methiothepin has been researched along with Ache in 4 studies
Methiothepin: A serotonin receptor antagonist in the CENTRAL NERVOUS SYSTEM used as an antipsychotic.
methiothepin : A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of oxytocin (OXT) in pain modulation has been suggested." | 3.83 | The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception. ( Condés-Lara, M; Godínez-Chaparro, B; González-Hernández, A; Manzano-García, A; Martínez-Lorenzana, G; Rodríguez-Jiménez, J; Rojas-Piloni, G, 2016) |
| "Paw skin incision is a well-established postoperative pain model that causes behavioral nociceptive responses and enhanced excitability of spinal dorsal horn neurons." | 1.36 | Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats. ( Del Bel, EA; Dias, QM; Prado, WA; Silveira, JW, 2010) |
| " After chronic administration (2 or 5 mg/kg for 18 consecutive days) tolerance to the effect of metitepin (0." | 1.27 | Mechanisms by which the putative serotonin receptor antagonist metitepin alters nociception in mice. ( Berge, OG; Eide, PK; Hole, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Godínez-Chaparro, B | 1 |
| Martínez-Lorenzana, G | 1 |
| Rodríguez-Jiménez, J | 1 |
| Manzano-García, A | 1 |
| Rojas-Piloni, G | 1 |
| Condés-Lara, M | 1 |
| González-Hernández, A | 1 |
| Silveira, JW | 1 |
| Dias, QM | 1 |
| Del Bel, EA | 1 |
| Prado, WA | 1 |
| Lozano-Cuenca, J | 1 |
| Castañeda-Hernández, G | 1 |
| Granados-Soto, V | 1 |
| Eide, PK | 1 |
| Hole, K | 1 |
| Berge, OG | 1 |
4 other studies available for methiothepin and Ache
| Article | Year |
|---|---|
The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception.
Topics: Animals; Electric Stimulation; Formaldehyde; Hyperalgesia; Male; Methiothepin; Nociception; Oxytocin | 2016 |
Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats.
Topics: Animals; Atropine; Cholinergic Antagonists; Immunohistochemistry; Ketanserin; Male; Methiothepin; Me | 2010 |
Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib.
Topics: Analgesics; Animals; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship | 2005 |
Mechanisms by which the putative serotonin receptor antagonist metitepin alters nociception in mice.
Topics: 5,7-Dihydroxytryptamine; Animals; Dibenzothiepins; Dihydroxytryptamines; Fenclonine; Male; Methiothe | 1988 |