midazolam has been researched along with Obesity in 24 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In view of the increasing prevalence of obesity in adolescents, the aim of this study was to determine the pharmacokinetics of the CYP3A substrate midazolam and its metabolites in overweight and obese adolescents." | 7.81 | Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents. ( Barrett, JS; Knibbe, CA; Moorthy, GS; van den Anker, JN; van Rongen, A; Vaughns, JD, 2015) |
| "The effects of age, sex, and obesity on the kinetics of single intravenous (iv) and oral doses of midazolam were evaluated in healthy volunteers who received 2." | 7.67 | Effect of age, gender, and obesity on midazolam kinetics. ( Abernethy, DR; Greenblatt, DJ; Harmatz, JS; Limjuco, RA; Locniskar, A; Shader, RI, 1984) |
| " access, and blood sampling pain and stress affect hormone values, treatment with N(2)O or midazolam influence the glucose and stress hormone levels differently." | 5.16 | Effects of midazolam and nitrous oxide on endocrine and metabolic measurements in children. ( Ekbom, K; Jakobsson, J; Kalman, S; Marcus, C, 2012) |
| "In view of the increasing prevalence of obesity in adolescents, the aim of this study was to determine the pharmacokinetics of the CYP3A substrate midazolam and its metabolites in overweight and obese adolescents." | 3.81 | Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents. ( Barrett, JS; Knibbe, CA; Moorthy, GS; van den Anker, JN; van Rongen, A; Vaughns, JD, 2015) |
| "To investigate the relationship between total body weight (TBW) or body mass index (BMI) and atracurium reversal time." | 3.70 | Antagonism of atracurium-induced block in obese patients. ( Kirkegaard-Nielsen, H; Lindholm, P; Petersen, HS; Severinsen, IK, 1998) |
| " We have previously shown substantial intraindividual variability in midazolam absolute bioavailability and clearance in patients with obesity before and after weight loss induced by gastric bypass or a strict diet." | 1.91 | Intraindividual Variability in Absolute Bioavailability and Clearance of Midazolam in Healthy Individuals. ( Åsberg, A; Drevland, OM; Haugli, N; Kvitne, KE; Robertsen, I; Skadberg, E; Zaré, HK, 2023) |
| " Sedative and analgesic dosing was not clinically significantly higher in obese patients than in non-obese patients." | 1.43 | Sedation for Bronchoscopy and Complications in Obese Patients. ( Bellinger, CR; Chatterjee, AB; Haponik, E; Khan, I, 2016) |
| "The aim of this study is to assess the prevalence of sedation-related adverse events and the independent predictors of sedation requirements in RYGB patients." | 1.40 | Conscious sedation for upper endoscopy in the gastric bypass patient: prevalence of cardiopulmonary adverse events and predictors of sedation requirement. ( Abu Dayyeh, BK; Jirapinyo, P; Thompson, CC, 2014) |
| "40 of 79 patients (51%) developed hypoxemia, which occurred more frequently in the obese (71%; 10/14) than the nonobese (46%; 30/65) group (P=0." | 1.35 | Risk factors for hypoxemia during ambulatory gastrointestinal endoscopy in ASA I-II patients. ( Dumot, JA; Qadeer, MA; Rocio Lopez, A; Vargo, JJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.17) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 12 (50.00) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Kvitne, KE | 1 |
