melatonin has been researched along with Aging in 822 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aging and advanced cancer are characterized by similar neuroendocrine and immune deficiencies; the most important of them consist of diminished nocturnal production of the pineal hormone melatonin (MLT) and decreased production of IL-2." | 9.16 | Cancer as the main aging factor for humans: the fundamental role of 5-methoxy-tryptamine in reversal of cancer-induced aging processes in metabolic and immune reactions by non-melatonin pineal hormones. ( Lissoni, P; Messina, G; Rovelli, F, 2012) |
| "One of the host risk factors involved in aging-related diseases is coupled with the reduction of endogenous melatonin (MLT) synthesis in the pineal gland." | 9.12 | Melatonin as a promising modulator of aging related neurodegenerative disorders: Role of microRNAs. ( Alamdari, AF; Kashani, HRK; Rahnemayan, S; Rajabi, H; Rezabakhsh, A; Sanaie, S; Vahed, N, 2021) |
| "The aim of this review is to summarize current studies on the relationship between melatonin and aging." | 9.05 | Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly? ( Akbulut, KG; Güney, Ş; Öztürk, G, 2020) |
| "Aging and various age-related diseases are associated with reductions in melatonin secretion, proinflammatory changes in the immune system, a deteriorating circadian system, and reductions in sirtuin-1 (SIRT1) activity." | 9.01 | Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. ( Hardeland, R, 2019) |
| "Melatonin, along with its metabolites, have long been known to significantly reduce the oxidative stress burden of aging cells or cells exposed to toxins." | 8.98 | Mitochondria: Central Organelles for Melatonin's Antioxidant and Anti-Aging Actions. ( Galano, A; Reiter, RJ; Rosales-Corral, S; Tan, DX; Xu, B; Zhou, XJ, 2018) |
| "From the perspective of systems biology, melatonin is relevant to aging in multiple ways." | 8.91 | Melatonin and circadian oscillators in aging--a dynamic approach to the multiply connected players. ( Hardeland, R, 2015) |
| "Melatonin is known to possess several properties of value for healthy aging, as a direct and indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic agent, enhancer of circadian amplitudes, immune modulator and neuroprotectant." | 8.91 | Melatonin and brain inflammaging. ( Brown, GM; Cardinali, DP; Hardeland, R; Pandi-Perumal, SR, 2015) |
| " Similarly, alterations in circadian rhythms as well as production of the pineal hormone melatonin have been linked to aging and cancer risk." | 8.86 | Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. ( Ahmad, N; Jung-Hynes, B; Reiter, RJ, 2010) |
| " Melatonin, the hormone of the pineal gland, received recently a great deal of attention because of its suggested role in aging processes and availability as over-the-counter drug or food supplement in some countries, including Poland." | 8.84 | Does melatonin play a role in aging processes? ( Karasek, M, 2007) |
| "The endocrine system of aging males reveals changes of more or less unknown significance for estrogens, dehydroepiandrosterone (DHEA), melatonin and growth hormone." | 8.82 | [Hormone therapy in the aging male. Estrogen, DHEA, melatonin, somatotropin]. ( Kliesch, S, 2004) |
| "Although many theories relating the pineal secretory product melatonin to aging have been put forward, the role of this agent in the aging process is not clear." | 8.81 | Melatonin and aging. ( Karasek, M; Reiter, RJ, 2002) |
| " In particular, it quenches what is generally considered the most toxic and damaging free radical produced in the organism, the hydroxyl radical (." | 8.79 | Pineal function during aging: attenuation of the melatonin rhythm and its neurobiological consequences. ( Reiter, RJ, 1994) |
| "It has been proposed that aging occurs because of a failure of the pineal gland to produce melatonin from serotonin each day beginning at sunset and throughout the night." | 8.78 | The role of melatonin and serotonin in aging: update. ( Grad, BR; Rozencwaig, R, 1993) |
| "In photoperiod-sensitive wild animals, the secretion of melatonin (MT) is modulated by external photoperiod, and MT affects inflammation and the ageing process." | 8.31 | Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus). ( Gao, WT; Liu, JX; Sun, HJ; Wang, DH; Zhang, XY, 2023) |
| " Prolonged supplementation with both melatonin and SkQ1 (separately) suppressed the progression of the AMD-like pathology in OXYS rats without affecting the glutamate/GABA system but worsened the condition of the Wistar rat's retina during normal aging." | 8.12 | The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1. ( Antonenko, AK; Fursova, AZ; Kolosova, NG; Telegina, DV, 2022) |
| "Studies have shown that melatonin (MLT) can delay ovarian aging, but the mechanism has not been fully elucidated." | 8.02 | Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve. ( Chen, Y; Fang, F; He, C; Li, X; Liu, G; Liu, Q; Ran, Z; Wang, X; Xiong, J; Yang, C; Yang, L, 2021) |
| "Melatonin (MT) and sirtuins (SIRT) are geroprotective molecules that hold back the aging process and the development of age-related diseases, including cardiovascular pathologies." | 7.96 | Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies. ( Carbone, A; Gadzhiev, A; Hashimova, U; Krylova, TKJ; Kvetnoy, I; Linkova, N; Mazzoccoli, G; Mironova, E; Polyakova, V; Safikhanova, K; Tarquini, R, 2020) |
| "To investigate the role of NLRP3 inflammasome in muscular aging, we evaluated here the morphological and functional markers of sarcopenia in the NLRP3-knockout mice, as well as the beneficial effect of melatonin supplementation." | 7.91 | Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin. ( Acuña-Castroviejo, D; Alsaadawy, RM; Aranda-Martínez, P; Diaz-Casado, ME; Escames, G; Fernández-Martínez, J; Fernández-Ortiz, M; Guerra-Librero, A; López, LC; Sayed, RKA, 2019) |
| " Melatonin, a hormone mainly secreted by the pineal gland, is another anti-aging agent associated with the SIRT1-FOXOs pathway." | 7.88 | Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. ( Govitrapong, P; Jenwitheesuk, A; Mukda, S; Park, S; Shimokawa, I; Tocharus, J; Wongchitrat, P, 2018) |
| "To gain insight into the mechanism of sarcopenia and the protective effect of melatonin, the gastrocnemius muscles of young (3-4 months), early-aged (12 months), and old-aged (24 months) wild-type C57BL/6J female mice were examined by magnetic resonance and microscopy." | 7.88 | The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes. ( Acuña-Castroviejo, D; Diaz-Casado, ME; Escames, G; Fernández-Ortiz, M; López, LC; Mokhtar, DM; Rahim, I; Rusanova, I; Sayed, RKA, 2018) |
| "The present study investigated the anti-aging effects of melatonin on the myocardial mitochondria of D-galactose-aged rats and associated mechanisms." | 7.85 | Anti‑aging effects of melatonin on the myocardial mitochondria of rats and associated mechanisms. ( Guo, XH; Li, YH; Zhai, YZ; Zhang, LC; Zhao, YS, 2017) |
| "Circadian disruptions can contribute to accelerated aging, and the circadian system regulates cognitive and physical functions; therefore, circadian markers (eg, melatonin) may be associated with key aspects of healthy aging and longevity." | 7.83 | Association of urinary melatonin levels and aging-related outcomes in older men. ( Ancoli-Israel, S; Barrett-Connor, E; Cawthon, PM; Devore, EE; Ensrud, K; Harrison, SL; Holton, KF; Orwoll, E; Redline, S; Schernhammer, ES; Stone, KL; Yaffe, K, 2016) |
| " In this study, we examined the underlying neuroprotective mechanism of melatonin against D-galactose-induced memory and synaptic dysfunction, elevated reactive oxygen species (ROS), neuroinflammation and neurodegeneration." | 7.81 | Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model. ( Ali, T; Badshah, H; Kim, MO; Kim, TH, 2015) |
| "This study aimed to investigate the potential protective effects of melatonin (Mel) against aluminium-induced neurodegenerative changes in aging Wistar rats (24-28months old)." | 7.80 | Effects of melatonin on aluminium-induced neurobehavioral and neurochemical changes in aging rats. ( Allagui, MS; Badraoui, R; Bouoni, Z; Elfeki, A; Feriani, A; Murat, JC; Nciri, R; Saoudi, M, 2014) |
| " Moreover, the aging process is also associated with obesity and reduction in melatonin synthesis from the pineal gland and other organs." | 7.79 | Melatonin improves insulin sensitivity independently of weight loss in old obese rats. ( Bacurau, RF; Bordin, S; Camporez, JP; Caperuto, LC; Carpinelli, AR; Carvalho, CR; Cipolla-Neto, J; do Amaral, FG; Hirata, E; Marçal, AC; Peliciari-Garcia, RA; Ribeiro, LM; Siqueira-Filho, MA; Zanuto, R, 2013) |
| "Decline with age of the content of melatonin is considered as one of the leading mechanisms of aging and development of associated diseases, including age-related macular degeneration (AMD)--the disease, which becomes the most common cause of blindness and acuity of vision deterioration in elderly." | 7.79 | [Potential of melatonin for prevention of age-related macular degeneration: experimental study]. ( Fursova, AZh; Kolosova, NG; Stefanova, NA; Zhdankina, AA, 2013) |
| "The aim of the present study was to investigate the effect of aging on several parameters related to glucose homeostasis and insulin resistance in pancreas and how melatonin administration could affect these parameters." | 7.79 | Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8). ( Cuesta, S; García, C; Kireev, R; Rancan, L; Tresguerres, JA; Vara, E, 2013) |
| "We have investigated the effect of melatonin administration on the cytometric and endocrine functions of the ovary during aging." | 7.79 | Ovarian aging: melatonin regulation of the cytometric and endocrine evolutive pattern. ( Díaz, B; Díaz, E; Fernández, BE; Fernández, C; Núñez, P, 2013) |
| "This study investigated the effect of aging-related parameters such as inflammation, oxidative stress and cell death in the heart in an animal model of accelerated senescence and analyzed the effects of chronic administration of melatonin on these markers." | 7.76 | Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging. ( Acuña-Castroviejo, D; Cuesta, S; Forman, K; García, C; Kireev, R; Tresguerres, JA; Vara, E, 2010) |
| " The time-keeping hormone melatonin, an important chemical player in this system, is suspected to have an anti-aging role." | 7.75 | The timing of the shrew: continuous melatonin treatment maintains youthful rhythmic activity in aging Crocidura russula. ( Attia, J; Boeuf, G; Falcon, J; Fons, R; Magnanou, E, 2009) |
| "The level of 6-oxymelatonin sulfate, the main metabolite of melatonin (MT), in morning urine samples from patients with metabolic syndrome (MS) suggests enhanced MT production at night." | 7.75 | [The role of melatonin in the development of metabolic syndrome]. ( Balliuzek, MF; Grinenko, TN; Kvetnaia, TV, 2009) |
| " The purpose of this study was to investigate melatonin levels in age-related macular degeneration (AMD) patients by measurement of 6-sulfatoxymelatonin levels (aMT6s), the major metabolite of melatonin in urine, and compare it with a group of age- and gender-matched controls." | 7.75 | Urinary 6-sulfatoxymelatonin level in age-related macular degeneration patients. ( Chen, M; Hu, DN; McCormick, SA; Perez, V; Rosen, R; Tai, K; Tone, P; Walsh, J; Yu, GP, 2009) |
| "In order to define the functional morphology of the pineal gland (epiphysis) and to reveal extrapineal sources of melatonin (MT) during human aging, biopsy samples obtained from 175 male persons aged 16 to 84 were examined." | 7.74 | [Pineal gland and extrapineal melatonin in visceral organs during natural human aging]. ( Kniaz'kin, IV, 2008) |
| " Since there is evidence that the endothelial dysfunction associated with aging may be partly related to the local formation of reactive oxygen species, the purpose of this study was to examine the effect of the natural antioxidant melatonin (10(-5)mol/l) on in vitro contractility of aged aortic rings under conditions of increased oxidative stress (40 m mol/l glucose concentration in medium)." | 7.74 | Effect of melatonin on vascular responses in aortic rings of aging rats. ( Cardinali, DP; Linares, LM; Obaya-Naredo, D; Pinto, JE; Planells, FM; Reyes-Toso, CF; Ricci, CR, 2007) |
| "This study compared the effects of melatonin supplementation on markers of oxidative stress, and on the activity and expression of antioxidant enzymes in the liver of young (3-month-old) and aging (24-month-old) rats." | 7.74 | Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats. ( Barrio, JP; García-Mediavilla, MV; González, P; González-Gallego, J; Mauriz, JL; Molpeceres, V, 2007) |
| " Here we investigated the association between changes in bladder neuromuscular function and oxidative stress in aging and the possible benefits of melatonin treatment." | 7.74 | Aging impairs neurogenic contraction in guinea pig urinary bladder: role of oxidative stress and melatonin. ( Camello, PJ; Gómez-Pinilla, PJ; Pozo, MJ, 2007) |
| "We examined the effect of daily melatonin supplementation on liver apoptosis induced by aging in rats." | 7.74 | Melatonin is able to reduce the apoptotic liver changes induced by aging via inhibition of the intrinsic pathway of apoptosis. ( Barrio, JP; García-Mediavilla, MV; González, P; González-Gallego, J; Mauriz, JL; Molpeceres, V, 2007) |
| "Both plasma melatonin levels and hypothalamic arcuate nucleus pro-opiomelanocortin (POMC) (biosynthetic precursor to the endogenous opioid ss-endorphin and other opiomelanocortins) mRNA content decrease with aging." | 7.72 | Suppression of hypothalamic pro-opiomelanocortin (POMC) gene expression by daily melatonin supplementation in aging rats. ( Boldt, BM; Marck, BT; Matsumoto, AM; Rasmussen, DD; Yellon, SM, 2003) |
| "Melatonin secretion is an endogenous synchronizer, and it may possess some anti-aging properties." | 7.72 | Qualitative and quantitative changes of melatonin levels in physiological and pathological aging and in centenarians. ( Cinchetti, W; Cravello, L; Ferrari, E; Fioravanti, M; Guazzoni, V; Magri, F; Sarra, S, 2004) |
| "The present study tested the hypothesis that responsiveness to melatonin, the presence of the melatonin rhythm in circulation, and parameters of the GnRH neuron system are sustained across the aging continuum in Siberian hamsters." | 7.71 | Aging, reproduction, and the melatonin rhythm in the Siberian hamster. ( Horton, TH; Yellon, SM, 2001) |
| "It is generally accepted that antioxidant properties of melatonin significantly contribute to its antiaging effect." | 7.71 | Antioxidant and antiaging activity of N-acetylserotonin and melatonin in the in vivo models. ( Bachurin, S; Oxenkrug, G; Requintina, P, 2001) |
| "Pineal melatonin secretion has been reported to commonly decrease with aging, whereas intra-abdominal adiposity, plasma insulin and plasma leptin levels tend to increase." | 7.71 | Aging-dependent changes in the effect of daily melatonin supplementation on rat metabolic and behavioral responses. ( Larsen, SA; Mitton, DR; Rasmussen, DD; Yellon, SM, 2001) |
| " To assess the effect of aging and accelerated aging on the circadian pacemaker of this primate, we measured body weight variations, the daily rhythm in urine 6-sulfatoxymelatonin and the light-induced expression of the immediate early gene (Fos) in the suprachiasmatic nucleus of mouse lemurs that had been exposed to different photoperiodic cycles." | 7.71 | Artificially accelerated aging by shortened photoperiod alters early gene expression (Fos) in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, Microcebus murinus. ( Aujard, F; Claustrat, B; Cooper, HM; Dkhissi-Benyahya, O; Fournier, I; Perret, M; Schilling, A, 2001) |
| "The aim of this study was to determine if long-term treatment with melatonin (MEL), a purported anti-aging agent, was as effective as calorie restriction (CR) in modulating immune parameters in aging Fischer 344 male rats." | 7.71 | Melatonin fails to modulate immune parameters influenced by calorie restriction in aging Fischer 344 rats. ( Evans, TR; Nelson, JF; Pahlavani, MA; Shu, JH; Vargas, DA, 2002) |
| "As previous studies have suggested that melatonin and serotonin may be involved in the regulation of intraocular pressure, retinal concentrations of melatonin, 5-HT, and related indoleamines measured at day and at night were studied during the development of a glaucoma-like disorder with increased intraocular pressure in the al mutant quail." | 7.70 | Day and night dysfunction in intraretinal melatonin and related indoleamines metabolism, correlated with the development of glaucoma-like disorder in an avian model. ( Chanut, E; Dkhissi, O; Nguyen-Legros, J; Repérant, J; Trouvin, JH; Versaux-Botteri, C, 1998) |
| "The effect of aging and melatonin on 24-h rhythms in tyrosine hydroxylase activity and 3H - choline conversion into 3H - acetylcholine were examined in cervical, stellate, coeliac-mesenteric and hypogastric ganglia, and in the adrenal medulla and heart of rats." | 7.70 | Diurnal rhythms in norepinephrine and acetylcholine synthesis of sympathetic ganglia, heart and adrenals of aging rats: effect of melatonin. ( Brusco, LI; Cardinali, DP; Esquifino, AI; García-Bonacho, M, 1998) |
| "Dark-cycle, night administration of the pineal hormone melatonin in drinking water to aging mice (15 months of age) prolongs survival of BALB/c females from 23." | 7.69 | Pineal control of aging: effect of melatonin and pineal grafting on aging mice. ( Pierpaoli, W; Regelson, W, 1994) |
| "Sequential measures of daytime and nighttime sulphatoxy-melatonin (aMT6s) in 10 female patients with anorexia nervosa (AN) and 12 female patients with concurrent AN with bulimic symptoms (AN + BN) were compared with 13 female control subjects." | 7.68 | The acute effects of starvation on 6-sulphatoxy-melatonin output in subgroups of patients with anorexia nervosa. ( Brown, GM; Ford, CG; Kennedy, SH; Ralevski, E, 1993) |
| "Circadian, continued treatment with melatonin during the dark cycle produces changes in the blood level of thyroid hormones in aging mice." | 7.68 | The involvement of pineal gland and melatonin in immunity and aging. I. Thymus-mediated, immunoreconstituting and antiviral activity of thyrotropin-releasing hormone. ( Pierpaoli, W; Yi, C, 1990) |
| "We investigated the age-related changes in the circadian rhythm of plasma melatonin as a potential index of brain aging in man." | 7.67 | Plasma melatonin--an index of brain aging in humans? ( Hariharasubramanian, N; Isaac, I; Nair, NP; Pilapil, C; Thavundayil, JX, 1986) |
| "Melatonin is a tryptophan-derived ancestral molecule evolved in bacteria." | 6.82 | Melatonin-related signaling pathways and their regulatory effects in aging organisms. ( Atayik, MC; Çakatay, U, 2022) |
| "Melatonin is a biological hormone produced by the body that has good free radical scavenging effects, antioxidant effects and other effects." | 6.72 | The role of melatonin in sarcopenia: Advances and application prospects. ( He, M; Hu, P; Jin, H; Li, Y; Tang, K; Wang, X; Wu, Y; Xie, W; Yu, D, 2021) |
| "Melatonin is an ancient molecule that is evident in high concentrations in various tissues throughout the body." | 6.72 | Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders. ( Brown, GM; Gonçalves, VF; Kennedy, JL; Melhuish Beaupre, LM, 2021) |
| "Melatonin has been shown to have the capacity to control eye pigmentation and thereby regulate the amount of light reaching the photoreceptors, to scavenge hydroxyradicals and to protect retinal pigment epithelium (RPE) cells from oxidative damage." | 6.71 | Effects of melatonin in age-related macular degeneration. ( Guo, M; Pan, X; Pierpaoli, W; Yan, H; Yi, C, 2005) |
| "Melatonin also has strong antioxidant activities to scavenge free radicals such as reactive oxygen species (ROS)." | 6.66 | Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging. ( Jozaki, M; Maekawa, R; Mihara, Y; Reiter, RJ; Sato, S; Shinagawa, M; Shirafuta, Y; Sugino, N; Takasaki, A; Taketani, T; Tamura, H; Tamura, I; Tanabe, M, 2020) |
| "Melatonin is a neuroendocrine hormone mainly synthesized in the pineal gland and exhibits a wide range of biological functions, such as sleep control, regulating circadian rhythm, immune enhancement, metabolism regulation, antioxidant, anti-aging, and anti-tumor effects." | 6.66 | Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases. ( Akbar, M; Luo, F; Rungratanawanich, W; Sandhu, AF; Song, BJ; Wang, X; Williams, GE; Zhou, S, 2020) |
| "Colorectal cancer is one of the most common cancers among the elderly, which is also seen in the forms of hereditary syndromes occurring in younger individuals." | 6.66 | Melatonin: An important anticancer agent in colorectal cancer. ( Ghazizadeh, S; Gholamzadeh, S; Majidinia, M; Mihanfar, A; Mirza-Aghazadeh-Attari, M; Mohammadzadeh, A; Mostavafi, S; Sadighparvar, S; Yousefi, B, 2020) |
| "Melatonin is a highly effective and ubiquitously acting antioxidant and free radical scavenger that is normally produced in all organisms." | 6.53 | Melatonin as a Potential Agent in the Treatment of Sarcopenia. ( Boga, JA; Coto-Montes, A; Reiter, RJ; Tan, DX, 2016) |
| "Melatonin is a neurohormone secreted mainly by the pineal gland that controls circadian rhythm, which is primarily regulated by light." | 6.52 | Melatonin in aging women. ( Caglar, GS; Gursoy, AY; Kiseli, M, 2015) |
| "Melatonin is a strong antioxidant (often it is called scavenger of free radicals), which protects the body from the effects of noxious compounds." | 6.47 | Melatonin and aging: prospects for human treatment. ( Bubenik, GA; Konturek, SJ, 2011) |
| "Melatonin has been shown as a specific antioxidant due to its amphiphilic feature that allows it to cross physiological barriers, thereby reducing oxidative damage in both lipid and aqueous cell environments." | 6.46 | Melatonin: action as antioxidant and potential applications in human disease and aging. ( Bonnefont-Rousselot, D; Collin, F, 2010) |
| "Melatonin has the potential therapeutic value to enhance immune function in aged individuals." | 6.44 | Melatonin and the immune system in aging. ( Cardinali, DP; Esquifino, AI; Pandi-Perumal, SR; Srinivasan, V, 2008) |
| "Melatonin has potential utility both in slowing normal brain aging and in treatment of neurodegenerative conditions." | 6.44 | Melatonin and the aging brain. ( Bondy, SC; Sharman, EH, 2007) |
| "Melatonin not only plays an important role in the regulation of circadian rhythms, but also acts as antioxidant and neuroprotector that may be of importance in aging and Alzheimer's disease (AD)." | 6.43 | The human pineal gland and melatonin in aging and Alzheimer's disease. ( Swaab, DF; Wu, YH, 2005) |
| "Melatonin has been shown to be effective in arresting neurodegenerative phenomena seen in experimental models of Alzheimer's disease, Parkinsonism and ischemic stroke." | 6.43 | Role of melatonin in neurodegenerative diseases. ( Cardinali, DP; Esquifino, AI; Hardeland, R; Maestroni, GJ; Pandi-Perumal, SR; Srinivasan, V, 2005) |
| "Melatonin is a prime candidate for slowing the aging process and targeting its underlying pathology." | 6.43 | Melatonin, aging, and age-related diseases: perspectives for prevention, intervention, and therapy. ( Poeggeler, B, 2005) |
| "Melatonin has attained increasing prominence as a candidate for ameliorating these changes occurring during senescence." | 6.42 | Retardation of brain aging by chronic treatment with melatonin. ( Bondy, SC; Campbell, A; Lahiri, DK; Perreau, VM; Sharman, EH; Sharman, KZ; Zhou, J, 2004) |
| "Melatonin potentially plays an important role in aging, prolongation of life span, and health in the aged individual." | 6.42 | Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders. ( Bondy, S; Chen, D; Greig, NH; Lahiri, DK; Lahiri, P; Rogers, JT, 2004) |
| "Melatonin is a hormone produced mainly by the pineal gland and secreted primarily at night, when it reaches levels 10 times higher than those present in the daytime." | 6.41 | Human aging and melatonin. Clinical relevance. ( Touitou, Y, 2001) |
| "Melatonin has a number of properties as a consequence of which it could be beneficial to animals as they age." | 6.41 | Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging. ( El-Sawi, MR; Manchester, LC; Reiter, RJ; Tan, DX, 2002) |
| "Melatonin is a hormone secreted by the pineal gland in response to photoperiods and influences many important biological processes." | 6.40 | Melatonin, immune modulation and aging. ( Ardestani, SK; Elliott, KK; Inserra, PF; Liang, B; Molitor, M; Watson, RR; Zhang, Z, 1997) |
| "Melatonin is an extremely interesting hormone." | 6.39 | Melatonin as an antiaging drug: between facts and fantasy. ( Huether, G, 1996) |
| "Melatonin is a very potent and efficient endogenous radical scavenger." | 6.38 | Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis. ( Chen, LD; Manchester, LC; Poeggeler, B; Reiter, RJ; Tan, DX, 1993) |
| "Melatonin has now been shown to be a potent immunoregulatory agent, and to be able to antagonize the immunosuppressive effects of acute anxiety stress in mice, as measured by antibody production, by thymus weight, and by the capacity of stressed- and evening-melatonin-treated mice to react against a lethal virus." | 6.37 | Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its anti-aging effects. ( Maestroni, GJ; Pierpaoli, W, 1987) |
| " Thus, long-term use of exogenous melatonin led to more stable functioning of the kidneys and water-salt metabolism in old animals compared with the control group." | 5.91 | [Effect of pharmacological stimulation of melatonin receptors on renal function in aging.] ( Goransky, AI; Vinogradova, IA; Zhukova, OV, 2023) |
| "Human skin aging is associated with functional deterioration on multiple levels of physiology, necessitating the development of effective skin senotherapeutics." | 5.91 | Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo. ( Akhundlu, A; Chéret, J; Gherardini, J; Gomez-Gomez, T; Gompels, M; Lee, WW; Linowiecka, K; Lopez de Mendoza, G; Paus, R; Samra, T, 2023) |
| "Melatonin treatment significantly attenuated body weight gain at 23 weeks (control; 57." | 5.62 | Long-term melatonin treatment attenuates body weight gain with aging in female mice. ( Doi-Tanaka, Y; Kawamoto-Jozaki, M; Maekawa, R; Mihara, Y; Sato, S; Shirafuta, Y; Sugino, N; Takagi, H; Taketani, T; Tamura, H; Tamura, I, 2021) |
| "Melatonin (MT) has been demonstrated to impact the cardiovascular system." | 5.56 | Melatonin alleviates vascular calcification and ageing through exosomal miR-204/miR-211 cluster in a paracrine manner. ( Cui, RR; Guo, B; Li, F; Liao, XB; Lin, X; Liu, YS; Shan, SK; Wang, Y; Wu, F; Xu, F; Yuan, LQ; Zheng, MH; Zhong, JY; Zhou, E, 2020) |
| "We found that Huntington's disease mice had increased mtDNA release, cGAS activation, and inflammation, all inhibited by exogenous melatonin." | 5.56 | Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration. ( Baranov, SV; Carlisle, DL; Friedlander, RM; Jauhari, A; Kim, J; Li, F; Minnigh, MB; Oberly, P; Poloyac, SM; Singh, T; Suofu, Y; Wang, X; Yablonska, S, 2020) |
| " Here, we tested the effect of chronic administration of melatonin (MLT) on brain insulin resistance and cognition deficits caused by a high-fat diet (HFD) in aged rats." | 5.51 | Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. ( Chen, M; Deng, Q; Gao, H; Huang, F; Huang, Q; Ma, C; Rong, S; Xu, J; Yang, W; Zhang, L, 2019) |
| "Melatonin has been considered as an effective remedy for circadian rhythm shift." | 5.48 | Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice. ( Chu, S; Cui, Y; Gu, X; Li, X; Ma, Z; Qian, Y; Shao, X; Song, J; Xia, T; Xu, F, 2018) |
| " A histological analysis revealed that chronic intake of MEL diminished the age-dependent changes in the structure of muscle fibers of the left ventricle, muscle fiber swelling, and injury zones characteristic of acute cardiac failure caused by ISO." | 5.48 | Effect of Melatonin on Rat Heart Mitochondria in Acute Heart Failure in Aged Rats. ( Akatov, V; Baburina, Y; Fadeeva, I; Krestinina, O; Kruglov, A; Odinokova, I; Sotnikova, L; Zvyagina, A, 2018) |
| "Melatonin treatment partially restored the rhythms and daily pulse (ratio of maximum:minimum levels) in liver and intestine in 12 months group." | 5.46 | Daily Socs1 rhythms alter with aging differentially in peripheral clocks in male Wistar rats: therapeutic effects of melatonin. ( Jagota, A; Vinod, C, 2017) |
| "Rats treated with melatonin had higher bone volume, bone trabecular number, trabecular thickness, and cortical thickness in comparison to the control group." | 5.40 | Melatonin dietary supplement as an anti-aging therapy for age-related bone loss. ( Barralet, JE; Calvo-Guirado, JL; Eimar, H; Prieto, S; Tamimi, F; Torres, J; Tresguerres, IF; Tresguerres, JA, 2014) |
| "Melatonin treatment of old animals largely prevented the age-associated alterations of mitochondrial bioenergetic parameters." | 5.39 | Decline in cytochrome c oxidase activity in rat-brain mitochondria with aging. Role of peroxidized cardiolipin and beneficial effect of melatonin. ( De Benedictis, V; Paradies, G; Petrosillo, G; Ruggiero, FM, 2013) |
| "Melatonin treatment counteracted both these processes." | 5.36 | Increased susceptibility to Ca(2+)-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: effect of melatonin. ( Moro, N; Paradies, G; Paradies, V; Petrosillo, G; Ruggiero, FM, 2010) |
| "Melatonin treatment did not modify activities of antioxidant enzymes and negligibly modified the level of tocopherol and isoenzyme spectrum of lactate dehydrogenase in rat heart." | 5.36 | Antioxidant system and energy provision of the rat heart during aging depend on illumination regimen and are resistant to exogenous melatonin. ( Anisimov, VN; Ilukha, VA; Ilyina, TN; Khizhkin, EA; Unzhakov, AR; Vinogradova, IA, 2010) |
| "Melatonin treated rats showed a relative increment in the intensity of MAP-2 immuno-staining in both regions after 6 or 12 months of treatment, as compared with age matched control rats." | 5.35 | Melatonin attenuates the decrement of dendritic protein MAP-2 immuno-staining in the hippocampal CA1 and CA3 fields of the aging male rat. ( Cisneros, LO; Gutiérrez-Ospina, G; Jiménez-Trejo, F; Mendoza-Torreblanca, J; Prieto-Gómez, B; Reyes, ME; Reyes-Vázquez, C; Velázquez-Paniagua, M, 2008) |
| "Melatonin is an antioxidant and free radical scavenger." | 5.33 | Potent therapeutic effect of melatonin on aging skin in pinealectomized rats. ( Batçioğlu, K; Eşrefoğlu, M; Gül, M; Parlakpinar, H; Seyhan, M; Uyumlu, B, 2005) |
| "Melatonin treatment resulted in reduced concentrations as compared with those of the control old rats." | 5.31 | Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin. ( Debeljuk, L; Díaz López, B; Díaz Rodríguez, E; Fernández Alvarez, C, 2002) |
| " Chronic administration of melatonin (0." | 5.31 | Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks. ( Kulkarni, SK; Raghavendra, V, 2001) |
| "Both melatonin treatment in old mice and pineal graft into the thymus of old mice correct the reduced thymic endocrine activity and increase the weight of the thymus and its cellularity." | 5.29 | The immuno-reconstituting effect of melatonin or pineal grafting and its relation to zinc pool in aging mice. ( Bulian, D; Fabris, N; Mocchegiani, E; Muzzioli, M; Pierpaoli, W; Santarelli, L; Tibaldi, A, 1994) |
| "Melatonin in tissues was extracted, identified, and determined by gas chromatography-mass spectrometry (GC-MS) and/or radioimmunoassay." | 5.28 | Fluctuation of blood melatonin concentrations with age: result of changes in pineal melatonin secretion, body growth, and aging. ( Brown, GM; Hong, GX; Pang, SF; Tang, PL; Tsang, CW; Yip, PC, 1990) |
| "125I-melatonin was used as a melatonin receptor probe." | 5.27 | Melatonin receptors in discrete brain areas of the male rat. Impact of aging on density and on circadian rhythmicity. ( Laudon, M; Nir, I; Zisapel, N, 1988) |
| "Aging and advanced cancer are characterized by similar neuroendocrine and immune deficiencies; the most important of them consist of diminished nocturnal production of the pineal hormone melatonin (MLT) and decreased production of IL-2." | 5.16 | Cancer as the main aging factor for humans: the fundamental role of 5-methoxy-tryptamine in reversal of cancer-induced aging processes in metabolic and immune reactions by non-melatonin pineal hormones. ( Lissoni, P; Messina, G; Rovelli, F, 2012) |
| "One of the host risk factors involved in aging-related diseases is coupled with the reduction of endogenous melatonin (MLT) synthesis in the pineal gland." | 5.12 | Melatonin as a promising modulator of aging related neurodegenerative disorders: Role of microRNAs. ( Alamdari, AF; Kashani, HRK; Rahnemayan, S; Rajabi, H; Rezabakhsh, A; Sanaie, S; Vahed, N, 2021) |
| "The aim of this review is to summarize current studies on the relationship between melatonin and aging." | 5.05 | Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly? ( Akbulut, KG; Güney, Ş; Öztürk, G, 2020) |
| "Aging and various age-related diseases are associated with reductions in melatonin secretion, proinflammatory changes in the immune system, a deteriorating circadian system, and reductions in sirtuin-1 (SIRT1) activity." | 5.01 | Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. ( Hardeland, R, 2019) |
| "Melatonin research has been experiencing hyper growth in the last two decades; this relates to its numerous physiological functions including anti-inflammation, oncostasis, circadian and endocrine rhythm regulation, and its potent antioxidant activity." | 4.98 | The multiple functions of melatonin in regenerative medicine. ( Darband, SG; Jahanban-Esfahlan, R; Kaviani, M; Majidinia, M; Mohebbi, I; Nabavi, SM; Rastegar, M; Reiter, RJ; Shakouri, SK; Yousefi, B, 2018) |
