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pd 98059 and Vasospasm, Intracranial

pd 98059 has been researched along with Vasospasm, Intracranial in 5 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).

Research Excerpts

ExcerptRelevanceReference
"Using a "two-hemorrhage" model of subarachnoid hemorrhage (SAH), this study investigated the function of ERK1/2 and vascular wall cell proliferation in pathological development of cerebral vasospasm."1.35Role of ERK1/2 and vascular cell proliferation in cerebral vasospasm after experimental subarachnoid hemorrhage. ( Chen, D; Chen, JJ; Guan, JH; Liu, YH; Yin, Q, 2009)
"Even though cerebral vasospasm after subarachnoid hemorrhage (SAH) causes cerebral ischemia or infarction, the metabolic alterations in cerebrospinal fluids (CSF) after SAH have not been studied."1.31Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs. ( Aoki, K; Badr, A; Tibbs, R; Yin, W; Zhang, J, 2002)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, D1
Chen, JJ1
Yin, Q1
Guan, JH1
Liu, YH1
Yin, W1
Tibbs, R2
Aoki, K4
Badr, A2
Zhang, J2
Zubkov, A1
Meguro, T1
Parent, A1
Zubkov, AY2
Tibbs, RE2
Zhang, JH2

Other Studies

5 other studies available for pd 98059 and Vasospasm, Intracranial

ArticleYear
Role of ERK1/2 and vascular cell proliferation in cerebral vasospasm after experimental subarachnoid hemorrhage.
    Acta neurochirurgica, 2009, Volume: 151, Issue:9

    Topics: Animals; Basilar Artery; Cell Proliferation; Disease Models, Animal; Enzyme Activation; Enzyme Inhib

2009
Metabolic alterations in cerebrospinal fluid from double hemorrhage model of dogs.
    Acta neurochirurgica. Supplement, 2002, Volume: 81

    Topics: Analysis of Variance; Animals; Caspase Inhibitors; Cerebral Hemorrhage; Disease Models, Animal; Dogs

2002
Effects of mitogen-activated protein kinase inhibitors on cerebral vasospasm in a double-hemorrhage model in dogs.
    Journal of neurosurgery, 2000, Volume: 93, Issue:6

    Topics: Animals; Butadienes; Cerebral Angiography; Cerebral Arteries; Disease Models, Animal; Dogs; Flavonoi

2000
Prevention of vasospasm in penetrating arteries with MAPK inhibitors in dog double-hemorrhage model.
    Surgical neurology, 2000, Volume: 54, Issue:3

    Topics: Animals; Basilar Artery; Butadienes; Cerebral Arteries; Dogs; Enzyme Inhibitors; Female; Flavonoids;

2000
Role of MAPK in chronic cerebral vasospasm.
    Life sciences, 2002, Mar-08, Volume: 70, Issue:16

    Topics: Animals; Blood Pressure; Chronic Disease; Dimethyl Sulfoxide; Dogs; Female; Flavonoids; Male; Mitoge

2002
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