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phenytoin and Obesity

phenytoin has been researched along with Obesity in 30 studies

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"To examine the influence of obesity and sex on phenytoin LDs."7.91Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex. ( Alaniz, C; Burghardt, D; DasGupta, R, 2019)
"The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36."7.69Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996)
"To examine the influence of obesity and sex on phenytoin LDs."3.91Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex. ( Alaniz, C; Burghardt, D; DasGupta, R, 2019)
" Obesity does not affect serum phenytoin concentrations in pediatric patients after intravenous bolus fosphenytoin administration."3.81Impact of Body Habitus on Phenytoin Levels Following Fosphenytoin Loading Dose in Pediatric Patients. ( Messinger, MM; Moffett, BS; Wilfong, A, 2015)
"The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36."3.69Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996)
"Phenytoin is used extensively in the treatment of various forms of epilepsy, and remains the drug of choice in partial and generalized tonic-clonic seizures."3.67Phenytoin dosing in obese patients: two case reports. ( de Oca, GM; Gums, JG; Robinson, JD, 1988)
"Quantitative histomorphometric analyses of iliac crest biopsy specimens were performed after tetracycline double-labeling in 41 normal individuals, 20 hyper- and 10 hypothyroid patients, 18 patients with primary hyperparathyroidism, 20 epileptic patients receiving long-term anticonvulsant therapy, and 17 patients after jejunoileal bypass for morbid obesity."3.66Trabecular bone mineralization lag time determined by tetracycline double-labeling in normal and certain pathological conditions. ( Melsen, F; Mosekilde, L, 1980)
" Chronic dosing of propranolol may be required for efficacy; therefore, we tested the efficacy of chronic treatment with either propranolol or phenytoin on RTT mice."1.42Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs. ( Glaze, DG; Herrera, JA; Kaufmann, WE; Neul, JL; Percy, AK; Pitcher, MR; Skinner, S; Ward, CS; Wehrens, XH, 2015)
" Incorporation of the relevant physiological and biochemical changes into predictive bottom-up pharmacokinetic models in order to optimize dosage regimens may offer a logical way forward for the cases where no clinical data exist."1.37Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance. ( Aarabi, M; Allabi, AC; Almond, LM; Ghobadi, C; Jamei, M; Johnson, TN; Rostami-Hodjegan, A; Rowland-Yeo, K, 2011)
"Diazepam binding was slightly decreased in the obese as a result of lower serum albumin concentrations and elevated free fatty acids."1.27Serum protein binding and the role of increased alpha 1-acid glycoprotein in moderately obese male subjects. ( Benedek, IH; Blouin, RA; McNamara, PJ, 1984)
"Syncopal episodes were due to ventricular tachycardia and fibrillation, which were not responsive to conventional antiarrhythmic agents used in two patients."1.26Liquid protein diets and torsade de pointes. ( Gaarder, TD; Goldstein, M; Kanegae, T; Mills, H; Montgomerie, JZ; Singh, BN, 1978)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199023 (76.67)18.7374
1990's2 (6.67)18.2507
2000's0 (0.00)29.6817
2010's5 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
DasGupta, R1
Alaniz, C1
Burghardt, D1
Herrera, JA1
Ward, CS1
Pitcher, MR1
Percy, AK1
Skinner, S1
Kaufmann, WE1
Glaze, DG1
Wehrens, XH1
Neul, JL1
Janszky, J1
Horvath, R1
Komoly, S1
Messinger, MM1
Moffett, BS1
Wilfong, A1
Ghobadi, C1
Johnson, TN1
Aarabi, M1
Almond, LM1
Allabi, AC1
Rowland-Yeo, K1
Jamei, M1
Rostami-Hodjegan, A1
ROBERTS, HJ1
Huon, GF1
Brown, LB1
Benedek, IH1
Blouin, RA1
McNamara, PJ1
Peterson, DI2
Marugo, M1
Mortara, R1
Baiardi, M1
Giusti, M1
Motta, A1
Grimaldi, GP1
Melsen, F1
Mosekilde, L1
Aron, DC1
Tyrrell, JB1
Fitzgerald, PA1
Findling, JW1
Forsham, PH1
Kuranari, M1
Chiba, S1
Ashikari, Y1
Kodama, Y1
Sakata, T1
Takeyama, M1
Geleskie, P1
Kennedy, MC1
Wade, DN1
Frank-Piskorska, A1
Bogoniowska, Z1
BaraƄska, H1
Donicowa, K1
Singh, BN1
Gaarder, TD1
Kanegae, T1
Goldstein, M1
Montgomerie, JZ1
Mills, H1
Doherty, JE1
Young, RA1
Rajatanavin, R1
Moring, AF1
Braverman, LE1
de Oca, GM1
Gums, JG1
Robinson, JD1
Abernethy, DR1
Greenblatt, DJ1
Horiguchi, T1
Zweig, RW1
Sherwin, AL1
Loynd, JS1
Bock, GW1
Sokolowski, CD1
Parker, WA1
Gumnit, RJ1
Cameron, DP1
Opat, F1
Insch, S1
Perrault, M1
Dry, J1
Stahl, NL1
Teeslink, CR1
Beauchamps, G1
Greenblatt, RB1
Green, RS1
Rau, JH1
Jonas, AD1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase I, Open-Label Study to Evaluate Potential Pharmacokinetic of Orally Administered Oseltamivir in Healthy Obese Thai Adult Subjects[NCT01049763]Phase 124 participants (Actual)Interventional2010-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for phenytoin and Obesity

