melatonin has been researched along with MODS in 13 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke." | 7.79 | Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013) |
| "Melatonin reportedly exerts beneficial effects to attenuate multiple organ dysfunction syndrome (MODS) in septic shock." | 7.77 | Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats. ( Li, YL; Lin, MT; Lin, XJ; Liu, J; Liu, SJ; Mei, GP; Zhao, TB; Zuo, D, 2011) |
| "Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats." | 7.73 | Melatonin protects against oxidative organ injury in a rat model of sepsis. ( Ercan, F; Erkanli, G; Kaçmaz, A; Kapucu, C; Sener, G; Tilki, M; Toklu, H; Yeğen, BC, 2005) |
| "Melatonin has demonstrated protective effects in severe sepsis/shock in the animal model." | 7.72 | The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. ( Blask, D; Dauchy, R; Dietz, PA; Lynch, D; Reynolds, FD; Zuckerman, R, 2003) |
| "The aim of this study was to investigate the influence of melatonin on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats." | 7.72 | Effects of melatonin on acute necrotizing pancreatitis in rats. ( Alhan, E; Erçin, C; Kalyoncu, NI; Kural, BV, 2004) |
| "We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) in unanesthetized rats." | 7.70 | Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. ( Acuña-Castroviejo, D; Crespo, E; Escames, G; Guerrero, JM; Macías, M; Martín, M; Pozo, D; Vives, F, 1999) |
| "Treatment with melatonin preserved the mean arterial pressure, decreased tachycardia, and markers of organ injury, and suppressed the release of TNF-α and IL-6, with no change in hemoglobulin after HS in rats." | 5.37 | Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. ( Hsu, BG; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM; Yang, FL, 2011) |
| "The pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock is complicated and not fully understood." | 5.35 | Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. ( Chen, SJ; Chen, TH; Tsao, CM; Tsou, MY; Wu, CC; Wu, JY, 2008) |
| " Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke." | 3.79 | Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013) |
| "Melatonin reportedly exerts beneficial effects to attenuate multiple organ dysfunction syndrome (MODS) in septic shock." | 3.77 | Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats. ( Li, YL; Lin, MT; Lin, XJ; Liu, J; Liu, SJ; Mei, GP; Zhao, TB; Zuo, D, 2011) |
| "Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats." | 3.73 | Melatonin protects against oxidative organ injury in a rat model of sepsis. ( Ercan, F; Erkanli, G; Kaçmaz, A; Kapucu, C; Sener, G; Tilki, M; Toklu, H; Yeğen, BC, 2005) |
| "Melatonin has demonstrated protective effects in severe sepsis/shock in the animal model." | 3.72 | The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. ( Blask, D; Dauchy, R; Dietz, PA; Lynch, D; Reynolds, FD; Zuckerman, R, 2003) |
| "The aim of this study was to investigate the influence of melatonin on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats." | 3.72 | Effects of melatonin on acute necrotizing pancreatitis in rats. ( Alhan, E; Erçin, C; Kalyoncu, NI; Kural, BV, 2004) |
| "We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) in unanesthetized rats." | 3.70 | Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. ( Acuña-Castroviejo, D; Crespo, E; Escames, G; Guerrero, JM; Macías, M; Martín, M; Pozo, D; Vives, F, 1999) |
| "Sepsis is one of the main causes of death among critically ill patients." | 2.55 | Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy. ( Prauchner, CA, 2017) |
| "Melatonin plays an important physiologic role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control, and regulation of mood." | 2.46 | Melatonin in septic shock: some recent concepts. ( Cardinali, DP; Kato, H; Pandi-Perumal, SR; Spence, DW; Srinivasan, V, 2010) |
| "Treatment with melatonin preserved the mean arterial pressure, decreased tachycardia, and markers of organ injury, and suppressed the release of TNF-α and IL-6, with no change in hemoglobulin after HS in rats." | 1.37 | Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. ( Hsu, BG; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM; Yang, FL, 2011) |
