melatonin has been researched along with Hypoxia in 95 studies
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These studies demonstrate a significant neuroprotective efficacy of melatonin in term neonatal models of hypoxia-ischaemia, and suggest melatonin is a strong candidate for translation to clinical trials in babies with moderate-severe NE." | 9.22 | Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia. ( Golay, X; Han, HJ; Meehan, C; Miller, SL; Pang, R; Robertson, NJ, 2022) |
| "Melatonin confers protection against myocardial injury by reducing inflammation and inhibiting apoptosis." | 8.31 | Melatonin attenuates inflammation and cardiac dysfunction in myocardial infarction by regulating the miRNA-200b-3p/high mobility group box chromosomal protein 1 axis. ( Huo, JL; Liu, ZH; Ren, K; Wu, F, 2023) |
| "Adopting an integrative approach, by combining studies of cardiovascular function with those at cellular and molecular levels, this study investigated whether maternal treatment with melatonin protects against programmed cardiovascular dysfunction in the offspring using an established rodent model of hypoxic pregnancy." | 8.12 | Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy. ( Blanco, CE; Camm, EJ; Galli, GLJ; Giussani, DA; Hansell, JA; Herrera, EA; Lock, MC; Patey, OV; Richter, HG; Trafford, AW; Villamor, E, 2022) |
| "This study aims to investigate the correlation between melatonin and hypoxia induction in cardiomyocytes differentiation." | 8.02 | Melatonin mitigates the adverse effect of hypoxia during myocardial differentiation in mouse embryonic stem cells. ( Jeong, S; Jeung, EB; Lee, B; Lee, JH; Tran, DN; Yoo, YM, 2021) |
| "A high-fat diet (FD)-induced obesity mouse model was subjected to intermittent hypoxia/normoxia events for approximately 8 h per day using an autophagy agonist, rapamycin, or an inhibitor, 3-methyladenine (3-MA), and SRT1720, a sirtuin 1 (SIRT1) activator, or sirtinol, a SIRT1 inhibitor, with or without melatonin for a total of six successive weeks, followed by assessment of expression of autophagy-related genes and activity of serum aminotransferase as well as histological evaluation of tissue morphology." | 7.91 | Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice. ( Han, Y; Jin, M; Li, GC; Liu, HG; Luo, M; Ren, J; You, ZX, 2019) |
| "This study suggests that melatonin may have potential value in the prevention and treatment of various retinal diseases associated with increase of VEGF, vascular leakage and angiogenesis." | 7.85 | Hypoxia-induced vascular endothelial growth factor secretion by retinal pigment epithelial cells is inhibited by melatonin via decreased accumulation of hypoxia-inducible factors-1α protein. ( Chuang, LY; Hu, DN; Lai, YH; Rosen, R; Sassoon, J; Wu, KY; Wu, WC, 2017) |
| "The present results suggest that melatonin prevents the well-recognized increase in glucose levels that usually follows exposure to intermittent hypoxia." | 7.81 | Melatonin prevents hyperglycemia in a model of sleep apnea. ( Fagundes, M; Fiori, CZ; Kaminski, RS; Marroni, NP; Martinez, D; Martins, EF; Montanari, CC; Rosa, DP, 2015) |
| "Experimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction." | 7.81 | Melatonin modulates the fetal cardiovascular defense response to acute hypoxia. ( Allison, BJ; Botting, KJ; Giussani, DA; Herrera, EA; Niu, Y; Serón-Ferré, M; Thakor, AS, 2015) |
| " We tested the hypothesis that melatonin ameliorates the CIH-induced lipid peroxidation, local inflammation and cellular injury in rat adrenal medulla." | 7.80 | Melatonin attenuates intermittent hypoxia-induced lipid peroxidation and local inflammation in rat adrenal medulla. ( Fung, ML; Liu, Y; Tipoe, GL, 2014) |
| "In cytosol from liver of pacu, Piaractus mesopotamicus, a hypoxia-tolerant fish that dwells in Pantanal, we found an enzyme activity capable of modulating the alkenal 4-hydroxy-2-nonenal (HNE) by conjugating it with glutathione (GST-HNE activity)." | 7.79 | Melatonin affects conjugation of 4-hydroxynonenal with glutathione in liver of pacu, a hypoxia-tolerant fish. ( Bastos, FF; Bastos, JC; Bastos, VL; Dantas, RF; Nogueira, NP; Paes, MC; Righi, BD; Silva, ES; Tobar, SA, 2013) |
| "To investigate the neuroprotective effect of melatonin against chronic intermittent hypoxia (CIH), the major pathophysiologic features of obstructive sleep apnea syndrome." | 7.79 | Melatonin attenuates hippocampal neuron apoptosis and oxidative stress during chronic intermittent hypoxia via up-regulating B-cell lymphoma-2 and down-regulating B-cell lymphoma-2-associated X protein. ( Guo, X; Liu, H; Tan, X, 2013) |
| "The effects of melatonin and epithalamin on the content of protein and lipid peroxidation products in the cortex and hippocampus of hypoxic rats were studied under conditions of acute hypobaric hypoxia equivalent to the altitude of 12,000 m." | 7.78 | Effects of melatonin and epithalamin on the content of protein and lipid peroxidation products in rat cortex and hippocampus under conditions of acute hypoxia. ( Khavinson, VKh; Sopova, IY; Zamorskii, II, 2012) |
| "We designed the present study to evaluate the efficacy of melatonin (M) on the severity of necrotizing enterocolitis (NEC) in a neonatal rat model." | 7.77 | Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model. ( Gundogdu, G; Guven, A; Korkmaz, A; Oztas, E; Ozturk, H; Uysal, B, 2011) |
| "Melatonin protects against hippocampal injury induced by intermittent hypoxia (IH)." | 7.74 | Melatonin ameliorates hippocampal nitric oxide production and large conductance calcium-activated potassium channel activity in chronic intermittent hypoxia. ( Fung, ML; Hung, MW; Li, MF; Tjong, YW, 2008) |
| " We tested the sensitivity of PT to preconditioning with hypobaric hypoxia and to pretreatment with melatonin." | 7.74 | Influence of melatonin pretreatment and preconditioning by hypobaric hypoxia on the development of cortical photothrombotic ischemic lesion. ( Bernášková, K; Krýsl, D; Mares, J; Matějovská, I, 2008) |
| " Thus, the present study was designed to determine the effects of hypoxia and reoxygenation on the levels of lipid peroxidation and the morphological changes in the liver of male mice as well as the protective role of melatonin as an antioxidant." | 7.73 | Role of melatonin in reducing hypoxia-induced oxidative stress and morphological changes in the liver of male mice. ( El-Sokkary, GH; Khidr, BM; Younes, HA, 2006) |
| "We studied the effect of melatonin on the relationship between LPO intensity and proteolytic activity in basal nuclei (caudate nucleus, globus pallidus, amygdaloid complex, and nucleus accumbens septi) of rat brain during acute hypobaric hypoxia." | 7.73 | Effect of melatonin on the relationship between lipid peroxidation and proteolytic activity in basal nuclei of rat brain during acute hypoxia. ( Sopova, IY; Zamorskii, II, 2006) |
| " Chronic hypoxia was induced pharmacologically by the administration of the anticonvulsant phenytoin (PHT) during the entire period of pregnancy." | 7.72 | Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. ( Brucknerová, I; Dubovický, M; Juránek, I; Mach, M; Navarová, J; Soltés, L; Ujházy, E; Zeman, M, 2004) |