| Drevland, OM | 1 |
| Haugli, N | 1 |
| Skadberg, E | 1 |
| Zaré, HK | 1 |
| Åsberg, A | 1 |
| Robertsen, I | 1 |
| Verkerk, BS | 1 |
| Dzierba, AL | 1 |
| Muir, J | 1 |
| Der-Nigoghossian, C | 1 |
| Brodie, D | 1 |
| Bacchetta, M | 1 |
| Rietdijk, W | 1 |
| Bakker, J | 1 |
| Howie, GC | 1 |
| Ransford, N | 1 |
| Russell, SH | 1 |
| van Rongen, A | 2 |
| Brill, MJE | 1 |
| Vaughns, JD | 2 |
| Välitalo, PAJ | 1 |
| van Dongen, EPA | 1 |
| van Ramshorst, B | 1 |
| Barrett, JS | 2 |
| van den Anker, JN | 2 |
| Knibbe, CAJ | 1 |
| Horwitz, G | 1 |
| Roncari, D | 1 |
| Braaten, KP | 1 |
| Maurer, R | 1 |
| Fortin, J | 1 |
| Goldberg, AB | 1 |
| Döbrönte, Z | 1 |
| Szenes, M | 1 |
| Gasztonyi, B | 1 |
| Csermely, L | 1 |
| Kovács, M | 1 |
| Lakatos, L | 1 |
| Lakner, L | 1 |
| Mester, G | 1 |
| Pandur, T | 1 |
| Patai, A | 1 |
| Pák, P | 1 |
| Pécsi, G | 1 |
| Rácz, I | 1 |
| Sarang, K | 1 |
| Stöckert, A | 1 |
| Székely, A | 1 |
| Varga Szabó, L | 1 |
| Li, L | 1 |
| Feng, J | 1 |
| Xie, SH | 1 |
| Geng, LC | 1 |
| Jirapinyo, P | 1 |
| Abu Dayyeh, BK | 1 |
| Thompson, CC | 1 |
| Chan, LN | 1 |
| Lin, YS | 1 |
| Tay-Sontheimer, JC | 1 |
| Trawick, D | 1 |
| Oelschlager, BK | 1 |
| Flum, DR | 1 |
| Patton, KK | 1 |
| Shen, DD | 1 |
| Horn, JR | 1 |
| Moorthy, GS | 1 |
| Knibbe, CA | 1 |
| Khan, I | 1 |
| Chatterjee, AB | 1 |
| Bellinger, CR | 1 |
| Haponik, E | 1 |
| Qadeer, MA | 1 |
| Rocio Lopez, A | 1 |
| Dumot, JA | 1 |
| Vargo, JJ | 1 |
| Ekbom, K | 2 |
| Kalman, S | 2 |
| Jakobsson, J | 2 |
| Marcus, C | 2 |
| Ghose, R | 1 |
| Omoluabi, O | 1 |
| Gandhi, A | 1 |
| Shah, P | 1 |
| Strohacker, K | 1 |
| Carpenter, KC | 1 |
| McFarlin, B | 1 |
| Guo, T | 1 |
| Edelman, A | 1 |
| Munar, M | 1 |
| Elman, MR | 1 |
| Koop, D | 1 |
| Cherala, G | 1 |
| Compton, R | 1 |
| Spiller, HA | 1 |
| Bosse, GM | 1 |
| Cillo, JE | 1 |
| Finn, R | 1 |
| Greenblatt, DJ | 1 |
| Abernethy, DR | 1 |
| Locniskar, A | 1 |
| Harmatz, JS | 1 |
| Limjuco, RA | 1 |
| Shader, RI | 1 |
| Block, R | 1 |
| Jankowski, J | 1 |
| Johnston, D | 1 |
| Colvin, JR | 1 |
| Wormsley, KG | 1 |
| Smith, MR | 1 |
| Bell, GD | 1 |
| Kirkegaard-Nielsen, H | 1 |
| Lindholm, P | 1 |
| Petersen, HS | 1 |
| Severinsen, IK | 1 |
| Buczko, GB | 1 |
| Lindahl, SG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| High Flow Nasal Cannula (HFNC) Versus Standard Low Flow Nasal Cannula (LFNC) in Patients With Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation (RFCA) Under Deep Desaturation.[NCT04842253] | 210 participants (Anticipated) | Interventional | 2022-01-04 | Recruiting | |||
| Music Utilization in Sedation and Induction in Colonoscopy[NCT04468048] | 0 participants (Actual) | Observational | 2019-01-30 | Withdrawn (stopped due to No participants) | |||
| High-Flow Nasal Oxygenation Versus Standard Oxygenation in Gastrointestinal Endoscopy With Sedation. A Prospective Multicenter Randomized Study[NCT03829293] | 380 participants (Actual) | Interventional | 2019-03-26 | Completed | |||
| Effects of Clonidine and Midazolam Premedication on Bispectral Index and Recovery After Elective Surgery[NCT00638729] | 60 participants (Actual) | Interventional | 2005-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for midazolam and Obesity
| Article | Year |
|---|---|
Sedation in critically ill patients: a review.
