melatonin has been researched along with Colitis in 42 studies
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Inducing colitis by dextran sodium sulfate (DSS), HA-MT accumulated in the inflamed colon epithelium of colitis mice, and markedly improved the colitis symptoms, repaired the damaged intestinal barrier and inhibited colon inflammation." | 8.12 | Hyaluronic Acid-Melatonin Nanoparticles Improve the Dysregulated Intestinal Barrier, Microbiome and Immune Response in Mice with Dextran Sodium Sulfate-Induced Colitis. ( Dong, S; Jing, W; Liu, W; Wang, F; Wang, K; Wang, S; Xu, Y; Yang, J; Zhao, X; Zhu, M, 2022) |
| "Melatonin (MLT) was reported to have therapeutic effects on inflammatory bowel disease (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD) due to its anti-inflammatory and immunomodulatory properties." | 8.12 | RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice. ( Deng, Y; Fei, S; Feng, S; Li, L; Mo, Y; Song, J; Wang, K; Wu, J; Xu, Z; Zhang, Q; Zhang, Z; Zhou, R, 2022) |
| "Melatonin supplementation normalized the colitis, oxidative stress, mitochondria dysfunction, apoptosis and inflammation response, including the increase of intestinal permeability, histological score and the level of IL-1β, TNF-α, iNOS, NLRP3, MDA, Bax, Caspase3, Cytochrome C and Caspase9, as well as the reduction of body weight, colon length, Card9, IFN-γ, IL-10, T-AOC, Calpain1, Mfn2, VDAC1, RORα and SIRT1 proteins in DSS-treated mice." | 8.02 | Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/RORα/NF-κB signaling pathways. ( Cao, J; Chen, Y; Dong, Y; Gao, T; Wang, T; Wang, Z, 2021) |
| " Our previous studies found that melatonin exerts an improvement effect in sleep deprivation (SD)- induced corticosterone overproduction and colitis." | 8.02 | Melatonin Ameliorates Corticosterone-Mediated Oxidative Stress-Induced Colitis in Sleep-Deprived Mice Involving Gut Microbiota. ( Cao, J; Chen, Y; Dong, Y; Gao, T; Wang, Z, 2021) |
| "The aim of the present study is to investigate the anti-inflammatory effect of melatonin in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis through the inhibition of Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signalling pathway and activation of melatonin receptor." | 7.91 | Melatonin ameliorates TNBS-induced colitis in rats through the melatonin receptors: involvement of TLR4/MyD88/NF-κB signalling pathway. ( Abdollahi, A; Akbarian, R; Chamanara, M; Dehpour, AR; Mehr, SE; Rashidian, A; Rezayat, SM; Shirkohi, R, 2019) |
| "Using electroanalytical approaches, we investigated how 5-HT release, reuptake and availability as well as melatonin availability are altered in dextran sodium sulfate (DSS)-induced colitis in mice." | 7.88 | Alterations in melatonin and 5-HT signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis. ( Keenan, CM; MacEachern, SJ; Papakonstantinou, E; Patel, BA; Sharkey, KA, 2018) |
| " This study explored the hypothesis that melatonin has beneficial functions in the mouse model of colitis induced by dextran sodium sulfate (DSS), with a specific focus on the expression of intestinal inflammatory cytokines and the serum levels of amino acids." | 7.85 | Melatonin alters amino acid metabolism and inflammatory responses in colitis mice. ( Chen, S; Fang, J; Jiang, Q; Liu, G; Ren, W; Yao, K; Yin, J; Yin, Y, 2017) |
| "The following five groups of C57BL/6 mice were used in this study: (1) group I, control; (2) group II, 2% DSS induced colitis for 7 d; (3) group III, 2% DSS induced colitis and melatonin treatment; (4) group IV, 2% DSS induced colitis with sleep deprivation (SD) using specially designed and modified multiple platform water baths; and (5) group V, 2% DSS induced colitis with SD and melatonin treatment." | 7.83 | Melatonin modulates adiponectin expression on murine colitis with sleep deprivation. ( Baik, HW; Choi, JW; Chung, SH; Gye, MC; Jun, JH; Kim, EK; Kim, JB; Kim, SH; Kim, TK; Lim, JY; Park, YS; Sull, JW; Sung, HJ, 2016) |
