Page last updated: 2024-10-31

midazolam and Cough

midazolam has been researched along with Cough in 28 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"Compared with midazolam, dexmedetomidine is an effective alternative to attenuate coughing and hemodynamic changes with a low incidence of adverse events during emergence from anesthesia after partial and total laryngectomy."9.34Dexmedetomidine versus midazolam on cough and recovery quality after partial and total laryngectomy - a randomized controlled trial. ( Jia, J; Li, W; Lu, Y; Xu, R; Zhu, Y, 2020)
"The group that was premedicated with dextromethorphan had lower complaint scores, significantly less coughing, significantly less stress assessed by the patient and the physician evaluation, shorter total procedure time, and fewer midazolam requirements during FB (P-value <0."9.24The Effect of Dextromethorphan Premedication on Cough and Patient Tolerance During Flexible Bronchoscopy: A Randomized, Double-blind, Placebo-controlled Trial. ( Amini, S; Ghalamkari, M; Khatuni, M; Peiman, S; Rahimi, B, 2017)
"The incidence of fentanyl-induced cough (FIC) occurs frequently during induction of general anesthesia, and methods to prevent it are needed."9.16Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough. ( Dong, C; Lu, Y; Xu, R; Yu, J; Zhu, H, 2012)
"The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed."9.11Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trial. ( Brutsche, M; Chhajed, PN; Leuppi, JD; Pflimlin, E; Stolz, D; Tamm, M, 2004)
"To evaluate the efficacy of continuous administration of 50% nitrous oxide in oxygen for reducing pain during flexible fiberoptic bronchoscopy 32 children aged 3-60 months were randomly assigned to an experimental or a control group."9.08[Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination]. ( Dupont, D; Garcia, J; Hayem, C; Roure, P, 1998)
"Propofol 2 mg x kg(-1) was superior to thiopentone 6 mg x kg(-1) and etomidate 0."6.71Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade. ( Alper, I; Erhan, E; Gunusen, I; Ozyar, B; Ugur, G, 2003)
"Compared with midazolam, dexmedetomidine is an effective alternative to attenuate coughing and hemodynamic changes with a low incidence of adverse events during emergence from anesthesia after partial and total laryngectomy."5.34Dexmedetomidine versus midazolam on cough and recovery quality after partial and total laryngectomy - a randomized controlled trial. ( Jia, J; Li, W; Lu, Y; Xu, R; Zhu, Y, 2020)
"The group that was premedicated with dextromethorphan had lower complaint scores, significantly less coughing, significantly less stress assessed by the patient and the physician evaluation, shorter total procedure time, and fewer midazolam requirements during FB (P-value <0."5.24The Effect of Dextromethorphan Premedication on Cough and Patient Tolerance During Flexible Bronchoscopy: A Randomized, Double-blind, Placebo-controlled Trial. ( Amini, S; Ghalamkari, M; Khatuni, M; Peiman, S; Rahimi, B, 2017)
"The combination of midazolam and hydrocodone markedly reduces cough during FB without causing significant desaturation, especially when invasive diagnostic procedures are performed."5.11Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trial. ( Brutsche, M; Chhajed, PN; Leuppi, JD; Pflimlin, E; Stolz, D; Tamm, M, 2004)
