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papaverine and Epilepsy

papaverine has been researched along with Epilepsy in 12 studies

Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"Papaverine is a vasodilator agent that is an opium alkaloid."1.48Proconvulsant Effect of Papaverine on Penicillin-Induced Epileptiform Activity in Rats. ( Cokluk, C; Him, A; Kocacan, SE; Kuruoglu, E; Marangoz, AH; Marangoz, C, 2018)
"The grave course of epilepsy is associated with a decrease of the LCBF on the side of the focus."1.28[Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy]. ( Shestakov, VV; Shutov, AA, 1990)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-199010 (83.33)18.7374
1990's1 (8.33)18.2507
2000's0 (0.00)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Marangoz, AH1
Kocacan, SE1
Him, A1
Kuruoglu, E1
Cokluk, C1
Marangoz, C1
SEREISKII, MIa1
USPENSKAIA, MA1
WIRTH, L1
MEYER, JS1
ISHIKAWA, S1
LEE, TK1
MERCIER, J1
RUSSEK, HL1
ZOHMAN, BL1
Shutov, AA2
Pleshkova, NM1
Shestakov, VV2
Pozdniakov, VS1
Vailly, B1
Rougeron, G1
Weill, A1
Bollack, C1
Hadjiev, D1

Reviews

1 review available for papaverine and Epilepsy

ArticleYear
Impedance methods for investigation of cerebral circulation.
    Progress in brain research, 1972, Volume: 35

    Topics: Adenosine Triphosphate; Animals; Brain Neoplasms; Carbon Dioxide; Carotid Artery Diseases; Cerebral

1972

Other Studies

11 other studies available for papaverine and Epilepsy

ArticleYear
Proconvulsant Effect of Papaverine on Penicillin-Induced Epileptiform Activity in Rats.
    Turkish neurosurgery, 2018, Volume: 28, Issue:3

    Topics: Animals; Convulsants; Epilepsy; Female; Papaverine; Penicillins; Rats; Rats, Wistar; Seizures; Vasod

2018
[New method of therapy of epilepsy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1955, Volume: 55, Issue:9

    Topics: Barbiturates; Bromides; Epilepsy; Humans; Hypnotics and Sedatives; Papaverine

1955
[Result of the treatment of epilepsy in children with Sereiskii's mixture].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1955, Volume: 55, Issue:9

    Topics: Barbiturates; Bromides; Child; Epilepsy; Humans; Hypnotics and Sedatives; Papaverine

1955
Papaverine hydrochloride in status epilepticus.
    Military medicine, 1956, Volume: 118, Issue:5

    Topics: Epilepsy; Humans; Papaverine; Status Epilepticus

1956
ELECTROMAGNETIC MEASUREMENT OF INTERNAL JUGULAR VENOUS FLOW IN THE MONKEY; EFFECT OF EPILEPSY AND OTHER PROCEDURES.
    Journal of neurosurgery, 1964, Volume: 21

    Topics: Anesthesia; Animals; Apnea; Bemegride; Blood Flow Velocity; Carbon Dioxide; Cerebrovascular Circulat

1964
[Effect on audiogenic seizure of white rat of some natural or synthetic alkaloids derived from opium: morphine, dihydro-oxycodeinone, papaverine].
    Journal de physiologie, 1950, Volume: 42, Issue:3

    Topics: Alkaloids; Animals; Epilepsy; Epilepsy, Reflex; Morphine; Opium; Papaverine; Rats; Seizures

1950
Papaverine in epilepsy.
    New York state journal of medicine, 1949, Jun-01, Volume: 49, Issue:11

    Topics: Epilepsy; Humans; Papaverine

1949
[Disorders of cerebral hemodynamics and their correction in epilepsy].
    Sovetskaia meditsina, 1979, Issue:7

    Topics: Brain Ischemia; Caffeine; Cerebrovascular Circulation; Epilepsy; Humans; Papaverine; Phenobarbital

1979
[An analysis of 22 years' experience with the medicinal treatment of epilepsy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1975, Volume: 75, Issue:3

    Topics: Adult; Anticonvulsants; Bromides; Caffeine; Codeine; Drug Therapy, Combination; Epilepsy; Female; Hi

1975
[Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1990, Volume: 90, Issue:6

    Topics: Adolescent; Adult; Brain Ischemia; Caffeine; Cerebrovascular Circulation; Drug Therapy, Combination;

1990
[Epilepsy and hypertensive crisis after intracavernous injection of metaraminol in the treatment of priapism secondary to a papaverine test].
    Presse medicale (Paris, France : 1983), 1989, May-20, Volume: 18, Issue:20

    Topics: Epilepsy; Humans; Hypertension; Male; Metaraminol; Middle Aged; Papaverine; Priapism

1989