| " Endogenous secretion of melatonin decreases with aging across genders, and, among women, menopause is associated with a significant reduction of melatonin levels, affecting sleep." | 4.93 | Circadian rhythm and menopause. ( Pines, A, 2016) |
| "Melatonin is known to possess several properties of value for healthy aging, as a direct and indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic agent, enhancer of circadian amplitudes, immune modulator and neuroprotectant." | 4.91 | Melatonin and brain inflammaging. ( Brown, GM; Cardinali, DP; Hardeland, R; Pandi-Perumal, SR, 2015) |
| "The pineal hormone melatonin (MLT) has potent anti-breast cancer activity, its actions are heavily mediated via the MT1 receptor and subsequent modulation of downstream signaling pathways including cAMP/PKA, Erk/MAPK, p38, and Ca2+/calmodulin." | 4.89 | Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth. ( Blask, DE; Cheng, C; Dauchy, B; Hill, SM; Jockers, R; Mao, L; Yuan, L, 2013) |
| "Melatonin, an indolamine derived from the amino-acid tryptophan, participates in diverse physiological functions and has great functional versatility related to the regulation of circadian rhythms and seasonal behaviour, sexual development, retinal physiology, tumour inhibition, as an antioxidant, immunomodulatory and anti-aging properties." | 4.88 | Melatonin, a natural programmed cell death inducer in cancer. ( de la Lastra, CA; Guerrero, JM; Packham, G; Sánchez-Hidalgo, M; Villegas, I, 2012) |
| " We present a brief overview of the biological markers that are used to define differences between CT groups (sleep-wake cycle, body temperature, cortisol and melatonin), and we assess the implications for CT and adjustment to shiftwork and jet lag." | 4.88 | Circadian typology: a comprehensive review. ( Adan, A; Archer, SN; Di Milia, L; Hidalgo, MP; Natale, V; Randler, C, 2012) |
| " Similarly, alterations in circadian rhythms as well as production of the pineal hormone melatonin have been linked to aging and cancer risk." | 4.86 | Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. ( Ahmad, N; Jung-Hynes, B; Reiter, RJ, 2010) |
| " Hormones responsible for some of the manifestations associated with aging are growth hormone, insulin-like growth factor-1 (IGF-1), melatonin, dehydroepiandrosterone (DHEA), sex hormones and thyroid hormones." | 4.85 | [Hormone replacement therapy--growth hormone, melatonin, DHEA and sex hormones]. ( Akishita, M; Fukai, S, 2009) |
| " Melatonin, the hormone of the pineal gland, received recently a great deal of attention because of its suggested role in aging processes and availability as over-the-counter drug or food supplement in some countries, including Poland." | 4.84 | Does melatonin play a role in aging processes? ( Karasek, M, 2007) |
| "To investigate whether free melatonin may be better suited to reveal age-related changes, we studied the circadian rhythm alterations in saliva melatonin levels during aging." | 4.82 | Alterations in the circadian rhythm of salivary melatonin begin during middle-age. ( Hofman, MA; Liu, RY; Swaab, DF; van Heerikhuize, J; Zhou, JN, 2003) |
| "The endocrine system of aging males reveals changes of more or less unknown significance for estrogens, dehydroepiandrosterone (DHEA), melatonin and growth hormone." | 4.82 | [Hormone therapy in the aging male. Estrogen, DHEA, melatonin, somatotropin]. ( Kliesch, S, 2004) |
| "This brief review considers the potential role of melatonin in the processes of aging, the prolongation of life span and health in the aged." | 4.81 | Melatonin, longevity and health in the aged: an assessment. ( Lopez-Burillo, S; Mayo, JC; Reiter, RJ; Sainz, RM; Tan, DX, 2002) |
| "Melatonin might be implicated in menopause-associated processes such as insomnia, breast cancer, and general aging." | 4.80 | "Melatonin replacement therapy" for postmenopausal women: is it justified? ( Brzezinski, A, 1998) |
| " In particular, it quenches what is generally considered the most toxic and damaging free radical produced in the organism, the hydroxyl radical (." | 4.79 | Pineal function during aging: attenuation of the melatonin rhythm and its neurobiological consequences. ( Reiter, RJ, 1994) |
| "Currently available as a dietary supplement, the pineal hormone melatonin is portrayed by the media as a formidable weapon against disease and aging." | 4.79 | Melatonin: media hype or therapeutic breakthrough? ( Kendler, BS, 1997) |
| "It has been proposed that aging occurs because of a failure of the pineal gland to produce melatonin from serotonin each day beginning at sunset and throughout the night." | 4.78 | The role of melatonin and serotonin in aging: update. ( Grad, BR; Rozencwaig, R, 1993) |
| "In photoperiod-sensitive wild animals, the secretion of melatonin (MT) is modulated by external photoperiod, and MT affects inflammation and the ageing process." | 4.31 | Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus). ( Gao, WT; Liu, JX; Sun, HJ; Wang, DH; Zhang, XY, 2023) |
| "The pineal gland is suggested to be an essential area involved in the programming of fertility, growth, aging, and death of mammals via the released hormone melatonin." | 4.12 | Metabolic footprint in young, middle-aged and elderly rats with melatonin deficit. ( Boyadjiev, N; Georgieva, K; Hrischev, P; Ivanova, P; Tchekalarova, J, 2022) |
| " Prolonged supplementation with both melatonin and SkQ1 (separately) suppressed the progression of the AMD-like pathology in OXYS rats without affecting the glutamate/GABA system but worsened the condition of the Wistar rat's retina during normal aging." | 4.12 | The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1. ( Antonenko, AK; Fursova, AZ; Kolosova, NG; Telegina, DV, 2022) |
| "Melatonin (MT) and sirtuins (SIRT) are geroprotective molecules that hold back the aging process and the development of age-related diseases, including cardiovascular pathologies." | 3.96 | Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies. ( Carbone, A; Gadzhiev, A; Hashimova, U; Krylova, TKJ; Kvetnoy, I; Linkova, N; Mazzoccoli, G; Mironova, E; Polyakova, V; Safikhanova, K; Tarquini, R, 2020) |
| "Night work provides biorhythms desynchronization, disorder of melatonin-producing function and accelerated pineal gland aging." | 3.96 | [AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.] ( Ilina, AR; Ivko, OM; Linkova, NS; Ryzhak, GA; Sharova, AA, 2020) |
| "To investigate the role of NLRP3 inflammasome in muscular aging, we evaluated here the morphological and functional markers of sarcopenia in the NLRP3-knockout mice, as well as the beneficial effect of melatonin supplementation." | 3.91 | Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin. ( Acuña-Castroviejo, D; Alsaadawy, RM; Aranda-Martínez, P; Diaz-Casado, ME; Escames, G; Fernández-Martínez, J; Fernández-Ortiz, M; Guerra-Librero, A; López, LC; Sayed, RKA, 2019) |
| " Melatonin, a hormone mainly secreted by the pineal gland, is another anti-aging agent associated with the SIRT1-FOXOs pathway." | 3.88 | Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway. ( Govitrapong, P; Jenwitheesuk, A; Mukda, S; Park, S; Shimokawa, I; Tocharus, J; Wongchitrat, P, 2018) |
| "To gain insight into the mechanism of sarcopenia and the protective effect of melatonin, the gastrocnemius muscles of young (3-4 months), early-aged (12 months), and old-aged (24 months) wild-type C57BL/6J female mice were examined by magnetic resonance and microscopy." | 3.88 | The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes. ( Acuña-Castroviejo, D; Diaz-Casado, ME; Escames, G; Fernández-Ortiz, M; López, LC; Mokhtar, DM; Rahim, I; Rusanova, I; Sayed, RKA, 2018) |
| " Melatonin, a potent free radical scavenger and broad spectrum antioxidant, has been shown to counteract inflammation and apoptosis in brain injury." | 3.88 | Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats. ( Calvo-Soto, M; García, C; González, P; Hyacinthe, B; Paredes, SD; Rancan, L; Rodríguez-Bobada, C; Tresguerres, JAF; Vara, E, 2018) |
| "The absence of light/dark alternation (constant light and constant darkness) affects only those physiological indices that follow the organism's circadian rhythms (Activity of Antioxidant Enzymes (AOE), levels of individual immune system cell types), whereas changes in the parameters not governed by circadian fluctuations (vitamin concentrations, pubescence, and aging) depend on the level of melatonin produced by the pineal gland." | 3.85 | Physiological and Biochemical Mechanisms of Lifespan Regulation in Rats Kept Under Various Light Conditions. ( Anisimov, VN; Ilukha, VA; Ilyina, TN; Khizhkin, EA; Morozov, AV; Uzenbaeva, LB; Vinogradova, IA; Yunash, VD, 2017) |
| "The present study investigated the anti-aging effects of melatonin on the myocardial mitochondria of D-galactose-aged rats and associated mechanisms." | 3.85 | Anti‑aging effects of melatonin on the myocardial mitochondria of rats and associated mechanisms. ( Guo, XH; Li, YH; Zhai, YZ; Zhang, LC; Zhao, YS, 2017) |
| "Circadian disruptions can contribute to accelerated aging, and the circadian system regulates cognitive and physical functions; therefore, circadian markers (eg, melatonin) may be associated with key aspects of healthy aging and longevity." | 3.83 | Association of urinary melatonin levels and aging-related outcomes in older men. ( Ancoli-Israel, S; Barrett-Connor, E; Cawthon, PM; Devore, EE; Ensrud, K; Harrison, SL; Holton, KF; Orwoll, E; Redline, S; Schernhammer, ES; Stone, KL; Yaffe, K, 2016) |
| " In this study, we examined the underlying neuroprotective mechanism of melatonin against D-galactose-induced memory and synaptic dysfunction, elevated reactive oxygen species (ROS), neuroinflammation and neurodegeneration." | 3.81 | Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model. ( Ali, T; Badshah, H; Kim, MO; Kim, TH, 2015) |
| "Melatonin, an antioxidant in both animals and plants, has been reported to have beneficial effects on the aging process." | 3.81 | Melatonin delays leaf senescence and enhances salt stress tolerance in rice. ( Chen, SY; Chu, C; Hu, B; Li, W; Liang, C; Qian, Y; Tan, DX; Wang, H; Wang, Y; Wu, H; Zheng, G; Zhu, XG, 2015) |
| "The melatonin levels decreased with aging despite not reaching statistical significance, and the decrease was more evident in males than in females (40." | 3.80 | Melatonin and the Charlson Comorbidity Index (CCI): the Treviso Longeva (Trelong) study. ( Albani, D; Boldrini, P; Caberlotto, L; Di Giorgi, E; Durante, E; Flores-Obando, R; Forloni, G; Frigato, A; Gallucci, M; Mazzuco, S; Ongaro, F; Siculi, M; Taioli, E; Zanardo, A, 2014) |
| "This study aimed to investigate the potential protective effects of melatonin (Mel) against aluminium-induced neurodegenerative changes in aging Wistar rats (24-28months old)." | 3.80 | Effects of melatonin on aluminium-induced neurobehavioral and neurochemical changes in aging rats. ( Allagui, MS; Badraoui, R; Bouoni, Z; Elfeki, A; Feriani, A; Murat, JC; Nciri, R; Saoudi, M, 2014) |
| "The secretion of melatonin, a pleiotropic hormone mainly synthesized by the pineal gland, typically decreases with age and may be associated with the development of aging-related pathologic conditions such as cardiovascular disease." | 3.80 | Urine 6-sulfatoxymelatonin levels are inversely associated with arterial stiffness in post-menopausal women. ( Lee, DC; Lee, JY, 2014) |
| "Melatonin may have a preventive effect on atherosclerosis by regulating sleep quality and circadian biological rhythmicity." | 3.80 | Association between urinary 6-sulfatoxymelatonin excretion and arterial stiffness in the general elderly population: the HEIJO-KYO cohort. ( Kurumatani, N; Obayashi, K; Saeki, K, 2014) |
| " Moreover, the aging process is also associated with obesity and reduction in melatonin synthesis from the pineal gland and other organs." | 3.79 | Melatonin improves insulin sensitivity independently of weight loss in old obese rats. ( Bacurau, RF; Bordin, S; Camporez, JP; Caperuto, LC; Carpinelli, AR; Carvalho, CR; Cipolla-Neto, J; do Amaral, FG; Hirata, E; Marçal, AC; Peliciari-Garcia, RA; Ribeiro, LM; Siqueira-Filho, MA; Zanuto, R, 2013) |
| " Fluctuations of melatonin, ACTH, cortisol and thymic serum factor, which were exchanged in aging (the season peaks of hormones and its acrophase) were found in blood of healthy 20-29 years old people." | 3.79 | [The sexual peculiarities of aging changes in circannual rhythms of pineal gland, hypophysis, adrenal cortex and thymus functions in healthy subjects]. ( Labunets, IF, 2013) |
| "Decline with age of the content of melatonin is considered as one of the leading mechanisms of aging and development of associated diseases, including age-related macular degeneration (AMD)--the disease, which becomes the most common cause of blindness and acuity of vision deterioration in elderly." | 3.79 | [Potential of melatonin for prevention of age-related macular degeneration: experimental study]. ( Fursova, AZh; Kolosova, NG; Stefanova, NA; Zhdankina, AA, 2013) |
| "The aim of the present study was to investigate the effect of aging on several parameters related to glucose homeostasis and insulin resistance in pancreas and how melatonin administration could affect these parameters." | 3.79 | Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8). ( Cuesta, S; García, C; Kireev, R; Rancan, L; Tresguerres, JA; Vara, E, 2013) |
| " Several studies have suggested that the ability of light to modulate circadian entrainment and to induce acute effects on melatonin secretion, subjective alertness, and gene expression decreases during aging, particularly for blue light." | 3.78 | Does pupil constriction under blue and green monochromatic light exposure change with age? ( Carrier, J; Cooper, HM; Daneault, V; Doyon, J; Dumont, M; Gronfier, C; Hébert, M; Mure, LS; Teikari, P; Vandewalle, G, 2012) |
| "Melatonin has an important role in the aging process as a potential drug to relieve oxidative damage, a likely cause of age-associated brain dysfunction." | 3.76 | Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain. ( Aparicio, S; Barceló, P; Esteban, S; Fiol, MA; Garau, C; Moranta, D; Rial, R, 2010) |
| "This study investigated the effect of aging-related parameters such as inflammation, oxidative stress and cell death in the heart in an animal model of accelerated senescence and analyzed the effects of chronic administration of melatonin on these markers." | 3.76 | Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging. ( Acuña-Castroviejo, D; Cuesta, S; Forman, K; García, C; Kireev, R; Tresguerres, JA; Vara, E, 2010) |
| "This work was aimed at study changes of the epiphyseal melatonin-producing function in elderly patients with hypertensive disease, as well as the relationships of those changes with the degree of arterial hypertension and 24-hour arterial pressure profile disorders." | 3.76 | [Pineal gland melatonin-producing function in elderly patients with hypertensive disease: age peculiarities]. ( Antoniuk-Shcheglova, IA; Bondarenko, EV; Shatilo, VB, 2010) |
| "Aging is known to alter the circadian rhythms of melatonin, serotonin, thermoregulatory responses, cytokine production, and sleep/wakefulness which affect sleep quality." | 3.75 | Melatonin and tryptophan affect the activity-rest rhythm, core and peripheral temperatures, and interleukin levels in the ringdove: changes with age. ( Barriga, C; Bejarano, I; Espino, J; Marchena, AM; Paredes, SD; Reiter, RJ; Rial, RV; Rodríguez, AB, 2009) |
| "In the search of new therapeutic targets improving the quality of life of elderly, melatonin, "the chemical expression of darkness", seems to play a remarkable role in aging process possibly due to its antioxidant, immunoenhancer and anti-aging properties." | 3.75 | Age-related changes in melatonin synthesis in rat extrapineal tissues. ( Caballero, B; Carrascosa-Salmoral, MP; de la Lastra, CA; Gomez-Corvera, A; Guerrero, JM; Naranjo, MC; Sanchez-Hidalgo, M, 2009) |
| "The level of 6-oxymelatonin sulfate, the main metabolite of melatonin (MT), in morning urine samples from patients with metabolic syndrome (MS) suggests enhanced MT production at night." | 3.75 | [The role of melatonin in the development of metabolic syndrome]. ( Balliuzek, MF; Grinenko, TN; Kvetnaia, TV, 2009) |
| " The purpose of this study was to investigate melatonin levels in age-related macular degeneration (AMD) patients by measurement of 6-sulfatoxymelatonin levels (aMT6s), the major metabolite of melatonin in urine, and compare it with a group of age- and gender-matched controls." | 3.75 | Urinary 6-sulfatoxymelatonin level in age-related macular degeneration patients. ( Chen, M; Hu, DN; McCormick, SA; Perez, V; Rosen, R; Tai, K; Tone, P; Walsh, J; Yu, GP, 2009) |
| " The hormone melatonin also exhibits a number of such effects, and decrease in its level with age could explain the weakening of antioxidant protection upon aging." | 3.75 | New data on biochemical mechanism of programmed senescence of organisms and antioxidant defense of mitochondria. ( Skulachev, VP, 2009) |
| "The aim of this study was to investigate the effect of aging and ovariectomy on various physiological parameters related to inflammation and oxidative stress in livers obtained from old female rats, and the influence of chronic administration of melatonin on these animals." | 3.74 | Melatonin is able to prevent the liver of old castrated female rats from oxidative and pro-inflammatory damage. ( Ariznavarreta, C; Garcia, C; Kireev, RA; Tresguerres, AC; Tresguerres, JA; Vara, E, 2008) |
| " Since there is evidence that the endothelial dysfunction associated with aging may be partly related to the local formation of reactive oxygen species, the purpose of this study was to examine the effect of the natural antioxidant melatonin (10(-5)mol/l) on in vitro contractility of aged aortic rings under conditions of increased oxidative stress (40 m mol/l glucose concentration in medium)." | 3.74 | Effect of melatonin on vascular responses in aortic rings of aging rats. ( Cardinali, DP; Linares, LM; Obaya-Naredo, D; Pinto, JE; Planells, FM; Reyes-Toso, CF; Ricci, CR, 2007) |
| " Here we investigated the association between changes in bladder neuromuscular function and oxidative stress in aging and the possible benefits of melatonin treatment." | 3.74 | Aging impairs neurogenic contraction in guinea pig urinary bladder: role of oxidative stress and melatonin. ( Camello, PJ; Gómez-Pinilla, PJ; Pozo, MJ, 2007) |
| "The decrease of melatonin production with aging contributes to the decline in immune function as organisms age." | 3.74 | Effect of exogenous melatonin on viability, ingestion capacity, and free-radical scavenging in heterophils from young and old ringdoves (Streptopelia risoria). ( Barriga, C; Marchena, AM; Paredes, SD; Pariente, JA; Reiter, RJ; Rodríguez, AB; Terrón, MP, 2007) |
| "We examined the effect of daily melatonin supplementation on liver apoptosis induced by aging in rats." | 3.74 | Melatonin is able to reduce the apoptotic liver changes induced by aging via inhibition of the intrinsic pathway of apoptosis. ( Barrio, JP; García-Mediavilla, MV; González, P; González-Gallego, J; Mauriz, JL; Molpeceres, V, 2007) |
| "In the course of aging both monkeys and people reveal decreased night and average daily level of melatonin in the blood plasma and reduced hormone circadian rhythm amplitude, which evidence the disorder of the pineal gland melatonin releasing function." | 3.74 | [Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people]. ( Antoniuk-Shcheglova, IA; Goncharova, ND; Khavinson, VKh; Korkushko, OV; Lapin, BA; Magdich, LV; Shatilo, VB; Vengerin, AA, 2007) |
| " This study evaluates the effects of aging on detrusor myogenic contractile responses and the impact of melatonin treatment." | 3.74 | Melatonin restores impaired contractility in aged guinea pig urinary bladder. ( Andersson, KE; Camello, PJ; Gomez, MF; Gomez-Pinilla, PJ; Hedlund, P; Hellstrand, P; Pozo, MJ; Swärd, K, 2008) |
| "Previous data from our group have provided support for the role of GH, melatonin and estrogens in the prevention of aging of several physiological parameters from bone, liver metabolism, vascular activity, the central nervous system (CNS), the immune system and the skin." | 3.74 | Molecular mechanisms involved in the hormonal prevention of aging in the rat. ( Ariznavarreta, C; Borras, C; Kireev, R; Tresguerres, AF; Tresguerres, JA; Vara, E, 2008) |
| "During two years the influence of light regimens (standard lightning--LD, constant lightning--LL, natural lightning of the North-West of Russia--NL) and of melatonin on the development of metabolic syndrome of ageing LIO rats was studied." | 3.74 | [Effect of different light regimens on the development of metabolic syndrome of aging rats]. ( Vinogradova, IA, 2007) |
| "It was investigated the influence of pineal gland's peptides (epithalamin, epithalon) and indols (melatonin) on the aging changes of circannual rhythms of stromal cells-precurcors (CFC-F), granulocyte-macrophage cells-precurcors (CFC-GM), CD4+, Mac-1+ and CD19+-cells amount in bone marrow of mice CBA." | 3.74 | [Circannual rhythms of bone marrow cell composition in animals during aging: the role of pineal factors]. ( Labunets', IF, 2007) |
| " In addition, little evidence exists on the ability of melatonin to palliate the effects of aging on Ca(2+) signals and mitochondrial potential, a parameter involved in both Ca(2+) signaling and aging." | 3.74 | Age-related alterations in Ca2+ signals and mitochondrial membrane potential in exocrine cells are prevented by melatonin. ( Camello, PJ; Camello-Almaraz, C; Gomez-Pinilla, PJ; Pozo, MJ, 2008) |
| " Recent research has identified some of the likely molecular mediators of these potentially broad-ranging, health-enhancing and anti-aging effects; these include DHEA, interleukins -10 and -4 (IL-10, 1L-4), and especially melatonin." | 3.73 | From molecular biology to anti-aging cognitive-behavioral practices: the pioneering research of Walter Pierpaoli on the pineal and bone marrow foreshadows the contemporary revolution in stem cell and regenerative biology. ( Bushell, WC, 2005) |
| "The aim of our study was to assess the blood concentrations of some trace elements and melatonin (MLT) in patients with intervertebral disc herniation (IDH) and to investigate the interaction of histological and biochemical degeneration findings with aging." | 3.73 | Correlation of serum trace elements and melatonin levels to radiological, biochemical, and histological assessment of degeneration in patients with intervertebral disc herniation. ( Akyüz, O; Biçakçi, T; Erkus, M; Ozsunar, Y; Turgut, M; Yenisey, C, 2006) |
| "Aging is characterized by changes in the circadian rhythms of melatonin, serotonin, and sleep/wakefulness, alterations that affect sleep quality." | 3.73 | Comparative study of the activity/rest rhythms in young and old ringdove (Streptopelia risoria): correlation with serum levels of melatonin and serotonin. ( Barriga, C; Cubero, J; Paredes, SD; Reiter, RJ; Rodríguez, AB; Terrón, MP; Valero, V, 2006) |
| "In two previous communications to the RANM four and two years ago, some data were shown supporting the role of GH, Melatonin and Estrogens in the prevention of aging in a group of physiological parameters including bone, liver metabolism and vascular activity, the Central nervous System (CNS,) the immune system and the skin." | 3.73 | [Molecular mechanisms of aging and its prevention by hormonal treatment in rats]. ( Fernández-Tresguerres Hernández, JA, 2006) |
| "Both plasma melatonin levels and hypothalamic arcuate nucleus pro-opiomelanocortin (POMC) (biosynthetic precursor to the endogenous opioid ss-endorphin and other opiomelanocortins) mRNA content decrease with aging." | 3.72 | Suppression of hypothalamic pro-opiomelanocortin (POMC) gene expression by daily melatonin supplementation in aging rats. ( Boldt, BM; Marck, BT; Matsumoto, AM; Rasmussen, DD; Yellon, SM, 2003) |
| "Melatonin deprival in young rats induces alterations in cerebral arteriolar wall similar to those observed during aging: atrophy and a decrease in distensibility." | 3.72 | Impact of treatment with melatonin on cerebral circulation in old rats. ( Atkinson, J; Chillon, JM; Delagrange, P; Dupuis, F; Limiñana, P; Régrigny, O; Scalbert, E, 2004) |
| "Melatonin levels decrease with aging in mice." | 3.72 | Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex. ( Bondy, SC; Chen, D; Ge, YW; Lahiri, DK; Sharman, EH, 2004) |
| "Melatonin secretion is an endogenous synchronizer, and it may possess some anti-aging properties." | 3.72 | Qualitative and quantitative changes of melatonin levels in physiological and pathological aging and in centenarians. ( Cinchetti, W; Cravello, L; Ferrari, E; Fioravanti, M; Guazzoni, V; Magri, F; Sarra, S, 2004) |
| " Among studied agents were ethanol, tobacco smoke, irradiation, aging (as PSEE inductors) and carnosine, N-acetylcystein, vit." | 3.72 | [Switching off the estrogen effect and approaches to its correction]. ( Bershteĭn, LM; Kovalenko, IG; Poroshina, TE; Tsyrlina, EV; Vasil'ev, DA, 2003) |
| "The effects of a melatonin agonist, S-20098, included in the diet were tested on a specific effect of aging in hamsters: the marked decline in the phase shifting effects of a 6-h pulse of darkness on a background of constant light." | 3.71 | Melatonin or a melatonin agonist corrects age-related changes in circadian response to environmental stimulus. ( Maccari, S; Mocaer, E; Olivares, E; Turek, FW; Van Reeth, O; Weibel, L, 2001) |
| "It is generally accepted that antioxidant properties of melatonin significantly contribute to its antiaging effect." | 3.71 | Antioxidant and antiaging activity of N-acetylserotonin and melatonin in the in vivo models. ( Bachurin, S; Oxenkrug, G; Requintina, P, 2001) |
| "Pineal melatonin secretion has been reported to commonly decrease with aging, whereas intra-abdominal adiposity, plasma insulin and plasma leptin levels tend to increase." | 3.71 | Aging-dependent changes in the effect of daily melatonin supplementation on rat metabolic and behavioral responses. ( Larsen, SA; Mitton, DR; Rasmussen, DD; Yellon, SM, 2001) |
| " To assess the effect of aging and accelerated aging on the circadian pacemaker of this primate, we measured body weight variations, the daily rhythm in urine 6-sulfatoxymelatonin and the light-induced expression of the immediate early gene (Fos) in the suprachiasmatic nucleus of mouse lemurs that had been exposed to different photoperiodic cycles." | 3.71 | Artificially accelerated aging by shortened photoperiod alters early gene expression (Fos) in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, Microcebus murinus. ( Aujard, F; Claustrat, B; Cooper, HM; Dkhissi-Benyahya, O; Fournier, I; Perret, M; Schilling, A, 2001) |
| "Aging alters many aspects of circadian rhythmicity, including responsivity to phase-shifting stimuli and the amplitude of the rhythm of melatonin secretion." | 3.71 | Feeding melatonin enhances the phase shifting response to triazolam in both young and old golden hamsters. ( Bennett, KM; Dutton-Boilek, J; Horton, TH; Kolker, DE; Losee Olson, S; Turek, FW; Wallen, EP, 2002) |
| "Mitochondrial oxidative damage from free radicals may be a factor underlying aging, and melatonin, a powerful free radical scavenger, may participate in mitochondrial metabolism." | 3.71 | Melatonin protects hepatic mitochondrial respiratory chain activity in senescence-accelerated mice. ( Okatani, Y; Reiter, RJ; Wakatsuki, A, 2002) |
| "As previous studies have suggested that melatonin and serotonin may be involved in the regulation of intraocular pressure, retinal concentrations of melatonin, 5-HT, and related indoleamines measured at day and at night were studied during the development of a glaucoma-like disorder with increased intraocular pressure in the al mutant quail." | 3.70 | Day and night dysfunction in intraretinal melatonin and related indoleamines metabolism, correlated with the development of glaucoma-like disorder in an avian model. ( Chanut, E; Dkhissi, O; Nguyen-Legros, J; Repérant, J; Trouvin, JH; Versaux-Botteri, C, 1998) |
| "Human and rat pineal melatonin secretion decline with aging, whereas visceral fat and plasma insulin levels increase." | 3.70 | Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels. ( Boldt, BM; Matsumoto, AM; Rasmussen, DD; Wilkinson, CW; Yellon, SM, 1999) |
| "Our results suggest that increased levels of lipid peroxidation products may have a role in aging, and exogenous melatonin may delay the aging process of tissues by means of its free radical scavenging effects." | 3.70 | Differential effects of pharmacological doses of melatonin on malondialdehyde and glutathione levels in young and old rats. ( Akbulut, H; Gonca Akbulut, K; Gönü l, B, 1999) |
| "To study the effects of melatonin (Mel) on cortical intrasynaptosomal calcium concentration in old mice and on [Ca2+]i elevation induced by Bay-K-8644, KCl, and sodium l-glutamate in isolated brain cells of neonatal mouse, and to determine the antiaging mechanism of Mel." | 3.70 | Inhibitory effects of melatonin on free intracellular calcium in mouse brain cells. ( Zhang, JT; Zhang, QZ, 1999) |
| "These results do not support the hypothesis that reduction of plasma melatonin concentration is a general characteristic of healthy aging." | 3.70 | Do plasma melatonin concentrations decline with age? ( Czeisler, CA; Daniels, JE; Dijk, DJ; Duffy, JF; Klerman, EB; Shanahan, TL; Zeitzer, JM, 1999) |
| "The effect of aging and melatonin on in vitro pituitary responsiveness to luteinizing hormone-releasing hormone (LHRH) was studied." | 3.70 | In vitro pituitary responsiveness to LHRH in young and old female rats. Influence of melatonin. ( Díaz López, B; Díaz Rodriguez, E; Esquifino Parras, A; Fernández Alvarez, C; Marín Fernández, B; Pazo Vinuesa, D, 1999) |
| "During the aging process, a number of morphological and neurochemical alterations have been found in the supra-chiasmatic nuclei, which are in part responsible for the age-dependent decrease in plasma testosterone (andropause or PADAM), DHEA (adrenopause), GH/IGF-I (somatopause) and melatonin that develops in most men at about the age of 50 (Perry, 1999; Vermeulen et al." | 3.70 | Hormonal deficiency in elderly males. ( Cheng Xu, Y; Qian, SZ; Zhang, J, 2000) |
| "Relatively little is known about the effects of melatonin on the aging of the pineal, the organ which is the main place for synthesis of this hormone." | 3.70 | Age-related morphometric changes in the pineal gland. A comparative study between C57BL/6J and CBA mice. ( Alvarez-Uría, M; Cernuda-Cernuda, R; García-Fernández, JM; Huerta, JJ; Muñoz Llamosas, M, 2000) |
| "The simultaneous evaluation of the circadian rhythm of plasma melatonin and ACTH and of serum cortisol and DHEAS represents a clinically reliable tool to appreciate the neuroendocrine changes occurring in physiological and pathological brain aging." | 3.70 | Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia. ( Arcaini, A; Cravello, L; Ferrari, E; Fioravanti, M; Gornati, R; Magri, F; Pelanconi, L; Solerte, SB, 2000) |
| "To observe the effects of melatonin (Mel) on glutamate (Glu) release from the cortical synaptosomes in old mice and on neurotoxicity induced by KCl, Glu in cultured cortical cells of fetal rat and to explore the antiaging mechanism of Mel." | 3.70 | Antagonistic effects of melatonin on glutamate release and neurotoxicity in cerebral cortex. ( Gong, YS; Zhang, JT; Zhang, QZ, 1999) |
| "To examine the effects of melatonin on the dynamic changes in the concentration of intracellular free Ca2+ ([Ca2+]i) in single intact cultured cortical neurons isolated from fetal rats, in order to explore the possible antiaging mechanisms of melatonin (MT)." | 3.70 | [Effect of melatonin on the spatial and temporal changes of [Ca2+]i in single living cells of cortical neurons by laser scanning confocal microscopy]. ( Zhang, J; Zhang, Q, 2000) |
| "Melatonin, the main hormone of the pineal gland, when chronically injected into young mice or mice immunodepressed by aging or by cyclophosphamide treatment, was able to enhance the antibody response to a T-dependent antigen." | 3.69 | Melatonin restores immunodepression in aged and cyclophosphamide-treated mice. ( Caroleo, MC; Doria, G; Nisticò, G, 1994) |
| "Melatonin, the hormone of the pineal gland, which in animal studies has been found to inhibit aging processes, is secreted in smaller amounts towards senescence." | 3.69 | Decrease in melatonin precedes follicle-stimulating hormone increase during perimenopause. ( Kauppila, A; Kivelä, A; Leppäluoto, J; Vakkuri, O; Valtonen, M, 1996) |
| " One measurable variable of the ageing process may be melatonin, known to decrease with age and to be lower in patients with coronary heart disease than in normal individuals." | 3.69 | Premature ageing: the link between psychosocial risk factors and disease. ( Nilsson, PM, 1996) |
| "Sequential measures of daytime and nighttime sulphatoxy-melatonin (aMT6s) in 10 female patients with anorexia nervosa (AN) and 12 female patients with concurrent AN with bulimic symptoms (AN + BN) were compared with 13 female control subjects." | 3.68 | The acute effects of starvation on 6-sulphatoxy-melatonin output in subgroups of patients with anorexia nervosa. ( Brown, GM; Ford, CG; Kennedy, SH; Ralevski, E, 1993) |
| "Circadian, continued treatment with melatonin during the dark cycle produces changes in the blood level of thyroid hormones in aging mice." | 3.68 | The involvement of pineal gland and melatonin in immunity and aging. I. Thymus-mediated, immunoreconstituting and antiviral activity of thyrotropin-releasing hormone. ( Pierpaoli, W; Yi, C, 1990) |
