Compounds > phenylbutazone
Page last updated: 2024-11-02

phenylbutazone and Ulcer

phenylbutazone has been researched along with Ulcer in 38 studies

Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.

Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.

Research Excerpts

ExcerptRelevanceReference
"A 15-year-old Quarter Horse gelding and a 26-year-old Thoroughbred gelding were evaluated because of hematuria of 4 to 6 days' duration following prolonged oral administration of phenylbutazone."7.77Ulcerative cystitis associated with phenylbutazone administration in two horses. ( Aleman, M; Higgins, JK; Nieto, JE, 2011)
"Influence of dietary protein deficiency on the anti-inflammatory and ulcerogenic effects and on the kinetics of phenylbutazone was studied in male Sprague-Dawley rats fed ad libitum a 21% (control) or a 5% (low) protein diet for 3 weeks."7.66Influence of dietary protein on the anti-inflammatory and ulcerogenic effects and on the pharmacokinetics of phenylbutazone in rats. ( Varma, DR, 1979)
"A 15-year-old Quarter Horse gelding and a 26-year-old Thoroughbred gelding were evaluated because of hematuria of 4 to 6 days' duration following prolonged oral administration of phenylbutazone."3.77Ulcerative cystitis associated with phenylbutazone administration in two horses. ( Aleman, M; Higgins, JK; Nieto, JE, 2011)
" Anti-inflammatory and ulcerogenic activities in vivo were evaluated and compared with the standard drugs, phenylbutazone and indomethacin."3.71Synthesis and anti-inflammatory activity of 1-acetyl-5-substituted aryl-3-(beta-aminonaphthyl)-2-pyrazolines and beta-(substituted aminoethyl) amidonaphthalenes. ( Bansal, E; Kumar, A; Srivastava, VK, 2001)
"Influence of dietary protein deficiency on the anti-inflammatory and ulcerogenic effects and on the kinetics of phenylbutazone was studied in male Sprague-Dawley rats fed ad libitum a 21% (control) or a 5% (low) protein diet for 3 weeks."3.66Influence of dietary protein on the anti-inflammatory and ulcerogenic effects and on the pharmacokinetics of phenylbutazone in rats. ( Varma, DR, 1979)
" A decrease in total blood neutrophil count occurred in all horses, and was associated with toxic left shift in horses given the 2 larger dosage schedules."1.27Effects of large doses of phenylbutazone administration to horses. ( French, TW; MacKay, RJ; Mayhew, IG; Nguyen, HT, 1983)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199032 (84.21)18.7374
1990's1 (2.63)18.2507
2000's4 (10.53)29.6817
2010's1 (2.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Auzzi, G1
Bruni, F1
Cecchi, L1
Costanzo, A1
Vettori, LP1
Pirisino, R1
Corrias, M1
Ignesti, G1
Banchelli, G1
Raimondi, L1
Khanum, SA3
D, VT1
Shashikanth, S2
Firdouse, A2
Venu, TD1
Manuprasad, BK1
Mohamed, R1
Vishwanth, BS1
Khanum, NF1
Shashikanth, M1
Aleman, M1
Nieto, JE1
Higgins, JK1
CHARET, R1
SIEGEL, I1
GOSPODINOFF, A2
RAYMOND, LF2
LEVRAT, M1
LAMBERT, R1
VARRO, V4
CSERNAY, L4
JAVOR, T2
GRUBER, K1
VILARDELL, F1
TACHDJIAN, V1
CAHEN, R1
PESSONNIER, A1
JUNG, I3
FINKBINER, RB1
RICHARDSON, FM1
VILARBONET, J1
SANYAL, AK1
GUPTA, KK1
CHOWDHURY, NK1
GIETKA, J2
WISSMER, BA1
ADAMI, E1
SMEJKAL, V1
DLABAC, A1
TRCKA, V1
Mackie, BS1
Traub, JL1
Gallina, AM1
Grant, BD1
Reed, SM1
Gavin, PR1
Paulsen, LM1
MacAllister, CG1
Neoptolemos, JP1
Locke, TJ1
MacKay, RJ1
French, TW1
Nguyen, HT1
Mayhew, IG1
Miller, RM1
Dresher, LK1
Snow, DH1
Douglas, TA1
Thompson, H1
Parkins, JJ1
Holmes, PH1
Hough, ME1
Steel, CM1
Bolton, JR1
Yovich, JV1
Bansal, E1
Srivastava, VK1
Kumar, A1
Varma, DR1
Lewis, DA1
Capstick, RB1
Ancill, RJ1
Bowers, J1
Arnold, IL1
Lowrie, HS2

