niacin and Obesity
niacin has been researched along with Obesity in 65 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " The goal of this study was to determine the effect of niacin administration on serum total- and phosphorylated fetuin-A (phosphofetuin-A) concentrations in individuals with MetS and correlate with changes in serum lipids, insulin sensitivity, and markers of inflammation." | 9.14 | Extended-release niacin decreases serum fetuin-A concentrations in individuals with metabolic syndrome. ( Grandjean, PW; Huang, EY; Kaushik, SV; Kim, T; Mahurin, AJ; Mathews, ST; Plaisance, EP, 2009) |
| "The efficacy of optimal doses of highly bioavailable (-)-hydroxycitric acid (HCA-SX) alone and in combination with niacin-bound chromium (NBC) and a standardized Gymnema sylvestre extract (GSE) on weight loss in moderately obese subjects was evaluated by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and excretion of urinary fat metabolites." | 9.11 | Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. ( Bagchi, D; Bagchi, M; Dey, DK; Preuss, HG; Rao, CV; Satyanarayana, S, 2004) |
| "We report the case of a 63-year-old obese man with a rapid-onset of widespread acanthosis nigricans (AN) in the setting of having recently initiated treatment with niacin for dyslipidemia." | 8.87 | Acanthosis nigricans in the setting of niacin therapy. ( Defelice, T; Hartman, R; Meehan, S; Sanchez, M; Tzu, J, 2011) |
| "Our purpose was to characterize changes in paraoxonase 1 (PON1) activity and concentration after single aerobic exercise sessions conducted before and after 6 weeks of niacin therapy in men with metabolic syndrome (MetS)." | 7.81 | Paraoxonase responses to exercise and niacin therapy in men with metabolic syndrome. ( Grandjean, PW; Mahurin, AJ; Mestek, ML; Moncada-Jimenez, J; Plaisance, EP; Taylor, JK, 2015) |
| "The widely used lipid-lowering drug niacin is reported to induce hyperglycemia during chronic and high-dose treatments, but the mechanism is poorly understood." | 7.81 | Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets. ( Boucher, BJ; Chen, L; Cheng, Q; Leung, PS; Li, SY; So, WY, 2015) |
| "To investigate nicotinamide's action on glucose metabolism, and the association between niacin consumption and obesity prevalence." | 7.76 | Chronic niacin overload may be involved in the increased prevalence of obesity in US children. ( Bian, FN; Guo, M; Li, D; Liu, QG; Luo, N; Sun, WP; Zhao, ZG; Zhou, SS; Zhou, YM, 2010) |
| " We studied lean (n = 6) and overweight and obese (n = 5) subjects during continuous feeding on two occasions: during intravenous infusion of niacin (2." | 5.16 | Intravenous niacin acutely improves the efficiency of dietary fat storage in lean and obese humans. ( Miles, JM; Nelson, RH; Smailovic, A; Vlazny, D, 2012) |
| " The goal of this study was to determine the effect of niacin administration on serum total- and phosphorylated fetuin-A (phosphofetuin-A) concentrations in individuals with MetS and correlate with changes in serum lipids, insulin sensitivity, and markers of inflammation." | 5.14 | Extended-release niacin decreases serum fetuin-A concentrations in individuals with metabolic syndrome. ( Grandjean, PW; Huang, EY; Kaushik, SV; Kim, T; Mahurin, AJ; Mathews, ST; Plaisance, EP, 2009) |
