nafarelin and Dizziness
nafarelin has been researched along with Dizziness* in 1 studies
Trials
1 trial(s) available for nafarelin and Dizziness
Article | Year |
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Treatment of endometriosis with a decreasing dosage of a gonadotropin-releasing hormone agonist (nafarelin): a pilot study with low-dose agonist therapy ("draw-back" therapy).
To evaluate the efficacy of half-dose GnRH agonist therapy for endometriosis.. Prospective, longitudinal pilot study.. Osaka University Hospital.. Patients with symptomatic endometriosis.. Fifteen patients were randomized to receive either full-dose nafarelin treatment (200 microgram b.i.d.) for 24 weeks (n = 7) or full-dose nafarelin treatment for 4 weeks followed by half-dose nafarelin treatment (200 microgram daily) for 20 weeks (n = 8).. Clinical symptoms and the results of physical examinations. Serum E(2) and carcinoma antigen 125 (CA125) levels, lipid profiles, and urinary levels of the N-telopeptide of type I collagen. Bone mineral density of the lumbar spine.. Subjective and objective manifestations of endometriosis were decreased to a similar extent in both study groups. Adverse effects were markedly reduced with half-dose administration. In the half-dose group, the mean serum E(2) level was significantly suppressed by 4 weeks of treatment with full-dose nafarelin and remained at approximately 30 pg/mL with half-dose nafarelin. Loss of bone mineral density was significantly less with half-dose treatment.. Half-dose administration of nafarelin after pituitary down-regulation with full-dose nafarelin ("draw-back" therapy) is a new protocol for the treatment of endometriosis that is effective and associated with fewer adverse effects. Topics: Administration, Intranasal; Bone Density; CA-125 Antigen; Collagen; Dizziness; Dose-Response Relationship, Drug; Down-Regulation; Endometriosis; Estradiol; Female; Gonadotropin-Releasing Hormone; Hormones; Humans; Longitudinal Studies; Lumbar Vertebrae; Menstrual Cycle; Nafarelin; Pilot Projects; Prospective Studies | 2000 |