Page last updated: 2024-10-31

midazolam and Autism

midazolam has been researched along with Autism in 7 studies

Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.

Research Excerpts

ExcerptRelevanceReference
"Children with autism often need sedation for diagnostic procedures and they are often difficult to sedate."6.90A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism. ( Huang, JX; Li, BL; Miller, JW; Song, XR; Yang, SY; Yuen, VM; Zhang, HH; Zhang, N, 2019)
"All had developmental delay (66."5.62The Use of Oral Midazolam to Facilitate the Ophthalmic Examination of Children with Autism and Developmental Disorders. ( Comer, G; Flanagan, O; McBride, GR; Stephenson, KAJ, 2021)
"Records of children with autism or neurobehavioral disorders sedated with dexmedetomidine at Chris Evert Children's Hospital and Kosair Children's Hospital were reviewed."5.35Dexmedetomidine for procedural sedation in children with autism and other behavior disorders. ( Berkenbosch, JW; Lubisch, N; Roskos, R, 2009)
"Forty consecutive patients with neurological disorders (encephalopathy, autism, and epilepsy) were referred to dental treatment, and 45 sedations were performed; all were sedated with Midazolam (intramuscular 0."3.76Special care dentistry: Midazolam conscious sedation for patients with neurological diseases. ( Capp, PL; Cillo, MT; de Faria, ME; de Siqueira, JT; Prado, EG; Siqueira, SR, 2010)
"Children with autism often need sedation for diagnostic procedures and they are often difficult to sedate."2.90A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism. ( Huang, JX; Li, BL; Miller, JW; Song, XR; Yang, SY; Yuen, VM; Zhang, HH; Zhang, N, 2019)
"All had developmental delay (66."1.62The Use of Oral Midazolam to Facilitate the Ophthalmic Examination of Children with Autism and Developmental Disorders. ( Comer, G; Flanagan, O; McBride, GR; Stephenson, KAJ, 2021)
"Records of children with autism or neurobehavioral disorders sedated with dexmedetomidine at Chris Evert Children's Hospital and Kosair Children's Hospital were reviewed."1.35Dexmedetomidine for procedural sedation in children with autism and other behavior disorders. ( Berkenbosch, JW; Lubisch, N; Roskos, R, 2009)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
McBride, GR1
Stephenson, KAJ1
Comer, G1
Flanagan, O1
Stuker, EW1
Eskander, JP1
Gennuso, SA1
Li, BL1
Yuen, VM1
Zhang, N1
Zhang, HH1
Huang, JX1
Yang, SY1
Miller, JW1
Song, XR1
Shah, S2
Apuya, J1
Gopalakrishnan, S1
Martin, T1
Lubisch, N1
Roskos, R1
Berkenbosch, JW1
Capp, PL1
de Faria, ME1
Siqueira, SR1
Cillo, MT1
Prado, EG1
de Siqueira, JT1
Fukuta, O1
Braham, RL1
Yanase, H1
Atsumi, N1
Kurosu, K1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Sedation to Electroencephalography With Dexmedetomidine or Chloral Hydrate: a Comparative Study of the Qualitative and Quantitative Electroencephalogram Pattern[NCT01083797]Phase 325 participants (Actual)Interventional2009-12-31Completed
The Use of Dexmedetomidine for Procedural Sedation During EEG in Children Affected by Behavioural Disorders[NCT03799783]Phase 219 participants (Actual)Interventional2018-03-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Patients That Reach a Score Equal or Lower Than 2 Ten Minutes After the Infusion of Dexmedetomidine (Assessed With the PSSS Pediatric Sedation State Scale)

the PSSS is a validated scale for assessing the level of procedural sedation. It is a 6 items scale , from 0 to 5, where 5 is an alert patient and 0 is a deep sedation with abnormal vital signs. We evaluate patients 10 minutes after the infusion of dexmedetomidine. (NCT03799783)
Timeframe: 10 minutes

InterventionParticipants (Count of Participants)
Dexmedetomidine13

Number of Patients With Adverse Events

any adverse event potentially related with DEX-administration (NCT03799783)
Timeframe: during and immediately after DEX infusion, up to 150 minutes after DEX infusion (time to first awakening)

InterventionParticipants (Count of Participants)
Dexmedetomidine10

Trials

1 trial available for midazolam and Autism

ArticleYear
A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism.
    Journal of autism and developmental disorders, 2019, Volume: 49, Issue:9

    Topics: Administration, Buccal; Administration, Intranasal; Autistic Disorder; Child; Child, Preschool; Dexm

2019

Other Studies

6 other studies available for midazolam and Autism

ArticleYear
The Use of Oral Midazolam to Facilitate the Ophthalmic Examination of Children with Autism and Developmental Disorders.
    Journal of autism and developmental disorders, 2021, Volume: 51, Issue:5

    Topics: Administration, Oral; Autistic Disorder; Child; Child, Preschool; Cohort Studies; Conscious Sedation

2021
Third time's a charm: Oral midazolam vs intranasal dexmedetomidine for preoperative anxiolysis in an autistic pediatric patient.
    Paediatric anaesthesia, 2018, Volume: 28, Issue:4

    Topics: Administration, Intranasal; Autistic Disorder; Child; Conscious Sedation; Dental Restoration, Perman

2018
Combination of oral ketamine and midazolam as a premedication for a severely autistic and combative patient.
    Journal of anesthesia, 2009, Volume: 23, Issue:1

    Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Autistic Disorder; Beverages; Humans; Hypnoti

2009
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
    Pediatric neurology, 2009, Volume: 41, Issue:2

    Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi

2009
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
    Pediatric neurology, 2009, Volume: 41, Issue:2

    Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi

2009
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
    Pediatric neurology, 2009, Volume: 41, Issue:2

    Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi

2009
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
    Pediatric neurology, 2009, Volume: 41, Issue:2

    Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi

2009
Special care dentistry: Midazolam conscious sedation for patients with neurological diseases.
    European journal of paediatric dentistry, 2010, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Anesthesia, Dental; Anesthetics, Local; Autistic Disorder; Brain Damage, Chronic;

2010
The sedative effect of intranasal midazolam administration in the dental treatment of patients with mental disabilities. Part 1. The effect of a 0.2 mg/kg dose.
    The Journal of clinical pediatric dentistry, 1993,Summer, Volume: 17, Issue:4

    Topics: Administration, Intranasal; Adolescent; Adult; Analysis of Variance; Anesthesia, Dental; Autistic Di

1993