| "The efficacy of optimal doses of highly bioavailable (-)-hydroxycitric acid (HCA-SX) alone and in combination with niacin-bound chromium (NBC) and a standardized Gymnema sylvestre extract (GSE) on weight loss in moderately obese subjects was evaluated by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and excretion of urinary fat metabolites." | 5.11 | Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. ( Bagchi, D; Bagchi, M; Dey, DK; Preuss, HG; Rao, CV; Satyanarayana, S, 2004) |
| "We report the case of a 63-year-old obese man with a rapid-onset of widespread acanthosis nigricans (AN) in the setting of having recently initiated treatment with niacin for dyslipidemia." | 4.87 | Acanthosis nigricans in the setting of niacin therapy. ( Defelice, T; Hartman, R; Meehan, S; Sanchez, M; Tzu, J, 2011) |
| "Our purpose was to characterize changes in paraoxonase 1 (PON1) activity and concentration after single aerobic exercise sessions conducted before and after 6 weeks of niacin therapy in men with metabolic syndrome (MetS)." | 3.81 | Paraoxonase responses to exercise and niacin therapy in men with metabolic syndrome. ( Grandjean, PW; Mahurin, AJ; Mestek, ML; Moncada-Jimenez, J; Plaisance, EP; Taylor, JK, 2015) |
| "The widely used lipid-lowering drug niacin is reported to induce hyperglycemia during chronic and high-dose treatments, but the mechanism is poorly understood." | 3.81 | Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets. ( Boucher, BJ; Chen, L; Cheng, Q; Leung, PS; Li, SY; So, WY, 2015) |
| "To investigate nicotinamide's action on glucose metabolism, and the association between niacin consumption and obesity prevalence." | 3.76 | Chronic niacin overload may be involved in the increased prevalence of obesity in US children. ( Bian, FN; Guo, M; Li, D; Liu, QG; Luo, N; Sun, WP; Zhao, ZG; Zhou, SS; Zhou, YM, 2010) |
| "The prevalences of diabetes and adult obesity were highly correlated with per capita consumption of niacin, thiamin and riboflavin with a 26-and 10-year lag, respectively (R2 = 0." | 3.76 | B-vitamin consumption and the prevalence of diabetes and obesity among the US adults: population based ecological study. ( Li, D; Liu, QG; Sun, WP; Zhou, SS; Zhou, YM, 2010) |
| " We conclude that dosage levels, timing of administration, subject compliance and bioavailability of HCA-SX significantly affect results and that when taken as directed, HCA-SX is a highly effective adjunct to healthy weight control." | 2.71 | Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control. ( Bagchi, D; Bagchi, M; Bramble, JD; Garis, RI; Preuss, HG; Rao, CV; Satyanarayana, S, 2005) |
| " A range of dosing regimens was analyzed and predictions made for optimizing NiAc delivery to minimize FFA exposure." | 2.55 | Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments. ( Almquist, J; Andersson, R; Chappel, MJ; Evans, ND; Gabrielsson, J; Jirstrand, M; Kroon, T; Oakes, ND, 2017) |
| "Hyperlipidemia is common in dogs, and can be either primary or secondary to other diseases." | 2.46 | Lipid metabolism and hyperlipidemia in dogs. ( Steiner, JM; Xenoulis, PG, 2010) |
| "Patients with NIDDM are unable to increase their glucose oxidation normally in response to insulin to meet the energy demands of the body." | 2.38 | Insulin action and substrate competition. ( Ferrannini, E; Groop, LC, 1993) |
| "Overweight and obesity have become important nutrition and health problems of women aged 18−49 years in China." | 1.72 | Dietary Micronutrient Status and Relation between Micronutrient Intakes and Overweight and Obesity among Non-Pregnant and Non-Lactating Women Aged 18 to 49 in China. ( Cai, S; Cheng, X; Fang, H; Guo, Q; Ju, L; Li, S; Piao, W; Wei, X; Xu, X; Yu, D; Zhao, L, 2022) |
