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phenylbutazone and Ulcer

phenylbutazone has been researched along with Ulcer in 38 studies

Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.
phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.

Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.

Research Excerpts

Excerpt	Relevance	Reference
"A 15-year-old Quarter Horse gelding and a 26-year-old Thoroughbred gelding were evaluated because of hematuria of 4 to 6 days' duration following prolonged oral administration of phenylbutazone."	7.77	Ulcerative cystitis associated with phenylbutazone administration in two horses. ( Aleman, M; Higgins, JK; Nieto, JE, 2011)
"Influence of dietary protein deficiency on the anti-inflammatory and ulcerogenic effects and on the kinetics of phenylbutazone was studied in male Sprague-Dawley rats fed ad libitum a 21% (control) or a 5% (low) protein diet for 3 weeks."	7.66	Influence of dietary protein on the anti-inflammatory and ulcerogenic effects and on the pharmacokinetics of phenylbutazone in rats. ( Varma, DR, 1979)
"A 15-year-old Quarter Horse gelding and a 26-year-old Thoroughbred gelding were evaluated because of hematuria of 4 to 6 days' duration following prolonged oral administration of phenylbutazone."	3.77	Ulcerative cystitis associated with phenylbutazone administration in two horses. ( Aleman, M; Higgins, JK; Nieto, JE, 2011)
" Anti-inflammatory and ulcerogenic activities in vivo were evaluated and compared with the standard drugs, phenylbutazone and indomethacin."	3.71	Synthesis and anti-inflammatory activity of 1-acetyl-5-substituted aryl-3-(beta-aminonaphthyl)-2-pyrazolines and beta-(substituted aminoethyl) amidonaphthalenes. ( Bansal, E; Kumar, A; Srivastava, VK, 2001)
"Influence of dietary protein deficiency on the anti-inflammatory and ulcerogenic effects and on the kinetics of phenylbutazone was studied in male Sprague-Dawley rats fed ad libitum a 21% (control) or a 5% (low) protein diet for 3 weeks."	3.66	Influence of dietary protein on the anti-inflammatory and ulcerogenic effects and on the pharmacokinetics of phenylbutazone in rats. ( Varma, DR, 1979)
" A decrease in total blood neutrophil count occurred in all horses, and was associated with toxic left shift in horses given the 2 larger dosage schedules."	1.27	Effects of large doses of phenylbutazone administration to horses. ( French, TW; MacKay, RJ; Mayhew, IG; Nguyen, HT, 1983)

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	32 (84.21)	18.7374
1990's	1 (2.63)	18.2507
2000's	4 (10.53)	29.6817
2010's	1 (2.63)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Auzzi, G	1
Bruni, F	1
Cecchi, L	1
Costanzo, A	1
Vettori, LP	1
Pirisino, R	1
Corrias, M	1
Ignesti, G	1
Banchelli, G	1
Raimondi, L	1
Khanum, SA	3
D, VT	1
Shashikanth, S	2
Firdouse, A	2
Venu, TD	1
Manuprasad, BK	1
Mohamed, R	1
Vishwanth, BS	1
Khanum, NF	1
Shashikanth, M	1
Aleman, M	1
Nieto, JE	1
Higgins, JK	1
CHARET, R	1
SIEGEL, I	1
GOSPODINOFF, A	2
RAYMOND, LF	2
LEVRAT, M	1
LAMBERT, R	1
VARRO, V	4
CSERNAY, L	4
JAVOR, T	2
GRUBER, K	1
VILARDELL, F	1
TACHDJIAN, V	1
CAHEN, R	1
PESSONNIER, A	1
JUNG, I	3
FINKBINER, RB	1
RICHARDSON, FM	1
VILARBONET, J	1
SANYAL, AK	1
GUPTA, KK	1
CHOWDHURY, NK	1
GIETKA, J	2
WISSMER, BA	1
ADAMI, E	1
SMEJKAL, V	1
DLABAC, A	1
TRCKA, V	1
Mackie, BS	1
Traub, JL	1
Gallina, AM	1
Grant, BD	1
Reed, SM	1
Gavin, PR	1
Paulsen, LM	1
MacAllister, CG	1
Neoptolemos, JP	1
Locke, TJ	1
MacKay, RJ	1
French, TW	1
Nguyen, HT	1
Mayhew, IG	1
Miller, RM	1
Dresher, LK	1
Snow, DH	1
Douglas, TA	1
Thompson, H	1
Parkins, JJ	1
Holmes, PH	1
Hough, ME	1
Steel, CM	1
Bolton, JR	1
Yovich, JV	1
Bansal, E	1
Srivastava, VK	1
Kumar, A	1
Varma, DR	1
Lewis, DA	1
Capstick, RB	1
Ancill, RJ	1
Bowers, J	1
Arnold, IL	1
Lowrie, HS	2