| "Effects of aging and melatonin on testicular function of golden male hamsters were investigated." | 3.66 | Spontaneous and melatonin-induced testicular regression in male golden hamsters: augmented sensitivity of the old male to melatonin inhibition. ( Chen, HJ, 1981) |
| "Melatonin is a sleep-promoting agent, with waste clearance from the CNS being highest especially during slow wave sleep." | 3.01 | Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm. ( Cucielo, MS; de Almeida Chuffa, LG; Gancitano, G; Reiter, RJ; Rosales-Corral, S; Sharma, R; Tan, DX, 2023) |
| "Diseases such as Alzheimer's, type 2 diabetes mellitus (T2DM), Parkinson's, atherosclerosis, hypertension, and osteoarthritis are age-related, and most of these diseases are comorbidities or risk factors for AD; however, our understandings of molecular events that regulate the occurrence of these diseases are still not fully understood." | 2.82 | Importance of Bmal1 in Alzheimer's disease and associated aging-related diseases: Mechanisms and interventions. ( Chen, J; Dong, K; Fan, R; Ma, D; Peng, X; Shi, X; Xie, L; Xu, W; Yang, Y; Yu, X; Zhang, S, 2022) |
| "Melatonin treatment of intact gilts failed to advance the age of puberty irrespective of their season of birth (P>0." | 2.80 | Melatonin implants do not alter estrogen feedback or advance puberty in gilts. ( Hughes, PE; Kennaway, DJ; van Wettere, WH, 2015) |
| "Melatonin is a biological hormone produced by the body that has good free radical scavenging effects, antioxidant effects and other effects." | 2.72 | The role of melatonin in sarcopenia: Advances and application prospects. ( He, M; Hu, P; Jin, H; Li, Y; Tang, K; Wang, X; Wu, Y; Xie, W; Yu, D, 2021) |
| "Melatonin is a promising therapeutic candidate due to its pleiotropic actions." | 2.72 | Melatonin to Rescue the Aged Heart: Antiarrhythmic and Antioxidant Benefits. ( Diez, ER; Pueyo, E; Segovia-Roldan, M, 2021) |
| "Melatonin is an ancient molecule that is evident in high concentrations in various tissues throughout the body." | 2.72 | Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders. ( Brown, GM; Gonçalves, VF; Kennedy, JL; Melhuish Beaupre, LM, 2021) |
| "With melatonin treatment, the MESOR was lower by 0." | 2.72 | The circadian body temperature rhythm in the elderly: effect of single daily melatonin dosing. ( Gubin, DG; Gubin, GD; Waterhouse, J; Weinert, D, 2006) |
| "Melatonin has been shown to have the capacity to control eye pigmentation and thereby regulate the amount of light reaching the photoreceptors, to scavenge hydroxyradicals and to protect retinal pigment epithelium (RPE) cells from oxidative damage." | 2.71 | Effects of melatonin in age-related macular degeneration. ( Guo, M; Pan, X; Pierpaoli, W; Yan, H; Yi, C, 2005) |
| "Melatonin is a neuroregulator hormone that has free radical scavenger, strong antioxidant, anti-inflammatory, and immunosuppressive actions." | 2.66 | Melatonin: A review of its potential functions and effects on neurological diseases. ( Acet, HA; Gunata, M; Parlakpinar, H, 2020) |
| "Melatonin is a potent antioxidant and antiageing molecule, is nontoxic, and enhances the efficacy and reduces the side effects of chemotherapy." | 2.66 | Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing. ( Di, S; Han, J; Li, W; Li, X; Liu, D; Ma, Z; Reiter, RJ; Xu, L; Yan, X; Zhang, J; Zhang, X, 2020) |
| "Melatonin is a neuroendocrine hormone mainly synthesized in the pineal gland and exhibits a wide range of biological functions, such as sleep control, regulating circadian rhythm, immune enhancement, metabolism regulation, antioxidant, anti-aging, and anti-tumor effects." | 2.66 | Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases. ( Akbar, M; Luo, F; Rungratanawanich, W; Sandhu, AF; Song, BJ; Wang, X; Williams, GE; Zhou, S, 2020) |
| "Colorectal cancer is one of the most common cancers among the elderly, which is also seen in the forms of hereditary syndromes occurring in younger individuals." | 2.66 | Melatonin: An important anticancer agent in colorectal cancer. ( Ghazizadeh, S; Gholamzadeh, S; Majidinia, M; Mihanfar, A; Mirza-Aghazadeh-Attari, M; Mohammadzadeh, A; Mostavafi, S; Sadighparvar, S; Yousefi, B, 2020) |
| "Although current therapies in chronic obstructive pulmonary disease (COPD) improve the quality of life, they do not satisfactorily reduce disease progression or mortality." | 2.55 | Geroprotectors as a therapeutic strategy for COPD - where are we now? ( Białas, AJ; Górski, P; Makowska, J; Miłkowska-Dymanowska, J; Piotrowski, WJ; Wardzynska, A, 2017) |
| "Cardiovascular diseases are one of the most common causes of mortality and morbidity among elderly subjects worldwide." | 2.55 | Melatonin: Protection against age-related cardiac pathology. ( Buffoli, B; Favero, G; Franceschetti, L; Moghadasian, MH; Reiter, RJ; Rezzani, R; Rodella, LF, 2017) |
| "Melatonin plays a major role in maintaining circadian rhythm." | 2.53 | Physiological melatonin levels in healthy older people: A systematic review. ( de Rooij, SE; Scholtens, RM; van Kempen, MF; van Munster, BC, 2016) |
| "Melatonin is a highly effective and ubiquitously acting antioxidant and free radical scavenger that is normally produced in all organisms." | 2.53 | Melatonin as a Potential Agent in the Treatment of Sarcopenia. ( Boga, JA; Coto-Montes, A; Reiter, RJ; Tan, DX, 2016) |
| "Melatonin is a neurohormone secreted mainly by the pineal gland that controls circadian rhythm, which is primarily regulated by light." | 2.52 | Melatonin in aging women. ( Caglar, GS; Gursoy, AY; Kiseli, M, 2015) |
| "The aging risk factor for Parkinson's disease is described in terms of specific disease markers including mitochondrial and gene dysfunctions relevant to energy metabolism." | 2.50 | Management of the aging risk factor for Parkinson's disease. ( Phillipson, OT, 2014) |
| "Melatonin is an indoleamine that modulates a wide variety of endocrine, neural and immune functions." | 2.50 | Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review. ( Almeida-Souza, P; Bernal-Pérez, M; Escudero, P; García, JJ; García-Gil, FA; López-Pingarrón, L; Ramírez, JM; Reiter, RJ; Tan, DX; Tres, A, 2014) |
| "Circadian rhythm sleep disorders are caused by the disturbance of sleep-wake regulation in the central nervous system, disturbed input into the sensory organs, and decreased social activities." | 2.50 | [Sleep problems in dementia]. ( Oka, Y, 2014) |
| "This is as true of cancer as it is of the development of cardiovascular, autoimmune, and neurodegenerative disease, in all of these immunological surveillance break downs, leading to an unraveling of the neuroimmunoendocrine process that inhibits proliferation of preneoplastic and neoplastic cells already existing in the body." | 2.49 | Cancer and the endogenous "pineal clock": a means of early diagnosis and successful treatment as well as prevention of cancers. ( Pierpaoli, W, 2013) |
| " The recognition of the periodicity of biological processes makes the optimal dosing of certain drugs feasible." | 2.48 | [Physiological and pathophysiological role of the circadian clock system]. ( Halmos, T; Suba, I, 2012) |
| "Melatonin treatment was able to reduce the fat content of the hypodermis and to increase Bcl2 and reduce nucleosomes, caspases, and LPO in keratinocytes." | 2.48 | Effect of chronic melatonin administration on several physiological parameters from old Wistar rats and SAMP8 mice. ( Cuesta, S; Forman, K; Kireev, R; Tresguerres, AF; Tresguerres, JA; Vara, E, 2012) |
| "Melatonin is a known powerful antioxidant and anti-inflammatory and increasing experimental and clinical evidence shows its beneficial effects against oxidative/nitrosative stress status, including that involving mitochondrial dysfunction." | 2.47 | Melatonin-mitochondria interplay in health and disease. ( Acuña Castroviejo, D; Escames, G; García, JA; López, A; López, LC; Reiter, RJ, 2011) |
| "Type 2 diabetes is a metabolic disease, which frequency increases substantially with age." | 2.46 | [Melatonin and oxidative stress in elderly patients with type 2 diabetes]. ( Kedziora, J; Kedziora-Kornatowska, K; Kupczyk, D; Rybka, J, 2010) |
| "Ramelteon is a novel MT(1) and MT(2) melatonergic agonist that has specific effects on melatonin receptors in the SCN and is effective in promoting sleep in experimental animals such as cats and monkeys." | 2.45 | Melatonin and melatonergic drugs on sleep: possible mechanisms of action. ( Cardinali, DP; Hardeland, R; Pandi-Perumal, SR; Poeggeler, B; Spence, DW; Srinivasan, V; Trahkt, I, 2009) |
| "Melatonin has potential utility both in slowing normal brain aging and in treatment of neurodegenerative conditions." | 2.44 | Melatonin and the aging brain. ( Bondy, SC; Sharman, EH, 2007) |
| "Circadian rhythm disturbances, such as sleep disorders, are frequently seen in aging and are even more pronounced in Alzheimer's disease (AD)." | 2.44 | Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease. ( Swaab, DF; Wu, YH, 2007) |
| "Melatonin plays a role in maintaining sleep-wake rhythms; supplementation may help to regulate sleep disturbance that occur with jet lag, rotating shift-work and depression." | 2.44 | Neurobiological effects of melatonin as related to cancer. ( Hoang, BX; Levine, SA; Pham, PT; Shaw, DG, 2007) |
| "Melatonin not only plays an important role in the regulation of circadian rhythms, but also acts as antioxidant and neuroprotector that may be of importance in aging and Alzheimer's disease (AD)." | 2.43 | The human pineal gland and melatonin in aging and Alzheimer's disease. ( Swaab, DF; Wu, YH, 2005) |
| "Melatonin has been shown to be effective in arresting neurodegenerative phenomena seen in experimental models of Alzheimer's disease, Parkinsonism and ischemic stroke." | 2.43 | Role of melatonin in neurodegenerative diseases. ( Cardinali, DP; Esquifino, AI; Hardeland, R; Maestroni, GJ; Pandi-Perumal, SR; Srinivasan, V, 2005) |
| "Melatonin also has strong antioxidant properties (stronger than those of vitamin E), and an oncostatic action." | 2.43 | [Melatonin: what for?]. ( Touitou, Y, 2005) |
| "Melatonin is a product of the amino acid tryptophan in the pineal gland." | 2.43 | Melatonin and nitric oxide. ( Aydogan, S; Goktas, A; Yerer, MB, 2006) |
| "Melatonin has been detected in bacteria, eukaryotic unicells, macroalgae, plants, fungi and various taxa of invertebrates." | 2.42 | Non-vertebrate melatonin. ( Hardeland, R; Poeggeler, B, 2003) |
| "Melatonin has been successfully used to alleviate jet lag symptoms of travellers and there is also a smaller amount of evidence that the hormone helps shiftworkers adjust to nocturnal regimens." | 2.42 | The relevance of melatonin to sports medicine and science. ( Atkinson, G; Drust, B; Reilly, T; Waterhouse, J, 2003) |
| "Melatonin has attained increasing prominence as a candidate for ameliorating these changes occurring during senescence." | 2.42 | Retardation of brain aging by chronic treatment with melatonin. ( Bondy, SC; Campbell, A; Lahiri, DK; Perreau, VM; Sharman, EH; Sharman, KZ; Zhou, J, 2004) |
| "Melatonin potentially plays an important role in aging, prolongation of life span, and health in the aged individual." | 2.42 | Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders. ( Bondy, S; Chen, D; Greig, NH; Lahiri, DK; Lahiri, P; Rogers, JT, 2004) |
| "Melatonin is a hormone produced in human by the pineal body, the endocrine gland localized in the central part of cerebrum." | 2.42 | [Melatonin and its biological significance]. ( Boguszewska, A; Pasternak, K, 2004) |
| "Melatonin has several distinct advantages as a preserver of organelle structure and function." | 2.41 | Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin. ( Burkhardt, S; Reiter, RJ; Tan, DX, 2002) |
| "Melatonin is a hormone secreted during the dark period of the day." | 2.40 | [Melatonin in the human--an overview]. ( Hartmann, J; Langer, M; Turkof, H; Waldhauser, F, 1997) |
| "Melatonin is a hormone secreted by the pineal gland in response to photoperiods and influences many important biological processes." | 2.40 | Melatonin, immune modulation and aging. ( Ardestani, SK; Elliott, KK; Inserra, PF; Liang, B; Molitor, M; Watson, RR; Zhang, Z, 1997) |
| "Melatonin is a very potent and efficient endogenous radical scavenger." | 2.38 | Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis. ( Chen, LD; Manchester, LC; Poeggeler, B; Reiter, RJ; Tan, DX, 1993) |
| "Melatonin has now been shown to be a potent immunoregulatory agent, and to be able to antagonize the immunosuppressive effects of acute anxiety stress in mice, as measured by antibody production, by thymus weight, and by the capacity of stressed- and evening-melatonin-treated mice to react against a lethal virus." | 2.37 | Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its anti-aging effects. ( Maestroni, GJ; Pierpaoli, W, 1987) |
| "Melatonin (MLT) is an endogenously created indole derivative that modifies several tasks, involving mitochondria-associated activities." | 1.91 | Melatonin as mitochondria-targeted drug. ( Saso, L; Suzen, S, 2023) |
| "Human skin aging is associated with functional deterioration on multiple levels of physiology, necessitating the development of effective skin senotherapeutics." | 1.91 | Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo. ( Akhundlu, A; Chéret, J; Gherardini, J; Gomez-Gomez, T; Gompels, M; Lee, WW; Linowiecka, K; Lopez de Mendoza, G; Paus, R; Samra, T, 2023) |
| "Melatonin was added to the perfusion solution five minutes prior to and until 15 min after the start of reperfusion." | 1.62 | Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats. ( Badalzadeh, R; Feyzizadeh, S; Hosseini, L; Høilund-Carlsen, PF; Jafari-Azad, A; Rajabi, M; Vafaee, MS, 2021) |
| "Melatonin (MT) is an endogenous hormone mainly synthesized by pineal cells, which has strong endogenous effects of eliminating free radicals and resisting oxidative damages." | 1.62 | Research progress of melatonin (MT) in improving ovarian function: a review of the current status. ( Chen, X; Guo, YM; Sun, TC; Wang, HP, 2021) |
| "Melatonin (MT) has been demonstrated to impact the cardiovascular system." | 1.56 | Melatonin alleviates vascular calcification and ageing through exosomal miR-204/miR-211 cluster in a paracrine manner. ( Cui, RR; Guo, B; Li, F; Liao, XB; Lin, X; Liu, YS; Shan, SK; Wang, Y; Wu, F; Xu, F; Yuan, LQ; Zheng, MH; Zhong, JY; Zhou, E, 2020) |
| "We found that Huntington's disease mice had increased mtDNA release, cGAS activation, and inflammation, all inhibited by exogenous melatonin." | 1.56 | Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration. ( Baranov, SV; Carlisle, DL; Friedlander, RM; Jauhari, A; Kim, J; Li, F; Minnigh, MB; Oberly, P; Poloyac, SM; Singh, T; Suofu, Y; Wang, X; Yablonska, S, 2020) |
| "Relative to genomic instability, melatonin was effective in reducing DNA damage caused by ageing, presenting antigenotoxic and antimutagenic activities, independently of initiation age." | 1.56 | Melatonin supplementation over different time periods until ageing modulates genotoxic parameters in mice. ( Damiani, AP; de Andrade, VM; de Oliveira Sardinha, TT; de Pinho, RA; Gajski, G; Rohr, P; Strapazzon, G, 2020) |
| "Melatonin has recently been found to be a possible new regulator of bone metabolism." | 1.56 | Oral administration of melatonin contained in drinking water increased bone strength in naturally aged mice. ( Hattori, A; Hirata, K; Hirayama, J; Honda, M; Igarashi-Migitaka, J; Ikegame, M; Kamijo-Ikemori, A; Maruyama, Y; Matsubara, H; Mishima, H; Seki, A; Sekiguchi, T; Shimizu, N; Srivastav, AK; Suzuki, N, 2020) |
| " Here, we tested the effect of chronic administration of melatonin (MLT) on brain insulin resistance and cognition deficits caused by a high-fat diet (HFD) in aged rats." | 1.51 | Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet. ( Chen, M; Deng, Q; Gao, H; Huang, F; Huang, Q; Ma, C; Rong, S; Xu, J; Yang, W; Zhang, L, 2019) |
| " The survey of Caenorhabditis elegans, which depends on time and dosage as the main outcome measures, was examined microscopically." | 1.51 | The physiological and lifespan alterations in Caenorhabditis elegans exposed to different dosages of melatonin. ( Bilgic, E; Karadas, O; Karadas, S; Ozcelik, F; Ozpinar, N, 2019) |
| "Children are more susceptible to Giardia lamblia infection." | 1.48 | Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age. ( Fagundes, DLG; Fernandes, RTS; França, EL; França-Botelho, ADC; Gomes, MA; Hara, CCP; Honorio-França, AC; Pereira, QLC, 2018) |
| "Melatonin has been considered as an effective remedy for circadian rhythm shift." | 1.48 | Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice. ( Chu, S; Cui, Y; Gu, X; Li, X; Ma, Z; Qian, Y; Shao, X; Song, J; Xia, T; Xu, F, 2018) |
| " A histological analysis revealed that chronic intake of MEL diminished the age-dependent changes in the structure of muscle fibers of the left ventricle, muscle fiber swelling, and injury zones characteristic of acute cardiac failure caused by ISO." | 1.48 | Effect of Melatonin on Rat Heart Mitochondria in Acute Heart Failure in Aged Rats. ( Akatov, V; Baburina, Y; Fadeeva, I; Krestinina, O; Kruglov, A; Odinokova, I; Sotnikova, L; Zvyagina, A, 2018) |
| " Dose-response curves for pupillary constriction to 469-nm blue light and 631-nm red light were compared between young normal adults aged 21-30 years (n = 60) and older adults aged ≥50 years (normal, n = 54; mild cataract, n = 107; severe cataract, n = 18)." | 1.46 | Pupillary responses to short-wavelength light are preserved in aging. ( Aung, T; Gooley, JJ; Milea, D; Rukmini, AV, 2017) |
| "Melatonin treatment with either dose reversed the aging-derived inflammation (p<0." | 1.43 | Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model. ( Carrasco, A; Escames, G; Paredes, SD; Puig, Á; Rancan, L; Tresguerres, JA; Vara, E, 2016) |
| " The long-term administration of melatonin, mice had shorter escape latencies and remained in the target quadrant longer compared to the aged group." | 1.43 | Melatonin administration reverses the alteration of amyloid precursor protein-cleaving secretases expression in aged mouse hippocampus. ( Boontem, P; Govitrapong, P; Mukda, S; Panmanee, J, 2016) |
| "Melatonin treatment suppressed ovarian mitochondrial oxidative damage by decreasing mitochondrial reactive oxygen species (mROS) generation, inhibiting apoptosis, repressing collapse of mitochondrial membrane potential and preserving respiratory chain complex activities." | 1.43 | Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice. ( Fu, B; Mao, T; Peng, W; Song, C; Wu, H; Yin, S; Zhang, J; Zhang, Y; Zhao, J, 2016) |
| "Melatonin treatment significantly affected total activity time, number of lateral approaches and mount attempts in comparison to controls." | 1.42 | Melatonin administration enhances the reproductive capacity of young rams under a southern Mediterranean environment. ( Ben Salem, I; Fehri, Y; Hilali, ME; Lassoued, N; Rekik, M; Sakly, C; Taboubi, R, 2015) |
| " However, chronic intake of melatonin (1mg/kg/day, diluted in drinking water, 4 weeks) increased TPH-1 activity and significantly improved the age-induced deficits in nocturnal melatonin content in the pineal gland." | 1.40 | Intake of melatonin increases tryptophan hydroxylase type 1 activity in aged rats: Preliminary study. ( Aparicio, S; Barceló, P; Esteban, S; Garau, C; Moranta, D; Nicolau, C; Ramis, M; Sarubbo, F, 2014) |
| "Rats treated with melatonin had higher bone volume, bone trabecular number, trabecular thickness, and cortical thickness in comparison to the control group." | 1.40 | Melatonin dietary supplement as an anti-aging therapy for age-related bone loss. ( Barralet, JE; Calvo-Guirado, JL; Eimar, H; Prieto, S; Tamimi, F; Torres, J; Tresguerres, IF; Tresguerres, JA, 2014) |
| "Treatment with melatonin significantly increased the number of neurospheres in a concentration-dependent manner and up-regulated nestin protein." | 1.40 | Melatonin enhances adult rat hippocampal progenitor cell proliferation via ERK signaling pathway through melatonin receptor. ( Ekthuwapranee, K; Govitrapong, P; Junmanee, T; Puriboriboon, Y; Tocharus, C; Tocharus, J, 2014) |
| "Melatonin was shown to decrease the level of mRNA for AhR-dependent genes of CYP1A2 and CYP1B1 cytochromes in the retina, but had no effect on the content of mRNA for Nrf2-dependent genes in OXYS rats." | 1.40 | Expression of genes for AhR and Nrf2 signal pathways in the retina of OXYS rats during the development of retinopathy and melatonin-induced changes in this process. ( Grishanova, AY; Perepechaeva, ML; Stefanova, NA, 2014) |
| "Melatonin treatment improved the regularity, fragmentation and amplitude of the RAR in senescent fish, and it also improved sleep efficiency." | 1.39 | Rest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonin. ( Almaida-Pagán, PF; de Costa, J; Lucas-Sánchez, A; Madrid, JA; Martinez-Nicolas, A; Mendiola, P, 2013) |
| "Melatonin has free radical scavenging ability besides its classical role as a hormonal signaling agent." | 1.39 | Attenuation of age-related increase of protein carbonylation in the liver of mice by melatonin and curcumin. ( Dkhar, P; Sharma, R, 2013) |
| "Melatonin has been suggested as an effective free radical scavenger that might have a role during the process of aging." | 1.39 | Improvement of oxidative stress and immunity by melatonin: an age dependent study in golden hamster. ( Dash, D; Haldar, C; Mukherjee, A; Nayak, MK; Vishwas, DK, 2013) |
| "Melatonin and estrogen treatment prevented the oxidative damage and the activation of caspases." | 1.38 | Aging-induced alterations in female rat colon smooth muscle: the protective effects of hormonal therapy. ( Camello, PJ; Camello-Almaraz, C; Fernández-Tresguerres, JA; Martin-Cano, FE; Pascua, P; Pozo, MJ; Vara, E, 2012) |
| "Melatonin is a key hormone in the synchronization of behaviors, metabolisms and physiological regulations with environmental factors." | 1.38 | [Cellular aspects of aging in the pineal gland of the shrew, Crocidura russula]. ( Bendjelloul, M; Besseau, L; Dekar-Madoui, A; Falcon, J; Fons, R; Magnanou, E; Ouali, S, 2012) |
| "But, melatonin treatment increased SOD activity in the aged rats." | 1.38 | Age-related changes in the rat brain mitochondrial antioxidative enzyme ratios: modulation by melatonin. ( Acuna-Castroviejo, D; Akbulut, KG; Güney, Ş; Öztürk, G, 2012) |
| "Treatment with melatonin prevented premature aging and tumorigenesis in rodents." | 1.38 | Light-at-night-induced circadian disruption, cancer and aging. ( Anisimov, VN; Panchenko, AV; Popovich, IG; Vinogradova, IA; Zabezhinski, MA, 2012) |
| "The melatonin effect was detected in aged rats and adult silver foxes and not observed in juvenile animals." | 1.38 | [The melatonin influences on neutrophils/lymphocytes ratio of mammals blood depends on age of animals]. ( Goranskiĭ, AI; Iliukha, VA; Kizhina, AG; Lapinski, S; Malkiel', AI; Prokopenko, OA; Uzenbaeva, LB; Vinogradova, IA, 2012) |
| "Tumors are commonly found during senescence of several strains of mice." | 1.37 | Extended exposure to dietary melatonin reduces tumor number and size in aged male mice. ( Bondy, SC; Sharman, EH; Sharman, KG, 2011) |
| "Melatonin treatment significantly reduced both hydrogen peroxide (H(2)O(2)) and superoxide anion levels, likely due to its free-radical scavenging properties, and enhanced leucocyte viability in both age groups." | 1.36 | Melatonin counteracts alterations in oxidative metabolism and cell viability induced by intracellular calcium overload in human leucocytes: changes with age. ( Barriga, C; Bejarano, I; Espino, J; González, D; Paredes, SD; Pariente, JA; Reiter, RJ; Rodríguez, AB, 2010) |
| "Melatonin treatment counteracted both these processes." | 1.36 | Increased susceptibility to Ca(2+)-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: effect of melatonin. ( Moro, N; Paradies, G; Paradies, V; Petrosillo, G; Ruggiero, FM, 2010) |
| "Sleep in older adults with Alzheimer's disease can often be extremely fragmented, thus disturbing normal sleep-wake rhythms." | 1.36 | Sleep in older adults with Alzheimer's disease. ( Dowling, GA; Lee, KA; Song, Y; Strawbridge, WJ; Wallhagen, MI, 2010) |
| "Treatment with melatonin decreased the mRNA expression of TNF-α, IL-1β, HO (HO-1 and HO-2), iNOS, MCP1, NFκB1, NFκB2 and NKAP in old male mice." | 1.36 | Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8). ( Ariznavarreta, C; Cuesta, S; Escames, G; Forman, K; García, C; Kireev, R; Tresguerres, JA; Vara, E, 2010) |
| "Melatonin has been shown to possess antioxidant properties and to reduce oxidant events in brain aging." | 1.35 | Melatonin prevents age-related mitochondrial dysfunction in rat brain via cardiolipin protection. ( Bertoni-Freddari, C; Fattoretti, P; Matera, M; Paradies, G; Petrosillo, G; Ruggiero, FM, 2008) |
| "Luzindole is an unselective antagonist of the melatonin receptors and melatonin's other binding sites, although some exceptions have been observed in chick retinal neurodevelopment, where this unselective antagonist does not block melatonin's inhibitory effect on the adenylate cyclase enzyme, probably due to the presence of some other melatonin receptor(s) or binding site(s)." | 1.35 | An unexpected effect of 5-MCA-NAT in chick retinal development. ( Sampaio, Lde F, 2009) |
| "Melatonin tended to enhance the reaction of younger animals to LPS but suppressed the inflammatory response of older mice." | 1.35 | Melatonin causes gene expression in aged animals to respond to inflammatory stimuli in a manner differing from that of young animals. ( Bondy, SC; Sharman, EH; Sharman, KG, 2008) |
| "Melatonin treatment obviously reduced the deposition of MSSG and elevated hippocampal pyramidal cell number while improving the learning and memory deficits of SAMP8." | 1.35 | Differential effects of melatonin on hippocampal neurodegeneration in different aged accelerated senescence prone mouse-8. ( Cheng, S; Fan, W; He, H; Ma, C; Pang, J; Qu, H, 2008) |
| "Treatment with melatonin in SAMP8 and SAMR1 mice reduced the neurodegenerative changes with an increase of ROR-alpha1 levels without an apparent influence in the levels of MT-1 receptor." | 1.35 | Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice. ( Caballero, B; Camins, A; Coto-Montes, A; De Gonzalo-Calvo, D; Gutierrez-Cuesta, J; Huidobro-Fernández, C; Pallas, M; Rodríguez-Colunga, MJ; Sierra, V; Soria-Valles, C; Tolivia, D; Vega-Naredo, I, 2008) |
| "Melatonin treatment markedly altered the response in gene expression of older animals subjected to an LPS challenge." | 1.34 | Melatonin treatment in old mice enables a more youthful response to LPS in the brain. ( Bondy, SC; Cotman, CW; Perreau, VM; Sharman, EH; Sharman, KG, 2007) |
| "To determine the effects of sleep and sleep deprivation on plasma melatonin concentrations in humans and whether these effects are age-dependent." | 1.34 | Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake. ( Czeisler, CA; Dijk, DJ; Duffy, JF; Lockley, SW; Zeitzer, JM, 2007) |
| "Melatonin has been proposed as a treatment for Alzheimer's disease based on the demonstration of antioxidant and "anti-amyloid" effects in vitro and in vivo." | 1.33 | Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials. ( Jones, R; Kulhanek, D; Nowlin, J; Praticò, D; Quinn, J; Rokach, J; Stackman, R, 2005) |
| "Melatonin is a secretory product with well-known antioxidant properties." | 1.33 | Effect of melatonin administration on parameters related to oxidative damage in hepatocytes isolated from old Wistar rats. ( Ariznavarreta, C; Castillo, C; Salazar, V; Tresguerres, JA; Vara, E, 2005) |
| "Melatonin or epitalon treatment was followed by longer mean and maximum survival in the 10% of the last survivors among SAMP-1." | 1.33 | [Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)]. ( Anisimov, VN; Iashin, AI; Khavinson, VKh; Popovich, IG; Rozenfel'd, SV; Semenchenko, AV; Zabezhinskiĭ, MA, 2005) |
| "Isoproterenol (10(-4)M) was infused for 20 min, 4h 10 min after the beginning of the perifusion." | 1.33 | Old rats are more sensitive to photoperiodic changes. A study on pineal melatonin. ( Charbuy, H; Djeridane, Y; Touitou, Y, 2005) |
| "Treatment with melatonin or coenzyme Q10 for 4 weeks reduced the lipofuscin content of the hippocampus and carbonyl level." | 1.33 | Age-associated changes in protein oxidation and proteasome activities in rat brain: modulation by antioxidants. ( Abd El Mohsen, MM; Fahim, AT; Iravani, MM; Ismail, NA; Jenner, P; Motawi, TM; Rose, S; Spencer, JP, 2005) |
| "Melatonin is an antioxidant and free radical scavenger." | 1.33 | Potent therapeutic effect of melatonin on aging skin in pinealectomized rats. ( Batçioğlu, K; Eşrefoğlu, M; Gül, M; Parlakpinar, H; Seyhan, M; Uyumlu, B, 2005) |
| "Melatonin improves learning and memory deficits and the behavioral responses of rats to melatonin supplementation are age dependent." | 1.33 | Comparison of the impact of melatonin on chronic ethanol-induced learning and memory impairment between young and aged rats. ( Baydas, G; Tuzcu, M; Yasar, A, 2005) |
| "Treatment of circadian rhythm disorders has led to the development of a new type of agent called "chronobiotics," among which melatonin is the prototype." | 1.33 | Clinical perspectives for the use of melatonin as a chronobiotic and cytoprotective agent. ( Cardinali, DP; Furio, AM; Reyes, MP, 2005) |
| "This melatonin effect was strong in PX rats but relatively weak in SX rats." | 1.33 | Physiological pineal effects on female reproductive function of laboratory rats: prenatal development of pups, litter size and estrous cycle in middle age. ( Fujieda, H; Kachi, T; Suzuki, R; Tanaka, D; Tonosaki, Y; Watanabe, S, 2006) |
| "Melatonin treatment for 4 weeks restored neurogenic responses to normal values, with an associated recovery of nitrergic function and the disappearance of the capsaicin-sensitive component." | 1.33 | Melatonin treatment reverts age-related changes in Guinea pig gallbladder neuromuscular transmission and contractility. ( Camello, PJ; Camello-Almaraz, C; Gomez-Pinilla, PJ; Moreno, R; Pozo, MJ, 2006) |
| "Melatonin treatment counteracted these alterations in young and aged septic rats." | 1.33 | Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment. ( Acuña-Castroviejo, D; Escames, G; López, LC; Ortiz, F; Ros, E, 2006) |
| "Treatment with melatonin significantly decreased the MDA level both in the serum and tumor tissue." | 1.33 | Dose-dependent inhibitory effect of melatonin on carcinogenesis induced by benzo[a]pyrene in mice. ( Anisimov, VN; Plotnikova, NA; Semenchenko, AI; Vesnushkin, GM, 2006) |
| "Melatonin has been reported to have antioxidant properties in addition to its known hormonal activities." | 1.32 | Melatonin-induced reduction in age-related accumulation of oxidative damage in mice. ( Bhatia, AL; Manda, K, 2003) |
| " DHEA or DHEA-S have been administered acutely in a single intraperitoneal injection at a dosage of 50, 250, or 500 microg per animal, or on a long-term basis, i." | 1.32 | Ex vivo studies on the acute and chronic effects of DHEA and DHEA-sulfate on melatonin synthesis in young- and old-rat pineal glands. ( Djeridane, Y; Touitou, Y, 2004) |
| "Melatonin was collected by salivary samples at 2200 hours and concentrations were determined by immunoassay." | 1.32 | Declining melatonin levels and older people. How old is old? ( Graham, D; McLachlan, A, 2004) |
| "Treatment with melatonin (given with drinking water in a dose of 20 mg/liter in night hours) had no effect on the incidence of chromosome aberrations in SHR mice." | 1.31 | Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice. ( Anisimov, VN; Khavinson, VKh; Mikheev, VS; Popovich, IG; Rosenfeld, SV; Togo, EF, 2002) |
| "Contrary to the paradigm that cancer incidence increases indefinitely with age, significant data now suggest cancer incidence may markedly reduce beyond age 80 years for humans and beyond 800 days for mice, and is not inevitable." | 1.31 | A quantitative model of cellular senescence influence on cancer and longevity. ( Pompei, F; Wilson, R, 2002) |
| "Melatonin treatment reduced this increased response in acyclic rats and produced a pituitary responsiveness similar to that of young cyclic rats." | 1.31 | Effects of ageing and exogenous melatonin on pituitary responsiveness to GnRH in rats. ( Diaz, B; Diaz, E; Esquifino, AI; Pazo, D, 2000) |
| " A conclusion was drawn that caution should be exercised before melatonin is recommended for long-term administration as a geroprotector." | 1.31 | [The effect of melatonin on the indices of biological age, on longevity and on the development of spontaneous tumors in mice]. ( Anikin, IV; Anisimov, VN; Arutiunian, AV; Khavinson, VKh; Oparina, TI; Popovich, IG; Prokopenko, VM; Shtylik, AV; Solov'ev, MV; Zabezhinskiĭ, MA; Zavarzina, NIu; Zimina, OA, 2000) |
| "The melatonin onset was used as the indicator of circadian phase." | 1.31 | Effects of aging on the intrinsic circadian period of totally blind humans. ( Kendall, AR; Lewy, AJ; Sack, RL, 2001) |
| "Ten elderly residents with psychophysiological insomnia (mean age, 74." | 1.31 | Diminished melatonin secretion in the elderly caused by insufficient environmental illumination. ( Hishikawa, Y; Mishima, K; Okawa, M; Shimizu, T, 2001) |
| " Chronic administration of melatonin (0." | 1.31 | Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks. ( Kulkarni, SK; Raghavendra, V, 2001) |
| "Melatonin was found to increase IgG1 and IgM responses of aged rats when compared to controls (p = 0." | 1.31 | The effects of melatonin on humoral immune responses of young and aged rats. ( Akbulut, H; Akbulut, KG; Gönül, B, 2001) |