| "Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world." | 1.56 | Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet. ( Cao, Z; Lai, X; Shi, Y; Ye, L; Zhou, N, 2020) |
| "Niacin treatment was started from week 5 until the end of the study." | 1.56 | Niacin increases diet-induced hepatic steatosis in B6129 mice. ( Fang, H; Graff, EC; Judd, RL; Li, Z; McCafferty, KJ, 2020) |
| " Our aim was to find a rational NiAc dosing regimen that preserves FFA lowering, sufficient to reverse nonadipose tissue lipid accumulation and improve metabolic control, in obese Zucker rats." | 1.46 | Nicotinic acid timed to feeding reverses tissue lipid accumulation and improves glucose control in obese Zucker rats[S]. ( Baccega, T; Gabrielsson, J; Kroon, T; Oakes, ND; Olsén, A, 2017) |
| " To illustrate the application of the stochastic differential mixed effects model, two pharmacokinetic models are considered." | 1.42 | Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats. ( Ahlström, C; Almquist, J; Gabrielsson, J; Jirstrand, M; Leander, J, 2015) |
| " FFA lowering was assessed in male Sprague Dawley (lean) and obese Zucker rats (obese) in response to a 5 h NiAc infusion, in either NiAc-naïve animals or after 5 days of continuous (24 h/day) or intermittent (12 h/day) NiAc dosing (via implantable, programmable minipump)." | 1.42 | Dosing profile profoundly influences nicotinic acid's ability to improve metabolic control in rats. ( Gabrielsson, J; Kjellstedt, A; Kroon, T; Oakes, ND; Thalén, P, 2015) |
| "Niacin has recently been shown to improve endothelial function and vascular regeneration, independent of correcting dyslipidemia, in rodent models of vascular injury and metabolic disease." | 1.40 | Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity. ( Borradaile, NM; Chan, P; Hughes-Large, JM; Pang, DK; Robson, DL; Toma, J, 2014) |
| "High-fat diet induced hyperlipidemia and obesity in immature rats." | 1.39 | [Relationship of ox-LDL/LOX-1 and vascular endothelial dysfunction of diet-induced obese immature rats and nicotinic acid's intervention outcomes]. ( Han, B; Niu, N; Sun, SZ; Wang, Y, 2013) |
| "Dyslipidemia is frequently found in association with obesity." | 1.37 | Obesity and dyslipidemia. ( Repas, T, 2011) |
| "The incidence of colon cancer is high in many developed nations, especially New Zealand." | 1.32 | Epigenetic events and protection from colon cancer in New Zealand. ( Ferguson, LR; Karunasinghe, N; Philpott, M, 2004) |
| "Acanthosis nigricans was first reported in 1890 as a cutaneous sign of internal malignancy." | 1.29 | Acanthosis nigricans--decreased extracellular matrix viscosity: cancer, obesity, diabetes, corticosteroids, somatotrophin. ( Stone, OJ, 1993) |
Research
Studies (65)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (10.77) | 18.7374 |
| 1990's | 6 (9.23) | 18.2507 |
| 2000's | 15 (23.08) | 29.6817 |
| 2010's | 33 (50.77) | 24.3611 |
| 2020's | 4 (6.15) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Singh, LR | 1 |
| Kumar, A | 1 |
| Upadhyay, A | 1 |
| Gupta, S | 1 |
| Palanati, GR | 1 |
| Sikka, K | 1 |
| Siddiqi, MI | 1 |
| Yadav, PN | 1 |
| Sashidhara, KV | 1 |
| Ju, L | 1 |
| Wei, X | 1 |
| Yu, D | 1 |
| Fang, H | 3 |
| Cheng, X | 1 |
| Piao, W | 1 |
| Guo, Q | 1 |
| Xu, X | 1 |
| Li, S | 1 |
| Cai, S | 1 |
| Zhao, L | 1 |
| Zhang, X | 1 |
| Zhu, B | 1 |
| Lin, P | 1 |
| Liu, X | 1 |
| Gao, J | 1 |
| Yin, D | 1 |
| Zeng, J | 1 |