| "The aims of the present study were to develop a colon-specific gel formulation of melatonin with sodium alginate and to evaluate its in vitro characteristics and intracolonic performance on oxidative stress parameters, such as nitric oxide (NOx), malondialdehyde (MDA) and glutathione (GSH) levels in rats with acetic acid-induced colitis." | 7.83 | Investigation of the effect of intracolonic melatonin gel formulation on acetic acid-induced colitis. ( Acartürk, F; Bircan, F; Coşkun Cevher, Ş; Esiringü, F; Sarı Kılıçaslan, SM; Tuğcu-Demiröz, F, 2016) |
| " Melatonin is a sleep-related neurohormone, also known to have antioxidant and anti-inflammatory effects in the gastrointestinal tract; however, the effects of melatonin on colitis have been poorly characterized." | 7.81 | Melatonin improves experimental colitis with sleep deprivation. ( Baik, HW; Chung, SH; Kim, DS; Kim, JB; Kim, JH; Kim, TK; Lee, SK; Park, YS, 2015) |
| " Sleep deprivation aggravated, and melatonin attenuated the severity of colitis." | 7.80 | Melatonin attenuates dextran sodium sulfate induced colitis with sleep deprivation: possible mechanism by microarray analysis. ( Ahn, SB; Baik, HW; Chung, SH; Hong, YO; Jo, Y; Jo, YK; Jun, JH; Kim, JH; Kim, OS; Kim, SH; Kim, SS; Park, YS; Shin, JH; Son, BK, 2014) |
| " This study was designed to investigate the effects of melatonin (MEL) and erythropoietin (EPO), which is a known anti-inflammatory and antiapoptotic agent, in dinitrobenzene sulfonic acid (DNBS)-induced colitis in pinealectomized (Px) rats." | 7.79 | Effect of endogen-exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acid-induced colitis. ( Acet, A; Kaya, E; Parlakpinar, H; Tasdemir, S; Vardi, N, 2013) |
| "Melatonin is effective in prevention and short-term treatment of the inflammatory process in acetic-acid induced colitis whereas the benefit of long-term treatment is unclear." | 7.79 | The effect of melatonin on plasma markers of inflammation and on expression of nuclear factor-kappa beta in acetic acid-induced colitis in the rat. ( Blann, A; El Sers, DA; Idriss, NK; Jaumdally, RJ; Sayyed, HG, 2013) |
| "To investigate the effect of melatonin on the colon inflammatory injury of rats with colitis and determine whether this effect is associated with inhibition of chemoattractant molecules interleukin (IL-8) and monocyte chemoattractant protein (MCP-1)." | 7.74 | Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis. ( Li, HX; Li, JH; Liu, K; Wang, L; Zhou, W, 2008) |
| "Rats were randomly assigned to three groups: group I: control, group II: experimental colitis, group III: colitis plus melatonin treatment." | 7.74 | Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats. ( Akcan, A; Akgun, H; Akyildiz, H; Aritas, Y; Esel, D; Kucuk, C; Muhtaroglu, S; Sozuer, E, 2008) |
| "Various evidences have documented that the pineal secretory product melatonin exerts an important anti-inflammatory effect in different experimental models including colitis." | 7.73 | Melatonin modulates signal transduction pathways and apoptosis in experimental colitis. ( Crisafulli, C; Cuzzocrea, S; Di Bella, P; Esposito, E; Mazzon, E; Meli, R; Muià, C; Riccardi, L, 2006) |
| "The aim of this study was to evaluate the effects of melatonin on the inflammatory response and hydroxyproline production in an experimental acute and chronic model of trinitrobenzene sulfonic (TNBS) acid-induced colitis in Wistar rats." | 7.73 | Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis. ( Calvo, JR; la de Lastra, CA; Marquez, E; Motilva, V; Sánchez-Fidalgo, S, 2006) |
| "This study showed that TNBS/ethanol induced colitis was pharmacologically controlled by melatonin in vivo and in vitro." | 7.73 | Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro. ( Hu, XP; Hu, YM; Mei, Q; Xiang, L; Xu, JM; Xu, ZW, 2005) |
| "To investigate the effects of melatonin (MT) on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in rat models of colitis." | 7.72 | Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis. ( Dong, WG; Mei, Q; Xiang, L; Xu, JM; Xu, Y; Yu, JP, 2003) |
| " The aim of this study was to examine the effects of the pineal secretory product melatonin in rats subjected to experimental colitis." | 7.71 | Melatonin reduces dinitrobenzene sulfonic acid-induced colitis. ( Caputi, AP; Ciccolo, A; Cuzzocrea, S; Lepore, V; Mazzon, E; Serraino, I; Terranova, ML, 2001) |
