nitroglycerin and Pain studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

Excerpt	Relevance	Reference
"The aim of this study was to determine the optimal dose and dosing interval of nitroglycerin ointment to heal chronic anal fissures."	10.20	A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures. ( Bailey, HR; Beck, DE; Billingham, RP; Binderow, SR; Gibbons, RD; Gottesman, L; Hull, TL; Larach, SW; Margolin, DA; Milsom, JW; Potenti, FM; Rafferty, JF; Riff, DS; Sands, LR; Senagore, A; Stamos, MJ; Yee, LF; Young-Fadok, TM, 2002)
" To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application."	9.17	Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013)
"A significantly higher proportion of patients in the placebo group (83 %) experienced pain compared to the lidocaine and combination groups (43 and 7 %, respectively; both, P < 0."	9.16	Reduction of pain on injection of propofol: combination of nitroglycerin and lidocaine. ( Jeon, Y, 2012)
"According to our study, there was no benefit regarding healing or pain relief, in treating patients suffering from an anal fissure with Nitroglycerin ointment in combination with stool softeners and sitz baths, compared to the same treatment without Nitroglycerin ointment."	9.11	[A prospective, randomized double-blind study on the treatment of anal fissures with Nitroglycerin ointment]. ( Gelertner, I; Halevy, A; Levy, N; Negri, M; Weinstein, D; Ziv, Y, 2004)
" Nimesulide is a preferential COX-2 inhibitor widely used to treat pain."	9.10	Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2003)
"To examine analgesia and adverse effects following transdermal application of nitroglycerine (a nitric oxide generator) combined with oral morphine, in cancer pain patients."	9.10	Double-blind evaluation of transdermal nitroglycerine as adjuvant to oral morphine for cancer pain management. ( Lauretti, GR; Pereira, NL; Perez, MV; Reis, MP, 2002)
" Nitroglycerin (NTG) administration commonly causes a headache with some features similar to those of a migraine."	9.09	The pharmacodynamics of sumatriptan in nitroglycerin-induced headache. ( Forrest, A; Fullerton, T; Gengo, FM; Komorowski-Swiatek, D, 1999)
"We have conducted a prospective double blind randomized and placebo controlled clinical study in 20 patients with shoulder pain syndrome caused by supraspinatus tendinitis to determine whether transdermal nitroglycerin (NTG) has analgesic action in this condition."	9.08	Successful treatment of shoulder pain syndrome due to supraspinatus tendinitis with transdermal nitroglycerin. A double blind study. ( Amado, JA; Berrazueta, JR; Losada, A; Ochoteco, A; Poveda, J; Riestra, A; Salas, E, 1996)
"Nitroglycerin (glyceryl trinitrate, CAS 55-63-0, NTG) administered with an oral spray may be more effective in relieving anginal pain than sublingual tablets especially when the patient's mouth is dry."	9.08	Studies on the response of nitroglycerin oral spray compared with sublingual tablets for angina pectoris patients with dry mouth. A multicenter trial. ( Fukui, S; Hori, M; Karita, M; Koretsune, Y; Matsuyama, T; Sato, H; Shimazu, T; Sugii, M; Taniguchi, T, 1997)
") lidocaine and topical nitroglycerin ointment in preventing pain during propofol injection."	9.08	Effects of topical nitroglycerin and intravenous lidocaine on propofol-induced pain on injection. ( Beven, M; Carpenter, T; Laseter, JT; Mascha, E; Maurer, WG; O'Hara, JR; Sprung, J, 1997)
" Our aim was to evaluate the feasibility of a pain-scoring method and to compare the response to sublingual administration of an isosorbide dinitrate (ISDN) tablet, ISDN spray or nitroglycerin (NTG) spray."	9.08	Pain scoring--a method for assessing acute antianginal therapy comparison of the response to acute sublingual administration of an isosorbide dinitrate tablet, isosorbide dinitrate spray and nitroglycerin spray in unstable angina. ( Brill, Z; Feigenberger, Z; Hod, H; Kaplinsky, E; Matetzky, S; Shachar, A; Shotan, A, 1998)
"To determine whether pain or discomfort could be provoked by adenosine in skeletal muscle and, if so, whether it was dependent on the vasodilatation produced by adenosine, eight male volunteers were given intra-arterial bolus injections of adenosine and glyceryl trinitrate into the forearm."	9.06	Adenosine injection into the brachial artery produces ischaemia like pain or discomfort in the forearm. ( Fredholm, BB; Jonzon, B; Kaijser, L; Sylvén, C, 1988)
"To assess the effects of verapamil and nifedipine on left ventricular function at rest and during exercise in patients with Prinzmetal's variant angina pectoris, 10 patients (6 men and 4 women with a mean age of 52 years) with variant angina were each treated for 2 months periods with placebo, verapamil (400 +/- 80 mg/day, mean +/- standard deviation [SD]) and nifedipine (82 +/- 31 mg/day)."	9.05	Effect of verapamil and nifedipine on left ventricular function at rest and during exercise in patients with Prinzmetal's variant angina pectoris. ( Corbett, J; Dehmer, GJ; Hillis, LD; Johnson, SM; Lewis, SE; Mauritson, DR; Willerson, JT, 1981)
"4% Nitroglycerin ointment is an intra-anal formulation of nitroglycerin (glyceryl trinitrate) indicated for the treatment of chronic anal fissure pain."	8.83	0.4% nitroglycerin ointment : in the treatment of chronic anal fissure pain. ( Easthope, SE; Fenton, C; Wellington, K, 2006)
"Nitroglycerin (NTG)-induced headache is the most common side effect of nitrate therapy and negatively affects the quality of life."	8.31	The effect of local cold compresses for nitroglycerin-induced headache: An observational pretest-posttest study. ( Enç, N; Uğurlu, YK, 2023)
" Treatment with GLP-1R agonist liraglutide attenuated trigeminal allodynia and suppressed the protein levels of CM-associated molecules in the trigeminal nucleus caudalis (TNC)."	8.31	GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model. ( Jing, F; Pu, Y; Zou, Q, 2023)
"This study aimed to investigate the antimigraine potential of quercetin in migraine pain induced by nitroglycerin (NTG), 10 mg/kg, intraperitoneal injection in rats."	8.12	Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. ( Alam, A; Almalki, HS; Alqarni, MH; Devi, S; Foudah, AI; Kumar, M; Salkini, MA, 2022)
"Calcitonin gene-related peptide (CGRP) and substance P (SP) play an important role in the development of pain and hyperalgesia."	7.74	Role of calcitonin gene-related peptide and substance P in different models of pain. ( Buscone, S; Di Bella, P; Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2008)
" The aim of the study was to investigate the additive effects of nitroglycerine combined with lornoxicam for acute pain in rats."	7.73	[The effects of combination of two lornoxicam doses and nitroglycerine on acute pain in rats]. ( Aydin, ON; Dost, T; Gürsoy, F; Oğurlu, M; Sen, S; Temuçin, S, 2005)
" We have investigated the central processing of cluster headache (CH) attacks provoked by sublingual nitroglycerin (NTG)."	7.69	Right-lateralised central processing for pain of nitroglycerin-induced cluster headache. ( Hannerz, J; Hsieh, JC; Ingvar, M, 1996)
"Eight patients with episodic cluster headache, five in active episode, three out of episode, were investigated as to diameters of intracranial arteries before and after nitroglycerin (NG) administration."	7.68	MRI of intracranial arteries in nitroglycerin induced cluster headache attacks. ( Greitz, D; Hannerz, J, 1992)
"No patient had a headache or experienced postural hypotension."	6.67	Pain on injection of propofol: modification by nitroglycerin. ( Anderson, M; Gauntlett, IS; Wilkinson, D, 1993)
"Nitroglycerin (NTG) has the potential to reduce myocardial ischemia during percutaneous transluminal coronary angioplasty (PTCA)."	6.67	Buccal nitroglycerin decreases ischemic pain during coronary angioplasty: a double-blind, randomized, placebo-controlled study. ( Ekström, L; Emanuelsson, H; Johansson, SR, 1990)
"Lidoflazine is a synthetic drug with calcium-channel blocking effects."	6.65	The effects of lidoflazine on exercise performance and thallium stress scintigraphy in patients with stable angina pectoris. ( Narahara, KA; Park, J; Shapiro, W, 1982)
"Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models."	6.61	Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. ( Borsook, D; De Icco, R; Demartini, C; Greco, R; Sances, G; Tassorelli, C; Zanaboni, AM, 2019)
"The aim of this study was to determine the optimal dose and dosing interval of nitroglycerin ointment to heal chronic anal fissures."	6.20	A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures. ( Bailey, HR; Beck, DE; Billingham, RP; Binderow, SR; Gibbons, RD; Gottesman, L; Hull, TL; Larach, SW; Margolin, DA; Milsom, JW; Potenti, FM; Rafferty, JF; Riff, DS; Sands, LR; Senagore, A; Stamos, MJ; Yee, LF; Young-Fadok, TM, 2002)
"Interestingly, these migraine-associated single-nucleotide polymorphisms reside in noncoding regions of TRPM8, with those correlated with reduced migraine risk exhibiting lower TRPM8 expression and decreased cold sensitivity."	5.72	Transient receptor potential melastatin 8 is required for nitroglycerin- and calcitonin gene-related peptide-induced migraine-like pain behaviors in mice. ( Kim, B; McKemy, DD; Wei, C, 2022)
"Topiramate treatment prevented NTG-induced changes by reversing NTG-induced hyperalgesia and allodynia, and inhibiting CGRP and c-Fos gene expression in all areas evaluated."	5.48	Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing. ( Demartini, C; Greco, R; Tassorelli, C; Zanaboni, AM, 2018)
"5-mg nitroglycerin gel 30 min prior to IUD placement does not appear to decrease patient-reported procedural pain among nulliparous women or ease of insertion for providers."	5.19	The effect of nitroglycerin on the IUD insertion experience in nulliparous women: a pilot study. ( Bednarek, PH; Jensen, JT; Micks, EA, 2014)
" To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application."	5.17	Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013)
"A significantly higher proportion of patients in the placebo group (83 %) experienced pain compared to the lidocaine and combination groups (43 and 7 %, respectively; both, P < 0."	5.16	Reduction of pain on injection of propofol: combination of nitroglycerin and lidocaine. ( Jeon, Y, 2012)
"The NTG adding to lidocaine in intravenous regional anesthesia shortens onset times of sensory and motor block and decreases the tourniquet and postoperative pain, without any side effect."	5.14	The effect of nitroglycerin as an adjuvant to lidocaine in intravenous regional anesthesia. ( Abbasivash, R; Aghdashi, MM; Hassani, E; Shirvani, M, 2009)
"According to our study, there was no benefit regarding healing or pain relief, in treating patients suffering from an anal fissure with Nitroglycerin ointment in combination with stool softeners and sitz baths, compared to the same treatment without Nitroglycerin ointment."	5.11	[A prospective, randomized double-blind study on the treatment of anal fissures with Nitroglycerin ointment]. ( Gelertner, I; Halevy, A; Levy, N; Negri, M; Weinstein, D; Ziv, Y, 2004)
