melatonin has been researched along with MODS in 13 studies
Excerpt | Relevance | Reference |
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" Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke." | 7.79 | Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013) |
"Melatonin reportedly exerts beneficial effects to attenuate multiple organ dysfunction syndrome (MODS) in septic shock." | 7.77 | Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats. ( Li, YL; Lin, MT; Lin, XJ; Liu, J; Liu, SJ; Mei, GP; Zhao, TB; Zuo, D, 2011) |
"Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats." | 7.73 | Melatonin protects against oxidative organ injury in a rat model of sepsis. ( Ercan, F; Erkanli, G; Kaçmaz, A; Kapucu, C; Sener, G; Tilki, M; Toklu, H; Yeğen, BC, 2005) |
"Melatonin has demonstrated protective effects in severe sepsis/shock in the animal model." | 7.72 | The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. ( Blask, D; Dauchy, R; Dietz, PA; Lynch, D; Reynolds, FD; Zuckerman, R, 2003) |
"The aim of this study was to investigate the influence of melatonin on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats." | 7.72 | Effects of melatonin on acute necrotizing pancreatitis in rats. ( Alhan, E; Erçin, C; Kalyoncu, NI; Kural, BV, 2004) |
"We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) in unanesthetized rats." | 7.70 | Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. ( Acuña-Castroviejo, D; Crespo, E; Escames, G; Guerrero, JM; Macías, M; Martín, M; Pozo, D; Vives, F, 1999) |
"Treatment with melatonin preserved the mean arterial pressure, decreased tachycardia, and markers of organ injury, and suppressed the release of TNF-α and IL-6, with no change in hemoglobulin after HS in rats." | 5.37 | Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. ( Hsu, BG; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM; Yang, FL, 2011) |
"The pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock is complicated and not fully understood." | 5.35 | Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. ( Chen, SJ; Chen, TH; Tsao, CM; Tsou, MY; Wu, CC; Wu, JY, 2008) |
" Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke." | 3.79 | Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction. ( Hsu, SF; Lin, CH; Lin, MT; Tian, YF, 2013) |
"Melatonin reportedly exerts beneficial effects to attenuate multiple organ dysfunction syndrome (MODS) in septic shock." | 3.77 | Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats. ( Li, YL; Lin, MT; Lin, XJ; Liu, J; Liu, SJ; Mei, GP; Zhao, TB; Zuo, D, 2011) |
"Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against sepsis-induced oxidative organ damage in rats." | 3.73 | Melatonin protects against oxidative organ injury in a rat model of sepsis. ( Ercan, F; Erkanli, G; Kaçmaz, A; Kapucu, C; Sener, G; Tilki, M; Toklu, H; Yeğen, BC, 2005) |
"Melatonin has demonstrated protective effects in severe sepsis/shock in the animal model." | 3.72 | The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A. ( Blask, D; Dauchy, R; Dietz, PA; Lynch, D; Reynolds, FD; Zuckerman, R, 2003) |
"The aim of this study was to investigate the influence of melatonin on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats." | 3.72 | Effects of melatonin on acute necrotizing pancreatitis in rats. ( Alhan, E; Erçin, C; Kalyoncu, NI; Kural, BV, 2004) |
"We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) in unanesthetized rats." | 3.70 | Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. ( Acuña-Castroviejo, D; Crespo, E; Escames, G; Guerrero, JM; Macías, M; Martín, M; Pozo, D; Vives, F, 1999) |
"Sepsis is one of the main causes of death among critically ill patients." | 2.55 | Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy. ( Prauchner, CA, 2017) |
"Melatonin plays an important physiologic role in sleep and circadian rhythm regulation, immunoregulation, antioxidant and mitochondrial-protective functions, reproductive control, and regulation of mood." | 2.46 | Melatonin in septic shock: some recent concepts. ( Cardinali, DP; Kato, H; Pandi-Perumal, SR; Spence, DW; Srinivasan, V, 2010) |
"Treatment with melatonin preserved the mean arterial pressure, decreased tachycardia, and markers of organ injury, and suppressed the release of TNF-α and IL-6, with no change in hemoglobulin after HS in rats." | 1.37 | Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. ( Hsu, BG; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM; Yang, FL, 2011) |
