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pentoxifylline and Neuroblastoma

pentoxifylline has been researched along with Neuroblastoma in 6 studies

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"We described here that pentoxifylline (PTX), which is well known to counteract tumor necrosis factor alpha (TNF alpha)-mediated inflammatory responses, augmented TNF alpha-induced neuroblastoma cell differentiation in conjunction with growth inhibition and cell-cycle arrest in G1 phase."7.69Pentoxifylline augments but does not antagonize TNF alpha-mediated neuroblastoma cell differentiation: modulation of calcium mobilization but not cAMP. ( Chuen, HL; Shaio, MF; Yang, KD, 1995)
"Pentoxifylline (PTX) has been reported to have both direct and indirect anti-tumor effects in experimental tumor models."5.30The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma. ( Amirkhosravi, A; Biggerstaff, J; Francis, JL; Malik, Z; May, K; Warnes, G, 1997)
" Here we have analyzed naturally occurring MTXs caffeine, theobromine, theophylline, and the synthetic MTXs pentoxifylline and propentofylline also used as drugs in different neuroblastoma cell lines."4.12Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells. ( Bachmann, CM; Griebsch, LV; Grimm, HS; Grimm, MOW; Hartmann, T; Janitschke, D; Lauer, AA; Pilz, SM; Theiss, EL; Winkler, J, 2022)
"We described here that pentoxifylline (PTX), which is well known to counteract tumor necrosis factor alpha (TNF alpha)-mediated inflammatory responses, augmented TNF alpha-induced neuroblastoma cell differentiation in conjunction with growth inhibition and cell-cycle arrest in G1 phase."3.69Pentoxifylline augments but does not antagonize TNF alpha-mediated neuroblastoma cell differentiation: modulation of calcium mobilization but not cAMP. ( Chuen, HL; Shaio, MF; Yang, KD, 1995)
" pentoxifylline (Px) (which also were found to release PgI2 and t-PA) inhibited human tumor implant induced angiogenesis and reduced spontaneous metastases in 3 transplantable murine tumors (Furth-Columbia Wilms' tumor in Furth-Wistar rats, C-1300 neuroblastoma in A/J mice and HM-Kim mammary carcinoma in Wistar rats) but not in the NIH adenocarcinoma in Balb/c mice."3.68Studies on tumor induced angiogenesis. ( Ambrus, CM; Ambrus, JL; Forgach, P; Halpern, J; Niswander, P; Sayyid, S; Stadler, S; Toumbis, C, 1992)
"Pentoxifylline (PTX) has been reported to have both direct and indirect anti-tumor effects in experimental tumor models."1.30The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma. ( Amirkhosravi, A; Biggerstaff, J; Francis, JL; Malik, Z; May, K; Warnes, G, 1997)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Janitschke, D2
Lauer, AA2
Bachmann, CM2
Winkler, J1
Griebsch, LV1
Pilz, SM1
Theiss, EL1
Grimm, HS2
Hartmann, T2
Grimm, MOW2
Seyfried, M1
Yang, KD2
Chuen, HL1
Shaio, MF2
Wang, CL1
Wu, NC1
Stone, RM1
Amirkhosravi, A1
Warnes, G1
Biggerstaff, J1
Malik, Z1
May, K1
Francis, JL1
Ambrus, JL1
Ambrus, CM1
Forgach, P1
Stadler, S1
Halpern, J1
Sayyid, S1
Niswander, P1
Toumbis, C1

Other Studies

6 other studies available for pentoxifylline and Neuroblastoma

ArticleYear
Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells.
    International journal of molecular sciences, 2022, Feb-18, Volume: 23, Issue:4

    Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Cholesterol; Humans; Lipids; Neural Stem Cells; Neuro

2022
Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells.
    International journal of molecular sciences, 2020, Nov-27, Volume: 21, Issue:23

    Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Gene Expression Regulation; Genes, Essential; Humans;

2020
Pentoxifylline augments but does not antagonize TNF alpha-mediated neuroblastoma cell differentiation: modulation of calcium mobilization but not cAMP.
    Biochemical and biophysical research communications, 1995, Jun-26, Volume: 211, Issue:3

    Topics: Acetylcholine; Calcium; Calcium Channel Blockers; Cell Cycle; Cell Differentiation; Cyclic AMP; Down

1995
Neuroblastoma cell-mediated leukocyte chemotaxis: lineage-specific differentiation of interleukin-8 expression.
    Experimental cell research, 1994, Volume: 211, Issue:1

    Topics: Cell Communication; Cell Differentiation; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; E

1994
The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma.
    Clinical & experimental metastasis, 1997, Volume: 15, Issue:4

    Topics: Animals; Carcinogenicity Tests; Cell Adhesion; Cell Cycle; Cell Division; Cell Membrane; Female; Fib

1997
Studies on tumor induced angiogenesis.
    EXS, 1992, Volume: 61

    Topics: Adenocarcinoma; Aminocaproic Acid; Animals; Cornea; Ditiocarb; Humans; Kidney Neoplasms; Macaca; Mam

1992
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