" Nimesulide is a preferential COX-2 inhibitor widely used to treat pain."	5.10	Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2003)
"To examine analgesia and adverse effects following transdermal application of nitroglycerine (a nitric oxide generator) combined with oral morphine, in cancer pain patients."	5.10	Double-blind evaluation of transdermal nitroglycerine as adjuvant to oral morphine for cancer pain management. ( Lauretti, GR; Pereira, NL; Perez, MV; Reis, MP, 2002)
" Nitroglycerin (NTG) administration commonly causes a headache with some features similar to those of a migraine."	5.09	The pharmacodynamics of sumatriptan in nitroglycerin-induced headache. ( Forrest, A; Fullerton, T; Gengo, FM; Komorowski-Swiatek, D, 1999)
"We have conducted a prospective double blind randomized and placebo controlled clinical study in 20 patients with shoulder pain syndrome caused by supraspinatus tendinitis to determine whether transdermal nitroglycerin (NTG) has analgesic action in this condition."	5.08	Successful treatment of shoulder pain syndrome due to supraspinatus tendinitis with transdermal nitroglycerin. A double blind study. ( Amado, JA; Berrazueta, JR; Losada, A; Ochoteco, A; Poveda, J; Riestra, A; Salas, E, 1996)
"Nitroglycerin (glyceryl trinitrate, CAS 55-63-0, NTG) administered with an oral spray may be more effective in relieving anginal pain than sublingual tablets especially when the patient's mouth is dry."	5.08	Studies on the response of nitroglycerin oral spray compared with sublingual tablets for angina pectoris patients with dry mouth. A multicenter trial. ( Fukui, S; Hori, M; Karita, M; Koretsune, Y; Matsuyama, T; Sato, H; Shimazu, T; Sugii, M; Taniguchi, T, 1997)
") lidocaine and topical nitroglycerin ointment in preventing pain during propofol injection."	5.08	Effects of topical nitroglycerin and intravenous lidocaine on propofol-induced pain on injection. ( Beven, M; Carpenter, T; Laseter, JT; Mascha, E; Maurer, WG; O'Hara, JR; Sprung, J, 1997)
" Our aim was to evaluate the feasibility of a pain-scoring method and to compare the response to sublingual administration of an isosorbide dinitrate (ISDN) tablet, ISDN spray or nitroglycerin (NTG) spray."	5.08	Pain scoring--a method for assessing acute antianginal therapy comparison of the response to acute sublingual administration of an isosorbide dinitrate tablet, isosorbide dinitrate spray and nitroglycerin spray in unstable angina. ( Brill, Z; Feigenberger, Z; Hod, H; Kaplinsky, E; Matetzky, S; Shachar, A; Shotan, A, 1998)
"Eighteen cluster headache patients and five controls were studied using ultrasound duplex techniques to measure blood flow in the common carotid arteries after nitroglycerin and placebo administration."	5.07	Pain induces decrease of blood flow in the common carotid arteries in cluster headache attacks. ( Hannerz, J; Jogestrand, T, 1993)
"To determine whether pain or discomfort could be provoked by adenosine in skeletal muscle and, if so, whether it was dependent on the vasodilatation produced by adenosine, eight male volunteers were given intra-arterial bolus injections of adenosine and glyceryl trinitrate into the forearm."	5.06	Adenosine injection into the brachial artery produces ischaemia like pain or discomfort in the forearm. ( Fredholm, BB; Jonzon, B; Kaijser, L; Sylvén, C, 1988)
" Preliminary experience from a randomized double-blind trial of diltiazem, a new calcium antagonist, has demonstrated a 90% reduction in pain episodes, with many patients becoming pain-free on the 240-mg daily dose."	5.05	Medical therapy of Prinzmetal's variant angina. ( Ginsburg, R; Lamb, I; Rosenthal, S; Schroeder, JS, 1980)
"To assess the effects of verapamil and nifedipine on left ventricular function at rest and during exercise in patients with Prinzmetal's variant angina pectoris, 10 patients (6 men and 4 women with a mean age of 52 years) with variant angina were each treated for 2 months periods with placebo, verapamil (400 +/- 80 mg/day, mean +/- standard deviation [SD]) and nifedipine (82 +/- 31 mg/day)."	5.05	Effect of verapamil and nifedipine on left ventricular function at rest and during exercise in patients with Prinzmetal's variant angina pectoris. ( Corbett, J; Dehmer, GJ; Hillis, LD; Johnson, SM; Lewis, SE; Mauritson, DR; Willerson, JT, 1981)
"4% Nitroglycerin ointment is an intra-anal formulation of nitroglycerin (glyceryl trinitrate) indicated for the treatment of chronic anal fissure pain."	4.83	0.4% nitroglycerin ointment : in the treatment of chronic anal fissure pain. ( Easthope, SE; Fenton, C; Wellington, K, 2006)
"Nitroglycerin (NTG)-induced headache is the most common side effect of nitrate therapy and negatively affects the quality of life."	4.31	The effect of local cold compresses for nitroglycerin-induced headache: An observational pretest-posttest study. ( Enç, N; Uğurlu, YK, 2023)
" Treatment with GLP-1R agonist liraglutide attenuated trigeminal allodynia and suppressed the protein levels of CM-associated molecules in the trigeminal nucleus caudalis (TNC)."	4.31	GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model. ( Jing, F; Pu, Y; Zou, Q, 2023)
"Repeated administration of nitroglycerin (NTG) or levcromakalim (LEV) was conducted to stimulate human migraine-like pain and establish two types of CMMs in mice."	4.12	A c-Fos activation map in nitroglycerin/levcromakalim-induced models of migraine. ( Li, Z; Liu, X; Ren, X; Wang, W; Wang, Y; Wu, S; Zhang, K; Zhu, C, 2022)
"This study aimed to investigate the antimigraine potential of quercetin in migraine pain induced by nitroglycerin (NTG), 10 mg/kg, intraperitoneal injection in rats."	4.12	Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. ( Alam, A; Almalki, HS; Alqarni, MH; Devi, S; Foudah, AI; Kumar, M; Salkini, MA, 2022)
" Then, nitroglycerin (NTG) (5 mg/kg/IP) was used to induce migraine and pain-related symptoms were recorded for 90 min."	3.96	Physical exercise enhances vulnerability to migraine headache associated with CGRP up-expression in trigeminal nucleus caudalis of stressed rats. ( Abbasnejad, M; Askari-Zahabi, K; Esmaeili-Mahani, S; Kooshki, R; Raoof, M; Shamsizadeh, A, 2020)
" We present the case of limb ischemia secondary to accidental intra-arterial buprenorphine/naloxone film injection successfully treated with sublingual nitroglycerin."	3.96	Use of Sublingual Nitrates for Management of Limb Ischemia Secondary to Inadvertent Intra-Arterial Buprenorphine/Naloxone (Suboxone®) Film Injection. ( Franqui-Rivera, H; Gonzalez-Cordero, A; Reyes, M; Rivera-Gonzalez, J, 2020)
"The NO donors nitroglycerin and sodium nitroprusside (SNP) induced allodynia (cold plate test) and hyperalgesia (hot plate test)."	3.79	St. John's wort relieves pain in an animal model of migraine. ( Galeotti, N; Ghelardini, C, 2013)
"To evaluate the use of topical lidocaine gel and glyceryl trinitrate ointment (GTN) vs placebo, in reducing anal pain and discomfort as an adjunct to periprostatic anesthesia because of probe insertion, during the use of transrectal ultrasonography (TRUS) prostate-guided biopsy in young patients."	3.77	Comparison between lidocaine and glyceryl trinitrate ointment for perianal-intrarectal local anesthesia before transrectal ultrasonography-guided prostate biopsy: a placebo-controlled trial. ( Gekas, A; Konstantinidis, C; Samarinas, M; Skriapas, K; Xanthis, S, 2011)
"Calcitonin gene-related peptide (CGRP) and substance P (SP) play an important role in the development of pain and hyperalgesia."	3.74	Role of calcitonin gene-related peptide and substance P in different models of pain. ( Buscone, S; Di Bella, P; Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2008)
"The chronic pain relieving effects following spinal administration of clonidine are probably connected to alpha2-adrenoreceptor-induced augmented synthesis of nitric oxide (NO) in the spinal cord."	3.73	Involvement of nitric oxide in clonidine-induced spinal analgesia. ( Aronov, S; Ben-Abraham, R; Givati-Divshi, D; Katz, Y, 2005)
"1% nitroglycerin on demand; 3: internal anal sphincterotomy if hypertrophy of the internal anal sphincter was demonstrated by anal ultrasonography and no improvement was confirmed with the previous steps of treatment)."	3.73	Sequential treatment for proctalgia fugax. Mid-term follow-up. ( Aguilella Diago, V; Elía Guedea, M; Gracia Solanas, JA; Martínez Díez, M; Ramírez Rodríguez, JM, 2005)
" The aim of the study was to investigate the additive effects of nitroglycerine combined with lornoxicam for acute pain in rats."	3.73	[The effects of combination of two lornoxicam doses and nitroglycerine on acute pain in rats]. ( Aydin, ON; Dost, T; Gürsoy, F; Oğurlu, M; Sen, S; Temuçin, S, 2005)
"Since a car accident a 29-year-old man had been suffering from chronic pain treated with injections of morphine and tilidine."	3.70	[Erroneous intravenous injection of adrenaline]. ( Kenel, F; Meier, M; Vogt, M, 1998)
" This report documents a therapeutic role for nitroglycerin, a nitric oxide donor, in the treatment of acutely thrombosed external hemorrhoids and anal fissure."	3.69	Treatment of benign anal disease with topical nitroglycerin. ( Gorfine, SR, 1995)
" We have investigated the central processing of cluster headache (CH) attacks provoked by sublingual nitroglycerin (NTG)."	3.69	Right-lateralised central processing for pain of nitroglycerin-induced cluster headache. ( Hannerz, J; Hsieh, JC; Ingvar, M, 1996)
"Eight patients with episodic cluster headache, five in active episode, three out of episode, were investigated as to diameters of intracranial arteries before and after nitroglycerin (NG) administration."	3.68	MRI of intracranial arteries in nitroglycerin induced cluster headache attacks. ( Greitz, D; Hannerz, J, 1992)
"A 62-year-old man who was under observation following an episode of severe chest pain developed complete heart block and hypotension after receiving sublingual nitroglycerin."	3.66	Complete heart block after sublingual nitroglycerin. ( Fenster, PE; Lancaster, L, 1983)
"Ergonovine administration during coronary angiography is frequently used to rule out coronary spasm as a cause of chest pain."	3.66	Provocative ergonovine testing in patients without obstructive coronary disease. ( Carabello, BA; Gash, AK, 1983)
"We reviewed our experience with the ergonovine provocative test for coronary arterial spasm in 40 patients with pain in the chest believed to be angina pectoris and in one patient with a myocardial infarction and normal coronary arteries."	3.66	Experience with ergonovine provocative testing for coronary arterial spasm. ( Adelman, AG; Huckell, VF; Johnstone, DE; Magder, SA, 1981)
"The pain is associated with ipsilateral autonomic symptoms (most commonly lacrimation, conjunctival injection, nasal congestion or rhinorrhea, ptosis, edema of the eyelid, sweating of the forehead or face, and miosis) and a sense of agitation or restlessness."	2.82	Cluster Headache: Rapid Evidence Review. ( Bailey, J; Hawks, MK; Malu, OO, 2022)
"The effects were independent of the dosage used."	2.82	Effectiveness of topical glyceryl trinitrate in treatment of tendinopathy - systematic review and meta-analysis. ( Johansson, J; Juhola, J; Kemppi, V; Saltychev, M, 2022)