| "Seventy-two elders with complaints of insomnia or depression, and 30 young, healthy adults were assessed for 5-7 days at home." | 1.31 | Circadian abnormalities in older adults. ( Elliott, JA; Klauber, MR; Kripke, DF; Youngstedt, SD, 2001) |
| "Melatonin was undetectable in milk in the light (< 21 pM), but increased rapidly 2-4 h after dark to peak at 357 +/- 66 pM at mid-dark." | 1.31 | Melatonin in rat milk and the likelihood of its role in postnatal maternal entrainment of rhythms. ( Kennaway, DJ; Rowe, SA, 2002) |
| "Melatonin treatment did not alter this decrease." | 1.31 | Age differences in neurokinin A and substance P from the hypothalamus, pituitary, pineal gland, and striatum of the rat. Effect of exogenous melatonin. ( Debeljuk, L; Díaz, B; Díaz, E; Fernández, C, 2002) |
| "Melatonin is a hormone secreted by the pineal gland, the releasing stimulus of which is darkness." | 1.30 | [Juvenile hormones, reality or myth?]. ( Vermeulen, A, 1997) |
| "Melatonin (MLT) treatment in vivo has been shown to have immunomodulatory and anti-immunosenescent effects in the mouse model." | 1.30 | In vitro effects of melatonin on mitogen-induced lymphocyte proliferation and cytokine expression in young and old rats. ( Harris, MD; Pahlavani, MA, 1997) |
| "Melatonin treatment increased O2 consumption in mice injected with saline but suppressed the increased metabolic rate associated with an immune response in KLH-injected animals." | 1.30 | Metabolic costs of mounting an antigen-stimulated immune response in adult and aged C57BL/6J mice. ( Chefer, V; Demas, GE; Nelson, RJ; Talan, MI, 1997) |
| "68 women were diagnosed with endometrial cancer, 70 patients had abnormal bleeding." | 1.30 | A significant correlation between melatonin deficiency and endometrial cancer. ( Grin, W; Grünberger, W, 1998) |
| "The melatonin levels were lowest in November, higher in February, and even higher in April in both male and female volunteers." | 1.29 | Seasonal changes in the levels of antidiuretic hormone and melatonin in the elderly. ( Aberg, H; Asplund, R; Wetterberg, L, 1995) |
| " The results of pharmacokinetic parameters calculated from serum melatonin showed no significant gender differences in adults." | 1.29 | Pharmacokinetics of melatonin in human sexual maturation. ( Cavallo, A; Ritschel, WA, 1996) |
| "Treatment with melatonin increased the incidence of heifers pubertal by the second observation date (P less than ." | 1.28 | Effects of melatonin treatment on the attainment of puberty in heifers. ( Inskeep, EK; Tortonese, DJ, 1992) |
| "Mean melatonin peak was 153." | 1.28 | Plasma melatonin rhythm in normal puberty: interactions of age and pubertal stages. ( Cavallo, A, 1992) |
| "Melatonin is known to inhibit GnRH-stimulated LH release from neonatal rat pituitary cells." | 1.28 | Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells. ( Klein, DC; Vanecek, J, 1992) |
| "Melatonin values were higher in patients aged under 10 years than over 20 years in the absence of meningitis or tumor in the pineal region." | 1.28 | [The studies of melatonin values in the cerebrospinal fluid of hydrocephalic patients]. ( Eghwrudjakpor, PO; Kurisaka, M; Miyake, H; Mori, K, 1991) |
| "Melatonin was significantly more potent when applied at the end of the light period as compared with the first half of the day." | 1.28 | Developmental changes and daily rhythm in melatonin-induced inhibition of 3',5'-cyclic AMP accumulation in the rat pituitary. ( Vanecek, J; Vollrath, L, 1990) |
| "Melatonin in tissues was extracted, identified, and determined by gas chromatography-mass spectrometry (GC-MS) and/or radioimmunoassay." | 1.28 | Fluctuation of blood melatonin concentrations with age: result of changes in pineal melatonin secretion, body growth, and aging. ( Brown, GM; Hong, GX; Pang, SF; Tang, PL; Tsang, CW; Yip, PC, 1990) |
| "Melatonin was detectable in plasma by 5 days postnatally and reached adult levels at 21 days." | 1.28 | Ontogenesis of pineal thyroxine 5'-deiodinase activity and plasma melatonin concentration in the rat. ( Greer, MA; Greer, SE; Lewy, AJ; McAdams, S; Murakami, M, 1989) |
| "Melatonin pretreatment blocked GRF-induced increment of GH in rats." | 1.27 | The pineal gland in relation to growth and development in children. ( Gupta, D, 1986) |
| "Melatonin production was estimated by measuring the overnight excretion of its major urinary metabolite, 6-hydroxymelatonin." | 1.27 | Human melatonin production decreases with age. ( Erb, DL; Lewy, AJ; Sack, RL; Singer, CM; Vollmer, WM, 1986) |
| "When melatonin rhythms were monitored in 3 mares and their foals housed in open pens exposed to natural lighting, significant time trends in melatonin concentrations were observed in mares when the foals were aged 1-3, 4-6 and 7-11 weeks, but foals did not display significant times trends in melatonin until they were 7-11 weeks old." | 1.26 | Melatonin rhythms in Pony mares and foals. ( Berglund, LA; Grubaugh, W; Kilmer, DM; McDowell, KJ; Peck, LS; Sharp, DC, 1982) |
| "Melatonin excretion was determined in 88 boys and 82 girls 9-16 yr of age, in 16 adult males, and throughout the menstrual cycle of one adult female." | 1.26 | Melatonin excretion in normal males and females: increase during puberty. ( Penny, R, 1982) |
| "Melatonin values were low in pineal glands of all animals killed at 1600 h in light." | 1.26 | Age-associated reduction in nocturnal pineal melatonin levels in female rats. ( Craft, CM; Johnson, JE; King, TS; Reiter, RJ; Richardson, BA; Vaughan, GM; Vaughan, MK, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 85 (10.34) | 18.7374 |
| 1990's | 205 (24.94) | 18.2507 |
| 2000's | 274 (33.33) | 29.6817 |
| 2010's | 201 (24.45) | 24.3611 |
| 2020's | 57 (6.93) | 2.80 |
| Authors | Studies |
|---|---|
| Baeeri, M | 1 |
| Didari, T | 1 |
| Khalid, M | 1 |
| Mohammadi-Nejad, S | 1 |
| Daghighi, SM | 1 |
| Farhadi, R | 1 |
| Rahimifard, M | 1 |
| Bayrami, Z | 1 |
| Haghi-Aminjan, H | 1 |
| Foroumadi, R | 1 |
| Gholami, M | 1 |
| Abdollahi, M | 1 |
| Tchekalarova, J | 2 |
| Hrischev, P | 1 |
| Ivanova, P | 1 |
| Boyadjiev, N | 1 |
| Georgieva, K | 1 |
| Atayik, MC | 1 |
| Çakatay, U | 2 |
| Telegina, DV | 1 |
| Antonenko, AK | 1 |
| Fursova, AZ | 1 |
| Kolosova, NG | 2 |
| Fan, R | 1 |
| Peng, X | 1 |
| Xie, L | 1 |
| Dong, K | 1 |
| Ma, D | 1 |
| Xu, W | 1 |
| Shi, X | 1 |
| Zhang, S | 1 |
| Chen, J | 1 |
| Yu, X | 1 |
| Yang, Y | 2 |
| Cachán-Vega, C | 1 |
| Vega-Naredo, I | 4 |
| Potes, Y | 1 |
| Bermejo-Millo, JC | 1 |
| Rubio-González, A | 1 |
| García-González, C | 1 |
| Antuña, E | 1 |
| Bermúdez, M | 1 |
| Gutiérrez-Rodríguez, J | 1 |
| Boga, JA | 3 |
| Coto-Montes, A | 6 |
| Caballero, B | 4 |
| Verma, AK | 2 |
| Singh, S | 2 |
| Rizvi, SI | 2 |
| Li, F | 3 |
| Lun, D | 1 |
| Liu, D | 2 |
| Jia, Z | 1 |
| Zhu, Z | 1 |
| Liu, Z | 1 |
| Li, X | 4 |
| Tzoneva, R | 1 |
| Reiter, RJ | 59 |
| Sharma, R | 3 |
| Cucielo, MS | 1 |
| Tan, DX | 15 |
| Rosales-Corral, S | 4 |
| Gancitano, G | 1 |
| de Almeida Chuffa, LG | 1 |
| Zhukova, OV | 1 |
| Vinogradova, IA | 14 |
| Goransky, AI | 1 |
| Lee, WY | 1 |
| Sim, HW | 1 |
| Park, HJ | 1 |
| Eto, T | 1 |
| Higuchi, S | 2 |
| Suzen, S | 1 |
| Saso, L | 1 |
| Al-Rawaf, HA | 1 |
| Gabr, SA | 1 |
| Iqbal, A | 1 |
| Alghadir, AH | 1 |
| Burns, BR | 1 |
| Gao, WT | 1 |
| Liu, JX | 1 |
| Wang, DH | 1 |
| Sun, HJ | 1 |
| Zhang, XY | 1 |
| He, Y | 1 |
| Gao, M | 1 |
| Yang, W | 2 |
| Sun, S | 1 |
| Wang, Q | 2 |
| Gu, L | 1 |
| Samra, T | 1 |
| Gomez-Gomez, T | 1 |
| Linowiecka, K | 1 |
| Akhundlu, A | 1 |
| Lopez de Mendoza, G | 1 |
| Gompels, M | 1 |
| Lee, WW | 1 |
| Gherardini, J | 1 |
| Chéret, J | 1 |
| Paus, R | 1 |
| Hosseini, L | 2 |
| Farokhi-Sisakht, F | 1 |
| Badalzadeh, R | 2 |
| Khabbaz, A | 1 |
| Mahmoudi, J | 1 |
| Sadigh-Eteghad, S | 1 |
| Gunata, M | 1 |
| Parlakpinar, H | 3 |
| Acet, HA | 1 |
| Scuderi, L | 1 |
| Davinelli, S | 1 |
| Iodice, CM | 1 |
| Bartollino, S | 1 |
| Scapagnini, G | 1 |
| Costagliola, C | 1 |
| Scuderi, G | 1 |
| Aiello, A | 1 |
| Accardi, G | 1 |
| Xu, F | 3 |
| Zhong, JY | 1 |
| Lin, X | 1 |
| Shan, SK | 1 |
| Guo, B | 1 |
| Zheng, MH | 1 |
| Wang, Y | 2 |
| Cui, RR | 1 |
| Wu, F | 1 |
| Zhou, E | 1 |
| Liao, XB | 1 |
| Liu, YS | 1 |
| Yuan, LQ | 1 |
| Li, C | 2 |
| He, X | 1 |
| Huang, Z | 1 |
| Han, L | 1 |
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| Lang, U | 4 |
| Aubert, ML | 5 |
| Rivest, RW | 4 |
| Vinas-Bradtke, JC | 1 |
| Sizonenko, PC | 5 |
| Pang, SF | 8 |
| Tang, F | 2 |
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| Lemaitre, BJ | 1 |
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| Rissman, EF | 1 |
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| Weitzman, ED | 1 |
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| Asplund, R | 1 |
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| Soldani, R | 3 |
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| Migliorati, G | 1 |
| Nescis, T | 2 |
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| Solerte, SB | 4 |
| McLeod, SD | 1 |
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| Kosar, E | 1 |
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| Bulian, D | 6 |
| Piantanelli, L | 2 |
| Bryden, MM | 2 |
| Buckendahl, P | 1 |
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| Yuwiler, A | 3 |
| Menendez-Pelaez, A | 2 |
| Chen, LD | 2 |
| Saarela, S | 1 |
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| Tibaldi, A | 4 |
| Fabris, N | 6 |
| Caroleo, MC | 1 |
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| Humbert, W | 1 |
| Lesnikov, VA | 2 |
| Kloeden, PE | 2 |
| Rössler, R | 2 |
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| Bartsch, C | 1 |
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| Mecke, D | 1 |
| Lippert, TH | 1 |
| Muzzioli, M | 2 |
| Regelson, W | 2 |
| Grad, BR | 2 |
| Rozencwaig, R | 2 |
| Słowińska-Klencka, D | 1 |
| Lewiński, A | 1 |
| Waldhauser, F | 5 |
| Ehrhart, B | 1 |
| Förster, E | 1 |
| Whealin, JM | 1 |
| Burwell, RD | 1 |
| Gallagher, M | 1 |
| Davis, FC | 2 |
| Carneiro, RC | 1 |
| Pereira, EP | 1 |
| Markus, RP | 2 |
| Murialdo, G | 1 |
| Costelli, P | 1 |
| Fonzi, S | 1 |
| Parodi, C | 1 |
| Torre, F | 1 |
| Cenacchi, T | 1 |
| Polleri, A | 1 |
| Kennedy, SH | 1 |
| Ford, CG | 1 |
| Ralevski, E | 1 |
| Ryan, KD | 2 |
| Volk, EA | 1 |
| Lenz, SP | 1 |
| Izui, S | 1 |
| Benediktsson, H | 1 |
| Hart, DA | 1 |
| Castillo-Romero, JL | 1 |
| Escamaes, G | 1 |
| Vives, F | 1 |
| Cavallo, A | 4 |
| Ritschel, WA | 1 |
| Arendt, J | 4 |
| García-Patterson, A | 1 |
| Puig-Domingo, M | 1 |
| Webb, SM | 1 |
| Pablos, MI | 1 |
| Agapito, TT | 1 |
| Martin-Du Pan, R | 1 |
| Mauron, C | 1 |
| Exposito, I | 1 |
| Mora, F | 1 |
| Oaknin, S | 1 |
| Uría, H | 1 |
| Kotler, M | 1 |
| Antolín, I | 1 |
| Rodriguez, C | 1 |
| Vakkuri, O | 2 |
| Kivelä, A | 1 |
| Leppäluoto, J | 2 |
| Kauppila, A | 1 |
| Nilsson, PM | 1 |
| Provinciali, M | 3 |
| Di Stefano, G | 2 |
| Molina Carballo, A | 1 |
| Muñoz Hoyos, A | 1 |
| Uberos Fernández, J | 1 |
| Molina Font, JA | 1 |
| Stoll, S | 1 |
| Müller, WE | 1 |
| Prendergast, BJ | 1 |
| Kelly, KK | 1 |
| Molina-Carballo, A | 1 |
| Muñoz-Hoyos, A | 1 |
| Martin-García, JA | 1 |
| Uberos-Fernández, J | 1 |
| Rodriguez-Cabezas, T | 1 |
| Limanowski, A | 1 |
| Miskowiak, B | 1 |
| Otulakowski, B | 1 |
| Young, SN | 2 |
| Locatelli, M | 2 |
| Balza, G | 2 |
| Battegazzore, C | 1 |
| Cuzzoni, G | 2 |
| Haus, E | 2 |
| Brzezinski, A | 2 |
| Dolan, LM | 1 |
| Sandyk, R | 4 |
| Selmaoui, B | 2 |
| San Martin, M | 1 |
| McCarty, MF | 1 |
| Gattei, G | 1 |
| Maierna, GG | 1 |
| Butler, RN | 1 |
| Kendler, BS | 1 |
| Tabandeh, H | 1 |
| Bird, AC | 1 |
| Defrance, R | 1 |
| Shomali, ME | 1 |
| Parr, T | 1 |
| Myl'nikov, SV | 1 |
| Oparina, TI | 3 |
| Vermeulen, A | 1 |
| Vitiello, MV | 1 |
| Diekman, MA | 1 |
| Arthington, JA | 1 |
| Clapper, JA | 1 |
| Green, ML | 1 |
| Pahlavani, MA | 2 |
| Harris, MD | 1 |
| Pozdeev, NV | 1 |
| Etingof, RN | 1 |
| Stronati, S | 1 |
| Li, S | 1 |
| Givalois, L | 1 |
| Pelletier, G | 1 |
| Arangino, S | 1 |
| Malmusi, S | 1 |
| Longo, M | 1 |
| Volpe, A | 1 |
| Pappolla, MA | 2 |
| Demas, GE | 1 |
| Chefer, V | 1 |
| Talan, MI | 1 |
| Puigdevall Gallego, V | 1 |
| Laudo Pardos, C | 1 |
| Pang, CS | 1 |
| Ng, KW | 1 |
| Guardiola-Lemaitre, B | 1 |
| Djamgoz, MB | 1 |
| Hankins, MW | 1 |
| Hirano, J | 1 |
| Masana, MI | 1 |
| Dubocovich, ML | 1 |
| Langer, M | 1 |
| Hartmann, J | 1 |
| Turkof, H | 1 |
| Nohl, H | 1 |
| Staniek, K | 1 |
| Watson, RR | 3 |
| Baskett, JJ | 3 |
| Cockrem, JF | 2 |
| Antunovich, TA | 1 |
| Grin, W | 1 |
| Grünberger, W | 1 |
| Elliot, JA | 1 |
| Smith, JS | 1 |
| Zhang, Z | 1 |
| Inserra, PF | 1 |
| Liang, B | 1 |
| Ardestani, SK | 1 |
| Elliott, KK | 1 |
| Molitor, M | 1 |
| Bornkessel, B | 1 |
| Brusco, LI | 3 |
| García Bonacho, M | 1 |
| Colmenero Urquijo, MD | 1 |
| Marín Fernández, B | 2 |
| Cipriano, K | 1 |
| Olivieri, F | 1 |
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| Perfetto, F | 2 |
| Atre, D | 1 |
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| Aldegunde, M | 1 |
| Garfinkel, D | 1 |
| Berner, YN | 1 |
| Dkhissi, O | 1 |
| Chanut, E | 1 |
| Versaux-Botteri, C | 1 |
| Trouvin, JH | 1 |
| Repérant, J | 1 |
| Nguyen-Legros, J | 1 |
| Greene, J | 1 |
| García-Bonacho, M | 1 |
| Luboshitzky, R | 2 |
| Yanai, D | 1 |
| Shen-Orr, Z | 2 |
| Israeli, E | 1 |
| Herer, P | 2 |
| Lavie, P | 2 |
| Wilkinson, CW | 1 |
| Gonca Akbulut, K | 1 |
| Gönü l, B | 1 |
| Riel, E | 1 |
| Shanahan, TL | 3 |
| Izmaĭlov, DM | 1 |
| Obukhova, LK | 2 |
| Izmaylov, DM | 1 |
| Bergiannaki, JD | 1 |
| Paparrigopoulos, T | 1 |
| von Knorring, L | 1 |
| Eberhard, G | 1 |
| Bratlid, T | 1 |
| Hall, EF | 1 |
| Grosse, J | 1 |
| Hayashi, K | 2 |
| Gilbert, SS | 1 |
| van den Heuvel, CJ | 1 |
| Dawson, D | 3 |
| Brown, EN | 1 |
| Mitchell, JF | 1 |
| Rimmer, DW | 2 |
| Ronda, JM | 1 |
| Silva, EJ | 1 |
| Allan, JS | 1 |
| Emens, JS | 1 |
| Kronauer, RE | 1 |
| Araghi-Niknam, M | 1 |
| Lane, L | 1 |
| Moore, RY | 1 |
| Nathan, PJ | 1 |
| Burrows, GD | 1 |
| Norman, TR | 1 |
| Benot, S | 1 |
| Goberna, R | 1 |
| Garcia-Mauriño, S | 1 |
| Osuna, C | 1 |
| Zhang, QZ | 2 |
| Zhang, JT | 2 |
| Morioka, N | 3 |
| Ziegelhöffer, A | 1 |
| Lushington, K | 2 |
| Lack, L | 2 |
| van den Heuvel, C | 1 |
| Rogers, N | 1 |
| Daniels, JE | 1 |
| Klerman, EB | 2 |
| Tan, D | 1 |
| Kim, SJ | 1 |
| Qi, W | 1 |
| Cabrera, JC | 1 |
| El-Sokkary, G | 1 |
| Rouvier-Garay, V | 1 |
| Shukitt-Hale, B | 1 |
| Smith, DE | 1 |
| Meydani, M | 1 |
| Joseph, JA | 1 |
| Pazo Vinuesa, D | 2 |
| Esquifino Parras, A | 1 |
| Yu, BP | 2 |
| Hermann, M | 1 |
| Berger, P | 1 |
| Castrillón, PO | 2 |
| Marín, B | 2 |
| Fauteck, JD | 1 |
| Dittgen, M | 1 |
| Farker, K | 1 |
| Hoffmann, A | 1 |
| Hoffmann, H | 1 |
| Wittkowski, W | 1 |
| Esquifino Parras, AI | 1 |
| Illnerová, H | 2 |
| Trávnícková, Z | 1 |
| Jác, M | 1 |
| Sumová, A | 1 |
| Shibata, S | 1 |
| Asai, M | 1 |
| Oshima, I | 1 |
| Ikeda, M | 1 |
| Yoshioka, T | 1 |
| Gauer, F | 1 |
| Schuster, C | 1 |
| Poirel, VJ | 1 |
| Masson-Pevet, M | 1 |
| Turek, FW | 6 |
| Zee, P | 1 |
| Van Reeth, O | 3 |
| Meredith, S | 1 |
| Jackson, K | 1 |
| Dudenhoeffer, G | 1 |
| Graham, L | 1 |
| Epple, J | 1 |
| Qian, SZ | 1 |
| Cheng Xu, Y | 1 |
| Wurtman, RJ | 1 |
| Yin, D | 1 |
| Pazo, D | 1 |
| Laberge, L | 1 |
| Lespérance, P | 1 |
| Lambert, C | 1 |
| Vitaro, F | 1 |
| Tremblay, RE | 1 |
| Montplaisi, J | 1 |
| Li, JC | 1 |
| Zavarzina, NIu | 1 |
| Anikin, IV | 1 |
| Zimina, OA | 2 |
| Solov'ev, MV | 1 |
| Shtylik, AV | 1 |
| Prokopenko, VM | 2 |
| Cernuda-Cernuda, R | 1 |
| Huerta, JJ | 1 |
| Muñoz Llamosas, M | 1 |
| Alvarez-Uría, M | 1 |
| García-Fernández, JM | 1 |
| Kennaway, D | 1 |
| Arce, A | 1 |
| Esquifino, A | 1 |
| Weibel, L | 2 |
| Mocaer, E | 2 |
| Girotti, L | 1 |
| Lago, M | 1 |
| Ianovsky, O | 1 |
| Carbajales, J | 1 |
| Elizari, MV | 1 |
| Ramsey, JJ | 1 |
| Colman, RJ | 1 |
| Binkley, NC | 1 |
| Christensen, JD | 1 |
| Gresl, TA | 1 |
| Kemnitz, JW | 1 |
| Weindruch, R | 1 |
| Arcaini, A | 1 |
| Gornati, R | 1 |
| Pelanconi, L | 1 |
| Fourtillan, JB | 1 |
| Brisson, AM | 1 |
| Fourtillan, M | 1 |
| Ingrand, I | 1 |
| Decourt, JP | 1 |
| Girault, J | 1 |
| Recabarren, SE | 1 |
| Lobos, A | 1 |
| Cendoyya, E | 1 |
| Correa, C | 1 |
| Rudolph, I | 1 |
| Burioka, N | 1 |
| Bakken, EE | 1 |
| Kendall, AR | 1 |
| Lewy, AJ | 3 |
| Sack, RL | 2 |
| Okawa, M | 1 |
| Gong, YS | 1 |
| Olivares, E | 1 |
| Maccari, S | 1 |
| Raghavendra, V | 1 |
| Kulkarni, SK | 1 |
| Arutjunyan, AV | 2 |
| Khavinson, VK | 1 |
| Inoh, H | 1 |
| Kawakami, N | 1 |
| Matsuyama, Y | 1 |
| Aoki, T | 1 |
| Kanemura, T | 1 |
| Natsume, N | 1 |
| Iwata, H | 1 |
| van Rensburg, SJ | 1 |
| Daniels, WM | 1 |
| van Zyl, JM | 1 |
| Taljaard, JJ | 1 |
| Wood, PC | 1 |
| Broad, JB | 1 |
| Duncan, JR | 1 |
| English, J | 2 |
| Horton, TH | 5 |
| Hira, Y | 1 |
| Sakai, Y | 1 |
| Matsushima, S | 1 |
| Lesnikov, V | 1 |
| Lesnikov, M | 1 |
| Zavarzina, NY | 1 |
| Shtylick, AV | 1 |
| Mikhalski, AI | 1 |
| Yashin, AI | 1 |
| Andorn, AC | 1 |
| Oxenkrug, G | 2 |
| Requintina, P | 1 |
| Bachurin, S | 1 |
| Tzischichinsky, O | 1 |
| Maldonado, M | 1 |
| Mitton, DR | 1 |
| Larsen, SA | 1 |
| Khavinson, V | 1 |
| Goncharova, N | 1 |
| Lapin, B | 1 |
| Khavinson, BK | 1 |
| Klauber, MR | 1 |
| Popuichiev, V | 1 |
| Mikhina, L | 1 |
| Anisimov, V | 1 |
| Yuzhakov, V | 1 |
| Konovalov, S | 1 |
| Pogudina, N | 1 |
| Franceschi, C | 1 |
| Rossolini, G | 1 |
| Zaia, A | 1 |
| Kvetnaia, T | 1 |
| Hernandez-Yago, J | 1 |
| Blesa, JR | 1 |
| Aujard, F | 1 |
| Dkhissi-Benyahya, O | 1 |
| Fournier, I | 1 |
| Schilling, A | 1 |
| Perret, M | 1 |
| Payão, SL | 1 |
| de Carvalho, CV | 1 |
| da Silva, ER | 1 |
| Lopes, C | 1 |
| Winter, LM | 1 |
| Smith, MA | 1 |
| Yang, YE | 1 |
| Walsh, TJ | 1 |
| Gie, YW | 1 |
| Somova, EV | 1 |
| Kolodub, FA | 1 |
| Sakamoto, K | 1 |
| Oishi, K | 1 |
| Ishida, N | 1 |
| Lewis, PD | 1 |
| Perry, GC | 1 |
| Morris, TR | 1 |
| Zhang, Q | 1 |
| Vitalis, T | 1 |
| Fouquet, C | 1 |
| Alvarez, C | 1 |
| Seif, I | 1 |
| Price, D | 1 |
| Gaspar, P | 1 |
| Cases, O | 1 |
| Rowe, SA | 1 |
| Vargas, DA | 1 |
| Evans, TR | 1 |
| Shu, JH | 1 |
| Nelson, JF | 1 |
| Cano, P | 1 |
| Chacon, F | 1 |
| Reyes Toso, CF | 1 |
| Bonilla, E | 1 |
| Medina-Leendertz, S | 1 |
| Díaz, S | 1 |
| Hendrick, JC | 1 |
| Crasson, M | 1 |
| Hagelstein, MT | 1 |
| Bruls, E | 1 |
| Kolker, DE | 1 |
| Losee Olson, S | 1 |
| Dutton-Boilek, J | 1 |
| Bennett, KM | 1 |
| Wallen, EP | 1 |
| Pallotti, S | 1 |
| Nordio, M | 1 |
| Giuliano, S | 1 |
| El-Sawi, MR | 1 |
| Uz, T | 1 |
| Qu, T | 1 |
| Manev, H | 1 |
| Anand, S | 1 |
| Losee-Olson, S | 1 |
| Burkhardt, S | 1 |
| Seils, LK | 1 |
| Kayumov, L | 1 |
| Ralph, MR | 1 |
| Lowe, A | 1 |
| Moller, H | 1 |
| Golubev, AG | 1 |
| Purtill, RA | 1 |
| Grota, LJ | 2 |
| Sattler, C | 1 |
| Gauthier, S | 1 |
| Tsui, H | 1 |
| Frowein, A | 1 |
| Lapin, V | 1 |
| Butcher, RE | 1 |
| Vorhees, CV | 1 |
| Kindt, CW | 1 |
| Kazmaier-Novak, KJ | 1 |
| Berry, HK | 1 |
| Panke, ES | 1 |
| Panke, TW | 1 |
| Laitinen, JT | 1 |
| Saavedra, JM | 1 |
| Chong, NW | 1 |
| Sugden, D | 2 |
| Korneva, EA | 1 |
| Dall'ara, A | 3 |
| Inskeep, EK | 1 |
| Evans, BK | 1 |
| Mason, R | 1 |
| Wilson, VG | 1 |
| Trentini, GP | 2 |
| Genazzani, AR | 1 |
| Criscuolo, M | 2 |
| Petraglia, F | 1 |
| De Gaetani, C | 2 |
| Ficarra, G | 1 |
| Bidzinska, B | 1 |
| Migaldi, M | 1 |
| Genazzani, AD | 1 |
| Härmä, MI | 1 |
| Hakola, T | 1 |
| Laitinen, J | 1 |
| Stamp, GE | 1 |
| Goble, FC | 1 |
| Nonaka, KO | 1 |
| McIntyre, IM | 2 |
| Duffy, JD | 1 |
| Todd, MA | 1 |
| Scaccianoce, S | 1 |
| Alemà, S | 1 |
| Cigliana, G | 1 |
| Navarra, D | 1 |
| Ramacci, MT | 1 |
| Angelucci, L | 1 |
| Pedrinis, E | 1 |
| Armstrong, SM | 1 |
| Redman, JR | 1 |
| Chan, YS | 1 |
| Cheung, YM | 1 |
| Boepple, PA | 1 |
| Schemper, M | 2 |
| Mansfield, MJ | 1 |
| Crowley, WF | 1 |
| Hayashi, T | 1 |
| Anegawa, S | 1 |
| Torigoe, R | 1 |
| Kurisaka, M | 1 |
| Miyake, H | 1 |
| Eghwrudjakpor, PO | 1 |
| Mori, K | 1 |
| Anninos, PA | 1 |
| Tsagas, N | 1 |
| Kuchel, GA | 1 |
| Zigmond, RE | 1 |
| Vollrath, L | 2 |
| Dawson, KA | 1 |
| Vivien-Roels, B | 1 |
| Sparks, DL | 1 |
| Hunsaker, JC | 1 |
| Ravid, D | 1 |
| Little, GJ | 1 |
| Yi, CX | 1 |
| Buresová, M | 1 |
| Benesová, O | 1 |
| Maurizi, CP | 1 |
| Tsang, CW | 1 |
| Hong, GX | 1 |
| Yip, PC | 1 |
| Bojkowski, CJ | 1 |
| Currie, JE | 1 |
| Wright, J | 1 |
| Boulter, PS | 1 |
| Wever, RA | 1 |
| Hastings, MH | 1 |
| Walker, AP | 1 |
| Powers, JB | 1 |
| Hutchison, J | 1 |
| Steel, EA | 1 |
| Herbert, J | 1 |
| Hadjiconstantinou, M | 1 |
| Donham, RS | 1 |
| Souêtre, E | 1 |
| Salvati, E | 1 |
| Krebs, B | 1 |
| Belugou, JL | 1 |
| Darcourt, G | 1 |
| Ray, SL | 1 |
| Creyaufmiller, N | 1 |
| Murakami, M | 1 |
| Greer, MA | 1 |
| Greer, SE | 1 |
| McAdams, S | 1 |
| Dax, EM | 1 |
| Laudon, M | 1 |
| Ochoa, J | 1 |
| Sharma, M | 1 |
| Palacios-Bois, J | 1 |
| Iskandar, H | 1 |
| Thakur, M | 1 |
| Quirion, R | 1 |
| Thomas, DR | 1 |
| Miles, A | 1 |
| Gupta, D | 3 |
| Winiger, BP | 1 |
| Villanúa, MA | 1 |
| Agrasal, C | 1 |
| Jaconi, ME | 1 |
| Gruaz, N | 1 |
| Bhattacharya, SK | 1 |
| Glover, V | 1 |
| McIntyre, I | 1 |
| Sandler, M | 1 |
| Mahata, SK | 1 |
| Mandal, A | 1 |
| Ghosh, A | 1 |
| Hurlbut, EC | 1 |
| Tannenbaum, MG | 1 |
| Troiani, ME | 1 |
| Weiszenbacher, G | 1 |
| Tatzer, E | 1 |
| Gisinger, B | 1 |
| Waldhauser, M | 1 |
| Frisch, H | 1 |
| Young, IM | 1 |
| Francis, PL | 1 |
| Leone, AM | 1 |
| Stovell, P | 1 |
| Silman, RE | 1 |
| Conti, A | 1 |
| Stanczyk, F | 1 |
| Goebelsmann, U | 1 |
| Steger, H | 1 |
| Catala, MD | 1 |
| Timiras, PS | 1 |
| Foster, DL | 1 |
| Karsch, FJ | 1 |
| Olster, DH | 1 |
| Pulido, O | 1 |
| Clifford, J | 1 |
| Reuss, S | 1 |
| Erb, DL | 1 |
| Vollmer, WM | 1 |
| Singer, CM | 1 |
| Hariharasubramanian, N | 1 |
| Pilapil, C | 1 |
| Isaac, I | 1 |
| Attanasio, A | 1 |
| Borrelli, P | 1 |
| Gross, R | 1 |
| Oishi, T | 1 |
| Lauber, JK | 1 |
| Ellis, LC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Randomized Controlled Trial of the Efficacy of Melatonin in the Prophylaxis of SARS-coronavirus-2 Infection Among High Risk Contacts.[NCT04353128] | Phase 2/Phase 3 | 450 participants (Actual) | Interventional | 2020-04-20 | Completed | ||
| Melatonin and Essential Arterial Hypertension[NCT05257291] | Phase 2 | 23 participants (Actual) | Interventional | 2018-02-02 | Active, not recruiting | ||
| A Triple Blinded Randomized Controlled Trial of Oral Melatonin in Elevated Blood Pressure Individual (MRCTEBP)[NCT03764020] | Phase 3 | 320 participants (Anticipated) | Interventional | 2019-06-01 | Not yet recruiting | ||
| The Light Heart Study: Daily Light Box Use for Depressive Symptoms in Patients With Stage B Heart Failure[NCT02691000] | 122 participants (Anticipated) | Interventional | 2015-09-30 | Recruiting | |||
| High Cortisol Levels as a Risk Factor for Depression in the Elderly and the Effect of Bright Light Treatment on Mood, Sleep-Wake Pattern and Self-Sufficiency[NCT00332670] | Phase 2/Phase 3 | 89 participants (Actual) | Interventional | 2003-01-31 | Terminated (stopped due to End of research time, time-resources) | ||
| Bright Light Therapy Efficacy for Depressive Symptoms Following Cardiac Surgery or Acute Coronary Syndrome: Pilot Trial[NCT02621567] | Phase 4 | 15 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial.[NCT03368430] | Phase 4 | 74 participants (Actual) | Interventional | 2016-07-04 | Completed | ||
| Effects of Shift Work on Health: Assessment of Sleep Quality, Motor Control and Cardiovascular Risk.[NCT03453398] | 71 participants (Actual) | Interventional | 2018-01-23 | Completed | |||
| The Role of the Circadian System in Neurological Sleep-wake Disorders: Assessment of Circadian and Homeostatic Sleep-wake Regulation and Vigilance With a Poly-nap Protocol[NCT03356938] | 36 participants (Actual) | Interventional | 2017-11-28 | Completed | |||
| Efficacy of New Lenses in Abolishing Photoparoxysmal Responses in Paediatric Patients With Photosensitive Epilepsy (PSE)[NCT04076410] | 76 participants (Anticipated) | Interventional | 2021-02-20 | Recruiting | |||
| Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes: Pilot Study[NCT03848533] | Phase 2 | 42 participants (Anticipated) | Interventional | 2019-08-22 | Recruiting | ||
| Testosterone Supplementation and Exercise in Elderly Men[NCT00112151] | Phase 2 | 167 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| [NCT00005401] | 0 participants | Observational | 1995-08-31 | Completed | |||
| Sleep, Aging, and Circadian Rhythm Disorders[NCT00506428] | 25 participants (Anticipated) | Interventional | 2006-12-31 | Recruiting | |||
| Disrupted Sleep in the Elderly: Light Exposure Studies[NCT00427323] | 60 participants (Anticipated) | Interventional | 2006-06-30 | Suspended (stopped due to recruitment has been put on hold until a future date) | |||
| Characterization of Endogenous Melatonin Profiles in Children With Autism Spectrum Disorder.[NCT00691080] | 58 participants (Actual) | Observational | 2007-09-30 | Completed | |||
| Effects of Bright Light Treatment on Daytime Sleepiness and Nocturnal Sleep in Patients With Parkinson's Disease[NCT01338649] | 27 participants (Actual) | Interventional | 2007-11-30 | Completed | |||
| The Role of Circadian Rhythm in the Effect of Sleep Intervention on Obesity Prevention in Early Childhood[NCT05159141] | 480 participants (Anticipated) | Interventional | 2022-01-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total change in Fat free mass (kg) as evaluated by DXA (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | kg (Mean) |
|---|---|
| Placebo + No PRT | 0.1 |
| Placebo + PRT | 0.4 |
| Any T + No PRT | 1.0 |
| Any T + PRT | 2.1 |
Total change in Fat mass (kg) as evaluated by DXA (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | kg (Mean) |
|---|---|
| Placebo + No PRT | 0.7 |
| Placebo + PRT | -0.6 |
| Any T + No PRT | -1.0 |
| Any T + PRT | -1.8 |
The maximal weight a participant could lift once [1-repetition maximum, 1-RM] was assessed at baseline and 12 months. The average of the difference from baseline in 3 lower-body 1-RM measures (knee extension, knee flexion, and seated leg press)) are represented. (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | kg (Mean) |
|---|---|
| Placebo + No PRT | 9.4 |
| Placebo + PRT | 27.0 |
| Any T + No PRT | 10.5 |
| Any T + PRT | 28.0 |
Continuous-scale physical function performance test (CS-PFP) which comprises 15 everyday tasks requiring upper and lower body strength and flexibility, balance, coordination and endurance. The CS-PFP was developed to measure performance in higher functioning adults with minimal floor or ceiling effects, and is valid, reliable and sensitive to change. Total and domain scores are scaled from 0 to 100, with higher scores indicating better function. (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo + No PRT | 3.1 |
| Placebo + PRT | 3.6 |
| Any T + No PRT | 0.8 |
| Any T + PRT | 3.3 |
Leg extensor power was evaluated using a Nottingham leg extensor power rig (watts). (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | Watts (Mean) |
|---|---|
| Placebo + No PRT | 4.5 |
| Placebo + PRT | 24.3 |
| Any T + No PRT | 0.8 |
| Any T + PRT | 5.1 |
The maximal weight a participant could lift once (1-repetition maximum, 1-RM) was assessed at baseline and 12 months. The average of the difference from baseline in 4 upper-body 1-RM measures (bench press,incline press, overhead pull-down, and seated row) are represented. (NCT00112151)
Timeframe: Baseline and 12 months
| Intervention | kg (Mean) |
|---|---|
| Placebo + No PRT | 4.3 |
| Placebo + PRT | 25.5 |
| Any T + No PRT | 7.8 |
| Any T + PRT | 24.3 |
ESS score range is 0-24; lower ESS scores indicate less daytime sleepiness; higher ESS scores indicate more severe sleepiness ESS will be taken and compared at screening and week 4 visits between the bright light exposure and dim-red light exposure groups. (NCT01338649)
Timeframe: baseline and 4 weeks
| Intervention | score (Mean) |
|---|---|
| Bright White | 4.46 |
| Dim Red Light | 1.77 |
211 reviews available for melatonin and Aging
| Article | Year |
|---|---|
Melatonin-related signaling pathways and their regulatory effects in aging organisms.
Topics: Aging; Antioxidants; Free Radicals; Humans; Melatonin; Signal Transduction | 2022 |
Importance of Bmal1 in Alzheimer's disease and associated aging-related diseases: Mechanisms and interventions.
Topics: Adiponectin; Aging; Alzheimer Disease; ARNTL Transcription Factors; Diabetes Mellitus, Type 2; Human | 2022 |
Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases.
Topics: Aging; Animals; Antioxidants; Humans; Mammals; Melatonin; Mitochondria; Neurodegenerative Diseases | 2023 |
Oxidative Stress and Aging as Risk Factors for Alzheimer's Disease and Parkinson's Disease: The Role of the Antioxidant Melatonin.
Topics: Aged; Aging; Alzheimer Disease; Antioxidants; Humans; Melatonin; Neurodegenerative Diseases; Oxidati | 2023 |
Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Glymphatic System; Humans; Melatoni | 2023 |
Review on age-related differences in non-visual effects of light: melatonin suppression, circadian phase shift and pupillary light reflex in children to older adults.
Topics: Adolescent; Aged; Aging; Child; Circadian Rhythm; Humans; Melatonin; Reflex; Reflex, Pupillary; Youn | 2023 |
Melatonin: A review of its potential functions and effects on neurological diseases.
Topics: Aging; Animals; History, 20th Century; History, 21st Century; Humans; Melatonin; Nervous System Dise | 2020 |
Melatonin: Implications for Ocular Disease and Therapeutic Potential.
Topics: Aging; Eye; Free Radicals; Glaucoma; Humans; Melatonin; Uveitis | 2019 |
Impact of Melatonin on Skeletal Muscle and Exercise.
Topics: Aging; Animals; Antioxidants; Exercise; Gastrointestinal Microbiome; Humans; Melatonin; Mitochondria | 2020 |
Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging.
Topics: Aging; Animals; Female; Humans; Melatonin; Ovary; Reproductive Techniques, Assisted | 2020 |
Melatonin: An atypical hormone with major functions in the regulation of angiogenesis.
Topics: Aging; Antioxidants; Apoptosis; Circadian Rhythm; Gene Expression Regulation, Developmental; Humans; | 2020 |
Utilizing Melatonin to Alleviate Side Effects of Chemotherapy: A Potentially Good Partner for Treating Cancer with Ageing.
Topics: Aging; Animals; Antineoplastic Agents; Humans; Melatonin; Mitochondria; Neoplasms; Protective Agents | 2020 |
Single-cell transcriptomics allows novel insights into aging and circadian processes.
Topics: Aging; Circadian Rhythm; Humans; Melatonin; Transcriptome | 2020 |
Melatonin, an ubiquitous metabolic regulator: functions, mechanisms and effects on circadian disruption and degenerative diseases.
Topics: Aging; Animals; Chronobiology Disorders; Humans; Melatonin; Metabolic Networks and Pathways; Metabol | 2020 |
Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly?
Topics: Aged; Aging; Animals; Antioxidants; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug | 2020 |
Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms.
Topics: Aging; Animals; Humans; Melatonin; Nervous System Diseases; Neurogenesis; Oxidative Stress; Protecti | 2020 |
Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Autophagy; Autophagy | 2020 |
Falls Risk, Circadian Rhythms and Melatonin: Current Perspectives.
Topics: Accidental Falls; Aged; Aging; Circadian Rhythm; Humans; Melatonin; Orthostatic Intolerance; Risk As | 2020 |
Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing.
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Peptides; Pineal Gland; Thymus Gland | 2020 |
The role of melatonin in sarcopenia: Advances and application prospects.
Topics: Aged; Aging; Humans; Melatonin; MicroRNAs; Muscle, Skeletal; Quality of Life; Sarcopenia | 2021 |
Melatonin to Rescue the Aged Heart: Antiarrhythmic and Antioxidant Benefits.
Topics: Aging; Animals; Antioxidants; Arrhythmias, Cardiac; Heart; Humans; Melatonin; Oxidative Stress | 2021 |
Biological Rhythm and Chronotype: New Perspectives in Health.
Topics: Aging; Circadian Rhythm; Databases, Factual; Humans; Melatonin; Neoplasms; Sleep | 2021 |
Endocrine and metabolic aspects of COVID-19.
Topics: Aging; Aldosterone; Angiotensin II; Angiotensin-Converting Enzyme 2; COVID-19; Diabetes Mellitus; Hu | 2021 |
Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders.
Topics: Aging; Animals; Antioxidants; Biomarkers; Cognition; Humans; Melatonin; Mental Disorders; Mitochondr | 2021 |
Insomnia: Pharmacologic Treatment.
Topics: Aged; Aging; Antidepressive Agents; Benzodiazepines; Humans; Hypnotics and Sedatives; Melatonin; Ore | 2021 |
Role of Melatonin in Angiotensin and Aging.
Topics: Aging; Angiotensin II; Antioxidants; DNA Damage; Free Radicals; Humans; Melatonin; Mitochondria; Oxi | 2021 |
Melatonin as a promising modulator of aging related neurodegenerative disorders: Role of microRNAs.
Topics: Aging; Animals; Brain; Humans; Melatonin; MicroRNAs; Neurodegenerative Diseases; Neuroprotective Age | 2021 |
[Temporal order deterioration and circadian disruption with age. 2. Systemic mechanisms and correction].
Topics: Age Factors; Aging; Chronobiology Disorders; Circadian Rhythm; Environment; Exercise; Humans; Light; | 2016 |
The role and therapeutic potential of melatonin in age-related ocular diseases.
Topics: Aging; Autophagy; Eye Diseases; Humans; Melatonin; Neovascularization, Physiologic; Nitrosative Stre | 2017 |
Mitochondrial bioenergetics decay in aging: beneficial effect of melatonin.
Topics: Aging; Animals; Antioxidants; Energy Metabolism; Humans; Melatonin; Mitochondria; Mitochondrial Dise | 2017 |
Geroprotectors as a therapeutic strategy for COPD - where are we now?
