Page last updated: 2024-10-31

modafinil and Ache

modafinil has been researched along with Ache in 6 studies

Modafinil: A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
modafinil : A racemate comprising equimolar amounts of armodafinil and (S)-modafinil. A central nervous system stimulant, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The optical enantiomers of modafinil have similar pharmacological actions in animals.
2-[(diphenylmethyl)sulfinyl]acetamide : A sulfoxide that is dimethylsulfoxide in which two hydrogens attached to one of the methyl groups are replaced by phenyl groups, while one hydrogen attached to the other methyl group is replaced by a carbamoyl (aminocarbonyl) group.

Research Excerpts

ExcerptRelevanceReference
"Modafinil 200 mg was administered to the treatment group patients 1 h before sedation/analgesia."2.75Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. ( Boesjes, H; Galvin, E; Hol, J; Klein, J; Ubben, JF; Verbrugge, SJ, 2010)
"The consequences of chronic insufficient sleep for health remain uncertain."1.46Decreased alertness due to sleep loss increases pain sensitivity in mice. ( Alexandre, C; Ferreira, A; Latremoliere, A; Miracca, G; Scammell, TE; Woolf, CJ; Yamamoto, M, 2017)
"Modafinil was administered in the doses of 50, 100 or 200 mg/kg once in acute study and it showed significantly increased tail-flick latency (tfl) and paw-licking latency."1.40Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole. ( Bhattacharya, SK; Gupta, LK; Gupta, R, 2014)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alexandre, C1
Latremoliere, A1
Ferreira, A1
Miracca, G1
Yamamoto, M1
Scammell, TE1
Woolf, CJ1
Gupta, R1
Gupta, LK1
Bhattacharya, SK1
Hampton, T1
Galvin, E1
Boesjes, H1
Hol, J1
Ubben, JF1
Klein, J1
Verbrugge, SJ1
Webster, L1
Andrews, M1
Stoddard, G1
Taneja, I1
Bruehl, S1
Robertson, D1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102]Phase 4105 participants (Actual)Interventional2016-02-29Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit

Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours

Interventionminutes (Mean)
Placebo53.5
Modafinil61.0

Postanesthesia Quality Recovery Scale Score

Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery

Interventionunits on a scale (Mean)
Placebo-5.67
Modafinil-8.91

Trials

2 trials available for modafinil and Ache

ArticleYear
Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia Recovery Period; Anesthetics, Inha

2010
Effect of modafinil on acute pain: a randomized double-blind crossover study.
    Journal of clinical pharmacology, 2004, Volume: 44, Issue:12

    Topics: Acute Disease; Administration, Oral; Adult; Benzhydryl Compounds; Cross-Over Studies; Double-Blind M

2004

Other Studies

4 other studies available for modafinil and Ache

ArticleYear
Decreased alertness due to sleep loss increases pain sensitivity in mice.
    Nature medicine, 2017, Volume: 23, Issue:6

    Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Chronic Diseas

2017
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
    European journal of pharmacology, 2014, Aug-05, Volume: 736

    Topics: Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Form

2014
Cancer investigators make strides in improving patients' quality of life.
    JAMA, 2008, Jul-23, Volume: 300, Issue:4

    Topics: Acupuncture Therapy; Benzhydryl Compounds; Central Nervous System Stimulants; Fatigue; Humans; Modaf

2008
Modafinil treatment of opioid-induced sedation.
    Pain medicine (Malden, Mass.), 2003, Volume: 4, Issue:2

    Topics: Adult; Analgesics, Opioid; Benzhydryl Compounds; Central Nervous System Stimulants; Disorders of Exc

2003