine inhibit capsaicin-induced coughs in guinea pigs."3.71Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs. ( Kamei, J; Morita, K; Onodera, K, 2002)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sutovska, M2
Franova, S2
Sutovsky, J1
Morita, K2
Onodera, K1
Kamei, J2
Nosalova, G1

Other Studies

4 other studies available for pinacidil and Cough

ArticleYear
The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.
    Bratislavske lekarske listy, 2009, Volume: 110, Issue:5

    Topics: Animals; Antitussive Agents; Cats; Citric Acid; Cough; Female; Glyburide; Guinea Pigs; KATP Channels

2009
Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs.
    Japanese journal of pharmacology, 2002, Volume: 89, Issue:2

    Topics: Adenosine Triphosphate; Administration, Inhalation; Animals; Antitussive Agents; Capsaicin; Codeine;

2002
The role of potassium ion channels in cough and other reflexes of the airways.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2007, Volume: 58 Suppl 5, Issue:Pt 2

    Topics: Acetylcholine; Aerosols; Airway Resistance; Animals; Benzimidazoles; Citric Acid; Cough; Glyburide;

2007
Involvement of ATP-sensitive K(+) channels in the anti-tussive effect of moguisteine.
    European journal of pharmacology, 2000, Apr-28, Volume: 395, Issue:2

    Topics: Animals; Antitussive Agents; ATP-Binding Cassette Transporters; Cough; Disease Models, Animal; Drug

2000