pentoxifylline and Neuroblastoma
pentoxifylline has been researched along with Neuroblastoma in 6 studies
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"We described here that pentoxifylline (PTX), which is well known to counteract tumor necrosis factor alpha (TNF alpha)-mediated inflammatory responses, augmented TNF alpha-induced neuroblastoma cell differentiation in conjunction with growth inhibition and cell-cycle arrest in G1 phase." | 7.69 | Pentoxifylline augments but does not antagonize TNF alpha-mediated neuroblastoma cell differentiation: modulation of calcium mobilization but not cAMP. ( Chuen, HL; Shaio, MF; Yang, KD, 1995) |
"Pentoxifylline (PTX) has been reported to have both direct and indirect anti-tumor effects in experimental tumor models." | 5.30 | The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma. ( Amirkhosravi, A; Biggerstaff, J; Francis, JL; Malik, Z; May, K; Warnes, G, 1997) |
" Here we have analyzed naturally occurring MTXs caffeine, theobromine, theophylline, and the synthetic MTXs pentoxifylline and propentofylline also used as drugs in different neuroblastoma cell lines." | 4.12 | Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells. ( Bachmann, CM; Griebsch, LV; Grimm, HS; Grimm, MOW; Hartmann, T; Janitschke, D; Lauer, AA; Pilz, SM; Theiss, EL; Winkler, J, 2022) |
"We described here that pentoxifylline (PTX), which is well known to counteract tumor necrosis factor alpha (TNF alpha)-mediated inflammatory responses, augmented TNF alpha-induced neuroblastoma cell differentiation in conjunction with growth inhibition and cell-cycle arrest in G1 phase." | 3.69 | Pentoxifylline augments but does not antagonize TNF alpha-mediated neuroblastoma cell differentiation: modulation of calcium mobilization but not cAMP. ( Chuen, HL; Shaio, MF; Yang, KD, 1995) |
" pentoxifylline (Px) (which also were found to release PgI2 and t-PA) inhibited human tumor implant induced angiogenesis and reduced spontaneous metastases in 3 transplantable murine tumors (Furth-Columbia Wilms' tumor in Furth-Wistar rats, C-1300 neuroblastoma in A/J mice and HM-Kim mammary carcinoma in Wistar rats) but not in the NIH adenocarcinoma in Balb/c mice." | 3.68 | Studies on tumor induced angiogenesis. ( Ambrus, CM; Ambrus, JL; Forgach, P; Halpern, J; Niswander, P; Sayyid, S; Stadler, S; Toumbis, C, 1992) |
"Pentoxifylline (PTX) has been reported to have both direct and indirect anti-tumor effects in experimental tumor models." | 1.30 | The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma. ( Amirkhosravi, A; Biggerstaff, J; Francis, JL; Malik, Z; May, K; Warnes, G, 1997) |
Research
Studies (6)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 4 (66.67) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 2 (33.33) | 2.80 |
Authors
Authors | Studies |
---|---|
Janitschke, D | 2 |
Lauer, AA | 2 |
Bachmann, CM | 2 |
Winkler, J | 1 |
Griebsch, LV | 1 |
Pilz, SM | 1 |
Theiss, EL | 1 |
Grimm, HS | 2 |
Hartmann, T | 2 |
Grimm, MOW | 2 |
Seyfried, M | 1 |
Yang, KD | 2 |
Chuen, HL | 1 |
Shaio, MF | 2 |
Wang, CL | 1 |
Wu, NC | 1 |
Stone, RM | 1 |
Amirkhosravi, A | 1 |
Warnes, G | 1 |
Biggerstaff, J | 1 |
Malik, Z | 1 |
May, K | 1 |
Francis, JL | 1 |
Ambrus, JL | 1 |
Ambrus, CM | 1 |
Forgach, P | 1 |
Stadler, S | 1 |
Halpern, J | 1 |
Sayyid, S | 1 |
Niswander, P | 1 |
Toumbis, C | 1 |
Other Studies
6 other studies available for pentoxifylline and Neuroblastoma
Article | Year |
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Methylxanthines Induce a Change in the AD/Neurodegeneration-Linked Lipid Profile in Neuroblastoma Cells.
Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Cholesterol; Humans; Lipids; Neural Stem Cells; Neuro | 2022 |
Unique Role of Caffeine Compared to Other Methylxanthines (Theobromine, Theophylline, Pentoxifylline, Propentofylline) in Regulation of AD Relevant Genes in Neuroblastoma SH-SY5Y Wild Type Cells.
Topics: Alzheimer Disease; Caffeine; Cell Line, Tumor; Gene Expression Regulation; Genes, Essential; Humans; | 2020 |
Pentoxifylline augments but does not antagonize TNF alpha-mediated neuroblastoma cell differentiation: modulation of calcium mobilization but not cAMP.
Topics: Acetylcholine; Calcium; Calcium Channel Blockers; Cell Cycle; Cell Differentiation; Cyclic AMP; Down | 1995 |
Neuroblastoma cell-mediated leukocyte chemotaxis: lineage-specific differentiation of interleukin-8 expression.
Topics: Cell Communication; Cell Differentiation; Chemotaxis, Leukocyte; Dose-Response Relationship, Drug; E | 1994 |
The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma.
Topics: Animals; Carcinogenicity Tests; Cell Adhesion; Cell Cycle; Cell Division; Cell Membrane; Female; Fib | 1997 |
Studies on tumor induced angiogenesis.
Topics: Adenocarcinoma; Aminocaproic Acid; Animals; Cornea; Ditiocarb; Humans; Kidney Neoplasms; Macaca; Mam | 1992 |