Other Studies

38 other studies available for phenylbutazone and Ulcer

ArticleYear
2-Phenylpyrazolo[1,5-a]pyrimidin-7-ones. A new class of nonsteroidal antiinflammatory drugs devoid of ulcerogenic activity.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Male; Phenylbutazone; Pyrazoles; Pyr

1983
Synthesis of some newer analogues of substituted dibenzoyl phenol as potent anti-inflammatory agents.
    Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Cyclooxygenase Inhibitors; In Vitro Tec

2004
Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines.
    Bioorganic & medicinal chemistry letters, 2008, Aug-01, Volume: 18, Issue:15

    Topics: Algorithms; Animals; Animals, Inbred Strains; Anti-Inflammatory Agents, Non-Steroidal; Disease Model

2008
Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines.
    Bioorganic & medicinal chemistry letters, 2008, Aug-15, Volume: 18, Issue:16

    Topics: Animals; Anti-Inflammatory Agents; Body Weight; Chemistry, Pharmaceutical; Drug Design; Edema; Ethan

2008
Ulcerative cystitis associated with phenylbutazone administration in two horses.
    Journal of the American Veterinary Medical Association, 2011, Aug-15, Volume: 239, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cystitis; Hematuria; Horse Dise

2011
Unusual reaction following use of phenylbutazone (butazolidin).
    Journal of the American Medical Association, 1953, Feb-14, Volume: 151, Issue:7

    Topics: Adrenocorticotropic Hormone; Analgesics; Chlortetracycline; Drug Eruptions; Oral Ulcer; Phenylbutazo

1953
[The ulcer-producing action of phenylbutazone].
    Il Policlinico. Sezione pratica, 1955, May-16, Volume: 62, Issue:20

    Topics: Analgesics; Peptic Ulcer; Phenylbutazone; Ulcer

1955
[Further comments on the ulcer-producing action of phenylbutazone].
    Il Policlinico. Sezione pratica, 1955, May-30, Volume: 62, Issue:22

    Topics: Analgesics; Peptic Ulcer; Phenylbutazone; Ulcer

1955
Neovascularization of the cornea due to butazolidin toxicity.
    American journal of ophthalmology, 1957, Volume: 43, Issue:2

    Topics: Cornea; Corneal Ulcer; Humans; Neovascularization, Pathologic; Phenylbutazone; Ulcer

1957
Neovascularization of the cornea due to butazolidin toxicity.
    American journal of ophthalmology, 1957, Volume: 43, Issue:2

    Topics: Cornea; Corneal Ulcer; Humans; Neovascularization, Pathologic; Phenylbutazone; Ulcer

1957
Neovascularization of the cornea due to butazolidin toxicity.
    American journal of ophthalmology, 1957, Volume: 43, Issue:2

    Topics: Cornea; Corneal Ulcer; Humans; Neovascularization, Pathologic; Phenylbutazone; Ulcer

1957
Neovascularization of the cornea due to butazolidin toxicity.
    American journal of ophthalmology, 1957, Volume: 43, Issue:2

    Topics: Cornea; Corneal Ulcer; Humans; Neovascularization, Pathologic; Phenylbutazone; Ulcer

1957
[Medically-induced ulcers in rat. I. Phenylbutazone].
    Gastroenterologia, 1959, Volume: 91, Issue:2

    Topics: Animals; Peptic Ulcer; Phenylbutazone; Rats; Ulcer

1959
Experimental phenylbutzone ulcer in dogs.
    Gastroenterology, 1959, Volume: 37

    Topics: Animals; Dogs; Peptic Ulcer; Phenylbutazone; Ulcer

1959
[Ulcer perforations during antirheumatic therapy].
    Wiener medizinische Wochenschrift (1946), 1962, Jun-23, Volume: 112

