midazolam and Sepsis
midazolam has been researched along with Sepsis in 16 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with suspected sepsis and who received a single bolus dose of etomidate for rapid sequence intubation showed no significant increase in hospital length of stay compared with patients who received a single bolus dose of midazolam." | 9.14 | A comparison of the effects of etomidate and midazolam on hospital length of stay in patients with suspected sepsis: a prospective, randomized study. ( Kulstad, EB; Rzechula, KH; Sweis, RT; Tekwani, KL; Watts, HF, 2010) |
| " Emergency surgery, more doses of midazolam, and fentanyl may be independent risk factors for SAD in mechanically ventilated patients with sepsis." | 5.34 | Incidence, risk factors, and outcomes for sepsis-associated delirium in patients with mechanical ventilation: A sub-analysis of a multicenter randomized controlled trial. ( Kawazoe, Y; Miyamoto, K; Mizobata, Y; Morimoto, T; Ohta, Y; Yamamoto, T; Yamamura, H, 2020) |
| "Sepsis was induced in rats by cecal ligation and puncture." | 5.31 | Propofol depressed neutrophil hydrogen peroxide production more than midazolam, whereas adhesion molecule expression was minimally affected by both anesthetics in rats with abdominal sepsis. ( Fujisawa, J; Inada, T; Kobayashi, Y; Nakao, S; Shingu, K; Taniuchi, S, 2001) |
| "Patients with suspected sepsis and who received a single bolus dose of etomidate for rapid sequence intubation showed no significant increase in hospital length of stay compared with patients who received a single bolus dose of midazolam." | 5.14 | A comparison of the effects of etomidate and midazolam on hospital length of stay in patients with suspected sepsis: a prospective, randomized study. ( Kulstad, EB; Rzechula, KH; Sweis, RT; Tekwani, KL; Watts, HF, 2010) |
| "An open, prospective study was carried out on 45 patients with multiple injuries to compare the mortality and incidence of sepsis between those given early total enteral nutrition (TEN) when sedated with propofol and historical controls who had been given total parenteral nutrition (TPN) and sedated with midazolam." | 5.07 | Long-term sedation in the ICU: enteral versus parenteral feeding. ( Bataillie, K; Baute, L; Demeyer, I, 1994) |
| "In a recent issue of Critical Care, Qiao and colleagues showed in a rat model of sepsis that dexmedetomidine and midazolam suppress the generation of pro-inflammatory mediators but the effects vary between agents." | 3.75 | Immunosedation: a consideration for sepsis. ( MacLaren, R, 2009) |
| " Therefore, we tested the dose-response direct cardiac effects of clinically available induction agents in an isolated septic rat heart model." | 1.35 | Cardiac effects of induction agents in the septic rat heart. ( Busse, H; Graf, BM; Lunz, D; Sinner, B; Zausig, YA; Zink, W, 2009) |
| "Sepsis was induced in rats by cecal ligation and puncture." | 1.31 | Propofol depressed neutrophil hydrogen peroxide production more than midazolam, whereas adhesion molecule expression was minimally affected by both anesthetics in rats with abdominal sepsis. ( Fujisawa, J; Inada, T; Kobayashi, Y; Nakao, S; Shingu, K; Taniuchi, S, 2001) |
Research
Studies (16)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 9 (56.25) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Patel, C | 1 |
| Kleinig, P | 1 |
| Bakker, M | 1 |
| Tait, P | 1 |
| Yamamoto, T | 1 |
| Mizobata, Y | 1 |
| Kawazoe, Y | 1 |
| Miyamoto, K | 1 |
| Ohta, Y | 1 |
| Morimoto, T | 1 |
| Yamamura, H | 1 |
| Zombori, L | 1 |
| Bacon, M | 1 |
| Wood, H | 1 |
| Chatterjee, F | 1 |
| Venkateswaran, R | 1 |
| Lampariello, S | 1 |
| Yoong, M | 1 |
| Chen, L | 1 |
| Meng, K | 1 |
| Su, W | 1 |
| Fu, Y | 1 |
| Rady, MY | 1 |
| Patel, BM | 1 |
| Larson, JS | 1 |