"To evaluate the efficacy of continuous administration of 50% nitrous oxide in oxygen for reducing pain during flexible fiberoptic bronchoscopy 32 children aged 3-60 months were randomly assigned to an experimental or a control group."5.08[Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination]. ( Dupont, D; Garcia, J; Hayem, C; Roure, P, 1998)
"The aim of this study was to investigate the incidence of pre-induction coughing, after an iv bolus of fentanyl."5.07Tussive effect of a fentanyl bolus. ( Jong, W; Lee, TL; Phua, WT; Teh, BT; Tweed, WA, 1991)
" Cough was not different between the nebulized lidocaine group and no nebulized lidocaine group (SMD, -0."5.05Is Additional Nebulized Lidocaine Helpful in Flexible Bronchoscopy?: A Meta-Analysis. ( Gandhiraj, D; Ho, ATN; Jamkhana, Z; Nayak, R; Patolia, S, 2020)
"To add to the evidence base for safe and effective paediatric conscious sedation techniques in primary dental care."2.76The safety and efficacy of using a concentrated intranasal midazolam formulation for paediatric dental sedation. ( Wood, M, 2011)
" As compared with 4% lidocaine, however, 2% lidocaine requires a smaller dosage and results in lower plasma concentrations."2.74Spray-as-you-go airway topical anesthesia in patients with a difficult airway: a randomized, double-blind comparison of 2% and 4% lidocaine. ( Guo, XL; He, N; Liao, X; Liu, HP; Xu, XZ; Xu, YC; Xue, FS; Yang, QY; Zhang, YM, 2009)
"The present study was undertaken to evaluate Midazolam as a Paediatric conscious sedative agent for a routine Indian dental setup and to compare its efficacy and safety when administered by intranasal and intramuscular routes, at a dosage of 0."2.72Conscious sedation--an artist's science! An Indian experience with midazolam. ( Reddy, SV; Shashikiran, ND; Yavagal, CM, 2006)
"Propofol 2 mg x kg(-1) was superior to thiopentone 6 mg x kg(-1) and etomidate 0."2.71Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade. ( Alper, I; Erhan, E; Gunusen, I; Ozyar, B; Ugur, G, 2003)
"Isoflurane was compared with sevoflurane in terms of rapidity, efficacy, safety and acceptability of induction."2.69Single vital capacity inhalational anaesthetic induction in adults--isoflurane vs sevoflurane. ( Lee, TL; Pua, HL; Ti, LK, 1998)
"Alfentanil is a more effective anti-tussive agent than midazolam for outpatient fibre optic bronchoscopy."2.68Sedation for fibre optic bronchoscopy. ( Cooper, SM; Fennerty, AG; Greig, JH; Kasimbazi, HJ; Monie, RD; Watson, B, 1995)
"The incidence of gagging (P = 0."2.68Comparison of propofol versus thiopentone with midazolam or lidocaine to facilitate laryngeal mask insertion. ( Bapat, P; Jago, RH; Joshi, RN; Young, E, 1996)
"The etiology of the acutely developed atelectasis was unclear."1.34Pulmonary atelectasis manifested after induction of anesthesia: a contribution of sinobronchial syndrome? ( Amagasa, S; Igarashi, A; Oda, S; Yokoo, N, 2007)
"We report our experience of venous air embolism in three small children during placement of tunneled central venous catheters when GA was not used."1.30Air embolism during tunneled central catheter placement performed without general anesthesia in children: a potentially serious complication. ( Donaldson, JS; Morello, FP; Norman, JT; Saker, MC, 1999)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.57)18.7374
1990's8 (28.57)18.2507
2000's9 (32.14)29.6817
2010's7 (25.00)24.3611
2020's3 (10.71)2.80