| "Single intraperitoneal injection of melatonin in a dose of 1 mg/kg prevented accumulation of cGMP and intensification of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypobaric hypoxia (12,000 m)." | 7.70 | Effect of melatonin on cyclic nucleotide content and intensity of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypoxia. ( Pishak, VP; Zamorskii, II, 2000) |
| "Hypoxia has an important role in tumor progression via the up-regulation of growth factors and cellular adaptation genes." | 6.72 | Melatonin as a Therapeutic Agent for the Inhibition of Hypoxia-Induced Tumor Progression: A Description of Possible Mechanisms Involved. ( Akbarzadeh, M; Bastani, S; Farzane, A; Fattahi, A; Mollapour Sisakht, M; Nouri, M; Rastgar Rezaei, Y; Reiter, RJ, 2021) |
| "Melatonin has received attention as a potential antifibrotic agent due to its anti-proliferative actions on PSCs." | 5.72 | Melatonin modulates metabolic adaptation of pancreatic stellate cells subjected to hypoxia. ( Estaras, M; Garcia, A; Gonzalez, A; Iovanna, JL; Martinez, R; Ortiz-Placin, C; Santofimia-Castaño, P, 2022) |
| "The hypoxic microenvironment of cryptorchidism is an important factor in the impairment and fibrosis of Sertoli cells which result in blood-testis barrier (BTB) destruction and spermatogenesis loss." | 5.72 | Melatonin through blockade of Hif-1α signaling mediates the anti-fibrosis under hypoxia in canine Sertoli cells. ( Lee, Y; Li, D; Li, X; Wang, W; Wei, H; Wei, J; Xiao, L; Yao, H, 2022) |
| "Retinopathy of prematurity is a vision-threatening disease associated with retinal hypoxia-ischemia, leading to the death of retinal neurons and chronic neuronal degeneration." | 5.62 | Melatonin protects inner retinal neurons of newborn mice after hypoxia-ischemia. ( Cui, K; Huang, R; Liang, X; Lin, J; Liu, Y; Lu, X; Shi, Y; Tang, X; Xu, Y; Ye, D; Yu, S, 2021) |
| "Melatonin treatment significantly attenuated the levels of RVSP, thickness of the arteriolar wall, oxidative and inflammatory markers in the hypoxic animals with a marked increase in the eNOS phosphorylation in the lung." | 5.46 | Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats. ( Fung, ML; Hung, MW; Lau, CF; Poon, AMS; Tipoe, GL; Yeung, HM, 2017) |
| "To test this hypothesis, LNCaP human prostate cancer cells were xenografted into seven-wk-old Foxn1nu/nu male mice that were treated with melatonin (18 i." | 5.40 | Antitumour activity of melatonin in a mouse model of human prostate cancer: relationship with hypoxia signalling. ( Bianciardi, P; Bonomini, F; Favero, G; Finati, E; Fraschini, F; Paroni, R; Reiter, RJ; Rezzani, R; Samaja, M; Terraneo, L; Virgili, E, 2014) |
| "Melatonin treatment significantly mitigated the increased expression of NADPH oxidase, pro-inflammatory mediators, and adhesion molecules." | 5.39 | Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia. ( Fung, ML; Hung, MW; Kravtsov, GM; Lau, CF; Poon, AM; Tipoe, GL, 2013) |
| "Melatonin (MEL) is an endogenous neurohormone with many biological functions, including a powerful antioxidant effect." | 5.39 | Neuroprotective effect of melatonin in experimentally induced hypobaric hypoxia. ( Boşca, B; Crişan, D; Filip, A; Şovrea, A; Stan, N; Vornicescu, C; Yacoob, S, 2013) |
| "Melatonin was administered to another group of mice as a potent ROS scavenger." | 5.37 | Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin. ( Bustos-Obregón, E; Hartley, R; Vargas, A, 2011) |
| "Pre-treatment with melatonin (10(-4) M) showed no significant effect on the vasorelaxation by the nitric oxide donor; sodium nitroprusside (10(-7)-10(-5) M)." | 5.35 | Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery. ( Ballard, HJ; Balonan, L; Das, R; Ho, S, 2008) |
| "Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion." | 5.35 | Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009) |
| "These studies demonstrate a significant neuroprotective efficacy of melatonin in term neonatal models of hypoxia-ischaemia, and suggest melatonin is a strong candidate for translation to clinical trials in babies with moderate-severe NE." | 5.22 | Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia. ( Golay, X; Han, HJ; Meehan, C; Miller, SL; Pang, R; Robertson, NJ, 2022) |
| "Melatonin confers protection against myocardial injury by reducing inflammation and inhibiting apoptosis." | 4.31 | Melatonin attenuates inflammation and cardiac dysfunction in myocardial infarction by regulating the miRNA-200b-3p/high mobility group box chromosomal protein 1 axis. ( Huo, JL; Liu, ZH; Ren, K; Wu, F, 2023) |
| "An oral treatment with melatonin during pregnancy promotes postnatal cerebral perfusion in chronically hypoxic neonates." | 4.12 | Melatonin treatment during chronic hypoxic gestation improves neonatal cerebrovascular function. ( Arias, PV; Candia, AA; Ebensperger, G; González-Candia, A; González-Candia, C; Herrera, EA; Llanos, AJ; Navarrete, A; Reyes, RV, 2022) |
| "Adopting an integrative approach, by combining studies of cardiovascular function with those at cellular and molecular levels, this study investigated whether maternal treatment with melatonin protects against programmed cardiovascular dysfunction in the offspring using an established rodent model of hypoxic pregnancy." | 4.12 | Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy. ( Blanco, CE; Camm, EJ; Galli, GLJ; Giussani, DA; Hansell, JA; Herrera, EA; Lock, MC; Patey, OV; Richter, HG; Trafford, AW; Villamor, E, 2022) |
| "This study aims to investigate the correlation between melatonin and hypoxia induction in cardiomyocytes differentiation." | 4.02 | Melatonin mitigates the adverse effect of hypoxia during myocardial differentiation in mouse embryonic stem cells. ( Jeong, S; Jeung, EB; Lee, B; Lee, JH; Tran, DN; Yoo, YM, 2021) |
| "A high-fat diet (FD)-induced obesity mouse model was subjected to intermittent hypoxia/normoxia events for approximately 8 h per day using an autophagy agonist, rapamycin, or an inhibitor, 3-methyladenine (3-MA), and SRT1720, a sirtuin 1 (SIRT1) activator, or sirtinol, a SIRT1 inhibitor, with or without melatonin for a total of six successive weeks, followed by assessment of expression of autophagy-related genes and activity of serum aminotransferase as well as histological evaluation of tissue morphology." | 3.91 | Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice. ( Han, Y; Jin, M; Li, GC; Liu, HG; Luo, M; Ren, J; You, ZX, 2019) |
| "To determine the effect of melatonin at the transcript level of prostanoid pathways in the lung of neonatal lambs gestated and born under hypobaric hypoxia." | 3.91 | [Melatonin modulates the expression of pulmonary prostanoids]. ( Aguilar, SA; Arias, PV; Canquil, I; Ebensperger, G; González-Candia, A; Herrera, EA; Llanos, AJ; Reyes, RV, 2019) |
| "The study aims to compare, through histological and biochemical studies, the effects of quercetin, melatonin and their combination in regulation of immuno-inflammatory mediators and heat shock protein expressions in sodium nitrite induced hypoxia in rat lungs." | 3.85 | Original research paper. Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats. ( Al-Rasheed, NM; Attia, HA; Fadda, L; Mohamed, AM; Sharaf, IA, 2017) |
| "This study suggests that melatonin may have potential value in the prevention and treatment of various retinal diseases associated with increase of VEGF, vascular leakage and angiogenesis." | 3.85 | Hypoxia-induced vascular endothelial growth factor secretion by retinal pigment epithelial cells is inhibited by melatonin via decreased accumulation of hypoxia-inducible factors-1α protein. ( Chuang, LY; Hu, DN; Lai, YH; Rosen, R; Sassoon, J; Wu, KY; Wu, WC, 2017) |