"Headache was scored on a numerical verbal rating (0-10) scale."	2.73	Intracranial hemodynamics during intravenous infusion of glyceryl trinitrate. ( Friberg, L; Holm, S; Iversen, HK; Tfelt-Hansen, P, 2008)
"This study addressed the dose-response to three different concentrations of GTN ointment compared with placebo in a double blind randomised controlled trial."	2.71	A dose finding study with 0.1%, 0.2%, and 0.4% glyceryl trinitrate ointment in patients with chronic anal fissures. ( Athanasiadis, S; Bock, JU; Herold, A; Marla, B; Pröls, M; Richter, HJ; Scholefield, JH, 2003)
"Cramps, headaches, and whether or not a stoma bag was used were expressed as a percentage of number of irrigations."	2.70	Chemical colostomy irrigation with glyceryl trinitrate solution. ( Bossom, C; Gangoli, S; Green, C; O'Bichere, A; Phillips, RK, 2001)
" To assess whether an unattenuated antiischemic and antianginal efficacy during the hours of intermittent dosing can be maintained, a modified drug-release profile with increasing plasma concentrations was evaluated using a double-blind, placebo-controlled crossover protocol."	2.69	Increasing nitroglycerin release from patches enables circumvention of early nitrate tolerance. ( Lehmann, G; Reiniger, G, 1998)
"Median VAS for burning pain were 0 for the placebo, GTN and GTN + capsaicin groups and 3 for the capsaicin group after single application of each cream at daily intervals."	2.69	The addition of GTN to capsaicin cream reduces the discomfort associated with application of capsaicin alone. A volunteer study. ( McCleane, JG; McLaughlin, M, 1998)
"Pain was recorded on a linear analog scale."	2.69	Glyceryl trinitrate ointment for the treatment of chronic anal fissure: results of a placebo-controlled trial and long-term follow-up. ( Kennedy, ML; Lubowski, DZ; Nguyen, H; Sowter, S, 1999)
"Internal anal sphincterotomy for treating chronic anal fissure can irreversibly damage anal continence."	2.69	Glyceryl trinitrate for chronic anal fissure--healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial. ( Altomare, DF; Arcanà, F; Bottini, C; Lovreglio, R; Milito, G; Nardelli, N; Pescatori, M; Pulvirenti-D'Urso, A; Rinaldi, M; Scardigno, D; Spinelli, F, 2000)
"No patient had a headache or experienced postural hypotension."	2.67	Pain on injection of propofol: modification by nitroglycerin. ( Anderson, M; Gauntlett, IS; Wilkinson, D, 1993)
"Nitroglycerin (NTG) has the potential to reduce myocardial ischemia during percutaneous transluminal coronary angioplasty (PTCA)."	2.67	Buccal nitroglycerin decreases ischemic pain during coronary angioplasty: a double-blind, randomized, placebo-controlled study. ( Ekström, L; Emanuelsson, H; Johansson, SR, 1990)
"Lidoflazine is a synthetic drug with calcium-channel blocking effects."	2.65	The effects of lidoflazine on exercise performance and thallium stress scintigraphy in patients with stable angina pectoris. ( Narahara, KA; Park, J; Shapiro, W, 1982)
"Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models."	2.61	Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. ( Borsook, D; De Icco, R; Demartini, C; Greco, R; Sances, G; Tassorelli, C; Zanaboni, AM, 2019)
"Achilles tendinopathy is generally caused by chronic stress to the tendon, leading to a defective arrangement of collagen fibers in the Achilles tendon."	2.44	Noninsertional Achilles tendinopathy: pathology and management. ( McCabe, F; McShane, JM; Ostick, B, 2007)
"Animal models for migraine have provided substantial advances on the mechanisms and mediators underlying migraine attacks."	2.42	Peripheral and central activation of trigeminal pain pathways in migraine: data from experimental animal models. ( Buzzi, MG; Nappi, G; Tassorelli, C, 2003)
"In the acute migraine model, rats received CBD (15 mg or 30 mg/kg, i."	1.91	Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine. ( Demartini, C; Facchetti, S; Francavilla, M; Franco, V; Greco, R; Pacchetti, B; Palmisani, M; Sodergren, MH; Tassorelli, C; Zanaboni, AM, 2023)
"The mechanism of SGD in remedying migraine was studied through transcriptome sequencing (RNA-seq), which was further validated utilizing Elisa, Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting (WB) experiments."	1.91	Shaoyao Gancao decoction alleviates the central hyperalgesia of recurrent NTG-induced migraine in rats by regulating the NGF/TRPV1/COX-2 signal pathway. ( Hou, J; Ji, X; Li, R; Liu, Z; Luo, Y; Qiu, Y; Song, H; Tao, X; Wang, T; Yang, F; Zhang, S; Zhang, Y; Zhou, R, 2023)
"Nitroglycerin-induced hyperalgesia was evaluated in mice with different gut microbiota statuses as follows: Specific pathogen-free mice; germ-free mice; specific pathogen-free mice treated with antibiotics to deplete the gut microbiome (ABX mice); and germ-free mice transplanted with the gut microbial profile from specific pathogen-free mice (GFC mice)."	1.72	The gut microbiome modulates nitroglycerin-induced migraine-related hyperalgesia in mice. ( Kang, L; Kong, S; Li, Y; Liu, J; Tang, W; Yu, S; Zhang, M; Zhang, Y; Zhao, D, 2022)
"Contrary to previous results with the migraine-inducing substances glyceryl trinitrate, cilostazol and levcromakalim, PACAP-38-induced hypersensitivity worked only partially through inhibition of ATP-sensitive potassium channels."	1.72	The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target? ( Christensen, SL; Ernstsen, C; Jansen-Olesen, I; Kristensen, DM; Nielsen, BS; Olesen, J; Rasmussen, RH, 2022)
"Interestingly, these migraine-associated single-nucleotide polymorphisms reside in noncoding regions of TRPM8, with those correlated with reduced migraine risk exhibiting lower TRPM8 expression and decreased cold sensitivity."	1.72	Transient receptor potential melastatin 8 is required for nitroglycerin- and calcitonin gene-related peptide-induced migraine-like pain behaviors in mice. ( Kim, B; McKemy, DD; Wei, C, 2022)
"Converging evidence shows that migraine is associated with gastrointestinal disorders."	1.72	Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine. ( Campolo, M; Casili, G; Cuzzocrea, S; Esposito, E; Filippone, A; Giuffrè, L; Lanza, M; Paterniti, I; Scuderi, SA, 2022)
"Migraine is a complex neurovascular disorder characterized by recurrent attacks of pain and other associated symptoms."	1.72	Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior. ( Demartini, C; Francavilla, M; Greco, R; Tassorelli, C; Zanaboni, AM, 2022)
"Evodiamine (EVO) is a natural compound derived from Tetradium ruticarpum (A."	1.56	Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response. ( Chen, J; Li, C; Li, Z; Lin, J; Lu, H; Wu, Z; Yang, X; Zhang, X; Zhang, Y, 2020)
"Furthermore, NTG-induced migraine-like pain in GF mice was markedly enhanced compared to that in WT mice and gut colonization with fecal microbiota from WT mice robustly reversed microbiota deprivation-caused pain enhancement."	1.56	Gut Microbiota Dysbiosis Enhances Migraine-Like Pain Via TNFα Upregulation. ( Liu, S; Shu, H; Tang, Y; Tao, F; Yanagisawa, L, 2020)
"Pretreatment with PL ameliorated migraine headache behaviors in the NTG-induced migraine rat model, suggesting pretreatment with PL is beneficial for migraine headache treatment."	1.51	Effect of Paeonia lactiflora, a traditional Chinese herb, on migraines based on clinical application and animal behavior analyses. ( Chen, CH; Hsieh, CL; Li, JM; Liao, CC; Lin, CL, 2019)
"Glyceryl trinitrate causes prolonged mechanical allodynia in rodents, which temporally correlates with delayed glyceryl trinitrate-evoked migraine attacks in patients."	1.48	TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice. ( Benemei, S; Bunnett, NW; De Carvalho Goncalves, M; De Logu, F; Ferreira, J; Geppetti, P; Jain, P; Li Puma, S; Marone, IM; Materazzi, S; Nassini, R, 2018)
"Topiramate treatment prevented NTG-induced changes by reversing NTG-induced hyperalgesia and allodynia, and inhibiting CGRP and c-Fos gene expression in all areas evaluated."	1.48	Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing. ( Demartini, C; Greco, R; Tassorelli, C; Zanaboni, AM, 2018)
"Limited systemic sclerosis, including CREST syndrome, manifests as fibrotic skin changes restricted to the hands and face, with vascular, musculoskeletal, and visceral involvement."	1.48	Botulinum toxin for treatment of Raynaud phenomenon in CREST syndrome. ( Berk-Krauss, J; Christman, MP; Franks, A; Liebman, TN; Sicco, KL, 2018)
"Pain and constipation were assessed prior to treatment and at 6 weeks after therapy using visual analogue scale (VAS) and Wexner constipation score."	1.46	Does the duration of symptoms of anal fissure impact its response to conservative treatment? A prospective cohort study. ( Abdelmawla, AA; Abdelnaby, M; Elfeki, H; Elgendy, H; Emile, SH; Khafagy, W; Magdy, A, 2017)
"An optimal therapy for migraine has not yet been developed."	1.43	Pharmacological characterization of a novel gastrodin derivative as a potential anti-migraine agent. ( Chen, C; Du, JR; Long, FY; Mao, XN; Wan, JY; Wang, PH; Zhang, L; Zhang, S; Zhao, LX, 2016)
"Nitroglycerin pre-treated animals did not show any rubbing behavior after locally injected saline."	1.40	Correlation between algogenic effects of calcitonin-gene-related peptide (CGRP) and activation of trigeminal vascular system, in an in vivo experimental model of nitroglycerin-induced sensitization. ( Capuano, A; Greco, MC; Navarra, P; Tringali, G, 2014)
"(1) Anal fissures are very painful but often heal spontaneously."	1.35	0.4% glyceryl trinitrate ointment: new drug. Not useful for anal fissures. ( , 2008)
"Although headache is a frequent side-effect, it is usually transient and glyceryl trinitrate does not seem to have any long-term adverse effects."	1.35	[The role of glyceryl trinitrate in the treatment of anal fissure]. ( Bursics, A; Takáts, K; Tóth, A, 2008)
"Nitroglycerin-induced hyperalgesia can be detected as an increase in the nociceptive behavior evoked by the formalin test."	1.33	Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C; Wang, D, 2006)
"Radial artery spasm is a frequent complication of the transradial approach for coronary angiography and angioplasty."	1.32	Evaluation of a spasmolytic cocktail to prevent radial artery spasm during coronary procedures. ( Eccleshall, SC; Kiemeneij, F; Laarman, G; Slagboom, T; Vajifdar, BU; van der Wieken, R, 2003)
"Nitroglycerin is a nitric oxide (NO) donor which activates nuclei involved in nociceptive transmission following systemic administration."	1.32	Nitroglycerin induces hyperalgesia in rats--a time-course study. ( Greco, R; Nappi, G; Sandrini, G; Sandrini, M; Tassorelli, C; Wang, D, 2003)
"Contemporary approaches to the diagnosis and treatment of acute coronary syndromes have revolutionized the role of the nurse in the coronary care unit."	1.27	Nursing management of the patient with acute myocardial infarction. ( Boone, S; Del Negro, AA, 1986)
"Usually such pains are observed in patients with 2 and more cornary arteries affected by the disease."	1.25	[Clinical characteristics of angina pectoris in relation to disease of the coronary arteries]. ( Buslenko, NS; Fitileva, LM; Zingerman, LS, 1975)