| "Melatonin administration reduces the severity of dextran sodium sulphate (DSS)-induced colitis in mice." | 7.69 | Melatonin reduces the severity of dextran-induced colitis in mice. ( Bubenik, GA; Pentney, PT, 1995) |
| "Melatonin has been studied as a co-adjuvant treatment in several gastrointestinal diseases including irritable bowel syndrome (IBS), constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D), Crohn's disease, ulcerative colitis, and necrotizing enterocolitis." | 6.55 | Melatonin's role as a co-adjuvant treatment in colonic diseases: A review. ( Alatorre-Jiménez, MA; Antoñanzas-Lombarte, Á; Buisac-Ramón, C; Castán-Ruiz, S; Esteban-Zubero, E; García, JJ; López-Pingarrón, L; Ochoa-Moneo, P; Reiter, RJ; Rivas-Jiménez, M; Tan, DX, 2017) |
| "The available ulcerative colitis drugs exhibit limited outcomes and adverse side effects." | 5.72 | Dual role of melatonin as an anti-colitis and anti-extra intestinal alterations against acetic acid-induced colitis model in rats. ( Ahmed, O; Elamir, A; Farid, A, 2022) |
| "Melatonin was demonstrated to improve the oxidative stress resistance of mice with colitis and regulate the intestinal microbial flora, thus improving intestinal health." | 5.48 | Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice. ( Ding, S; Fang, J; Jiang, H; Ma, Y; Zhu, D, 2018) |
| "Colitis was induced by intracolonic (i." | 5.43 | Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats. ( Dong, L; Guo, X; Shang, B; Shi, H; Wang, N; Wang, X; Wang, Y, 2016) |
| "Colitis was induced on day 1 by intracolonic (i." | 5.43 | Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice. ( Fichna, J; Jarmuż, A; Kordek, R; Laudon, M; Sałaga, M; Storr, M; Zielińska, M, 2016) |
| "Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder." | 5.43 | Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016) |
| "Colitis was induced by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS)." | 5.35 | Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis. ( Caminiti, R; Cuzzocrea, S; Esposito, E; Mazzon, E; Meli, R; Riccardi, L, 2008) |
| "Colitis was induced by intracolonic (i." | 5.34 | Protective effect of melatonin in acetic acid induced colitis in rats. ( Cerná, S; Navarová, J; Nosál'ová, V; Zakálová, M; Zeman, M, 2007) |
| "Treatment with melatonin significantly increased GSH levels compared to those in TNBS-treated rats." | 5.33 | The effect of melatonin on TNBS-induced colitis. ( Barbaros, U; Giriş, M; Güloğlu, R; Gündüz, M; Necefli, A; Olgaç, V; Toker, G; Tulumoğlu, B, 2006) |
| "Reduction of epigenetic target, EZH2 by melatonin significantly improves the clinical symptoms of dextran sodium sulphate induced colitis and may be implicated as a potential therapeutic target in IBD management." | 4.12 | Melatonin mediated inhibition of EZH2-NOS2 crosstalk attenuates inflammatory bowel disease in preclinical in vitro and in vivo models. ( Biswal, L; Choudhury, SR; Dev, A; Karmakar, S; Kushwaha, AC; Mohanbhai, SJ; Sardoiwala, MN; Sharma, SS, 2022) |
| "Melatonin (MLT) was reported to have therapeutic effects on inflammatory bowel disease (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD) due to its anti-inflammatory and immunomodulatory properties." | 4.12 | RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice. ( Deng, Y; Fei, S; Feng, S; Li, L; Mo, Y; Song, J; Wang, K; Wu, J; Xu, Z; Zhang, Q; Zhang, Z; Zhou, R, 2022) |
| " Inducing colitis by dextran sodium sulfate (DSS), HA-MT accumulated in the inflamed colon epithelium of colitis mice, and markedly improved the colitis symptoms, repaired the damaged intestinal barrier and inhibited colon inflammation." | 4.12 | Hyaluronic Acid-Melatonin Nanoparticles Improve the Dysregulated Intestinal Barrier, Microbiome and Immune Response in Mice with Dextran Sodium Sulfate-Induced Colitis. ( Dong, S; Jing, W; Liu, W; Wang, F; Wang, K; Wang, S; Xu, Y; Yang, J; Zhao, X; Zhu, M, 2022) |
