Page last updated: 2024-11-02

oxybutynin and Aging

oxybutynin has been researched along with Aging in 13 studies

oxybutynin: RN given refers to parent cpd
oxybutynin : A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" The search terms were overactive bladder, urinary incontinence, trospium, randomized controlled clinical trial, oxybutynin, tolterodine, scopolamine, imipramine, desipramine, and propantheline."4.82Trospium chloride for the treatment of overactive bladder with urge incontinence. ( Machado, C; Singh-Franco, D; Tuteja, S; Zapantis, A, 2005)
"To evaluate cognitive effects during chronic stable dosing with solifenacin and oxybutynin versus placebo in older (≥75 yr) subjects with MCI."2.78Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study. ( Compion, G; Dale, M; Stow, B; Tretter, R; Wagg, A, 2013)
" Pharmacokinetic parameters were determined for buprenorphine and norbuprenorphine."2.78Pharmacokinetics of transdermal buprenorphine patch in the elderly. ( Al-Tawil, N; Berggren, AC; Johnson, HE; Odar-Cederlöf, I; Persson, J, 2013)
"Darifenacin has a strong affinity for the M3 receptor in the bladder, while having a weak affinity for the M1 receptor commonly found in the brain."2.52Treatment of Overactive Bladder in the Elderly Female: The Case for Trospium, Oxybutynin, Fesoterodine and Darifenacin. ( Gomelsky, A; McFerren, SC, 2015)
" The results of the study argue against the dosage regimen proposed before these adverse events were detected."1.29Plasma levels of oxybutynine chloride in children. ( Autret, E; Averous, M; Bertiere, MC; Couet, W; Dutertre, JP; Jonville, AP; Robert, M, 1994)
" Pharmacokinetic parameters were obtained after a single oral dose of OB and after administration two or three times daily to frail elderly and elderly volunteer groups respectively."1.28Measurement of oxybutynin and its N-desethyl metabolite in plasma, and its application to pharmacokinetic studies in young, elderly and frail elderly volunteers. ( Geraint, M; Gordon, D; Hughes, KM; Lang, JC; Lazare, R; Malone-Lee, J; Stanton, SL, 1992)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.69)18.7374
1990's3 (23.08)18.2507
2000's1 (7.69)29.6817
2010's7 (53.85)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Wagg, A2
Dale, M2
Tretter, R2
Stow, B2
Compion, G2
McFerren, SC1
Gomelsky, A1
Cornu, JN1
Singh-Franco, D1
Machado, C1
Tuteja, S1
Zapantis, A1
Saito, M1
Yamada, A1
Miyazaki, Y1
Sakurada, T1
Kisara, K1
Autret, E1
Jonville, AP1
Dutertre, JP1
Bertiere, MC1
Robert, M1
Averous, M1
Couet, W1
Hughes, KM1
Lang, JC1
Lazare, R1
Gordon, D1
Stanton, SL1
Malone-Lee, J1
Geraint, M1
Vassilieva, EV1
Li, S1
Korniychuk, H1
Taylor, DM1
Wang, S1
Prausnitz, MR1
Compans, RW1
Luchting, B1
Azad, SC1
Al-Tawil, N1
Odar-Cederlöf, I1
Berggren, AC1
Johnson, HE1
Persson, J1
Konda, S1
Meier-Davis, SR1
Cayme, B1
Shudo, J1
Maibach, HI1
CANOVA, F2
FABRIS, F2

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double Blind, Randomized Four Way Cross Over Study to Compare the Effect of Fesoterodine 4mg and 8mg Once Daily and Oxybutynin 5mg Twice Daily After Steady State Dosing Versus Placebo on Cognitive Function in Subjects With Overactive Bladder, Over the A[NCT02240459]Phase 247 participants (Actual)Interventional2016-08-31Completed
A Study to Compare the Cognitive Effect of Solifenacin 5mg Once-daily and Oxybutynin 5mg Twice-daily After Chronic Dosing Versus Placebo in Subjects 75 Years and Over With Mild Cognitive Impairment - A Double-blind, Randomized, Multi-center Study[NCT01126424]Phase 426 participants (Actual)Interventional2010-04-30Completed
Randomized Cross-Over Study of Fesoterodine on Urgency Episodes in Parkinson's Disease Population[NCT02385500]Phase 45 participants (Actual)Interventional2016-09-30Terminated (stopped due to Insufficient or untimely patient recruitment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in Cognitive Function Composite Score - Continuity of Attention