Topics: Adult; Age Factors; Aged; Analgesics; Critical Illness; Electroencephalography; Humans; Hypnotics an | 2001 |
The use of midazolam in premedication.
Topics: Anxiety; Diazepam; Half-Life; Humans; Midazolam; Obesity; Postoperative Period; Preanesthetic Medica | 1990 |
4 trials available for midazolam and Obesity
| Article | Year |
|---|---|
Efficient intravenous access without distress: a double-blind randomized study of midazolam and nitrous oxide in children and adolescents.
Topics: Adolescent; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Anesthetics, Local; Chi-Square Distr | 2011 |
Effect of the ethinylestradiol/levonorgestrel combined oral contraceptive on the activity of cytochrome P4503A in obese women.
Topics: Adolescent; Adult; Chromatography, Liquid; Contraceptives, Oral, Combined; Cytochrome P-450 CYP3A; D | 2012 |
Effects of midazolam and nitrous oxide on endocrine and metabolic measurements in children.
Topics: Adolescent; Anesthetics, Local; Blood Glucose; Blood Specimen Collection; Catheterization, Periphera | 2012 |
The administration of supplementary oxygen to prevent hypoxia during upper alimentary endoscopy.
Topics: Costs and Cost Analysis; Diazepam; Endoscopy, Gastrointestinal; Female; Humans; Hypoxia; Male; Midaz | 1993 |
18 other studies available for midazolam and Obesity
| Article | Year |
|---|---|
Intraindividual Variability in Absolute Bioavailability and Clearance of Midazolam in Healthy Individuals.
Topics: Administration, Intravenous; Administration, Oral; Biological Availability; Cytochrome P-450 CYP3A; | 2023 |
Opioid and Benzodiazepine Requirements in Obese Adult Patients Receiving Extracorporeal Membrane Oxygenation.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Extracorporeal Membrane Oxygenation; Female; Fentanyl; H | 2020 |
Clinical considerations in providing intravenous sedation with midazolam for obese patients in dentistry.
Topics: Anesthesia, Dental; Capnography; Conscious Sedation; Humans; Hypnotics and Sedatives; Midazolam; Obe | 2021 |
Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults.
Topics: Administration, Intravenous; Adolescent; Adult; Child; Cytochrome P-450 CYP3A; Female; Humans; Hypno | 2018 |
Moderate intravenous sedation for first trimester surgical abortion: a comparison of adverse outcomes between obese and normal-weight women.
Topics: Abortion, Induced; Adolescent; Adult; Anesthetics, Intravenous; Body Mass Index; Child; Conscious Se | 2018 |
[Role of pulse oximetric monitoring during gastrointestinal endoscopy. Prospective multicenter study of the Gastroenterology Working Group of the Veszprém Regional Committee of the Hungarian Academy of Sciences (VEAB)].
Topics: Adjuvants, Anesthesia; Age Factors; Aged; Aged, 80 and over; Cardiovascular Diseases; Cholangiopancr | 2013 |
A chin-lift mask produces a patent airway more effectively than an oropharyngeal airway using the EC-clamp technique in obese patients.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Atracurium; Chin; Cholecystectomy; Cholecystit | 2014 |
Conscious sedation for upper endoscopy in the gastric bypass patient: prevalence of cardiopulmonary adverse events and predictors of sedation requirement.