    Topics: Antirheumatic Agents; Humans; Peptic Ulcer Perforation; Phenylbutazone; Salicylic Acid; Ulcer

1962
[Ulcer hemorrhages caused by phenylbutazone in aged patients. (Study of 9 cases)].
    Revista clinica espanola, 1961, Aug-15, Volume: 82

    Topics: Humans; Peptic Ulcer Hemorrhage; Phenylbutazone; Ulcer

1961
[Pharmacological study of dihydroxyaluminum allantoinate and chlorhydroxyaluminum allantoinate. IV. Effect on experimental drug-induced ulcer].
    Annales pharmaceutiques francaises, 1963, Volume: 21

    Topics: Allantoin; Aluminum Hydroxide; Antacids; Drugs, Investigational; Phenylbutazone; Reserpine; Stomach

1963
[The role of acid secretion in the pathogenesis of experimental phenylbutazone ulcer].
    Kiserletes orvostudomany, 1962, Volume: 14

    Topics: Atropine; Histamine; Humans; Peptic Ulcer; Phenylbutazone; Ulcer; Vagotomy

1962
[The role of water retention in the pathogenesis of experimental phenylbutazone ulcer].
    Kiserletes orvostudomany, 1963, Volume: 15

    Topics: Acetazolamide; Chlorothiazide; Diuretics; Edema; Heart Failure; Organomercury Compounds; Peptic Ulce

1963
[THE SIGNIFICANCE OF PITUITARY-ADRENAL AXIS IN THE PATHOGENESIS OF EXPERIMENTAL PHENYLBUTAZONE ULCER].
    Kiserletes orvostudomany, 1963, Volume: 15

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Cortisone; Desoxycorticosterone; Dogs; Phenylbutazone;

1963
THE RESISTANT ULCER.
    Medical science, 1963, Volume: 14

    Topics: Alcoholic Beverages; Antacids; Diet; Diet Therapy; Gastrectomy; Glycopyrrolate; Humans; Parasympatho

1963
[DRUG-INDUCED ULCER (CORTICOSTEROIDS: PHENYLBUTAZONE)].
    Medicina clinica, 1963, Volume: 41

    Topics: Adrenal Cortex Hormones; Duodenal Ulcer; Endopeptidases; Gastric Juice; Humans; Pathology; Peptic Ul

1963
STUDIES ON PEPTIC ULCERATION. I. ROLE OF BANANA IN PHENYLBUTAZONE INDUCED ULCERS.
    Archives internationales de pharmacodynamie et de therapie, 1964, Jun-01, Volume: 149

    Topics: Diet; Flavoring Agents; Fruit; Guinea Pigs; Musa; Pathology; Peptic Ulcer; Phenylbutazone; Research;

1964
[EFFECT OF BUTAZOLIDIN ON THE GASTRIC MUCOSA (ATTEMPTED CLASSIFICATION OF THE MECHANISM OF ULCER FOLLOWING BUTAZOLIDIN THERAPY)].
    Polskie Archiwum Medycyny Wewnetrznej, 1964, Volume: 34

    Topics: Gastric Mucosa; Humans; Peptic Ulcer; Pharmacology; Phenylbutazone; Rats; Research; Toxicology; Ulce

1964
[EFFECT OF BUTAZOLIDIN ON THE GASTRIC MUSA (ATTEMPTED CLARIFICATION OF THE MECHANISM OF ULCER FOLLOWING THE ADMINISTRATION OF BUTAZOLIDIN. II. BEHAVIOR OF MUCOPOLYSACCHARIDES IN THE GASTRIC MUCOSA].
    Polskie Archiwum Medycyny Wewnetrznej, 1964, Volume: 34

    Topics: Carbohydrate Metabolism; Gastric Mucosa; Glycosaminoglycans; Humans; Musa; Peptic Ulcer; Pharmacolog

1964
A NEW WAY IN ULCER THERAPY?
    Current therapeutic research, clinical and experimental, 1965, Volume: 7

    Topics: Drug Therapy; Histamine; Peptic Ulcer; Pharmacology; Phenylbutazone; Prednisolone; Rats; Research; R

