midazolam and Cough
midazolam has been researched along with Cough in 28 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Compared with midazolam, dexmedetomidine is an effective alternative to attenuate coughing and hemodynamic changes with a low incidence of adverse events during emergence from anesthesia after partial and total laryngectomy." | 9.34 | Dexmedetomidine versus midazolam on cough and recovery quality after partial and total laryngectomy - a randomized controlled trial. ( Jia, J; Li, W; Lu, Y; Xu, R; Zhu, Y, 2020) |
| "The group that was premedicated with dextromethorphan had lower complaint scores, significantly less coughing, significantly less stress assessed by the patient and the physician evaluation, shorter total procedure time, and fewer midazolam requirements during FB (P-value <0." | 9.24 | The Effect of Dextromethorphan Premedication on Cough and Patient Tolerance During Flexible Bronchoscopy: A Randomized, Double-blind, Placebo-controlled Trial. ( Amini, S; Ghalamkari, M; Khatuni, M; Peiman, S; Rahimi, B, 2017) |
| "The incidence of fentanyl-induced cough (FIC) occurs frequently during induction of general anesthesia, and methods to prevent it are needed." | 9.16 | Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough. ( Dong, C; Lu, Y; Xu, R; Yu, J; Zhu, H, 2012) |
| "The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed." | 9.11 | Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trial. ( Brutsche, M; Chhajed, PN; Leuppi, JD; Pflimlin, E; Stolz, D; Tamm, M, 2004) |
| "To evaluate the efficacy of continuous administration of 50% nitrous oxide in oxygen for reducing pain during flexible fiberoptic bronchoscopy 32 children aged 3-60 months were randomly assigned to an experimental or a control group." | 9.08 | [Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination]. ( Dupont, D; Garcia, J; Hayem, C; Roure, P, 1998) |
| "Propofol 2 mg x kg(-1) was superior to thiopentone 6 mg x kg(-1) and etomidate 0." | 6.71 | Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade. ( Alper, I; Erhan, E; Gunusen, I; Ozyar, B; Ugur, G, 2003) |
| "Compared with midazolam, dexmedetomidine is an effective alternative to attenuate coughing and hemodynamic changes with a low incidence of adverse events during emergence from anesthesia after partial and total laryngectomy." | 5.34 | Dexmedetomidine versus midazolam on cough and recovery quality after partial and total laryngectomy - a randomized controlled trial. ( Jia, J; Li, W; Lu, Y; Xu, R; Zhu, Y, 2020) |
| "The group that was premedicated with dextromethorphan had lower complaint scores, significantly less coughing, significantly less stress assessed by the patient and the physician evaluation, shorter total procedure time, and fewer midazolam requirements during FB (P-value <0." | 5.24 | The Effect of Dextromethorphan Premedication on Cough and Patient Tolerance During Flexible Bronchoscopy: A Randomized, Double-blind, Placebo-controlled Trial. ( Amini, S; Ghalamkari, M; Khatuni, M; Peiman, S; Rahimi, B, 2017) |
| "The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed." | 5.11 | Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trial. ( Brutsche, M; Chhajed, PN; Leuppi, JD; Pflimlin, E; Stolz, D; Tamm, M, 2004) |