| "Melatonin has anabolic effects on the bone, even under hypoxia, and laser irradiation has been shown to improve osteoblastic differentiation." | 3.85 | A novel combination treatment to stimulate bone healing and regeneration under hypoxic conditions: photobiomodulation and melatonin. ( Cho, YC; Kim, IR; Kim, JS; Kim, YD; Park, BS; Son, JH; Sung, IY, 2017) |
| " We aimed to investigate the proteins related to oxidative stress, inflammation and apoptosis in liver tissue subjected to IH as a simulation of sleep apnea in conjunction with the administration of either melatonin (MEL, 200 μL/kg) or N-acetylcysteine (NAC, 10 mg/kg)." | 3.81 | Antioxidants inhibit the inflammatory and apoptotic processes in an intermittent hypoxia model of sleep apnea. ( Andrade, CF; da Rosa, DP; e Silva, MB; Fiori, CZ; Forgiarini, LF; Marroni, NP; Martinez, D, 2015) |
| "The present results suggest that melatonin prevents the well-recognized increase in glucose levels that usually follows exposure to intermittent hypoxia." | 3.81 | Melatonin prevents hyperglycemia in a model of sleep apnea. ( Fagundes, M; Fiori, CZ; Kaminski, RS; Marroni, NP; Martinez, D; Martins, EF; Montanari, CC; Rosa, DP, 2015) |
| "Activation of the nitric oxide system and protein nitration constitutes a hippocampal response to hypobaric hypoxia and administration of melatonin could provide new therapeutic avenues to prevent and/or treat the symptoms produced by hypobaric hypoxia." | 3.81 | Effects of melatonin on the nitric oxide system and protein nitration in the hypobaric hypoxic rat hippocampus. ( Chen, KT; Fu, PI; Huang, CC; Jou, MJ; Lai, CJ; Tsai, MH; Wei, IH; Wu, CH; Wu, YC, 2015) |
| "Experimental studies in animal models supporting protective effects on the fetus of melatonin in adverse pregnancy have prompted clinical trials in human pregnancy complicated by fetal growth restriction." | 3.81 | Melatonin modulates the fetal cardiovascular defense response to acute hypoxia. ( Allison, BJ; Botting, KJ; Giussani, DA; Herrera, EA; Niu, Y; Serón-Ferré, M; Thakor, AS, 2015) |
| "Experiments with mice showed that in a multitude of acute hypoxia models (normobaric hypoxic hypoxia with hypercapnia, hypobaric, hemic and histotaxic) the antihypoxic action of a single intra-abdominal dose of melatonin surpasses greatly amtisol, the standard antihypoxic agent." | 3.81 | [STUDIES OF THE ANTIHYPOXIC AND ANTIAMNESTIC EFFECTS OF MELATONIN IN ANIMALS]. ( Chelnaya, NA; Ivanov, YV; Karsanova, SK; Motin, VG; Yasnetsov, VV, 2015) |
| "Melatonin seems to exert a protective effect on arteries from both ob/ob and CLM, counteracting the adverse effect of hypoxia and iberiotoxin." | 3.80 | Anticontractile activity of perivascular fat in obese mice and the effect of long-term treatment with melatonin. ( Agabiti-Rosei, C; Agabiti-Rosei, E; De Ciuceis, C; Favero, G; Heagerty, AM; Porteri, E; Rezzani, R; Rizzoni, D; Rodella, LF; Rossini, C; Withers, SB, 2014) |
| " We tested the hypothesis that melatonin ameliorates the CIH-induced lipid peroxidation, local inflammation and cellular injury in rat adrenal medulla." | 3.80 | Melatonin attenuates intermittent hypoxia-induced lipid peroxidation and local inflammation in rat adrenal medulla. ( Fung, ML; Liu, Y; Tipoe, GL, 2014) |
| "To investigate the neuroprotective effect of melatonin against chronic intermittent hypoxia (CIH), the major pathophysiologic features of obstructive sleep apnea syndrome." | 3.79 | Melatonin attenuates hippocampal neuron apoptosis and oxidative stress during chronic intermittent hypoxia via up-regulating B-cell lymphoma-2 and down-regulating B-cell lymphoma-2-associated X protein. ( Guo, X; Liu, H; Tan, X, 2013) |
| "In cytosol from liver of pacu, Piaractus mesopotamicus, a hypoxia-tolerant fish that dwells in Pantanal, we found an enzyme activity capable of modulating the alkenal 4-hydroxy-2-nonenal (HNE) by conjugating it with glutathione (GST-HNE activity)." | 3.79 | Melatonin affects conjugation of 4-hydroxynonenal with glutathione in liver of pacu, a hypoxia-tolerant fish. ( Bastos, FF; Bastos, JC; Bastos, VL; Dantas, RF; Nogueira, NP; Paes, MC; Righi, BD; Silva, ES; Tobar, SA, 2013) |
| "The effects of melatonin and epithalamin on the content of protein and lipid peroxidation products in the cortex and hippocampus of hypoxic rats were studied under conditions of acute hypobaric hypoxia equivalent to the altitude of 12,000 m." | 3.78 | Effects of melatonin and epithalamin on the content of protein and lipid peroxidation products in rat cortex and hippocampus under conditions of acute hypoxia. ( Khavinson, VKh; Sopova, IY; Zamorskii, II, 2012) |
| "We designed the present study to evaluate the efficacy of melatonin (M) on the severity of necrotizing enterocolitis (NEC) in a neonatal rat model." | 3.77 | Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model. ( Gundogdu, G; Guven, A; Korkmaz, A; Oztas, E; Ozturk, H; Uysal, B, 2011) |
| " We tested the sensitivity of PT to preconditioning with hypobaric hypoxia and to pretreatment with melatonin." | 3.74 | Influence of melatonin pretreatment and preconditioning by hypobaric hypoxia on the development of cortical photothrombotic ischemic lesion. ( Bernášková, K; Krýsl, D; Mares, J; Matějovská, I, 2008) |
| " Given that the antioxidant melatonin significantly decreased SCI-induced AQP-1 increases and that hypoxia inducible factor-1alpha was increased in acutely and chronically injured spinal cords, we propose that chronic hypoxia contributes to persistent AQP-1 increases after SCI." | 3.74 | Aquaporin 1 - a novel player in spinal cord injury. ( Hulsebosch, CE; Johnson, K; Lee, J; Nesic, O; Perez-Polo, JR; Unabia, GC; Vergara, L; Ye, Z, 2008) |
| "Melatonin protects against hippocampal injury induced by intermittent hypoxia (IH)." | 3.74 | Melatonin ameliorates hippocampal nitric oxide production and large conductance calcium-activated potassium channel activity in chronic intermittent hypoxia. ( Fung, ML; Hung, MW; Li, MF; Tjong, YW, 2008) |
| "We studied the effect of melatonin on the relationship between LPO intensity and proteolytic activity in basal nuclei (caudate nucleus, globus pallidus, amygdaloid complex, and nucleus accumbens septi) of rat brain during acute hypobaric hypoxia." | 3.73 | Effect of melatonin on the relationship between lipid peroxidation and proteolytic activity in basal nuclei of rat brain during acute hypoxia. ( Sopova, IY; Zamorskii, II, 2006) |
| " Thus, the present study was designed to determine the effects of hypoxia and reoxygenation on the levels of lipid peroxidation and the morphological changes in the liver of male mice as well as the protective role of melatonin as an antioxidant." | 3.73 | Role of melatonin in reducing hypoxia-induced oxidative stress and morphological changes in the liver of male mice. ( El-Sokkary, GH; Khidr, BM; Younes, HA, 2006) |
| "Groups of 6 specimens each of the newt Triturus carnifex were treated with melatonin to see if the hormone inhibited melanogenesis in the Kupffer cells of the liver (melanomacrophages), a process markedly stimulated by hypoxia." | 3.72 | Melatonin, melanogenesis, and hypoxic stress in the newt, Triturus carnifex. ( Bianchi, S; Borgioli, G; Frangioni, G, 2003) |