| Liao, B | 1 |
| Kang, Z | 1 |
| Ye, L | 1 |
| Cao, Z | 1 |
| Lai, X | 1 |
| Shi, Y | 1 |
| Zhou, N | 1 |
| Li, Z | 1 |
| Graff, EC | 2 |
| McCafferty, KJ | 1 |
| Judd, RL | 2 |
| Zhang, L | 1 |
| Cordeiro, LS | 1 |
| Liu, J | 1 |
| Ma, Y | 1 |
| Kim, EJ | 1 |
| Lim, SY | 1 |
| Lee, HJ | 1 |
| Lee, JY | 1 |
| Choi, S | 1 |
| Kim, SY | 1 |
| Kim, JM | 1 |
| Shin, IS | 1 |
| Yoon, JS | 1 |
| Yang, SJ | 1 |
| Kim, SW | 1 |
| Fangmann, D | 1 |
| Theismann, EM | 1 |
| Türk, K | 1 |
| Schulte, DM | 1 |
| Relling, I | 1 |
| Hartmann, K | 1 |
| Keppler, JK | 1 |
| Knipp, JR | 1 |
| Rehman, A | 1 |
| Heinsen, FA | 1 |
| Franke, A | 1 |
| Lenk, L | 1 |
| Freitag-Wolf, S | 1 |
| Appel, E | 1 |
| Gorb, S | 1 |
| Brenner, C | 1 |
| Seegert, D | 1 |
| Waetzig, GH | 1 |
| Rosenstiel, P | 1 |
| Schreiber, S | 1 |
| Schwarz, K | 1 |
| Laudes, M | 1 |
| Mandrika, I | 1 |
| Tilgase, A | 1 |
| Petrovska, R | 1 |
| Klovins, J | 1 |
| Montastier, E | 1 |
| Beuzelin, D | 1 |
| Martins, F | 1 |
| Mir, L | 1 |
| Marqués, MA | 1 |
| Thalamas, C | 1 |
| Iacovoni, J | 1 |
| Langin, D | 1 |
| Viguerie, N | 1 |
| Ahlström, C | 3 |
| Kroon, T | 4 |
| Peletier, LA | 2 |
| Gabrielsson, J | 6 |
| van den Hoek, AM | 1 |
| van der Hoorn, JW | 1 |
| Maas, AC | 1 |
| van den Hoogen, RM | 1 |
| van Nieuwkoop, A | 1 |
| Droog, S | 1 |
| Offerman, EH | 1 |
| Pieterman, EJ | 1 |
| Havekes, LM | 1 |
| Princen, HM | 1 |
| Niu, N | 1 |
| Sun, SZ | 1 |
| Han, B | 1 |
| Wang, Y | 1 |
| Tapani, S | 1 |
| Almquist, J | 3 |
| Leander, J | 2 |
| Jirstrand, M | 3 |
| Couturier, A | 1 |
| Ringseis, R | 2 |
| Most, E | 1 |
| Eder, K | 2 |
| Taylor, JK | 1 |
| Plaisance, EP | 2 |
| Mahurin, AJ | 2 |
| Mestek, ML | 1 |
| Moncada-Jimenez, J | 1 |
| Grandjean, PW | 2 |
| Hughes-Large, JM | 1 |
| Pang, DK | 1 |
| Robson, DL | 1 |
| Chan, P | 1 |
| Toma, J | 1 |
| Borradaile, NM | 1 |
| Chen, L | 1 |
| So, WY | 1 |
| Li, SY | 1 |
| Cheng, Q | 1 |
| Boucher, BJ | 1 |
| Leung, PS | 1 |
| Savinova, OV | 1 |
| Fillaus, K | 1 |
| Harris, WS | 1 |
| Shearer, GC | 1 |
| Kjellstedt, A | 1 |
| Thalén, P | 1 |
| Oakes, ND | 3 |
| Le Bloc'h, J | 2 |
| Leray, V | 2 |
| Nazih, H | 1 |
| Gauthier, O | 1 |
| Serisier, S | 1 |
| Magot, T | 2 |
| Krempf, M | 2 |
| Nguyen, P | 2 |
| Ouguerram, K | 2 |
| Misra, A | 1 |
| Bhardwaj, S | 1 |
| Wanders, D | 1 |
| Russo, L | 1 |
| Ghadieh, HE | 1 |
| Ghanem, SS | 1 |
| Al-Share, QY | 1 |
| Smiley, ZN | 1 |
| Gatto-Weis, C | 1 |
| Esakov, EL | 1 |
| McInerney, MF | 1 |
| Heinrich, G | 1 |
| Tong, X | 1 |
| Yin, L | 1 |
| Najjar, SM | 1 |
| Baccega, T | 1 |
| Olsén, A | 1 |
| Andersson, R | 1 |
| Evans, ND | 1 |
| Chappel, MJ | 1 |
| Xenoulis, PG | 1 |
| Steiner, JM | 1 |
| Kaushik, SV | 1 |
| Kim, T | 1 |
| Huang, EY | 1 |
| Mathews, ST | 1 |
| Ginsberg, HN | 1 |
| Maccallum, PR | 1 |
| Czapska, D | 1 |
| Ostrowska, L | 1 |
| Stefańska, E | 1 |
| Karczewski, J | 1 |
| Fabbrini, E | 1 |
| Mohammed, BS | 1 |
| Korenblat, KM | 1 |
| Magkos, F | 1 |
| McCrea, J | 1 |
| Patterson, BW | 1 |
| Klein, S | 1 |
| Chetiveaux, M | 1 |
| Freuchet, B | 1 |
| Li, D | 2 |
| Sun, WP | 2 |
| Zhou, YM | 2 |
| Liu, QG | 2 |
| Zhou, SS | 2 |
| Luo, N | 1 |
| Bian, FN | 1 |
| Zhao, ZG | 1 |
| Guo, M | 1 |
| Repas, T | 1 |
| Wu, J | 1 |
| Zhang, F | 1 |
| Yan, M | 1 |
| Wu, D | 1 |
| Yu, Q | 1 |
| Zhang, Y | 1 |
| Zhou, B | 1 |
| McBurney, MW | 1 |
| Zhai, Q | 1 |
| Hartman, R | 1 |
| Defelice, T | 1 |
| Tzu, J | 1 |
| Meehan, S | 1 |
| Sanchez, M | 1 |
| Nelson, RH | 1 |