Topics: Aging; Disease Progression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Me | 2017 |
Aging of lymphoid organs: Can photobiomodulation reverse age-associated thymic involution via stimulation of extrapineal melatonin synthesis and bone marrow stem cells?
Topics: Aging; Animals; Humans; Low-Level Light Therapy; Melatonin; Mesenchymal Stem Cells; T-Lymphocytes; T | 2018 |
Interventions to improve benzodiazepine tapering success in the elderly: a systematic review.
Topics: Aged; Aging; Benzodiazepines; Cognitive Behavioral Therapy; Humans; Melatonin; Progesterone; Randomi | 2019 |
Pineal Calcification, Melatonin Production, Aging, Associated Health Consequences and Rejuvenation of the Pineal Gland.
Topics: Aging; Animals; Calcinosis; Humans; Melatonin; Pineal Gland; Rejuvenation | 2018 |
Mitochondria: Central Organelles for Melatonin's Antioxidant and Anti-Aging Actions.
Topics: Aging; Animals; Antioxidants; Free Radicals; Humans; Melatonin; Mitochondria; Organ Specificity; Oxi | 2018 |
The multiple functions of melatonin in regenerative medicine.
Topics: Aging; Animals; Antioxidants; Circadian Rhythm; Humans; Inflammation; Melatonin; Regeneration; Regen | 2018 |
Mechanisms Underlying Tumor Suppressive Properties of Melatonin.
Topics: Aging; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogenesis; Disease Models, Animal; Disea | 2018 |
The role of melatonin, a multitasking molecule, in retarding the processes of ageing.
Topics: Aging; Animals; Antioxidants; Brain; Circadian Rhythm; Energy Metabolism; Free Radicals; Genomic Ins | 2018 |
Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3.
Topics: Aging; Animals; Humans; Melatonin; Mitochondria; Models, Molecular; Oxidative Phosphorylation; Oxida | 2018 |
Melatonin as Potential Targets for Delaying Ovarian Aging.
Topics: Aging; Autophagy; Endoplasmic Reticulum Stress; Female; Humans; Melatonin; Mitochondria; Ovary; Oxid | 2019 |
Integration of Melatonin Related Redox Homeostasis, Aging, and Circadian Rhythm.
Topics: Aging; Animals; Caloric Restriction; Chronotherapy; Circadian Rhythm; Circadian Rhythm Signaling Pep | 2019 |
Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks.
Topics: Aging; Animals; Biomarkers; Cytokines; Disease Susceptibility; Gene Expression Regulation; Gene Regu | 2019 |
Melatonin: An important anticancer agent in colorectal cancer.
Topics: Aging; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Prolife | 2020 |
Melatonin: buffering the immune system.
Topics: Adjuvants, Immunologic; Aging; Animals; Anti-Inflammatory Agents; Autoimmunity; Humans; Infections; | 2013 |
Sleep and hormonal changes in aging.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Female; Human Growth Hormone; Humans; Hydrocortisone; H | 2013 |
Is there a possible single mediator in modulating neuroendocrine-thymus interaction in ageing?
Topics: Aging; Animals; Arginine; Cytokines; Humans; Hypothalamo-Hypophyseal System; Melatonin; Mice; Neuroi | 2013 |
Cancer and the endogenous "pineal clock": a means of early diagnosis and successful treatment as well as prevention of cancers.
Topics: Aging; Animals; Bone Marrow Transplantation; Circadian Rhythm; Humans; Immunologic Surveillance; Mel | 2013 |
Age-related decline in melatonin and its MT1 receptor are associated with decreased sensitivity to melatonin and enhanced mammary tumor growth.
Topics: Aging; Animals; Breast Neoplasms; Female; Humans; Mammary Neoplasms, Experimental; Melatonin; Mice; | 2013 |
Effects of melatonin on nervous system aging: neurogenesis and neurodegeneration.
Topics: Aged; Aging; Animals; Apoptosis; Cognition Disorders; Humans; Melatonin; Nerve Degeneration; Neural | 2013 |
Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms.
Topics: Aging; Animals; Cellular Senescence; Free Radicals; Humans; Melatonin; Metabolic Syndrome; Models, B | 2013 |
Management of the aging risk factor for Parkinson's disease.
Topics: Acetylcarnitine; Adenosine Triphosphate; Aging; alpha-Synuclein; Antioxidant Response Elements; Carb | 2014 |
Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review.
Topics: Aging; Animals; Antioxidants; Free Radicals; Glutathione Peroxidase; Glutathione Reductase; Humans; | 2014 |
[The effect of melatonin on bone tissue metabolism].
Topics: Aging; Animals; Bone and Bones; Circadian Rhythm; Humans; Melatonin; Mice; Osteoblasts; Osteogenesis | 2014 |
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.
Topics: Aging; Animals; Autophagy; Brain; Caloric Restriction; Circadian Rhythm; Diabetes Mellitus; Energy M | 2014 |
[Age-associated reproductive cycle hypothalamic regulation impairment and its correction].
Topics: Aging; Aging, Premature; Animals; Catecholamines; Circadian Rhythm; Female; Gonadotropin-Releasing H | 2014 |
Melatonin and circadian oscillators in aging--a dynamic approach to the multiply connected players.
Topics: Aging; Antioxidants; Circadian Rhythm; Humans; Melatonin; Oxidative Stress | 2015 |
Protective actions of melatonin and growth hormone on the aged cardiovascular system.
Topics: Aging; Animals; Antioxidants; Apoptosis; Cardiovascular Diseases; Cardiovascular System; Growth Horm | 2014 |
[Sleep problems in dementia].
Topics: Aged; Aged, 80 and over; Aging; Chronobiology Disorders; Circadian Rhythm; Dementia; Humans; Melaton | 2014 |
Melatonin and brain inflammaging.
Topics: Aging; Animals; Brain; Humans; Immunosenescence; Melatonin; Neurodegenerative Diseases; Neuroimmunom | 2015 |
[Melatonin participates in the origin and limitation of bone pathohological processes].
Topics: Aging; Animals; Bone and Bones; Fractures, Bone; Gene Expression Regulation; Humans; Melatonin; Oste | 2015 |
Melatonin in aging women.
Topics: Aging; Animals; Carbohydrate Metabolism; Female; Humans; Lipid Metabolism; Melatonin; Menopause; Neo | 2015 |
Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders.
Topics: Aging; Antioxidants; Humans; Melatonin; Metabolome; Mitochondrial Diseases; Oxidative Stress | 2016 |
The Incremental Induction of Neuroprotective Properties by Multiple Therapeutic Strategies for Primary and Secondary Neural Injury.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antioxidants; Drug Therapy, Combination; Humans; Melatonin | 2015 |
Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies.
Topics: Aging; Animals; Humans; Inflammation Mediators; Melatonin; Metabolic Syndrome; Models, Biological; O | 2017 |
Physiological melatonin levels in healthy older people: A systematic review.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Dementia; Dietary Supplements; Female; Health Stat | 2016 |
[The role of the pineal-thymus system in the regulation of autoimmunity, aging and lifespan].
Topics: Aging; Animals; Autoimmune Diseases; Autoimmunity; Circadian Rhythm; Hormones; Humans; Life Expectan | 2016 |
Circadian rhythm and menopause.
Topics: Aging; Circadian Rhythm; Female; Hot Flashes; Humans; Melatonin; Menopause; Middle Aged; Sex Charact | 2016 |
Melatonin as a Potential Agent in the Treatment of Sarcopenia.
Topics: Aging; Animals; Antioxidants; Humans; Melatonin; Muscle, Skeletal; Osteoporosis; Sarcopenia | 2016 |
Melatonin: Protection against age-related cardiac pathology.
Topics: Aging; Antioxidants; Cardiotonic Agents; Cardiovascular Diseases; Diet, Healthy; Dietary Supplements | 2017 |
Role of neuroendocrine pathways in cognitive decline during aging.
Topics: Aging; Androgens; Animals; Circadian Rhythm; Cognition; Glucocorticoids; Humans; Melatonin; Neurosec | 2008 |
Suprachiasmatic nucleus and melatonin: reciprocal interactions and clinical correlations.
Topics: Aging; Alzheimer Disease; Animals; Circadian Rhythm; Humans; Melatonin; Pineal Gland; Sleep Wake Dis | 2008 |
Melatonin in relation to the "strong" and "weak" versions of the free radical theory of aging.
Topics: Aging; Animals; Free Radicals; Humans; Melatonin; Neurodegenerative Diseases | 2008 |
Melatonin and the immune system in aging.
Topics: Adjuvants, Immunologic; Aged; Aged, 80 and over; Aging; Circadian Rhythm; Cytokines; Granulocyte Pre | 2008 |
Melatonin and melatonergic drugs on sleep: possible mechanisms of action.
Topics: Acetamides; Aging; Animals; Antidepressive Agents; Circadian Rhythm; Depressive Disorder; Humans; Hy | 2009 |
Bioactivity of grape chemicals for human health.
Topics: Aging; Alkaloids; Animals; Antioxidants; Atherosclerosis; Cardiotonic Agents; Chemoprevention; Flavo | 2009 |
[Hormone replacement therapy--growth hormone, melatonin, DHEA and sex hormones].
Topics: Aging; Dehydroepiandrosterone; Female; Gonadal Steroid Hormones; Growth Hormone; Hormone Replacement | 2009 |
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer.
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Models, Biological; Neoplasms; Sirtuins | 2010 |
Melatonin: action as antioxidant and potential applications in human disease and aging.
Topics: Aging; Antioxidants; Clinical Trials as Topic; Free Radical Scavengers; Humans; Melatonin; Oxidation | 2010 |
[Melatonin and oxidative stress in elderly patients with type 2 diabetes].
Topics: Aged; Aging; Antioxidants; Diabetes Mellitus, Type 2; Free Radicals; Humans; Melatonin; Oxidative St | 2010 |
Melatonin, a potential therapeutic agent for smooth muscle-related pathological conditions and aging.
Topics: Aging; Animals; Antioxidants; Colon; Female; Humans; Hypertension; Melatonin; Mice; Muscle Contracti | 2010 |
Melatonin--a pleiotropic, orchestrating regulator molecule.
Topics: Aging; Animals; Binding Sites; Circadian Rhythm; Energy Metabolism; Humans; Immune System; Melatonin | 2011 |
Melatonin--a pleiotropic, orchestrating regulator molecule.
Topics: Aging; Animals; Binding Sites; Circadian Rhythm; Energy Metabolism; Humans; Immune System; Melatonin | 2011 |
Melatonin--a pleiotropic, orchestrating regulator molecule.
Topics: Aging; Animals; Binding Sites; Circadian Rhythm; Energy Metabolism; Humans; Immune System; Melatonin | 2011 |
Melatonin--a pleiotropic, orchestrating regulator molecule.
Topics: Aging; Animals; Binding Sites; Circadian Rhythm; Energy Metabolism; Humans; Immune System; Melatonin | 2011 |
Neuroinflammation and ageing: current theories and an overview of the data.
Topics: Aging; Alzheimer Disease; Apoptosis; Atherosclerosis; Biological Evolution; Brain; Cellular Senescen | 2011 |
Melatonin-mitochondria interplay in health and disease.
Topics: Aging; Animals; Antioxidants; Apoptosis; Biological Evolution; DNA, Mitochondrial; Energy Metabolism | 2011 |
Melatonin and aging: prospects for human treatment.
Topics: Aging; Animals; Circadian Clocks; Energy Intake; Gastrointestinal Tract; Humans; Melatonin | 2011 |
[Effects of melatonin in the brain of the senescence-accelerated mice-prone 8 (SAMP8) model].
Topics: Aging; Animals; Antioxidants; Biomarkers; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycog | 2011 |
[Influence of peptides from pineal gland on thymus function at aging].
Topics: Adjuvants, Immunologic; Aging; Animals; Endocrine Surgical Procedures; Hormone Replacement Therapy; | 2010 |
[Melatonin: its role in the system of neurohumoral regulation in man. Part 2].
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Anticarcinogenic Agents; Blood Pressure; Cardiova | 2011 |
The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Ho | 2012 |
Role of melatonin in the regulation of autophagy and mitophagy: a review.
Topics: Aging; Autophagy; Disease; Humans; Melatonin; Mitophagy | 2012 |
Melatonin, a natural programmed cell death inducer in cancer.
Topics: Aging; Antioxidants; Apoptosis; Circadian Rhythm; Drug Evaluation, Preclinical; Humans; Immune Syste | 2012 |
Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes.
Topics: Aging; Animals; Antioxidants; Apoptosis; Brain Injuries; Circadian Rhythm; Clinical Trials as Topic; | 2013 |
[Physiological and pathophysiological role of the circadian clock system].
Topics: Aging; ARNTL Transcription Factors; Blood Coagulation Disorders; Cardiovascular Diseases; Circadian | 2012 |
Circadian typology: a comprehensive review.
Topics: Aging; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Cognition; Feeding and Eating Di | 2012 |
Psychoneuroendocrine interventions aimed at attenuating immunosenescence: a review.
Topics: Aging; Aging, Premature; Dehydroepiandrosterone; Female; Ghrelin; Human Growth Hormone; Humans; Male | 2013 |
Oxidative stress and immunosenescence: therapeutic effects of melatonin.
Topics: Aged; Aging; Animals; Antioxidants; B-Lymphocytes; Biological Therapy; Cellular Senescence; Humans; | 2012 |
Effect of chronic melatonin administration on several physiological parameters from old Wistar rats and SAMP8 mice.
Topics: Age Factors; Aging; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory | 2012 |
Alterations in the circadian rhythm of salivary melatonin begin during middle-age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Age | 2003 |
Replacement therapy in the aging male.
Topics: Aging; Dehydroepiandrosterone; Growth Hormone; Hormone Replacement Therapy; Humans; Male; Melatonin | 2002 |
Melatonin, longevity and health in the aged: an assessment.
Topics: Age Factors; Aging; Animals; Female; Free Radicals; Melatonin; Mice; Neurodegenerative Diseases; Oxi | 2002 |
Non-vertebrate melatonin.
Topics: Aging; Animals; Antioxidants; Circadian Rhythm; Food; Invertebrates; Melatonin; Photoperiod; Plants, | 2003 |
The relevance of melatonin to sports medicine and science.
Topics: Aging; Body Temperature; Circadian Rhythm; Exercise; Humans; Hypothermia; Jet Lag Syndrome; Melatoni | 2003 |
Light, timing of biological rhythms, and chronodisruption in man.
Topics: Aging; Animals; Biological Clocks; Circadian Rhythm; Environment; Humans; Light; Melatonin; Neoplasm | 2003 |
The therapeutic potential of melatonin: a review of the science.
Topics: Aging; Animals; Antioxidants; Endocrine System Diseases; Humans; Melatonin; Mental Disorders; Neopla | 2004 |
Hormones and immune function: implications of aging.
Topics: Aging; Calcitriol; Dehydroepiandrosterone; Hormones; Human Growth Hormone; Humans; Immunity; Melaton | 2004 |
[Hormone therapy in the aging male. Estrogen, DHEA, melatonin, somatotropin].
Topics: Aged; Aged, 80 and over; Aging; Dehydroepiandrosterone; Estrogens; Growth Hormone; Hormone Replaceme | 2004 |
Retardation of brain aging by chronic treatment with melatonin.
Topics: Aging; Animals; Brain; Cytokines; Gene Expression Regulation; Humans; Inflammation; Melatonin; Neuro | 2004 |
Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders.
Topics: Aging; Animals; Dietary Supplements; Drug Interactions; Gene Expression; Humans; Melatonin; Metals; | 2004 |
The human pineal gland and melatonin in aging and Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Circadian Rhythm; Humans; Melatonin; Phototherapy; Pineal Gland; Sup | 2005 |
[Is there a place for DHEA, GH and melatonin in the management of age-related androgen deficiency?].
Topics: Age Factors; Aged; Aging; Androgens; Clinical Trials as Topic; Dehydroepiandrosterone; Growth Hormon | 2004 |
[Melatonin and its biological significance].
Topics: Affect; Aging; Circadian Rhythm; Humans; Immune System; Melatonin; Sleep Disorders, Circadian Rhythm | 2004 |
[Melatonin].
Topics: Aging; Biomarkers; Breast Neoplasms; Chromatography, High Pressure Liquid; Circadian Rhythm; Depress | 2005 |
Role of melatonin in neurodegenerative diseases.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Brain Chemistry; Brain Injuries; Free Radical Scave | 2005 |
Melatonin and sleep in aging population.
Topics: Aged; Aging; Alzheimer Disease; Body Temperature Regulation; Female; Humans; Indenes; Indoles; Male; | 2005 |
[Sleep and circadian rhythms in ageing].
Topics: Aged, 80 and over; Aging; Circadian Rhythm; Humans; Light; Melatonin; Photic Stimulation; Sleep; Sle | 2005 |
Melatonin, aging, and age-related diseases: perspectives for prevention, intervention, and therapy.
Topics: Aging; Animals; Antioxidants; Geriatrics; Humans; Melatonin; Mitochondria; Oxidative Stress | 2005 |
Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases.
Topics: Aging; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Cell Physiological Phenomena; Cho | 2005 |
[Melatonin: what for?].
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Neoplasms; Sleep Wake Disorders | 2005 |
The trajectory of biomarkers in symptom management for older adults with cancer.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aged; Aging; Anxiety; Biomarkers; Biomarkers, Tumor; Cy | 2006 |
Melatonin and nitric oxide.
Topics: Aging; Animals; Antioxidants; Free Radical Scavengers; Humans; Lipid Peroxidation; Melatonin; Nitric | 2006 |
Age-related changes in the circadian and homeostatic regulation of human sleep.
Topics: Adult; Aged; Aging; Biological Clocks; Circadian Rhythm; Electroencephalography; Homeostasis; Humans | 2006 |
The hormonal fountains of youth: myth or reality?
Topics: Aging; Animals; Dehydroepiandrosterone; Estrogens; Female; Growth Hormone; Hormone Replacement Thera | 2005 |
Sexuality in aging male.
Topics: Aged; Aged, 80 and over; Aging; Dehydroepiandrosterone; Erectile Dysfunction; Fertility; Growth Horm | 2005 |
Controversial endocrine interventions for the aged.
Topics: Aged; Aging; Dehydroepiandrosterone; Endocrine System; Growth Hormone; Growth Hormone-Releasing Horm | 2006 |
Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: role of zinc and arginine.
Topics: Aging; Animals; Arginine; Dietary Supplements; Growth Hormone; Humans; Immune System; Melatonin; Neu | 2006 |
Dietary restriction in aging nonhuman primates.
Topics: Aging; Animals; Basal Metabolism; Caloric Restriction; Dehydroepiandrosterone; Hydrocortisone; Insul | 2007 |
The circadian rhythm of core temperature: effects of physical activity and aging.
Topics: Aging; Body Temperature Regulation; Circadian Rhythm; Exercise; Humans; Melatonin; Motor Activity; S | 2007 |
[Change in rhythms with age].
Topics: Activity Cycles; Aged; Aging; Arousal; Body Temperature Regulation; Circadian Rhythm; Hormones; Huma | 2006 |
Cancer chronomics III. Chronomics for cancer, aging, melatonin and experimental therapeutics researchers.
Topics: Aging; Animals; Antineoplastic Agents; Chronotherapy; Circadian Rhythm; Female; Humans; Lentinan; Ma | 2006 |
Melatonin and the aging brain.
Topics: Aging; Animals; Brain; Brain Chemistry; Encephalitis; Gene Expression Regulation, Enzymologic; Human | 2007 |
Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Biological Clocks; Circadian Rhythm; Disease Progression; Humans; Melatoni | 2007 |
Sleep and aging: 2. Management of sleep disorders in older people.
Topics: Adjuvants, Immunologic; Aged; Aging; Antidepressive Agents; Behavior Therapy; Benzodiazepines; Demen | 2007 |
Live to the rhythm, slave to the rhythm.
Topics: Activity Cycles; Aging; Animals; Biological Clocks; Body Temperature; Circadian Rhythm; Feeding Beha | 2007 |
Neurobiological effects of melatonin as related to cancer.
Topics: Aging; Antineoplastic Agents; Biological Clocks; Clinical Trials as Topic; Drug Evaluation, Preclini | 2007 |
Does melatonin play a role in aging processes?
Topics: Aged; Aging; Antioxidants; Circadian Rhythm; Free Radicals; Humans; Immune System; Melatonin; Pineal | 2007 |
Circadian rhythms of pineal function in rats.
Topics: Acetyltransferases; Aging; Animals; Bucladesine; Circadian Rhythm; Cyclic AMP; Darkness; Female; Lig | 1983 |
[Neuroendocrinology of puberty. Role of melatonin in man].
Topics: Adolescent; Aging; Circadian Rhythm; Female; Humans; Hypothalamo-Hypophyseal System; Luteinizing Hor | 1982 |
Endocrine changes in the newborn period.
Topics: Adrenal Cortex Hormones; Aging; Blood Glucose; Calcitonin; Epinephrine; Ergocalciferols; Female; Gas | 1981 |
Oxidative processes and antioxidative defense mechanisms in the aging brain.
Topics: Aging; Animals; Antioxidants; Brain; Free Radicals; Humans; Melatonin; Oxidation-Reduction; Vitamins | 1995 |
Melatonin comes of age?
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Receptors, Cell Surface; Receptors, Melatonin; | 1995 |
Pineal function during aging: attenuation of the melatonin rhythm and its neurobiological consequences.
Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Circadian Rhythm; Free Radicals; Humans; Hydroxyl Ra | 1994 |
The pineal gland as ontogenetic scanner of reproduction, immunity, and aging. The aging clock.
Topics: Aging; Animals; Energy Metabolism; Humans; Immunity; Melatonin; Pineal Gland; Reproduction; Zinc | 1994 |
Melatonin as a free radical scavenger: implications for aging and age-related diseases.
Topics: Aging; Animals; Antioxidants; Disease; Free Radical Scavengers; Humans; Hydroxyl Radical; In Vitro T | 1994 |
Melatonin synthesis in the gastrointestinal tract and the impact of nutritional factors on circulating melatonin.
Topics: Aging; Animals; Circadian Rhythm; Digestive System; Humans; Melatonin; Nutritional Physiological Phe | 1994 |
The zinc-melatonin interrelationship. A working hypothesis.
Topics: Adrenal Glands; Aging; Animals; Immune System; Melatonin; Mice; Thymus Gland; Zinc | 1994 |
The pineal aging clock. Evidence, models, mechanisms, interventions.
Topics: Aging; Animals; Biological Clocks; Body Temperature Regulation; Child, Preschool; Down Syndrome; Hum | 1994 |
Artificial life extension. The epigenetic approach.
Topics: Aging; Animals; Epistasis, Genetic; Humans; Longevity; Melatonin; Pineal Gland | 1994 |
Diminished pineal function coincides with disturbed circadian endocrine rhythmicity in untreated primary cancer patients. Consequence of premature aging or of tumor growth?
Topics: Aging; Animals; Breast Neoplasms; Circadian Rhythm; Endocrine Glands; Female; Humans; Male; Melatoni | 1994 |
Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis.
Topics: Aging; Animals; Calcium; Free Radical Scavengers; Free Radicals; Glutamates; Glutamic Acid; Humans; | 1993 |
Decreased melatonin biosynthesis, calcium flux, pineal gland calcification and aging: a hypothetical framework.
Topics: Aging; Animals; Calcification, Physiologic; Calcium; Humans; Melatonin; Pineal Gland | 1993 |
The role of melatonin and serotonin in aging: update.
Topics: Aging; Animals; Cell Division; Circadian Rhythm; Humans; Melatonin; Neoplasms; Pineal Gland; Secreto | 1993 |
[Role of melatonin in human physiology and pathology. II. Involvement of melatonin in pathogenesis of affective and chronobiological disorders. Melatonin and the aging process. Melatonin and neoplasms].
Topics: Aging; Chronobiology Phenomena; Humans; Melatonin; Mood Disorders; Neoplasms | 1993 |
Clinical aspects of the melatonin action: impact of development, aging, and puberty, involvement of melatonin in psychiatric disease and importance of neuroimmunoendocrine interactions.
Topics: Aging; Circadian Rhythm; Growth; Humans; Immunity; Melatonin; Mental Disorders; Puberty | 1993 |
Thirty years of human pineal research: do we know its clinical relevance?
Topics: Adult; Aging; Animals; Brain Neoplasms; Child; Circadian Rhythm; Endocrine System Diseases; Humans; | 1996 |
Melatonin in the context of the free radical theory of aging.
Topics: Age Distribution; Aging; Animals; Free Radicals; Glutathione; Melatonin; Sex Factors | 1996 |
[Melatonin: a fashion hormone for not very Cartesian reasons].
Topics: Aged; Aging; Antidepressive Agents; Antineoplastic Agents; Circadian Rhythm; Contraceptive Agents; H | 1996 |
Oxygen radical detoxification processes during aging: the functional importance of melatonin.
Topics: Aging; Animals; Antioxidants; Free Radical Scavengers; Free Radicals; Humans; Melatonin; Pineal Glan | 1995 |
[Pineal functioning (melatonin levels) in healthy children of different ages. An update and the value of pineal gland study in pediatrics].
Topics: Adolescent; Aging; Child; Child, Preschool; Fetal Blood; Humans; Infant; Infant, Newborn; Melatonin; | 1996 |
[Melatonin. Hormone or wonder drug?].
Topics: Adult; Aged; Aging; Alzheimer Disease; Animals; Circadian Rhythm; Depressive Disorder; Humans; Melat | 1996 |
Melatonin, sleep, aging, and the health protection branch.
Topics: Adult; Aged; Aging; Canada; Drug Approval; Female; Humans; Male; Melatonin; Middle Aged; Nonprescrip | 1996 |
[Chronobiological approach of aging].
Topics: Aged; Aging; Chronobiology Phenomena; Circadian Rhythm; Growth Hormone; Humans; Hypothalamo-Hypophys | 1996 |
Melatonin in humans.
Topics: Aging; Animals; Circadian Rhythm; Female; Humans; Male; Melatonin; Neoplasms; Pineal Gland; Puberty; | 1997 |
Melatonin supplements for aging.
Topics: Aged; Aging; Animals; Circadian Rhythm; Depression; Electromagnetic Fields; Feedback; Humans; Melato | 1996 |
[Melatonin and biological rhythms: various aspects in human physiopathology].
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Mental Disorders; Neoplasms; Pineal Gland | 1996 |
Chemotherapy and immunomodulation in the elderly.
Topics: Adjuvants, Immunologic; Aging; Humans; Interferons; Interleukin-2; Melatonin | 1996 |
Melatonin: media hype or therapeutic breakthrough?
Topics: Aging; Circadian Rhythm; Drug Interactions; Humans; Melatonin; Primary Prevention; Sleep Wake Disord | 1997 |
The use of anti-aging hormones. Melatonin, growth hormone, testosterone, and dehydroepiandrosterone: consumer enthusiasm for unproven therapies.
Topics: Aging; Animals; Dehydroepiandrosterone; Female; Human Growth Hormone; Humans; Male; Melatonin; Nonpr | 1997 |
Melatonin as an antiaging drug: between facts and fantasy.
Topics: Aging; Animals; Brain; Circadian Rhythm; Humans; Immune System; Melatonin; Safety; Signal Transducti | 1996 |
Insulin exposure and aging theory.
Topics: Aging; Animals; Basal Metabolism; Dogs; Energy Intake; Growth Hormone; Haplorhini; Horses; Humans; I | 1997 |
Plasticity of neuro-endocrine-thymus interactions during aging--a minireview.
Topics: Age Factors; Aging; Animals; Humans; Melatonin; Neurosecretory Systems; Rejuvenation; Thymic Factor, | 1997 |
Sleep disorders and aging: understanding the causes.
Topics: Aging; Circadian Rhythm; Health Status; Humans; Hypnotics and Sedatives; Melatonin; Mental Health; S | 1997 |
Melatonin as a hormone and an antioxidant: implications for organisms at high latitudes.
Topics: Aging; Animals; Antioxidants; Circadian Rhythm; Free Radical Scavengers; Geography; Humans; Light; M | 1997 |
The accelerated aging hypothesis of Parkinson's disease is not supported by the pattern of circadian melatonin secretion.
Topics: Aging; Alzheimer Disease; Circadian Rhythm; Dopamine; Humans; Melatonin; Middle Aged; Parkinson Dise | 1997 |
Melatonin and aging: facts and artifacts.
Topics: Aging; Artifacts; Humans; Melatonin | 1997 |
Melatonin in aged women. Possible modulation by estrogens.
Topics: Aged; Aging; Estrogens; Female; Humans; Melatonin | 1997 |
Prophylactic actions of melatonin in oxidative neurotoxicity.
Topics: Aging; Animals; Brain; Free Radicals; Humans; Melatonin; Neuroprotective Agents; Oxidative Stress | 1997 |
Neurobiology of retinal dopamine in relation to degenerative states of the tissue.
Topics: Aging; Animals; Dopamine; Humans; Mammals; Melatonin; Parkinson Disease; Retina; Retinal Degeneratio | 1997 |
[Melatonin in the human--an overview].
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Infant; M | 1997 |
[Is melatonin an antioxidant?].
Topics: Aging; Animals; Antioxidants; Humans; Hydroxyl Radical; Melatonin; Peroxides; Reactive Oxygen Specie | 1997 |
[The physiological functions of the epiphysis (the gerontological aspect)].
Topics: Aging; Animals; Female; Humans; Light; Longevity; Male; Melatonin; Pineal Gland | 1997 |
Melatonin, immune modulation and aging.
Topics: Aging; Animals; Antibody Formation; Communicable Diseases; Hormones; Humans; Immunity, Innate; Lymph | 1997 |
[Melatonin. Physiology, pathophysiology and possible therapeutic approaches].
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Sexual Maturation; Sleep Stages | 1998 |
[The antioxidant capacity of melatonin: its defensive role against age-related diseases].
Topics: Age Factors; Aged; Aging; Animals; Antioxidants; Female; Free Radicals; Humans; Life Expectancy; Mal | 1998 |
[Melatonin: a popular hormone].
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Animals; Child; Child, Preschool; Circadian Rhythm; Con | 1998 |
"Melatonin replacement therapy" for postmenopausal women: is it justified?
Topics: Aging; Animals; Breast Neoplasms; Circadian Rhythm; Female; Humans; Melatonin; Postmenopause; Sleep | 1998 |
Cytoprotective properties of melatonin: presumed association with oxidative damage and aging.
Topics: Aging; Animals; Antioxidants; Cytoprotection; Free Radical Scavengers; Humans; Melatonin; Nutritiona | 1998 |
Reactive oxygen intermediates, molecular damage, and aging. Relation to melatonin.
Topics: Aging; Animals; Circadian Rhythm; Free Radical Scavengers; Humans; Melatonin; Pineal Gland; Reactive | 1998 |
Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristics.
Topics: Adult; Aged; Aging; Circadian Rhythm; Electroencephalography; Humans; Male; Melatonin; Sleep; Sleep | 1999 |
Urinary 6-sulfatoxymelatonin excretion and aging: new results and a critical review of the literature.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Circadian Rhythm; Female; Humans; Male; Me | 1999 |
Approaches to anti-aging intervention: the promises and the uncertainties.
Topics: Aging; Antioxidants; Dehydroepiandrosterone; Diet; Estrogens; Geriatrics; Growth Hormone; Humans; Li | 1999 |
Hormone replacement in the aging male?.
Topics: Aging; Androgens; Dehydroepiandrosterone; Hormone Replacement Therapy; Human Growth Hormone; Humans; | 1999 |
Comparison of the pineal and SCN rhythmicity. Effect of photic and non-photic stimuli, photoperiod, and age.
Topics: Aging; Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Mammals; Melatonin; Photoperiod; Pi | 1999 |
Melatonin and aging.
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin | 1999 |
Alterations with aging of the endocrine and neuroendocrine circadian system in humans.
Topics: Aged; Aging; Body Temperature; Calcitonin; Catecholamines; Circadian Rhythm; Electrolytes; Female; G | 2000 |
[Melatonin and aging].
Topics: Aging; Animals; Antioxidants; Biological Clocks; Free Radical Scavengers; Humans; Melatonin; Pineal | 1997 |
Melatonin and development: physiology and pharmacology.
Topics: Adolescent; Adult; Aging; Child; Circadian Rhythm; Female; Fetus; Humans; Infant; Melatonin; Pregnan | 2000 |
Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals.
Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Antioxidants; Catalase; Drosophila melanogaster; Fre | 2001 |
Human aging and melatonin. Clinical relevance.
Topics: Aging; Animals; Antioxidants; Free Radical Scavengers; Humans; Melatonin; Sleep | 2001 |
Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging.
Topics: Aging; Animals; Antioxidants; Cell Respiration; Humans; Melatonin; Mitochondria; Oxidants; Reactive | 2002 |
Melatonin and aging.
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Pineal Gland | 2002 |
Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin.
Topics: Aging; Animals; Humans; Melatonin; Mitochondria; Oxidation-Reduction; Oxygen; Reactive Nitrogen Spec | 2002 |
Senescence, sleep, and circadian rhythms.
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders | 2002 |
Some perturbations that disturb the circadian melatonin rhythm.
Topics: Aging; Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Darkness; Humans; Hypophysectomy; L | 1992 |
The ageing pineal gland and its physiological consequences.
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Pineal Gland | 1992 |
Rhythmic release pattern of pineal melatonin in rodents.
Topics: Aging; Animals; Circadian Rhythm; Melatonin; Periodicity; Pineal Gland; Rabbits; Rats; Sympathetic N | 1991 |
Pineal gland and aging.
Topics: Aging; Animals; beta-Endorphin; Female; Gonadotropins, Pituitary; Humans; Male; Melatonin; Pineal Gl | 1991 |
Age-related disruption of circadian rhythms: possible relationship to memory impairment and implications for therapy with magnetic fields.
Topics: Adult; Aged; Aging; Animals; Circadian Rhythm; Humans; Magnetics; Melatonin; Memory Disorders; Middl | 1991 |
[Function of the pineal body in cancer and aging].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Child; Child, Preschool; Female; Humans; | 1990 |
Possible role of pineal melatonin in the mechanisms of aging.
Topics: Aging; Free Radicals; Humans; Melatonin; Oxygen; Pineal Gland | 1990 |
Light effects on human circadian rhythms: a review of recent Andechs experiments.
Topics: Acoustic Stimulation; Aging; Biomarkers; Circadian Rhythm; Humans; Light; Lighting; Melatonin; Socia | 1989 |
Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its anti-aging effects.
Topics: Aging; Animals; Circadian Rhythm; Endorphins; Hematopoiesis; Immunity; Melatonin; Mice; Neoplasms, E | 1987 |
Determinants of puberty in a seasonal breeder.
Topics: Aging; Animals; Estradiol; Estrus; Female; Fertility; Follicular Phase; Gonadotropins; Humans; Hypot | 1986 |
25 trials available for melatonin and Aging
| Article | Year |
|---|---|
Sexual behaviour, semen quality and fertility of young Border Leicester rams administered melatonin during spring.
Topics: Aging; Animals; Fertility; Male; Melatonin; Seasons; Semen Analysis; Sexual Behavior, Animal; Sexual | 2021 |
Cancer as the main aging factor for humans: the fundamental role of 5-methoxy-tryptamine in reversal of cancer-induced aging processes in metabolic and immune reactions by non-melatonin pineal hormones.
Topics: 5-Methoxytryptamine; Administration, Oral; Age Factors; Aging; Antineoplastic Combined Chemotherapy | 2012 |
A Jerte valley cherry product provides beneficial effects on sleep quality. Influence on aging.
Topics: Actigraphy; Adult; Aged; Aged, 80 and over; Aging; Body Mass Index; Cross-Over Studies; Dietary Supp | 2013 |
Melatonin implants do not alter estrogen feedback or advance puberty in gilts.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Estradiol; Estrogens; Female; Luteinizing Hormone; | 2015 |
Can sleep quality and wellbeing be improved by changing the indoor lighting in the homes of healthy, elderly citizens?
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Cross-Over Studies; Female; Humans; Light; Male; M | 2015 |
[Effect of the pineal gland peptide preparation on the diurnal profile of arterial pressure in middle-aged and elderly women with ischemic heart disease and arterial hypertension].
Topics: Aged; Aging; Angina Pectoris; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Am | 2008 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Depressive Disorder, Major; Double-Blind Method; F | 2011 |
Peptide geroprotector from the pituitary gland inhibits rapid aging of elderly people: results of 15-year follow-up.
Topics: Aged; Aging; Blood Glucose; Carbohydrate Metabolism; Cardiovascular Diseases; Cardiovascular System; | 2011 |
Effect of melatonin supplementation on the ontogeny of immunity in the Large White turkey poult.
Topics: Aging; Animals; Antibody Formation; Basophils; Dietary Supplements; Erythrocytes; Hypersensitivity; | 2002 |
Emergence and evolution of the circadian rhythm of melatonin in children.
Topics: Aging; Biological Evolution; Circadian Rhythm; Enzyme-Linked Immunosorbent Assay; Female; Humans; In | 2003 |
Effect of melatonin-rich night-time milk on sleep and activity in elderly institutionalized subjects.