ArticleYear
[ZONISAMIDE: FIRST CHOICE AMONG THE FIRST-LINE ANTIEPILEPTIC DRUGS IN FOCAL EPILEPSY].
    Ideggyogyaszati szemle, 2015, May-30, Volume: 68, Issue:5-6

    Topics: Adolescent; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Administratio

2015
Bulimia: the emergence of a syndrome.
    The Australian and New Zealand journal of psychiatry, 1984, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Anorexia Nervosa; Attitude; Behavior Therapy; Body Weight; Electroencephalography

1984
Clinical use of digitalis glycosides. An update.
    Cardiology, 1985, Volume: 72, Issue:5-6

    Topics: Administration, Oral; Adrenergic beta-Antagonists; Age Factors; Anti-Arrhythmia Agents; Antihyperten

1985

Other Studies

27 other studies available for phenytoin and Obesity

ArticleYear
Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex.
    The Annals of pharmacotherapy, 2019, Volume: 53, Issue:5

    Topics: Administration, Intravenous; Adult; Aged; Anticonvulsants; Body Mass Index; Dose-Response Relationsh

2019
Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs.
    Disease models & mechanisms, 2015, Volume: 8, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Arrhythmias, Cardiac; Disease Models, Animal;

2015
Impact of Body Habitus on Phenytoin Levels Following Fosphenytoin Loading Dose in Pediatric Patients.
    Therapeutic drug monitoring, 2015, Volume: 37, Issue:6

    Topics: Adolescent; Anticonvulsants; Body Mass Index; Child; Child, Preschool; Dose-Response Relationship, D

2015
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
    Clinical pharmacokinetics, 2011, Dec-01, Volume: 50, Issue:12

    Topics: Adolescent; Adult; Aged; Benzodiazepines; Body Weights and Measures; Caffeine; Chlorzoxazone; Comput

2011
THE SYNDROME OF NARCOLEPSY AND DIABETOGENIC (FUNCTIONAL) HYPERINSULINISM. OBSERVATIONS ON 190 PATIENTS, WITH EMPHASIS UPON ITS RELATIONSHIP TO OBESITY, DIABETES MELLITUS AND CEREBRAL DYSRHYTHMIAS.
    The Journal of the Florida Medical Association. Florida Medical Association, 1963, Volume: 50

    Topics: Adolescent; Alcoholism; Arrhythmias, Cardiac; Brain; Diabetes Mellitus; Diet; Diet, Reducing; Electr

1963
Serum protein binding and the role of increased alpha 1-acid glycoprotein in moderately obese male subjects.
    British journal of clinical pharmacology, 1984, Volume: 18, Issue:6

    Topics: Adolescent; Adult; Blood Proteins; Diazepam; Humans; Lipids; Lipoproteins; Male; Obesity; Orosomucoi

1984
Phenytoin absorption following jejunoileal bypass.
    Bulletin of clinical neurosciences, 1983, Volume: 48

    Topics: Adult; Humans; Ileum; Intestinal Absorption; Jejunum; Male; Obesity; Phenytoin; Seizures

1983
[Evaluation of the metabolic action of glucagon in subjects undergoing anti-insulin therapy].
    La Clinica terapeutica, 1981, Mar-31, Volume: 96, Issue:6

    Topics: Adult; Blood Glucose; Diazoxide; Glucagon; Growth Hormone; Humans; Hyperinsulinism; Insulin; Lipids;

1981
Trabecular bone mineralization lag time determined by tetracycline double-labeling in normal and certain pathological conditions.
    Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 1980, Volume: 88, Issue:2

    Topics: Adult; Aged; Biopsy; Bone and Bones; Bone Diseases; Female; Humans; Hyperparathyroidism; Hyperthyroi

