modafinil and Aura
modafinil has been researched along with Aura in 4 studies
Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Modafinil, is a wake-promoting drug approved by Food and Drugs Administration (FDA) for narcolepsy and sleep-apnoe syndrome." | 5.42 | Effects of modafinil on pentylenetetrazol-induced convulsive epilepsy. ( Aydin, D; Ekici, F; Ozsoy, S, 2015) |
| "Modafinil has been shown to ameliorate these symptoms, but its use in patients with seizures has been limited because of safety concerns." | 5.38 | Use of modafinil in patients with epilepsy. ( Artsy, E; Dworetzky, BA; Hurwitz, S; Lee, JW; McCarthy, DC; Pavlova, MK, 2012) |
| " In summary, reading the prescribing information, writing to the drug manufacturer, and searching research databases suggest the following: Ar/mod and its metabolites and derivatives have dose-dependent anticonvulsant action in animal models; ar/mod is not associated with seizures as an adverse event in populations at risk, such as those with ADHD, head injury, and brain tumors; it is not associated with worsening of seizure disorder in patients with current seizure disorder; and it is not associated with seizures in overdose." | 1.43 | A method for deciding about the possible safety of modafinil and armodafinil in patients with seizure disorder. ( Andrade, C, 2016) |
| "Modafinil, is a wake-promoting drug approved by Food and Drugs Administration (FDA) for narcolepsy and sleep-apnoe syndrome." | 1.42 | Effects of modafinil on pentylenetetrazol-induced convulsive epilepsy. ( Aydin, D; Ekici, F; Ozsoy, S, 2015) |
| "Modafinil has been shown to ameliorate these symptoms, but its use in patients with seizures has been limited because of safety concerns." | 1.38 | Use of modafinil in patients with epilepsy. ( Artsy, E; Dworetzky, BA; Hurwitz, S; Lee, JW; McCarthy, DC; Pavlova, MK, 2012) |
| " In addition, modafinil at 180 mg/kg exerted an antiepileptic effect in the MES model; however, at the same dosage it increased the seizure stage in the PTZ-kindling model." | 1.34 | Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice. ( Chen, CR; Huang, ZL; Qiu, MH; Qu, WM; Urade, Y; Xu, XH; Yao, MH, 2007) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ozsoy, S | 1 |
| Aydin, D | 1 |
| Ekici, F | 1 |
| Andrade, C | 1 |
| Artsy, E | 1 |
| McCarthy, DC | 1 |
| Hurwitz, S | 1 |
| Pavlova, MK | 1 |
| Dworetzky, BA | 1 |
| Lee, JW | 1 |
| Chen, CR | 1 |
| Qu, WM | 1 |
| Qiu, MH | 1 |
| Xu, XH | 1 |
| Yao, MH | 1 |
| Urade, Y | 1 |
| Huang, ZL | 1 |
Other Studies
4 other studies available for modafinil and Aura
| Article | Year |
|---|---|
Effects of modafinil on pentylenetetrazol-induced convulsive epilepsy.
Topics: Animals; Anticonvulsants; Benzhydryl Compounds; Brain; Disease Models, Animal; Dose-Response Relatio | 2015 |
A method for deciding about the possible safety of modafinil and armodafinil in patients with seizure disorder.
Topics: Animals; Benzhydryl Compounds; Clinical Decision-Making; Epilepsy; Humans; Modafinil; Wakefulness-Pr | 2016 |
Use of modafinil in patients with epilepsy.
Topics: Adult; Aged; Aged, 80 and over; Benzhydryl Compounds; Electroencephalography; Epilepsy; Female; Huma | 2012 |
Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice.
Topics: Animals; Benzhydryl Compounds; Disease Models, Animal; Electroencephalography; Electroshock; Epileps | 2007 |