| Vlazny, D | 1 |
| Smailovic, A | 1 |
| Miles, JM | 1 |
| Rosenbaum, S | 1 |
| Gessner, DK | 1 |
| Herges, L | 1 |
| Kubens, JF | 1 |
| Mooren, FC | 1 |
| Krüger, K | 1 |
| Talbert, RL | 1 |
| Pieper, JA | 1 |
| Ito, MK | 1 |
| LIUBSKAIA, II | 1 |
| SCHOEN, H | 1 |
| NEUMANN, J | 1 |
| VILAR DE LA PENA, V | 1 |
| Preuss, HG | 2 |
| Bagchi, D | 3 |
| Bagchi, M | 2 |
| Rao, CV | 2 |
| Dey, DK | 1 |
| Satyanarayana, S | 2 |
| Ferguson, LR | 1 |
| Karunasinghe, N | 1 |
| Philpott, M | 1 |
| Reasner, CA | 1 |
| Espinosa-Larrañaga, F | 1 |
| Vejar-Jalaf, M | 1 |
| Medina-Santillán, R | 1 |
| Garis, RI | 1 |
| Bramble, JD | 1 |
| Pins, JJ | 1 |
| Keenan, JM | 1 |
| Rink, C | 1 |
| Roy, S | 1 |
| Khanna, S | 1 |
| Rink, T | 1 |
| Sen, CK | 1 |
| Rana, JS | 1 |
| Nieuwdorp, M | 1 |
| Jukema, JW | 1 |
| Kastelein, JJ | 1 |
| Groop, LC | 1 |
| Ferrannini, E | 1 |
| Stone, OJ | 1 |
| Saloranta, C | 1 |
| Groop, L | 1 |
| Wilt, VM | 1 |
| Gums, JG | 1 |
| Boden, G | 1 |
| Chen, X | 1 |
| Iqbal, N | 1 |
| Dobbins, RL | 1 |
| Chester, MW | 1 |
| Daniels, MB | 1 |
| McGarry, JD | 1 |
| Stein, DT | 1 |
| Coughlan, BJ | 1 |
| Sorrentino, MJ | 1 |
| Safeer, RS | 1 |
| Cornell, MO | 1 |
| Renzetti, AR | 1 |
| Criscuoli, M | 1 |
| Subissi, A | 1 |
| Parker, F | 1 |
| Dawson, B | 1 |
| Favaloro, EJ | 1 |
| Taylor, J | 1 |
| Aggarwal, A | 1 |
| dos Santos, JE | 1 |
| Vannucchi, H | 1 |
| Marchini, JS | 1 |
| Dutra de Oliveira, J | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Nicotinic Acid on Adipose Tissue Inflammation in Obese Subjects[NCT01083329] | Phase 2 | 24 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Niacin, N-3 Fatty Acids and Insulin Resistance[NCT00286234] | Phase 4 | 68 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Non-HDL-C
Change From Baseline to 4 Months in Serum Non-HDL cholesterol (NCT00286234)
Timeframe: baseline and 4 months
| Intervention | mg/dl (Mean) |
|---|---|
| Dual Placebo | 145 |
| Niaspan | 155 |
| Lovaza | 133 |
| Combined Therapy | 170 |
Serum TG
Change From Baseline to 4 Months in Serum Triglycerides (NCT00286234)
Timeframe: 4 months
| Intervention | mg/dl (Mean) |
|---|---|
| Dual Placebo | 233 |
| Niaspan | 157 |
| Lovaza | 176 |
| Combined Therapy | 156 |
Reviews
14 reviews available for niacin and Obesity
| Article | Year |
|---|---|
Anti-inflammatory effects of the hydroxycarboxylic acid receptor 2.
Topics: Animals; Atherosclerosis; Colitis; Diabetic Retinopathy; Humans; Inflammation; Mice; Neoplasms; Neur | 2016 |
Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments.
Topics: Adipose Tissue; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acids, None | 2017 |
Lipid metabolism and hyperlipidemia in dogs.
Topics: Animals; Diet, Reducing; Dog Diseases; Dogs; Fatty Acids, Omega-3; Hyperlipidemias; Hypertriglycerid | 2010 |
The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: II. Therapeutic management of atherogenic dyslipidemia.
Topics: Cardiovascular Diseases; Clofibric Acid; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Dysli | 2009 |
Acanthosis nigricans in the setting of niacin therapy.
Topics: Acanthosis Nigricans; Cardiovascular Diseases; Diagnosis, Differential; Dyslipidemias; Epidermal Gro | 2011 |
What is the most effective strategy for managing diabetic dyslipidaemia?
Topics: Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Diabetes Mellitus; Diabetic Angiopathies; Drug | 2005 |
Dietary and nutraceutical options for managing the hypertriglyceridemic patient.
