Page last updated: 2024-10-19

melatonin and MODS

melatonin has been researched along with MODS in 13 studies

Research Excerpts

ExcerptRelevanceReference
" Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke."7.79Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013)
"Melatonin reportedly exerts beneficial effects to attenuate multiple organ dysfunction syndrome (MODS) in septic shock."7.77Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats. ( Li, YL; Lin, MT; Lin, XJ; Liu, J; Liu, SJ; Mei, GP; Zhao, TB; Zuo, D, 2011)
"Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats."7.73Melatonin protects against oxidative organ injury in a rat model of sepsis. ( Ercan, F; Erkanli, G; Kaçmaz, A; Kapucu, C; Sener, G; Tilki, M; Toklu, H; Yeğen, BC, 2005)
"Melatonin has demonstrated protective effects in severe sepsis/shock in the animal model."7.72The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. ( Blask, D; Dauchy, R; Dietz, PA; Lynch, D; Reynolds, FD; Zuckerman, R, 2003)
"The aim of this study was to investigate the influence of melatonin on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats."7.72Effects of melatonin on acute necrotizing pancreatitis in rats. ( Alhan, E; Erçin, C; Kalyoncu, NI; Kural, BV, 2004)
"We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) in unanesthetized rats."7.70Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. ( Acuña-Castroviejo, D; Crespo, E; Escames, G; Guerrero, JM; Macías, M; Martín, M; Pozo, D; Vives, F, 1999)
"Treatment with melatonin preserved the mean arterial pressure, decreased tachycardia, and markers of organ injury, and suppressed the release of TNF-α and IL-6, with no change in hemoglobulin after HS in rats."5.37Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. ( Hsu, BG; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM; Yang, FL, 2011)
"The pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock is complicated and not fully understood."5.35Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. ( Chen, SJ; Chen, TH; Tsao, CM; Tsou, MY; Wu, CC; Wu, JY, 2008)
" Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke."3.79Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013)
"Melatonin reportedly exerts beneficial effects to attenuate multiple organ dysfunction syndrome (MODS) in septic shock."3.77Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats. ( Li, YL; Lin, MT; Lin, XJ; Liu, J; Liu, SJ; Mei, GP; Zhao, TB; Zuo, D, 2011)
"Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats."3.73Melatonin protects against oxidative organ injury in a rat model of sepsis. ( Ercan, F; Erkanli, G; Kaçmaz, A; Kapucu, C; Sener, G; Tilki, M; Toklu, H; Yeğen, BC, 2005)
"Melatonin has demonstrated protective effects in severe sepsis/shock in the animal model."3.72The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. ( Blask, D; Dauchy, R; Dietz, PA; Lynch, D; Reynolds, FD; Zuckerman, R, 2003)
"The aim of this study was to investigate the influence of melatonin on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats."3.72Effects of melatonin on acute necrotizing pancreatitis in rats. ( Alhan, E; Erçin, C; Kalyoncu, NI; Kural, BV, 2004)
"We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) in unanesthetized rats."3.70Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. ( Acuña-Castroviejo, D; Crespo, E; Escames, G; Guerrero, JM; Macías, M; Martín, M; Pozo, D; Vives, F, 1999)
"Sepsis is one of the main causes of death among critically ill patients."2.55Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy. ( Prauchner, CA, 2017)
"Melatonin plays an important physiologic role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control, and regulation of mood."2.46Melatonin in septic shock: some recent concepts. ( Cardinali, DP; Kato, H; Pandi-Perumal, SR; Spence, DW; Srinivasan, V, 2010)
"Treatment with melatonin preserved the mean arterial pressure, decreased tachycardia, and markers of organ injury, and suppressed the release of TNF-α and IL-6, with no change in hemoglobulin after HS in rats."1.37Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. ( Hsu, BG; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM; Yang, FL, 2011)
"The pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock is complicated and not fully understood."1.35Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. ( Chen, SJ; Chen, TH; Tsao, CM; Tsou, MY; Wu, CC; Wu, JY, 2008)
"Melatonin treatment counteracted these alterations in young and aged septic rats."1.33Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment. ( Acuña-Castroviejo, D; Escames, G; López, LC; Ortiz, F; Ros, E, 2006)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's6 (46.15)29.6817
2010's6 (46.15)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tian, YF1
Lin, CH1
Hsu, SF1
Lin, MT2
Prauchner, CA1
Yang, FL1
Subeq, YM1
Lee, CJ1
Lee, RP1
Peng, TC1
Hsu, BG1
Srinivasan, V1
Pandi-Perumal, SR1
Spence, DW1
Kato, H1
Cardinali, DP1
Lin, XJ1
Mei, GP1
Liu, J1
Li, YL1
Zuo, D1
Liu, SJ1
Zhao, TB1
Lowes, DA1
Webster, NR1
Murphy, MP1
Galley, HF1
Reynolds, FD1
Dauchy, R1
Blask, D1
Dietz, PA1
Lynch, D1
Zuckerman, R1
Alhan, E1
Kalyoncu, NI1
Kural, BV1
Erçin, C1
Sener, G1
Toklu, H1
Kapucu, C1
Ercan, F1
Erkanli, G1
Kaçmaz, A1
Tilki, M1
Yeğen, BC1
Escames, G2
López, LC1
Ortiz, F1
Ros, E1
Acuña-Castroviejo, D2
Wu, JY1
Tsou, MY1
Chen, TH1
Chen, SJ1
Tsao, CM1
Wu, CC1
Crespo, E1
Macías, M1
Pozo, D1
Martín, M1
Vives, F1
Guerrero, JM1
Liaw, SJ1
Chen, JC1
Ng, CJ1
Chiu, DF1
Chen, MF1
Chen, HM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946]Phase 2/Phase 360 participants (Anticipated)Interventional2023-03-10Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for melatonin and MODS

