pd 98059 and Endometriosis
pd 98059 has been researched along with Endometriosis in 7 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Endometriosis: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"To study the role of epidermal growth factor (EGF) , epidermal growth factor receptor(EGFR), extracellular signal-regulated kinase 1/2 (p-ERK1/2) in the pathogenesis of endometriosis under estrogen deprivation conditions." | 7.79 | [Role of epidermal growth factor signaling system in the pathogenesis of endometriosis under estrogen deprivation conditions]. ( Guo, RM; Sheng, W; Wang, YQ; Yin, LR, 2013) |
"Leptin acts as a potential growth stimulator in several normal and neoplastic cells." | 5.39 | Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways. ( Choi, JH; Choi, YS; Kim, JH; Leung, PC; Oh, HK; Yang, YI, 2013) |
"To study the role of epidermal growth factor (EGF) , epidermal growth factor receptor(EGFR), extracellular signal-regulated kinase 1/2 (p-ERK1/2) in the pathogenesis of endometriosis under estrogen deprivation conditions." | 3.79 | [Role of epidermal growth factor signaling system in the pathogenesis of endometriosis under estrogen deprivation conditions]. ( Guo, RM; Sheng, W; Wang, YQ; Yin, LR, 2013) |
"Endometriosis has been initially described as endometrial-like tissue outside of the uterine cavity." | 1.48 | USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway. ( Chen, Q; Hang, Y; Jin, Y; Li, S; Tan, L; Zhang, T, 2018) |
"Leptin acts as a potential growth stimulator in several normal and neoplastic cells." | 1.39 | Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways. ( Choi, JH; Choi, YS; Kim, JH; Leung, PC; Oh, HK; Yang, YI, 2013) |
"Endometriosis is an estrogen-dependent disease characterized by the presence of endometrial tissue outside of the uterine cavity, causing pelvic pain and infertility in 10% of reproductive-aged women." | 1.35 | Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis. ( Arici, A; Atabekoglu, CS; Cakmak, H; Ensari, A; Heper, A; Kayisli, UA; Murk, W, 2008) |
Research
Studies (7)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (28.57) | 29.6817 |
2010's | 5 (71.43) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Yu, XY | 1 |
Wang, XT | 1 |
Chu, YL | 1 |
Qu, HM | 1 |
Liu, J | 1 |
Zhang, YH | 1 |
Li, MJ | 1 |
Chen, Q | 1 |
Hang, Y | 1 |
Zhang, T | 1 |
Tan, L | 1 |
Li, S | 1 |
Jin, Y | 1 |
Wang, YQ | 1 |
Yin, LR | 1 |
Guo, RM | 1 |
Sheng, W | 1 |
Kim, JH | 2 |
Woo, JH | 1 |
Kim, HM | 1 |
Oh, MS | 1 |
Jang, DS | 1 |
Choi, JH | 2 |
Murk, W | 1 |
Atabekoglu, CS | 1 |
Cakmak, H | 1 |
Heper, A | 1 |
Ensari, A | 1 |
Kayisli, UA | 1 |
Arici, A | 1 |
Oh, HK | 1 |
Choi, YS | 1 |
Yang, YI | 1 |
Leung, PC | 1 |
Yoshino, O | 1 |
Osuga, Y | 1 |
Hirota, Y | 1 |
Koga, K | 1 |
Hirata, T | 1 |
Harada, M | 1 |
Morimoto, C | 1 |
Yano, T | 1 |
Nishii, O | 1 |
Tsutsumi, O | 1 |
Taketani, Y | 1 |
Other Studies
7 other studies available for pd 98059 and Endometriosis
Article | Year |
---|---|
Effect of FGF2 on the activity of SPRYs/DUSP6/ERK signaling pathway in endometrial glandular epithelial cells of endometriosis.
Topics: Antibodies, Neutralizing; Butadienes; Cell Line; Dual Specificity Phosphatase 6; Endometriosis; Endo | 2018 |
USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway.
Topics: Apoptosis; Cell Movement; Cell Proliferation; Endometriosis; Endometrium; Epithelial Cells; Female; | 2018 |
[Role of epidermal growth factor signaling system in the pathogenesis of endometriosis under estrogen deprivation conditions].
Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endometriosis; Endometrium; Ep | 2013 |
Anti-Endometriotic Effects of Pueraria Flower Extract in Human Endometriotic Cells and Mice.
Topics: Animals; Cell Adhesion; Cell Line; Cell Movement; Cell Survival; Down-Regulation; Endometriosis; End | 2017 |
Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis.
Topics: Cell Survival; Cells, Cultured; Endometriosis; Endometrium; Enzyme Inhibitors; Estradiol; Extracellu | 2008 |
Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways.
Topics: Adult; Cell Proliferation; Cells, Cultured; Endometriosis; Endometrium; Enzyme Inhibitors; Epithelia | 2013 |
Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis.
Topics: Anthracenes; Cells, Cultured; Cyclooxygenase 2; Endometriosis; Endometrium; Enzyme Inhibitors; Extra | 2004 |