| "To evaluate the efficacy of continuous administration of 50% nitrous oxide in oxygen for reducing pain during flexible fiberoptic bronchoscopy 32 children aged 3-60 months were randomly assigned to an experimental or a control group." | 5.08 | [Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination]. ( Dupont, D; Garcia, J; Hayem, C; Roure, P, 1998) |
| "The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl." | 5.07 | Tussive effect of a fentanyl bolus. ( Jong, W; Lee, TL; Phua, WT; Teh, BT; Tweed, WA, 1991) |
| " Cough was not different between the nebulized lidocaine group and no nebulized lidocaine group (SMD, -0." | 5.05 | Is Additional Nebulized Lidocaine Helpful in Flexible Bronchoscopy?: A Meta-Analysis. ( Gandhiraj, D; Ho, ATN; Jamkhana, Z; Nayak, R; Patolia, S, 2020) |
| "To add to the evidence base for safe and effective paediatric conscious sedation techniques in primary dental care." | 2.76 | The safety and efficacy of using a concentrated intranasal midazolam formulation for paediatric dental sedation. ( Wood, M, 2011) |
| " As compared with 4% lidocaine, however, 2% lidocaine requires a smaller dosage and results in lower plasma concentrations." | 2.74 | Spray-as-you-go airway topical anesthesia in patients with a difficult airway: a randomized, double-blind comparison of 2% and 4% lidocaine. ( Guo, XL; He, N; Liao, X; Liu, HP; Xu, XZ; Xu, YC; Xue, FS; Yang, QY; Zhang, YM, 2009) |
| "The present study was undertaken to evaluate Midazolam as a Paediatric conscious sedative agent for a routine Indian dental setup and to compare its efficacy and safety when administered by intranasal and intramuscular routes, at a dosage of 0." | 2.72 | Conscious sedation--an artist's science! An Indian experience with midazolam. ( Reddy, SV; Shashikiran, ND; Yavagal, CM, 2006) |
| "Propofol 2 mg x kg(-1) was superior to thiopentone 6 mg x kg(-1) and etomidate 0." | 2.71 | Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade. ( Alper, I; Erhan, E; Gunusen, I; Ozyar, B; Ugur, G, 2003) |
| "Isoflurane was compared with sevoflurane in terms of rapidity, efficacy, safety and acceptability of induction." | 2.69 | Single vital capacity inhalational anaesthetic induction in adults--isoflurane vs sevoflurane. ( Lee, TL; Pua, HL; Ti, LK, 1998) |
| "Alfentanil is a more effective anti-tussive agent than midazolam for outpatient fibre optic bronchoscopy." | 2.68 | Sedation for fibre optic bronchoscopy. ( Cooper, SM; Fennerty, AG; Greig, JH; Kasimbazi, HJ; Monie, RD; Watson, B, 1995) |
| "The incidence of gagging (P = 0." | 2.68 | Comparison of propofol versus thiopentone with midazolam or lidocaine to facilitate laryngeal mask insertion. ( Bapat, P; Jago, RH; Joshi, RN; Young, E, 1996) |
| "The etiology of the acutely developed atelectasis was unclear." | 1.34 | Pulmonary atelectasis manifested after induction of anesthesia: a contribution of sinobronchial syndrome? ( Amagasa, S; Igarashi, A; Oda, S; Yokoo, N, 2007) |
| "We report our experience of venous air embolism in three small children during placement of tunneled central venous catheters when GA was not used." | 1.30 | Air embolism during tunneled central catheter placement performed without general anesthesia in children: a potentially serious complication. ( Donaldson, JS; Morello, FP; Norman, JT; Saker, MC, 1999) |
Research
Studies (28)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 7 (25.00) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sirohiya, P | 1 |
| Kumar, V | 1 |
| Mittal, S | 1 |
| Gupta, N | 1 |
| Garg, R | 1 |
| Bharati, SJ | 1 |