| " Chronic hypoxia was induced pharmacologically by the administration of the anticonvulsant phenytoin (PHT) during pregnancy." | 3.72 | Effect of melatonin on biochemical variables induced by phenytoin in organs of mothers, foetuses and offsprings of rats. ( Dubovický, M; Mach, M; Navarová, J; Ujházy, E, 2004) |
| " Chronic hypoxia was induced pharmacologically by the administration of the anticonvulsant phenytoin (PHT) during the entire period of pregnancy." | 3.72 | Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration. ( Brucknerová, I; Dubovický, M; Juránek, I; Mach, M; Navarová, J; Soltés, L; Ujházy, E; Zeman, M, 2004) |
| "Melatonin effectively reduced damage induced by chemical hypoxia in adult cardiomyocytes, probably by virtue of its effects on reactive oxygen species generation and intracellular Ca2+ accumulation." | 3.71 | Melatonin protects against ischaemic-reperfusion myocardial damage. ( Cillie, C; Genade, S; Harper, I; Huisamen, B; Lochner, A; Moolman, J; Salie, R, 2001) |
| "Single intraperitoneal injection of melatonin in a dose of 1 mg/kg prevented accumulation of cGMP and intensification of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypobaric hypoxia (12,000 m)." | 3.70 | Effect of melatonin on cyclic nucleotide content and intensity of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypoxia. ( Pishak, VP; Zamorskii, II, 2000) |
| "Hypoxia has an important role in tumor progression via the up-regulation of growth factors and cellular adaptation genes." | 2.72 | Melatonin as a Therapeutic Agent for the Inhibition of Hypoxia-Induced Tumor Progression: A Description of Possible Mechanisms Involved. ( Akbarzadeh, M; Bastani, S; Farzane, A; Fattahi, A; Mollapour Sisakht, M; Nouri, M; Rastgar Rezaei, Y; Reiter, RJ, 2021) |
| "Two types of human hepatoma cell lines were used to explore the mechanism by which melatonin prevents the growth and metastasis of cancer cells in vitro." | 1.91 | Efficacy, mechanism, and safety of melatonin-loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: A novel design. ( Chen, L; Guo, X; Huang, J; Li, X; Liang, B; Liu, Y; Lu, X; Lv, Y; Qian, K; Sun, B; Sun, T; Zhang, H; Zhang, W; Zhao, H; Zhao, Y; Zheng, C; Zhu, L, 2023) |
| "The hypoxic microenvironment of cryptorchidism is an important factor in the impairment and fibrosis of Sertoli cells which result in blood-testis barrier (BTB) destruction and spermatogenesis loss." | 1.72 | Melatonin through blockade of Hif-1α signaling mediates the anti-fibrosis under hypoxia in canine Sertoli cells. ( Lee, Y; Li, D; Li, X; Wang, W; Wei, H; Wei, J; Xiao, L; Yao, H, 2022) |
| "Melatonin posttreatment (t = -15, 0, 5, 10, 15, and 30 min) significantly inhibited excessive mitophagy after A/R injury, reduced cellular apoptosis and oxidative stress, restored mitochondrial function and MMP, and restrained mPTP opening." | 1.72 | Temporal effect of melatonin posttreatment on anoxia/reoxygenation injury in H9c2 cells. ( Bai, Y; Cui, B; Lin, D; Ma, J; Wang, Z; Yang, Y, 2022) |
| "Melatonin has received attention as a potential antifibrotic agent due to its anti-proliferative actions on PSCs." | 1.72 | Melatonin modulates metabolic adaptation of pancreatic stellate cells subjected to hypoxia. ( Estaras, M; Garcia, A; Gonzalez, A; Iovanna, JL; Martinez, R; Ortiz-Placin, C; Santofimia-Castaño, P, 2022) |
| "Retinopathy of prematurity is a vision-threatening disease associated with retinal hypoxia-ischemia, leading to the death of retinal neurons and chronic neuronal degeneration." | 1.62 | Melatonin protects inner retinal neurons of newborn mice after hypoxia-ischemia. ( Cui, K; Huang, R; Liang, X; Lin, J; Liu, Y; Lu, X; Shi, Y; Tang, X; Xu, Y; Ye, D; Yu, S, 2021) |
| "Melatonin is a neurohormone with antioxidant and vasodilator properties at the pulmonary level." | 1.56 | Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates. ( Aguilar, SA; Candia, AA; Ebensperger, G; Feixes, E; Figueroa, EG; Gonzaléz-Candia, A; Gonzalez-Candia, C; Herrera, EA; Llanos, AJ; Reyes, RV, 2020) |
| " This information, coupled with pharmacokinetic data, will help to define the therapeutic dosage of melatonin in vivo and, ultimately, in patients." | 1.48 | Melatonin Acts in Synergy with Hypothermia to Reduce Oxygen-Glucose Deprivation-Induced Cell Death in Rat Hippocampus Organotypic Slice Cultures. ( Balduini, W; Buonocore, G; Carloni, S; Facchinetti, F; Pelizzi, N, 2018) |
| "Melatonin treatment significantly attenuated the levels of RVSP, thickness of the arteriolar wall, oxidative and inflammatory markers in the hypoxic animals with a marked increase in the eNOS phosphorylation in the lung." | 1.46 | Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats. ( Fung, ML; Hung, MW; Lau, CF; Poon, AMS; Tipoe, GL; Yeung, HM, 2017) |
| "To test this hypothesis, LNCaP human prostate cancer cells were xenografted into seven-wk-old Foxn1nu/nu male mice that were treated with melatonin (18 i." | 1.40 | Antitumour activity of melatonin in a mouse model of human prostate cancer: relationship with hypoxia signalling. ( Bianciardi, P; Bonomini, F; Favero, G; Finati, E; Fraschini, F; Paroni, R; Reiter, RJ; Rezzani, R; Samaja, M; Terraneo, L; Virgili, E, 2014) |
| "Melatonin has a cellular protective effect in cerebrovascular and neurodegenerative diseases." | 1.40 | The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion-induced injury. ( Kang, SM; Lee, JE; Lee, KM; Lee, WT; Park, KA; Song, J, 2014) |
| "Melatonin is a potential therapeutic agent for treating cerebrovascular dysfunction associated with oxidative stress and developmental hypoxia in neonates." | 1.40 | Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs. ( Díaz, M; Ebensperger, G; Herrera, EA; Llanos, AJ; Macchiavello, R; Montt, C; Parer, JT; Ramírez, S; Reyes, RV; Serón-Ferré, M, 2014) |
| "Melatonin treatment significantly mitigated the increased expression of NADPH oxidase, pro-inflammatory mediators, and adhesion molecules." | 1.39 | Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia. ( Fung, ML; Hung, MW; Kravtsov, GM; Lau, CF; Poon, AM; Tipoe, GL, 2013) |
| "Melatonin (MEL) is an endogenous neurohormone with many biological functions, including a powerful antioxidant effect." | 1.39 | Neuroprotective effect of melatonin in experimentally induced hypobaric hypoxia. ( Boşca, B; Crişan, D; Filip, A; Şovrea, A; Stan, N; Vornicescu, C; Yacoob, S, 2013) |
| "Melatonin was also applied before hypoxia to influence free radical (FR) production and intrinsic antioxidant activation." | 1.38 | An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin. ( Deykun, K; Krýsl, D; Mareš, J; Pometlová, M; Rokyta, R, 2012) |
| "Melatonin was administered to another group of mice as a potent ROS scavenger." | 1.37 | Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin. ( Bustos-Obregón, E; Hartley, R; Vargas, A, 2011) |
| "Pre-treatment with melatonin (10(-4) M) showed no significant effect on the vasorelaxation by the nitric oxide donor; sodium nitroprusside (10(-7)-10(-5) M)." | 1.35 | Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery. ( Ballard, HJ; Balonan, L; Das, R; Ho, S, 2008) |