Authors

AuthorsStudies
Sirohiya, P1
Kumar, V1
Mittal, S1
Gupta, N1
Garg, R1
Bharati, SJ1
Mishra, S1
Hadda, V1
Mohan, A1
Sagiraju, HKR1
Bhatnagar, S1
Madan, K1
Ho, ATN1
Gandhiraj, D1
Jamkhana, Z1
Nayak, R1
Patolia, S1
Xu, R2
Zhu, Y1
Lu, Y3
Li, W1
Jia, J1
Amini, S1
Peiman, S1
Khatuni, M1
Ghalamkari, M1
Rahimi, B1
Hanamoto, H1
Sugimura, M1
Morimoto, Y1
Kudo, C1
Boku, A1
Niwa, H1
Yu, JM1
Dong, CS1
Zhu, HJ1
Xu, RH1
Gelberg, J1
Kongstad, L1
Werner, O1
Xue, FS1
Liu, HP1
He, N1
Xu, YC1
Yang, QY1
Liao, X1
Xu, XZ1
Guo, XL1
Zhang, YM1
Wood, M1
Yu, J1
Dong, C1
Zhu, H1
Lawlor, DA1
Chaudhri, R1
Shannon, J1
Erhan, E1
Ugur, G1
Gunusen, I1
Alper, I1
Ozyar, B1
Trabold, F1
Casetta, M1
Duranteau, J1
Albaladejo, P1
Mazoit, JX1
Samii, K1
Benhamou, D1
Sitbon, P1
Okazaki, J1
Isono, S1
Hasegawa, H1
Sakai, M1
Nagase, Y1
Nishino, T1
Stolz, D1
Chhajed, PN1
Leuppi, JD1
Brutsche, M1
Pflimlin, E1
Tamm, M1
Houghton, CM1
Raghuram, A1
Sullivan, PJ1
O'Driscoll, R1
Shashikiran, ND1
Reddy, SV1
Yavagal, CM1
Igarashi, A1
Amagasa, S1
Oda, S1
Yokoo, N1
Stamenkovic, DM1
Hassid, M1
Greig, JH1
Cooper, SM1
Kasimbazi, HJ1
Monie, RD1
Fennerty, AG1
Watson, B1
Bapat, P1
Joshi, RN1
Young, E1
Jago, RH1
Sanderson, PM1
Garcia, J1
Roure, P1
Hayem, C1
Dupont, D1
Ti, LK1
Pua, HL1
Lee, TL2
Morello, FP1
Donaldson, JS1
Saker, MC1
Norman, JT1
Silverman, SM1
Culling, RD1
Middaugh, RE1
Phua, WT1
Teh, BT1
Jong, W1
Tweed, WA1
Mendes de Leon, C1
Bezel, R1
Karrer, W1
Brändli, O1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Controlled Trial of the Effect of Dexmedetomidine Compared With Midazolam on Airway Reflex and Recovery Quality During Emergence From General Anesthesia After Partial and Total Laryngectomy[NCT03918889]120 participants (Anticipated)Interventional2019-05-01Enrolling by invitation
Lidocaine Administration During Flexible Bronchoscopy and Endobronchial Ultrasound[NCT03829618]Phase 329 participants (Actual)Interventional2019-04-01Terminated (stopped due to COVID lack of cases/recruitment)
Deep Sedation and General Anesthesia for Endoscopic Retrograde Cholangiopancreatography[NCT04087668]405 participants (Actual)Interventional2019-09-01Completed
Safety and Efficacy of Sedation for Flexible Fiberoptic Bronchoscopy: Comparison of Propofol/Alfentanil With Propofol/Ketamine[NCT02000206]80 participants (Anticipated)Interventional2014-02-28Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Alfentanyl Dosing

Total alfentanyl dosing by anesthesia in mcg/kg (NCT03829618)
Timeframe: 1 day

Interventionmcg/kg (Mean)
Topical Lidocaine16.61
Nebuliser Solution47.99
Atomizer Solution4.40

Anesthesia Time to Wake up

time in minutes from scope out until ready for transport to post anesthesia care unit (NCT03829618)
Timeframe: 1 day

Interventionminutes (Mean)
Topical Lidocaine8.47
Nebuliser Solution13.00
Atomizer Solution6.14

Cough

Number of coughs during procedure as defined by cough requiring stopping procedure or treatment by anesthesiologist with propofol or alfentanyl (NCT03829618)
Timeframe: 1 day

Interventioncoughs (Mean)
Topical Lidocaine1.20
Nebuliser Solution1.71
Atomizer Solution1.00

Fentanyl Dosing

total fentanyl dosing by anesthesia in mcg/kg (NCT03829618)
Timeframe: 1 day

Interventionmcg/kg (Mean)
Topical Lidocaine0.30
Nebuliser Solution0.24
Atomizer Solution0.48

Propofol Dosing

Total propofol dosing by anesthesia in mg/kg (NCT03829618)
Timeframe: 1 day

Interventionmg/kg (Mean)
Topical Lidocaine5.30
Nebuliser Solution6.93
Atomizer Solution3.26

Reviews

1 review available for midazolam and Cough

ArticleYear
Is Additional Nebulized Lidocaine Helpful in Flexible Bronchoscopy?: A Meta-Analysis.
    Journal of bronchology & interventional pulmonology, 2020, Volume: 27, Issue:4