Research

Studies (191)

Authors

Clinical Trials (8)

Trial Overview

Trial Outcomes

Change From Baseline in Pain Intensity at Days 14-18

Timeframe	Studies, this research(%)	All Research%
pre-1990	70 (36.65)	18.7374
1990's	27 (14.14)	18.2507
2000's	47 (24.61)	29.6817
2010's	26 (13.61)	24.3611
2020's	21 (10.99)	2.80

Authors	Studies
Kang, L	1
Tang, W	1
Zhang, Y	4
Zhang, M	1
Liu, J	1
Li, Y	1
Kong, S	1
Zhao, D	1
Yu, S	1
Lanza, M	2
Filippone, A	2
Ardizzone, A	1
Casili, G	2
Paterniti, I	2
Esposito, E	2
Campolo, M	2
Malu, OO	1
Bailey, J	1
Hawks, MK	1
Ernstsen, C	1
Christensen, SL	1
Rasmussen, RH	1
Nielsen, BS	1
Jansen-Olesen, I	1
Olesen, J	2
Kristensen, DM	1
Wei, C	1
Kim, B	1
McKemy, DD	1
Giuffrè, L	1
Scuderi, SA	1
Cuzzocrea, S	1
Greco, R	10
Demartini, C	5
Zanaboni, AM	5
Francavilla, M	3
Reggiani, A	1
Realini, N	1
Scarpelli, R	1
Piomelli, D	1
Tassorelli, C	13
Uğurlu, YK	1
Enç, N	1
Wu, S	1
Ren, X	1
Zhu, C	1
Wang, W	1
Zhang, K	1
Li, Z	2
Liu, X	1
Wang, Y	1
Mustafa, G	1
Hossain, MS	1
Sheikh, SH	1
Faruk, I	1
Taher, MA	1
Ferdaus, AM	1
Fatema, B	1
Alam, A	4
Tasnim, T	1
Foudah, AI	3
Devi, S	3
Alqarni, MH	3
Salkini, MA	3
Kumar, M	3
Almalki, HS	3
Sodergren, MH	1
Facchetti, S	1
Pacchetti, B	1
Palmisani, M	1
Franco, V	1
Luo, Y	1
Qiu, Y	1
Zhou, R	1
Ji, X	1
Liu, Z	1
Li, R	1
Yang, F	1
Hou, J	1
Zhang, S	2
Wang, T	1
Song, H	1
Tao, X	1
Jing, F	1
Zou, Q	1
Pu, Y	1
Lin, J	1
Zhang, X	1
Li, C	1
Lu, H	1
Chen, J	1
Yang, X	1
Wu, Z	1
Kooshki, R	1
Abbasnejad, M	1
Shamsizadeh, A	1
Raoof, M	1
Askari-Zahabi, K	1
Esmaeili-Mahani, S	1
Rivera-Gonzalez, J	1
Gonzalez-Cordero, A	1
Reyes, M	1
Franqui-Rivera, H	1
Saltychev, M	1
Johansson, J	1
Kemppi, V	1
Juhola, J	1
Emile, SH	1
Elgendy, H	1
Elfeki, H	1
Magdy, A	1
Abdelmawla, AA	1
Abdelnaby, M	1
Khafagy, W	1
Marone, IM	1
De Logu, F	1
Nassini, R	1
De Carvalho Goncalves, M	1
Benemei, S	1
Ferreira, J	1
Jain, P	1
Li Puma, S	1
Bunnett, NW	1
Geppetti, P	1
Materazzi, S	1
Challoumas, D	1
Kirwan, PD	1
Borysov, D	1
Clifford, C	1
McLean, M	1
Millar, NL	1
Berk-Krauss, J	1
Christman, MP	1
Franks, A	1
Sicco, KL	1
Liebman, TN	1
Sances, G	2
De Icco, R	1
Borsook, D	1
Jovin, IS	1
Rajab, M	1
Newman, M	1
Collie, M	1
Liao, CC	1
Li, JM	1
Chen, CH	1
Lin, CL	1
Hsieh, CL	1
Tang, Y	1
Liu, S	1
Shu, H	1
Yanagisawa, L	1
Tao, F	1
Hu, YJ	1
Wei, AN	1
Chook, P	1
Yin, Y	1
Cheng, W	1
Wu, MJ	1
Celermajer, DS	1
Woo, KS	1
Berry, SM	1
Barish, CF	1
Bhandari, R	1
Clark, G	1
Collins, GV	1
Howell, J	1
Pappas, JE	1
Riff, DS	2
Safdi, M	1
Yellowlees, A	1
Micks, EA	1
Jensen, JT	1
Bednarek, PH	1
Capuano, A	1
Greco, MC	1
Navarra, P	1
Tringali, G	1
Wang, PH	1
Zhao, LX	1
Wan, JY	1
Zhang, L	1
Mao, XN	1
Long, FY	1
Chen, C	1
Du, JR	1
Zapata, LB	1
Jatlaoui, TC	1
Marchbanks, PA	1
Curtis, KM	1
Armentero, MT	1
Sandrini, G	6
Nappi, G	8
Blandini, F	1
Takáts, K	1
Tóth, A	1
Bursics, A	1
Agrawal, RP	1
Goswami, J	1
Jain, S	1
Kochar, DK	1
Di Clemente, L	1
Coppola, G	1
Magis, D	1
Gérardy, PY	1
Fumal, A	1
De Pasqua, V	1
Di Piero, V	1
Schoenen, J	1
McCallum, SD	1
Paoloni, JA	2
Murrell, GA	2
Abbasivash, R	1
Hassani, E	1
Aghdashi, MM	1
Shirvani, M	1
Osadnik, R	1
Redeker, J	1
Kraemer, R	1
Vogt, PM	1
Knobloch, K	1
Gambito, ED	1
Gonzalez-Suarez, CB	1
Oquiñena, TI	1
Agbayani, RB	1
Hamza, M	1
Wang, XM	1
Wu, T	1
Brahim, JS	1
Rowan, JS	1
Dionne, RA	1
Cho, KI	1
Lee, JH	1
Kim, SM	1
Lee, HG	1
Kim, TI	1
Perrotta, A	1
Serrao, M	1
Arce-Leal, N	1
Guaschino, E	1
Rossi, P	1
Bartolo, M	1
Pierelli, F	1
Skriapas, K	1
Konstantinidis, C	1
Samarinas, M	1
Xanthis, S	1
Gekas, A	1
Alcock, R	1
Lowe, HC	1
Jeon, Y	1
Galeotti, N	1
Ghelardini, C	1
Bailey, HR	1
Beck, DE	1
Billingham, RP	1
Binderow, SR	1
Gottesman, L	1
Hull, TL	1
Larach, SW	1
Margolin, DA	1
Milsom, JW	1
Potenti, FM	1
Rafferty, JF	1
Sands, LR	2
Senagore, A	1
Stamos, MJ	1
Yee, LF	1
Young-Fadok, TM	1
Gibbons, RD	1
Scholefield, JH	2
Bock, JU	1
Marla, B	1
Richter, HJ	1
Athanasiadis, S	1
Pröls, M	1
Herold, A	1
Kiemeneij, F	1
Vajifdar, BU	1
Eccleshall, SC	1
Laarman, G	1
Slagboom, T	1
van der Wieken, R	1
Wang, D	2
Sandrini, M	1
Turan, A	1
Karamanlioğlu, B	1
Memiş, D	1
Pamukçu, Z	1
Buzzi, MG	1
Cecchi, LM	1
Lerer, T	1
Herson, VC	1
Rayman, G	1
Baker, NR	1
Krishnan, ST	1
DURRER, D	1
SNABL, P	1
PAVELKA, B	1
MACHALEK, M	1
SUSTA, A	1
KLEINHAMPLOVA, J	1
PERSIN, M	1
MCELROY, JB	1
BERNARD, R	1
BARKAN, MB	1
MCCARROLL, HR	1
PRIEST, WS	1
COMPERE, EL	1
BEATTIE, EJ	1
BUCY, PC	1
Isbister, GK	1
Bonham, RJ	1
Higa, M	1
Takasu, N	1
Tamanaha, T	1
Nakamura, K	1
Shimabukuro, M	1
Sasara, T	1
Tawata, M	1
Weinstein, D	1
Halevy, A	1
Negri, M	1
Levy, N	1
Gelertner, I	1
Ziv, Y	1
Rochester, MA	1
LE Monnier, K	1
Brewster, SF	1
Appleyard, RC	1
Nelson, J	1
Aronov, S	2
Ben-Abraham, R	2
Givati-Divshi, D	2
Katz, Y	2
Little, M	1
Gracia Solanas, JA	1
Ramírez Rodríguez, JM	1
Elía Guedea, M	1
Aguilella Diago, V	1
Martínez Díez, M	1
Rochester, M	1
Brewster, S	1
Fenton, C	1
Wellington, K	1
Easthope, SE	1
Nelson, R	1
Lund, JN	2
Sen, S	1
Dost, T	1
Aydin, ON	1
Oğurlu, M	1
Temuçin, S	1
Gürsoy, F	1
Siński, M	1
Lewandowski, J	1
Abramczyk, P	1
Nowosad, H	1
Grzelak-Szafrańiska, H	1
McCabe, JE	1
Hanchanale, VS	1
Philip, J	1
Javle, PM	1
McShane, JM	1
Ostick, B	1
McCabe, F	1
Giannarini, G	1
Mogorovich, A	1
De Maria, M	1
Selli, C	1
Di Bella, P	1
Buscone, S	1
Iversen, HK	2
Holm, S	1
Friberg, L	1
Tfelt-Hansen, P	1
Rodman, MJ	1
Hecht, HS	2
Rahimtoola, SH	1
Broustet, JP	1
Pic, A	1
Laurentjoye, P	1
Douard, H	1
Mora, B	1
Lancaster, L	1
Fenster, PE	1
Carabello, BA	1
Gash, AK	1
Blackwell, JN	1
Castell, DO	1
Przybojewski, JZ	1
Levine, HJ	1
Schroeder, JS	1
Rosenthal, S	1
Ginsburg, R	1
Lamb, I	1
Magder, SA	1
Johnstone, DE	1
Huckell, VF	1
Adelman, AG	1
Rudoph, W	1
Dirschinger, J	1
Johnson, SM	1
Mauritson, DR	1
Corbett, J	1
Dehmer, GJ	1
Lewis, SE	1
Willerson, JT	1
Hillis, LD	1
Ferguson, SC	1
Hodges, K	1
Hersh, T	1
Jinich, H	1
Yamamoto, K	1
Koiwaya, Y	1
Tajimi, T	1
Inou, T	1
Mitsutake, A	1
Orita, Y	1
Takeshita, A	1
Nakamura, M	1
Brown, BG	1
Josephson, MA	1
Petersen, RB	1
Pierce, CD	1
Wong, M	1
Bolson, E	1
Dodge, HT	1
Shapiro, W	1
Narahara, KA	1
Park, J	1
Ilsley, C	1
Canepa-Anson, R	1
Langley, G	1
Foale, R	1
Poole-Wilson, P	1
Rickards, A	1
Hickam, DH	1
Sox, HC	1
Marton, KI	1
Skeff, KM	1
Chin, D	1
Gorfine, SR	2
Robinson, D	1
Yesavage, J	1
Tinklenberg, J	1
Wilkinson, D	1
Anderson, M	1
Gauntlett, IS	1
Hannerz, J	3
Jogestrand, T	1
Pittrof, R	1
Lees, C	1
Thompson, C	1
Pickles, A	1
Martin, JF	1
Campbell, S	1
Michael, A	1
Andrew, M	2
Berrazueta, JR	1
Losada, A	1
Poveda, J	1
Ochoteco, A	1
Riestra, A	1
Salas, E	1
Amado, JA	1
Hsieh, JC	1
Ingvar, M	1
Sato, H	1
Koretsune, Y	1
Taniguchi, T	1
Fukui, S	1
Shimazu, T	1
Sugii, M	1
Matsuyama, T	1
Karita, M	1
Hori, M	1
O'Hara, JR	1
Sprung, J	1
Laseter, JT	1
Maurer, WG	1
Carpenter, T	1
Beven, M	1
Mascha, E	1
Christensen, MH	1
Schulze, S	1
Rosenberg, J	1
Coperchini, ML	1
Kreeger, LC	1
Shotan, A	1
Brill, Z	1
Matetzky, S	1
Shachar, A	1
Feigenberger, Z	1
Hod, H	1
Kaplinsky, E	1
Meier, M	1
Kenel, F	1
Vogt, M	1
Reiniger, G	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Neurophysiological, Biomolecular and Psychological Aspects of Erenumab Treatment in Chronic Migraine: an Open Label, Hypothesis Generator Study[NCT04361721]		40 participants (Anticipated)	Observational	2020-01-15	Recruiting
A Multidisciplinary Approach to the Identification of BIOmarkers of MIGraine: a Proof of Concept Study Based on the Stratification of Responders to CGRP Monoclonal Antibodies[NCT04503083]		219 participants (Anticipated)	Observational	2021-01-15	Recruiting
Habituation of the Nociceptive Blink Reflex in Experimentally Induced Migraine Attack: a Cross-over, Randomized Controlled Study[NCT05718310]		22 participants (Anticipated)	Interventional	2022-11-01	Recruiting
Perioperative Endothelial Dysfunction in Patients Undergoing Minor Abdominal Surgery. The POETRY Minor Study.[NCT02690233]		60 participants (Actual)	Observational	2016-02-29	Completed
A Randomized. Double-blind, Placebo-controlled, Multi-national Study to Determine the Effect of Cellegesic Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With a Chronic Anal Fissure[NCT00522041]	Phase 3	248 participants (Actual)	Interventional	2007-08-31	Completed
Effectiveness of Stromal Vascular Fraction (SVF) and Platelets Rich Plasma (PRP) in Osteoarthritis and Tendinopathy: Study Protocol for a Phase III, Prospective, Randomized, Controlled Multi-center Study: (SPOT Study).[NCT05660824]	Phase 4	195 participants (Anticipated)	Interventional	2023-06-30	Not yet recruiting
TENDOSHOCK-2010 - Combined Sclerosing Therapy, Extracorporeal Shockwave Therapy, Eccentric Training and Topical Glyceryl Trinitrate for Athletic Tendinopathies[NCT01185951]	Phase 2	114 participants (Actual)	Interventional	2007-01-31	Active, not recruiting
Effect of Nitroglycerin Ointment on Mastectomy Flap Necrosis[NCT01608880]		154 participants (Actual)	Interventional	2012-08-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated and used to determine the change from Baseline. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A negative change score indicated improvement." (NCT00522041)
Timeframe: Baseline to Day 18

Percentage of Responders

Intervention	Units on a scale (Mean)
Cellegesic (Nitroglycerin 0.4%)	-40.4
Placebo	-34.9

"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A responder was defined as a participant with either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in the 24 hour average pain intensity averaged over Days 14 to 18." (NCT00522041)
Timeframe: Baseline to Day 18

Time to an Improvement in Pain Intensity

Intervention	Percentage of responders (Number)
	≥ 50% decrease	≥ 10 mm decrease
Cellegisic (Nitroglycerin 0.4%)	72.4	88.6
Placebo	64.5	85.5

"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale (VAS) at Baseline and on each of the 21 treatment days of the study. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. Improvement was defined as either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in rated pain intensity." (NCT00522041)
Timeframe: Baseline to Day 21