Topics: Aged; Aging; Animals; Circadian Rhythm; Cross-Over Studies; Delayed-Action Preparations; Dose-Respon | 2005 |
Effects of melatonin in age-related macular degeneration.
Topics: Aged; Aged, 80 and over; Aging; Case-Control Studies; Female; Humans; Macular Degeneration; Male; Me | 2005 |
The circadian body temperature rhythm in the elderly: effect of single daily melatonin dosing.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Body Temperature; Body Temperature Regulation; Ci | 2006 |
Investigation of biochemical factors related to non-bothersome nocturnal urination.
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Male; Melatonin; Middle Aged; Prostatitis; Qu | 2007 |
Hypothermic effect of melatonin and nocturnal core body temperature decline are reduced in aged women.
Topics: Adult; Aging; Body Temperature; Circadian Rhythm; Female; Humans; Melatonin; Middle Aged | 1995 |
Melatonin enhances cortisol levels in aged but not young women.
Topics: Administration, Oral; Adult; Aging; Androstenedione; Circadian Rhythm; Double-Blind Method; Estradio | 1995 |
[Melatonin. Hormone or wonder drug?].
Topics: Adult; Aged; Aging; Alzheimer Disease; Animals; Circadian Rhythm; Depressive Disorder; Humans; Melat | 1996 |
Relationship between napping and melatonin in the blind.
Topics: Adult; Aged; Aging; Blindness; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Sleep | 1997 |
Melatonin enhances cortisol levels in aged women: reversible by estrogens.
Topics: Aging; Double-Blind Method; Estrogens; Female; Humans; Hydrocortisone; Melatonin; Middle Aged; Postm | 1997 |
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms.
Topics: Adult; Aged; Aging; Body Temperature; Circadian Rhythm; Electrocardiography; Female; Homeostasis; Hu | 1999 |
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms.
Topics: Adult; Aged; Aging; Body Temperature; Circadian Rhythm; Electrocardiography; Female; Homeostasis; Hu | 1999 |
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms.
Topics: Adult; Aged; Aging; Body Temperature; Circadian Rhythm; Electrocardiography; Female; Homeostasis; Hu | 1999 |
Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms.
Topics: Adult; Aged; Aging; Body Temperature; Circadian Rhythm; Electrocardiography; Female; Homeostasis; Hu | 1999 |
Peripheral heat loss: a predictor of the hypothermic response to melatonin administration in young and older women.
Topics: Adult; Aged; Aging; Antioxidants; Body Temperature; Body Temperature Regulation; Female; Hot Tempera | 1999 |
The effect of age and pre-light melatonin concentration on the melatonin sensitivity to dim light.
Topics: Adolescent; Adult; Aging; Area Under Curve; Female; Humans; Male; Melatonin; Photic Stimulation; Rad | 1999 |
The relationship between 6-sulphatoxymelatonin rhythm phase and age in self-reported good sleeping controls and sleep maintenance insomniacs aged 55-80 years.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Slee | 1999 |
Melatonin secretion occurs at a constant rate in both young and older men and women.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aging; Antioxidants; Circadian Rhythm; Female; Human | 2001 |
Do plasma melatonin concentrations decline with age?
Topics: Adult; Aged; Aging; Circadian Rhythm; Confidence Intervals; Female; Humans; Male; Melatonin; Middle | 2000 |
587 other studies available for melatonin and Aging
| Article | Year |
|---|---|
Molecular Evidence of the Inhibitory Potential of Melatonin against NaAsO
Topics: Aging; Animals; Arsenites; Male; Melatonin; Mice; Sodium Compounds | 2021 |
Metabolic footprint in young, middle-aged and elderly rats with melatonin deficit.
Topics: Aging; Animals; Mammals; Melatonin; Oxidative Stress; Physical Conditioning, Animal; Pineal Gland; R | 2022 |
The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1.
Topics: Aging; Aminobutyrates; Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; gamma-Ami | 2022 |
Chronic Treatment with Melatonin Improves Hippocampal Neurogenesis in the Aged Brain and Under Neurodegeneration.
Topics: Aging; Animals; Hippocampus; Melatonin; Mice; Neural Stem Cells; Neurogenesis; Neurons | 2022 |
Melatonin activates mitochondrial unfolded protein response to preserve osteogenic potential of senescent BMSCs via upregulating PDI-6.
Topics: Aging; Animals; beta Catenin; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Melatonin; M | 2023 |
[Effect of pharmacological stimulation of melatonin receptors on renal function in aging.]
Topics: Aging; Animals; Kidney; Male; Melatonin; Rats; Receptors, Melatonin; Water | 2023 |
Effects of melatonin on a d-galactose-induced male reproductive aging mouse model.
Topics: Aging; Animals; Disease Models, Animal; Galactose; Male; Melatonin; Mice; Rodent Diseases; Semen; Te | 2023 |
Melatonin as mitochondria-targeted drug.
Topics: Aging; Antioxidants; Humans; Melatonin; Mitochondria; Oxidative Stress | 2023 |
Effects of High-Intensity Interval Training on Melatonin Function and Cellular Lymphocyte Apoptosis in Sedentary Middle-Aged Men.
Topics: Aged; Aging; Antioxidants; Apoptosis; Exercise; High-Intensity Interval Training; Humans; Male; Mela | 2023 |
Hormone Therapy: Aging-Related Hormone Replacement Therapy and Supplementation.
Topics: Aging; Dehydroepiandrosterone; Dietary Supplements; Hormone Replacement Therapy; Humans; Melatonin | 2023 |
Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus).
Topics: Aging; Animals; Coleoptera; Colon; Energy Metabolism; Gerbillinae; Inflammation; Melatonin; Mice; Ra | 2023 |
Melatonin ameliorates histone modification disorders in mammalian aged oocytes by neutralizing the alkylation of HDAC1.
Topics: Aging; Alkylation; Animals; Histone Code; Histone Deacetylase 1; Histones; Mammals; Melatonin; Mice; | 2023 |
Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo.
Topics: Aged; Aging; Biomarkers; Collagen; Epidermis; Eyelids; Humans; Melatonin; Skin; Skin Aging | 2023 |
Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus.
Topics: Adenosine Triphosphate; Aging; Animals; Apoptosis; Cognitive Dysfunction; Drug Synergism; Hippocampu | 2019 |
Aging Successfully: The Role of Genetics and Environment in the Era of the Aging-Boom. Potential Therapeutic Implications.
Topics: Aging; Epigenesis, Genetic; Eye Diseases; Humans; Immune System; Longevity; Melatonin; Methotrexate; | 2019 |
Melatonin alleviates vascular calcification and ageing through exosomal miR-204/miR-211 cluster in a paracrine manner.
Topics: Aging; Animals; Cell Differentiation; Exosomes; Humans; Melatonin; Mice; Mice, Inbred C57BL; MicroRN | 2020 |
Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the SIRT2-dependent H4K16 deacetylation pathway.
Topics: Acetylation; Age Factors; Aging; Animals; Dietary Supplements; Gene Expression; Histones; Maternal A | 2020 |
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration.
Topics: Aging; Animals; Cytosol; DNA, Mitochondrial; Female; Humans; Huntington Disease; Male; Melatonin; Mi | 2020 |
Can melatonin reduce the severity of COVID-19 pandemic?
Topics: Age Factors; Aged; Aging; Animals; Antioxidants; Betacoronavirus; Chiroptera; Circadian Rhythm; Coro | 2020 |
Interleukin-6 and Melatonin as Predictors of Cognitive, Emotional and Functional Ageing of Older People.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Aging; Biomarkers; Cognition; Cross-Sectional S | 2020 |
Lack of retinoid acid receptor-related orphan receptor alpha accelerates and melatonin supplementation prevents testicular aging.
Topics: Aging; Animals; Apoptosis; Dietary Supplements; Male; Melatonin; Mice; Nuclear Receptor Subfamily 1, | 2020 |
Melatonin supplementation over different time periods until ageing modulates genotoxic parameters in mice.
Topics: Aging; Animals; Biomarkers; Comet Assay; Dietary Supplements; DNA Damage; Duration of Therapy; Genom | 2020 |
Age-dependent altered redox homeostasis in the chronodisrupted rat model and moderation by melatonin administration.
Topics: Aging; Animals; Circadian Rhythm; Homeostasis; Light; Male; Melatonin; Oxidation-Reduction; Rats; Ra | 2020 |
Melatonin down-regulates steroidal hormones, thymocyte apoptosis and inflammatory cytokines in middle-aged T. cruzi infected rats.
Topics: Aging; Aldosterone; Animals; Apoptosis; Corticosterone; Cortisone; Cytokines; Interleukin-1alpha; In | 2020 |
Oral administration of melatonin contained in drinking water increased bone strength in naturally aged mice.
Topics: Administration, Oral; Aging; Animals; Bone Density; Drinking Water; Male; Melatonin; Mice; Receptors | 2020 |
Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies.
Topics: Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Case-Control Studies; Epithelium; Female; Follow- | 2020 |
[AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.]
Topics: Aged; Aging; Circadian Rhythm; Genes; Humans; Melatonin; Middle Aged; Peptides; Pineal Gland | 2020 |
Nicotinamide mononucleotide and melatonin counteract myocardial ischemia-reperfusion injury by activating SIRT3/FOXO1 and reducing apoptosis in aged male rats.
Topics: Aging; Animals; Apoptosis; Drug Combinations; Forkhead Box Protein O1; Heart; Male; Melatonin; Myoca | 2021 |
Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve.
Topics: Aging; Amino Acid Transport System A; Animals; Female; Fertility; Melatonin; Mice; Mice, Inbred C57B | 2021 |
Long-term melatonin treatment attenuates body weight gain with aging in female mice.
Topics: Adiposity; Aging; Animals; Antioxidants; Female; Melatonin; Mice; Mice, Inbred ICR; Weight Gain | 2021 |
Research progress of melatonin (MT) in improving ovarian function: a review of the current status.
Topics: Aging; Animals; Antioxidants; Female; Humans; Melatonin; Ovarian Diseases; Ovary; Stimulation, Chemi | 2021 |
Daily Socs1 rhythms alter with aging differentially in peripheral clocks in male Wistar rats: therapeutic effects of melatonin.
Topics: Aging; Animals; Biological Clocks; Kidney; Liver; Male; Melatonin; Myocardium; Rats; Rats, Wistar; R | 2017 |
Melatonin: Antioxidant and modulatory properties in age-related changes during Trypanosoma cruzi infection.
Topics: Aging; Animals; Antioxidants; CD28 Antigens; Chagas Disease; Macrophages, Peritoneal; Male; Melatoni | 2017 |
Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques.
Topics: Aging; Animals; Caloric Restriction; Energy Intake; Female; Humans; Macaca mulatta; Male; Melatonin | 2017 |
Daily chronomics of proteomic profile in aging and rotenone-induced Parkinson's disease model in male Wistar rat and its modulation by melatonin.
Topics: Age Factors; Aging; Animals; Biomarkers; Brain; Circadian Rhythm; Disease Models, Animal; Electropho | 2017 |
Comparing the Effects of Melatonin with Caloric Restriction in the Hippocampus of Aging Mice: Involvement of Sirtuin1 and the FOXOs Pathway.
Topics: Aging; Animals; Caloric Restriction; Forkhead Transcription Factors; Gene Expression; Hippocampus; H | 2018 |
Effects of differences in the availability of light upon the circadian rhythms of institutionalized elderly.
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Quality of | 2017 |
Melatonin promotes osteoblast differentiation of bone marrow mesenchymal stem cells in aged rats.
Topics: Adipocytes; Aging; Alkaline Phosphatase; Animals; Bone and Bones; Bone Marrow Cells; Cell Differenti | 2017 |
Melatonin modulates neuronal mitochondria function during normal ageing in mice.
Topics: Aging; Animals; Calcium; DNA, Mitochondrial; Melatonin; Mice; Mitochondria; Neurons; Oxidative Stres | 2017 |
The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes.
Topics: Aging; Animals; Female; Lactic Acid; Magnetic Resonance Imaging; Melatonin; Mice; Mice, Inbred C57BL | 2018 |
Human colostrum action against Giardia lamblia infection influenced by hormones and advanced maternal age.
Topics: Adolescent; Adult; Aging; Animals; Child; Colostrum; Cross-Sectional Studies; Female; Giardia lambli | 2018 |
Circadian rhythm resynchronization improved isoflurane-induced cognitive dysfunction in aged mice.
Topics: Aging; Anesthetics, Inhalation; Animals; Body Temperature; Circadian Rhythm; CLOCK Proteins; Cogniti | 2018 |
Effect of Melatonin on Rat Heart Mitochondria in Acute Heart Failure in Aged Rats.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Aging; Animals; Calcium; Cell Respiration; Cryoultrami | 2018 |
The influence of ageing on the extrapineal melatonin synthetic pathway.
Topics: Aging; Animals; Antioxidants; Catalase; Copper; Liver; Melatonin; Rats; Rats, Wistar; Reactive Oxyge | 2018 |
Comparison of the Effect of Melatonin Treatment before and after Brain Ischemic Injury in the Inflammatory and Apoptotic Response in Aged Rats.
Topics: Aging; Animals; Apoptosis; bcl-2-Associated X Protein; Brain Ischemia; Gene Expression Regulation; G | 2018 |
Aging, melatonin biosynthesis, and circadian clockworks in the gastrointestinal system of the laboratory mouse.
Topics: Aging; Animals; Arylalkylamine N-Acetyltransferase; Autophagy-Related Proteins; Circadian Clocks; Ci | 2019 |
Lack of NLRP3 Inflammasome Activation Reduces Age-Dependent Sarcopenia and Mitochondrial Dysfunction, Favoring the Prophylactic Effect of Melatonin.
Topics: Aging; Animals; Biopsy, Needle; Female; Gene Expression Regulation; Immunohistochemistry; Inflammaso | 2019 |
Exogenous Melatonin Up-Regulates Expression of CD62L by Lymphocytes in Aged Mice under Inflammatory and Non-Inflammatory Conditions.
Topics: Aging; Animals; CD8-Positive T-Lymphocytes; Humans; Inflammation; Killer Cells, Natural; L-Selectin; | 2019 |
Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high-fat diet.
Topics: Aging; Animals; Cholinergic Neurons; Cognitive Dysfunction; Dietary Fats; Female; Hippocampus; Insul | 2019 |
The physiological and lifespan alterations in Caenorhabditis elegans exposed to different dosages of melatonin.
Topics: Aging; Animals; Caenorhabditis elegans; Dose-Response Relationship, Drug; Longevity; Melatonin | 2019 |
Aging in the Syrian hamster testis: Inflammatory-oxidative status and the impact of photoperiod.
Topics: Aging; Animals; Cricetinae; Male; Melatonin; Mesocricetus; Oxidative Stress; Photoperiod; Testis | 2019 |
Physiological, behavioral and environmental factors influence bifurcated circadian entrainment in mice.
Topics: Aging; Animals; Behavior, Animal; Circadian Rhythm; Diet; Diet, High-Fat; Environment; Female; Light | 2019 |
Rest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonin.
Topics: Aging; Animals; Chronobiology Disorders; Circadian Rhythm; Cyprinodontiformes; Disease Progression; | 2013 |
Decline in cytochrome c oxidase activity in rat-brain mitochondria with aging. Role of peroxidized cardiolipin and beneficial effect of melatonin.
Topics: Aging; Animals; Brain; Cardiolipins; Electron Transport Complex IV; Hydrogen-Ion Concentration; Male | 2013 |
Melatonin improves insulin sensitivity independently of weight loss in old obese rats.
Topics: Aging; Animals; Antioxidants; Dietary Supplements; Drug Evaluation, Preclinical; Glucose Metabolism | 2013 |
Attenuation of age-related increase of protein carbonylation in the liver of mice by melatonin and curcumin.
Topics: Aging; Animals; Blotting, Western; Curcumin; Female; Liver; Melatonin; Mice; Mice, Inbred BALB C; Pr | 2013 |
Age-related changes in melatonin release in the murine distal colon.
Topics: Aging; Animals; Central Nervous System Depressants; Colon; Electrochemical Techniques; Enterochromaf | 2013 |
Adaptations of the aging animal to exercise: role of daily supplementation with melatonin.
Topics: Adaptation, Physiological; Adipose Tissue; Aging; Animals; Antioxidants; Dietary Supplements; Liver; | 2013 |
Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male rats.
Topics: Aging; Animals; Apoptosis; Base Sequence; Dentate Gyrus; DNA Primers; Growth Hormone; Male; Melatoni | 2013 |
[The sexual peculiarities of aging changes in circannual rhythms of pineal gland, hypophysis, adrenal cortex and thymus functions in healthy subjects].
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Aged; Aging; Biomarkers; Circadian Rhythm; Femal | 2013 |
[Potential of melatonin for prevention of age-related macular degeneration: experimental study].
Topics: Aging; Animals; Antioxidants; Disease Models, Animal; Follow-Up Studies; Macular Degeneration; Male; | 2013 |
Urinary 6-sulphatoxymelatonin levels in patients with senile cataracts.
Topics: Aged; Aging; Antioxidants; Case-Control Studies; Cataract; Enzyme-Linked Immunosorbent Assay; Female | 2013 |
Intake of melatonin increases tryptophan hydroxylase type 1 activity in aged rats: Preliminary study.
Topics: Aging; Animals; Antioxidants; Circadian Rhythm; Drug Administration Schedule; Drug Evaluation, Precl | 2014 |
Dietary melatonin attenuates age-related changes in morphology and in levels of key proteins in globus pallidus of mouse brain.
Topics: Aging; Animals; Dietary Supplements; Glial Fibrillary Acidic Protein; Globus Pallidus; Male; Melaton | 2014 |
Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?
Topics: Adult; Aging; Circadian Clocks; Circadian Rhythm; Female; Humans; Lens, Crystalline; Light; Male; Me | 2014 |
Melatonin and the Charlson Comorbidity Index (CCI): the Treviso Longeva (Trelong) study.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Cardiovascular Diseases; Cohort Studies; Comorbidity; E | 2014 |
Melatonin dietary supplement as an anti-aging therapy for age-related bone loss.
Topics: Aging; Animals; Antioxidants; Bone and Bones; Bone Density; Dietary Supplements; Disease Models, Ani | 2014 |
Differential role of melatonin in restoration of age-induced alterations in daily rhythms of expression of various clock genes in suprachiasmatic nucleus of male Wistar rats.
Topics: Aging; Animals; Antioxidants; ARNTL Transcription Factors; Circadian Rhythm; Circadian Rhythm Signal | 2014 |
[The aging particularities of bone marrow composition, pineal gland and thymus functions in mice of different lines].
Topics: Aging; Animals; Bone Marrow Cells; Disease Models, Animal; Fibroblasts; Macrophages; Male; Melatonin | 2013 |
[Morpho-functional characteristics of intestine epitheliocytes at health and diseases in humans of various ages].
Topics: Adult; Aged; Aging; Humans; Intestinal Diseases; Intestinal Mucosa; Intestines; Melatonin; Middle Ag | 2013 |
Effects of melatonin on aluminium-induced neurobehavioral and neurochemical changes in aging rats.
Topics: Acetylcholinesterase; Aging; Aluminum; Animals; Behavior, Animal; Body Weight; Brain; Catalase; Glut | 2014 |
Urine 6-sulfatoxymelatonin levels are inversely associated with arterial stiffness in post-menopausal women.
Topics: Aging; Atherosclerosis; Female; Humans; Logistic Models; Melatonin; Middle Aged; Odds Ratio; Postmen | 2014 |
Association between urinary 6-sulfatoxymelatonin excretion and arterial stiffness in the general elderly population: the HEIJO-KYO cohort.
Topics: Aged; Aged, 80 and over; Aging; Ankle Brachial Index; Atherosclerosis; Biomarkers; Body Mass Index; | 2014 |
Melatonin enhances adult rat hippocampal progenitor cell proliferation via ERK signaling pathway through melatonin receptor.
Topics: Adult Stem Cells; Aging; Animals; Blotting, Western; Cell Proliferation; Hippocampus; MAP Kinase Sig | 2014 |
Expression of genes for AhR and Nrf2 signal pathways in the retina of OXYS rats during the development of retinopathy and melatonin-induced changes in this process.
Topics: Aging; Animals; Antioxidants; Basic Helix-Loop-Helix Transcription Factors; Cytochrome P-450 CYP1A2; | 2014 |
[Light pollution, desynchronosis and aging: the state of problem and solutions].
Topics: Aging; Aging, Premature; Animals; Antioxidants; Humans; Light; Lighting; Longevity; Melatonin; Model | 2014 |
Asymmetric dimethylarginine attenuates the association of melatonin secretion with night-time blood pressure and dipping in elderly individuals.
Topics: Aged; Aged, 80 and over; Aging; Arginine; Blood Pressure; Body Mass Index; Circadian Rhythm; Cross-S | 2014 |
A longitudinal assessment of sleep timing, circadian phase, and phase angle of entrainment across human adolescence.
Topics: Actigraphy; Adolescent; Aging; Child; Circadian Rhythm; Female; Humans; Longitudinal Studies; Male; | 2014 |
Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Brain; Disease Models, Animal; Galactose; Inflammat | 2015 |
The role of melatonin, sirtuin2 and FoXO1 transcription factor in the aging process of colon in male rats.
Topics: Aging; Animals; Colon; Forkhead Transcription Factors; Intestinal Mucosa; Lipid Peroxidation; Male; | 2015 |
Melatonin maintains calcium-binding calretinin-positive neurons in the dentate gyrus during aging of Balb/C mice.
Topics: Aging; Animals; Calbindin 2; Calcium; Dentate Gyrus; Immunohistochemistry; Male; Melatonin; Mice; Mi | 2014 |
Melatonin has differential effects on age-induced stoichiometric changes in daily chronomics of serotonin metabolism in SCN of male Wistar rats.
Topics: 5-Hydroxytryptophan; Aging; Animals; Chronobiology Phenomena; Circadian Rhythm; Hydroxyindoleacetic | 2015 |
Circadian clocks in rat skin and dermal fibroblasts: differential effects of aging, temperature and melatonin.
Topics: Aging; Animals; Cells, Cultured; Circadian Clocks; Circadian Rhythm; Fibroblasts; Gene Expression Re | 2015 |
Melatonin administration enhances the reproductive capacity of young rams under a southern Mediterranean environment.
Topics: Aging; Animals; Body Weight; Fertility; Libido; Male; Melatonin; Reproduction; Scrotum; Seasons; Sem | 2015 |
Melatonin delays leaf senescence and enhances salt stress tolerance in rice.
Topics: Aging; Gene Expression Regulation, Plant; Hydrogen Peroxide; Melatonin; Molecular Sequence Data; Ory | 2015 |
Some hormone, cytokine and chemokine levels that change across lifespan vary by cognitive status in male Fischer 344 rats.
Topics: Adrenocorticotropic Hormone; Age Factors; Aging; Animals; Cerebral Cortex; Chemokines; Cognition; Co | 2015 |
Melatonin membrane receptor (MT1R) expression and nitro-oxidative stress in testis of golden hamster, Mesocricetus auratus: An age-dependent study.
Topics: Aging; Animals; Antioxidants; Male; Melatonin; Mesocricetus; Nitric Oxide; Oxidative Stress; Recepto | 2015 |
Melatonin treatment in spring and reproductive recovery in sheep with different body condition score and age.
Topics: Aging; Animals; Body Composition; Female; Melatonin; Pregnancy; Reproduction; Seasons; Sheep | 2015 |
Effects of Geroprotectors on Age-Related Changes in Proteolytic Digestive Enzyme Activities at Different Lighting Conditions.
Topics: Age Factors; Aging; Animals; Animals, Outbred Strains; Circadian Rhythm; Digestion; Enzyme Activatio | 2015 |
Short photoperiod condition increases susceptibility to stress in adolescent male rats.
Topics: Aging; Anhedonia; Animals; Circadian Rhythm; Corticosterone; Disease Models, Animal; Disease Suscept | 2016 |
Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence-accelerated mice model.
Topics: Aging; Aging, Premature; Animals; Apoptosis; Biomarkers; Disease Models, Animal; Dose-Response Relat | 2016 |
Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.
Topics: Aging; Animals; Carrier Proteins; Gene Expression Regulation; Inflammasomes; Male; Melatonin; Mice; | 2016 |
Melatonin: resetting the clock of cancer progression?
Topics: Aging; Circadian Clocks; Gene Expression; Humans; Melatonin; Neoplasms; Work Schedule Tolerance | 2016 |
[EFFECT OF MELATONIN ON AGE-RELATED DYNAMICS OF THE REACTIVE PROPERTIES OF BONE TISSUE].
Topics: Age Factors; Aging; Animals; Antioxidants; Bone Density; Bone Density Conservation Agents; Drug Admi | 2015 |
Melatonin administration reverses the alteration of amyloid precursor protein-cleaving secretases expression in aged mouse hippocampus.
Topics: ADAM10 Protein; Aging; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals | 2016 |
The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain.
Topics: Aging; Animals; Antioxidants; Cell Proliferation; Chronic Disease; Cytokines; Drugs, Chinese Herbal; | 2016 |
Presence of photoperiod-melatonin-induced, sexually-activated rams in spring advances puberty in autumn-born ewe lambs.
Topics: Aging; Animals; Drug Implants; Estrous Cycle; Female; Male; Melatonin; Photoperiod; Sexual Maturatio | 2016 |
Aging and Oxidative Stress Decrease Pineal Elongation Factor 2: In Vivo Protective Effect of Melatonin in Young Rats Treated With Cumene Hydroperoxide.
Topics: Aging; Animals; Benzene Derivatives; Eukaryotic Initiation Factor-2; Lipid Peroxidation; Male; Melat | 2017 |
[Sleep Disturbances in the Elderly].
Topics: Aged; Aged, 80 and over; Aging; Cataract; Circadian Rhythm; Humans; Melatonin; Sleep Apnea Syndromes | 2016 |
Effect of long-term treatment with melatonin on vascular markers of oxidative stress/inflammation and on the anticontractile activity of perivascular fat in aging mice.
Topics: Aging; Animals; Aorta; Biomarkers; Inflammation; Intra-Abdominal Fat; Male; Melatonin; Mice; Oxidati | 2017 |
Daily NO rhythms in peripheral clocks in aging male Wistar rats: protective effects of exogenous melatonin.
Topics: Aging; Animals; Biological Clocks; Circadian Rhythm; Male; Melatonin; Nitric Oxide; Rats; Rats, Wist | 2016 |
Physiological and Biochemical Mechanisms of Lifespan Regulation in Rats Kept Under Various Light Conditions.
Topics: Aging; Animals; Antioxidants; Darkness; Female; Light; Liver; Longevity; Male; Melatonin; Rats; Reac | 2017 |
Association of urinary melatonin levels and aging-related outcomes in older men.
Topics: Aged; Aging; Cardiovascular Diseases; Cognition; Cohort Studies; Humans; Male; Melatonin; Mortality; | 2016 |
Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice.
Topics: Aging; Animals; Apoptosis; Catalase; Female; Fertility; Forkhead Box Protein O3; Granulosa Cells; Me | 2016 |
2',3'-Cyclic nucleotide 3'-phosphodiesterase as a messenger of protection of the mitochondrial function during melatonin treatment in aging.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Aging; Animals; Antioxidants; Calcium; Cyclic AMP; Cyt | 2017 |
Long-term melatonin treatment delays ovarian aging.
Topics: Aging; Animals; Antioxidants; Female; Fertility; Melatonin; Mice; Mice, Inbred ICR; Models, Animal; | 2017 |
Anti‑aging effects of melatonin on the myocardial mitochondria of rats and associated mechanisms.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aging; Animals; Antioxidants | 2017 |
Melatonin implantation improved the egg-laying rate and quality in hens past their peak egg-laying age.
Topics: Aging; Animals; Avian Proteins; Chickens; Female; Gene Expression Regulation; Melatonin; Ovum | 2016 |
Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats.
Topics: Aging; Animals; Behavior, Animal; Human Growth Hormone; Humans; Immobilization; Male; Maze Learning; | 2016 |
Melatonin alleviates lipopolysaccharide-compromised integrity of blood-brain barrier through activating AMP-activated protein kinase in old mice.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Blood-Brain Barrier; Cell Line; Enzyme Activation; Li | 2017 |
Pupillary responses to short-wavelength light are preserved in aging.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Circadian Rhythm; Female; Humans; Lens, Crystall | 2017 |
Protective roles of nanomelatonin in cerebral ischemia-reperfusion of aged brain: Matrixmetalloproteinases as regulators.
Topics: Aging; Animals; Antioxidants; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Female; M | 2017 |
Decreased MT1 and MT2 melatonin receptor expression in extrapineal tissues of the rat during physiological aging.
Topics: Aging; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Gene Expression; Liver; Mal | 2009 |
Seasonal changes in circadian peripheral plasma concentrations of melatonin, serotonin, dopamine and cortisol in aged horses with Cushing's disease under natural photoperiod.
Topics: Aging; Animals; Case-Control Studies; Circadian Rhythm; Dopamine; Horses; Hydrocortisone; Melatonin; | 2008 |
[Melatonin, aging and tumors of the prostate].
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Aging; Humans; Immunohistochemistry; Male; Melatonin | 2008 |
[Pineal gland and extrapineal melatonin in visceral organs during natural human aging].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Humans; Immunohistochemistry; Male; Melatonin; Mi | 2008 |
[Extrapineal melatonin in processes of accelerated and premature aging in rats].
Topics: Aging; Aging, Premature; Animals; Disease Models, Animal; Duodenum; Enterochromaffin Cells; Gamma Ra | 2008 |
Melatonin is able to prevent the liver of old castrated female rats from oxidative and pro-inflammatory damage.
Topics: Aging; Animals; Blotting, Western; Female; Heme Oxygenase-1; Inflammation; Interleukins; Lipid Perox | 2008 |
[The bone tissue remodeling in young and adult rats in conditions of alimentary deprivation].
Topics: Aging; Alkaline Phosphatase; Animals; Body Weight; Bone and Bones; Bone Remodeling; Caloric Restrict | 2008 |
[Pineal mechanism of danggui shaoyao powder on anti-aging].
Topics: Aging; Animals; Drugs, Chinese Herbal; Learning; Melatonin; Memory; Pineal Gland; Powders; Rats | 2008 |
Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model.
Topics: Aging; Aging, Premature; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Analysis of Va | 2008 |
Exogenous melatonin decreases age-induced lipid peroxidation in the brain.
Topics: Aging; Animals; Antioxidants; Brain; Glutathione; Lipid Peroxidation; Male; Malondialdehyde; Melaton | 2008 |
Melatonin prevents age-related mitochondrial dysfunction in rat brain via cardiolipin protection.
Topics: Aging; Animals; Brain; Cardiolipins; Electron Transport Complex I; Energy Metabolism; Hydrogen Perox | 2008 |
Melatonin attenuates the decrement of dendritic protein MAP-2 immuno-staining in the hippocampal CA1 and CA3 fields of the aging male rat.
Topics: Aging; Animals; Antioxidants; Down-Regulation; Hippocampus; Male; Melatonin; Microtubule-Associated | 2008 |
Chronic treatment with melatonin attenuates serotonergic degeneration in the striatum and olfactory tubercle of zitter mutant rats.
Topics: Aging; Animals; Antioxidants; Chromatography, High Pressure Liquid; Corpus Striatum; Immunohistochem | 2008 |
Expression profiles of PERIOD1, 2, and 3 in peripheral blood mononuclear cells from older subjects.
Topics: Aged; Aging; Cell Cycle Proteins; Circadian Rhythm; Gene Expression Profiling; Humans; Leukocytes, M | 2009 |
[Age aspects of clinical-morphological characteristics and treatment of duodenal ulcer].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Duodenal Ulcer; Endothelin-1; Gastric Mucosa; Hel | 2008 |
Melatonin and tryptophan affect the activity-rest rhythm, core and peripheral temperatures, and interleukin levels in the ringdove: changes with age.
Topics: Administration, Oral; Aging; Animals; Body Temperature Regulation; Circadian Rhythm; Columbidae; Fem | 2009 |
Age-related changes in acute and phase-advancing responses to monochromatic light.
Topics: Adult; Affect; Age Factors; Aged; Aging; Biological Clocks; Circadian Rhythm; Humans; Light; Male; M | 2009 |
Age-related changes in melatonin synthesis in rat extrapineal tissues.
Topics: Acetylserotonin O-Methyltransferase; Aging; Animals; Arylalkylamine N-Acetyltransferase; Enzyme-Link | 2009 |
Improvement of leucocyte functions in ovariectomised aged rats after treatment with growth hormone, melatonin, oestrogens or phyto-oestrogens.
Topics: Age Factors; Aging; Animals; Cell Proliferation; Chemotaxis; Concanavalin A; Cytotoxicity, Immunolog | 2009 |
[The influences of geroprotectors on age-related changes of antioxidant system in rats liver under different light condition].
Topics: Aging; Animals; Antioxidants; Female; Liver; Male; Melatonin; Oligopeptides; Photoperiod; Rats; Seas | 2008 |
[The influence of melatonin and epithalon on blood leukocyte count and leukocyte alkaline phosphatase in rats under different lighting conditions during ontogenesis].
Topics: Aging; Alkaline Phosphatase; Animals; Female; Leukocyte Count; Leukocytes; Male; Melatonin; Oligopep | 2008 |
The timing of the shrew: continuous melatonin treatment maintains youthful rhythmic activity in aging Crocidura russula.
Topics: Aging; Animals; Circadian Rhythm; Female; Male; Melatonin; Models, Biological; Models, Statistical; | 2009 |
An unexpected effect of 5-MCA-NAT in chick retinal development.
Topics: Aging; Animals; Binding Sites; Chick Embryo; Chickens; Colforsin; Cyclic AMP; Dose-Response Relation | 2009 |
Effect of melatonin and tryptophan on humoral immunity in young and old ringdoves (Streptopelia risoria).
Topics: Administration, Oral; Aging; Animals; Columbidae; Female; Immunity, Humoral; Male; Melatonin; Trypto | 2009 |
[The role of melatonin in the development of metabolic syndrome].
Topics: Aged; Aged, 80 and over; Aging; Circadian Rhythm; Disease Progression; Female; Humans; Male; Melaton | 2009 |
Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor.
Topics: Adaptation, Biological; Aging; Animals; Cell Survival; Darkness; Electroretinography; Gene Expressio | 2009 |
Urinary 6-sulfatoxymelatonin level in age-related macular degeneration patients.
Topics: Aged; Aging; Case-Control Studies; Creatinine; Demography; Female; Humans; Macular Degeneration; Mal | 2009 |
MT2 melatonin receptor immunoreactivity in neurons is very high in the aged hippocampal formation in gerbils.
Topics: Aging; Animals; Gerbillinae; Hippocampus; Male; Melatonin; Neurons; Receptor, Melatonin, MT2 | 2010 |
Effect of melatonin on age induced changes in daily serotonin rhythms in suprachiasmatic nucleus of male Wistar rat.
Topics: Aging; Animals; Fluorometry; Male; Melatonin; Periodicity; Rats; Rats, Wistar; Serotonin; Suprachias | 2010 |
The role of melatonin on gastric mucosal cell proliferation and telomerase activity in ageing.
Topics: Aging; Animals; Cell Cycle; Cell Line; Cell Proliferation; Central Nervous System Depressants; Gastr | 2009 |
The ultrastructural and biochemical evidences of the beneficial effects of chronic caffeic acid phenethyl ester and melatonin administration on brain and cerebellum of aged rats.
Topics: Aging; Animals; Brain; Caffeic Acids; Cerebellum; Cerebrum; Drug Administration Schedule; Male; Mela | 2010 |
[The evolutionary role of nitric oxide in circadian activity and defense of the organism from cosmic rays].
Topics: Adaptation, Physiological; Aging; Animals; Biological Evolution; Circadian Rhythm; Cosmic Radiation; | 2009 |
New data on biochemical mechanism of programmed senescence of organisms and antioxidant defense of mitochondria.
Topics: Aging; Antioxidants; Melatonin; Mitochondria; Reactive Oxygen Species | 2009 |
Melatonin causes gene expression in aged animals to respond to inflammatory stimuli in a manner differing from that of young animals.
Topics: Aging; Animals; Brain; Gene Expression; Inflammation; Lipopolysaccharides; Male; Melatonin; Mice; Mi | 2008 |
Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain.
Topics: Aging; Animals; Antioxidants; Behavior, Animal; Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopa | 2010 |
Melatonin counteracts alterations in oxidative metabolism and cell viability induced by intracellular calcium overload in human leucocytes: changes with age.
Topics: Adult; Aged; Aging; Antioxidants; Calcium; Cell Survival; Enzyme Inhibitors; Female; Humans; Hydroge | 2010 |
Increased susceptibility to Ca(2+)-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: effect of melatonin.
Topics: Aging; Analysis of Variance; Animals; Calcium; Cardiolipins; Cytochromes c; Male; Melatonin; Membran | 2010 |
[The morphological response of the pineal gland of old animals on course of melatonin injections].
Topics: Aging; Animals; Apoptosis; Cell Nucleus; Dose-Response Relationship, Drug; Male; Melatonin; Pineal G | 2009 |
[Effect of preparations melatonin and epitalon on the age-related dynamics of thyrotrophic activity of the hypophysis and thyroid gland function in different light regimes].