Other Studies

38 other studies available for phenylbutazone and Ulcer

Article	Year
2-Phenylpyrazolo[1,5-a]pyrimidin-7-ones. A new class of nonsteroidal antiinflammatory drugs devoid of ulcerogenic activity. Journal of medicinal chemistry, 1983, Volume: 26, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Indomethacin; Male; Phenylbutazone; Pyrazoles; Pyr	1983
Synthesis of some newer analogues of substituted dibenzoyl phenol as potent anti-inflammatory agents. Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Cyclooxygenase Inhibitors; In Vitro Tec	2004
Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines. Bioorganic & medicinal chemistry letters, 2008, Aug-01, Volume: 18, Issue:15 Topics: Algorithms; Animals; Animals, Inbred Strains; Anti-Inflammatory Agents, Non-Steroidal; Disease Model	2008
Synthesis and anti-inflammatory activity of 2-aryloxy methyl oxazolines. Bioorganic & medicinal chemistry letters, 2008, Aug-15, Volume: 18, Issue:16 Topics: Animals; Anti-Inflammatory Agents; Body Weight; Chemistry, Pharmaceutical; Drug Design; Edema; Ethan	2008
Ulcerative cystitis associated with phenylbutazone administration in two horses. Journal of the American Veterinary Medical Association, 2011, Aug-15, Volume: 239, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cystitis; Hematuria; Horse Dise	2011
Unusual reaction following use of phenylbutazone (butazolidin). Journal of the American Medical Association, 1953, Feb-14, Volume: 151, Issue:7 Topics: Adrenocorticotropic Hormone; Analgesics; Chlortetracycline; Drug Eruptions; Oral Ulcer; Phenylbutazo	1953
[The ulcer-producing action of phenylbutazone]. Il Policlinico. Sezione pratica, 1955, May-16, Volume: 62, Issue:20 Topics: Analgesics; Peptic Ulcer; Phenylbutazone; Ulcer	1955
[Further comments on the ulcer-producing action of phenylbutazone]. Il Policlinico. Sezione pratica, 1955, May-30, Volume: 62, Issue:22 Topics: Analgesics; Peptic Ulcer; Phenylbutazone; Ulcer	1955
Neovascularization of the cornea due to butazolidin toxicity. American journal of ophthalmology, 1957, Volume: 43, Issue:2 Topics: Cornea; Corneal Ulcer; Humans; Neovascularization, Pathologic; Phenylbutazone; Ulcer	1957
Neovascularization of the cornea due to butazolidin toxicity. American journal of ophthalmology, 1957, Volume: 43, Issue:2 Topics: Cornea; Corneal Ulcer; Humans; Neovascularization, Pathologic; Phenylbutazone; Ulcer	1957
Neovascularization of the cornea due to butazolidin toxicity. American journal of ophthalmology, 1957, Volume: 43, Issue:2 Topics: Cornea; Corneal Ulcer; Humans; Neovascularization, Pathologic; Phenylbutazone; Ulcer	1957
Neovascularization of the cornea due to butazolidin toxicity. American journal of ophthalmology, 1957, Volume: 43, Issue:2 Topics: Cornea; Corneal Ulcer; Humans; Neovascularization, Pathologic; Phenylbutazone; Ulcer	1957
[Medically-induced ulcers in rat. I. Phenylbutazone]. Gastroenterologia, 1959, Volume: 91, Issue:2 Topics: Animals; Peptic Ulcer; Phenylbutazone; Rats; Ulcer	1959
Experimental phenylbutzone ulcer in dogs. Gastroenterology, 1959, Volume: 37 Topics: Animals; Dogs; Peptic Ulcer; Phenylbutazone; Ulcer	1959
[Ulcer perforations during antirheumatic therapy]. Wiener medizinische Wochenschrift (1946), 1962, Jun-23, Volume: 112 Topics: Antirheumatic Agents; Humans; Peptic Ulcer Perforation; Phenylbutazone; Salicylic Acid; Ulcer	1962
