mupirocin and Abscess

Topics: Abscess; Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Communicable Diseases, Emerging; Female; Foot Diseases; Fusidic Acid; Humans; Insect Bites and Stings; Male; Middle Aged; Mupirocin; Soft Tissue Infections; Staphylococcal Skin Infections; Staphylococcus lugdunensis; Wound Infection

The oxacillin- and cefoxitin-susceptible

Topics: Abscess; Anti-Bacterial Agents; Bacterial Proteins; Cefoxitin; Female; Genomics; Humans; Lactation; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mupirocin; Oxacillin; Penicillin-Binding Proteins; Staphylococcal Infections; Staphylococcus aureus

Whether decolonization following incision and drainage (I&D) for methicillin-resistant Staphylococcus aureus (MRSA) abscess decreases repeat I&D and MRSA-positive cultures in children is unknown.. Referral to the Pediatric Infectious Disease Service (PIDS) for decolonization was determined for eligible children (2003-2010), with outcomes studied over 12 months.. We identified 653 children; 54 had been seen by PIDS. In the PIDS group, no patients (0/54, 0%) had a repeat I&D. In the no PIDS group 36/599 (6%) had a repeat I&D, P = .06. Logistic regression modeling for repeat I&D showed no significant effect, odds ratio = 0.29; 95% confidence interval = 0.04-2.15; P = .23. In the PIDS group, 3 patients (3/54, 5.6%) had a repeat MRSA-positive culture. In the no PIDS group, 58/599 (9.7%) had a positive repeat culture, P = .46. Logistic regression modeling for positive culture showed no significant effect (odds ratio = 0.55; 95% confidence interval = 0.17-1.81; P = .32).. We detected no statistically significant association between decolonization and repeat I&D or MRSA-positive culture.

Topics: Abscess; Administration, Intranasal; Anti-Bacterial Agents; Baths; Child; Child, Preschool; Cohort Studies; Disinfectants; Drainage; Female; Humans; Longitudinal Studies; Male; Methicillin-Resistant Staphylococcus aureus; Mupirocin; Retrospective Studies; Risk Factors; Sodium Hypochlorite; Staphylococcal Infections; Treatment Outcome

Lip abscesses are a potentially serious condition rarely reported in the medical literature. This disease requires prompt diagnosis and treatment with hospitalization, intravenous antibiotics, and urgent surgical drainage. Clinical knowledge of this condition is essential to guide the differential diagnosis and correctly adapt the etiological treatment. The presence of necrotic and cavitated lesions requires ruling out immunosupression or methicillin-resistant agent. We report a necrotic and cavitated bacterial lip abscess caused by methicillin-sensitive Staphylococcus aureus in an immunocompetent male.

Topics: Abscess; Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Cheilitis; Cloxacillin; Combined Modality Therapy; Drainage; Humans; Immunocompetence; Male; Mupirocin; Staphylococcal Skin Infections; Staphylococcus aureus

Topics: Abscess; Adolescent; Anti-Bacterial Agents; Combined Modality Therapy; Community-Acquired Infections; Doxycycline; Drainage; Drug Therapy, Combination; Female; Humans; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Mupirocin; Staphylococcal Skin Infections

Topics: Abscess; Administration, Intranasal; Adult; Anti-Bacterial Agents; Down Syndrome; Humans; Male; Methicillin Resistance; Mupirocin; Staphylococcal Skin Infections; Staphylococcus aureus

Potent nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase have been derived from a file compound high throughput screening hit. Optimized compounds show excellent antibacterial activity against staphylococcal and enterococcal pathogens, including strains resistant to clinical antibiotics. Compound 11 demonstrated in vivo efficacy in an S. aureus rat abscess infection model.

Topics: Abscess; Animals; Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Enzyme Inhibitors; Methionine-tRNA Ligase; Quinolones; Rats; Rats, Sprague-Dawley; Staphylococcus; Staphylococcus aureus; Structure-Activity Relationship