Topics: Aging; Animals; Circadian Rhythm; Female; Light; Male; Melatonin; Oligopeptides; Pituitary Gland; Ra | 2009 |
Melatonin alters age-related changes in transcription factors and kinase activation.
Topics: Aging; Animals; Blotting, Western; Brain; Electrophoretic Mobility Shift Assay; Enzyme Activation; I | 2010 |
Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats.
Topics: Aging; Animals; Estrogens; Female; Glutathione; Glutathione Disulfide; Growth Hormone; Humans; Kidne | 2010 |
Neuroendocrine-immune interactions in healthy aging.
Topics: Adrenal Glands; Adult; Aged; Aging; Antigens, CD20; B-Lymphocytes; Follow-Up Studies; Humans; Hydroc | 2011 |
Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging.
Topics: Aging; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Heart; Heme Oxygenase (Decyclizing) | 2010 |
Sleep in older adults with Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Caregivers; Causality; Exercise; Family; Geriatric Assessment; Human | 2010 |
Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8).
Topics: Aging; Animals; Antioxidants; Chemokine CCL2; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hepati | 2010 |
Extended exposure to dietary melatonin reduces tumor number and size in aged male mice.
Topics: Aging; Animal Feed; Animals; Antioxidants; Chimera; Incidence; Male; Melatonin; Mice; Mice, Inbred B | 2011 |
The effects of caffeic acid phenethyl ester and melatonin on age-related vascular remodeling and cardiac damage.
Topics: Aging; Animals; Antioxidants; Aorta; Caffeic Acids; Catalase; Disease Models, Animal; Drug Evaluatio | 2011 |
Diurnal expression of clock genes in pineal gland and brain and plasma levels of melatonin and cortisol in Atlantic salmon parr and smolts.
Topics: Actins; Aging; Animals; Biological Clocks; Brain; Circadian Rhythm; CLOCK Proteins; Cryptochromes; G | 2010 |
Melatonin induces neural SOD2 expression independent of the NF-kappaB pathway and improves the mitochondrial population and function in old mice.
Topics: Aging; Animals; Antioxidants; Blotting, Western; Female; In Vitro Techniques; Male; Melatonin; Membr | 2011 |
[Effect of thymic factor on oxygen free radical and antioxidans in old male rats].
Topics: Aging; Animals; Catalase; Circadian Rhythm; Free Radicals; Lipid Peroxides; Male; Melatonin; Nitric | 2003 |
Antioxidant system and energy provision of the rat heart during aging depend on illumination regimen and are resistant to exogenous melatonin.
Topics: Age Factors; Aging; Animals; Chromatography, High Pressure Liquid; Energy Metabolism; Female; Heart; | 2010 |
The study of melatonin protective activity on pancreatic β-cells under the condition of alloxan-induced diabetes during aging.
Topics: Age Factors; Aging; Animals; Antioxidants; Diabetes Mellitus, Experimental; Insulin-Secreting Cells; | 2010 |
Melatonin decreases apoptosis in gastric mucosa during aging.
Topics: Age Factors; Aging; Animals; Antioxidants; Apoptosis; Caspase 3; Gastric Mucosa; Lipid Peroxidation; | 2012 |
Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta.
Topics: Aging; Animals; Circadian Clocks; Circadian Rhythm; Longitudinal Studies; Macaca mulatta; Male; Mela | 2011 |
[Pineal gland melatonin-producing function in elderly patients with hypertensive disease: age peculiarities].
Topics: Adult; Age Factors; Aged; Aging; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Circadian Rh | 2010 |
Sex difference in the near-24-hour intrinsic period of the human circadian timing system.
Topics: Adolescent; Adult; Aged; Aging; Body Temperature; Circadian Clocks; Female; Humans; Male; Melatonin; | 2011 |
Melatonin protects lung mitochondria from aging.
Topics: Adenosine Triphosphate; Administration, Oral; Aging; Animals; Antioxidants; Disease Models, Animal; | 2012 |
Effect of a combined treatment with growth hormone and melatonin in the cardiological aging on male SAMP8 mice.
Topics: Administration, Oral; Aging; Animals; Apoptosis; Biomarkers; Cell Nucleus; Cytosol; Drug Administrat | 2011 |
Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anxiety; Basal Nucleus of Meynert | 2011 |
Aging impairs Ca2+ sensitization pathways in gallbladder smooth muscle.
Topics: Aging; Amides; Analysis of Variance; Animals; Bethanechol; Blotting, Western; Calcium Channels; Calc | 2012 |
[Influence of the pineal gland's factors on the cell composition of the bone marrow in animals of different age in conditions of changed thymus functional state].
Topics: Aging; Animals; Bone Marrow Cells; CD4-Positive T-Lymphocytes; Fibroblasts; Granulocyte-Macrophage P | 2011 |
Amelioration of age-dependent increase in protein carbonyls of cerebral hemispheres of mice by melatonin and ascorbic acid.
Topics: Aging; Animals; Ascorbic Acid; Brain; Female; Melatonin; Mice; Mice, Inbred BALB C; Nerve Tissue Pro | 2011 |
Older poor-sleeping women display a smaller evening increase in melatonin secretion and lower values of melatonin and core body temperature than good sleepers.
Topics: Adult; Aged; Aged, 80 and over; Aging; Body Temperature; Circadian Rhythm; Cross-Sectional Studies; | 2011 |
Correlation between plasma levels of radical scavengers and hearing threshold among elderly subjects with age-related hearing loss.
Topics: Aged; Aged, 80 and over; Aging; Ascorbic Acid; Auditory Threshold; Cross-Sectional Studies; Female; | 2011 |
Aging and vascular dysfunction: beneficial melatonin effects.
Topics: Aging; Animals; Antioxidants; Atherosclerosis; Cells, Cultured; Disease Models, Animal; Endothelium, | 2013 |
Short wavelength light filtering by the natural human lens and IOLs -- implications for entrainment of circadian rhythm.
Topics: Adolescent; Adult; Aged; Aging; Circadian Rhythm; Filtration; Humans; Lens, Crystalline; Lenses, Int | 2013 |
Aging-induced alterations in female rat colon smooth muscle: the protective effects of hormonal therapy.
Topics: Aging; Animals; Caspase 3; Caspase 9; Catalase; Colon; Cyclooxygenase 2; Estradiol; Estrogen Replace | 2012 |
[Effect of melatonin on glial fibrillary acidic protein, nuclear factor-kB and synaptophysin expressions in aging mice].
Topics: Aging; Animals; Brain; Chimera; Glial Fibrillary Acidic Protein; Male; Melatonin; Mice; Mice, Inbred | 2011 |
[Cellular aspects of aging in the pineal gland of the shrew, Crocidura russula].
Topics: Aging; Animals; Biological Clocks; Cell Nucleus; Endoplasmic Reticulum; Melatonin; Microscopy, Elect | 2012 |
Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8).
Topics: Aging; Animals; Antioxidants; Follow-Up Studies; Gene Expression Regulation, Developmental; Glucagon | 2013 |
Functional unity of the thymus and pineal gland and study of the mechanisms of aging.
Topics: Adaptive Immunity; Age Factors; Aging; Humans; Melatonin; Pineal Gland; Serotonin; Thymus Gland | 2011 |
Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans.
Topics: Affect; Aged; Aging; Antioxidants; Circadian Rhythm; Edible Grain; Female; Humans; Male; Melatonin; | 2013 |
Age-related changes in the daily rhythm of photoreceptor functioning and circuitry in a melatonin-proficient mouse strain.
Topics: Aging; Animals; Circadian Rhythm; Electroretinography; Melatonin; Mice; Mice, Knockout; Photorecepto | 2012 |
Does pupil constriction under blue and green monochromatic light exposure change with age?
Topics: Adult; Age Factors; Aged; Aging; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Middle Ag | 2012 |
Age-related changes in the rat brain mitochondrial antioxidative enzyme ratios: modulation by melatonin.
Topics: Aging; Animals; Antioxidants; Brain; Glutathione Peroxidase; Glutathione Reductase; Male; Melatonin; | 2012 |
Not only melatonin but also caffeic acid phenethyl ester protects kidneys against aging-related oxidative damage in Sprague Dawley rats.
Topics: Aging; Animals; Antioxidants; Caffeic Acids; Cytoprotection; Kidney; Male; Melatonin; Oxidative Stre | 2012 |
Melatonin administration differentially affects age-induced alterations in daily rhythms of lipid peroxidation and antioxidant enzymes in male rat liver.
Topics: Aging; Animals; Antioxidants; Catalase; Glutathione Peroxidase; Lipid Peroxidation; Liver; Male; Mel | 2012 |
Melatonin supplementation delays the decline of adult hippocampal neurogenesis during normal aging of mice.
Topics: Aging; Animals; Cell Proliferation; Cell Survival; Central Nervous System Depressants; Cognition; De | 2012 |
Long-term exogenous application of melatonin delays drought-induced leaf senescence in apple.
Topics: Aging; Analysis of Variance; Antioxidants; Chlorophyll; Droughts; Malus; Melatonin; Oxygenases; Plan | 2013 |
Improvement of oxidative stress and immunity by melatonin: an age dependent study in golden hamster.
Topics: Age Factors; Aging; Animals; Bone Marrow; Catalase; Cell Cycle; Cell Proliferation; Cells, Cultured; | 2013 |
Light-at-night-induced circadian disruption, cancer and aging.
Topics: Age Factors; Aging; Animals; Anticarcinogenic Agents; Blindness; Cell Transformation, Neoplastic; Ci | 2012 |
Melatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats.
Topics: 1,2-Dimethylhydrazine; Age Factors; Aging; Aging, Premature; Animals; Circadian Rhythm; Dopamine; Es | 2012 |
Ovarian aging: melatonin regulation of the cytometric and endocrine evolutive pattern.
Topics: Aging; Animals; Cell Count; Cell Cycle; Estradiol; Estrus; Female; Flow Cytometry; Ki-67 Antigen; Me | 2013 |
[The melatonin influences on neutrophils/lymphocytes ratio of mammals blood depends on age of animals].
Topics: Aging; Animals; Dogs; Female; Foxes; Leukocyte Count; Light; Lymphocytes; Male; Melatonin; Neutrophi | 2012 |
Factors regulating the influence of melatonin on hippocampal evoked potentials: comparative studies on different strains of mice.
Topics: Aging; Animals; Circadian Rhythm; Evoked Potentials; Female; Hippocampus; In Vitro Techniques; Light | 2002 |
No association of 6-sulfatoxymelatonin with in-bed 60-Hz magnetic field exposure or illumination level among older adults.
Topics: Aged; Aged, 80 and over; Aging; Biomarkers; Electromagnetic Fields; Environmental Exposure; Female; | 2002 |
Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin.
Topics: Age Factors; Aging; Animals; Female; Liver; Melatonin; Ovary; Peptides; Rats; Rats, Wistar; Spleen; | 2002 |
Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice.
Topics: Aging; Animals; Bone Marrow Cells; Chromosome Aberrations; Female; Melatonin; Mice; Oligopeptides | 2002 |
Syrian hamster and rat display developmental differences in the regulation of pineal arylalkylamine N-acetyltransferase.
Topics: Adrenergic Antagonists; Aging; Animals; Animals, Newborn; Arylamine N-Acetyltransferase; Circadian R | 2002 |
Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Body Weight; Cerebral Cortex; Down-Regulation; Encephalitis; Explor | 2002 |
Aging and the circadian rhythm of melatonin: a cross-sectional study of Chinese subjects 30-110 yr of age.
Topics: Adult; Aged; Aged, 80 and over; Aging; China; Circadian Rhythm; Cross-Sectional Studies; Female; Hum | 2002 |
Acutely administered melatonin restores hepatic mitochondrial physiology in old mice.
Topics: Aging; Animals; Antioxidants; Cellular Senescence; Electron Transport; Female; Free Radicals; Liver; | 2003 |
Suppression of hypothalamic pro-opiomelanocortin (POMC) gene expression by daily melatonin supplementation in aging rats.
Topics: Aging; Animals; Body Weight; Gene Expression Regulation; In Situ Hybridization; Male; Melatonin; Pro | 2003 |
Circadian phase-shifting effects of nocturnal exercise in older compared with young adults.
Topics: Adult; Aged; Aging; Body Temperature; Circadian Rhythm; Darkness; Exercise; Female; Humans; Male; Me | 2003 |
Age, lens transmittance, and the possible effects of light on melatonin suppression.
Topics: Aging; Circadian Rhythm; Cornea; Humans; Lens, Crystalline; Melatonin; Pupil; Retina | 2003 |
Melatonin counteracts lipopolysaccharide-induced expression and activity of mitochondrial nitric oxide synthase in rats.
Topics: Aging; Animals; Electron Transport Complex I; Electron Transport Complex IV; Enzyme Activation; Enzy | 2003 |
Modification of the uterotropic effect produced by estrogens in aging rats.
Topics: Acetylcysteine; Aging; Animals; Ascorbic Acid; Carnosine; DNA Damage; Endometrium; Estradiol; Female | 2002 |
Effect of a synthetic pineal tetrapeptide (Ala-Glu-Asp-GLy) on melatonin secretion by the pineal gland of young and old rats.
Topics: Adrenergic beta-Agonists; Aging; Animals; In Vitro Techniques; Isoproterenol; Male; Melatonin; Oligo | 2003 |
Melatonin-induced reduction in age-related accumulation of oxidative damage in mice.
Topics: Aging; Animals; Body Weight; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Lipid Pero | 2003 |
Melatonin rejuvenates degenerated thymus and redresses peripheral immune functions in aged mice.
Topics: Aging; Animals; Cell Count; Cell Division; Cells, Cultured; Female; Killer Cells, Natural; Melatonin | 2003 |
Age-related changes of circadian rhythms and sleep-wake cycles.
Topics: Adolescent; Adult; Aged; Aging; Circadian Rhythm; Female; Humans; Hydrocortisone; Male; Melatonin; M | 2003 |
Transgenic TGR(mREN2)27 rats as a model for disturbed circadian organization at the level of the brain, the heart, and the kidneys.
Topics: Aging; Animals; Animals, Genetically Modified; Blood Pressure; Body Temperature; Brain; Circadian Rh | 2003 |
Diel changes in plasma melatonin and corticosterone concentrations in tropical Nazca boobies (Sula granti) in relation to moon phase and age.
Topics: Aging; Animals; Animals, Wild; Birds; Circadian Rhythm; Corticosterone; Ecuador; Melatonin; Models, | 2003 |
Stability of sleep timing against the melatonin secretion rhythm with advancing age: clinical implications.
Topics: Aged; Aging; Circadian Rhythm; Female; Humans; Lighting; Male; Melatonin; Middle Aged; Pineal Gland; | 2003 |
Restless nights, listless days.
Topics: Adolescent; Adult; Aged; Aging; Alzheimer Disease; Biological Clocks; Circadian Rhythm; Darkness; Hu | 2003 |
Unravelling the role of pineal gland.
Topics: Aging; Circadian Rhythm; Female; Humans; Melatonin; Menstruation; Pineal Gland; Sleep | 2003 |
[Investigation, treatment and monitoring of late-onset hypogonadism in males: the official guidelines of the International Society for the Study of the Study of the Aging Male (ISSAM) with comments].
Topics: Aging; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; France; Hormones; Human Gr | 2003 |
Impact of treatment with melatonin on cerebral circulation in old rats.
Topics: Aging; Animals; Arterioles; Brain; Cerebrovascular Circulation; Hypotension; Male; Melatonin; Rats; | 2004 |
[Regulating effect of pineal gland peptides on development of T-lymphocytes in CBA aging mice: role of microenvironment of immune system organs and neuroendocrine factors].
Topics: Aging; Animals; Biogenic Monoamines; Bone Marrow; Cell Differentiation; Cell Division; Cell Movement | 2003 |
[Peptide correction of age-related pineal disturbances in monkeys].
Topics: Aging; Animals; Circadian Rhythm; Female; Injections, Intramuscular; Macaca mulatta; Melatonin; Olig | 2003 |
Age-related changes in murine CNS mRNA gene expression are modulated by dietary melatonin.
Topics: Aging; Animals; Central Nervous System; Diet; Gene Expression Regulation; Male; Melatonin; Mice; Mic | 2004 |
Age-related changes in serum melatonin in mice: higher levels of combined melatonin and 6-hydroxymelatonin sulfate in the cerebral cortex than serum, heart, liver and kidney tissues.
Topics: Aging; Animals; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Kidney; Liver; Male; Melatonin; | 2004 |
Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex.
Topics: Aging; Amyloid beta-Peptides; Animals; Antioxidants; Blotting, Western; Cerebral Cortex; Dietary Sup | 2004 |
Qualitative and quantitative changes of melatonin levels in physiological and pathological aging and in centenarians.
Topics: Adult; Aged; Aged, 80 and over; Aging; Circadian Rhythm; Female; Humans; Male; Melatonin; Neurodegen | 2004 |
[Switching off the estrogen effect and approaches to its correction].
Topics: Acetylcysteine; Aging; Animals; Antioxidants; Ascorbic Acid; Carnosine; Cell Cycle; DNA Damage; Estr | 2003 |
A quantitative model of cellular senescence influence on cancer and longevity.
Topics: Aging; Animals; Antioxidants; Cellular Senescence; Female; Genes, p53; Longevity; Melatonin; Mice; M | 2002 |
Short day lengths delay reproductive aging.
Topics: Aging; Animals; Cricetinae; Female; Male; Melatonin; Phodopus; Photoperiod; Pineal Gland; Pregnancy; | 2004 |
Aging and vestibular system: specific tests and role of melatonin in cognitive involvement.
Topics: Accidental Falls; Aged; Aged, 80 and over; Aging; Cerebellum; Chronobiology Disorders; Cognition Dis | 2004 |
Ex vivo studies on the acute and chronic effects of DHEA and DHEA-sulfate on melatonin synthesis in young- and old-rat pineal glands.
Topics: Acetylserotonin O-Methyltransferase; Aging; Animals; Arylamine N-Acetyltransferase; Darkness; Dehydr | 2004 |
Age-related endocrine dysfunction in nonhuman primates.
Topics: Aging; Animals; Corticotropin-Releasing Hormone; Endocrine System; Female; Hormones; Hydrocortisone; | 2004 |
Secretion of melatonin in healthy elderly subjects: a longitudinal study.
Topics: Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Area Under Curve; Female; Humans; Male; | 2004 |
Postoperative delirium: the tryptophan dyregulation model.
Topics: Aged; Aged, 80 and over; Aging; Brain; Delirium; Humans; Melatonin; Models, Neurological; Postoperat | 2004 |
Pineal attrition, loss of cognitive plasticity, and onset of puberty during the teen years: is it a modern maladaptation exposed by evolutionary displacement?
Topics: Adolescent; Adult; Aging; Cognition; Cognition Disorders; Gene Expression Regulation, Developmental; | 2004 |
The effect of melathonin on changes in brown and white adipose tissue ratios induced by exercise. The significance of age in this effect.
Topics: Adipose Tissue; Adipose Tissue, Brown; Aging; Animals; Body Composition; Injections, Intraperitoneal | 2004 |
Influence of age on the relationship between annual changes in horn growth rate and prolactin secretion in the European mouflon (Ovis gmelini musimon).
Topics: Aging; Animals; Horns; Male; Melatonin; Prolactin; Seasons; Sheep, Domestic; Testis | 2005 |
Declining melatonin levels and older people. How old is old?
Topics: Aged; Aged, 80 and over; Aging; Analysis of Variance; Cohort Studies; Humans; Melatonin; Middle Aged | 2004 |
[Circadian rhythms of pineal gland melatonin-forming function in healthy elderly people].
Topics: Aged; Aging; Body Temperature; Circadian Rhythm; Humans; Melatonin; Middle Aged; Photoperiod; Pineal | 2004 |
Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials.
Topics: Aging; Amyloid beta-Peptides; Animals; Antioxidants; Astrocytes; Lipid Peroxidation; Melatonin; Mice | 2005 |
Effect of melatonin administration on parameters related to oxidative damage in hepatocytes isolated from old Wistar rats.
Topics: Aging; Animals; Cells, Cultured; Hepatocytes; Lipid Peroxidation; Melatonin; Oxidative Stress; Rats; | 2005 |
Protective effects of melatonin against ethanol-induced reactive gliosis in hippocampus and cortex of young and aged rats.
Topics: Age Factors; Aging; Alcohol-Induced Disorders, Nervous System; Animals; Biomarkers; Cerebral Cortex; | 2005 |
[Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].
Topics: Aging; Animals; Cell Transformation, Neoplastic; Female; Life Expectancy; Melatonin; Mice; Oligopept | 2005 |
Old rats are more sensitive to photoperiodic changes. A study on pineal melatonin.
Topics: Adrenergic beta-Agonists; Aging; Animals; Isoproterenol; Male; Melatonin; Photoperiod; Pineal Gland; | 2005 |
Melatonin, lipid peroxidation, and age in heterophils from the ring dove (Streptopelia risoria).
Topics: Aging; Animals; Columbidae; Female; Lipid Peroxidation; Male; Melatonin | 2005 |
Age-associated changes in protein oxidation and proteasome activities in rat brain: modulation by antioxidants.
Topics: Aging; Animals; Antioxidants; Brain; Coenzymes; Enzyme Activation; Lipofuscin; Male; Melatonin; Nerv | 2005 |
Circadian phase in adults of contrasting ages.
Topics: Adult; Aged; Aging; Body Temperature; Circadian Rhythm; Humans; Hydrocortisone; Melatonin; Middle Ag | 2005 |
Potent therapeutic effect of melatonin on aging skin in pinealectomized rats.
Topics: Aging; Animals; Catalase; Glutathione Peroxidase; Male; Malondialdehyde; Melatonin; Oxidative Stress | 2005 |
Age-related attenuation of the evening circadian arousal signal in humans.
Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Arousal; Circadian Rhythm; Electroencephalogr | 2005 |
[Age-related characteristics of the melatonin-producing epiphyseal function in CBA mice immunized by T-dependent antigen].
Topics: Aging; Animals; Antigens; Corticosterone; Female; Immunization; Melatonin; Mice; Mice, Inbred CBA; P | 2005 |
Comparison of the impact of melatonin on chronic ethanol-induced learning and memory impairment between young and aged rats.
Topics: Aging; Animals; Avoidance Learning; Brain; Escape Reaction; Ethanol; Glutathione; Learning; Lipid Pe | 2005 |
The effects of periodic alteration of the temperature on the rhythmic melatonin release of explanted chicken pineals.
Topics: Aging; Animals; Chickens; Darkness; Female; Light; Male; Melatonin; Organ Culture Techniques; Perfus | 2005 |
Age-related changes in circadian rhythm of serotonin synthesis in ring doves: effects of increased tryptophan ingestion.
Topics: Aging; Animals; Circadian Rhythm; Columbidae; Corpus Striatum; Hippocampus; Hypothalamus; Melatonin; | 2006 |
Metallothionein-I-II expression in young and adult bovine pineal gland.
Topics: Aging; Animals; Cattle; Chromatography, High Pressure Liquid; Glial Fibrillary Acidic Protein; Hydro | 2006 |
Responsiveness of the aging circadian clock to light.
Topics: Adaptation, Physiological; Adult; Aged; Aging; Circadian Rhythm; Female; Humans; Male; Melatonin; Mi | 2006 |
The rotational origin and state of the whole: its relation to growth, fertility, aging, death, and diseases.
Topics: Aging; Animals; Biological Clocks; Cell Transplantation; Death; Disease; Fertility; Growth; Humans; | 2005 |
From molecular biology to anti-aging cognitive-behavioral practices: the pioneering research of Walter Pierpaoli on the pineal and bone marrow foreshadows the contemporary revolution in stem cell and regenerative biology.
Topics: Adult; Aging; Animals; Bone Marrow Cells; Diet; Exercise; Humans; Life Expectancy; Meditation; Melat | 2005 |
Melatonin influences on the neuroendocrine-reproductive axis.
Topics: Aging; Animals; Circadian Rhythm; Feedback, Physiological; Female; Follicle Stimulating Hormone; Gon | 2005 |
Clinical perspectives for the use of melatonin as a chronobiotic and cytoprotective agent.
Topics: Aging; Animals; Biological Clocks; Chronobiology Disorders; Circadian Rhythm; Dementia; Humans; Mela | 2005 |
Inverse correlation between endogenous melatonin levels and oxidative damage in some tissues of SAM P8 mice.
Topics: Aging; Animals; Antioxidants; Lipid Peroxidation; Liver; Male; Melatonin; Mice; Protein Carbonylatio | 2006 |
Correlation of serum trace elements and melatonin levels to radiological, biochemical, and histological assessment of degeneration in patients with intervertebral disc herniation.
Topics: Adult; Aged; Aging; Calcinosis; Collagen; Data Interpretation, Statistical; Female; Humans; Hydroxyp | 2006 |
Exploratory investigation of the effect of melatonin and caloric restriction on the temporal expression of murine hypothalamic transcripts.
Topics: Aging; Animals; Biological Clocks; Caloric Restriction; Circadian Rhythm; E-Box Elements; Gene Expre | 2006 |
Age related changes in the activity-rest circadian rhythms and c-fos expression of ring doves with aging. Effects of tryptophan intake.
Topics: Activity Cycles; Aging; Animals; Body Temperature Regulation; Circadian Rhythm; Columbidae; Gene Exp | 2006 |
Normative data on the daily profile of urinary 6-sulfatoxymelatonin in healthy subjects between the ages of 20 and 84.
Topics: Adult; Aged; Aged, 80 and over; Aging; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Age | 2006 |
Physiological pineal effects on female reproductive function of laboratory rats: prenatal development of pups, litter size and estrous cycle in middle age.
Topics: Aging; Animals; Congenital Abnormalities; Estrous Cycle; Female; Litter Size; Maternal Age; Melatoni | 2006 |
Circadian and homeostatic sleep regulation in morningness-eveningness.
Topics: Adult; Aged; Aging; Circadian Rhythm; Female; Habits; Homeostasis; Humans; Male; Melatonin; Middle A | 2006 |
Violet and blue light blocking intraocular lenses: photoprotection versus photoreception.
Topics: Aged; Aging; Child, Preschool; Circadian Rhythm; Eye Protective Devices; Humans; Lens, Crystalline; | 2006 |
Melatonin reduces oxidative stress in erythrocytes and plasma of senescence-accelerated mice.
Topics: Aging; Aging, Premature; Animals; Antioxidants; Erythrocytes; Female; Glutathione; Glutathione Perox | 2006 |
Comparative study of the activity/rest rhythms in young and old ringdove (Streptopelia risoria): correlation with serum levels of melatonin and serotonin.
Topics: Aging; Animals; Circadian Rhythm; Columbidae; Female; Male; Melatonin; Models, Statistical; Motor Ac | 2006 |
Melatonin treatment reverts age-related changes in Guinea pig gallbladder neuromuscular transmission and contractility.
Topics: Acetylcholine; Aging; Animals; Calcium; Female; Gallbladder; Guinea Pigs; Melatonin; Muscle Contract | 2006 |
[Melatonin recovers ischemic tolerance and decreases the sensitivity of mitochondrial permeability transition pore opening in the heart of aging rats].
Topics: Aging; Animals; bcl-2-Associated X Protein; Coronary Circulation; Free Radicals; Injections, Intrape | 2006 |
Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment.
Topics: Aging; Animals; Antioxidants; Endotoxemia; Enzyme Induction; Injections; Kidney Diseases; Lipid Pero | 2006 |
Melatonin treatment in old mice enables a more youthful response to LPS in the brain.
Topics: Aging; Animals; Brain; Dietary Supplements; Drug Synergism; Gene Expression; Injections, Intraperito | 2007 |
Expression of tranferrin receptors in the pineal gland of postnatal and adult rats and its alteration in hypoxia and melatonin treatment.
Topics: Aging; Animals; Animals, Newborn; Cell Differentiation; Cell Membrane; Disease Models, Animal; Hypox | 2007 |
Effect of melatonin on vascular responses in aortic rings of aging rats.
Topics: Acetylcholine; Aging; Animals; Antioxidants; Aorta, Thoracic; Blood Glucose; Dose-Response Relations | 2007 |
Effects of melatonin and age on gene expression in mouse CNS using microarray analysis.
Topics: Acute-Phase Proteins; Aging; Animals; Arylalkylamine N-Acetyltransferase; Central Nervous System; Ge | 2007 |
Loss of responsiveness to melatonin in the aging mouse suprachiasmatic nucleus.
Topics: Age Factors; Aging; Animals; CREB-Binding Protein; Drug Interactions; In Vitro Techniques; Melatonin | 2008 |
[Influence of light regimens, melatonin, and epitalon on amylase activity in the pancreas and small intestine in rats of different age].
Topics: Aging; Amylases; Animals; Female; Intestine, Small; Light; Male; Melatonin; Oligopeptides; Pancreas; | 2006 |
[Effect of age, different light conditions, melatonin, and epitalon on lysosomal proteinase activity in the liver and kidneys of rats].
Topics: Aging; Animals; Female; Kidney; Light; Liver; Lysosomes; Male; Melatonin; Oligopeptides; Peptide Hyd | 2006 |
Effects of ageing and exogenous melatonin on pituitary responsiveness to GnRH in ewes during anestrus and the reproductive season.
Topics: Aging; Anestrus; Animals; Antioxidants; Female; Luteinizing Hormone; Melatonin; Pituitary Gland; Rep | 2007 |
Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice.
Topics: Adenosine Triphosphate; Aging; Animals; Antioxidants; Electron Transport Chain Complex Proteins; Fem | 2007 |
Effect of exogenous administration of melatonin and growth hormone on pro-antioxidant functions of the liver in aging male rats.
Topics: Aging; Animals; Free Radical Scavengers; Free Radicals; Growth Hormone; Liver; Male; Melatonin; Rats | 2007 |
Tryptophan increases nocturnal rest and affects melatonin and serotonin serum levels in old ringdove.
Topics: Aging; Analysis of Variance; Animals; Circadian Rhythm; Columbidae; Dose-Response Relationship, Drug | 2007 |
Dose-dependent inhibitory effect of melatonin on carcinogenesis induced by benzo[a]pyrene in mice.
Topics: Aging; Animals; Autopsy; Benzo(a)pyrene; Carcinogens; Dose-Response Relationship, Drug; Female; Lipi | 2006 |
[Biologically active thymic factors and melatonin-producing pineal function in mice in aging].
Topics: Aging; Animals; Melatonin; Mice; Mice, Inbred CBA; Pineal Gland; Seasons; Thymic Factor, Circulating | 2006 |
Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats.
Topics: Aging; Animals; Antioxidants; Gene Expression; Liver; Male; Melatonin; Oxidative Stress; Rats; Rats, | 2007 |
Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice.
Topics: Aging; Animals; Cytokines; Female; Inflammation; Male; Melatonin; Mice; Nitric Oxide | 2007 |
Orally administered melatonin improves nocturnal rest in young and old ringdoves (Streptopelia risoria).
Topics: Activity Cycles; Administration, Oral; Age Factors; Aging; Animals; Antioxidants; Columbidae; Dose-R | 2007 |
Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish.
Topics: Aging; Animals; beta-Galactosidase; Brain; DNA Damage; Female; Gills; Male; Melatonin; Phenotype; Ra | 2007 |
[Molecular mechanisms of aging and its prevention by hormonal treatment in rats].
Topics: Age Factors; Aging; Animals; Apoptosis; Brain; Castration; Cells, Cultured; Data Interpretation, Sta | 2006 |
Effect of chronic treatments with GH, melatonin, estrogens, and phytoestrogens on oxidative stress parameters in liver from aged female rats.
Topics: Aging; Animals; Antioxidants; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Estrogens; F | 2007 |
Aging impairs neurogenic contraction in guinea pig urinary bladder: role of oxidative stress and melatonin.
Topics: Aging; Animals; Antioxidants; Electric Stimulation; Female; Guinea Pigs; Melatonin; Muscle Contracti | 2007 |
Melatonin and thyroxine response to pollution in white stork nestlings (Ciconia ciconia): aspects of rhythmicity and age.
Topics: Aging; Animals; Animals, Newborn; Biomarkers; Birds; Circadian Rhythm; Environmental Monitoring; Env | 2007 |
Effect of exogenous melatonin on viability, ingestion capacity, and free-radical scavenging in heterophils from young and old ringdoves (Streptopelia risoria).
Topics: Aging; Animals; Cell Survival; Circadian Rhythm; Columbidae; Female; Free Radical Scavengers; Free R | 2007 |
Tryptophan modulates cell viability, phagocytosis and oxidative metabolism in old ringdoves.
Topics: Aging; Animals; Cell Survival; Circadian Rhythm; Columbidae; Female; Male; Melatonin; Oxidation-Redu | 2007 |
[Prevention and anti-aging in endocrinology].
Topics: Aged; Aging; Dehydroepiandrosterone; Estrogen Replacement Therapy; Female; Hormone Replacement Thera | 2007 |
Melatonin is able to reduce the apoptotic liver changes induced by aging via inhibition of the intrinsic pathway of apoptosis.
Topics: Aging; Animals; Apoptosis; Caspase 3; Caspase 8; Cytochromes c; Glutathione; Liver; Male; Melatonin; | 2007 |
Protective effects of melatonin on renal failure in pinealectomized rats.
Topics: Aging; Animals; Antioxidants; Glutathione; Kidney; Male; Malondialdehyde; Melatonin; Nitric Oxide; P | 2007 |
[Age-related changes of exercise capacity and some biochemical indices of rat muscles under influence of different light conditions and pineal preparations].
Topics: Aging; Animals; Antioxidants; Circadian Rhythm; Light; Melatonin; Muscle, Skeletal; Oligopeptides; P | 2007 |
[Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people].
Topics: Adult; Aged; Aging; Animals; Circadian Rhythm; Female; Humans; Macaca mulatta; Male; Melatonin; Midd | 2007 |
[Thymic factors influence on melatonin-producing pineal function in mice of different age: the possible mechanisms].
Topics: Aging; Animals; Cell Extracts; Epiphyses; Melatonin; Mice; Mice, Inbred CBA; Seasons; Thymic Factor, | 2007 |
Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wake.
Topics: Adolescent; Adult; Aged; Aging; Body Temperature; Circadian Rhythm; Female; Humans; Male; Melatonin; | 2007 |
Melatonin and tryptophan as therapeutic agents against the impairment of the sleep-wake cycle and immunosenescence due to aging in Streptopelia risoria.
Topics: Activity Cycles; Aging; Animals; Columbidae; Leukocytes; Melatonin; Neuroimmunomodulation; Phagocyto | 2007 |
Melatonin restores impaired contractility in aged guinea pig urinary bladder.
Topics: Aging; Amides; Animals; Antioxidants; Calcium; Calcium Signaling; Enzyme Inhibitors; Female; Gene Ex | 2008 |
Molecular mechanisms involved in the hormonal prevention of aging in the rat.
Topics: Aging; Animals; Central Nervous System; Cytochromes c; Cytosol; Estradiol; Estrogens; Female; Growth | 2008 |
Differential effects of melatonin on hippocampal neurodegeneration in different aged accelerated senescence prone mouse-8.
Topics: Aging; Animals; Antioxidants; Disease Models, Animal; Heredodegenerative Disorders, Nervous System; | 2008 |
[Effect of different light regimens on the development of metabolic syndrome of aging rats].
Topics: Aging; Animals; Antioxidants; Blood Glucose; Cholesterol; Eating; Insulin Resistance; Light; Lipopro | 2007 |
[Circannual rhythms of bone marrow cell composition in animals during aging: the role of pineal factors].
Topics: Aging; Animals; Biological Clocks; Bone Marrow Cells; Melatonin; Mice; Mice, Inbred CBA; Oligopeptid | 2007 |
Age-related alterations in Ca2+ signals and mitochondrial membrane potential in exocrine cells are prevented by melatonin.
Topics: Acetylcholine; Aging; Amylases; Animals; Antioxidants; Calcium Signaling; Cells, Cultured; Cholecyst | 2008 |
Aging of the circadian system in zebrafish and the effects of melatonin on sleep and cognitive performance.
Topics: Aging; Animals; Behavior, Animal; Circadian Rhythm; Cognition; Gene Expression Regulation; Melatonin | 2008 |
[Menopause--a key aspect of aging: role of the pineal gland].
Topics: Adolescent; Adult; Aging; Female; Humans; Magnetic Resonance Imaging; Male; Melatonin; Menopause; Mi | 2007 |
Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice.
Topics: Aging; Aging, Premature; alpha-Synuclein; Animals; Antioxidants; Brain; Lewy Bodies; Melatonin; Mice | 2008 |
[Effect of light regimens and melatonin on homeostasis, life span and spontaneous tumorigenesis in male rats].
Topics: Aging; Animals; Antioxidants; Central Nervous System Depressants; Hematologic Neoplasms; Homeostasis | 2008 |
Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice.
Topics: Adenosine Triphosphate; Aging; Aging, Premature; Animals; Disease Models, Animal; Drug Administratio | 2008 |
Effect of melatonin on thyroid hormone secretion rate and feed consumption of female rats.