Topics: Dietary Carbohydrates; Energy Intake; Evidence-Based Medicine; Exercise; Fasting; Fish Oils; Humans; | 2006 |
Cardiovascular metabolic syndrome - an interplay of, obesity, inflammation, diabetes and coronary heart disease.
Topics: Cardiovascular Diseases; Coronary Disease; Diabetes Mellitus, Type 2; Dyslipidemias; Endothelium, Va | 2007 |
Insulin action and substrate competition.
Topics: Animals; Binding, Competitive; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Gluconeogenesi | 1993 |
Interactions between glucose and FFA metabolism in man.
Topics: Animals; Biological Transport; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Glucose; Human | 1996 |
"Isolated" low high-density lipoprotein cholesterol.
Topics: Cholesterol, HDL; Exercise; Humans; Life Style; Lipoproteins, HDL; Niacin; Obesity; Smoking | 1997 |
Does hypertriglyceridemia increase risk for CAD? Growing evidence suggests it plays a role.
Topics: Coronary Disease; Diabetes Complications; Evidence-Based Medicine; Humans; Hypertriglyceridemia; Hyp | 2000 |
The emerging role of HDL cholesterol. Is it time to focus more energy on raising high-density lipoprotein levels?
Topics: Alcohol Drinking; Body Weight; Cholesterol; Cholesterol, HDL; Coronary Disease; Dietary Fats; Estrog | 2000 |
Nutritional care of hospitalized patients in Brazil with particular reference to pellagra and alcoholism as complicating factors.
Topics: Administration, Oral; Alcoholism; Anorexia Nervosa; Brazil; Dietary Services; Enteral Nutrition; Hos | 1981 |
Trials
7 trials available for niacin and Obesity
| Article | Year |
|---|---|
Niacin induces miR-502-3p expression which impairs insulin sensitivity in human adipocytes.
Topics: Adipocytes; Adipose Tissue; Adult; Cells, Cultured; Double-Blind Method; Humans; Insulin Resistance; | 2019 |
Effects of niacin and omega-3 fatty acids on the apolipoproteins in overweight patients with elevated triglycerides and reduced HDL cholesterol.
Topics: Adult; Apolipoproteins; Biomarkers; Cholesterol, HDL; Delayed-Action Preparations; Double-Blind Meth | 2015 |
Extended-release niacin decreases serum fetuin-A concentrations in individuals with metabolic syndrome.
Topics: Adult; Aged; alpha-2-HS-Glycoprotein; Blood Proteins; C-Reactive Protein; Cholesterol, HDL; Delayed- | 2009 |
Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease.
Topics: Adult; Apolipoproteins B; Blood Glucose; Body Composition; Double-Blind Method; Fatty Acids, Noneste | 2010 |
Intravenous niacin acutely improves the efficiency of dietary fat storage in lean and obese humans.
Topics: Administration, Intravenous; Adult; Dietary Fats; Dyslipidemias; Female; Humans; Intra-Abdominal Fat | 2012 |
Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss.
Topics: Adult; Appetite; Biomarkers; Body Mass Index; Chromium; Citrates; Double-Blind Method; Drug Therapy, | 2004 |
Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control.
Topics: Adult; Anti-Obesity Agents; Body Mass Index; Body Weight; Calcium; Chromium; Citrates; Double-Blind | 2005 |
Other Studies
44 other studies available for niacin and Obesity
| Article | Year |
|---|---|
Discovery of coumarin-dihydroquinazolinone analogs as niacin receptor 1 agonist with in-vivo anti-obesity efficacy.
Topics: Animals; Anti-Obesity Agents; Coumarins; Diet, High-Fat; Dose-Response Relationship, Drug; Drug Disc | 2018 |
Dietary Micronutrient Status and Relation between Micronutrient Intakes and Overweight and Obesity among Non-Pregnant and Non-Lactating Women Aged 18 to 49 in China.
Topics: Adolescent; Adult; China; Diet; Eating; Female; Humans; Lactation; Male; Micronutrients; Middle Aged | 2022 |
Niacin exacerbates β cell lipotoxicity in diet-induced obesity mice through upregulation of GPR109A and PPARγ2: Inhibition by incretin drugs.
Topics: Animals; Blood Glucose; Diet; Incretins; Mice; Mice, Obese; Niacin; Obesity; Palmitates; PPAR gamma; | 2022 |
Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.
Topics: Adenylate Kinase; Animals; Diet, High-Fat; Gene Knockdown Techniques; Hep G2 Cells; Humans; Lipogene | 2020 |
Niacin increases diet-induced hepatic steatosis in B6129 mice.