Article	Year
Cluster Headache: Rapid Evidence Review. American family physician, 2022, 01-01, Volume: 105, Issue:1 Topics: Adult; Alcohol Drinking; Cluster Headache; Female; Humans; Male; Nitrates; Nitroglycerin; Oxygen; Pa	2022
Effectiveness of topical glyceryl trinitrate in treatment of tendinopathy - systematic review and meta-analysis. Disability and rehabilitation, 2022, Volume: 44, Issue:20 Topics: Achilles Tendon; Glycerol; Humans; Nitroglycerin; Pain; Tendinopathy; Tennis Elbow	2022
Topical glyceryl trinitrate for the treatment of tendinopathies: a systematic review. British journal of sports medicine, 2019, Volume: 53, Issue:4 Topics: Achilles Tendon; Activities of Daily Living; Administration, Cutaneous; Cumulative Trauma Disorders;	2019
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. Progress in neurobiology, 2019, Volume: 177 Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents	2019
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. Progress in neurobiology, 2019, Volume: 177 Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents	2019
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. Progress in neurobiology, 2019, Volume: 177 Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents	2019
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. Progress in neurobiology, 2019, Volume: 177 Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents	2019
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. Progress in neurobiology, 2019, Volume: 177 Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents	2019
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. Progress in neurobiology, 2019, Volume: 177 Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents	2019
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. Progress in neurobiology, 2019, Volume: 177 Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents	2019
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. Progress in neurobiology, 2019, Volume: 177 Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents	2019
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. Progress in neurobiology, 2019, Volume: 177 Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents	2019
Medications to ease intrauterine device insertion: a systematic review. Contraception, 2016, Volume: 94, Issue:6 Topics: Equipment Safety; Female; Humans; Intrauterine Devices; Misoprostol; Nitroglycerin; Nitroprusside; P	2016
Five-year prospective comparison study of topical glyceryl trinitrate treatment of chronic lateral epicondylosis at the elbow. British journal of sports medicine, 2011, Volume: 45, Issue:5 Topics: Administration, Topical; Adult; Aged; Chronic Disease; Follow-Up Studies; Humans; Male; Middle Aged;	2011
Evidence on the effectiveness of topical nitroglycerin in the treatment of tendinopathies: a systematic review and meta-analysis. Archives of physical medicine and rehabilitation, 2010, Volume: 91, Issue:8 Topics: Acute Disease; Administration, Cutaneous; Chronic Disease; Clinical Trials as Topic; Humans; Nitrogl	2010
A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures. Diseases of the colon and rectum, 2002, Volume: 45, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Double-Blind Method; Drug Administration Schedule;	2002
Peripheral and central activation of trigeminal pain pathways in migraine: data from experimental animal models. Cephalalgia : an international journal of headache, 2003, Volume: 23 Suppl 1 Topics: Animals; Brain; Migraine Disorders; Models, Animal; Neurogenic Inflammation; Nitric Oxide; Nitric Ox	2003
0.4% nitroglycerin ointment : in the treatment of chronic anal fissure pain. Drugs, 2006, Volume: 66, Issue:3 Topics: Administration, Topical; Chronic Disease; Drug Administration Schedule; Fissure in Ano; Humans; Nitr	2006
Noninsertional Achilles tendinopathy: pathology and management. Current sports medicine reports, 2007, Volume: 6, Issue:5 Topics: Achilles Tendon; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Di	2007
What is the role of coronary bypass surgery in patients with unstable angina? Cardiovascular clinics, 1983, Volume: 13, Issue:1 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Bed Rest; Coronary Angiography; Coronary Artery Bypass	1983
Difficult problems in the diagnosis of chest pain. American heart journal, 1980, Volume: 100, Issue:1 Topics: Angina Pectoris; Basal Cell Nevus Syndrome; Cardiomyopathy, Hypertrophic; Coronary Disease; Diagnosi	1980
A nonsurgical approach to chronic anal fissure. Hospital practice (1995), 1997, Sep-15, Volume: 32, Issue:9 Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Pain; Risk Factors;	1997
Acephalgic migraine. Headache, 1986, Volume: 26, Issue:4 Topics: Abdomen; Amnesia; Confusion; Coronary Vasospasm; Diagnosis, Differential; Ergotamine; Ergotamines; H	1986
Evaluation of acute chest pain. The Medical clinics of North America, 1973, Volume: 57, Issue:6 Topics: Acute Disease; Angina Pectoris; Aortic Aneurysm; Coronary Disease; Diagnosis, Differential; Electroc	1973

Article	Year
Clinical Outcome of 0.2% Glyceryl Trinitrate Topical Ointment Compared to Lateral Internal Sphincterotomy in the Treatment of Patient with Chronic Anal Fissure: A Randomized Control Trial. Mymensingh medical journal : MMJ, 2022, Volume: 31, Issue:4 Topics: Administration, Topical; Adult; Anal Canal; Chronic Disease; Female; Fissure in Ano; Humans; Lateral	2022
Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. BMC gastroenterology, 2013, Jul-01, Volume: 13 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Fissu	2013
The effect of nitroglycerin on the IUD insertion experience in nulliparous women: a pilot study. Contraception, 2014, Volume: 90, Issue:1 Topics: Administration, Intravaginal; Adult; Double-Blind Method; Female; Humans; Intrauterine Devices, Medi	2014
Management of diabetic neuropathy by sodium valproate and glyceryl trinitrate spray: a prospective double-blind randomized placebo-controlled study. Diabetes research and clinical practice, 2009, Volume: 83, Issue:3 Topics: Alanine Transaminase; Aspartate Aminotransferases; Diabetes Mellitus, Type 2; Diabetic Neuropathies;	2009
Nitroglycerin sensitises in healthy subjects CNS structures involved in migraine pathophysiology: evidence from a study of nociceptive blink reflexes and visual evoked potentials. Pain, 2009, Volume: 144, Issue:1-2 Topics: Adult; Analysis of Variance; Blinking; Dose-Response Relationship, Drug; Drug Administration Routes;	2009
The effect of nitroglycerin as an adjuvant to lidocaine in intravenous regional anesthesia. Middle East journal of anaesthesiology, 2009, Volume: 20, Issue:2 Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Double-Blind Method; Drug Therapy, Combination; F	2009
Nitric oxide is negatively correlated to pain during acute inflammation. Molecular pain, 2010, Sep-15, Volume: 6 Topics: Acute Disease; Adolescent; Adult; Female; Gene Expression Regulation, Enzymologic; Humans; Inflammat	2010
Oral nitric-oxide donor glyceryl-trinitrate induces sensitization in spinal cord pain processing in migraineurs: a double-blind, placebo-controlled, cross-over study. European journal of pain (London, England), 2011, Volume: 15, Issue:5 Topics: Administration, Oral; Administration, Sublingual; Adult; Cross-Over Studies; Double-Blind Method; Fe	2011
Reduction of pain on injection of propofol: combination of nitroglycerin and lidocaine. Journal of anesthesia, 2012, Volume: 26, Issue:5 Topics: Adult; Anesthetics, Intravenous; Double-Blind Method; Elective Surgical Procedures; Female; Humans;	2012
A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures. Diseases of the colon and rectum, 2002, Volume: 45, Issue:9 Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Double-Blind Method; Drug Administration Schedule;	2002
A dose finding study with 0.1%, 0.2%, and 0.4% glyceryl trinitrate ointment in patients with chronic anal fissures. Gut, 2003, Volume: 52, Issue:2 Topics: Adult; Anal Canal; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; F	2003
Can nitroglycerine ointment facilitate newborn heelstick blood collection? A randomized controlled trial. Journal of perinatology : official journal of the California Perinatal Association, 2003, Volume: 23, Issue:4 Topics: Administration, Topical; Blood Pressure; Blood Specimen Collection; Crying; Double-Blind Method; Fem	2003
Glyceryl trinitrate patches as an alternative to isosorbide dinitrate spray in the treatment of chronic painful diabetic neuropathy. Diabetes care, 2003, Volume: 26, Issue:9 Topics: Administration, Cutaneous; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathi	2003
Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia. Drugs, 2003, Volume: 63 Suppl 1 Topics: Analgesia; Animals; Brain; Disease Models, Animal; Gene Expression; Genes, fos; Hyperalgesia; Male;	2003
[A prospective, randomized double-blind study on the treatment of anal fissures with Nitroglycerin ointment]. Harefuah, 2004, Volume: 143, Issue:10 Topics: Double-Blind Method; Fissure in Ano; Humans; Nitroglycerin; Ointments; Pain; Pain Measurement; Place	2004
A double-blind, randomized, controlled trial of topical glyceryl trinitrate for transrectal ultrasound guided prostate biopsy. The Journal of urology, 2005, Volume: 173, Issue:2 Topics: Administration, Topical; Aged; Biopsy; Double-Blind Method; Humans; Male; Nitroglycerin; Pain; Prost	2005
Topical glyceryl trinitrate application in the treatment of chronic supraspinatus tendinopathy: a randomized, double-blinded, placebo-controlled clinical trial. The American journal of sports medicine, 2005, Volume: 33, Issue:6 Topics: Administration, Topical; Adult; Aged; Chronic Disease; Double-Blind Method; Female; Humans; Male; Mi	2005
[Comparison of the effect of nitroglycerine and pentaerithritol compositum on exercise time restricted by anginal pain or objective parameters of ischaemia in patients with stable angina]. Polskie Archiwum Medycyny Wewnetrznej, 2005, Volume: 114, Issue:2 Topics: Aged; Angina Pectoris; Chest Pain; Double-Blind Method; Exercise Test; Female; Humans; Male; Middle	2005
A randomized controlled trial of topical glyceryl trinitrate before transrectal ultrasonography-guided biopsy of the prostate. BJU international, 2007, Volume: 100, Issue:3 Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Biopsy, Needle; Humans;	2007
Intracranial hemodynamics during intravenous infusion of glyceryl trinitrate. The journal of headache and pain, 2008, Volume: 9, Issue:3 Topics: Adult; Blood Flow Velocity; Cerebrovascular Circulation; Female; Hemodynamics; Humans; Infusions, In	2008