    Topics: Adjuvants, Anesthesia; Adult; Aged; Anesthetics, Local; Bronchoscopy; Case-Control Studies; Consciou

2020

Trials

19 trials available for midazolam and Cough

ArticleYear
Dexmedetomidine Versus Midazolam for Sedation During Medical Thoracoscopy: A Pilot Randomized-Controlled Trial (RCT).
    Journal of bronchology & interventional pulmonology, 2022, Oct-01, Volume: 29, Issue:4

    Topics: Analgesics, Opioid; Conscious Sedation; Cough; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Seda

2022
Dexmedetomidine versus midazolam on cough and recovery quality after partial and total laryngectomy - a randomized controlled trial.
    BMC anesthesiology, 2020, 09-28, Volume: 20, Issue:1

    Topics: Adult; Aged; Anesthesia Recovery Period; Cough; Dexmedetomidine; Double-Blind Method; Humans; Hypnot

2020
The Effect of Dextromethorphan Premedication on Cough and Patient Tolerance During Flexible Bronchoscopy: A Randomized, Double-blind, Placebo-controlled Trial.
    Journal of bronchology & interventional pulmonology, 2017, Volume: 24, Issue:4

    Topics: Analgesics; Anesthetics, Local; Anti-Anxiety Agents; Antitussive Agents; Anxiety; Bronchoscopy; Coug

2017
Intubation conditions in young infants after propofol and remifentanil induction with and without low-dose rocuronium.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:7

    Topics: Androstanols; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Cough;

2014
Spray-as-you-go airway topical anesthesia in patients with a difficult airway: a randomized, double-blind comparison of 2% and 4% lidocaine.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:2

    Topics: Adult; Aerosols; Anesthesia, Inhalation; Anesthetics, Local; Blood Pressure; Cough; Double-Blind Met

2009
The safety and efficacy of using a concentrated intranasal midazolam formulation for paediatric dental sedation.
    SAAD digest, 2011, Volume: 27

    Topics: Administration, Intranasal; Adolescent; Anesthesia, Dental; Anesthetics, Local; Child; Child Behavio

2011
Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough.
    Irish journal of medical science, 2012, Volume: 181, Issue:4

    Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Cough; Dexmedetomidine; Drug Combinations; Female

2012
Propofol - not thiopental or etomidate - with remifentanil provides adequate intubating conditions in the absence of neuromuscular blockade.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:2

    Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Intravenous; Blood Pressure; Cough; Double-Blind

2003
Propofol and remifentanil for intubation without muscle relaxant: the effect of the order of injection.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:1

    Topics: Adolescent; Adult; Anesthetics, Intravenous; Blood Pressure; Cough; Female; Heart Rate; Humans; Hypn

2004
Cough suppression during flexible bronchoscopy using combined sedation with midazolam and hydrocodone: a randomised, double blind, placebo controlled trial.
    Thorax, 2004, Volume: 59, Issue:9

    Topics: Antitussive Agents; Bronchoalveolar Lavage Fluid; Bronchoscopy; Cough; Double-Blind Method; Drug The

2004
Pre-medication for bronchoscopy: a randomised double blind trial comparing alfentanil with midazolam.
    Respiratory medicine, 2004, Volume: 98, Issue:11

    Topics: Alfentanil; Analgesics, Opioid; Anti-Anxiety Agents; Bronchoscopy; Cough; Double-Blind Method; Human

2004
Conscious sedation--an artist's science! An Indian experience with midazolam.
    Journal of the Indian Society of Pedodontics and Preventive Dentistry, 2006, Volume: 24, Issue:1

    Topics: Administration, Intranasal; Anesthesia Recovery Period; Anesthesia, Dental; Body Weight; Child Behav

2006
Sedation for fibre optic bronchoscopy.
    Respiratory medicine, 1995, Volume: 89, Issue:1

    Topics: Alfentanil; Bronchoscopy; Conscious Sedation; Cough; Double-Blind Method; Drug Therapy, Combination;

1995
Comparison of propofol versus thiopentone with midazolam or lidocaine to facilitate laryngeal mask insertion.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:6

    Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Cough; Drug Costs; Elective Surgical Procedures

1996
[Bronchial endoscopy under local anesthesia and pain in children. The value of a nitrous oxide-oxygen combination].
    Revue des maladies respiratoires, 1998, Volume: 15, Issue:2

    Topics: Adjuvants, Anesthesia; Administration, Rectal; Anesthesia, Local; Anesthetics, Inhalation; Anestheti

1998
Single vital capacity inhalational anaesthetic induction in adults--isoflurane vs sevoflurane.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:10

    Topics: Adolescent; Adult; Anesthesia, Closed-Circuit; Anesthesia, Inhalation; Anesthetics, Inhalation; Coug

1998
Rapid-sequence orotracheal intubation: a comparison of three techniques.
    Anesthesiology, 1990, Volume: 73, Issue:2

    Topics: Abdomen; Adolescent; Adult; Aged; Cough; Electric Stimulation; Humans; Intubation, Intratracheal; Mi

1990
Tussive effect of a fentanyl bolus.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1991, Volume: 38, Issue:3

    Topics: Adult; Analysis of Variance; Anesthesia, Intravenous; Atropine; Blood Pressure; Cough; Double-Blind

1991
[Premedication in fiber optic bronchoscopy from the patient's and the physician's viewpoint--a randomized study for the comparison of midazolam and hydrocodone].
    Schweizerische medizinische Wochenschrift, 1986, Sep-13, Volume: 116, Issue:37

    Topics: Adult; Aged; Bronchoscopy; Codeine; Consumer Behavior; Cough; Dyspnea; Female; Fiber Optic Technolog

1986

Other Studies

8 other studies available for midazolam and Cough

ArticleYear
Cough reflex under intravenous sedation during dental implant surgery is more frequent during procedures in the maxillary anterior region.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2013, Volume: 71, Issue:4

    Topics: Aged; Anesthesia, Dental; Anesthesia, Intravenous; Chi-Square Distribution; Conscious Sedation; Coug

2013
Effect of intravenous dexmedetomidine-midazolam on fentanyl-induced cough.
    Irish journal of medical science, 2014, Volume: 183, Issue:3

    Topics: Anesthetics, Intravenous; Cough; Dexmedetomidine; Female; Humans; Male; Midazolam; Preanesthetic Med

2014
Fentanyl-induced cough during general anesthesia: a different perspective.
    Irish journal of medical science, 2013, Volume: 182, Issue:2

    Topics: Anesthetics, Intravenous; Cough; Dexmedetomidine; Female; Humans; Male; Midazolam; Preanesthetic Med

2013
Quantitative assessment of tracheal collapsibility in infants with tracheomalacia.
    American journal of respiratory and critical care medicine, 2004, Oct-01, Volume: 170, Issue:7

    Topics: Airway Resistance; Anesthesia, General; Body Weight; Bronchoscopy; Case-Control Studies; Compliance;

2004
Pulmonary atelectasis manifested after induction of anesthesia: a contribution of sinobronchial syndrome?
    Journal of anesthesia, 2007, Volume: 21, Issue:1

    Topics: Adult; Airway Obstruction; Analgesics, Opioid; Anesthesia, General; Anesthetics, Intravenous; Blood

2007
Innovative uses of dexmedetomidine.
    Journal of clinical anesthesia, 2007, Volume: 19, Issue:8

    Topics: Analgesics, Non-Narcotic; Anesthetics, Intravenous; Cough; Dexmedetomidine; Fiber Optic Technology;

2007
A survey of pentobarbital sedation for children undergoing abdominal CT scans after oral contrast medium.
    Paediatric anaesthesia, 1997, Volume: 7, Issue:4

    Topics: Adjuvants, Anesthesia; Administration, Oral; Airway Obstruction; Anesthesiology; Bronchial Spasm; Ch

1997
Air embolism during tunneled central catheter placement performed without general anesthesia in children: a potentially serious complication.
    Journal of vascular and interventional radiology : JVIR, 1999, Volume: 10, Issue:6

    Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Catheterization, Central Venous; Catheters, Ind

1999