1980
Cushing's syndrome: problems in diagnosis.
    Medicine, 1981, Volume: 60, Issue:1

    Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Cortex Function Tests; Adrenocortical Hyperfunction; Adult;

1981
Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study.
    Journal of clinical pharmacy and therapeutics, 1996, Volume: 21, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Half-Life; Humans; Metabolic Clearance Rate

1996
Nutrition workup: don't forget to measure triglycerides, BMI.
    Geriatrics, 1997, Volume: 52, Issue:4

    Topics: Body Mass Index; Humans; Obesity; Phenytoin

1997
Phenytoin absorption in patients with ileojejunal bypass.
    British journal of clinical pharmacology, 1979, Volume: 7, Issue:5

    Topics: Adult; Female; Humans; Ileum; Intestinal Absorption; Jejunum; Kinetics; Male; Middle Aged; Obesity;

1979
[Insulin secretion in obese patients treated with diphenylhydantoin (DPH)].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1978, Jan-09, Volume: 33, Issue:2

    Topics: Adult; Female; Humans; Insulin; Insulin Secretion; Male; Obesity; Pancreas; Phenytoin; Secretory Rat

1978
Liquid protein diets and torsade de pointes.
    JAMA, 1978, Jul-14, Volume: 240, Issue:2

    Topics: Adult; Arrhythmias, Cardiac; Body Weight; Death, Sudden; Diet, Reducing; Dietary Proteins; Electroca

1978
Fasting induces the generation of serum thyronine-binding globulin in Zucker rats.
    Endocrinology, 1985, Volume: 116, Issue:4

    Topics: Animals; Body Weight; Fasting; Iodine Radioisotopes; Male; Obesity; Phenytoin; Rats; Rats, Mutant St

1985
Phenytoin dosing in obese patients: two case reports.
    Drug intelligence & clinical pharmacy, 1988, Volume: 22, Issue:9

    Topics: Adult; Humans; Male; Middle Aged; Obesity; Phenytoin; Seizures

1988
Phenytoin disposition in obesity. Determination of loading dose.
    Archives of neurology, 1985, Volume: 42, Issue:5

    Topics: Adult; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Obesity; Phenytoin

1985
[Clinical study on determination of blood thyroid hormone levels using the protein binding test--free thyroxine index in young children].
    Nihon Shonika Gakkai zasshi. Acta paediatrica Japonica, 1971, Volume: 75, Issue:9

    Topics: Age Factors; Androgens; Antithyroid Agents; Child; Child, Preschool; Down Syndrome; Dwarfism, Pituit

1971
Absorption of anticonvulsants after jejunoileal bypass.
    Bulletin of the Los Angeles neurological societies, 1974, Volume: 39, Issue:2

    Topics: Adult; Anticonvulsants; Diazepam; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Female; H

1974
Effects of age, sex, obesity, and pregnancy on plasma diphenylhydantoin levels.
    Epilepsia, 1974, Volume: 15, Issue:4

    Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Chromatography, Gas; Dose-Response Relationshi

1974
Diphenylhydantoin toxicity: dose-dependent blood dyscrasia.
    Neurology, 1974, Volume: 24, Issue:12

    Topics: Adult; Amenorrhea; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hypothermia; Hypothyr

1974
Studies of immunoreactive insulin secretion in NZO mice in vivo.
    Diabetologia, 1974, Volume: 10 Suppl

    Topics: Aminophylline; Animals; Antigens; Arginine; Diabetes Mellitus; Disease Models, Animal; Fasting; Gluc

1974
[Hydantoins today].
    La Revue du praticien, 1972, Dec-21, Volume: 22, Issue:33

    Topics: Arrhythmias, Cardiac; Carbohydrate Metabolism; Central Nervous System; Diabetic Neuropathies; Epilep

1972
Serum testosterone levels in hirsute women: a comparison of adrenal, ovarian and peripheral vein values.
    Obstetrics and gynecology, 1973, Volume: 41, Issue:5

    Topics: Adrenal Gland Diseases; Adrenal Glands; Adrenocortical Hyperfunction; Adult; Diabetes Complications;

1973
Treatment of compulsive eating disturbances with anticonvulsant medication.
    The American journal of psychiatry, 1974, Volume: 131, Issue:4

    Topics: Adolescent; Adult; Amphetamine; Anorexia Nervosa; Body Image; Body Weight; Compulsive Behavior; Depr

1974
The diagnostic and therapeutic use of diphenylhydantoin in the subictal state and non-epileptic dysphoria.
    International journal of neuropsychiatry, 1967, Volume: 3

    Topics: Adjustment Disorders; Antisocial Personality Disorder; Anxiety Disorders; Depression; Emotions; Epil

1967