| "Melatonin treatment significantly mitigated the calcium handling in the hypoxic rats by preserving SERCA expression." | 1.35 | Melatonin ameliorates calcium homeostasis in myocardial and ischemia-reperfusion injury in chronically hypoxic rats. ( Fung, ML; Hung, MW; Yeung, HM, 2008) |
| "Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion." | 1.35 | Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009) |
| "In melatonin pretreated rats, the hypoxia-induced reduction of COX reactivity was obviously prevented and the augmentation of NOS/NADPH-d reactivity was successfully suppressed." | 1.33 | Melatonin restores the cytochrome oxidase reactivity in the nodose ganglia of acute hypoxic rats. ( Chang, HM; Lue, JH; Shieh, JY; Tseng, CY; Wei, IH; Wen, CY, 2005) |
| "Melatonin has a number of physiological functions in addition to light-dark transduction." | 1.33 | Effects of melatonin administration on oxidative stress and daily locomotor activity patterns in goldfish. ( Bayarri, MJ; López-Olmeda, JF; Madrid, JA; Rol de Lama, MA; Sánchez-Vázquez, FJ, 2006) |
| "CO-induced hypoxemia is an important aspect in any discussion of cell integrity as CO is formed endogenously from the degradation of erythrocytic heme, any hemolytic disturbance or lipid peroxidation, may increase the level in blood." | 1.32 | Role of melatonin in carbon monoxide-induced hypoxemia. ( Nicholls, JC, 2004) |
| "Fatigue is often reported after long duration flights." | 1.32 | Hypoxic depression of melatonin secretion after simulated long duration flights in man. ( Batéjat, D; Beaumont, M; Charbuy, H; Coste, O; Touitou, Y; Van Beers, P, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 30 (31.58) | 29.6817 |
| 2010's | 42 (44.21) | 24.3611 |
| 2020's | 23 (24.21) | 2.80 |
| Authors | Studies |
|---|---|
| Özşimşek, A | 1 |
| Nazıroğlu, M | 1 |
| Hansell, JA | 1 |
| Richter, HG | 1 |
| Camm, EJ | 1 |
| Herrera, EA | 7 |
| Blanco, CE | 1 |
| Villamor, E | 1 |
| Patey, OV | 1 |
| Lock, MC | 1 |
| Trafford, AW | 1 |
| Galli, GLJ | 1 |
| Giussani, DA | 2 |
| Bastani, S | 1 |
| Akbarzadeh, M | 2 |
| Rastgar Rezaei, Y | 1 |
| Farzane, A | 1 |
| Nouri, M | 1 |
| Mollapour Sisakht, M | 1 |
| Fattahi, A | 1 |
| Reiter, RJ | 4 |
| Bai, Y | 1 |
| Yang, Y | 2 |
| Cui, B | 1 |
| Lin, D | 1 |
| Wang, Z | 1 |
| Ma, J | 1 |
| Candia, AA | 2 |
| Arias, PV | 2 |
| González-Candia, C | 2 |
| Navarrete, A | 1 |
| Ebensperger, G | 4 |
| Reyes, RV | 4 |
| Llanos, AJ | 4 |
| González-Candia, A | 4 |
| Hosseinzadeh, MH | 1 |
| Goodarzi, A | 1 |
| Malekan, M | 1 |
| Ebrahimzadeh, MA | 1 |
| Pang, R | 2 |
| Han, HJ | 1 |
| Meehan, C | 1 |
| Golay, X | 1 |
| Miller, SL | 1 |
| Robertson, NJ | 2 |
| Estaras, M | 1 |
| Martinez, R | 1 |
| Garcia, A | 1 |
| Ortiz-Placin, C | 1 |
| Iovanna, JL | 1 |
| Santofimia-Castaño, P | 1 |
| Gonzalez, A | 1 |
| Huang, YB | 1 |
| Jiang, L | 1 |
| Liu, XQ | 1 |
| Wang, X | 2 |
| Gao, L | 1 |
| Zeng, HX | 1 |
| Zhu, W | 1 |
| Hu, XR | 1 |
| Wu, YG | 1 |
| Wei, H | 1 |
| Xiao, L | 1 |
| Yao, H | 1 |
| Li, X | 3 |
| Wang, W | 1 |
| Lee, Y | 1 |
| Li, D | 1 |
| Wei, J | 1 |
| Zhang, Y | 2 |
| Chen, D | 1 |
| Wang, Y | 2 |
| Zhang, Z | 2 |
| Xin, Y | 1 |
| Yang, H | 1 |
| Ding, X | 1 |
| Jiang, X | 1 |
| Tan, L | 1 |
| Lin, C | 1 |
| Xu, L | 1 |
| Li, G | 1 |
| Lu, L | 1 |
| Qin, Z | 1 |
| Feng, X | 1 |
| Li, M | 1 |
| Sabir, H | 1 |
| Maes, E | 1 |
| Zweyer, M | 1 |
| Schleehuber, Y | 1 |
| Imam, FB | 1 |
| Silverman, J | 1 |
| White, Y | 1 |
| Pasca, AM | 1 |
| Maltepe, E | 1 |
| Bernis, ME | 1 |
| Chen, L | 1 |
| Sun, T | 1 |
| Lv, Y | 1 |
| Lu, X | 2 |
| Zhang, H | 1 |
| Qian, K | 1 |
| Guo, X | 2 |
| Sun, B | 1 |
| Zhang, W | 1 |
| Zhu, L | 1 |
| Huang, J | 1 |
| Liu, Y | 3 |
| Zhao, H | 1 |
| Zhao, Y | 1 |
| Liang, B | 1 |
| Zheng, C | 1 |
| Wang, F | 3 |
| Gao, Z | 1 |
| Huang, W | 1 |
| Zhang, X | 1 |
| Liu, F | 1 |
| Yi, H | 1 |
| Guan, J | 1 |
| Wu, X | 1 |
| Xu, H | 1 |
| Yin, S | 1 |
| Liu, ZH | 1 |
| Wu, F | 1 |
| Ren, K | 1 |
| Huo, JL | 1 |
| Figueroa, EG | 1 |
| Feixes, E | 1 |
| Aguilar, SA | 2 |
| Merlo, S | 1 |
| Luaces, JP | 1 |
| Spampinato, SF | 1 |
| Toro-Urrego, N | 1 |
| Caruso, GI | 1 |
| D'Amico, F | 1 |
| Capani, F | 1 |
| Sortino, MA | 1 |
| Rivera, E | 1 |
| García-Herrera, C | 1 |
| Celentano, DJ | 1 |
| Huang, R | 1 |
| Xu, Y | 1 |
| Tang, X | 1 |
| Lin, J | 1 |
| Cui, K | 1 |
| Yu, S | 1 |
| Shi, Y | 1 |
| Ye, D | 1 |
| Liang, X | 1 |
| Frajewicki, A | 1 |
| Laštůvka, Z | 1 |
| Borbélyová, V | 1 |
| Khan, S | 1 |
| Jandová, K | 1 |
| Janišová, K | 1 |
| Otáhal, J | 1 |
| Mysliveček, J | 1 |
| Riljak, V | 1 |
| Lee, JH | 2 |
| Yoo, YM | 1 |
| Lee, B | 1 |
| Jeong, S | 1 |
| Tran, DN | 1 |
| Jeung, EB | 1 |
| Li, W | 1 |
| Liu, B | 1 |
| Wang, L | 2 |
| Liu, J | 1 |
| Yang, X | 1 |
| Zheng, J | 1 |
| Hung, MW | 6 |
| Yeung, HM | 3 |
| Lau, CF | 4 |
| Poon, AMS | 1 |
| Tipoe, GL | 5 |
| Fung, ML | 9 |
| Carloni, S | 1 |
| Facchinetti, F | 1 |
| Pelizzi, N | 1 |
| Buonocore, G | 1 |
| Balduini, W | 1 |
| de Aquino Lemos, V | 1 |
| Dos Santos, RVT | 1 |
| Antunes, HKM | 1 |
| Behn, C | 1 |
| Viscor, G | 1 |
| Lira, FS | 1 |
| Bittar, IGL | 1 |
| Caris, AV | 1 |
| Tufik, S | 1 |
| De Mello, MT | 1 |
| Ren, J | 2 |
| Jin, M | 1 |
| You, ZX | 1 |
| Luo, M | 1 |
| Han, Y | 1 |
| Li, GC | 1 |
| Liu, HG | 2 |
| Cheng, J | 1 |
| Yang, HL | 1 |
| Gu, CJ | 1 |
| Liu, YK | 1 |
| Shao, J | 1 |
| Zhu, R | 1 |
| He, YY | 1 |
| Zhu, XY | 1 |
| Li, MQ | 1 |
| Yalcin, E | 1 |
| Beker, MC | 1 |
| Turkseven, S | 1 |
| Caglayan, B | 1 |
| Gurel, B | 1 |
| Kilic, U | 1 |
| Caglayan, AB | 1 |
| Kalkan, R | 1 |
| Baykal, AT | 1 |
| Kelestemur, T | 1 |
| Kilic, E | 1 |
| Canquil, I | 1 |
| Bastos, FF | 1 |
| Tobar, SA | 1 |
| Dantas, RF | 1 |
| Silva, ES | 1 |
| Nogueira, NP | 1 |
| Paes, MC | 1 |
| Righi, BD | 1 |
| Bastos, JC | 1 |
| Bastos, VL | 1 |
| Liu, Q | 1 |
| Ling, EA | 7 |
| Liu, S | 1 |
| Yao, L | 1 |
| Chen, X | 1 |
| Shi, W | 1 |
| Gao, M | 1 |
| Hao, A | 1 |
| Hemadi, M | 1 |
| Shokri, S | 1 |
| Moramezi, F | 1 |
| Nikbakht, R | 1 |
| Sobhani, A | 1 |
| Tan, X | 1 |
| Liu, H | 1 |
| Kravtsov, GM | 1 |
| Poon, AM | 2 |
| Vornicescu, C | 1 |
| Boşca, B | 1 |
| Crişan, D | 1 |
| Yacoob, S | 1 |
| Stan, N | 1 |
| Filip, A | 1 |
| Şovrea, A | 1 |
| Agabiti-Rosei, C | 1 |
| De Ciuceis, C | 1 |
| Rossini, C | 1 |
| Porteri, E | 1 |
| Rodella, LF | 1 |
| Withers, SB | 1 |
| Heagerty, AM | 1 |
| Favero, G | 2 |
| Agabiti-Rosei, E | 1 |
| Rizzoni, D | 1 |
| Rezzani, R | 2 |
| Paroni, R | 1 |
| Terraneo, L | 1 |
| Bonomini, F | 1 |
| Finati, E | 1 |
| Virgili, E | 1 |
| Bianciardi, P | 1 |
| Fraschini, F | 1 |
| Samaja, M | 1 |
| Macchiavello, R | 1 |
| Montt, C | 1 |
| Díaz, M | 1 |
| Ramírez, S | 1 |
| Parer, JT | 1 |
| Serón-Ferré, M | 2 |
| Song, J | 1 |
| Kang, SM | 1 |
| Lee, WT | 1 |
| Park, KA | 1 |
| Lee, KM | 1 |
| Lee, JE | 1 |
| Jin, H | 1 |
| Zhou, L | 1 |
| Liu, L | 1 |
| Zhang, P | 1 |
| Deng, W | 1 |
| Yuan, Y | 1 |
| da Rosa, DP | 1 |
| Forgiarini, LF | 1 |
| e Silva, MB | 1 |
| Fiori, CZ | 2 |
| Andrade, CF | 1 |
| Martinez, D | 2 |
| Marroni, NP | 2 |
| Thakor, AS | 1 |
| Allison, BJ | 1 |
| Niu, Y | 1 |
| Botting, KJ | 1 |
| Kaminski, RS | 1 |
| Fagundes, M | 1 |
| Martins, EF | 1 |
| Montanari, CC | 1 |
| Rosa, DP | 1 |
| Eom, KS | 1 |
| Song, DK | 1 |
| Suh, SI | 1 |
| Kim, DK | 1 |
| Xie, S | 1 |
| Deng, Y | 1 |
| Pan, YY | 1 |
| Wang, ZH | 1 |
| Guo, XL | 1 |
| Yuan, X | 1 |
| Shang, J | 1 |
| Huang, CC | 1 |
| Lai, CJ | 1 |
| Tsai, MH | 1 |
