naloxone and Rosacea

naloxone has been researched along with Rosacea* in 2 studies

Trials

1 trial(s) available for naloxone and Rosacea

ArticleYear
[Rosacea].
    Presse medicale (Paris, France : 1983), 1988, Dec-17, Volume: 17, Issue:45

    Rosacea should no longer be considered a follicular skin disease. It is a vascular disease of the face characterized by a significant evolution towards local complications such as telangiectasias, papular and aseptic pustular lesions, lupoid granulomas, chronic facial oedema and seboglandular hyperplasia. The basic abnormality seems to be a microcirculatory disturbance of the function of the facial angular veins directly involved in the brain-cooling vascular mechanism. The first clinic hallmark of this dysfunction is the occurrence of flushing, which may be spontaneous or induced by alcohol, intake of hot food, emotional stress and sudden variations in temperature. Tetracycline, metronidazole and isotretinoin are very useful for therapy but they only influence the cutaneous and ocular complications and do not act upon the basic vascular trouble. Current therapeutic research is directed towards drugs having an alpha-sympathomimetic activity and inhibiting the endogenous opioid mediators of flushing such as naloxone or clonidine.

    Topics: Body Temperature; Clinical Trials as Topic; Clonidine; Female; Humans; Isotretinoin; Male; Metronidazole; Naloxone; Rosacea; Tetracyclines

1988

Other Studies

1 other study(ies) available for naloxone and Rosacea

ArticleYear
Alcohol-induced rosacea flushing blocked by naloxone.
    The British journal of dermatology, 1982, Volume: 107, Issue:1

    We evaluated the roles of endogenous opioid peptides and histamine in the pathophysiology of alcohol-induced facial flushing in rosacea. Non-diabetic patients with rosacea ingested 360 ml of 6% ethanol after receiving either subcutaneous naloxone hydrochloride or oral chloropheniramine maleate. Only pretreatment with naloxone blocked the alcohol-induced rosacea flushing (AIRF), suggesting an active role of endogenous enkephalin and/or endorphin in this vascular reactivity. In this respect, AIRF is similar to chlorpropamide alcohol flushing and menopausal flushing.

    Topics: Adult; Alcoholic Beverages; Chlorpheniramine; Double-Blind Method; Face; Female; Humans; Male; Middle Aged; Naloxone; Rosacea; Skin; Skin Temperature; Vasodilation

1982