Page last updated: 2024-11-01

ns 1619 and Cough

ns 1619 has been researched along with Cough in 2 studies

NS 1619: structure given in first source
NS 1619 : A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"In this study we investigated whether openers of potassium channels, K+ATP--pinacidil and BK+Ca--NS1619, modulate cough reflex and airway smooth muscle (ASM) reactivity in in vivo and in vitro conditions in guinea pigs."3.74The role of potassium ion channels in cough and other reflexes of the airways. ( Franova, S; Nosalova, G; Sutovska, M, 2007)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sutovska, M1
Nosalova, G1
Franova, S1
Fox, AJ1
Barnes, PJ1
Venkatesan, P1
Belvisi, MG1

Other Studies

2 other studies available for ns 1619 and Cough

ArticleYear
The role of potassium ion channels in cough and other reflexes of the airways.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2007, Volume: 58 Suppl 5, Issue:Pt 2

    Topics: Acetylcholine; Aerosols; Airway Resistance; Animals; Benzimidazoles; Citric Acid; Cough; Glyburide;

2007
Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig.
    The Journal of clinical investigation, 1997, Feb-01, Volume: 99, Issue:3

    Topics: Afferent Pathways; Animals; Benzimidazoles; Bradykinin; Bronchi; Bronchial Provocation Tests; Citric

1997