[Stress tests limited by the symptoms in the evaluation of drug treatment of angina pectoris]. Archives des maladies du coeur et des vaisseaux, 1983, Volume: 76 Spec No Topics: Administration, Oral; Adrenergic beta-Antagonists; Angina Pectoris; Blood Pressure; Calcium Channel	1983
Medical therapy of Prinzmetal's variant angina. Chest, 1980, Volume: 78, Issue:1 Suppl Topics: Angina Pectoris; Angina Pectoris, Variant; Benzazepines; Clinical Trials as Topic; Diltiazem; Double	1980
Effect of verapamil and nifedipine on left ventricular function at rest and during exercise in patients with Prinzmetal's variant angina pectoris. The American journal of cardiology, 1981, Volume: 47, Issue:6 Topics: Angina Pectoris; Angina Pectoris, Variant; Exercise Test; Female; Heart Ventricles; Hemodynamics; Hu	1981
The effects of lidoflazine on exercise performance and thallium stress scintigraphy in patients with stable angina pectoris. Circulation, 1982, Volume: 65, Issue:1 Pt 2 Topics: Angina Pectoris; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; Double-Blind Meth	1982
R-wave amplitude and left ventricular volume: changes with nitroglycerine and atrial pacing. Cardiology, 1981, Volume: 68 Suppl 2 Topics: Angiography; Cardiac Catheterization; Cardiac Pacing, Artificial; Cardiac Volume; Coronary Disease;	1981
Nitroglycerin-induced headache is not dependent on histamine release: support for a direct nociceptive action of nitric oxide. Cephalalgia : an international journal of headache, 1994, Volume: 14, Issue:6 Topics: Analysis of Variance; Cross-Over Studies; Double-Blind Method; Headache; Hemodynamics; Histamine Rel	1994
Topical nitroglycerin therapy for anal fissures and ulcers. The New England journal of medicine, 1995, Oct-26, Volume: 333, Issue:17 Topics: Administration, Topical; Adult; Anus Diseases; Female; Fissure in Ano; Humans; Male; Nitroglycerin;	1995
Pain on injection of propofol: modification by nitroglycerin. Anesthesia and analgesia, 1993, Volume: 77, Issue:6 Topics: Ambulatory Surgical Procedures; Female; Genital Diseases, Female; Hand; Humans; Injections, Intraven	1993
Pain induces decrease of blood flow in the common carotid arteries in cluster headache attacks. Cephalalgia : an international journal of headache, 1993, Volume: 13, Issue:2 Topics: Adult; Aged; Blood Pressure; Carotid Artery, Common; Cerebrovascular Circulation; Cluster Headache;	1993
Crossover study of glyceryl trinitrate patches for controlling pain in women with severe dysmenorrhoea. BMJ (Clinical research ed.), 1996, Apr-06, Volume: 312, Issue:7035 Topics: Administration, Cutaneous; Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Dysmenorrhea;	1996
The application of EMLA and glyceryl trinitrate ointment prior to venepuncture. Anaesthesia and intensive care, 1996, Volume: 24, Issue:3 Topics: Adult; Anesthetics, Local; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations;	1996
Successful treatment of shoulder pain syndrome due to supraspinatus tendinitis with transdermal nitroglycerin. A double blind study. Pain, 1996, Volume: 66, Issue:1 Topics: Administration, Cutaneous; Adult; Analgesia; Double-Blind Method; Female; Humans; Male; Middle Aged;	1996
Studies on the response of nitroglycerin oral spray compared with sublingual tablets for angina pectoris patients with dry mouth. A multicenter trial. Arzneimittel-Forschung, 1997, Volume: 47, Issue:2 Topics: Administration, Sublingual; Aerosols; Angina Pectoris; Double-Blind Method; Electrocardiography; Exe	1997
Effects of topical nitroglycerin and intravenous lidocaine on propofol-induced pain on injection. Anesthesia and analgesia, 1997, Volume: 84, Issue:4 Topics: Administration, Topical; Adult; Aged; Anesthetics, Local; Double-Blind Method; Female; Humans; Injec	1997
Pain scoring--a method for assessing acute antianginal therapy comparison of the response to acute sublingual administration of an isosorbide dinitrate tablet, isosorbide dinitrate spray and nitroglycerin spray in unstable angina. Cardiology, 1998, Volume: 89, Issue:3 Topics: Administration, Inhalation; Administration, Oral; Administration, Sublingual; Adult; Aged; Aged, 80	1998
Increasing nitroglycerin release from patches enables circumvention of early nitrate tolerance. Cardiovascular drugs and therapy, 1998, Volume: 12, Issue:2 Topics: Adult; Blood Pressure; Coronary Disease; Electrocardiography; Exercise; Half-Life; Hemodynamics; Hum	1998
The addition of GTN to capsaicin cream reduces the discomfort associated with application of capsaicin alone. A volunteer study. Pain, 1998, Volume: 78, Issue:2 Topics: Capsaicin; Double-Blind Method; Drug Therapy, Combination; Humans; Nitroglycerin; Ointments; Pain; T	1998
The pharmacodynamics of sumatriptan in nitroglycerin-induced headache. Journal of clinical pharmacology, 1999, Volume: 39, Issue:1 Topics: Adult; Analysis of Variance; Area Under Curve; Brain; Cerebral Arteries; Electrocardiography; Headac	1999
Glyceryl trinitrate ointment for the treatment of chronic anal fissure: results of a placebo-controlled trial and long-term follow-up. Diseases of the colon and rectum, 1999, Volume: 42, Issue:8 Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Chronic Disease; Double-Blind Method; Femal	1999
Glyceryl trinitrate for chronic anal fissure--healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial. Diseases of the colon and rectum, 2000, Volume: 43, Issue:2 Topics: Adult; Anal Canal; Blood Flow Velocity; Chronic Disease; Double-Blind Method; Female; Fissure in Ano	2000
A randomized trial of glyceryl trinitrate ointment and nitroglycerin patch in healing of anal fissures. International journal of colorectal disease, 2000, Volume: 15, Issue:4 Topics: Administration, Cutaneous; Adult; Chronic Disease; Female; Fissure in Ano; Humans; Male; Middle Aged	2000
Nitroderm TTS band application for pain after hemorrhoidectomy. Diseases of the colon and rectum, 2001, Volume: 44, Issue:5 Topics: Administration, Cutaneous; Adult; Aged; Anal Canal; Female; Hemorrhoids; Humans; Male; Manometry; Mi	2001
Chemical colostomy irrigation with glyceryl trinitrate solution. Diseases of the colon and rectum, 2001, Volume: 44, Issue:9 Topics: Adult; Aged; Blood Pressure; Colostomy; Defecation; Female; Humans; Male; Middle Aged; Muscle, Smoot	2001
The addition of glyceryltrinitrate to capsaicin cream reduces the thermal allodynia associated with the application of capsaicin alone in humans. Neuroscience letters, 2002, Apr-19, Volume: 323, Issue:1 Topics: Capsaicin; Double-Blind Method; Drug Therapy, Combination; Humans; Nitroglycerin; Ointments; Pain; T	2002
Double-blind evaluation of transdermal nitroglycerine as adjuvant to oral morphine for cancer pain management. Journal of clinical anesthesia, 2002, Volume: 14, Issue:2 Topics: Administration, Cutaneous; Administration, Oral; Analgesics, Opioid; Double-Blind Method; Drug Syner	2002
[Chronic idiopathic anal pain syndrome]. Ugeskrift for laeger, 2002, Apr-29, Volume: 164, Issue:18 Topics: Adult; Anal Canal; Analgesics; Anus Diseases; Botulinum Toxins; Chronic Disease; Colostomy; Female;	2002
The use of glyceryl trinitrate ointment with EMLA cream for i.v. cannulation in children undergoing routine surgery. Anaesthesia and intensive care, 2002, Volume: 30, Issue:3 Topics: Administration, Topical; Adolescent; Anesthesia, Local; Catheterization, Peripheral; Child; Child, P	2002
Effect of new beta-adrenergic blocking agent, Atenolol (Tenormin), on pain frequency, trinitrin consumption, and exercise ability. British medical journal, 1975, Jul-26, Volume: 3, Issue:5977 Topics: Administration, Oral; Adrenergic beta-Antagonists; Angina Pectoris; Blood Pressure; Clinical Trials	1975
Buccal nitroglycerin decreases ischemic pain during coronary angioplasty: a double-blind, randomized, placebo-controlled study. American heart journal, 1990, Volume: 120, Issue:2 Topics: Administration, Buccal; Angioplasty, Balloon, Coronary; Coronary Disease; Double-Blind Method; Human	1990
Topical glyceryl trinitrate and eutectic mixture of local anaesthetics in children. A randomised controlled trial on choice of site and ease of venous cannulation. Anaesthesia, 1991, Volume: 46, Issue:10 Topics: Administration, Topical; Anesthetics, Local; Catheterization, Peripheral; Child; Child, Preschool; D	1991
Local application of EMLA and glyceryl trinitrate ointment before venepuncture. Anaesthesia, 1990, Volume: 45, Issue:1 Topics: Administration, Cutaneous; Adult; Aged; Anesthesia, Intravenous; Anesthesia, Local; Anesthetics, Loc	1990
Adenosine injection into the brachial artery produces ischaemia like pain or discomfort in the forearm. Cardiovascular research, 1988, Volume: 22, Issue:9 Topics: Adenosine; Adult; Brachial Artery; Forearm; Humans; Injections, Intra-Arterial; Ischemia; Male; Nitr	1988
Vitamin E in angina pectoris. Canadian Medical Association journal, 1974, Feb-16, Volume: 110, Issue:4 Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Nitroglyc	1974
Evaluation of lidoflazine as an anti-anginal drug. Cardiology, 1973, Volume: 58, Issue:4 Topics: Administration, Oral; Adult; Angina Pectoris; Clinical Trials as Topic; Coronary Angiography; Drug E	1973
A double-blind trial of vitamin E in angina pectoris. The American journal of clinical nutrition, 1974, Volume: 27, Issue:10 Topics: Angina Pectoris; Clinical Trials as Topic; Diarrhea; Evaluation Studies as Topic; Female; Gastrointe	1974
Nifedipine in angina pectoris. A multicentric clinical trial. Giornale italiano di cardiologia, 1974, Volume: 4, Issue:5 Topics: Adult; Aged; Analysis of Variance; Angina Pectoris; Clinical Trials as Topic; Dicarboxylic Acids; Dr	1974
The clinical effect of 4-(2'-nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine (BAY a 1040) on angina pectoris evaluated by sequential analysis. Arzneimittel-Forschung, 1972, Volume: 22, Issue:2 Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Dicarboxylic Acids; Electrocardiography; Exe	1972
Treatment of angina pectoris with dipyridamole: a double-blind study. Journal of the American Geriatrics Society, 1970, Volume: 18, Issue:3 Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Dipyridamole; Female; Humans; Locomotion; Male; Mid	1970
[Carbochromen in therapy of acute and chronic coronary insufficiency]. Arzneimittel-Forschung, 1970, Volume: 20 Topics: Acute Disease; Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease;	1970
A double-blind, double cross-over trial of prenylamine in angina pectoris. American heart journal, 1971, Volume: 82, Issue:1 Topics: Administration, Oral; Angina Pectoris; Blood Pressure; Electrocardiography; Esophageal Achalasia; He	1971