| Wu, YC | 1 |
| Chen, KT | 1 |
| Jou, MJ | 1 |
| Fu, PI | 1 |
| Wu, CH | 1 |
| Wei, IH | 2 |
| Yasnetsov, VV | 2 |
| Motin, VG | 1 |
| Karsanova, SK | 1 |
| Ivanov, YV | 1 |
| Chelnaya, NA | 1 |
| Geihs, MA | 1 |
| Vargas, MA | 1 |
| Maciel, FE | 1 |
| Vakkuri, O | 1 |
| Meyer-Rochow, VB | 1 |
| Allodi, S | 1 |
| Nery, LE | 1 |
| Lai, YH | 1 |
| Hu, DN | 1 |
| Rosen, R | 1 |
| Sassoon, J | 1 |
| Chuang, LY | 1 |
| Wu, KY | 1 |
| Wu, WC | 1 |
| Son, JH | 1 |
| Park, BS | 1 |
| Kim, IR | 1 |
| Sung, IY | 1 |
| Cho, YC | 1 |
| Kim, JS | 1 |
| Kim, YD | 1 |
| Al-Rasheed, NM | 2 |
| Fadda, L | 1 |
| Attia, HA | 1 |
| Sharaf, IA | 1 |
| Mohamed, AM | 1 |
| Bertuglia, S | 1 |
| Kaur, C | 5 |
| Sivakumar, V | 4 |
| Foulds, WS | 2 |
| Luu, CD | 1 |
| Coste, O | 2 |
| Van Beers, P | 2 |
| Touitou, Y | 2 |
| Lu, J | 3 |
| Kekec, Z | 1 |
| Seydaoglul, G | 1 |
| Sever, H | 1 |
| Ozturk, F | 1 |
| Ng, KM | 1 |
| Viswanathan, S | 1 |
| Guven, A | 1 |
| Uysal, B | 1 |
| Gundogdu, G | 1 |
| Oztas, E | 1 |
| Ozturk, H | 1 |
| Korkmaz, A | 1 |
| Ramond, A | 1 |
| Godin-Ribuot, D | 1 |
| Ribuot, C | 1 |
| Totoson, P | 1 |
| Koritchneva, I | 1 |
| Cachot, S | 1 |
| Levy, P | 1 |
| Joyeux-Faure, M | 1 |
| Mareš, J | 2 |
| Pometlová, M | 1 |
| Deykun, K | 1 |
| Krýsl, D | 2 |
| Rokyta, R | 1 |
| Vargas, A | 1 |
| Bustos-Obregón, E | 1 |
| Hartley, R | 1 |
| Farías, JG | 1 |
| Zepeda, AB | 1 |
| Calaf, GM | 1 |
| Ali, SA | 1 |
| Aly, HF | 1 |
| Faddah, LM | 1 |
| Zaidi, ZF | 1 |
| Zamorskii, II | 3 |
| Sopova, IY | 2 |
| Khavinson, VKh | 1 |
| Frangioni, G | 1 |
| Borgioli, G | 1 |
| Bianchi, S | 1 |
| Dubovický, M | 3 |
| Ujházy, E | 3 |
| Kovacovský, P | 1 |
| Navarová, J | 3 |
| Juráni, M | 1 |
| Soltés, L | 2 |
| Mach, M | 2 |
| Juránek, I | 1 |
| Brucknerová, I | 1 |
| Zeman, M | 1 |
| Beaumont, M | 1 |
| Batéjat, D | 1 |
| Charbuy, H | 1 |
| Nicholls, JC | 1 |
| Chen, Y | 1 |
| Tjong, YW | 2 |
| Ip, SF | 1 |
| Seebacher, F | 1 |
| Franklin, CE | 1 |
| Chang, HM | 2 |
| Tseng, CY | 1 |
| Lue, JH | 1 |
| Wen, CY | 2 |
| Shieh, JY | 2 |
| El-Sokkary, GH | 1 |
| Khidr, BM | 1 |
| Younes, HA | 1 |
| López-Olmeda, JF | 1 |
| Bayarri, MJ | 1 |
| Rol de Lama, MA | 1 |
| Madrid, JA | 1 |
| Sánchez-Vázquez, FJ | 1 |
| Payne, AG | 1 |
| Matějovská, I | 1 |
| Bernášková, K | 1 |
| Yong, Z | 1 |
| Das, R | 1 |
| Balonan, L | 1 |
| Ballard, HJ | 1 |
| Ho, S | 1 |
| Nesic, O | 1 |
| Lee, J | 1 |
| Unabia, GC | 1 |
| Johnson, K | 1 |
| Ye, Z | 1 |
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| Hulsebosch, CE | 1 |
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| Peers, C | 1 |
| Chen, CF | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Melatonin and Essential Arterial Hypertension[NCT05257291] | Phase 2 | 23 participants (Actual) | Interventional | 2018-02-02 | Active, not recruiting | ||
| A Pilot, Open-label Study to Evaluate the Effects of a Prostate Health Formulation on Scores Attained From the International Prostate Symptom Score (I-PSS) Questionnaire Among Overall Healthy Male Participants Who Report Lower Urinary Tract Complaints[NCT02886832] | 30 participants (Anticipated) | Interventional | 2016-09-21 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for melatonin and Hypoxia
| Article | Year |
|---|---|
Melatonin as a Therapeutic Agent for the Inhibition of Hypoxia-Induced Tumor Progression: A Description of Possible Mechanisms Involved.
Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Humans; Hypoxia; Melatonin; Neoplasms; Neovas | 2021 |
Efficacy of melatonin in term neonatal models of perinatal hypoxia-ischaemia.
Topics: Animals; Brain Diseases; Humans; Hypothermia, Induced; Hypoxia; Infant, Newborn; Infant, Newborn, Di | 2022 |
Perinatal hypoxic-ischemic damage: review of the current treatment possibilities.
Topics: Central Nervous System Depressants; Erythropoietin; Female; Humans; Hypoxia; Hypoxia-Ischemia, Brain | 2020 |
Physiological mechanisms of thermoregulation in reptiles: a review.
Topics: Animals; Behavior, Animal; Body Temperature Regulation; Cardiovascular Physiological Phenomena; Envi | 2005 |
1 trial available for melatonin and Hypoxia
| Article | Year |
|---|---|
Melatonin and sleep responses to normobaric hypoxia and aerobic physical exercise: A randomized controlled trial.
Topics: Adult; Exercise; Humans; Hypoxia; Male; Melatonin; Oxygen; Photoperiod; Sleep; Young Adult | 2018 |
90 other studies available for melatonin and Hypoxia
| Article | Year |
|---|---|
The involvement of TRPV4 on the hypoxia-induced oxidative neurotoxicity and apoptosis in a neuronal cell line: Protective role of melatonin.
Topics: Apoptosis; Blotting, Western; Cell Line; HEK293 Cells; Humans; Hypoxia; Melatonin; Neurons; Neuropro | 2021 |
Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy.
Topics: Animals; Female; Fetal Growth Retardation; Hypoxia; Melatonin; Pregnancy; Pregnancy Complications; R | 2022 |
Temporal effect of melatonin posttreatment on anoxia/reoxygenation injury in H9c2 cells.
Topics: Apoptosis; Humans; Hypoxia; Melatonin; Mitophagy; Myocardial Reperfusion Injury; Myocytes, Cardiac | 2022 |
Melatonin treatment during chronic hypoxic gestation improves neonatal cerebrovascular function.
Topics: Animals; Antioxidants; Female; Hypoxia; Lung; Melatonin; Oxidative Stress; Pregnancy; Sheep | 2022 |
Melatonin increased hypoxia-inducible factor (HIF) by inhibiting prolyl hydroxylase: A hypothesis for treating anaemia, ischaemia, and covid-19.
Topics: Anemia; COVID-19; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Melatonin; P | 2022 |
Melatonin modulates metabolic adaptation of pancreatic stellate cells subjected to hypoxia.
Topics: Actins; Cells, Cultured; Collagen; Fibrosis; Humans; Hypoxia; Melatonin; Pancreas; Pancreatic Stella | 2022 |
Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis.
Topics: Acute Kidney Injury; Animals; Ferroptosis; Folic Acid; Hypoxia; Melatonin; Mice; NF-E2-Related Facto | 2022 |
Melatonin through blockade of Hif-1α signaling mediates the anti-fibrosis under hypoxia in canine Sertoli cells.
Topics: Acetylserotonin O-Methyltransferase; Animals; Cryptorchidism; Dogs; Fibrosis; Hypoxia; Hypoxia-Induc | 2022 |
Neuroprotective effects of melatonin-mediated mitophagy through nucleotide-binding oligomerization domain and leucine-rich repeat-containing protein X1 in neonatal hypoxic-ischemic brain damage.
Topics: Beclin-1; Brain; Glucose; Humans; Hypoxia; Hypoxia-Ischemia, Brain; Infant, Newborn; Leucine; Melato | 2023 |
RP58 knockdown contributes to hypoxia-ischemia-induced pineal dysfunction and circadian rhythm disruption in neonatal rats.
Topics: Animals; Animals, Newborn; ARNTL Transcription Factors; Arylalkylamine N-Acetyltransferase; Circadia | 2023 |
Comparing the efficacy in reducing brain injury of different neuroprotective agents following neonatal hypoxia-ischemia in newborn rats: a multi-drug randomized controlled screening trial.
Topics: Allopurinol; Animals; Animals, Newborn; Asphyxia Neonatorum; Brain; Brain Injuries; Caffeine; Clemas | 2023 |
Efficacy, mechanism, and safety of melatonin-loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: A novel design.
Topics: Animals; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Humans; Hypoxia; Liver Neoplasms | 2023 |
Melatonin attenuates chronic intermittent hypoxia-induced intestinal barrier dysfunction in mice.