| DePriest, J | 1 |
| Gonzalez, L | 1 |
| Gupta, A | 1 |
| Lee, D | 1 |
| Su, M | 1 |
| Paciullo, C | 1 |
| Qiao, H | 1 |
| Sanders, RD | 1 |
| Ma, D | 1 |
| Wu, X | 1 |
| Maze, M | 1 |
| Zausig, YA | 1 |
| Busse, H | 1 |
| Lunz, D | 1 |
| Sinner, B | 1 |
| Zink, W | 1 |
| Graf, BM | 1 |
| MacLaren, R | 1 |
| Tekwani, KL | 1 |
| Watts, HF | 1 |
| Sweis, RT | 1 |
| Rzechula, KH | 1 |
| Kulstad, EB | 1 |
| Hoemberg, M | 1 |
| Vierzig, A | 1 |
| Roth, B | 1 |
| Eifinger, F | 1 |
| Memiş, D | 1 |
| Hekimoğlu, S | 1 |
| Vatan, I | 1 |
| Yandim, T | 1 |
| Yüksel, M | 1 |
| Süt, N | 1 |
| Demeyer, I | 1 |
| Bataillie, K | 1 |
| Baute, L | 1 |
| Inada, T | 1 |
| Taniuchi, S | 1 |
| Shingu, K | 1 |
| Kobayashi, Y | 1 |
| Fujisawa, J | 1 |
| Nakao, S | 1 |
Clinical Trials (8)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Modified Hospital Elder Life Program at Intensive Care Unit: A Stepped-Wedge Cluster Randomized Controlled Trial[NCT06054828] | 266 participants (Anticipated) | Interventional | 2023-09-05 | Recruiting | |||
| the Effect of Single Dose of Etomidate Used During Emergency Intubation on Hemodynamics and Adrenal Cortex: a Randomized Clinical Trial[NCT01792037] | Phase 4 | 90 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| A Randomized Trial of Etomidate Versus Midazolam for Intubation of Patients With Sepsis.[NCT00441792] | 122 participants (Actual) | Interventional | 2007-10-31 | Completed | |||
| A Randomised Active-controlled Study to Compare Efficacy & Safety of Inhaled Isoflurane Delivered by the AnaConDa-S (Anaesthetic Conserving Device) vs IV Midazolam for Sedation in Mechanically Ventilated Paediatric Patients 3-17 Years Old[NCT04684238] | Phase 3 | 97 participants (Actual) | Interventional | 2021-01-14 | Completed | ||
| Impact of Dexmedetomidine Supplemented Analgesia on Long-term Survival in Elderly Patients After Cancer Surgery: a Multicenter Randomized Controlled Trial[NCT03012971] | 1,500 participants (Actual) | Interventional | 2017-01-06 | Active, not recruiting | |||
| Intraoperative Propofol and Dexmedetomidine on Peripheral Inflammation Induced by Hip or Knee Arthroplasty.[NCT03600727] | 200 participants (Anticipated) | Interventional | 2018-08-31 | Not yet recruiting | |||
| Impact of Intraoperative Goal-directed Blood Pressure Management and Dexmedetomidine on Outcomes of High-risk Patients After Major Abdominal Surgeries: a 2×2 Factorial Randomized Controlled Trial[NCT03933306] | Phase 4 | 496 participants (Actual) | Interventional | 2019-05-20 | Active, not recruiting | ||
| Impact of Dexmedetomidine Supplemented Analgesia on Incidence of Delirium in Elderly Patients After Cancer Surgery: a Multicenter Randomized Controlled Trial[NCT03012984] | 1,500 participants (Actual) | Interventional | 2017-01-06 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Length of Stay
The primary outcome of the study was hospital length of stay. (NCT00441792)
Timeframe: time in days of hospitalization
| Intervention | days (Median) |
|---|---|
| Midazolam | 9.5 |
| Etomidate | 7.3 |
Mortality
In-hospital mortality. (NCT00441792)
Timeframe: Duration of hospitalization.
| Intervention | percentage of patients dying (Number) |
|---|---|
| Midazolam | 36 |
| Etomidate | 43 |
Reviews
1 review available for midazolam and Sepsis
| Article | Year |
|---|---|
Palliative sedation: A safety net for the relief of refractory and intolerable symptoms at the end of life.
Topics: Aged; Analgesics; Conscious Sedation; Dehydration; Dyspnea; Humans; Hydromorphone; Hypnotics and Sed | 2019 |
Trials
5 trials available for midazolam and Sepsis
| Article | Year |
|---|---|
Incidence, risk factors, and outcomes for sepsis-associated delirium in patients with mechanical ventilation: A sub-analysis of a multicenter randomized controlled trial.