Article	Year
The gut microbiome modulates nitroglycerin-induced migraine-related hyperalgesia in mice. Cephalalgia : an international journal of headache, 2022, Volume: 42, Issue:6 Topics: Animals; Gastrointestinal Microbiome; Humans; Hyperalgesia; Mice; Migraine Disorders; Nitroglycerin;	2022
SCFA Treatment Alleviates Pathological Signs of Migraine and Related Intestinal Alterations in a Mouse Model of NTG-Induced Migraine. Cells, 2021, 10-14, Volume: 10, Issue:10 Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Down-Regulation; Fatty Acids,	2021
Cluster Headache. American family physician, 2022, 01-01, Volume: 105, Issue:1 Topics: Adult; Alcohol Drinking; Cluster Headache; Female; Humans; Male; Nitroglycerin; Oxygen; Pain; Physic	2022
The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target? Brain : a journal of neurology, 2022, 07-29, Volume: 145, Issue:7 Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Mice; Migraine Disorders; Nitrogly	2022
Transient receptor potential melastatin 8 is required for nitroglycerin- and calcitonin gene-related peptide-induced migraine-like pain behaviors in mice. Pain, 2022, 12-01, Volume: 163, Issue:12 Topics: Animals; Calcitonin Gene-Related Peptide; Cold Temperature; Genome-Wide Association Study; Mice; Mig	2022
Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine. International journal of molecular sciences, 2022, Apr-27, Volume: 23, Issue:9 Topics: Animals; Butyric Acid; Dietary Supplements; Disease Models, Animal; Fatty Acids, Volatile; Gastroint	2022
Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine. The journal of headache and pain, 2022, Jul-07, Volume: 23, Issue:1 Topics: Amides; Amidohydrolases; Animals; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Inflammati	2022
The effect of local cold compresses for nitroglycerin-induced headache: An observational pretest-posttest study. Nursing in critical care, 2023, Volume: 28, Issue:6 Topics: Blood Pressure; Headache; Humans; Nitroglycerin; Pain; Quality of Life	2023
Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior. Physiology & behavior, 2022, 11-01, Volume: 256 Topics: Animals; Disease Models, Animal; Formaldehyde; Hyperalgesia; Male; Migraine Disorders; Nitroglycerin	2022
A c-Fos activation map in nitroglycerin/levcromakalim-induced models of migraine. The journal of headache and pain, 2022, Sep-30, Volume: 23, Issue:1 Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Crom	2022
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. Nutrients, 2022, Nov-17, Volume: 14, Issue:22 Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc	2022
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. Nutrients, 2022, Nov-17, Volume: 14, Issue:22 Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc	2022
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. Nutrients, 2022, Nov-17, Volume: 14, Issue:22 Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc	2022
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. Nutrients, 2022, Nov-17, Volume: 14, Issue:22 Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc	2022
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. Nutrients, 2022, Nov-17, Volume: 14, Issue:22 Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc	2022
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. Nutrients, 2022, Nov-17, Volume: 14, Issue:22 Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc	2022
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. Nutrients, 2022, Nov-17, Volume: 14, Issue:22 Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc	2022
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. Nutrients, 2022, Nov-17, Volume: 14, Issue:22 Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc	2022
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. Nutrients, 2022, Nov-17, Volume: 14, Issue:22 Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc	2022
Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine. The journal of headache and pain, 2023, May-03, Volume: 24, Issue:1 Topics: Animals; Calcitonin Gene-Related Peptide; Cannabidiol; Disease Models, Animal; Hyperalgesia; Male; M	2023
Shaoyao Gancao decoction alleviates the central hyperalgesia of recurrent NTG-induced migraine in rats by regulating the NGF/TRPV1/COX-2 signal pathway. Journal of ethnopharmacology, 2023, Dec-05, Volume: 317 Topics: Animals; Calcitonin Gene-Related Peptide; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinas	2023
GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model. Neuroscience letters, 2023, 08-24, Volume: 812 Topics: Animals; Disease Models, Animal; Glucagon-Like Peptide-1 Receptor; Hyperalgesia; Interleukin-10; Lir	2023
Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response. Journal of ethnopharmacology, 2020, May-23, Volume: 254 Topics: Analgesics; Animals; Hyperalgesia; Male; Migraine Disorders; Nitric Oxide; Nitric Oxide Synthase Typ	2020
Physical exercise enhances vulnerability to migraine headache associated with CGRP up-expression in trigeminal nucleus caudalis of stressed rats. Neurological research, 2020, Volume: 42, Issue:11 Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Hyperalgesia;	2020
Use of Sublingual Nitrates for Management of Limb Ischemia Secondary to Inadvertent Intra-Arterial Buprenorphine/Naloxone (Suboxone®) Film Injection. Puerto Rico health sciences journal, 2020, Volume: 39, Issue:3 Topics: Administration, Sublingual; Adult; Angiography; Anticoagulants; Buprenorphine, Naloxone Drug Combina	2020
Does the duration of symptoms of anal fissure impact its response to conservative treatment? A prospective cohort study. International journal of surgery (London, England), 2017, Volume: 44 Topics: Acute Disease; Adolescent; Adult; Aged; Chronic Disease; Conservative Treatment; Constipation; Femal	2017
TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice. Brain : a journal of neurology, 2018, 08-01, Volume: 141, Issue:8 Topics: Aldehyde Dehydrogenase, Mitochondrial; Animals; Cell Body; Headache; Hyperalgesia; Male; Mice; Mice,	2018
Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing. The journal of headache and pain, 2018, Jul-13, Volume: 19, Issue:1 Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Fructose; Gene Expression; Male; M	2018
Botulinum toxin for treatment of Raynaud phenomenon in CREST syndrome. Dermatology online journal, 2018, Dec-15, Volume: 24, Issue:12 Topics: Acetylcholine Release Inhibitors; Administration, Topical; Aged; Botulinum Toxins; CREST Syndrome; D	2018
Arm Pain after Transradial Coronary Procedures. Cardiovascular revascularization medicine : including molecular interventions, 2019, Volume: 20, Issue:8 Topics: Arm; Catheterization; Coronary Angiography; Humans; Nitroglycerin; Pain; Radial Artery	2019
Anal fissure: diagnosis, management, and referral in primary care. The British journal of general practice : the journal of the Royal College of General Practitioners, 2019, Volume: 69, Issue:685 Topics: Administration, Topical; Botulinum Toxins, Type A; Conservative Treatment; Dietary Fiber; Fissure in	2019
Effect of Paeonia lactiflora, a traditional Chinese herb, on migraines based on clinical application and animal behavior analyses. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 118 Topics: Animals; Anxiety; Behavior, Animal; Calcitonin Gene-Related Peptide; Depression; Drugs, Chinese Herb	2019
Gut Microbiota Dysbiosis Enhances Migraine-Like Pain Via TNFα Upregulation. Molecular neurobiology, 2020, Volume: 57, Issue:1 Topics: Animals; Anti-Bacterial Agents; Dysbiosis; Gastrointestinal Microbiome; Gene Deletion; Male; Mice, I	2020
Impact of non-cardiovascular surgery on reactive hyperaemia and arterial endothelial function. Clinical and experimental pharmacology & physiology, 2013, Volume: 40, Issue:7 Topics: Aged; Aged, 80 and over; Blood Flow Velocity; Blood Pressure; Brachial Artery; Cardiovascular Diseas	2013
Correlation between algogenic effects of calcitonin-gene-related peptide (CGRP) and activation of trigeminal vascular system, in an in vivo experimental model of nitroglycerin-induced sensitization. European journal of pharmacology, 2014, Oct-05, Volume: 740 Topics: Animals; Brain; Calcitonin Gene-Related Peptide; Male; Nitric Oxide; Nitric Oxide Donors; Nitroglyce	2014
Pharmacological characterization of a novel gastrodin derivative as a potential anti-migraine agent. Fitoterapia, 2016, Volume: 109 Topics: Analgesics; Animals; Benzyl Alcohols; Calcitonin Gene-Related Peptide; Female; Glucosides; Male; Mic	2016
0.4% glyceryl trinitrate ointment: new drug. Not useful for anal fissures. Prescrire international, 2008, Volume: 17, Issue:94 Topics: Adult; Chronic Disease; Clinical Trials as Topic; Fissure in Ano; France; Humans; Nitroglycerin; Oin	2008
Role of central dopaminergic circuitry in pain processing and nitroglycerin-induced hyperalgesia. Brain research, 2008, Oct-31, Volume: 1238 Topics: Adrenergic Agents; Animals; Basal Ganglia; Denervation; Dopamine; Formaldehyde; Hyperalgesia; Image	2008
[The role of glyceryl trinitrate in the treatment of anal fissure]. Magyar sebeszet, 2008, Volume: 61, Issue:4 Topics: Acute Disease; Adult; Anal Canal; Chronic Disease; Diagnosis, Differential; Female; Fissure in Ano;	2008
Microcirculatory effects of topical glyceryl trinitrate on the Achilles tendon microcirculation in patients with previous Achilles tendon rupture. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2010, Volume: 18, Issue:7 Topics: Achilles Tendon; Administration, Topical; Adult; Aged; Blood Flow Velocity; Blood Gas Analysis; Huma	2010
Assessment of endothelial function in patients with fibromyalgia--cardiac ultrasound study. Clinical rheumatology, 2011, Volume: 30, Issue:5 Topics: Brachial Artery; Case-Control Studies; Echocardiography; Endothelium, Vascular; Female; Fibromyalgia	2011
Comparison between lidocaine and glyceryl trinitrate ointment for perianal-intrarectal local anesthesia before transrectal ultrasonography-guided prostate biopsy: a placebo-controlled trial. Urology, 2011, Volume: 77, Issue:4 Topics: Anesthesia, Local; Anesthetics, Local; Biopsy, Needle; Gels; Humans; Lidocaine; Male; Nitroglycerin;	2011
Acute leg pain due to iliac artery spasm during coronary angiography: an unusual consequence of an uncommon problem. Angiology, 2011, Volume: 62, Issue:4 Topics: Acute Disease; Aged; Analgesics, Opioid; Coronary Angiography; Fentanyl; Humans; Iliac Artery; Leg;	2011
Nitroglycerin ointment (Rectiv) for anal fissure. The Medical letter on drugs and therapeutics, 2012, Mar-19, Volume: 54, Issue:1386 Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Ointments; Pain; Va	2012
St. John's wort relieves pain in an animal model of migraine. European journal of pain (London, England), 2013, Volume: 17, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Blotting, Western; Cold Temperat	2013
Evaluation of a spasmolytic cocktail to prevent radial artery spasm during coronary procedures. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2003, Volume: 58, Issue:3 Topics: Aged; Angina Pectoris; Angioplasty; Coronary Angiography; Drug Therapy, Combination; Female; Humans;	2003
Nitroglycerin induces hyperalgesia in rats--a time-course study. European journal of pharmacology, 2003, Mar-19, Volume: 464, Issue:2-3 Topics: Animals; Behavior, Animal; Formaldehyde; Hyperalgesia; Male; Nitroglycerin; Pain; Pain Measurement;	2003
Alternative application site of transdermal nitroglycerin and the reduction of pain on propofol injection. European journal of anaesthesiology, 2003, Volume: 20, Issue:2 Topics: Administration, Cutaneous; Anesthetics, Intravenous; Female; Humans; Male; Middle Aged; Nitroglyceri	2003
[Therapy of stenocardiac pains with nitroglycerin]. Nederlands tijdschrift voor geneeskunde, 1960, Jan-09, Volume: 104 Topics: Angina Pectoris; Nitrites; Nitroglycerin; Pain	1960
[ANALYSIS OF PAINFUL CONDITIONS OF THE ANTERIOR CHEST WALL AFTER MYOCARDIAL INFARCT]. Casopis lekaru ceskych, 1963, Sep-13, Volume: 102 Topics: Angina Pectoris; Cervical Vertebrae; Diagnosis, Differential; Humans; Myocardial Infarction; Nitrogl	1963
ANGINA PECTORIS WITH COEXISTING SKELETAL CHEST PAIN. American heart journal, 1963, Volume: 66 Topics: Angina Pectoris; Chest Pain; Electrocardiography; Geriatrics; Humans; Nitroglycerin; Pain; Physical	1963
[COURSE OF ACTION IN PRECORDIALGIA]. Belgisch tijdschrift voor geneeskunde, 1964, Jan-15, Volume: 20 Topics: Abdomen; Angina Pectoris; Diagnosis, Differential; Electrocardiography; Gastroenterology; Heart Dise	1964
[ON PROCTALGIA]. Vestnik khirurgii imeni I. I. Grekova, 1964, Volume: 92 Topics: Drug Therapy; Humans; Nitroglycerin; Pain; Rectal Diseases; Rectum	1964
NECK, SHOULDER AND ARM PAIN. Postgraduate medicine, 1964, Volume: 36 Topics: Arm; Arm Injuries; Diagnosis, Differential; Heart Diseases; Humans; Joint Diseases; Lung Neoplasms;	1964
Sublingual glyceryl trinitrate as prehospital treatment for hypertension in Irukandji syndrome. The Medical journal of Australia, 2004, May-03, Volume: 180, Issue:9 Topics: Animals; Bites and Stings; Cnidarian Venoms; Emergency Medical Services; Humans; Hypertension; Magne	2004
Sublingual glyceryl trinitrate as prehospital treatment for hypertension in Irukandji syndrome. The Medical journal of Australia, 2004, May-03, Volume: 180, Issue:9 Topics: Animals; Bites and Stings; Chest Pain; Cnidarian Venoms; Emergency Medical Services; Humans; Hyperte	2004
Nitroglycerin spray rapidly improves pain in a patient with chronic painful diabetic neuropathy. Diabetic medicine : a journal of the British Diabetic Association, 2004, Volume: 21, Issue:9 Topics: Administration, Topical; Adult; Chronic Disease; Diabetic Neuropathies; Humans; Male; Nitric Oxide D	2004
Involvement of nitric oxide in clonidine-induced spinal analgesia. Drug metabolism and drug interactions, 2005, Volume: 21, Issue:1 Topics: Acute Disease; Analgesia; Analgesics; Animals; Arginine; Clonidine; Injections, Spinal; Male; Methyl	2005
Cerebroventricular injection of clonidine causes analgesia mediated by a nitrogen pathway. Drug metabolism and drug interactions, 2005, Volume: 21, Issue:1 Topics: Acute Disease; Analgesia; Analgesics; Animals; Arginine; Cerebral Ventricles; Clonidine; Injections;	2005
Failure of magnesium in treatment of Irukandji syndrome. Anaesthesia and intensive care, 2005, Volume: 33, Issue:4 Topics: Adult; Analgesics; Analgesics, Opioid; Bites and Stings; Bronchodilator Agents; Cnidarian Venoms; Ep	2005
Sequential treatment for proctalgia fugax. Mid-term follow-up. Revista espanola de enfermedades digestivas, 2005, Volume: 97, Issue:7 Topics: Acute Disease; Adult; Anal Canal; Anti-Anxiety Agents; Anus Diseases; Baths; Benzodiazepines; Endoso	2005