| Mishra, S | 1 |
| Hadda, V | 1 |
| Mohan, A | 1 |
| Sagiraju, HKR | 1 |
| Bhatnagar, S | 1 |
| Madan, K | 1 |
| Ho, ATN | 1 |
| Gandhiraj, D | 1 |
| Jamkhana, Z | 1 |
| Nayak, R | 1 |
| Patolia, S | 1 |
| Xu, R | 2 |
| Zhu, Y | 1 |
| Lu, Y | 3 |
| Li, W | 1 |
| Jia, J | 1 |
| Amini, S | 1 |
| Peiman, S | 1 |
| Khatuni, M | 1 |
| Ghalamkari, M | 1 |
| Rahimi, B | 1 |
| Hanamoto, H | 1 |
| Sugimura, M | 1 |
| Morimoto, Y | 1 |
| Kudo, C | 1 |
| Boku, A | 1 |
| Niwa, H | 1 |
| Yu, JM | 1 |
| Dong, CS | 1 |
| Zhu, HJ | 1 |
| Xu, RH | 1 |
| Gelberg, J | 1 |
| Kongstad, L | 1 |
| Werner, O | 1 |
| Xue, FS | 1 |
| Liu, HP | 1 |
| He, N | 1 |
| Xu, YC | 1 |
| Yang, QY | 1 |
| Liao, X | 1 |
| Xu, XZ | 1 |
| Guo, XL | 1 |
| Zhang, YM | 1 |
| Wood, M | 1 |
| Yu, J | 1 |
| Dong, C | 1 |
| Zhu, H | 1 |
| Lawlor, DA | 1 |
| Chaudhri, R | 1 |
| Shannon, J | 1 |
| Erhan, E | 1 |
| Ugur, G | 1 |
| Gunusen, I | 1 |
| Alper, I | 1 |
| Ozyar, B | 1 |
| Trabold, F | 1 |
| Casetta, M | 1 |
| Duranteau, J | 1 |
| Albaladejo, P | 1 |
| Mazoit, JX | 1 |
| Samii, K | 1 |
| Benhamou, D | 1 |
| Sitbon, P | 1 |
| Okazaki, J | 1 |
| Isono, S | 1 |
| Hasegawa, H | 1 |
| Sakai, M | 1 |
| Nagase, Y | 1 |
| Nishino, T | 1 |
| Stolz, D | 1 |
| Chhajed, PN | 1 |
| Leuppi, JD | 1 |
| Brutsche, M | 1 |
| Pflimlin, E | 1 |
| Tamm, M | 1 |
| Houghton, CM | 1 |
| Raghuram, A | 1 |
| Sullivan, PJ | 1 |
| O'Driscoll, R | 1 |
| Shashikiran, ND | 1 |
| Reddy, SV | 1 |
| Yavagal, CM | 1 |
| Igarashi, A | 1 |
| Amagasa, S | 1 |
| Oda, S | 1 |
| Yokoo, N | 1 |
| Stamenkovic, DM | 1 |
| Hassid, M | 1 |
| Greig, JH | 1 |
| Cooper, SM | 1 |
| Kasimbazi, HJ | 1 |
| Monie, RD | 1 |
| Fennerty, AG | 1 |
| Watson, B | 1 |
| Bapat, P | 1 |
| Joshi, RN | 1 |
| Young, E | 1 |
| Jago, RH | 1 |
| Sanderson, PM | 1 |
| Garcia, J | 1 |
| Roure, P | 1 |
| Hayem, C | 1 |
| Dupont, D | 1 |
| Ti, LK | 1 |
| Pua, HL | 1 |
| Lee, TL | 2 |
| Morello, FP | 1 |
| Donaldson, JS | 1 |
| Saker, MC | 1 |
| Norman, JT | 1 |
| Silverman, SM | 1 |
| Culling, RD | 1 |
| Middaugh, RE | 1 |
| Phua, WT | 1 |
| Teh, BT | 1 |
| Jong, W | 1 |
| Tweed, WA | 1 |
| Mendes de Leon, C | 1 |
| Bezel, R | 1 |
| Karrer, W | 1 |
| Brändli, O | 1 |
Clinical Trials (4)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial of the Effect of Dexmedetomidine Compared With Midazolam on Airway Reflex and Recovery Quality During Emergence From General Anesthesia After Partial and Total Laryngectomy[NCT03918889] | 120 participants (Anticipated) | Interventional | 2019-05-01 | Enrolling by invitation | |||
| Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound[NCT03829618] | Phase 3 | 29 participants (Actual) | Interventional | 2019-04-01 | Terminated (stopped due to COVID lack of cases/recruitment) | ||
| Deep Sedation and General Anesthesia for Endoscopic Retrograde Cholangiopancreatography[NCT04087668] | 405 participants (Actual) | Interventional | 2019-09-01 | Completed | |||
| Safety and Efficacy of Sedation for Flexible Fiberoptic Bronchoscopy: Comparison of Propofol/Alfentanil With Propofol/Ketamine[NCT02000206] | 80 participants (Anticipated) | Interventional | 2014-02-28 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Alfentanyl Dosing
Total alfentanyl dosing by anesthesia in mcg/kg (NCT03829618)
Timeframe: 1 day
| Intervention | mcg/kg (Mean) |
|---|---|
| Topical Lidocaine | 16.61 |
| Nebuliser Solution | 47.99 |
| Atomizer Solution | 4.40 |