Topics: Animals; Diet, High-Fat; Hypolipidemic Agents; Insulin Resistance; Lipid Metabolism; Lipoproteins, V | 2020 |
The Association between Breakfast Skipping and Body Weight, Nutrient Intake, and Metabolic Measures among Participants with Metabolic Syndrome.
Topics: Adult; Aged; Body Weight; Breakfast; Diet; Diet Records; Dietary Fats; Feeding Behavior; Female; Fol | 2017 |
Low dietary intake of n-3 fatty acids, niacin, folate, and vitamin C in Korean patients with schizophrenia and the development of dietary guidelines for schizophrenia.
Topics: Adult; Ascorbic Acid; Diet; Fatty Acids, Omega-3; Feeding Behavior; Female; Folic Acid; Humans; Male | 2017 |
Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans.
Topics: Adult; Case-Control Studies; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Drug Compoundin | 2018 |
Hydroxycarboxylic Acid Receptor Ligands Modulate Proinflammatory Cytokine Expression in Human Macrophages and Adipocytes without Affecting Adipose Differentiation.
Topics: Adipocytes; Adipogenesis; Adipose Tissue; Atherosclerosis; Cells, Cultured; Cytokines; Gene Expressi | 2018 |
Feedback modeling of non-esterified fatty acids in obese Zucker rats after nicotinic acid infusions.
Topics: Animals; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Feedback, Physiological; Infu | 2013 |
APOE*3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Apolipoprotein E3; Atorvastatin; Cholesterol E | 2014 |
[Relationship of ox-LDL/LOX-1 and vascular endothelial dysfunction of diet-induced obese immature rats and nicotinic acid's intervention outcomes].
Topics: Animals; Endothelium, Vascular; Hyperlipidemias; Intercellular Adhesion Molecule-1; Lipoproteins, LD | 2013 |
Joint feedback analysis modeling of nonesterified fatty acids in obese Zucker rats and normal Sprague-Dawley rats after different routes of administration of nicotinic acid.
Topics: Animals; Drug Administration Routes; Fatty Acids, Nonesterified; Hypolipidemic Agents; Male; Models, | 2014 |
Pharmacological doses of niacin stimulate the expression of genes involved in carnitine uptake and biosynthesis and improve the carnitine status of obese Zucker rats.
Topics: Aldehyde Oxidoreductases; Animals; Base Sequence; Carnitine; DNA Primers; gamma-Butyrobetaine Dioxyg | 2014 |
Paraoxonase responses to exercise and niacin therapy in men with metabolic syndrome.
Topics: Adult; Apolipoprotein A-I; Aryldialkylphosphatase; Exercise; Exercise Therapy; Humans; Lipids; Lipop | 2015 |
Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity.
Topics: Animals; Aorta; Apoptosis; Cattle; Cell Death; Cell Movement; Cell Proliferation; Cells, Cultured; C | 2014 |
Niacin-induced hyperglycemia is partially mediated via niacin receptor GPR109a in pancreatic islets.
Topics: Animals; Cell Line; Disease Models, Animal; Glucose; Hyperglycemia; Hypolipidemic Agents; Insulin; I | 2015 |
Mixed Effects Modeling Using Stochastic Differential Equations: Illustrated by Pharmacokinetic Data of Nicotinic Acid in Obese Zucker Rats.
Topics: Animals; Computer Simulation; Models, Biological; Niacin; Nonlinear Dynamics; Obesity; Rats; Rats, Z | 2015 |
Dosing profile profoundly influences nicotinic acid's ability to improve metabolic control in rats.
Topics: Adipose Tissue; Animals; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Glucose; Insu | 2015 |
Nicotinic Acid Accelerates HDL Cholesteryl Ester Turnover in Obese Insulin-Resistant Dogs.
Topics: Animals; Cholesterol Ester Transfer Proteins; Cholesterol Esters; Cholesterol, HDL; Dogs; Hypolipide | 2015 |
Management of the Metabolic Syndrome and the Obese Patient with Metabolic Disturbances: South Asian Perspective.
Topics: Adipose Tissue; Asia; Asian People; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diet; Dietar | 2015 |
Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis.
Topics: Adipocytes; Adipose Tissue, White; Animals; Carcinoembryonic Antigen; Cells, Cultured; Diet, High-Fa | 2016 |
Nicotinic acid timed to feeding reverses tissue lipid accumulation and improves glucose control in obese Zucker rats[S].