Topics: Animals; Caco-2 Cells; Cytokines; Dysbiosis; Gastrointestinal Diseases; Humans; Hypoxia; Melatonin; | 2023 |
Melatonin attenuates inflammation and cardiac dysfunction in myocardial infarction by regulating the miRNA-200b-3p/high mobility group box chromosomal protein 1 axis.
Topics: Animals; Apoptosis; HMGB1 Protein; Hypoxia; Inflammation; Melatonin; MicroRNAs; Myocardial Infarctio | 2023 |
Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic hypoxic ovine neonates.
Topics: Animals; Animals, Newborn; Antioxidants; Arterial Pressure; Hypertension, Pulmonary; Hypoxia; Lung; | 2020 |
SIRT1 Mediates Melatonin's Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence.
Topics: Animals; Cell Line; Cells, Cultured; Humans; Hypoxia; Melatonin; Microglia; Neuroprotective Agents; | 2020 |
Effects of melatonin on the passive mechanical response of arteries in chronic hypoxic newborn lambs.
Topics: Animals; Animals, Newborn; Hypertension, Pulmonary; Hypoxia; Melatonin; Pulmonary Artery; Sheep | 2020 |
Melatonin protects inner retinal neurons of newborn mice after hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Hypoxia; Ischemia; Melatonin; Mice; Mice, Inbred C57BL; Neuroprotective A | 2021 |
Melatonin mitigates the adverse effect of hypoxia during myocardial differentiation in mouse embryonic stem cells.
Topics: Animals; Biomarkers; Cell Differentiation; Embryonic Stem Cells; Gene Expression Regulation; Heart; | 2021 |
Melatonin Attenuates Cardiac Ischemia-Reperfusion Injury through Modulation of IP3R-Mediated Mitochondria-ER Contact.
Topics: Animals; Antioxidants; Endoplasmic Reticulum Stress; Hypoxia; Inositol 1,4,5-Trisphosphate Receptors | 2021 |
Melatonin Attenuates Pulmonary Hypertension in Chronically Hypoxic Rats.
Topics: Animals; Antioxidants; Chronic Disease; Hypertension, Pulmonary; Hypoxia; Inflammation; Lung; Melato | 2017 |
Melatonin Acts in Synergy with Hypothermia to Reduce Oxygen-Glucose Deprivation-Induced Cell Death in Rat Hippocampus Organotypic Slice Cultures.
Topics: Animals; Animals, Newborn; Cell Death; Glucose; Hippocampus; Hypothermia, Induced; Hypoxia; Hypoxia- | 2018 |
Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice.
Topics: Animals; Autophagy; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Fe | 2019 |
Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF.
Topics: Biomarkers; Cell Line, Tumor; Cell Survival; Cells, Cultured; Endothelial Cells; Human Umbilical Vei | 2019 |
Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival.
Topics: Animals; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Down-Regulation; Gas Ch | 2019 |
[Melatonin modulates the expression of pulmonary prostanoids].
Topics: Animals; Animals, Newborn; Antioxidants; Hypertension, Pulmonary; Hypoxia; Melatonin; Oxidative Stre | 2019 |
Melatonin affects conjugation of 4-hydroxynonenal with glutathione in liver of pacu, a hypoxia-tolerant fish.
Topics: Aldehydes; Analysis of Variance; Animals; Brazil; Characidae; Cytosol; Fish Diseases; Glutathione; H | 2013 |
Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α.
Topics: Cell Line, Tumor; Cell Movement; Gene Knockdown Techniques; Glioblastoma; Humans; Hypoxia; Hypoxia-I | 2013 |
Potential use of melatonin supplementation to protect vitrified testicular grafts from hypoxic-ischaemic damage.
Topics: Animals; Culture Media; Hypoxia; In Situ Nick-End Labeling; In Vitro Techniques; Ischemia; Male; Mel | 2014 |
Melatonin attenuates hippocampal neuron apoptosis and oxidative stress during chronic intermittent hypoxia via up-regulating B-cell lymphoma-2 and down-regulating B-cell lymphoma-2-associated X protein.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Apoptosis; bcl-2-Associated X Protein; Down-Regulation; Hipp | 2013 |
Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia.
Topics: Animals; Antioxidants; Aorta, Thoracic; Cell Adhesion Molecules; Chronic Disease; Endothelium, Vascu | 2013 |
Neuroprotective effect of melatonin in experimentally induced hypobaric hypoxia.
Topics: Animals; Brain Edema; Capillaries; Cell Count; Cell Nucleus; Cell Shape; Cognition; Glial Fibrillary | 2013 |
Anticontractile activity of perivascular fat in obese mice and the effect of long-term treatment with melatonin.
Topics: Adiponectin; Adipose Tissue; Animals; Antioxidants; Body Weight; Hypoxia; Inflammation; Male; Melato | 2014 |
Antitumour activity of melatonin in a mouse model of human prostate cancer: relationship with hypoxia signalling.
Topics: Animals; Humans; Hypoxia; Male; Melatonin; Mice; Mice, Nude; Prostatic Neoplasms; Signal Transductio | 2014 |
Melatonin improves cerebrovascular function and decreases oxidative stress in chronically hypoxic lambs.
Topics: Animals; Cerebrovascular Circulation; Hypoxia; Melatonin; Nitric Oxide; Oxidative Stress; Sheep | 2014 |
The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion-induced injury.
Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Brain; Cell Line; Endothelial Cells; G | 2014 |
Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blotting, Western; Cell Proliferation; Hypertension | 2014 |
Melatonin attenuates intermittent hypoxia-induced lipid peroxidation and local inflammation in rat adrenal medulla.
Topics: Adrenal Medulla; Animals; Antioxidants; Cyclooxygenase 2; Hypoxia; Inflammation; Lipid Peroxidation; | 2014 |
Cardioprotective effects of melatonin against myocardial injuries induced by chronic intermittent hypoxia in rats.
Topics: Animals; Antioxidants; Biomarkers; Cardiotonic Agents; Chronic Disease; Cytokines; Gene Expression R | 2015 |
Antioxidants inhibit the inflammatory and apoptotic processes in an intermittent hypoxia model of sleep apnea.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspases; Disease Models, Animal; Hypoxia; Hypoxia | 2015 |
Melatonin modulates the fetal cardiovascular defense response to acute hypoxia.
Topics: Animals; Catecholamines; Female; Fetus; Hypoxia; Melatonin; Nitric Oxide; Oxidative Stress; Pregnanc | 2015 |
Melatonin prevents hyperglycemia in a model of sleep apnea.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Glucose; Body Weight; Cholesterol; Disease Models, Anim | 2015 |
In vitro and in vivo effects of melatonin on sister chromatid exchange in human blood lymphocytes exposed to hypoxia.
Topics: Administration, Oral; Adult; Antimutagenic Agents; Cell Hypoxia; Cells, Cultured; Dose-Response Rela | 2016 |
Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5' adenosine monophosphate-activated protein kinase pathway.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Cardiomegaly; Cardiotonic Agents; Cell Line; Chro | 2015 |
Effects of melatonin on the nitric oxide system and protein nitration in the hypobaric hypoxic rat hippocampus.
Topics: Altitude Sickness; Animals; Antioxidants; Caspase 3; Disease Models, Animal; Hippocampus; Hypoxia; M | 2015 |
[STUDIES OF THE ANTIHYPOXIC AND ANTIAMNESTIC EFFECTS OF MELATONIN IN ANIMALS].
Topics: Amnesia; Animals; Antioxidants; Disease Models, Animal; Hippocampus; Hypoxia; Male; Melatonin; Mice; | 2015 |
Effects of hypoxia and reoxygenation on the antioxidant defense system of the locomotor muscle of the crab Neohelice granulata (Decapoda, Varunidae).
Topics: Animals; Arthropod Proteins; Brachyura; Catalase; Glutamate-Cysteine Ligase; Glutathione; Glutathion | 2016 |
Hypoxia-induced vascular endothelial growth factor secretion by retinal pigment epithelial cells is inhibited by melatonin via decreased accumulation of hypoxia-inducible factors-1α protein.
Topics: Aged; Antioxidants; Cell Survival; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Gene Expressi | 2017 |
A novel combination treatment to stimulate bone healing and regeneration under hypoxic conditions: photobiomodulation and melatonin.
Topics: Alkaline Phosphatase; Animals; Bone Regeneration; Cell Differentiation; Combined Modality Therapy; H | 2017 |
Original research paper. Pulmonary prophylactic impact of melatonin and/or quercetin: A novel therapy for inflammatory hypoxic stress in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrier Proteins; Cytoprotection; Disease Models, Animal; Drug Th | 2017 |
Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia.
Topics: Analysis of Variance; Animals; Blood Glucose; Cricetinae; Glucose Clamp Technique; Hemodynamics; Hyp | 2009 |
Cellular and vascular changes in the retina of neonatal rats after an acute exposure to hypoxia.