[Ulcer hemorrhages caused by phenylbutazone in aged patients. (Study of 9 cases)]. Revista clinica espanola, 1961, Aug-15, Volume: 82 Topics: Humans; Peptic Ulcer Hemorrhage; Phenylbutazone; Ulcer	1961
[Pharmacological study of dihydroxyaluminum allantoinate and chlorhydroxyaluminum allantoinate. IV. Effect on experimental drug-induced ulcer]. Annales pharmaceutiques francaises, 1963, Volume: 21 Topics: Allantoin; Aluminum Hydroxide; Antacids; Drugs, Investigational; Phenylbutazone; Reserpine; Stomach	1963
[The role of acid secretion in the pathogenesis of experimental phenylbutazone ulcer]. Kiserletes orvostudomany, 1962, Volume: 14 Topics: Atropine; Histamine; Humans; Peptic Ulcer; Phenylbutazone; Ulcer; Vagotomy	1962
[The role of water retention in the pathogenesis of experimental phenylbutazone ulcer]. Kiserletes orvostudomany, 1963, Volume: 15 Topics: Acetazolamide; Chlorothiazide; Diuretics; Edema; Heart Failure; Organomercury Compounds; Peptic Ulce	1963
[THE SIGNIFICANCE OF PITUITARY-ADRENAL AXIS IN THE PATHOGENESIS OF EXPERIMENTAL PHENYLBUTAZONE ULCER]. Kiserletes orvostudomany, 1963, Volume: 15 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Cortisone; Desoxycorticosterone; Dogs; Phenylbutazone;	1963
THE RESISTANT ULCER. Medical science, 1963, Volume: 14 Topics: Alcoholic Beverages; Antacids; Diet; Diet Therapy; Gastrectomy; Glycopyrrolate; Humans; Parasympatho	1963
[DRUG-INDUCED ULCER (CORTICOSTEROIDS: PHENYLBUTAZONE)]. Medicina clinica, 1963, Volume: 41 Topics: Adrenal Cortex Hormones; Duodenal Ulcer; Endopeptidases; Gastric Juice; Humans; Pathology; Peptic Ul	1963
STUDIES ON PEPTIC ULCERATION. I. ROLE OF BANANA IN PHENYLBUTAZONE INDUCED ULCERS. Archives internationales de pharmacodynamie et de therapie, 1964, Jun-01, Volume: 149 Topics: Diet; Flavoring Agents; Fruit; Guinea Pigs; Musa; Pathology; Peptic Ulcer; Phenylbutazone; Research;	1964
[EFFECT OF BUTAZOLIDIN ON THE GASTRIC MUCOSA (ATTEMPTED CLASSIFICATION OF THE MECHANISM OF ULCER FOLLOWING BUTAZOLIDIN THERAPY)]. Polskie Archiwum Medycyny Wewnetrznej, 1964, Volume: 34 Topics: Gastric Mucosa; Humans; Peptic Ulcer; Pharmacology; Phenylbutazone; Rats; Research; Toxicology; Ulce	1964
[EFFECT OF BUTAZOLIDIN ON THE GASTRIC MUSA (ATTEMPTED CLARIFICATION OF THE MECHANISM OF ULCER FOLLOWING THE ADMINISTRATION OF BUTAZOLIDIN. II. BEHAVIOR OF MUCOPOLYSACCHARIDES IN THE GASTRIC MUCOSA]. Polskie Archiwum Medycyny Wewnetrznej, 1964, Volume: 34 Topics: Carbohydrate Metabolism; Gastric Mucosa; Glycosaminoglycans; Humans; Musa; Peptic Ulcer; Pharmacolog	1964
A NEW WAY IN ULCER THERAPY? Current therapeutic research, clinical and experimental, 1965, Volume: 7 Topics: Drug Therapy; Histamine; Peptic Ulcer; Pharmacology; Phenylbutazone; Prednisolone; Rats; Research; R	1965
THE INFLUENCE OF A NEW RESERPINE DERIVATIVE, METHOXYPHENOSERPINE, ON EXPERIMENTAL ULCERS AND GASTRIC SECRETION IN RATS. International journal of neuropharmacology, 1964, Volume: 3 Topics: Cathartics; Gastric Juice; Pepsin A; Peptic Ulcer; Pharmacology; Phenylbutazone; Pylorus; Rats; Rese	1964
Drug-induced ulcer of the lip. The British journal of dermatology, 1967, Volume: 79, Issue:2 Topics: Administration, Topical; Aged; Anti-Inflammatory Agents; Carcinoma, Squamous Cell; Chlorpromazine; D	1967