Cognitive effects were assessed using a computerized assessment system at time points close to the predicted time of maximum plasma concentration for solifenacin and oxybutynin. For continuity of attention, the number of correct responses (out of 50) for choice reaction time was added to the total number of targets correctly identified (out of 45) digit vigilance minus the number of false alarms (total score of -45 to 95). A high score reflects someone able to keep his/her mind on a single task for a prolonged period. A negative change from baseline reflects impairment compared to baseline. (NCT01126424)
Timeframe: Assessed at each treatment period baseline visit (the day prior to the first dose of each treatment; Days -1, 42, 84) and at the end of each treatment period (Days 21, 63 and 105). At each visit, tests were performed at 2 and 6 hours post-dose.

,,
InterventionScores on a scale (Mean)
Baseline at 2 hours [Oxybutynin Tmax]Change from Baseline at 2 hoursBaseline at 6 hours [Solifenacin Tmax]Change from Baseline at 6 hours
Oxybutynin91.3000.15091.9010.100
Placebo91.3640.90991.728-0.045
Solifenacin91.5910.54591.228-0.318

Change From Baseline in Cognitive Function Composite Score - Power of Attention

Cognitive effects were assessed at the end of each treatment period using a computerized assessment system at time points close to the predicted time to attain maximum plasma concentration (Tmax) for solifenacin (6 hours) and oxybutynin (2 hours). Power of attention is calculated from the sum of three cognitive function speed tests: Simple Reaction Time, Choice Reaction Time and the Speed of Detections in Digit Vigilance task. A low score reflects a fast reaction time and a high intensity of concentration. A positive change from baseline reflects impairment compared to the baseline assessment. (NCT01126424)
Timeframe: Assessed at each treatment period baseline visit (the day prior to the first dose of each treatment; Days -1, 42, 84) and at the end of each treatment period (Days 21, 63 and 105). At each visit, tests were performed at 2 and 6 hours post-dose.

,,
Interventionmsec (Mean)
Baseline at 2 hours [Oxybutynin Tmax]Change from Baseline at 2 hoursBaseline at 6 hours [Solifenacin Tmax]Change from Baseline at 6 hours
Oxybutynin1423.3817.811405.41-0.74
Placebo1401.211.991393.9811.77
Solifenacin1413.67-5.861421.80-14.80

Change From Baseline in Cognitive Function Composite Score - Quality of Episodic Secondary Memory

Cognitive effects were assessed at the end of each treatment period using a computerized assessment system at time points close to the predicted time of maximum plasma concentration for solifenacin and oxybutynin. Quality of episodic secondary memory is calculated from the sum of 4 tests: Immediate and delayed word recall, and word and picture recognition, and ranges from -200 to 400. A high score reflects a good ability to store, hold and retrieve information of an episodic nature (i.e. an event or a name) and a negative change from baseline reflects impairment compared to baseline. (NCT01126424)
Timeframe: Assessed at each treatment period baseline visit (the day prior to the first dose of each treatment; Days -1, 42, 84) and at the end of each treatment period (Days 21, 63 and 105). At each visit, tests were performed at 2 and 6 hours post-dose.

,,
InterventionScores on a scale (Mean)
Baseline at 2 hours [Oxybutynin Tmax]Change from Baseline at 2 hoursBaseline at 6 hours [Solifenacin Tmax]Change from Baseline at 6 hours
Oxybutynin107.666333-0.917833104.917167-3.502000
Placebo110.0001520.531515106.5150001.589394
Solifenacin111.893636-3.788636101.3634857.728182

Change From Baseline in Cognitive Function Composite Score - Quality of Working Memory

Cognitive effects were assessed at the end of each treatment period using a computerized assessment system at time points close to the predicted time to attain maximum plasma concentration (Tmax) for solifenacin (6 hours) and oxybutynin (2 hours). Quality of working memory is calculated from the sum of two cognitive function sensitivity tests: Numeric Working Memory Sensitivity and Spatial Working Memory Sensitivity, and ranges from -2 to 2. A higher score reflects a good working memory and a negative change from baseline reflects impairment compared to the baseline assessment. (NCT01126424)
Timeframe: Assessed at each treatment period baseline visit (the day prior to the first dose of each treatment; Days -1, 42, 84) and at the end of each treatment period (Days 21, 63 and 105). At each visit, tests were performed at 2 and 6 hours post-dose.