1965
THE INFLUENCE OF A NEW RESERPINE DERIVATIVE, METHOXYPHENOSERPINE, ON EXPERIMENTAL ULCERS AND GASTRIC SECRETION IN RATS.
    International journal of neuropharmacology, 1964, Volume: 3

    Topics: Cathartics; Gastric Juice; Pepsin A; Peptic Ulcer; Pharmacology; Phenylbutazone; Pylorus; Rats; Rese

1964
Drug-induced ulcer of the lip.
    The British journal of dermatology, 1967, Volume: 79, Issue:2

    Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Carcinoma, Squamous Cell; Chlorpromazine; D

1967
Phenylbutazone toxicosis in the foal.
    American journal of veterinary research, 1983, Volume: 44, Issue:8

    Topics: Animals; Barium Sulfate; Colonic Diseases; Diarrhea; Female; Gastric Mucosa; Gastroscopy; Horse Dise

1983
Effects of toxic doses of phenylbutazone in ponies.
    American journal of veterinary research, 1983, Volume: 44, Issue:12

    Topics: Administration, Oral; Animals; Gastrointestinal Diseases; Horse Diseases; Horses; Injections, Intrav

1983
Recurrent small bowel obstruction associated with phenylbutazone.
    The British journal of surgery, 1983, Volume: 70, Issue:4

    Topics: Aged; Female; Humans; Ileal Diseases; Intestinal Obstruction; Phenylbutazone; Ulcer

1983
Effects of large doses of phenylbutazone administration to horses.
    American journal of veterinary research, 1983, Volume: 44, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Cat Diseases; Cats; Dog Diseases; Dogs; Female; Gastric Mucosa; G

1983
Equine ulcerative lymphangitis caused by Pasteurella hemolytica (2 case reports).
    Veterinary medicine, small animal clinician : VM, SAC, 1981, Volume: 76, Issue:9

    Topics: Animals; Chloramphenicol; Furosemide; Horse Diseases; Horses; Lymphangitis; Male; Pasteurella Infect

1981
Phenylbutazone toxicity in ponies.
    The Veterinary record, 1980, Jan-19, Volume: 106, Issue:3

    Topics: Animals; Gastrointestinal Diseases; Horse Diseases; Horses; Hypoproteinemia; Phenylbutazone; Protein

1980
Ulceration and stricture of the right dorsal colon after phenylbutazone administration in four horses.
    Australian veterinary journal, 1999, Volume: 77, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Constriction, Pathologic; Fatal

1999
Synthesis and anti-inflammatory activity of 1-acetyl-5-substituted aryl-3-(beta-aminonaphthyl)-2-pyrazolines and beta-(substituted aminoethyl) amidonaphthalenes.
    European journal of medicinal chemistry, 2001, Volume: 36, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Chalcone; Female; Indomethacin; Lethal Dose 50; Male; Mice; Napht

2001
Influence of dietary protein on the anti-inflammatory and ulcerogenic effects and on the pharmacokinetics of phenylbutazone in rats.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 211, Issue:2

    Topics: Animals; Body Weight; Carrageenan; Dietary Proteins; Edema; Kinetics; Male; Phenylbutazone; Protein-

1979
The action of azapropazone, oxyphenbutazone and phenylbutazone on lysosomes.
    The Journal of pharmacy and pharmacology, 1971, Volume: 23, Issue:12

    Topics: Acid Phosphatase; Animals; Female; Glycoside Hydrolases; Histocytochemistry; Ileum; In Vitro Techniq

1971
Necrotizing scleral degeneration treated with a graft of autogenous fascia lata.
    Journal of the Tennessee Medical Association, 1970, Volume: 63, Issue:10

    Topics: Aged; Conjunctiva; Eye Diseases; Fascia; Female; Humans; Necrosis; Panophthalmitis; Phenylbutazone;

1970
3-phenylcinnolines. II. The preparation of 4-amino derivatives.
    Journal of medicinal chemistry, 1966, Volume: 9, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Chemistry, Organic; Dicarboxylic Acids; Diuresis;

1966
3-phenylcinnolines. I. Some reactions and derivatives of 3-phenylcinnoline-4-carboxylic acids.
    Journal of medicinal chemistry, 1966, Volume: 9, Issue:5

    Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Blood Pressure; Chemistry, Organic; Dicarboxylic A

1966