ArticleYear
Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy.
    Burns : journal of the International Society for Burn Injuries, 2017, Volume: 43, Issue:3

    Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Humans; Melatonin; Mitochondria; Multiple

2017
Melatonin in septic shock: some recent concepts.
    Journal of critical care, 2010, Volume: 25, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Humans; Inflammation; Melatoni

2010

Other Studies

11 other studies available for melatonin and MODS

ArticleYear
Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction.
    Mediators of inflammation, 2013, Volume: 2013

    Topics: Adrenocorticotropic Hormone; Animals; Antioxidants; Corticosterone; Disease Models, Animal; Glutathi

2013
Melatonin ameliorates hemorrhagic shock-induced organ damage in rats.
    The Journal of surgical research, 2011, May-15, Volume: 167, Issue:2

    Topics: Animals; Antioxidants; Blood Pressure; Disease Models, Animal; Heart Rate; Interleukin-6; Intestine,

2011
Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats.
    Journal of pineal research, 2011, Volume: 50, Issue:4

    Topics: Animals; Antioxidants; Heat Stroke; Intercellular Adhesion Molecule-1; Interleukin-10; Interleukin-1

2011
Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis.
    British journal of anaesthesia, 2013, Volume: 110, Issue:3

    Topics: Acute Disease; Animals; Antioxidants; Biomarkers; Cytokines; Escherichia coli; Interleukin-6; Kidney

2013
The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A.
    Surgery, 2003, Volume: 134, Issue:3

    Topics: Animals; Disease Models, Animal; Male; Melatonin; Multiple Organ Failure; Rats; Rats, Sprague-Dawley

2003
Effects of melatonin on acute necrotizing pancreatitis in rats.
    Zeitschrift fur Gastroenterologie, 2004, Volume: 42, Issue:9

    Topics: Animals; Antioxidants; Clinical Enzyme Tests; Data Interpretation, Statistical; Disease Models, Anim

2004
Melatonin protects against oxidative organ injury in a rat model of sepsis.
    Surgery today, 2005, Volume: 35, Issue:1

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admini

2005
Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment.
    Experimental gerontology, 2006, Volume: 41, Issue:11

    Topics: Aging; Animals; Antioxidants; Endotoxemia; Enzyme Induction; Injections; Kidney Diseases; Lipid Pero

2006
Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats.
    Journal of pineal research, 2008, Volume: 45, Issue:1

    Topics: Animals; Antioxidants; Cecum; Disease Models, Animal; Ligation; Male; Melatonin; Multiple Organ Fail

2008
Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1999, Volume: 13, Issue:12

    Topics: Animals; Drug Administration Schedule; Endotoxemia; Gene Expression Regulation, Enzymologic; Kidney;

1999
Beneficial role of melatonin on microcirculation in endotoxin-induced gastropathy in rats: possible implication in nitrogen oxide reduction.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2002, Volume: 101, Issue:2

    Topics: Animals; Free Radical Scavengers; Gastric Mucosa; Lipopolysaccharides; Male; Melatonin; Microcircula

2002