,,
InterventionScores on a scale (Mean)
Baseline at 2 hours [Oxybutynin Tmax]Change from Baseline at 2 hoursBaseline at 6 hours [Solifenacin Tmax]Change from Baseline at 6 hours
Oxybutynin1.7251-0.00431.64410.0633
Placebo1.70870.04921.75480.0047
Solifenacin1.7921-0.08671.66660.0580

Change From Baseline in Cognitive Function Composite Score - Speed of Memory

Cognitive effects were assessed at the end of each treatment period using a computerized assessment system at time points close to the predicted time to attain maximum plasma concentration for solifenacin and oxybutynin. Speed of Memory was calculated from the sum of 4 cognitive function speed tests: numeric and spatial working memory and word and picture recognition. A low score reflects that a person is able to recall a name, a face or any other item fast from the episodic secondary memory; a positive change from baseline reflects impairment compared to baseline. (NCT01126424)
Timeframe: Assessed at each treatment period baseline visit (the day prior to the first dose of each treatment; Days -1, 42, 84) and at the end of each treatment period (Days 21, 63 and 105). At each visit, tests were performed at 2 and 6 hours post-dose.

,,
Interventionmsec (Mean)
Baseline at 2 hours [Oxybutynin Tmax]Change from Baseline at 2 hoursBaseline at 6 hours [Solifenacin Tmax]Change from Baseline at 6 hours
Oxybutynin4545.75-11.564606.51-118.14
Placebo4741.30-240.624655.29-126.04
Solifenacin4505.9624.094496.65-149.79

Change From Baseline in Postural Stability Test

"The postural stability test measures the ability to stand upright without moving, and was assessed at the end of each treatment period using a computerized assessment system at time points close to the predicted time to attain maximum plasma concentration for solifenacin and oxybutynin. Using apparatus modeled on the Wright Ataxia-meter, a cord from the meter is attached to the patient who is required to stand as still as possible with feet apart and eyes closed for 1 minute.~The amount of sway is expressed as the total angular movement, summed regardless of sign, in the antero-posterior plane and calibrated in units of one-third degree of angle of sway. Wright (1971) described a range of 20-30 units as a normal range for adults with eyes wide open, increasing by 50 to 100% with eyes shut." (NCT01126424)
Timeframe: Assessed at each treatment period baseline visit (the day prior to the first dose of each treatment; Days -1, 42, 84) and at the end of each treatment period (Days 21, 63 and 105). At each visit, tests were performed at 2 and 6 hours post-dose.

,,
Intervention1/3 degree of angle of sway (Mean)
Baseline at 2 hours [Oxybutynin Tmax]Change from Baseline at 2 hoursBaseline at 6 hours [Solifenacin Tmax]Change from Baseline at 6 hours
Oxybutynin36.22.738.90.7
Placebo37.50.440.0-0.1
Solifenacin37.75.237.79.9

Reviews

3 reviews available for oxybutynin and Aging

ArticleYear
Treatment of Overactive Bladder in the Elderly Female: The Case for Trospium, Oxybutynin, Fesoterodine and Darifenacin.
    Drugs & aging, 2015, Volume: 32, Issue:10

    Topics: Aged; Aging; Benzhydryl Compounds; Benzofurans; Blood-Brain Barrier; Cognition; Female; Humans; Mand

2015
Trospium chloride for the treatment of overactive bladder with urge incontinence.
    Clinical therapeutics, 2005, Volume: 27, Issue:5

    Topics: Aging; Area Under Curve; Benzhydryl Compounds; Benzilates; Cholinergic Antagonists; Cresols; Female;

2005
Pain therapy for the elderly patient: is opioid-free an option?
    Current opinion in anaesthesiology, 2019, Volume: 32, Issue:1

    Topics: Administration, Topical; Age Factors; Aged; Aging; Analgesics, Non-Narcotic; Analgesics, Opioid; Cap

2019

Trials

2 trials available for oxybutynin and Aging

ArticleYear
Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study.
    European urology, 2013, Volume: 64, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Attention; Cognition; Cognitive D

2013
Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study.
    European urology, 2013, Volume: 64, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Attention; Cognition; Cognitive D