| "Melatonin supplementation normalized the colitis, oxidative stress, mitochondria dysfunction, apoptosis and inflammation response, including the increase of intestinal permeability, histological score and the level of IL-1β, TNF-α, iNOS, NLRP3, MDA, Bax, Caspase3, Cytochrome C and Caspase9, as well as the reduction of body weight, colon length, Card9, IFN-γ, IL-10, T-AOC, Calpain1, Mfn2, VDAC1, RORα and SIRT1 proteins in DSS-treated mice." | 4.02 | Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/RORα/NF-κB signaling pathways. ( Cao, J; Chen, Y; Dong, Y; Gao, T; Wang, T; Wang, Z, 2021) |
| " Our previous studies found that melatonin exerts an improvement effect in sleep deprivation (SD)- induced corticosterone overproduction and colitis." | 4.02 | Melatonin Ameliorates Corticosterone-Mediated Oxidative Stress-Induced Colitis in Sleep-Deprived Mice Involving Gut Microbiota. ( Cao, J; Chen, Y; Dong, Y; Gao, T; Wang, Z, 2021) |
| "The aim of the present study is to investigate the anti-inflammatory effect of melatonin in trinitrobenzene sulfonic acid (TNBS)-induced rat colitis through the inhibition of Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signalling pathway and activation of melatonin receptor." | 3.91 | Melatonin ameliorates TNBS-induced colitis in rats through the melatonin receptors: involvement of TLR4/MyD88/NF-κB signalling pathway. ( Abdollahi, A; Akbarian, R; Chamanara, M; Dehpour, AR; Mehr, SE; Rashidian, A; Rezayat, SM; Shirkohi, R, 2019) |
| "Using electroanalytical approaches, we investigated how 5-HT release, reuptake and availability as well as melatonin availability are altered in dextran sodium sulfate (DSS)-induced colitis in mice." | 3.88 | Alterations in melatonin and 5-HT signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis. ( Keenan, CM; MacEachern, SJ; Papakonstantinou, E; Patel, BA; Sharkey, KA, 2018) |
| " This study explored the hypothesis that melatonin has beneficial functions in the mouse model of colitis induced by dextran sodium sulfate (DSS), with a specific focus on the expression of intestinal inflammatory cytokines and the serum levels of amino acids." | 3.85 | Melatonin alters amino acid metabolism and inflammatory responses in colitis mice. ( Chen, S; Fang, J; Jiang, Q; Liu, G; Ren, W; Yao, K; Yin, J; Yin, Y, 2017) |
| "The following five groups of C57BL/6 mice were used in this study: (1) group I, control; (2) group II, 2% DSS induced colitis for 7 d; (3) group III, 2% DSS induced colitis and melatonin treatment; (4) group IV, 2% DSS induced colitis with sleep deprivation (SD) using specially designed and modified multiple platform water baths; and (5) group V, 2% DSS induced colitis with SD and melatonin treatment." | 3.83 | Melatonin modulates adiponectin expression on murine colitis with sleep deprivation. ( Baik, HW; Choi, JW; Chung, SH; Gye, MC; Jun, JH; Kim, EK; Kim, JB; Kim, SH; Kim, TK; Lim, JY; Park, YS; Sull, JW; Sung, HJ, 2016) |
| "The aims of the present study were to develop a colon-specific gel formulation of melatonin with sodium alginate and to evaluate its in vitro characteristics and intracolonic performance on oxidative stress parameters, such as nitric oxide (NOx), malondialdehyde (MDA) and glutathione (GSH) levels in rats with acetic acid-induced colitis." | 3.83 | Investigation of the effect of intracolonic melatonin gel formulation on acetic acid-induced colitis. ( Acartürk, F; Bircan, F; Coşkun Cevher, Ş; Esiringü, F; Sarı Kılıçaslan, SM; Tuğcu-Demiröz, F, 2016) |
| " Melatonin is a sleep-related neurohormone, also known to have antioxidant and anti-inflammatory effects in the gastrointestinal tract; however, the effects of melatonin on colitis have been poorly characterized." | 3.81 | Melatonin improves experimental colitis with sleep deprivation. ( Baik, HW; Chung, SH; Kim, DS; Kim, JB; Kim, JH; Kim, TK; Lee, SK; Park, YS, 2015) |
| " Sleep deprivation aggravated, and melatonin attenuated the severity of colitis." | 3.80 | Melatonin attenuates dextran sodium sulfate induced colitis with sleep deprivation: possible mechanism by microarray analysis. ( Ahn, SB; Baik, HW; Chung, SH; Hong, YO; Jo, Y; Jo, YK; Jun, JH; Kim, JH; Kim, OS; Kim, SH; Kim, SS; Park, YS; Shin, JH; Son, BK, 2014) |
