midazolam has been researched along with Malaria in 4 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe the first systematic study of antimalarial 1,2,4-trioxolanes bearing a substitution pattern regioisomeric to that of arterolane." | 7.85 | Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. ( Blank, BR; Gut, J; Renslo, AR; Rosenthal, PJ, 2017) |
| "We describe the first systematic study of antimalarial 1,2,4-trioxolanes bearing a substitution pattern regioisomeric to that of arterolane." | 3.85 | Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. ( Blank, BR; Gut, J; Renslo, AR; Rosenthal, PJ, 2017) |
| "In a previous study, the efficacy and safety of buccal midazolam was compared to that of rectal diazepam in the treatment of prolonged seizures in children aged three months to 12 years in Kampala, Uganda." | 3.75 | Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda. ( Byarugaba, J; Mpimbaza, A; Ndeezi, G; Rosenthal, PJ; Staedke, SG, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, K | 1 |
| Okombo, J | 2 |
| Brunschwig, C | 1 |
| Ndubi, F | 1 |
| Barnard, L | 1 |
| Wilkinson, C | 1 |
| Njogu, PM | 1 |
| Njoroge, M | 1 |
| Laing, L | 1 |
| Machado, M | 1 |
| Prudêncio, M | 1 |
| Reader, J | 1 |
| Botha, M | 1 |
| Nondaba, S | 1 |
| Birkholtz, LM | 1 |
| Lauterbach, S | 1 |
| Churchyard, A | 1 |
| Coetzer, TL | 1 |
| Burrows, JN | 1 |
| Yeates, C | 1 |
| Denti, P | 1 |
| Wiesner, L | 2 |
| Egan, TJ | 2 |
| Wittlin, S | 1 |
| Chibale, K | 2 |
| Blank, BR | 1 |
| Gut, J | 1 |
| Rosenthal, PJ | 2 |
| Renslo, AR | 1 |
| Joshi, MC | 1 |
| Nsumiwa, S | 1 |
| Ndove, J | 1 |
| Taylor, D | 1 |
| Hunter, R | 1 |
| Mpimbaza, A | 1 |
| Staedke, SG | 1 |
| Ndeezi, G | 1 |
| Byarugaba, J | 1 |
4 other studies available for midazolam and Malaria
| Article | Year |
|---|---|
Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model.
Topics: Animals; Antimalarials; Benzimidazoles; Life Cycle Stages; Malaria; Male; Mice; Plasmodium berghei; | 2017 |
Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane.
Topics: Animals; Antimalarials; Female; Ferrous Compounds; Heterocyclic Compounds, 1-Ring; Malaria; Mice; Pe | 2017 |
4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice.
Topics: Administration, Oral; Aminopyridines; Aminoquinolines; Animals; Antimalarials; Cell Membrane Permeab | 2017 |
Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Malaria; Male; Midazolam | 2009 |