pentylenetetrazole has been researched along with Cerebral Cortical Dysplasia in 6 studies
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.
pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "LCM and LEV were both effective against seizures induced by PTZ." | 5.46 | Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia. ( Alexopoulos, AV; Gonzalez-Martinez, J; Najm, IM; Nemes, AD; O'Dwyer, R; Ying, Z, 2017) |
| "LCM and LEV were both effective against seizures induced by PTZ." | 1.46 | Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia. ( Alexopoulos, AV; Gonzalez-Martinez, J; Najm, IM; Nemes, AD; O'Dwyer, R; Ying, Z, 2017) |
| "We examined the seizure susceptibility of these mice to determine if the presence (BXD29-Trl4(lps-2J)/J) or absence (C57BL/10J) of p-ACC, in strains with MCD, confers a differential response to chemi-convulsive treatment." | 1.39 | Differential seizure response in two models of cortical heterotopia. ( Gabel, LA; Ibanez, N; Manglani, M; Ramos, RL; Roberts, J; Rosen, GD, 2013) |
| "The present study showed that epileptic seizures induced by convulsive PTZ challenge during kindling-mediated epileptogenesis in the presence of CD changed both functional and ultrastructural properties of the BBB and considerably enhanced transendothelial vesicular transport, while paracellular pathway was apparently not involved in this setting." | 1.35 | Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia. ( Ahishali, B; Arican, N; Bilgic, B; Ekizoglu, O; Elmas, I; Gurses, C; Kalayci, R; Kaya, M; Kemikler, G; Kucuk, M; Oku, B; Orhan, N; Ustek, D, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nemes, AD | 1 |
| O'Dwyer, R | 1 |
| Najm, IM | 2 |
| Ying, Z | 1 |
| Gonzalez-Martinez, J | 1 |
| Alexopoulos, AV | 2 |
| Ma, L | 1 |
| Yang, F | 1 |
| Zhao, R | 1 |
| Li, L | 1 |
| Kang, X | 1 |
| Xiao, L | 1 |
| Jiang, W | 1 |
| Oghlakian, RO | 1 |
| Tilelli, CQ | 1 |
| Hiremath, GK | 1 |
| Gurses, C | 2 |
| Ekizoglu, O | 2 |
| Orhan, N | 2 |
| Ustek, D | 2 |
| Arican, N | 2 |
| Ahishali, B | 2 |
| Elmas, I | 2 |
| Kucuk, M | 2 |
| Bilgic, B | 2 |
| Kemikler, G | 2 |
| Kalayci, R | 2 |
| Karadeniz, A | 1 |
| Kaya, M | 2 |
| Gabel, LA | 1 |
| Manglani, M | 1 |
| Ibanez, N | 1 |
| Roberts, J | 1 |
| Ramos, RL | 1 |
| Rosen, GD | 1 |
| Oku, B | 1 |
6 other studies available for pentylenetetrazole and Cerebral Cortical Dysplasia
| Article | Year |
|---|---|
Treatment with lacosamide impedes generalized seizures in a rodent model of cortical dysplasia.
Topics: Acetamides; Animals; Anticonvulsants; Electroencephalography; Female; GABA Antagonists; Lacosamide; | 2017 |
Quetiapine attenuates cognitive impairment and decreases seizure susceptibility possibly through promoting myelin development in a rat model of malformations of cortical development.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cerebral Cortex; Cognition Disorders; Corpus Callosum; D | 2015 |
Single injection of a low dose of pentylenetetrazole leads to epileptogenesis in an animal model of cortical dysplasia.
Topics: Age Factors; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Electroencephalography; | 2009 |
Levetiracetam decreases the seizure activity and blood-brain barrier permeability in pentylenetetrazole-kindled rats with cortical dysplasia.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Capillary Permeability; Endothelium; Fluoresce | 2009 |
Differential seizure response in two models of cortical heterotopia.
Topics: Agenesis of Corpus Callosum; Animals; Cerebral Cortex; Choristoma; Convulsants; Disease Models, Anim | 2013 |
Morphological and functional changes of blood-brain barrier in kindled rats with cortical dysplasia.
Topics: Animals; Blood-Brain Barrier; Capillary Permeability; Disease Models, Animal; Female; Glial Fibrilla | 2008 |