Topics: Animals; Blood Glucose; Fasting; Fatty Acids; Glucose; Glucose Tolerance Test; Humans; Hypertriglyce | 2017 |
[Assessment of selected vitamins content in daily food rations of obese patients].
Topics: Adult; Diet; Dietary Supplements; Feeding Behavior; Female; Folic Acid; Humans; Male; Middle Aged; N | 2009 |
Nicotinic acid decreases apolipoprotein B100-containing lipoprotein levels by reducing hepatic very low density lipoprotein secretion through a possible diacylglycerol acyltransferase 2 inhibition in obese dogs.
Topics: Animals; Apolipoprotein B-100; Diacylglycerol O-Acyltransferase; Dogs; Insulin Resistance; Kinetics; | 2010 |
Chronic niacin overload may be involved in the increased prevalence of obesity in US children.
Topics: Adolescent; Adult; Appetite; Biomarkers; Blood Glucose; Child; Child, Preschool; Feeding Behavior; G | 2010 |
B-vitamin consumption and the prevalence of diabetes and obesity among the US adults: population based ecological study.
Topics: Adult; Age Distribution; Aged; Centers for Disease Control and Prevention, U.S.; Diabetes Mellitus, | 2010 |
Obesity and dyslipidemia.
Topics: Anti-Obesity Agents; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Dyslipidemias; Humans; H | 2011 |
WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; C-Peptide; Cell Line, Tumor; Diet, High-Fat; Flu | 2011 |
Supplementing obese Zucker rats with niacin induces the transition of glycolytic to oxidative skeletal muscle fibers.
Topics: Animals; Dietary Supplements; Gene Expression Regulation; Glycolysis; Hypolipidemic Agents; Lipid Mo | 2013 |
Niacin and the National Cholesterol Education Program Adult Treatment Panel III Guidelines: case studies.
Topics: Aspirin; Atenolol; Blood Chemical Analysis; Coronary Disease; Female; Humans; Hyperlipidemias; Hyper | 2003 |
[Use of phenatin in treatment of obesity; preliminary report].
Topics: Niacin; Nicotinic Acids; Nikethamide; Obesity | 1958 |
[STUDIES ON THE INFLUENCING OF FAT CLEARANCE IN VIVO].
Topics: Adenosine Triphosphate; Arteriosclerosis; Dietary Fats; Heparin; Hyperlipidemias; Hypertension; Iodi | 1964 |
[Some secondary effects of isoniazid of probable diencephalic origin].
Topics: Aminosalicylic Acid; Isoniazid; Niacin; Nicotinic Acids; Obesity; Probability; Thiosemicarbazones | 1955 |
Epigenetic events and protection from colon cancer in New Zealand.
Topics: Alcohol Drinking; Colonic Neoplasms; Dietary Fiber; DNA Methylation; Folic Acid; Genistein; Humans; | 2004 |
The importance of low serum levels of high-density lipoprotein cholesterol (HDL-C) as a cardiovascular risk factor.
Topics: Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Combined Modality Therapy; Diabetes Complicat | 2005 |
Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Leprdb obese diabetic mice with niacin-bound chromium.
Topics: Adipose Tissue; Administration, Oral; Animals; Apoptosis Regulatory Proteins; Blood Glucose; Cholest | 2006 |
Acanthosis nigricans--decreased extracellular matrix viscosity: cancer, obesity, diabetes, corticosteroids, somatotrophin.
Topics: Acanthosis Nigricans; Adrenal Cortex Hormones; Diabetes Complications; Extracellular Matrix; Female; | 1993 |
Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and nondiabetic subjects.
Topics: 3-Hydroxybutyric Acid; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Emulsions; Fat Emulsions, Int | 1998 |
Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans.
Topics: Adult; Blood Glucose; C-Peptide; Fasting; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Fe | 1998 |
Further assessment of glunicate hypolipidaemic activity in the rat.
Topics: Animals; Blood Glucose; Female; Hypolipidemic Agents; Lipids; Male; Niacin; Niacinamide; Obesity; Ra | 1985 |
Xanthomas and hyperlipidemias.
Topics: Apoproteins; Arteriosclerosis; Cholestasis; Cholestyramine Resin; Clofibrate; Colestipol; Dextrothyr | 1985 |
PELLAGRA secondary to antiobesity diet.
Topics: Diet; Humans; Obesity; Pellagra | 1955 |
Unrecognized pellagra masquerading as odynophagia.
Topics: Aged; Deglutition Disorders; Diagnostic Errors; Female; Humans; Niacinamide; Obesity; Pellagra; Prea | 2006 |