The need to reduce patient discomfort during transrectal ultrasonography-guided prostate biopsy: what do we know? BJU international, 2006, Volume: 97, Issue:1 Topics: Analgesics; Humans; Male; Nitroglycerin; Pain; Ultrasound, High-Intensity Focused, Transrectal	2006
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test. European journal of pharmacology, 2006, Mar-18, Volume: 534, Issue:1-3 Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid An	2006
0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain: a viewpoint by Richard Nelson. Drugs, 2006, Volume: 66, Issue:3 Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitric Oxide Donors; Nitroglycerin	2006
0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain : a viewpoint by Jonathan N. Lund. Drugs, 2006, Volume: 66, Issue:3 Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Meta-Analysis as Topic; Nitric Oxi	2006
0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain : a viewpoint by Laurence R. Sands. Drugs, 2006, Volume: 66, Issue:3 Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitric Oxide Donors; Nitroglycerin	2006
[The effects of combination of two lornoxicam doses and nitroglycerine on acute pain in rats]. Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2005, Volume: 17, Issue:4 Topics: Acute Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combinati	2005
Re: A randomized controlled trial of topical glyceryl trinitrate before transrectal ultrasonography-guided biopsy of the prostate. BJU international, 2008, Volume: 101, Issue:1 Topics: Administration, Topical; Anesthetics, Local; Biopsy, Needle; Humans; Male; Nerve Block; Nitroglyceri	2008
Role of calcitonin gene-related peptide and substance P in different models of pain. Cephalalgia : an international journal of headache, 2008, Volume: 28, Issue:2 Topics: Animals; Calcitonin Gene-Related Peptide; Central Nervous System; Formaldehyde; Hyperalgesia; Immuno	2008
Drug therapy today: when your patient has chest pain... RN, 1980, Volume: 43, Issue:12 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angina Pectoris; Angina Pectoris, Variant	1980
Complete heart block after sublingual nitroglycerin. Chest, 1983, Volume: 84, Issue:1 Topics: Administration, Oral; Electrocardiography; Heart Block; Humans; Hypotension; Lidocaine; Male; Middle	1983
Provocative ergonovine testing in patients without obstructive coronary disease. Catheterization and cardiovascular diagnosis, 1983, Volume: 9, Issue:3 Topics: Coronary Vasospasm; Electrocardiography; Ergonovine; Female; Humans; Male; Middle Aged; Nitroglyceri	1983
Oesophageal chest pain: a point of view. Gut, 1984, Volume: 25, Issue:1 Topics: Calcium Channel Blockers; Diagnosis, Differential; Esophageal Diseases; Heart Diseases; Humans; Hydr	1984
Nitradisc in unstable angina pectoris and continuing chest pain after acute myocardial infarct. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1984, Feb-11, Volume: 65, Issue:6 Topics: Angina Pectoris; Angina, Unstable; Humans; Myocardial Infarction; Nitroglycerin; Pain; Thorax	1984
Experience with ergonovine provocative testing for coronary arterial spasm. Chest, 1981, Volume: 79, Issue:6 Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Arterial Occlusive Diseases; Cardiac Catheterizati	1981
[The immediate treatment of acute myocardial infarct]. Medizinische Klinik, 1981, Mar-27, Volume: 76, Issue:7 Topics: Acute Disease; Arrhythmias, Cardiac; First Aid; Furosemide; Hemodynamics; Humans; Isosorbide Dinitra	1981
Esophageal Manometry in Patients with Chest Pain and Normal Coronary Arteriogram. The American journal of gastroenterology, 1981, Volume: 75, Issue:2 Topics: Adult; Aged; Angina Pectoris; Angiocardiography; Diagnosis, Differential; Esophageal Achalasia; Esop	1981
Coronary arterial spasm in single coronary artery. Circulation, 1981, Volume: 64, Issue:6 Topics: Coronary Angiography; Coronary Vasospasm; Diltiazem; Electrocardiography; Ergonovine; Humans; Isosor	1981
Intravenous dipyridamole combined with isometric handgrip for near maximal acute increase in coronary flow in patients with coronary artery disease. The American journal of cardiology, 1981, Volume: 48, Issue:6 Topics: Acute Disease; Constriction, Pathologic; Coronary Angiography; Coronary Circulation; Coronary Diseas	1981
A study of the implicit criteria used in diagnosing chest pain. Medical decision making : an international journal of the Society for Medical Decision Making, 1982,Winter, Volume: 2, Issue:4 Topics: Angina Pectoris; Coronary Angiography; Coronary Disease; Humans; Nitroglycerin; Pain; Risk; Thorax	1982
Treatment of benign anal disease with topical nitroglycerin. Diseases of the colon and rectum, 1995, Volume: 38, Issue:5 Topics: Administration, Topical; Adult; Anal Canal; Defecation; Female; Fissure in Ano; Follow-Up Studies; H	1995
Diabetic neuropathy and possible treatment. Journal of the American Geriatrics Society, 1994, Volume: 42, Issue:5 Topics: Aged; Aged, 80 and over; Diabetic Neuropathies; Female; Humans; Male; Middle Aged; Nitroglycerin; Oi	1994
Right-lateralised central processing for pain of nitroglycerin-induced cluster headache. Pain, 1996, Volume: 67, Issue:1 Topics: Adult; Brain; Cerebrovascular Circulation; Cluster Headache; Female; Functional Laterality; Gyrus Ci	1996
[Effect of sublingual nitroglycerin on pain following ERCP]. Ugeskrift for laeger, 1997, Mar-24, Volume: 159, Issue:13 Topics: Administration, Sublingual; Analgesics; Cholangiopancreatography, Endoscopic Retrograde; Female; Hum	1997
Postural hypotension from topical glyceryl trinitrate ointment for anal pain. Journal of pain and symptom management, 1997, Volume: 14, Issue:5 Topics: Administration, Rectal; Adult; Anal Canal; Humans; Hypotension, Orthostatic; Male; Nitroglycerin; Oi	1997
[Erroneous intravenous injection of adrenaline]. Deutsche medizinische Wochenschrift (1946), 1998, May-29, Volume: 123, Issue:22 Topics: Adult; Analgesics, Opioid; Diuretics; Epinephrine; Furosemide; Humans; Hypotension; Injections, Intr	1998
Topical nitroglycerin and pain in purpura fulminans. The Journal of pediatrics, 1999, Volume: 134, Issue:5 Topics: Administration, Topical; Adolescent; Analgesics; Female; Humans; IgA Vasculitis; Nitroglycerin; Pain	1999
Reciprocal circuits involved in nitroglycerin-induced neuronal activation of autonomic regions and pain pathways: a double immunolabeling and tract-tracing study. Brain research, 1999, Sep-25, Volume: 842, Issue:2 Topics: Animals; Autonomic Nervous System; Axonal Transport; Locus Coeruleus; Male; Mesencephalon; Neural Pa	1999
Chronic idiopathic anal pain: analysis of ultrasonography, pathology, and treatment. Diseases of the colon and rectum, 2001, Volume: 44, Issue:5 Topics: Adult; Anal Canal; Analgesics; Anti-Dyskinesia Agents; Anus Diseases; Botulinum Toxins; Chronic Dise	2001
Angina pectoris. Diagnosis and treatment. Postgraduate medicine, 1976, Volume: 59, Issue:5 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Coronary Disease; Diagnosis, Differential; Digitalis G	1976
Angina pectoris: current approach to treatment. Drugs, 1979, Volume: 18, Issue:2 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Coronary Artery Bypass; Humans; Nitroglycerin; Pain; P	1979
Mechanism of rest and nocturnal angina: observations during continuous hemodynamic and electrocardiographic monitoring. Circulation, 1979, Volume: 59, Issue:5 Topics: Aged; Angina Pectoris; Blood Pressure; Cardiac Output; Electrocardiography; Female; Heart Conduction	1979
Recurrent chest pain with transient ST-segment elevation and acute myocardial infarction in a patient with normal coronary arteries. Canadian Medical Association journal, 1979, Aug-04, Volume: 121, Issue:3 Topics: Adult; Aspartate Aminotransferases; Coronary Angiography; Creatine Kinase; Electrocardiography; Huma	1979
Diagnosis of angina pectoris. Scottish medical journal, 1977, Volume: 22, Issue:1 Topics: Angina Pectoris; Coronary Angiography; Coronary Disease; Diagnosis, Differential; Electrocardiograph	1977
Esophageal manometrics in patients with angina-like chest pain. The American journal of digestive diseases, 1977, Volume: 22, Issue:4 Topics: Adult; Aged; Angina Pectoris; Antacids; Diagnosis, Differential; Esophageal Diseases; Esophagogastri	1977
Role of sublingual nitroglycerin in patients with acute myocardial infarction. British heart journal, 1975, Volume: 37, Issue:4 Topics: Acute Disease; Blood Pressure; Cardiac Output; Depression, Chemical; Female; Heart Rate; Humans; Mal	1975
[Clinical characteristics of angina pectoris in relation to disease of the coronary arteries]. Kardiologiia, 1975, Volume: 15, Issue:5 Topics: Adult; Aged; Angina Pectoris; Angiocardiography; Coronary Angiography; Coronary Disease; Eating; Hum	1975
Prinzmetal angina. Normal arteries and multifocal electrocardiographic changes. JAMA, 1976, Jan-05, Volume: 235, Issue:1 Topics: Adult; Angina Pectoris; Angiography; Cardiac Catheterization; Coronary Angiography; Electrocardiogra	1976
An enzyme mechanism in explanation of pain in angina pectoris. Recent advances in studies on cardiac structure and metabolism, 1975, Volume: 10 Topics: Angina Pectoris; Animals; Bees; Enzyme Activation; Epinephrine; Humans; Nitroglycerin; Norepinephrin	1975
Chest pain-the diagnostic dilemma. Journal of the Medical Association of Georgia, 1976, Volume: 65, Issue:10 Topics: Coronary Disease; Exercise Test; Humans; Nitroglycerin; Pain; Thorax	1976
[Pancreatic pain: a clinical-experimental study]. Zeitschrift fur Gastroenterologie, 1976, Volume: 14, Issue:7 Topics: Endoscopy; Humans; Nitroglycerin; Pain; Pancreatic Diseases; Vascular Diseases	1976
MRI of intracranial arteries in nitroglycerin induced cluster headache attacks. Headache, 1992, Volume: 32, Issue:10 Topics: Cerebral Arteries; Cluster Headache; Humans; Magnetic Resonance Imaging; Nitroglycerin; Pain; Vasoco	1992
[Treatment of pain in suspected acute myocardial infarction--current views on therapeutical alternatives]. Lakartidningen, 1988, Feb-03, Volume: 85, Issue:5 Topics: Adrenergic beta-Antagonists; Analgesia; Analgesics, Opioid; Humans; Myocardial Infarction; Nitroglyc	1988
Nursing management of the patient with acute myocardial infarction. Cardiovascular clinics, 1986, Volume: 16, Issue:3 Topics: Angioplasty, Balloon; Coronary Care Units; Early Ambulation; Emergency Medical Services; Fibrinolyti	1986
[Disorders of esophageal motility as a cause of retrosternal pain]. Terapevticheskii arkhiv, 1986, Volume: 58, Issue:2 Topics: Adult; Diagnosis, Differential; Esophageal Diseases; Esophagitis, Peptic; Female; Gastrointestinal M	1986
Local percutaneous nitroglycerine therapy for "burning feet" syndrome. The Medical journal of Australia, 1987, Jan-05, Volume: 146, Issue:1 Topics: Administration, Cutaneous; Aged; Humans; Ischemia; Leg; Male; Nitroglycerin; Pain	1987
A novel aid for the relief of gall-stone pain. Tropical and geographical medicine, 1988, Volume: 40, Issue:1 Topics: Aerosols; Cholelithiasis; Drug Stability; Humans; Nitroglycerin; Pain; Tropical Climate	1988
Therapy for proctodynia. The Medical journal of Australia, 1985, Nov-25, Volume: 143, Issue:11 Topics: Anal Canal; Humans; Male; Nitroglycerin; Pain	1985
The variant form of angina: diagnostic and therapeutic implications. American heart journal, 1974, Volume: 87, Issue:3 Topics: Adult; Angina Pectoris; Angiocardiography; Cineangiography; Coronary Artery Bypass; Diagnosis, Diffe	1974
Diagnosis of angina pectoris at the present time. The Medical clinics of North America, 1974, Volume: 58, Issue:2 Topics: Angina Pectoris; Cholesterol; Coronary Angiography; Coronary Circulation; Diagnosis, Differential; E	1974
[Modern diagnosis of ischemic heart disease (based on the data from clinical and angiographic comparison)]. Kardiologiia, 1974, Volume: 14, Issue:2 Topics: Adult; Angina Pectoris; Angiocardiography; Arteriosclerosis; Coronary Angiography; Coronary Disease;	1974
The diagnostic significance of anginal symptoms. JAMA, 1974, Aug-26, Volume: 229, Issue:9 Topics: Adult; Angina Pectoris; Cardiac Catheterization; Coronary Angiography; Electrocardiography; Exercise	1974
[Current problems in diagnosis and treatment of angina pectoris]. Medicina interna, 1972, Volume: 24, Issue:8 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angiography; Anticoagulants; Benzofurans; Coronary Ang	1972
[Angina pectoris, its diagnosis and treatment]. Therapeutische Umschau. Revue therapeutique, 1972, Volume: 29, Issue:2 Topics: Angina Pectoris; Angiography; Diagnosis, Differential; Electrocardiography; Humans; Nitroglycerin; P	1972
Diagnostic potential of amyl nitrite and nitroglycerin. JAMA, 1973, Feb-19, Volume: 223, Issue:8 Topics: Amyl Nitrite; Blood Pressure; Coronary Disease; Electrocardiography; False Negative Reactions; False	1973
Circulatory changes associated with spontaneous angina pectoris. Transactions of the Association of American Physicians, 1966, Volume: 79 Topics: Adult; Aged; Angina Pectoris; Blood Pressure Determination; Bundle-Branch Block; Digitalis Glycoside	1966
Withdrawal symptoms in workers exposed to nitroglycerine. British journal of industrial medicine, 1968, Volume: 25, Issue:2 Topics: Adult; Angina Pectoris; Chemical Industry; Death, Sudden; Diagnosis, Differential; Environmental Exp	1968
[Metabolic therapeutic possibilities of ischemic heart disease]. Medizinische Klinik, 1967, Oct-20, Volume: 62, Issue:42 Topics: Angina Pectoris; Aspartic Acid; Coronary Disease; Electrocardiography; Female; Humans; Hypertension;	1967
Nitrolglycerin as a provocative agent in cluster headache. Archives of neurology, 1968, Volume: 19, Issue:5 Topics: Adult; Blood Pressure; Headache; Humans; Male; Middle Aged; Nitroglycerin; Pain; Parasympatholytics;	1968
Precordial pain in an epileptic relic by dilantin. The Johns Hopkins medical journal, 1969, Volume: 124, Issue:1 Topics: Angina Pectoris; Diagnosis, Differential; Electrocardiography; Epilepsy; Female; Humans; Middle Aged	1969
A new observation on human intraductal pancreatic pressure. Surgery, gynecology & obstetrics, 1970, Volume: 130, Issue:2 Topics: Bethanechol Compounds; Catheterization; Cholecystokinin; Contrast Media; Humans; Injections, Intrave	1970
[Therapy of coronary insufficiency with carbochromen]. Arzneimittel-Forschung, 1970, Volume: 20 Topics: Acute Disease; Adult; Aged; Angina Pectoris; Blood Circulation; Blood Pressure; Chronic Disease; Cor	1970
Is history alone sufficient for the diagnosis of coronary artery disease? Advances in cardiopulmonary diseases, 1966, Volume: 3 Topics: Age Factors; Angina Pectoris; Chronic Disease; Coronary Disease; Electrocardiography; Emotions; Exer	1966
[What is reliable in the therapy of coronary disease?]. Der Internist, 1970, Volume: 11, Issue:12 Topics: Aminophylline; Amyl Nitrite; Angina Pectoris; Blood Pressure; Cardiac Glycosides; Coronary Disease;	1970

nitroglycerin and Pain