| "Melatonin is effective in prevention and short-term treatment of the inflammatory process in acetic-acid induced colitis whereas the benefit of long-term treatment is unclear." | 3.79 | The effect of melatonin on plasma markers of inflammation and on expression of nuclear factor-kappa beta in acetic acid-induced colitis in the rat. ( Blann, A; El Sers, DA; Idriss, NK; Jaumdally, RJ; Sayyed, HG, 2013) |
| " This study was designed to investigate the effects of melatonin (MEL) and erythropoietin (EPO), which is a known anti-inflammatory and antiapoptotic agent, in dinitrobenzene sulfonic acid (DNBS)-induced colitis in pinealectomized (Px) rats." | 3.79 | Effect of endogen-exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acid-induced colitis. ( Acet, A; Kaya, E; Parlakpinar, H; Tasdemir, S; Vardi, N, 2013) |
| "Previous reports suggest that melatonin may play an important role in visceral nociception and neurogenic inflammation." | 3.76 | Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process. ( Mickle, A; Miranda, A; Sengupta, JN; Shahmohammadi, G; Sood, M; Zhang, Z, 2010) |
| "To investigate the effect of melatonin on the colon inflammatory injury of rats with colitis and determine whether this effect is associated with inhibition of chemoattractant molecules interleukin (IL-8) and monocyte chemoattractant protein (MCP-1)." | 3.74 | Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis. ( Li, HX; Li, JH; Liu, K; Wang, L; Zhou, W, 2008) |
| "Rats were randomly assigned to three groups: group I: control, group II: experimental colitis, group III: colitis plus melatonin treatment." | 3.74 | Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats. ( Akcan, A; Akgun, H; Akyildiz, H; Aritas, Y; Esel, D; Kucuk, C; Muhtaroglu, S; Sozuer, E, 2008) |
| "All inflammation parameters were increased by acetic acid-induced colitis or ethanol-induced gastric ulcer compared with the control group." | 3.73 | Exposure to continuous darkness ameliorates gastric and colonic inflammation in the rat: both receptor and non-receptor-mediated processes. ( Cevík, H; Ercan, F; Erkanli, G; Işman, CA; Yeğen, BC, 2005) |
| "This study showed that TNBS/ethanol induced colitis was pharmacologically controlled by melatonin in vivo and in vitro." | 3.73 | Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro. ( Hu, XP; Hu, YM; Mei, Q; Xiang, L; Xu, JM; Xu, ZW, 2005) |
| "Various evidences have documented that the pineal secretory product melatonin exerts an important anti-inflammatory effect in different experimental models including colitis." | 3.73 | Melatonin modulates signal transduction pathways and apoptosis in experimental colitis. ( Crisafulli, C; Cuzzocrea, S; Di Bella, P; Esposito, E; Mazzon, E; Meli, R; Muià, C; Riccardi, L, 2006) |
| "The aim of this study was to evaluate the effects of melatonin on the inflammatory response and hydroxyproline production in an experimental acute and chronic model of trinitrobenzene sulfonic (TNBS) acid-induced colitis in Wistar rats." | 3.73 | Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis. ( Calvo, JR; la de Lastra, CA; Marquez, E; Motilva, V; Sánchez-Fidalgo, S, 2006) |
| "Melatonin could reduce the colon damage in the colitis rats by regulating macrophage activity." | 3.71 | Melatonin reduces colon immunological injury in rats by regulating activity of macrophages. ( Mei, Q; Wei, W; Xiang, L; Xu, JM; Yu, JP; Yue, L, 2002) |
| " The aim of this study was to examine the effects of the pineal secretory product melatonin in rats subjected to experimental colitis." | 3.71 | Melatonin reduces dinitrobenzene sulfonic acid-induced colitis. ( Caputi, AP; Ciccolo, A; Cuzzocrea, S; Lepore, V; Mazzon, E; Serraino, I; Terranova, ML, 2001) |
| "Melatonin has been studied as a co-adjuvant treatment in several gastrointestinal diseases including irritable bowel syndrome (IBS), constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D), Crohn's disease, ulcerative colitis, and necrotizing enterocolitis." | 2.55 | Melatonin's role as a co-adjuvant treatment in colonic diseases: A review. ( Alatorre-Jiménez, MA; Antoñanzas-Lombarte, Á; Buisac-Ramón, C; Castán-Ruiz, S; Esteban-Zubero, E; García, JJ; López-Pingarrón, L; Ochoa-Moneo, P; Reiter, RJ; Rivas-Jiménez, M; Tan, DX, 2017) |