Phenylbutazone toxicosis in the foal. American journal of veterinary research, 1983, Volume: 44, Issue:8 Topics: Animals; Barium Sulfate; Colonic Diseases; Diarrhea; Female; Gastric Mucosa; Gastroscopy; Horse Dise	1983
Effects of toxic doses of phenylbutazone in ponies. American journal of veterinary research, 1983, Volume: 44, Issue:12 Topics: Administration, Oral; Animals; Gastrointestinal Diseases; Horse Diseases; Horses; Injections, Intrav	1983
Recurrent small bowel obstruction associated with phenylbutazone. The British journal of surgery, 1983, Volume: 70, Issue:4 Topics: Aged; Female; Humans; Ileal Diseases; Intestinal Obstruction; Phenylbutazone; Ulcer	1983
Effects of large doses of phenylbutazone administration to horses. American journal of veterinary research, 1983, Volume: 44, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Cat Diseases; Cats; Dog Diseases; Dogs; Female; Gastric Mucosa; G	1983
Equine ulcerative lymphangitis caused by Pasteurella hemolytica (2 case reports). Veterinary medicine, small animal clinician : VM, SAC, 1981, Volume: 76, Issue:9 Topics: Animals; Chloramphenicol; Furosemide; Horse Diseases; Horses; Lymphangitis; Male; Pasteurella Infect	1981
Phenylbutazone toxicity in ponies. The Veterinary record, 1980, Jan-19, Volume: 106, Issue:3 Topics: Animals; Gastrointestinal Diseases; Horse Diseases; Horses; Hypoproteinemia; Phenylbutazone; Protein	1980
Ulceration and stricture of the right dorsal colon after phenylbutazone administration in four horses. Australian veterinary journal, 1999, Volume: 77, Issue:12 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Constriction, Pathologic; Fatal	1999
Synthesis and anti-inflammatory activity of 1-acetyl-5-substituted aryl-3-(beta-aminonaphthyl)-2-pyrazolines and beta-(substituted aminoethyl) amidonaphthalenes. European journal of medicinal chemistry, 2001, Volume: 36, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Chalcone; Female; Indomethacin; Lethal Dose 50; Male; Mice; Napht	2001
Influence of dietary protein on the anti-inflammatory and ulcerogenic effects and on the pharmacokinetics of phenylbutazone in rats. The Journal of pharmacology and experimental therapeutics, 1979, Volume: 211, Issue:2 Topics: Animals; Body Weight; Carrageenan; Dietary Proteins; Edema; Kinetics; Male; Phenylbutazone; Protein-	1979
The action of azapropazone, oxyphenbutazone and phenylbutazone on lysosomes. The Journal of pharmacy and pharmacology, 1971, Volume: 23, Issue:12 Topics: Acid Phosphatase; Animals; Female; Glycoside Hydrolases; Histocytochemistry; Ileum; In Vitro Techniq	1971
Necrotizing scleral degeneration treated with a graft of autogenous fascia lata. Journal of the Tennessee Medical Association, 1970, Volume: 63, Issue:10 Topics: Aged; Conjunctiva; Eye Diseases; Fascia; Female; Humans; Necrosis; Panophthalmitis; Phenylbutazone;	1970
3-phenylcinnolines. II. The preparation of 4-amino derivatives. Journal of medicinal chemistry, 1966, Volume: 9, Issue:5 Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Chemistry, Organic; Dicarboxylic Acids; Diuresis;	1966
3-phenylcinnolines. I. Some reactions and derivatives of 3-phenylcinnoline-4-carboxylic acids. Journal of medicinal chemistry, 1966, Volume: 9, Issue:5 Topics: Adrenalectomy; Animals; Anti-Inflammatory Agents; Blood Pressure; Chemistry, Organic; Dicarboxylic A	1966