n-trans-p-coumaroyl-l-tyrosine and Alzheimer-Disease

n-trans-p-coumaroyl-l-tyrosine has been researched along with Alzheimer-Disease* in 1 studies

Other Studies

1 other study(ies) available for n-trans-p-coumaroyl-l-tyrosine and Alzheimer-Disease

ArticleYear
Structure-activity relationship of clovamide and its related compounds for the inhibition of amyloid β aggregation.
    Bioorganic & medicinal chemistry, 2018, 07-23, Volume: 26, Issue:12

    Alzheimer's disease (AD), a neurodegenerative disorder, is characterized by aggregation of amyloid β-protein (Aβ). Aβ aggregates through β-sheet formation and induces cytotoxicity against neuronal cells. Inhibition of Aβ aggregation by naturally occurring compounds is thus a promising strategy for the treatment of AD. We have already reported that caffeoylquinic acids and phenylethanoid glycosides, which possess two or more catechol moieties, strongly inhibited Aβ aggregation. Clovamide (1) containing two catechol moieties, isolated from cacao beans (Theobroma cacao L.), is believed to exhibit preventive effects on Aβ aggregation. To investigate the structure-activity relationship of clovamide (1) for the inhibition of Aβ aggregation, we synthesized 1 and related compounds 2-11 through reaction between l-DOPA, d-DOPA, l-tyrosine, or l-phenylalanine and caffeic acid, p-coumaric acid, or cinnamic acid, and compounds 12 and 13 were derived from 1. Among tested compounds 1-13, those containing one or two catechol moieties exhibited potent anti-aggregation activity, whereas the non-catechol-type related compounds showed little or no activity. This suggests that at least one catechol moiety is essential for inhibition of Aβ42 aggregation, and this activity increases depending on the number of catechol moieties. Consequently, clovamide (1) and its related compounds may be a promising therapeutic option for inhibiting Aβ-mediated pathology in AD.

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Cacao; Catechols; Cinnamates; Dihydroxyphenylalanine; Humans; Inhibitory Concentration 50; Structure-Activity Relationship; Tyrosine

2018
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