Anesthesia Time to Wake up
time in minutes from scope out until ready for transport to post anesthesia care unit (NCT03829618)
Timeframe: 1 day
| Intervention | minutes (Mean) |
|---|---|
| Topical Lidocaine | 8.47 |
| Nebuliser Solution | 13.00 |
| Atomizer Solution | 6.14 |
Cough
Number of coughs during procedure as defined by cough requiring stopping procedure or treatment by anesthesiologist with propofol or alfentanyl (NCT03829618)
Timeframe: 1 day
| Intervention | coughs (Mean) |
|---|---|
| Topical Lidocaine | 1.20 |
| Nebuliser Solution | 1.71 |
| Atomizer Solution | 1.00 |
Fentanyl Dosing
total fentanyl dosing by anesthesia in mcg/kg (NCT03829618)
Timeframe: 1 day
| Intervention | mcg/kg (Mean) |
|---|---|
| Topical Lidocaine | 0.30 |
| Nebuliser Solution | 0.24 |
| Atomizer Solution | 0.48 |
Propofol Dosing
Total propofol dosing by anesthesia in mg/kg (NCT03829618)
Timeframe: 1 day
| Intervention | mg/kg (Mean) |
|---|---|
| Topical Lidocaine | 5.30 |
| Nebuliser Solution | 6.93 |
| Atomizer Solution | 3.26 |
Reviews
1 review available for midazolam and Cough
| Article | Year |
|---|---|
Is Additional Nebulized Lidocaine Helpful in Flexible Bronchoscopy?: A Meta-Analysis.
Topics: Adjuvants, Anesthesia; Adult; Aged; Anesthetics, Local; Bronchoscopy; Case-Control Studies; Consciou | 2020 |
Trials
19 trials available for midazolam and Cough
| Article | Year |
|---|---|
Dexmedetomidine Versus Midazolam for Sedation During Medical Thoracoscopy: A Pilot Randomized-Controlled Trial (RCT).
Topics: Analgesics, Opioid; Conscious Sedation; Cough; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Seda | 2022 |
Dexmedetomidine versus midazolam on cough and recovery quality after partial and total laryngectomy - a randomized controlled trial.
Topics: Adult; Aged; Anesthesia Recovery Period; Cough; Dexmedetomidine; Double-Blind Method; Humans; Hypnot | 2020 |
The Effect of Dextromethorphan Premedication on Cough and Patient Tolerance During Flexible Bronchoscopy: A Randomized, Double-blind, Placebo-controlled Trial.
Topics: Analgesics; Anesthetics, Local; Anti-Anxiety Agents; Antitussive Agents; Anxiety; Bronchoscopy; Coug | 2017 |
Intubation conditions in young infants after propofol and remifentanil induction with and without low-dose rocuronium.
Topics: Androstanols; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Cough; | 2014 |
Spray-as-you-go airway topical anesthesia in patients with a difficult airway: a randomized, double-blind comparison of 2% and 4% lidocaine.
Topics: Adult; Aerosols; Anesthesia, Inhalation; Anesthetics, Local; Blood Pressure; Cough; Double-Blind Met | 2009 |
The safety and efficacy of using a concentrated intranasal midazolam formulation for paediatric dental sedation.
Topics: Administration, Intranasal; Adolescent; Anesthesia, Dental; Anesthetics, Local; Child; Child Behavio | 2011 |
Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Cough; Dexmedetomidine; Drug Combinations; Female | 2012 |
Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade.
Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Intravenous; Blood Pressure; Cough; Double-Blind | 2003 |
Propofol and remifentanil for intubation without muscle relaxant: the effect of the order of injection.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Blood Pressure; Cough; Female; Heart Rate; Humans; Hypn | 2004 |
Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trial.
