phenytoin has been researched along with Obesity in 30 studies
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the influence of obesity and sex on phenytoin LDs." | 7.91 | Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex. ( Alaniz, C; Burghardt, D; DasGupta, R, 2019) |
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 7.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "To examine the influence of obesity and sex on phenytoin LDs." | 3.91 | Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex. ( Alaniz, C; Burghardt, D; DasGupta, R, 2019) |
| " Obesity does not affect serum phenytoin concentrations in pediatric patients after intravenous bolus fosphenytoin administration." | 3.81 | Impact of Body Habitus on Phenytoin Levels Following Fosphenytoin Loading Dose in Pediatric Patients. ( Messinger, MM; Moffett, BS; Wilfong, A, 2015) |
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 3.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "Phenytoin is used extensively in the treatment of various forms of epilepsy, and remains the drug of choice in partial and generalized tonic-clonic seizures." | 3.67 | Phenytoin dosing in obese patients: two case reports. ( de Oca, GM; Gums, JG; Robinson, JD, 1988) |
| "Quantitative histomorphometric analyses of iliac crest biopsy specimens were performed after tetracycline double-labeling in 41 normal individuals, 20 hyper- and 10 hypothyroid patients, 18 patients with primary hyperparathyroidism, 20 epileptic patients receiving long-term anticonvulsant therapy, and 17 patients after jejunoileal bypass for morbid obesity." | 3.66 | Trabecular bone mineralization lag time determined by tetracycline double-labeling in normal and certain pathological conditions. ( Melsen, F; Mosekilde, L, 1980) |
| " Chronic dosing of propranolol may be required for efficacy; therefore, we tested the efficacy of chronic treatment with either propranolol or phenytoin on RTT mice." | 1.42 | Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs. ( Glaze, DG; Herrera, JA; Kaufmann, WE; Neul, JL; Percy, AK; Pitcher, MR; Skinner, S; Ward, CS; Wehrens, XH, 2015) |
| " Incorporation of the relevant physiological and biochemical changes into predictive bottom-up pharmacokinetic models in order to optimize dosage regimens may offer a logical way forward for the cases where no clinical data exist." | 1.37 | Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance. ( Aarabi, M; Allabi, AC; Almond, LM; Ghobadi, C; Jamei, M; Johnson, TN; Rostami-Hodjegan, A; Rowland-Yeo, K, 2011) |
| "Diazepam binding was slightly decreased in the obese as a result of lower serum albumin concentrations and elevated free fatty acids." | 1.27 | Serum protein binding and the role of increased alpha 1-acid glycoprotein in moderately obese male subjects. ( Benedek, IH; Blouin, RA; McNamara, PJ, 1984) |
| "Syncopal episodes were due to ventricular tachycardia and fibrillation, which were not responsive to conventional antiarrhythmic agents used in two patients." | 1.26 | Liquid protein diets and torsade de pointes. ( Gaarder, TD; Goldstein, M; Kanegae, T; Mills, H; Montgomerie, JZ; Singh, BN, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (76.67) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DasGupta, R | 1 |
| Alaniz, C | 1 |
| Burghardt, D | 1 |
| Herrera, JA | 1 |
| Ward, CS | 1 |
| Pitcher, MR | 1 |
| Percy, AK | 1 |
| Skinner, S | 1 |
| Kaufmann, WE | 1 |
| Glaze, DG | 1 |
| Wehrens, XH | 1 |
| Neul, JL | 1 |
| Janszky, J | 1 |
| Horvath, R | 1 |
| Komoly, S | 1 |
| Messinger, MM | 1 |
| Moffett, BS | 1 |
| Wilfong, A | 1 |
