Page last updated: 2024-10-31

methiothepin and Ache

methiothepin has been researched along with Ache in 4 studies

Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).

Research Excerpts

ExcerptRelevanceReference
"The role of oxytocin (OXT) in pain modulation has been suggested."3.83The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception. ( Condés-Lara, M; Godínez-Chaparro, B; González-Hernández, A; Manzano-García, A; Martínez-Lorenzana, G; Rodríguez-Jiménez, J; Rojas-Piloni, G, 2016)
"Paw skin incision is a well-established postoperative pain model that causes behavioral nociceptive responses and enhanced excitability of spinal dorsal horn neurons."1.36Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats. ( Del Bel, EA; Dias, QM; Prado, WA; Silveira, JW, 2010)
" After chronic administration (2 or 5 mg/kg for 18 consecutive days) tolerance to the effect of metitepin (0."1.27Mechanisms by which the putative serotonin receptor antagonist metitepin alters nociception in mice. ( Berge, OG; Eide, PK; Hole, K, 1988)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Godínez-Chaparro, B1
Martínez-Lorenzana, G1
Rodríguez-Jiménez, J1
Manzano-García, A1
Rojas-Piloni, G1
Condés-Lara, M1
González-Hernández, A1
Silveira, JW1
Dias, QM1
Del Bel, EA1
Prado, WA1
Lozano-Cuenca, J1
Castañeda-Hernández, G1
Granados-Soto, V1
Eide, PK1
Hole, K1
Berge, OG1

Other Studies

4 other studies available for methiothepin and Ache

ArticleYear
The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception.
    Neuropeptides, 2016, Volume: 60

    Topics: Animals; Electric Stimulation; Formaldehyde; Hyperalgesia; Male; Methiothepin; Nociception; Oxytocin

2016
Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats.
    Molecular pain, 2010, Mar-23, Volume: 6

    Topics: Animals; Atropine; Cholinergic Antagonists; Immunohistochemistry; Ketanserin; Male; Methiothepin; Me

2010
Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib.
    European journal of pharmacology, 2005, Apr-18, Volume: 513, Issue:1-2

    Topics: Analgesics; Animals; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship

2005
Mechanisms by which the putative serotonin receptor antagonist metitepin alters nociception in mice.
    Journal of neural transmission, 1988, Volume: 73, Issue:1

    Topics: 5,7-Dihydroxytryptamine; Animals; Dibenzothiepins; Dihydroxytryptamines; Fenclonine; Male; Methiothe

1988