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Blotting, Western; Capillary Permeability; Fluor | 2009 |
Hypoxia-induced changes in recovery sleep, core body temperature, urinary 6-sulphatoxymelatonin and free cortisol after a simulated long-duration flight.
Topics: Adult; Aircraft; Altitude; Body Temperature Regulation; Circadian Rhythm; Humans; Hydrocortisone; Hy | 2009 |
Role of glutamate and its receptors and insulin-like growth factors in hypoxia induced periventricular white matter injury.
Topics: Animals; Animals, Newborn; Antioxidants; Brain; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; | 2010 |
The effect of antioxidants (N-acetylcysteine and melatonin) on hypoxia due to carbonmonoxide poisoning.
Topics: Acetylcysteine; Animals; Antioxidants; Brain; Carbon Monoxide Poisoning; Female; Hypoxia; Lung; Mela | 2010 |
Melatonin reduces hippocampal beta-amyloid generation in rats exposed to chronic intermittent hypoxia.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Aspartic | 2010 |
Hypoxia-induced cellular and vascular changes in the nucleus tractus solitarius and ventrolateral medulla.
Topics: Animals; Glutamic Acid; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; Medulla Oblo | 2011 |
Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model.
Topics: Animals; Animals, Newborn; Antioxidants; Cold Temperature; Disease Models, Animal; Drug Evaluation, | 2011 |
Oxidative stress mediates cardiac infarction aggravation induced by intermittent hypoxia.
Topics: Animals; Antioxidants; Arterial Pressure; Cyclic N-Oxides; Ethidium; Hypoxia; Male; Melatonin; Myoca | 2013 |
An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin.
Topics: Analysis of Variance; Animals; Antioxidants; Automatism; Blood-Brain Barrier; Convulsants; Disease M | 2012 |
Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin.
Topics: Altitude; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Epididymis; Hematocrit; Hy | 2011 |
Melatonin protects the heart, lungs and kidneys from oxidative stress under intermittent hypobaric hypoxia in rats.
Topics: Animals; Antioxidants; Epididymis; Heart; Hypoxia; Kidney; Lipid Peroxidation; Liver; Lung; Male; Me | 2012 |
Dietary supplementation of some antioxidants against hypoxia.
Topics: Animals; Antioxidants; Arginine; Chemical and Drug Induced Liver Injury; Cytoprotection; Dietary Sup | 2012 |
Effects of melatonin and epithalamin on the content of protein and lipid peroxidation products in rat cortex and hippocampus under conditions of acute hypoxia.
Topics: Animals; Cerebral Cortex; Free Radicals; Hippocampus; Hypoxia; Lipid Peroxidation; Lipid Peroxides; | 2012 |
Melatonin, melanogenesis, and hypoxic stress in the newt, Triturus carnifex.
Topics: Animals; Dose-Response Relationship, Drug; Hypoxia; Liver; Melanins; Melatonin; Oxygen; Stress, Phys | 2003 |
Effect of melatonin on neurobehavioral dysfunctions induced by intrauterine hypoxia in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Female; Hypoxia; Melatonin; Oxidative Stress; Pheny | 2004 |
Effect of melatonin on biochemical variables induced by phenytoin in organs of mothers, foetuses and offsprings of rats.
Topics: Acetylglucosaminidase; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Female; Glu | 2004 |
Effect of melatonin and stobadine on maternal and embryofoetal toxicity in rats due to intrauterine hypoxia induced by phenytoin administration.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Body | 2004 |
Hypoxic depression of melatonin secretion after simulated long duration flights in man.
Topics: Adult; Altitude; Atmospheric Pressure; Circadian Rhythm; Fatigue; Female; Humans; Hypoxia; Male; Mel | 2004 |
Role of melatonin in carbon monoxide-induced hypoxemia.
Topics: Carbon Monoxide; Cell Survival; Humans; Hypoxia; Melatonin; Reactive Oxygen Species | 2004 |
Melatonin enhances the hypoxic response of rat carotid body chemoreceptor.
Topics: Animals; Calcium; Carotid Body; Chemoreceptor Cells; Circadian Rhythm; Hypoxia; In Vitro Techniques; | 2005 |
Melatonin restores the cytochrome oxidase reactivity in the nodose ganglia of acute hypoxic rats.
Topics: Acute Disease; Animals; Antioxidants; Dose-Response Relationship, Drug; Electron Transport Complex I | 2005 |
Role of melatonin in reducing hypoxia-induced oxidative stress and morphological changes in the liver of male mice.
Topics: Analysis of Variance; Animals; Antioxidants; Hepatocytes; Hypoxia; Lipid Peroxidation; Lipid Peroxid | 2006 |
Effects of melatonin administration on oxidative stress and daily locomotor activity patterns in goldfish.
Topics: Animals; Behavior, Animal; Circadian Rhythm; Goldfish; Hydrogen Peroxide; Hypoxia; Lipid Peroxidatio | 2006 |
Exploiting hypoxia in solid tumors to achieve oncolysis.
Topics: Adenosine Triphosphate; Administration, Oral; Amino Acids; Citrates; Fatty Acids; Humans; Hydrogen-I | 2007 |
Influence of melatonin pretreatment and preconditioning by hypobaric hypoxia on the development of cortical photothrombotic ischemic lesion.
Topics: Animals; Antioxidants; Atmospheric Pressure; Brain Ischemia; Cerebral Cortex; Endothelial Cells; Fre | 2008 |
Effect of melatonin on the relationship between lipid peroxidation and proteolytic activity in basal nuclei of rat brain during acute hypoxia.
Topics: Albumins; Animals; Azo Compounds; Basal Ganglia; Caseins; Collagen; Hypoxia; Lipid Peroxidation; Mal | 2006 |
Increased vascular permeability and nitric oxide production in response to hypoxia in the pineal gland.
Topics: Animals; Base Sequence; Capillary Permeability; DNA Primers; Fluorescent Dyes; Hypoxia; Hypoxia-Indu | 2007 |
Blood-retinal barrier disruption and ultrastructural changes in the hypoxic retina in adult rats: the beneficial effect of melatonin administration.
Topics: Animals; Antioxidants; Aquaporin 4; Astrocytes; Blood-Retinal Barrier; Capillary Permeability; Drug | 2007 |
Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery.
Topics: Animals; Chronic Disease; Disease Models, Animal; Hypertension, Pulmonary; Hypoxia; Male; Melatonin; | 2008 |
Aquaporin 1 - a novel player in spinal cord injury.
Topics: Afferent Pathways; Animals; Antioxidants; Aquaporin 1; Astrocytes; Cell Size; Chronic Disease; Disea | 2008 |
Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia.
Topics: Animals; Hippocampus; Hypoxia; Inflammation Mediators; Male; Melatonin; Neuroprotective Agents; Rats | 2008 |
Melatonin ameliorates hippocampal nitric oxide production and large conductance calcium-activated potassium channel activity in chronic intermittent hypoxia.
Topics: Animals; Hippocampus; Hypoxia; Large-Conductance Calcium-Activated Potassium Channels; Male; Melaton | 2008 |
[Alimentary and oxygen deprivation as the modulator of the bone tissue physiological remodelling rate in young rats].
Topics: Alkaline Phosphatase; Animals; Body Weight; Bone and Bones; Bone Remodeling; Caloric Restriction; El | 2008 |
Melatonin ameliorates calcium homeostasis in myocardial and ischemia-reperfusion injury in chronically hypoxic rats.
Topics: Animals; Antioxidants; Blotting, Western; Calcium; Cardiomegaly; Cells, Cultured; Hematocrit; Homeos | 2008 |
Melatonin is protective in necrotic but not in caspase-dependent, free radical-independent apoptotic neuronal cell death in primary neuronal cultures.
Topics: Animals; Antioxidants; Apoptosis; Aziridines; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cu | 2000 |
Melatonin protects against ischaemic-reperfusion myocardial damage.
Topics: Aniline Compounds; Animals; Calcium; Cells, Cultured; Fluoresceins; Fluorescent Dyes; Heart Ventricl | 2001 |
Effect of melatonin on cyclic nucleotide content and intensity of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypoxia.
Topics: Acute Disease; Animals; Cyclic AMP; Cyclic GMP; Enzyme Activation; Habenula; Heme Oxygenase (Decycli | 2000 |
Hypoxia potentiates exocytosis and Ca2+ channels in PC12 cells via increased amyloid beta peptide formation and reactive oxygen species generation.
Topics: Amyloid beta-Peptides; Animals; Antioxidants; Ascorbic Acid; Cadmium; Calcium Channels; Electrophysi | 2002 |
Melatonin attenuates the neuronal NADPH-d/NOS expression in the nodose ganglion of acute hypoxic rats.
Topics: Animals; Hypoxia; Male; Melatonin; NADPH Dehydrogenase; Neurons; Neuroprotective Agents; Nitric Oxid | 2002 |