| "The available ulcerative colitis drugs exhibit limited outcomes and adverse side effects." | 1.72 | Dual role of melatonin as an anti-colitis and anti-extra intestinal alterations against acetic acid-induced colitis model in rats. ( Ahmed, O; Elamir, A; Farid, A, 2022) |
| "Melatonin was demonstrated to improve the oxidative stress resistance of mice with colitis and regulate the intestinal microbial flora, thus improving intestinal health." | 1.48 | Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice. ( Ding, S; Fang, J; Jiang, H; Ma, Y; Zhu, D, 2018) |
| "Colon carcinogenesis is long known to be associated with ulcerative colitis (UC), a chronic gastrointestinal disorder." | 1.43 | Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. ( Jena, GB; Kumar, V; Tikoo, KB; Trivedi, PP, 2016) |
| "Colitis was induced by intracolonic (i." | 1.43 | Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats. ( Dong, L; Guo, X; Shang, B; Shi, H; Wang, N; Wang, X; Wang, Y, 2016) |
| "Colitis was induced on day 1 by intracolonic (i." | 1.43 | Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice. ( Fichna, J; Jarmuż, A; Kordek, R; Laudon, M; Sałaga, M; Storr, M; Zielińska, M, 2016) |
| "Colitis was induced by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS)." | 1.35 | Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis. ( Caminiti, R; Cuzzocrea, S; Esposito, E; Mazzon, E; Meli, R; Riccardi, L, 2008) |
| "Colitis was induced by intracolonic (i." | 1.34 | Protective effect of melatonin in acetic acid induced colitis in rats. ( Cerná, S; Navarová, J; Nosál'ová, V; Zakálová, M; Zeman, M, 2007) |
| "Treatment with melatonin significantly increased GSH levels compared to those in TNBS-treated rats." | 1.33 | The effect of melatonin on TNBS-induced colitis. ( Barbaros, U; Giriş, M; Güloğlu, R; Gündüz, M; Necefli, A; Olgaç, V; Toker, G; Tulumoğlu, B, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.38) | 18.2507 |
| 2000's | 14 (33.33) | 29.6817 |
| 2010's | 18 (42.86) | 24.3611 |
| 2020's | 9 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, T | 3 |
| Wang, Z | 3 |
| Dong, Y | 3 |
| Cao, J | 3 |
| Chen, Y | 3 |
| Jing, W | 1 |
| Zhu, M | 1 |
| Wang, F | 1 |
| Zhao, X | 1 |
| Dong, S | 1 |
| Xu, Y | 2 |
| Wang, S | 1 |
| Yang, J | 1 |
| Wang, K | 2 |
| Liu, W | 1 |
| Ahmed, O | 1 |
| Farid, A | 1 |
| Elamir, A | 1 |
| Sardoiwala, MN | 1 |
| Mohanbhai, SJ | 1 |
| Kushwaha, AC | 1 |
| Dev, A | 1 |
| Biswal, L | 1 |
| Sharma, SS | 1 |
| Choudhury, SR | 1 |
| Karmakar, S | 1 |
| Kang, C | 1 |
| Jeong, S | 1 |
| Kim, J | 1 |
| Ju, S | 1 |
| Im, E | 1 |
| Heo, G | 1 |
| Park, S | 1 |
| Yoo, JW | 1 |
| Lee, J | 1 |
| Yoon, IS | 1 |
| Jung, Y | 1 |
| Feng, S | 1 |
| Xu, Z | 1 |
| Zhang, Z | 2 |
| Mo, Y | 1 |
| Deng, Y | 1 |
| Li, L | 1 |
| Fei, S | 1 |
| Wu, J | 1 |
| Zhang, Q | 1 |
| Song, J | 1 |
| Zhou, R | 1 |
| Seoane-Viaño, I | 1 |
| Gómez-Lado, N | 1 |
| Lázare-Iglesias, H | 1 |
| Rey-Bretal, D | 1 |
| Lamela-Gómez, I | 1 |
| Otero-Espinar, FJ | 1 |
| Blanco-Méndez, J | 1 |
| Antúnez-López, JR | 1 |
| Pombo-Pasín, M | 1 |
| Aguiar, P | 1 |
| Ruibal, Á | 1 |
| Luzardo-Álvarez, A | 1 |
| Fernández-Ferreiro, A | 1 |
| Wang, T | 1 |
| Novais, AA | 1 |
| Chuffa, LGA | 1 |
| Zuccari, DAPC | 1 |
| Reiter, RJ | 2 |
| Liu, G | 1 |
| Jiang, Q | 1 |
| Chen, S | 1 |
| Fang, J | 2 |
| Ren, W | 1 |
| Yin, J | 1 |
| Yao, K | 1 |
| Yin, Y | 1 |
| MacEachern, SJ | 1 |
| Keenan, CM | 1 |
| Papakonstantinou, E | 1 |
| Sharkey, KA | 1 |
| Patel, BA | 1 |
| Zhu, D | 1 |
| Ma, Y | 1 |
| Ding, S | 1 |
| Jiang, H | 1 |
| Chamanara, M | 1 |
| Rashidian, A | 1 |
| Mehr, SE | 1 |
| Dehpour, AR | 1 |
| Shirkohi, R | 1 |
| Akbarian, R | 1 |
| Abdollahi, A | 1 |
| Rezayat, SM | 1 |
| Liu, XW | 1 |
| Wang, CD | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain[NCT01269671] | Phase 1 | 0 participants (Actual) | Interventional | 2011-01-31 | Withdrawn (stopped due to PI has left institution) | ||
| Melatonin and Ulcerative Colitis: A Pilot Clinical Trial[NCT00790478] | Phase 2 | 3 participants (Actual) | Interventional | 2009-01-31 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for melatonin and Colitis
| Article | Year |
|---|---|
Exosomes and Melatonin: Where Their Destinies Intersect.