| Ghobadi, C | 1 |
| Johnson, TN | 1 |
| Aarabi, M | 1 |
| Almond, LM | 1 |
| Allabi, AC | 1 |
| Rowland-Yeo, K | 1 |
| Jamei, M | 1 |
| Rostami-Hodjegan, A | 1 |
| ROBERTS, HJ | 1 |
| Huon, GF | 1 |
| Brown, LB | 1 |
| Benedek, IH | 1 |
| Blouin, RA | 1 |
| McNamara, PJ | 1 |
| Peterson, DI | 2 |
| Marugo, M | 1 |
| Mortara, R | 1 |
| Baiardi, M | 1 |
| Giusti, M | 1 |
| Motta, A | 1 |
| Grimaldi, GP | 1 |
| Melsen, F | 1 |
| Mosekilde, L | 1 |
| Aron, DC | 1 |
| Tyrrell, JB | 1 |
| Fitzgerald, PA | 1 |
| Findling, JW | 1 |
| Forsham, PH | 1 |
| Kuranari, M | 1 |
| Chiba, S | 1 |
| Ashikari, Y | 1 |
| Kodama, Y | 1 |
| Sakata, T | 1 |
| Takeyama, M | 1 |
| Geleskie, P | 1 |
| Kennedy, MC | 1 |
| Wade, DN | 1 |
| Frank-Piskorska, A | 1 |
| Bogoniowska, Z | 1 |
| Barańska, H | 1 |
| Donicowa, K | 1 |
| Singh, BN | 1 |
| Gaarder, TD | 1 |
| Kanegae, T | 1 |
| Goldstein, M | 1 |
| Montgomerie, JZ | 1 |
| Mills, H | 1 |
| Doherty, JE | 1 |
| Young, RA | 1 |
| Rajatanavin, R | 1 |
| Moring, AF | 1 |
| Braverman, LE | 1 |
| de Oca, GM | 1 |
| Gums, JG | 1 |
| Robinson, JD | 1 |
| Abernethy, DR | 1 |
| Greenblatt, DJ | 1 |
| Horiguchi, T | 1 |
| Zweig, RW | 1 |
| Sherwin, AL | 1 |
| Loynd, JS | 1 |
| Bock, GW | 1 |
| Sokolowski, CD | 1 |
| Parker, WA | 1 |
| Gumnit, RJ | 1 |
| Cameron, DP | 1 |
| Opat, F | 1 |
| Insch, S | 1 |
| Perrault, M | 1 |
| Dry, J | 1 |
| Stahl, NL | 1 |
| Teeslink, CR | 1 |
| Beauchamps, G | 1 |
| Greenblatt, RB | 1 |
| Green, RS | 1 |
| Rau, JH | 1 |
| Jonas, AD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I, Open-Label Study to Evaluate Potential Pharmacokinetic of Orally Administered Oseltamivir in Healthy Obese Thai Adult Subjects[NCT01049763] | Phase 1 | 24 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phenytoin and Obesity
| Article | Year |
|---|---|
[ZONISAMIDE: FIRST CHOICE AMONG THE FIRST-LINE ANTIEPILEPTIC DRUGS IN FOCAL EPILEPSY].
Topics: Adolescent; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Administratio | 2015 |
Bulimia: the emergence of a syndrome.
Topics: Adolescent; Adult; Anorexia Nervosa; Attitude; Behavior Therapy; Body Weight; Electroencephalography | 1984 |
Clinical use of digitalis glycosides. An update.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Age Factors; Anti-Arrhythmia Agents; Antihyperten | 1985 |
27 other studies available for phenytoin and Obesity
| Article | Year |
|---|---|
Evaluation of Intravenous Phenytoin and Fosphenytoin Loading Doses: Influence of Obesity and Sex.
Topics: Administration, Intravenous; Adult; Aged; Anticonvulsants; Body Mass Index; Dose-Response Relationsh | 2019 |
Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs.
Topics: Adrenergic beta-Antagonists; Animals; Anticonvulsants; Arrhythmias, Cardiac; Disease Models, Animal; | 2015 |
Impact of Body Habitus on Phenytoin Levels Following Fosphenytoin Loading Dose in Pediatric Patients.
Topics: Adolescent; Anticonvulsants; Body Mass Index; Child; Child, Preschool; Dose-Response Relationship, D | 2015 |
Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.
Topics: Adolescent; Adult; Aged; Benzodiazepines; Body Weights and Measures; Caffeine; Chlorzoxazone; Comput | 2011 |
THE SYNDROME OF NARCOLEPSY AND DIABETOGENIC (FUNCTIONAL) HYPERINSULINISM. OBSERVATIONS ON 190 PATIENTS, WITH EMPHASIS UPON ITS RELATIONSHIP TO OBESITY, DIABETES MELLITUS AND CEREBRAL DYSRHYTHMIAS.
Topics: Adolescent; Alcoholism; Arrhythmias, Cardiac; Brain; Diabetes Mellitus; Diet; Diet, Reducing; Electr | 1963 |
Serum protein binding and the role of increased alpha 1-acid glycoprotein in moderately obese male subjects.
