midazolam and Autism
midazolam has been researched along with Autism in 7 studies
Midazolam: A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
midazolam : An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Children with autism often need sedation for diagnostic procedures and they are often difficult to sedate." | 6.90 | A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism. ( Huang, JX; Li, BL; Miller, JW; Song, XR; Yang, SY; Yuen, VM; Zhang, HH; Zhang, N, 2019) |
| "All had developmental delay (66." | 5.62 | The Use of Oral Midazolam to Facilitate the Ophthalmic Examination of Children with Autism and Developmental Disorders. ( Comer, G; Flanagan, O; McBride, GR; Stephenson, KAJ, 2021) |
| "Records of children with autism or neurobehavioral disorders sedated with dexmedetomidine at Chris Evert Children's Hospital and Kosair Children's Hospital were reviewed." | 5.35 | Dexmedetomidine for procedural sedation in children with autism and other behavior disorders. ( Berkenbosch, JW; Lubisch, N; Roskos, R, 2009) |
| "Forty consecutive patients with neurological disorders (encephalopathy, autism, and epilepsy) were referred to dental treatment, and 45 sedations were performed; all were sedated with Midazolam (intramuscular 0." | 3.76 | Special care dentistry: Midazolam conscious sedation for patients with neurological diseases. ( Capp, PL; Cillo, MT; de Faria, ME; de Siqueira, JT; Prado, EG; Siqueira, SR, 2010) |
| "Children with autism often need sedation for diagnostic procedures and they are often difficult to sedate." | 2.90 | A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism. ( Huang, JX; Li, BL; Miller, JW; Song, XR; Yang, SY; Yuen, VM; Zhang, HH; Zhang, N, 2019) |
| "All had developmental delay (66." | 1.62 | The Use of Oral Midazolam to Facilitate the Ophthalmic Examination of Children with Autism and Developmental Disorders. ( Comer, G; Flanagan, O; McBride, GR; Stephenson, KAJ, 2021) |
| "Records of children with autism or neurobehavioral disorders sedated with dexmedetomidine at Chris Evert Children's Hospital and Kosair Children's Hospital were reviewed." | 1.35 | Dexmedetomidine for procedural sedation in children with autism and other behavior disorders. ( Berkenbosch, JW; Lubisch, N; Roskos, R, 2009) |
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| McBride, GR | 1 |
| Stephenson, KAJ | 1 |
| Comer, G | 1 |
| Flanagan, O | 1 |
| Stuker, EW | 1 |
| Eskander, JP | 1 |
| Gennuso, SA | 1 |
| Li, BL | 1 |
| Yuen, VM | 1 |
| Zhang, N | 1 |
| Zhang, HH | 1 |
| Huang, JX | 1 |
| Yang, SY | 1 |
| Miller, JW | 1 |
| Song, XR | 1 |
| Shah, S | 2 |
| Apuya, J | 1 |
| Gopalakrishnan, S | 1 |
| Martin, T | 1 |
| Lubisch, N | 1 |
| Roskos, R | 1 |
| Berkenbosch, JW | 1 |
| Capp, PL | 1 |
| de Faria, ME | 1 |
| Siqueira, SR | 1 |
| Cillo, MT | 1 |
| Prado, EG | 1 |
| de Siqueira, JT | 1 |
| Fukuta, O | 1 |
| Braham, RL | 1 |
| Yanase, H | 1 |
| Atsumi, N | 1 |
| Kurosu, K | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sedation to Electroencephalography With Dexmedetomidine or Chloral Hydrate: a Comparative Study of the Qualitative and Quantitative Electroencephalogram Pattern[NCT01083797] | Phase 3 | 25 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| The Use of Dexmedetomidine for Procedural Sedation During EEG in Children Affected by Behavioural Disorders[NCT03799783] | Phase 2 | 19 participants (Actual) | Interventional | 2018-03-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Number of Patients That Reach a Score Equal or Lower Than 2 Ten Minutes After the Infusion of Dexmedetomidine (Assessed With the PSSS Pediatric Sedation State Scale)
the PSSS is a validated scale for assessing the level of procedural sedation. It is a 6 items scale , from 0 to 5, where 5 is an alert patient and 0 is a deep sedation with abnormal vital signs. We evaluate patients 10 minutes after the infusion of dexmedetomidine. (NCT03799783)
Timeframe: 10 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Dexmedetomidine | 13 |
Number of Patients With Adverse Events
any adverse event potentially related with DEX-administration (NCT03799783)
Timeframe: during and immediately after DEX infusion, up to 150 minutes after DEX infusion (time to first awakening)
| Intervention | Participants (Count of Participants) |
|---|---|
| Dexmedetomidine | 10 |
Trials
1 trial available for midazolam and Autism
| Article | Year |
|---|---|
A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism.
Topics: Administration, Buccal; Administration, Intranasal; Autistic Disorder; Child; Child, Preschool; Dexm | 2019 |
Other Studies
6 other studies available for midazolam and Autism
| Article | Year |
|---|---|
The Use of Oral Midazolam to Facilitate the Ophthalmic Examination of Children with Autism and Developmental Disorders.
Topics: Administration, Oral; Autistic Disorder; Child; Child, Preschool; Cohort Studies; Conscious Sedation | 2021 |
Third time's a charm: Oral midazolam vs intranasal dexmedetomidine for preoperative anxiolysis in an autistic pediatric patient.
Topics: Administration, Intranasal; Autistic Disorder; Child; Conscious Sedation; Dental Restoration, Perman | 2018 |
Combination of oral ketamine and midazolam as a premedication for a severely autistic and combative patient.
Topics: Adult; Anesthesia, General; Anesthetics, Dissociative; Autistic Disorder; Beverages; Humans; Hypnoti | 2009 |
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi | 2009 |
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi | 2009 |
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi | 2009 |
Dexmedetomidine for procedural sedation in children with autism and other behavior disorders.
Topics: Adolescent; Age Factors; Autistic Disorder; Child; Child, Preschool; Conscious Sedation; Dexmedetomi | 2009 |
Special care dentistry: Midazolam conscious sedation for patients with neurological diseases.
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthetics, Local; Autistic Disorder; Brain Damage, Chronic; | 2010 |
The sedative effect of intranasal midazolam administration in the dental treatment of patients with mental disabilities. Part 1. The effect of a 0.2 mg/kg dose.
Topics: Administration, Intranasal; Adolescent; Adult; Analysis of Variance; Anesthesia, Dental; Autistic Di | 1993 |