"The pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock is complicated and not fully understood." | 1.35 | Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. ( Chen, SJ; Chen, TH; Tsao, CM; Tsou, MY; Wu, CC; Wu, JY, 2008) |
"Melatonin treatment counteracted these alterations in young and aged septic rats." | 1.33 | Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment. ( Acuña-Castroviejo, D; Escames, G; López, LC; Ortiz, F; Ros, E, 2006) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (7.69) | 18.2507 |
2000's | 6 (46.15) | 29.6817 |
2010's | 6 (46.15) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Tian, YF | 1 |
Lin, CH | 1 |
Hsu, SF | 1 |
Lin, MT | 2 |
Prauchner, CA | 1 |
Yang, FL | 1 |
Subeq, YM | 1 |
Lee, CJ | 1 |
Lee, RP | 1 |
Peng, TC | 1 |
Hsu, BG | 1 |
Srinivasan, V | 1 |
Pandi-Perumal, SR | 1 |
Spence, DW | 1 |
Kato, H | 1 |
Cardinali, DP | 1 |
Lin, XJ | 1 |
Mei, GP | 1 |
Liu, J | 1 |
Li, YL | 1 |
Zuo, D | 1 |
Liu, SJ | 1 |
Zhao, TB | 1 |
Lowes, DA | 1 |
Webster, NR | 1 |
Murphy, MP | 1 |
Galley, HF | 1 |
Reynolds, FD | 1 |
Dauchy, R | 1 |
Blask, D | 1 |
Dietz, PA | 1 |
Lynch, D | 1 |
Zuckerman, R | 1 |
Alhan, E | 1 |
Kalyoncu, NI | 1 |
Kural, BV | 1 |
Erçin, C | 1 |
Sener, G | 1 |
Toklu, H | 1 |
Kapucu, C | 1 |
Ercan, F | 1 |
Erkanli, G | 1 |
Kaçmaz, A | 1 |
Tilki, M | 1 |
Yeğen, BC | 1 |
Escames, G | 2 |
López, LC | 1 |
Ortiz, F | 1 |
Ros, E | 1 |
Acuña-Castroviejo, D | 2 |
Wu, JY | 1 |
Tsou, MY | 1 |
Chen, TH | 1 |
Chen, SJ | 1 |
Tsao, CM | 1 |
Wu, CC | 1 |
Crespo, E | 1 |
Macías, M | 1 |
Pozo, D | 1 |
Martín, M | 1 |
Vives, F | 1 |
Guerrero, JM | 1 |
Liaw, SJ | 1 |
Chen, JC | 1 |
Ng, CJ | 1 |
Chiu, DF | 1 |
Chen, MF | 1 |
Chen, HM | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
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The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
2 reviews available for melatonin and MODS
Article | Year |
---|---|
Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Humans; Melatonin; Mitochondria; Multiple | 2017 |
Melatonin in septic shock: some recent concepts.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Humans; Inflammation; Melatoni | 2010 |
11 other studies available for melatonin and MODS
Article | Year |
---|---|
Melatonin improves outcomes of heatstroke in mice by reducing brain inflammation and oxidative damage and multiple organ dysfunction.
Topics: Adrenocorticotropic Hormone; Animals; Antioxidants; Corticosterone; Disease Models, Animal; Glutathi | 2013 |
Melatonin ameliorates hemorrhagic shock-induced organ damage in rats.
Topics: Animals; Antioxidants; Blood Pressure; Disease Models, Animal; Heart Rate; Interleukin-6; Intestine, | 2011 |
Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats.
Topics: Animals; Antioxidants; Heat Stroke; Intercellular Adhesion Molecule-1; Interleukin-10; Interleukin-1 | 2011 |
Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis.
Topics: Acute Disease; Animals; Antioxidants; Biomarkers; Cytokines; Escherichia coli; Interleukin-6; Kidney | 2013 |
The pineal gland hormone melatonin improves survival in a rat model of sepsis/shock induced by zymosan A.
Topics: Animals; Disease Models, Animal; Male; Melatonin; Multiple Organ Failure; Rats; Rats, Sprague-Dawley | 2003 |
Effects of melatonin on acute necrotizing pancreatitis in rats.
Topics: Animals; Antioxidants; Clinical Enzyme Tests; Data Interpretation, Statistical; Disease Models, Anim | 2004 |
Melatonin protects against oxidative organ injury in a rat model of sepsis.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admini | 2005 |
Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment.
Topics: Aging; Animals; Antioxidants; Endotoxemia; Enzyme Induction; Injections; Kidney Diseases; Lipid Pero | 2006 |
Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats.
Topics: Animals; Antioxidants; Cecum; Disease Models, Animal; Ligation; Male; Melatonin; Multiple Organ Fail | 2008 |
Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats.
Topics: Animals; Drug Administration Schedule; Endotoxemia; Gene Expression Regulation, Enzymologic; Kidney; | 1999 |
Beneficial role of melatonin on microcirculation in endotoxin-induced gastropathy in rats: possible implication in nitrogen oxide reduction.
Topics: Animals; Free Radical Scavengers; Gastric Mucosa; Lipopolysaccharides; Male; Melatonin; Microcircula | 2002 |