Topics: Adult; Anesthetics, Intravenous; Arrhythmias, Cardiac; Body Mass Index; Conscious Sedation; Endoscop | 2014 |
Proximal Roux-en-Y gastric bypass alters drug absorption pattern but not systemic exposure of CYP3A4 and P-glycoprotein substrates.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Digoxin; Fem | 2015 |
Population pharmacokinetics of midazolam and its metabolites in overweight and obese adolescents.
Topics: Adolescent; Body Weight; Child; Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Models, Bi | 2015 |
Sedation for Bronchoscopy and Complications in Obese Patients.
Topics: Anesthetics, Intravenous; Body Mass Index; Bronchoscopy; Conscious Sedation; Female; Fentanyl; Human | 2016 |
Risk factors for hypoxemia during ambulatory gastrointestinal endoscopy in ASA I-II patients.
Topics: Age Factors; Aged; Ambulatory Surgical Procedures; Body Mass Index; Conscious Sedation; Dose-Respons | 2009 |
Risk factors for hypoxemia during ambulatory gastrointestinal endoscopy in ASA I-II patients.
Topics: Age Factors; Aged; Ambulatory Surgical Procedures; Body Mass Index; Conscious Sedation; Dose-Respons | 2009 |
Risk factors for hypoxemia during ambulatory gastrointestinal endoscopy in ASA I-II patients.
Topics: Age Factors; Aged; Ambulatory Surgical Procedures; Body Mass Index; Conscious Sedation; Dose-Respons | 2009 |
Risk factors for hypoxemia during ambulatory gastrointestinal endoscopy in ASA I-II patients.
Topics: Age Factors; Aged; Ambulatory Surgical Procedures; Body Mass Index; Conscious Sedation; Dose-Respons | 2009 |
Risk factors for hypoxemia during ambulatory gastrointestinal endoscopy in ASA I-II patients.
Topics: Age Factors; Aged; Ambulatory Surgical Procedures; Body Mass Index; Conscious Sedation; Dose-Respons | 2009 |
Risk factors for hypoxemia during ambulatory gastrointestinal endoscopy in ASA I-II patients.
Topics: Age Factors; Aged; Ambulatory Surgical Procedures; Body Mass Index; Conscious Sedation; Dose-Respons | 2009 |
Risk factors for hypoxemia during ambulatory gastrointestinal endoscopy in ASA I-II patients.
Topics: Age Factors; Aged; Ambulatory Surgical Procedures; Body Mass Index; Conscious Sedation; Dose-Respons | 2009 |
Risk factors for hypoxemia during ambulatory gastrointestinal endoscopy in ASA I-II patients.
Topics: Age Factors; Aged; Ambulatory Surgical Procedures; Body Mass Index; Conscious Sedation; Dose-Respons | 2009 |
Risk factors for hypoxemia during ambulatory gastrointestinal endoscopy in ASA I-II patients.
Topics: Age Factors; Aged; Ambulatory Surgical Procedures; Body Mass Index; Conscious Sedation; Dose-Respons | 2009 |
Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Arylsulfotransferase; Constitutive Androstane Receptor; Cyto | 2011 |
Fatal fluoxetine ingestion with postmortem blood concentrations.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Bradycardia; Child, Preschool; Dia | 2005 |
Correlation and comparison of body mass index on hemodynamics in hypertensive and normotensive patients undergoing intravenous sedation.
Topics: Adult; Anesthesia, Dental; Anesthetics, Intravenous; Blood Pressure; Body Mass Index; Conscious Seda | 2006 |
Effect of age, gender, and obesity on midazolam kinetics.
Topics: Administration, Oral; Adult; Age Factors; Aged; Anesthetics; Benzodiazepines; Female; Half-Life; Hum | 1984 |
Routine oxygen during endoscopy? An editorial review.
Topics: Costs and Cost Analysis; Diazepam; Endoscopy, Gastrointestinal; Humans; Hypoxia; Midazolam; Obesity; | 1993 |
Antagonism of atracurium-induced block in obese patients.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Atracurium; Body Mass Index; Body Weight; | 1998 |