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pd 98059 and Endometriosis

pd 98059 has been researched along with Endometriosis in 7 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Endometriosis: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.

Research Excerpts

ExcerptRelevanceReference
"To study the role of epidermal growth factor (EGF) , epidermal growth factor receptor(EGFR), extracellular signal-regulated kinase 1/2 (p-ERK1/2) in the pathogenesis of endometriosis under estrogen deprivation conditions."7.79[Role of epidermal growth factor signaling system in the pathogenesis of endometriosis under estrogen deprivation conditions]. ( Guo, RM; Sheng, W; Wang, YQ; Yin, LR, 2013)
"Leptin acts as a potential growth stimulator in several normal and neoplastic cells."5.39Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways. ( Choi, JH; Choi, YS; Kim, JH; Leung, PC; Oh, HK; Yang, YI, 2013)
"To study the role of epidermal growth factor (EGF) , epidermal growth factor receptor(EGFR), extracellular signal-regulated kinase 1/2 (p-ERK1/2) in the pathogenesis of endometriosis under estrogen deprivation conditions."3.79[Role of epidermal growth factor signaling system in the pathogenesis of endometriosis under estrogen deprivation conditions]. ( Guo, RM; Sheng, W; Wang, YQ; Yin, LR, 2013)
"Endometriosis has been initially described as endometrial-like tissue outside of the uterine cavity."1.48USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway. ( Chen, Q; Hang, Y; Jin, Y; Li, S; Tan, L; Zhang, T, 2018)
"Leptin acts as a potential growth stimulator in several normal and neoplastic cells."1.39Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways. ( Choi, JH; Choi, YS; Kim, JH; Leung, PC; Oh, HK; Yang, YI, 2013)
"Endometriosis is an estrogen-dependent disease characterized by the presence of endometrial tissue outside of the uterine cavity, causing pelvic pain and infertility in 10% of reproductive-aged women."1.35Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis. ( Arici, A; Atabekoglu, CS; Cakmak, H; Ensari, A; Heper, A; Kayisli, UA; Murk, W, 2008)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yu, XY1
Wang, XT1
Chu, YL1
Qu, HM1
Liu, J1
Zhang, YH1
Li, MJ1
Chen, Q1
Hang, Y1
Zhang, T1
Tan, L1
Li, S1
Jin, Y1
Wang, YQ1
Yin, LR1
Guo, RM1
Sheng, W1
Kim, JH2
Woo, JH1
Kim, HM1
Oh, MS1
Jang, DS1
Choi, JH2
Murk, W1
Atabekoglu, CS1
Cakmak, H1
Heper, A1
Ensari, A1
Kayisli, UA1
Arici, A1
Oh, HK1
Choi, YS1
Yang, YI1
Leung, PC1
Yoshino, O1
Osuga, Y1
Hirota, Y1
Koga, K1
Hirata, T1
Harada, M1
Morimoto, C1
Yano, T1
Nishii, O1
Tsutsumi, O1
Taketani, Y1

Other Studies

7 other studies available for pd 98059 and Endometriosis

ArticleYear
Effect of FGF2 on the activity of SPRYs/DUSP6/ERK signaling pathway in endometrial glandular epithelial cells of endometriosis.
    European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:6

    Topics: Antibodies, Neutralizing; Butadienes; Cell Line; Dual Specificity Phosphatase 6; Endometriosis; Endo

2018
USP10 promotes proliferation and migration and inhibits apoptosis of endometrial stromal cells in endometriosis through activating the Raf-1/MEK/ERK pathway.
    American journal of physiology. Cell physiology, 2018, 12-01, Volume: 315, Issue:6

    Topics: Apoptosis; Cell Movement; Cell Proliferation; Endometriosis; Endometrium; Epithelial Cells; Female;

2018
[Role of epidermal growth factor signaling system in the pathogenesis of endometriosis under estrogen deprivation conditions].
    Zhonghua fu chan ke za zhi, 2013, Volume: 48, Issue:6

    Topics: Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Endometriosis; Endometrium; Ep

2013
Anti-Endometriotic Effects of Pueraria Flower Extract  in Human Endometriotic Cells and Mice.
    Nutrients, 2017, Feb-28, Volume: 9, Issue:3

    Topics: Animals; Cell Adhesion; Cell Line; Cell Movement; Cell Survival; Down-Regulation; Endometriosis; End

2017
Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis.
    The Journal of clinical endocrinology and metabolism, 2008, Volume: 93, Issue:9

    Topics: Cell Survival; Cells, Cultured; Endometriosis; Endometrium; Enzyme Inhibitors; Estradiol; Extracellu

2008
Leptin receptor is induced in endometriosis and leptin stimulates the growth of endometriotic epithelial cells through the JAK2/STAT3 and ERK pathways.
    Molecular human reproduction, 2013, Volume: 19, Issue:3

    Topics: Adult; Cell Proliferation; Cells, Cultured; Endometriosis; Endometrium; Enzyme Inhibitors; Epithelia

2013
Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2004, Volume: 52, Issue:5

    Topics: Anthracenes; Cells, Cultured; Cyclooxygenase 2; Endometriosis; Endometrium; Enzyme Inhibitors; Extra

2004
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