pinacidil and Cough
pinacidil has been researched along with Cough in 4 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study we have evaluated the cough reflex inhibiting potential and modulation of ASM reactivity in vitro, by K+ATP opener-pinacidil in guinea pig and cats." | 3.75 | The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways. ( Franova, S; Sutovska, M; Sutovsky, J, 2009) |
| "In this study we investigated whether openers of potassium channels, K+ATP--pinacidil and BK+Ca--NS1619, modulate cough reflex and airway smooth muscle (ASM) reactivity in in vivo and in vitro conditions in guinea pigs." | 3.74 | The role of potassium ion channels in cough and other reflexes of the airways. ( Franova, S; Nosalova, G; Sutovska, M, 2007) |
| "We investigated whether inhaled pinacidil and moguisteine inhibit capsaicin-induced coughs in guinea pigs." | 3.71 | Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs. ( Kamei, J; Morita, K; Onodera, K, 2002) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sutovska, M | 2 |
| Franova, S | 2 |
| Sutovsky, J | 1 |
| Morita, K | 2 |
| Onodera, K | 1 |
| Kamei, J | 2 |
| Nosalova, G | 1 |
Other Studies
4 other studies available for pinacidil and Cough
| Article | Year |
|---|---|
The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.
Topics: Animals; Antitussive Agents; Cats; Citric Acid; Cough; Female; Glyburide; Guinea Pigs; KATP Channels | 2009 |
Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs.
Topics: Adenosine Triphosphate; Administration, Inhalation; Animals; Antitussive Agents; Capsaicin; Codeine; | 2002 |
The role of potassium ion channels in cough and other reflexes of the airways.
Topics: Acetylcholine; Aerosols; Airway Resistance; Animals; Benzimidazoles; Citric Acid; Cough; Glyburide; | 2007 |
Involvement of ATP-sensitive K(+) channels in the anti-tussive effect of moguisteine.
Topics: Animals; Antitussive Agents; ATP-Binding Cassette Transporters; Cough; Disease Models, Animal; Drug | 2000 |