Topics: Animals; Brain Diseases; Colitis; Exosomes; Humans; Kidney Diseases; Liver Diseases; Melatonin; Neop | 2021 |
Melatonin's role as a co-adjuvant treatment in colonic diseases: A review.
Topics: Animals; Cell Proliferation; Colitis; Colitis, Ulcerative; Colonic Diseases; Enterocolitis, Necrotiz | 2017 |
40 other studies available for melatonin and Colitis
| Article | Year |
|---|---|
Melatonin-Mediated Colonic Microbiota Metabolite Butyrate Prevents Acute Sleep Deprivation-Induced Colitis in Mice.
Topics: Animals; Antioxidants; Butyrates; Colitis; Colon; Fecal Microbiota Transplantation; Male; Melatonin; | 2021 |
Hyaluronic Acid-Melatonin Nanoparticles Improve the Dysregulated Intestinal Barrier, Microbiome and Immune Response in Mice with Dextran Sodium Sulfate-Induced Colitis.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Hyalu | 2022 |
Dual role of melatonin as an anti-colitis and anti-extra intestinal alterations against acetic acid-induced colitis model in rats.
Topics: Acetic Acid; Animals; Antioxidants; Colitis; Colitis, Ulcerative; Colon; Glutathione; Melatonin; Rat | 2022 |
Melatonin mediated inhibition of EZH2-NOS2 crosstalk attenuates inflammatory bowel disease in preclinical in vitro and in vivo models.
Topics: Animals; Colitis; Dextran Sulfate; Dextrans; Disease Models, Animal; Enhancer of Zeste Homolog 2 Pro | 2022 |
N-Acetylserotonin is an oxidation-responsive activator of Nrf2 ameliorating colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Heme Oxygenase-1; Melatonin; NF-E2-Related Factor 2; Rat | 2023 |
RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice.
Topics: Animals; Bone Marrow; Colitis; Colon; Cytokines; Dendritic Cells; Dextran Sulfate; Disease Models, A | 2022 |
Evaluation of the therapeutic activity of melatonin and resveratrol in Inflammatory Bowel Disease: A longitudinal PET/CT study in an animal model.
Topics: Animals; Antioxidants; Colitis; Colon; Melatonin; Positron Emission Tomography Computed Tomography; | 2019 |
Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/RORα/NF-κB signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Colitis; Dextran Sulfate; Epithelial Cells; Hydr | 2021 |
Melatonin Ameliorates Corticosterone-Mediated Oxidative Stress-Induced Colitis in Sleep-Deprived Mice Involving Gut Microbiota.
Topics: Animals; Antioxidants; Colitis; Corticosterone; Disease Models, Animal; Gastrointestinal Microbiome; | 2021 |
Melatonin alters amino acid metabolism and inflammatory responses in colitis mice.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Body Weight; Colitis; Dextran Sulfate; Disease Model | 2017 |
Alterations in melatonin and 5-HT signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis.
Topics: Administration, Oral; Administration, Rectal; Animals; Colitis; Colon; Deoxycholic Acid; Dextran Sul | 2018 |
Effects of Melatonin on Intestinal Microbiota and Oxidative Stress in Colitis Mice.
Topics: Animals; Bacteroidetes; Colitis; Disease Models, Animal; Firmicutes; Gastrointestinal Microbiome; Hu | 2018 |
Melatonin ameliorates TNBS-induced colitis in rats through the melatonin receptors: involvement of TLR4/MyD88/NF-κB signalling pathway.
Topics: Animals; Colitis; Colon; Down-Regulation; Intestinal Mucosa; Male; Melatonin; Myeloid Differentiatio | 2019 |
Melatonin alleviates circadian rhythm disruption exacerbating DSS-induced colitis by inhibiting the distribution of HMGB1 in intestinal tissues.
Topics: Animals; Circadian Rhythm; Colitis; Colon; Dextran Sulfate; HMGB1 Protein; Intestinal Mucosa; Male; | 2019 |
The effect of melatonin on plasma markers of inflammation and on expression of nuclear factor-kappa beta in acetic acid-induced colitis in the rat.
Topics: Acetic Acid; Animals; Biomarkers; Colitis; Gene Expression Regulation; Inflammation; Male; Melatonin | 2013 |
Melatonin attenuates dextran sodium sulfate induced colitis with sleep deprivation: possible mechanism by microarray analysis.