Topics: Adolescent; Adult; Blood Proteins; Diazepam; Humans; Lipids; Lipoproteins; Male; Obesity; Orosomucoi | 1984 |
Phenytoin absorption following jejunoileal bypass.
Topics: Adult; Humans; Ileum; Intestinal Absorption; Jejunum; Male; Obesity; Phenytoin; Seizures | 1983 |
[Evaluation of the metabolic action of glucagon in subjects undergoing anti-insulin therapy].
Topics: Adult; Blood Glucose; Diazoxide; Glucagon; Growth Hormone; Humans; Hyperinsulinism; Insulin; Lipids; | 1981 |
Trabecular bone mineralization lag time determined by tetracycline double-labeling in normal and certain pathological conditions.
Topics: Adult; Aged; Biopsy; Bone and Bones; Bone Diseases; Female; Humans; Hyperparathyroidism; Hyperthyroi | 1980 |
Cushing's syndrome: problems in diagnosis.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Cortex Function Tests; Adrenocortical Hyperfunction; Adult; | 1981 |
Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Half-Life; Humans; Metabolic Clearance Rate | 1996 |
Nutrition workup: don't forget to measure triglycerides, BMI.
Topics: Body Mass Index; Humans; Obesity; Phenytoin | 1997 |
Phenytoin absorption in patients with ileojejunal bypass.
Topics: Adult; Female; Humans; Ileum; Intestinal Absorption; Jejunum; Kinetics; Male; Middle Aged; Obesity; | 1979 |
[Insulin secretion in obese patients treated with diphenylhydantoin (DPH)].
Topics: Adult; Female; Humans; Insulin; Insulin Secretion; Male; Obesity; Pancreas; Phenytoin; Secretory Rat | 1978 |
Liquid protein diets and torsade de pointes.
Topics: Adult; Arrhythmias, Cardiac; Body Weight; Death, Sudden; Diet, Reducing; Dietary Proteins; Electroca | 1978 |
Fasting induces the generation of serum thyronine-binding globulin in Zucker rats.
Topics: Animals; Body Weight; Fasting; Iodine Radioisotopes; Male; Obesity; Phenytoin; Rats; Rats, Mutant St | 1985 |
Phenytoin dosing in obese patients: two case reports.
Topics: Adult; Humans; Male; Middle Aged; Obesity; Phenytoin; Seizures | 1988 |
Phenytoin disposition in obesity. Determination of loading dose.
Topics: Adult; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Obesity; Phenytoin | 1985 |
[Clinical study on determination of blood thyroid hormone levels using the protein binding test--free thyroxine index in young children].
Topics: Age Factors; Androgens; Antithyroid Agents; Child; Child, Preschool; Down Syndrome; Dwarfism, Pituit | 1971 |
Absorption of anticonvulsants after jejunoileal bypass.
Topics: Adult; Anticonvulsants; Diazepam; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Female; H | 1974 |
Effects of age, sex, obesity, and pregnancy on plasma diphenylhydantoin levels.
Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Chromatography, Gas; Dose-Response Relationshi | 1974 |
Diphenylhydantoin toxicity: dose-dependent blood dyscrasia.
Topics: Adult; Amenorrhea; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hypothermia; Hypothyr | 1974 |
Studies of immunoreactive insulin secretion in NZO mice in vivo.
Topics: Aminophylline; Animals; Antigens; Arginine; Diabetes Mellitus; Disease Models, Animal; Fasting; Gluc | 1974 |
[Hydantoins today].
Topics: Arrhythmias, Cardiac; Carbohydrate Metabolism; Central Nervous System; Diabetic Neuropathies; Epilep | 1972 |
Serum testosterone levels in hirsute women: a comparison of adrenal, ovarian and peripheral vein values.
Topics: Adrenal Gland Diseases; Adrenal Glands; Adrenocortical Hyperfunction; Adult; Diabetes Complications; | 1973 |
Treatment of compulsive eating disturbances with anticonvulsant medication.
Topics: Adolescent; Adult; Amphetamine; Anorexia Nervosa; Body Image; Body Weight; Compulsive Behavior; Depr | 1974 |
The diagnostic and therapeutic use of diphenylhydantoin in the subictal state and non-epileptic dysphoria.
Topics: Adjustment Disorders; Antisocial Personality Disorder; Anxiety Disorders; Depression; Emotions; Epil | 1967 |