2013
Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study.
    European urology, 2013, Volume: 64, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Attention; Cognition; Cognitive D

2013
Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study.
    European urology, 2013, Volume: 64, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Attention; Cognition; Cognitive D

2013
Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study.
    European urology, 2013, Volume: 64, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Attention; Cognition; Cognitive D

2013
Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study.
    European urology, 2013, Volume: 64, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Attention; Cognition; Cognitive D

2013
Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study.
    European urology, 2013, Volume: 64, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Attention; Cognition; Cognitive D

2013
Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study.
    European urology, 2013, Volume: 64, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Attention; Cognition; Cognitive D

2013
Randomised, multicentre, placebo-controlled, double-blind crossover study investigating the effect of solifenacin and oxybutynin in elderly people with mild cognitive impairment: the SENIOR study.
    European urology, 2013, Volume: 64, Issue:1

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Analysis of Variance; Attention; Cognition; Cognitive D

2013
Pharmacokinetics of transdermal buprenorphine patch in the elderly.
    European journal of clinical pharmacology, 2013, Volume: 69, Issue:2

    Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Area Under Curve; Bup

2013

Other Studies

8 other studies available for oxybutynin and Aging

ArticleYear
Reply from authors re: Jean-Nicolas Cornu. Overactive bladder medical management in the elderly: it is time to go beyond the tip of the iceberg. Eur Urol 2013;64:82-3.
    European urology, 2013, Volume: 64, Issue:1

    Topics: Aging; Cognition; Cognitive Dysfunction; Female; Humans; Male; Mandelic Acids; Muscarinic Antagonist

2013
Overactive bladder medical management in the elderly: it is time to go beyond the tip of the iceberg.
    European urology, 2013, Volume: 64, Issue:1

    Topics: Aging; Cognition; Cognitive Dysfunction; Female; Humans; Male; Mandelic Acids; Muscarinic Antagonist

2013
Histological study of the parotid gland in rats treated with oxybutynin hydrochloride.
    Research communications in molecular pathology and pharmacology, 1994, Volume: 85, Issue:3

    Topics: Aging; Animals; Diet; Male; Mandelic Acids; Parasympatholytics; Parotid Gland; Rats; Rats, Wistar

1994
Plasma levels of oxybutynine chloride in children.
    European journal of clinical pharmacology, 1994, Volume: 46, Issue:1

    Topics: Adolescent; Aging; Body Weight; Child; Child, Preschool; Female; Humans; Male; Mandelic Acids; Paras

1994
Measurement of oxybutynin and its N-desethyl metabolite in plasma, and its application to pharmacokinetic studies in young, elderly and frail elderly volunteers.
    Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:7

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Aging; Biological Availability; Chromatography

1992
cGAMP/Saponin Adjuvant Combination Improves Protective Response to Influenza Vaccination by Microneedle Patch in an Aged Mouse Model.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Adjuvants, Immunologic; Aging; Animals; Disease Models, Animal; Drug Delivery Systems; Female; Human

2020
Age-related percutaneous penetration part 2: effect of age on dermatopharmacokinetics and overview of transdermal products.
    Skin therapy letter, 2012, Volume: 17, Issue:6

    Topics: Administration, Cutaneous; Age Factors; Aged; Aging; Drug Delivery Systems; Humans; Permeability; Ph

2012
[Tuberculin patch reaction in various ages].
    Minerva medica, 1956, Aug-18, Volume: 47, Issue:65-66

    Topics: Aging; Glycation End Products, Advanced; Humans; Transdermal Patch; Tuberculin; Tuberculin Test

1956
[Tuberculin patch reaction in various ages].
    Minerva medica, 1956, Aug-18, Volume: 47, Issue:65-66

    Topics: Aging; Glycation End Products, Advanced; Humans; Transdermal Patch; Tuberculin; Tuberculin Test

1956
[Tuberculin patch reaction in various ages].
    Minerva medica, 1956, Aug-18, Volume: 47, Issue:65-66

    Topics: Aging; Glycation End Products, Advanced; Humans; Transdermal Patch; Tuberculin; Tuberculin Test

1956
[Tuberculin patch reaction in various ages].
    Minerva medica, 1956, Aug-18, Volume: 47, Issue:65-66

    Topics: Aging; Glycation End Products, Advanced; Humans; Transdermal Patch; Tuberculin; Tuberculin Test

1956