Topics: Animals; Body Weight; Colitis; Colon; Dextran Sulfate; DNA; Gene Expression Regulation; Melatonin; M | 2014 |
Investigation of the effect of intracolonic melatonin gel formulation on acetic acid-induced colitis.
Topics: Acetic Acid; Animals; Colitis; Drug Compounding; Gels; Glutathione; Malondialdehyde; Melatonin; Nitr | 2016 |
Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Autophagy; Carcinogenesis; Carcinogens; Col | 2016 |
Melatonin improves experimental colitis with sleep deprivation.
Topics: Animals; Body Weight; Colitis; Cytokines; Disease Models, Animal; Gene Expression Profiling; Inflamm | 2015 |
Protective effect of melatonin on myenteric neuron damage in experimental colitis in rats.
Topics: Animals; Colitis; Colon; Dinitrofluorobenzene; Disease Models, Animal; Heme Oxygenase-1; Inflammatio | 2016 |
Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Indoles; Male; Melatonin; Mice, Inbred BALB C; Pe | 2016 |
Melatonin Treatment Improves Mesenchymal Stem Cells Therapy by Preserving Stemness during Long-term In Vitro Expansion.
Topics: Animals; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cell Transplantation; Ce | 2016 |
Melatonin modulates adiponectin expression on murine colitis with sleep deprivation.
Topics: Adiponectin; Animals; Antibodies; Body Weight; Colitis; Cytokines; Enzyme-Linked Immunosorbent Assay | 2016 |
Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Chemokines; Colitis; Disease Models, Animal; Female; Male; Melatonin; Rats; Trinitrobenzene | 2008 |
Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process.
Topics: Analgesics; Animals; Colitis; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Melatonin; N | 2010 |
Effect of endogen-exogenous melatonin and erythropoietin on dinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Benzenesulfonates; Caspase 3; CD4-Positive T-Lymphocytes; Colitis | 2013 |
Melatonin reduces colon immunological injury in rats by regulating activity of macrophages.
Topics: Animals; Colitis; Colon; Ethanol; Interleukin-1; Intestinal Mucosa; Macrophages; Male; Melatonin; Ni | 2002 |
Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis.
Topics: Animals; Colitis; Colon; Cyclooxygenase 2; Enzyme Inhibitors; Intestinal Mucosa; Isoenzymes; Melaton | 2003 |
Exposure to continuous darkness ameliorates gastric and colonic inflammation in the rat: both receptor and non-receptor-mediated processes.
Topics: Acetic Acid; Animals; Colitis; Darkness; Ethanol; Female; Gastric Mucosa; Inflammation; Intestinal M | 2005 |
Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro.
Topics: Animals; Colitis; Free Radical Scavengers; Hydroxyl Radical; In Vitro Techniques; Male; Malondialdeh | 2005 |
Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Drug Administration Schedule; Intestinal Mucosa; Ma | 2006 |
The effect of melatonin on TNBS-induced colitis.
Topics: Analysis of Variance; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Colitis; Colon; Glutath | 2006 |
Melatonin modulates signal transduction pathways and apoptosis in experimental colitis.
Topics: Animals; Apoptosis; Colitis; Cytokines; Dinitrofluorobenzene; Disease Models, Animal; JNK Mitogen-Ac | 2006 |
Protective effect of melatonin in acetic acid induced colitis in rats.
Topics: Acetic Acid; Animals; Colitis; Colon; Glutathione; Male; Melatonin; Peroxidase; Rats; Rats, Wistar | 2007 |
Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats.
Topics: Animals; Apoptosis; Bacterial Translocation; Caspase 3; Colitis; Colon; Endotoxins; Humans; Male; Me | 2008 |
Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis.
Topics: Animals; Antioxidants; Blotting, Western; Colitis; Dinitrofluorobenzene; Lipid Peroxidation; Male; M | 2008 |
Melatonin reduces the severity of dextran-induced colitis in mice.
Topics: Animals; Colitis; Dextran Sulfate; Female; Intestinal Mucosa; Male; Melatonin; Mice; Serotonin Antag | 1995 |
[Apudocytes and mast cells in chronic inflammation of colon: clinicomorphological correlations].
Topics: Adolescent; Adult; APUD Cells; Biopsy; Colitis; Crohn Disease; Humans; Intestinal Mucosa; Mast Cells | 2000 |
[Melatonin and serotonin in inflammatory colon diseases and colorectal neoplasms].
Topics: Adenocarcinoma; Adolescent; Adult; Aged; APUD Cells; Biomarkers, Tumor; Biopsy; Colitis; Colorectal | 2000 |
Melatonin reduces dinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Colitis; Colon; Dinitrofluorobenzene; Fluorescent Antibody Technique, Indirect; Free Radica | 2001 |