| "The pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock is complicated and not fully understood." | 1.35 | Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. ( Chen, SJ; Chen, TH; Tsao, CM; Tsou, MY; Wu, CC; Wu, JY, 2008) |
| "Melatonin treatment counteracted these alterations in young and aged septic rats." | 1.33 | Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment. ( Acuña-Castroviejo, D; Escames, G; López, LC; Ortiz, F; Ros, E, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tian, YF | 1 |
| Lin, CH | 1 |
| Hsu, SF | 1 |
| Lin, MT | 2 |
| Prauchner, CA | 1 |
| Yang, FL | 1 |
| Subeq, YM | 1 |
| Lee, CJ | 1 |
| Lee, RP | 1 |
| Peng, TC | 1 |
| Hsu, BG | 1 |
| Srinivasan, V | 1 |
| Pandi-Perumal, SR | 1 |
| Spence, DW | 1 |
| Kato, H | 1 |
| Cardinali, DP | 1 |
| Lin, XJ | 1 |
| Mei, GP | 1 |
| Liu, J | 1 |
| Li, YL | 1 |
| Zuo, D | 1 |
| Liu, SJ | 1 |
| Zhao, TB | 1 |
| Lowes, DA | 1 |
| Webster, NR | 1 |
| Murphy, MP | 1 |
| Galley, HF | 1 |
| Reynolds, FD | 1 |
| Dauchy, R | 1 |
| Blask, D | 1 |
| Dietz, PA | 1 |
| Lynch, D | 1 |
| Zuckerman, R | 1 |
| Alhan, E | 1 |
| Kalyoncu, NI | 1 |
| Kural, BV | 1 |
| Erçin, C | 1 |
| Sener, G | 1 |
| Toklu, H | 1 |
| Kapucu, C | 1 |
| Ercan, F | 1 |
| Erkanli, G | 1 |
| Kaçmaz, A | 1 |
| Tilki, M | 1 |
| Yeğen, BC | 1 |
| Escames, G | 2 |
| López, LC | 1 |
| Ortiz, F | 1 |
| Ros, E | 1 |
| Acuña-Castroviejo, D | 2 |
| Wu, JY | 1 |
| Tsou, MY | 1 |
| Chen, TH | 1 |
| Chen, SJ | 1 |
| Tsao, CM | 1 |
| Wu, CC | 1 |
| Crespo, E | 1 |
| Macías, M | 1 |
| Pozo, D | 1 |
| Martín, M | 1 |
| Vives, F | 1 |
| Guerrero, JM | 1 |
| Liaw, SJ | 1 |
| Chen, JC | 1 |
| Ng, CJ | 1 |
| Chiu, DF | 1 |
| Chen, MF | 1 |
| Chen, HM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for melatonin and MODS
| Article | Year |
|---|---|
Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Humans; Melatonin; Mitochondria; Multiple | 2017 |
Melatonin in septic shock: some recent concepts.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Humans; Inflammation; Melatoni | 2010 |
11 other studies available for melatonin and MODS
| Article | Year |
|---|---|
Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction.
Topics: Adrenocorticotropic Hormone; Animals; Antioxidants; Corticosterone; Disease Models, Animal; Glutathi | 2013 |
Melatonin ameliorates hemorrhagic shock-induced organ damage in rats.
Topics: Animals; Antioxidants; Blood Pressure; Disease Models, Animal; Heart Rate; Interleukin-6; Intestine, | 2011 |
Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats.
Topics: Animals; Antioxidants; Heat Stroke; Intercellular Adhesion Molecule-1; Interleukin-10; Interleukin-1 | 2011 |
Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis.
Topics: Acute Disease; Animals; Antioxidants; Biomarkers; Cytokines; Escherichia coli; Interleukin-6; Kidney | 2013 |
The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Multiple Organ Failure; Rats; Rats, Sprague-Dawley | 2003 |
Effects of melatonin on acute necrotizing pancreatitis in rats.
Topics: Animals; Antioxidants; Clinical Enzyme Tests; Data Interpretation, Statistical; Disease Models, Anim | 2004 |
Melatonin protects against oxidative organ injury in a rat model of sepsis.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admini | 2005 |
Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment.
Topics: Aging; Animals; Antioxidants; Endotoxemia; Enzyme Induction; Injections; Kidney Diseases; Lipid Pero | 2006 |
Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats.
Topics: Animals; Antioxidants; Cecum; Disease Models, Animal; Ligation; Male; Melatonin; Multiple Organ Fail | 2008 |
Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats.
Topics: Animals; Drug Administration Schedule; Endotoxemia; Gene Expression Regulation, Enzymologic; Kidney; | 1999 |
Beneficial role of melatonin on microcirculation in endotoxin-induced gastropathy in rats: possible implication in nitrogen oxide reduction.
Topics: Animals; Free Radical Scavengers; Gastric Mucosa; Lipopolysaccharides; Male; Melatonin; Microcircula | 2002 |