Topics: Aged; Aged, 80 and over; Critical Care; Delirium; Female; Fentanyl; Hospital Mortality; Humans; Hypn | 2020 |
The Effect of Continuous Sedation Therapy on Immunomodulation, Plasma Levels of Antioxidants, and Indicators of Tissue Repair in Post-Burn Sepsis Patients.
Topics: Adult; Aged; Antioxidants; Burns; Enzyme-Linked Immunosorbent Assay; Female; Gelsolin; HSP70 Heat-Sh | 2015 |
A comparison of the effects of etomidate and midazolam on hospital length of stay in patients with suspected sepsis: a prospective, randomized study.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Etomidate; Female; Humans; Hypnotics and Sedatives; In | 2010 |
A comparison of the effects of etomidate and midazolam on hospital length of stay in patients with suspected sepsis: a prospective, randomized study.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Etomidate; Female; Humans; Hypnotics and Sedatives; In | 2010 |
A comparison of the effects of etomidate and midazolam on hospital length of stay in patients with suspected sepsis: a prospective, randomized study.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Etomidate; Female; Humans; Hypnotics and Sedatives; In | 2010 |
A comparison of the effects of etomidate and midazolam on hospital length of stay in patients with suspected sepsis: a prospective, randomized study.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Etomidate; Female; Humans; Hypnotics and Sedatives; In | 2010 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Effects of midazolam and dexmedetomidine on inflammatory responses and gastric intramucosal pH to sepsis, in critically ill patients.
Topics: Critical Illness; Dexmedetomidine; Gastric Acidity Determination; Gastric Mucosa; Humans; Hydrogen-I | 2007 |
Long-term sedation in the ICU: enteral versus parenteral feeding.
Topics: Adult; APACHE; Enteral Nutrition; Female; Humans; Injury Severity Score; Male; Midazolam; Multiple T | 1994 |
Other Studies
10 other studies available for midazolam and Sepsis
| Article | Year |
|---|---|
Severe cortical damage associated with COVID-19 case report.
Topics: Acute Kidney Injury; Adolescent; Airway Extubation; Anticonvulsants; Blood Coagulation Disorders; Bo | 2021 |
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU.
Topics: Adrenergic alpha-Agonists; Conscious Sedation; Critical Care; Dexmedetomidine; GABA Modulators; Huma | 2009 |
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU.
Topics: Adrenergic alpha-Agonists; Conscious Sedation; Critical Care; Dexmedetomidine; GABA Modulators; Huma | 2009 |
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU.
Topics: Adrenergic alpha-Agonists; Conscious Sedation; Critical Care; Dexmedetomidine; GABA Modulators; Huma | 2009 |
Comparing dexmedetomidine with midazolam for sedation of patients in the ICU.
Topics: Adrenergic alpha-Agonists; Conscious Sedation; Critical Care; Dexmedetomidine; GABA Modulators; Huma | 2009 |
Sedation improves early outcome in severely septic Sprague Dawley rats.
Topics: Animals; Blotting, Western; Caspase 3; Dexmedetomidine; Hypnotics and Sedatives; Interleukin-6; Male | 2009 |
Cardiac effects of induction agents in the septic rat heart.
Topics: Analgesics; Anesthetics, Intravenous; Animals; Cardiomyopathies; Dose-Response Relationship, Drug; G | 2009 |
Immunosedation: a consideration for sepsis.
Topics: Dexmedetomidine; Humans; Hypnotics and Sedatives; Immune System; Midazolam; Sepsis | 2009 |
Plasma fluoride concentrations during prolonged administration of isoflurane to a pediatric patient requiring renal replacement therapy.
Topics: Anesthetics, Inhalation; Child, Preschool; Conscious Sedation; Fentanyl; Fluorides; Humans; Hypnotic | 2012 |
Propofol depressed neutrophil hydrogen peroxide production more than midazolam, whereas adhesion molecule expression was minimally affected by both anesthetics in rats with abdominal sepsis.
Topics: Anesthetics, Intravenous; Animals; Hydrogen Peroxide; Integrin alphaXbeta2; Macrophage-1 Antigen; Ma | 2001 |