Page last updated: 2024-10-21

phenytoin and Malaria

phenytoin has been researched along with Malaria in 4 studies

Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

Research Excerpts

ExcerptRelevanceReference
") seizure prophylactic dose of fosphenytoin (18 mg kg-1 phenytoin sodium equivalents) were concomitantly administered to 15 African children with malaria."5.10Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration. ( Kokwaro, GO; Muchohi, SN; Newton, CR; Ogutu, BR; Otieno, GO, 2002)
" None of the dosing regimens caused toxicological manifestations other than hepatomegaly."1.27Alteration of bone marrow cell cycle kinetics by diphenylhydantoin: relationship to folate utilization and immune function. ( Boorman, GA; Hong, L; Luster, MI; Pung, O; Tucker, AN, 1985)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ogutu, BR1
Newton, CR2
Muchohi, SN1
Otieno, GO1
Kokwaro, GO1
Sadarangani, M1
Seaton, C1
Scott, JA1
Ogutu, B1
Edwards, T1
Prins, A1
Gatakaa, H1
Idro, R1
Berkley, JA1
Peshu, N1
Neville, BG1
Tucker, AN1
Hong, L1
Boorman, GA1
Pung, O1
Luster, MI1
Heischkeil, R1

Trials

1 trial available for phenytoin and Malaria

ArticleYear
Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration.
    British journal of clinical pharmacology, 2002, Volume: 54, Issue:6

    Topics: Anti-Bacterial Agents; Anticonvulsants; Area Under Curve; Cefotaxime; Child, Preschool; Chlorampheni

2002

Other Studies

3 other studies available for phenytoin and Malaria

ArticleYear
Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study.
    The Lancet. Neurology, 2008, Volume: 7, Issue:2

    Topics: Adolescent; Analysis of Variance; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Data Int

2008
Alteration of bone marrow cell cycle kinetics by diphenylhydantoin: relationship to folate utilization and immune function.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:1

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Cycle; Female; Folic Acid; Hematopoietic Stem Cells; I

1985
[Antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (Plasmodium vinckei)].
    Zeitschrift fur Tropenmedizin und Parasitologie, 1973, Volume: 24, Issue:4

    Topics: Aminopterin; Animals; Cycloheximide; Female; Folic Acid; Folic Acid Antagonists; Hydantoins; Malaria

1973