Topics: Antitussive Agents; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cough; Double-Blind Method; Drug The | 2004 |
Pre-medication for bronchoscopy: a randomised double blind trial comparing alfentanil with midazolam.
Topics: Alfentanil; Analgesics, Opioid; Anti-Anxiety Agents; Bronchoscopy; Cough; Double-Blind Method; Human | 2004 |
Conscious sedation--an artist's science! An Indian experience with midazolam.
Topics: Administration, Intranasal; Anesthesia Recovery Period; Anesthesia, Dental; Body Weight; Child Behav | 2006 |
Sedation for fibre optic bronchoscopy.
Topics: Alfentanil; Bronchoscopy; Conscious Sedation; Cough; Double-Blind Method; Drug Therapy, Combination; | 1995 |
Comparison of propofol versus thiopentone with midazolam or lidocaine to facilitate laryngeal mask insertion.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Cough; Drug Costs; Elective Surgical Procedures | 1996 |
[Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination].
Topics: Adjuvants, Anesthesia; Administration, Rectal; Anesthesia, Local; Anesthetics, Inhalation; Anestheti | 1998 |
Single vital capacity inhalational anaesthetic induction in adults--isoflurane vs sevoflurane.
Topics: Adolescent; Adult; Anesthesia, Closed-Circuit; Anesthesia, Inhalation; Anesthetics, Inhalation; Coug | 1998 |
Rapid-sequence orotracheal intubation: a comparison of three techniques.
Topics: Abdomen; Adolescent; Adult; Aged; Cough; Electric Stimulation; Humans; Intubation, Intratracheal; Mi | 1990 |
Tussive effect of a fentanyl bolus.
Topics: Adult; Analysis of Variance; Anesthesia, Intravenous; Atropine; Blood Pressure; Cough; Double-Blind | 1991 |
[Premedication in fiber optic bronchoscopy from the patient's and the physician's viewpoint--a randomized study for the comparison of midazolam and hydrocodone].
Topics: Adult; Aged; Bronchoscopy; Codeine; Consumer Behavior; Cough; Dyspnea; Female; Fiber Optic Technolog | 1986 |
Other Studies
8 other studies available for midazolam and Cough
| Article | Year |
|---|---|
Cough reflex under intravenous sedation during dental implant surgery is more frequent during procedures in the maxillary anterior region.
Topics: Aged; Anesthesia, Dental; Anesthesia, Intravenous; Chi-Square Distribution; Conscious Sedation; Coug | 2013 |
Effect of intravenous dexmedetomidine-midazolam on fentanyl-induced cough.
Topics: Anesthetics, Intravenous; Cough; Dexmedetomidine; Female; Humans; Male; Midazolam; Preanesthetic Med | 2014 |
Fentanyl-induced cough during general anesthesia: a different perspective.
Topics: Anesthetics, Intravenous; Cough; Dexmedetomidine; Female; Humans; Male; Midazolam; Preanesthetic Med | 2013 |
Quantitative assessment of tracheal collapsibility in infants with tracheomalacia.
Topics: Airway Resistance; Anesthesia, General; Body Weight; Bronchoscopy; Case-Control Studies; Compliance; | 2004 |
Pulmonary atelectasis manifested after induction of anesthesia: a contribution of sinobronchial syndrome?
Topics: Adult; Airway Obstruction; Analgesics, Opioid; Anesthesia, General; Anesthetics, Intravenous; Blood | 2007 |
Innovative uses of dexmedetomidine.
Topics: Analgesics, Non-Narcotic; Anesthetics, Intravenous; Cough; Dexmedetomidine; Fiber Optic Technology; | 2007 |
A survey of pentobarbital sedation for children undergoing abdominal CT scans after oral contrast medium.
Topics: Adjuvants, Anesthesia; Administration, Oral; Airway Obstruction; Anesthesiology; Bronchial Spasm; Ch | 1997 |
Air embolism during tunneled central catheter placement performed without general anesthesia in children: a potentially serious complication.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Catheterization, Central Venous; Catheters, Ind | 1999 |