Topics: Adrenal Glands; Aging; Animals; Appetite; Appetite Regulation; Body Weight; Eating; Female; Melatoni | 1967 |
Effect of melatonin upon thyroid hormone secretion rate and endocrine glands of chicks.
Topics: Adrenal Glands; Aging; Animals; Female; Gonads; Iodine Radioisotopes; Male; Melatonin; Organ Size; P | 1967 |
The pineal gland of the mole (Talpa europaea L.). VII. Activity of hydroxyindole-O-methyltransferase (HIOMT) in the formation of 5-methoxytryptophan, 5-methoxytryptamine, 5-methoxyindole-3-acetic acid, 5-methoxytryptophol and melantonin in the eyes and th
Topics: 5-Methoxytryptamine; Acetylserotonin O-Methyltransferase; Aging; Animals; Eulipotyphla; Eye; Female; | 1981 |
Effects of timed melatonin infusions on reproductive development in the Djungarian hamster (Phodopus sungorus).
Topics: Aging; Animals; Cricetinae; Follicle Stimulating Hormone; Infusions, Parenteral; Isoproterenol; Male | 1984 |
Melatonin in serum and the pineal of spontaneously hypertensive rats.
Topics: Aging; Animals; Hypertension; Male; Melatonin; Pineal Gland; Radioimmunoassay; Rats; Rats, Inbred SH | 1984 |
Daily afternoon administration of melatonin does not irreversibly inhibit sexual maturation in the male rat.
Topics: Aging; Animals; Circadian Rhythm; Drug Administration Schedule; Male; Melatonin; Rats; Rats, Inbred | 1984 |
Negative correlation of age and the levels of pineal melatonin, pineal N-acetylserotonin, and serum melatonin in male rats.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Circadian Rhythm; Male; Melatonin; Pineal Gland; | 1984 |
Patterns of plasma melatonin with ageing and mental condition: stability of nyctohemeral rhythms and differences in seasonal variations.
Topics: Adult; Age Factors; Aged; Aging; Circadian Rhythm; Dementia; Female; Humans; Male; Melatonin; Middle | 1984 |
Ageing, opioid analgesia and the pineal gland.
Topics: Aging; Analgesia; Animals; Benserazide; Circadian Rhythm; Endorphins; Latency Period, Psychological; | 1983 |
Decreased serum and pineal concentrations of melatonin and N-acetylserotonin in aged male hamsters.
Topics: Aging; Animals; Cricetinae; Male; Melatonin; Mesocricetus; Pineal Gland; Radioimmunoassay; Serotonin | 1983 |
Ontogeny of the gonadal response of golden hamsters to short photoperiod, blinding, and melatonin.
Topics: Aging; Animals; Blindness; Cricetinae; Estrus; Female; Gonads; Light; Male; Melatonin; Mesocricetus; | 1982 |
Melatonin rhythms in Pony mares and foals.
Topics: Aging; Animals; Circadian Rhythm; Darkness; Female; Ganglia, Sympathetic; Horses; Light; Melatonin; | 1982 |
Melatonin inhibition of the in vivo pituitary response to luteinizing hormone-releasing hormone in the neonatal rat.
Topics: Aging; Animals; Animals, Newborn; Female; Gonadotropin-Releasing Hormone; Light; Luteinizing Hormone | 1980 |
Localization of melatonin in the digestive tract of the rat. Effect of maturation, diurnal variation, melatonin treatment and pinealectomy.
Topics: Aging; Animals; Circadian Rhythm; Digestive System; Female; Fluorescent Antibody Technique; Male; Me | 1980 |
Melatonin's inhibition of pituitary, adrenal, testicular and accessory gland growth in male golden hamsters: pineal dependence and organ differences with shielding and intracranial surgery.
Topics: Adrenal Glands; Aging; Animals; Cricetinae; Genitalia, Male; Male; Melatonin; Mesocricetus; Organ Si | 1982 |
Plasma and urinary melatonin in male infants during the first 12 months of life.
Topics: Aging; Humans; Infant; Infant, Newborn; Luteinizing Hormone; Male; Melatonin; Metabolic Clearance Ra | 1982 |
Some aspects of the circadian time structure in the elderly.
Topics: Adrenal Glands; Aged; Aging; Circadian Rhythm; Endocrine Glands; Humans; Melatonin; Pituitary Gland, | 1982 |
Melatonin excretion in normal males and females: increase during puberty.
Topics: Adolescent; Adult; Aging; Child; Female; Humans; Kinetics; Male; Melatonin; Menstruation; Middle Age | 1982 |
Circadian rhythmicity and sleep: effects of aging in laboratory animals.
Topics: Aging; Animals; Cats; Circadian Rhythm; Hormones; Locus Coeruleus; Melatonin; Mice; Norepinephrine; | 1982 |
Age-dependent reduction in serum melatonin concentrations in healthy human subjects.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Infant; M | 1982 |
Ontogeny of the pineal melatonin rhythm in golden hamsters.
Topics: Aging; Animals; Animals, Newborn; Cricetinae; Darkness; Light; Male; Melatonin; Mesocricetus; Pineal | 1981 |
Spontaneous and melatonin-induced testicular regression in male golden hamsters: augmented sensitivity of the old male to melatonin inhibition.
Topics: Aging; Animals; Cricetinae; Luteinizing Hormone; Male; Melatonin; Mesocricetus; Organ Size; Prolacti | 1981 |
Evidence that melatonin retention by the neonatal rat is greatly increased as compared to the adult: a novel biochemical mechanism.
Topics: Aging; Animals; Animals, Newborn; Brain; Chromatography, High Pressure Liquid; Female; Liver; Male; | 1981 |
Age-associated reduction in nocturnal pineal melatonin levels in female rats.
Topics: Aging; Animals; Circadian Rhythm; Female; Melatonin; Pineal Gland; Rats; Rats, Inbred Strains | 1981 |
Age-associated changes in pineal serotonin N-acetyltransferase activity and melatonin content in the male gerbil.
Topics: Acetyltransferases; Aging; Animals; Arylamine N-Acetyltransferase; Darkness; Gerbillinae; Light; Mal | 1981 |
Prepubertal sensitivity to melatonin in male hamsters.
Topics: Aging; Animals; Cricetinae; Light; Male; Melatonin; Organ Size; Seasons; Testis | 1980 |
Ontogeny of the pineal melatonin rhythm in the Syrian (Mesocricetus auratus) and Siberian (Phodopus sungorus) hamsters and in the rat.
Topics: Aging; Animals; Circadian Rhythm; Cricetinae; Female; Male; Melatonin; Mesocricetus; Pineal Gland; R | 1980 |
Pineal melatonin rhythm: reduction in aging Syrian hamsters.
Topics: Aging; Animals; Circadian Rhythm; Cricetinae; Melatonin; Mesocricetus; Pineal Gland; Sex Factors | 1980 |
The developmental pattern of in vitro rat liver melatonin degrading activity.
Topics: Aging; Animals; In Vitro Techniques; Liver; Melatonin; Rats | 1981 |
Increased oxidation of pineal serotonin as a possible explanation for reduced melatonin synthesis in the aging Djungarian hamster (Phodopus sungorus).
Topics: Aging; Animals; Circadian Rhythm; Cricetinae; Darkness; Female; Hydroxyindoleacetic Acid; Light; Mel | 1994 |
Seasonal changes in the levels of antidiuretic hormone and melatonin in the elderly.
Topics: Aged; Aged, 80 and over; Aging; Female; Humans; Male; Melatonin; Middle Aged; Radioimmunoassay; Seas | 1995 |
The effect of neonatal pinealectomy on the inhibitory actions of food restriction on vaginal opening and collagen aging in the rat.
Topics: Aging; Analysis of Variance; Animals; Collagen; Female; Food Deprivation; Male; Melatonin; Pineal Gl | 1995 |
Effects of long-term administration of melatonin and a putative antagonist on the ageing rat.
Topics: 5-Methoxytryptamine; Aging; Animals; Body Weight; Hypothalamus; Iodine Radioisotopes; Male; Medulla | 1995 |
Pineal and thyroid functions in newborn seals.
Topics: Aging; Animals; Animals, Newborn; Female; Male; Melatonin; Pineal Gland; Seals, Earless; Thyroid Gla | 1995 |
Neuroendocrine correlates of the aging brain in humans.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Aging; Body Temperature; Brain; Circadi | 1995 |
Preliminary evidence of a synergistic alpha 1- and beta 1-adrenoceptor regulation of rat pineal hydroxyindole-O-methyltransferase.
Topics: Acetylserotonin O-Methyltransferase; Aging; Animals; Body Weight; Circadian Rhythm; Doxazosin; Fencl | 1995 |
Ontogenesis of melatonin receptors in anterior pituitary and pars tuberalis of golden hamsters.
Topics: Aging; Animals; Animals, Newborn; Cricetinae; Female; Male; Melatonin; Mesocricetus; Pituitary Gland | 1994 |
Calcium, calcification, and melatonin biosynthesis in the human pineal gland: a postmortem study into age-related factors.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Calcification, Physiologic; Calcium; Humans; Infant; Me | 1994 |
Effects of aging on photoperiodic responsiveness and specific 2-[125I]-iodomelatonin binding sites in the pars tuberalis and suprachiasmatic nuclei of Siberian hamsters.
Topics: Aging; Animals; Autoradiography; Binding Sites; Cricetinae; Iodine Radioisotopes; Light; Male; Melat | 1994 |
Melatonin treatment mimics pineal graft action in regulating brain cortex adrenoceptors in aging mice.
Topics: Aging; Animals; Cerebral Cortex; Female; Melatonin; Mice; Mice, Inbred BALB C; Pineal Gland; Recepto | 1994 |
Plasma melatonin concentration in neonatal northern elephant seals, Mirounga angustirostris.
Topics: Aging; Animals; Animals, Newborn; Circadian Rhythm; Melatonin; Organ Size; Osmolar Concentration; Pi | 1994 |
[125I]iodomelatonin-binding sites in the bursa of Fabricius of birds: binding characteristics, subcellular distribution, diurnal variations and age studies.
Topics: Aging; Animals; Binding Sites; Birds; Bursa of Fabricius; Chickens; Circadian Rhythm; Columbidae; Co | 1993 |
Modulation of melatonin secretion by acetyl-L-carnitine in adult and old rats.
Topics: Acetylcarnitine; Aging; Animals; Light; Male; Melatonin; Pineal Gland; Rats; Rats, Sprague-Dawley | 1994 |
The effect of 6-months l-deprenyl administration on pineal MAO-A and MAO-B activity and on the content of melatonin and related indoles in aged female Fisher 344N rats.
Topics: Aging; Animals; Female; Indoles; Melatonin; Monoamine Oxidase; Pineal Gland; Rats; Rats, Inbred F344 | 1994 |
Melatonin restores immunodepression in aged and cyclophosphamide-treated mice.
Topics: Adjuvants, Immunologic; Aging; Animals; Antibody Formation; Cell Line; Cells, Cultured; Cyclophospha | 1994 |
The decrease of pineal melatonin production with age. Causes and consequences.
Topics: Aging; Animals; Antimony; Calcium; Cell Count; Cell Membrane Permeability; Electron Probe Microanaly | 1994 |
The immuno-reconstituting effect of melatonin or pineal grafting and its relation to zinc pool in aging mice.
Topics: Aging; Animals; Antigens, CD; Cell Division; Immunity; Immunophenotyping; Male; Melatonin; Mice; Pin | 1994 |
Pineal control of aging: effect of melatonin and pineal grafting on aging mice.
Topics: Aging; Animals; Biological Clocks; Circadian Rhythm; Female; Male; Melatonin; Mice; Mice, Inbred BAL | 1994 |
Introduction. Melatonin and the light-dark zeitgeber in vertebrates, invertebrates and unicellular organisms.
Topics: Aging; Animals; Biological Clocks; Biological Evolution; Circadian Rhythm; Darkness; Light; Melatoni | 1993 |
The effects of aging on diurnal water intake and melatonin binding in the suprachiasmatic nucleus.
Topics: Aging; Animals; Autoradiography; Circadian Rhythm; Drinking; Male; Melatonin; Rats; Suprachiasmatic | 1993 |
Developmental appearance and age related changes in specific 2-[125I]iodomelatonin binding sites in the suprachiasmatic nuclei of female Syrian hamsters.
Topics: Aging; Animals; Autoradiography; Circadian Rhythm; Cricetinae; Female; Iodine Radioisotopes; Melaton | 1993 |
Age-related changes in melatonin modulation of sympathetic neurotransmission.
Topics: Acetylcholine; Aging; Animals; Circadian Rhythm; Darkness; Drug Interactions; Light; Male; Melatonin | 1993 |
Circadian secretion of melatonin and thyrotropin in hospitalized aged patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Circadian Rhythm; Female; Hospitalization; Humans; Male; Mela | 1993 |
The acute effects of starvation on 6-sulphatoxy-melatonin output in subgroups of patients with anorexia nervosa.
Topics: Adolescent; Adult; Aging; Anorexia Nervosa; Circadian Rhythm; Depression; Female; Humans; Melatonin; | 1993 |
Patterns of melatonin secretion during sexual maturation in female ferrets.
Topics: Aging; Animals; Circadian Rhythm; Female; Ferrets; Melatonin; Photoperiod; Pineal Gland; Sexual Matu | 1995 |
Lithium chloride enhances survival of NZB/W lupus mice: influence of melatonin and timing of treatment.
Topics: Adjuvants, Immunologic; Aging; Animals; Antibodies, Antinuclear; Disease Progression; DNA, Single-St | 1995 |
Age-related changes of neuronal responsiveness to melatonin in the striatum of sham-operated and pinealectomized rats.
Topics: Aging; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Electrophysiology; Male; Melatoni | 1995 |
Pharmacokinetics of melatonin in human sexual maturation.
Topics: Adolescent; Adult; Aging; Body Weight; Child; Circadian Rhythm; Female; Humans; Male; Melatonin; Pil | 1996 |
Melatonin.
Topics: Aging; Circadian Rhythm; Humans; Melatonin; Sleep; Sleep Wake Disorders | 1996 |
The modulatory effect of melatonin on the dopamine-glutamate interaction in the anterior hypothalamus during ageing.
Topics: Aging; Amphetamine; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Dopamine; Dopamine | 1995 |
The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes.
Topics: Aging; Animals; Antioxidants; Apoptosis; Cells, Cultured; DNA; Melatonin; Microscopy, Electron, Scan | 1995 |
Decrease in melatonin precedes follicle-stimulating hormone increase during perimenopause.
Topics: Adult; Aged; Aging; Circadian Rhythm; Female; Follicle Stimulating Hormone; Humans; Melatonin; Middl | 1996 |
Premature ageing: the link between psychosocial risk factors and disease.
Topics: Aging; Chronic Disease; Coronary Disease; Health Status; Humans; Life Style; Melatonin; Models, Theo | 1996 |
Effect of melatonin and pineal grafting on thymocyte apoptosis in aging mice.
Topics: Aging; Animals; Apoptosis; Cells, Cultured; Male; Melatonin; Mice; Mice, Inbred BALB C; Pineal Gland | 1996 |
Enhanced reproductive responses to melatonin in juvenile Siberian hamsters.
Topics: Aging; Animals; Animals, Newborn; Cricetinae; Female; Male; Melatonin; Motor Activity; Organ Size; P | 1996 |
5-Methoxytryptophol and melatonin in children: differences due to age and sex.
Topics: Adolescent; Aging; Biomarkers; Child; Child Development; Chronobiology Phenomena; Estradiol; Female; | 1996 |
Effects of melatonin, testosterone and the two hormones administered in parallel on epididymis of the rat estrogenized with stilbestrol in the first day of life.
Topics: Aging; Animals; Animals, Newborn; Diethylstilbestrol; Drug Interactions; Epididymis; Epithelial Cell | 1996 |
Chrono-neuroendocrine markers of the aging brain.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Body Temperature; Br | 1996 |
6-Hydroxymelatonin sulfate excretion in human puberty.
Topics: Adolescent; Adult; Aging; Body Constitution; Child; Child, Preschool; Creatinine; Cross-Sectional St | 1996 |
Promotion of interleukin-2 activity as a strategy for 'rejuvenating' geriatric immune function.
Topics: Aging; Animals; Antioxidants; Carotenoids; Chromium; Clonal Anergy; Dehydroepiandrosterone; Diet; HI | 1997 |
Super hype for super hormones.
Topics: Aged; Aging; Dehydroepiandrosterone; Food, Organic; Human Growth Hormone; Humans; Melatonin; Testost | 1997 |
[Effect of melatonin and epithalamin on life span and lipid peroxidation in Drosophila melanogaster].
Topics: Aging; Animals; Drosophila melanogaster; Life Expectancy; Lipid Peroxidation; Melatonin; Peptides | 1997 |
[Juvenile hormones, reality or myth?].
Topics: Aged; Aging; Animals; Dehydroepiandrosterone; Female; Humans; Life Expectancy; Male; Melatonin; Mice | 1997 |
Failure of melatonin implants to alter onset of puberty in gilts.
Topics: Aging; Animals; Drug Implants; Estrus; Female; Melatonin; Progesterone; Radioimmunoassay; Sexual Mat | 1997 |
Malondialdehyde and glutathione in rat gastric mucosa and effects of exogenous melatonin.
Topics: Aging; Animals; Free Radicals; Gastric Mucosa; Glutathione; Malondialdehyde; Melatonin; Rats; Rats, | 1997 |
In vitro effects of melatonin on mitogen-induced lymphocyte proliferation and cytokine expression in young and old rats.
Topics: Aging; Animals; Cells, Cultured; Cytokines; Interferon-gamma; Interleukin-2; Lymphocyte Activation; | 1997 |
Changes in endocrine circadian rhythms as markers of physiological and pathological brain aging.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Aging; Brain; Circadian Rhythm; Dementi | 1997 |
[Melatonin biosynthesis in the epiphysis during early postnatal ontogenesis in healthy persons and in patients with hereditary retinal degeneration].
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Melatonin; Norepinephrine; Pineal Gland; Rats; | 1997 |
Long-term melatonin supplementation does not recover the impairment of natural killer cell activity and lymphocyte proliferation in aging mice.
Topics: Adjuvants, Immunologic; Aging; Animals; Cell Count; Interleukin-2; Killer Cells, Natural; Lymphocyte | 1997 |
Effects of aging and melatonin administration on gonadotropin-releasing hormones (GnRH) gene expression in the male and female rat.
Topics: Aging; Animals; Female; Gene Expression; Gonadotropin-Releasing Hormone; In Situ Hybridization; Male | 1997 |
Metabolic costs of mounting an antigen-stimulated immune response in adult and aged C57BL/6J mice.
Topics: Aging; Animals; Antibody Formation; Antigens; Body Temperature; Body Temperature Regulation; Calorim | 1997 |
[Melatonin: use and abuse].
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Antioxidants; Child; Circadian Rhythm; Contraceptives, | 1997 |
Differential inhibitory effects of melatonin analogs and three naphthalenic ligands on 2-[125I]iodomelatonin binding to chicken tissues.
Topics: Aging; Animals; Binding, Competitive; Brain; Chickens; Female; Guanosine 5'-O-(3-Thiotriphosphate); | 1997 |
Responsiveness to melatonin and its receptor expression in the aging circadian clock of mice.
Topics: Aging; Animals; Circadian Rhythm; Darkness; Gene Expression Regulation, Developmental; Light; Male; | 1997 |
Aging and endocrinology.
Topics: Aging; Animals; Clinical Trials as Topic; Dehydroepiandrosterone; Drug Synergism; Female; Humans; Me | 1998 |
Sulphatoxymelatonin excretion in older people: relationship to plasma melatonin and renal function.
Topics: Aged; Aged, 80 and over; Aging; Creatinine; Female; Humans; Kidney; Male; Melatonin; Middle Aged; Pi | 1998 |
A significant correlation between melatonin deficiency and endometrial cancer.
Topics: Aging; Austria; Biomarkers, Tumor; Cohort Studies; Endometrial Neoplasms; Female; Humans; Incidence; | 1998 |
Melatonin: marvel or marker?
Topics: Adult; Aged; Aged, 80 and over; Aging; Case-Control Studies; Circadian Rhythm; Depression; Female; H | 1998 |
Effect of melatonin on 24-hour rhythms of ornithine decarboxylase activity and norepinephrine and acetylcholine synthesis in submaxillary lymph nodes and spleen of young and aged rats.
Topics: Acetylcholine; Aging; Animals; Arthritis, Experimental; Circadian Rhythm; Lymph Nodes; Male; Maxilla | 1998 |
Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on the survival.
Topics: Aging; Animals; Antioxidants; Body Weight; Cells, Cultured; Circadian Rhythm; Corticosterone; Male; | 1998 |
Melatonin: immune modulation of spleen cells in young, middle-aged and senescent mice.
Topics: Adjuvants, Immunologic; Aging; Animals; Antibody Formation; Concanavalin A; Interleukin-2; Lipopolys | 1998 |
Changes with age in daytime and nighttime contents of melatonin, indoleamines, and catecholamines in the pineal gland: a comparative study in rat and Syrian hamster.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Aging; Animals; Catecholamines; Circadian Rhyth | 1998 |
Antioxidants and aging: is melatonin a possible, practical new hope?
Topics: Aging; Animals; Antioxidants; Humans; Melatonin | 1998 |
Day and night dysfunction in intraretinal melatonin and related indoleamines metabolism, correlated with the development of glaucoma-like disorder in an avian model.
Topics: Acetylserotonin O-Methyltransferase; Aging; Amines; Animals; Circadian Rhythm; Coturnix; Glaucoma; H | 1998 |
Melatonin for the masses. Antiaging entrepreneurs peddle therapies that promise to cheat the clock.
Topics: Aged; Aging; Animals; Biological Clocks; Complementary Therapies; Entrepreneurship; Hospital Restruc | 1998 |
Diurnal rhythms in norepinephrine and acetylcholine synthesis of sympathetic ganglia, heart and adrenals of aging rats: effect of melatonin.
Topics: Acetylcholine; Adrenal Glands; Aging; Animals; Choline; Circadian Rhythm; Ganglia, Sympathetic; Hear | 1998 |
Daily and seasonal variations in the concentration of melatonin in the human pineal gland.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Cadaver; Circadian Rhythm; Humans; Male; Melatoni | 1998 |
Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Apolipoproteins E; Circadian Rhythm; Female; Geno | 1999 |
Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels.
Topics: Adipose Tissue; Aging; Animals; Drug Administration Schedule; Epididymis; Insulin; Leptin; Male; Mel | 1999 |
Differential effects of pharmacological doses of melatonin on malondialdehyde and glutathione levels in young and old rats.
Topics: Aging; Animals; Antioxidants; Brain; Glutathione; Lipid Peroxidation; Liver; Lung; Male; Malondialde | 1999 |
Anti-aging hormones.
Topics: Aging; Dehydroepiandrosterone; Estrogens; Human Growth Hormone; Humans; Melatonin; Testosterone | 1999 |
[Melatonin as geroprotector: experiments with Drosophila melanogaster].
Topics: Aging; Animals; Drosophila; Female; Longevity; Male; Melatonin | 1999 |
Geroprotector effectiveness of melatonin: investigation of lifespan of Drosophila melanogaster.
Topics: Aging; Animals; Antioxidants; Culture Media; Drosophila melanogaster; Female; Longevity; Male; Melat | 1999 |
Normative melatonin excretion: a multinational study.
Topics: Adolescent; Adult; Aging; Body Height; Body Weight; Climate; Female; Humans; Logistic Models; Male; | 1999 |
Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Body Temperature; Circadian Rhythm; Humans; Melat | 1999 |
Transient entrainment of a circadian pacemaker during development by dopaminergic activation in Syrian hamsters.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Circadian Rhythm; Cricet | 1999 |
Mechanisms underlying the effects of estrogen on nocturnal melatonin synthesis in peripubertal female rats: relation to norepinephrine and adenylate cyclase.
Topics: Adenylyl Cyclases; Aging; Animals; Circadian Rhythm; Cyclic AMP; Estradiol; Female; Light; Melatonin | 1999 |
Age-related differences in serum melatonin and pineal NAT activity and in the response of rat pineal to a 50-Hz magnetic field.
Topics: Acetylserotonin O-Methyltransferase; Aging; Animals; Arylamine N-Acetyltransferase; Circadian Rhythm | 1999 |
Stability, precision, and near-24-hour period of the human circadian pacemaker.
Topics: Adult; Aged; Aging; Biological Clocks; Body Temperature; Circadian Rhythm; Darkness; Female; Humans; | 1999 |
Modification of physical movement in old C57BL/6 mice by DHEA and melatonin supplementation.
Topics: Age Factors; Aging; Animals; Behavior, Animal; Dehydroepiandrosterone; Female; Locomotion; Melatonin | 1999 |
A clock for the ages.
Topics: Aging; Biological Clocks; Body Temperature; Circadian Rhythm; Darkness; Humans; Hydrocortisone; Ligh | 1999 |
Physiological levels of melatonin contribute to the antioxidant capacity of human serum.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antioxidants; Child; Child, Preschool; Circadian | 1999 |
Inhibitory effects of melatonin on free intracellular calcium in mouse brain cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1999 |
Changes in nocturnal pineal melatonin synthesis during the perimenopausal period: relation to estrogen levels in female rats.
Topics: Acetylserotonin O-Methyltransferase; Aging; Animals; Arylamine N-Acetyltransferase; Circadian Rhythm | 1999 |
The molecular clock, the biological clock and general physiology and biophysics.
Topics: Aging; Animals; Biological Clocks; Biological Evolution; Biophysics; Career Mobility; DNA, Mitochond | 1999 |
Melatonin protects against age-related DNA damage in the brains of female senescence-accelerated mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aging; Animals; Brain; Circadian Rhythm; Deoxyguanosine; DNA Damage; Fe | 1999 |
Do plasma melatonin concentrations decline with age?
Topics: Adult; Aged; Aged, 80 and over; Aging; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep Wake | 1999 |
Augmentation of indices of oxidative damage in life-long melatonin-deficient rats.
Topics: Aging; Animals; Antioxidants; DNA Damage; Free Radical Scavengers; Lipid Peroxidation; Male; Melaton | 1999 |
The effects of dietary antioxidants on psychomotor performance in aged mice.
Topics: Aging; Animals; Antioxidants; Dietary Supplements; Glutathione; Male; Melatonin; Mice; Mice, Inbred | 1999 |
In vitro pituitary responsiveness to LHRH in young and old female rats. Influence of melatonin.
Topics: Aging; Animals; Antioxidants; Female; Fertility Agents, Female; Follicle Stimulating Hormone; Gonado | 1999 |
Effect of exogenous melatonin on neuroendocrine-reproductive function of middle-aged female rats.
Topics: Aging; Analysis of Variance; Animals; Estradiol; Estrus; Female; Follicle Stimulating Hormone; Gonad | 1999 |
Changes in nocturnal melatonin secretion in perimenopausal women: correlation with endogenous estrogen concentrations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Circadian Rhythm; Estradiol; Estrogen Replacement | 2000 |
Melatonin and aging: relevance for clinical approach?
Topics: Action Potentials; Aging; Circadian Rhythm; Humans; Male; Melatonin; Neocortex; Receptors, Cell Surf | 1999 |
Ageing and melatonin influence on in vitro gonadotropins and prolactin secretion from pituitary and median eminence.
Topics: Aging; Animals; Female; Gonadotropins; In Vitro Techniques; Median Eminence; Melatonin; Pituitary Gl | 2000 |
Melatonin normalizes the re-entrainment of senescence accelerated mice (SAM) to a new light-dark cycle.
Topics: Aging; Animals; Circadian Rhythm; Gene Expression Regulation; Male; Melatonin; Mice; Mice, Mutant St | 1999 |
Developmental expression of both melatonin receptor mt1 mRNA and melatonin binding sites in Syrian hamster suprachiasmatic nuclei.
Topics: Aging; Amino Acid Sequence; Animals; Animals, Newborn; Binding Sites; Cricetinae; Female; Gene Expre | 1999 |
Melatonin influence upon ovary during ageing. A morphometric study.
Topics: Aging; Animals; Female; Melatonin; Oocytes; Ovary; Rats | 1999 |
Melatonin effect during aging on reproductive hormones of female rats through the estrous cycle.
Topics: Aging; Animals; Estradiol; Estrus; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Melato | 1999 |
Long-term supplementation with melatonin delays reproductive senescence in rats, without an effect on number of primordial follicles.
Topics: Aging; Animals; Drug Administration Schedule; Female; Male; Melatonin; Ovarian Follicle; Ovarian Neo | 2000 |
Hormonal deficiency in elderly males.
Topics: Aged; Aging; Androgens; Hormone Replacement Therapy; Humans; Male; Melatonin | 2000 |
Age-related decreases in melatonin secretion--clinical consequences.
Topics: Adolescent; Aging; Child; Circadian Rhythm; Female; Humans; Male; Melatonin; Pineal Gland | 2000 |
Is carbonyl detoxification an important anti-aging process during sleep?
Topics: Aging; Circadian Rhythm; Humans; Ketones; Melatonin; Sleep; Thiobarbituric Acid Reactive Substances | 2000 |
Effects of ageing and exogenous melatonin on pituitary responsiveness to GnRH in rats.
Topics: Aging; Animals; Estradiol; Estrus; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Horm | 2000 |
Sleep and circadian phase characteristics of adolescent and young adult males in a naturalistic summertime condition.
Topics: Adolescent; Adult; Aging; Circadian Rhythm; Humans; Male; Melatonin; Polysomnography; Seasons; Sleep | 2000 |
[The effect of melatonin on the indices of biological age, on longevity and on the development of spontaneous tumors in mice].
Topics: Aging; Animals; Body Temperature; Estrus; Female; Free Radical Scavengers; Free Radicals; Longevity; | 2000 |
Age-related morphometric changes in the pineal gland. A comparative study between C57BL/6J and CBA mice.
Topics: Aging; Animals; Cell Nucleus; Image Processing, Computer-Assisted; Male; Melatonin; Mice; Mice, Inbr | 2000 |
Cause of idiopathic scoliosis.
Topics: Adolescent; Adult; Aging; Antioxidants; Biomarkers; Child; Circadian Rhythm; Disease Progression; Hu | 2000 |
Prenatal melatonin exposure affects luteinizing hormone and hypothalamic and striatal neuropeptide Y in the male rat offspring.
Topics: Aging; Animals; Corpus Striatum; Female; Gene Expression Regulation, Developmental; Hypothalamus; Lu | 2000 |
A melatonin agonist facilitates circadian resynchronization in old hamsters after abrupt shifts in the light-dark cycle.
Topics: Acetamides; Aging; Animals; Biological Clocks; Circadian Rhythm; Cricetinae; Darkness; Light; Melato | 2000 |
Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Coronary Disease; Female; Humans; Male; Melatonin; Middle Age | 2000 |
Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study.
Topics: Aging; Animals; Behavior, Animal; Blood Glucose; Body Composition; Body Weight; Bone Density; Dehydr | 2000 |
Circadian and sleep disturbances in the elderly.
Topics: Aged; Aging; Circadian Rhythm; Humans; Melatonin; Photoperiod; Sleep; Sleep Wake Disorders; Suprachi | 2000 |
Pineal and pituitary-adrenocortical function in physiological aging and in senile dementia.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Circadian Rhy | 2000 |
Pituitary responsiveness to diurnal and nocturnal GnRH pulses in melatonin-treated ewe lambs.
Topics: Aging; Animals; Circadian Rhythm; Female; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Melat | 2000 |
Effects of aging on the intrinsic circadian period of totally blind humans.
Topics: Adult; Aging; Blindness; Circadian Rhythm; Humans; Male; Melatonin; Middle Aged; Regression Analysis | 2001 |
Diminished melatonin secretion in the elderly caused by insufficient environmental illumination.
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Humans; Lighting; Male; Melatonin; Periodicity; Refer | 2001 |
Antagonistic effects of melatonin on glutamate release and neurotoxicity in cerebral cortex.
Topics: Aging; Animals; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Melatonin; Mice; Neurons; Neuroprot | 1999 |
Melatonin synthesis in the rat harderian gland: age- and time-related effects.
Topics: Acetylserotonin O-Methyltransferase; Aging; Analysis of Variance; Animals; Arylamine N-Acetyltransfe | 2001 |
Melatonin or a melatonin agonist corrects age-related changes in circadian response to environmental stimulus.
Topics: Acetamides; Aging; Animals; Circadian Rhythm; Cricetinae; Darkness; Light; Male; Melatonin; Mesocric | 2001 |
Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks.
Topics: Aging; Alzheimer Disease; Amnesia; Animals; Antioxidants; Avoidance Learning; Data Interpretation, S | 2001 |
Correlation between the age of pinealectomy and the development of scoliosis in chickens.
Topics: Aging; Animals; Animals, Newborn; Chickens; Female; Melatonin; Neurosurgical Procedures; Osmolar Con | 2001 |
A comparative study of the effects of cholesterol, beta-sitosterol, beta-sitosterol glucoside, dehydroepiandrosterone sulphate and melatonin on in vitro lipid peroxidation.
Topics: Aging; Androsterone; Antioxidants; Blood Platelets; Cholesterol; Free Radical Scavengers; Humans; Hy | 2000 |
Melatonin in older people with age-related sleep maintenance problems: a comparison with age matched normal sleepers.
Topics: Aged; Aged, 80 and over; Aging; Case-Control Studies; Female; Humans; Male; Melatonin; Sleep Wake Di | 2001 |
Aging, reproduction, and the melatonin rhythm in the Siberian hamster.
Topics: Aging; Animals; Circadian Rhythm; Cricetinae; Female; Fertility; Gonadotropin-Releasing Hormone; Mal | 2001 |
The effects of melatonin on humoral immune responses of young and aged rats.
Topics: Aging; Animals; Antibody Formation; Erythrocytes; Immunization; Immunoglobulin G; Immunoglobulin M; | 2001 |
Effects of photoperiod and melatonin on the development of growth hormone cells and the pituitary-adrenal axis in the Djungarian hamster, Phodopus sungorus.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aging; Animals; Body Weight; Cricetinae; Growth Hormone | 2001 |
Dietary caloric restriction prevents the age-related decline in plasma melatonin levels of rhesus monkeys.
Topics: Aging; Animals; Circadian Rhythm; Diet; Energy Intake; Female; Macaca mulatta; Male; Melatonin | 2001 |
Melatonin increases both life span and tumor incidence in female CBA mice.
Topics: Aging; Animals; Body Weight; Brain; Estrus; Female; Free Radicals; Incidence; Liver; Locomotion; Lon | 2001 |
Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aging; Alzheimer Disease; Autopsy; Brain; Catec | 2001 |
Antioxidant and antiaging activity of N-acetylserotonin and melatonin in the in vivo models.
Topics: Aging; Aldehydes; Animals; Antioxidants; Body Weight; Brain; Female; Glutathione Peroxidase; Kidney; | 2001 |
Actigraphic sleep-wake patterns and urinary 6-sulfatoxymelatonin excretion in patients with Alzheimer's disease.
Topics: Adult; Aged; Aging; Alzheimer Disease; Circadian Rhythm; Dementia; Female; Humans; Light; Male; Mela | 2001 |
Aging-dependent changes in the effect of daily melatonin supplementation on rat metabolic and behavioral responses.
Topics: Adipose Tissue; Aging; Animals; Behavior, Animal; Insulin; Leptin; Male; Melatonin; Pineal Gland; Ra | 2001 |
Synthetic tetrapeptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys.
Topics: Aging; Animals; Circadian Rhythm; Endocrine System Diseases; Female; Macaca mulatta; Melatonin; Nerv | 2001 |
Regulatory effect of Epithalon on production of melatonin and cortisol in old monkeys.
Topics: Aging; Animals; Antioxidants; Female; Hydrocortisone; Macaca mulatta; Melatonin; Oligopeptides | 2001 |
Circadian abnormalities in older adults.
Topics: Adult; Aged; Aging; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Polysomnograp | 2001 |
Gut neuroendocrine cells: relationship to the proliferative activity and apoptosis of mucous epitheliocytes in aging.
Topics: Aging; Animals; Apoptosis; Cell Count; Cell Division; Duodenum; Epithelial Cells; Gastric Mucosa; Hi | 2001 |
Artificially accelerated aging by shortened photoperiod alters early gene expression (Fos) in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, Microcebus murinus.
Topics: Aging; Animals; Body Weight; Cheirogaleidae; Circadian Rhythm; Gene Expression Regulation; Immunohis | 2001 |
Pinealectomy-associated decrease in ribosomal gene activity in rats.
Topics: Aging; Animals; Male; Melatonin; Nucleolus Organizer Region; Pineal Gland; Rats; Rats, Wistar; Ribos | 2001 |
Dietary modulation of age-related changes in cerebral pro-oxidant status.
Topics: Aging; alpha-Tocopherol; Analysis of Variance; Animals; Antioxidants; Cerebral Cortex; Diet; Glutath | 2002 |
Chronobiological aspects of melatonin-produced antioxidant effects in senescent rats.
Topics: Aging; Animals; Antioxidants; Cellular Senescence; Dose-Response Relationship, Drug; Hydrogen Peroxi | 2001 |
Ontogeny of circadian expression of serotonin N-acetyltransferase mRNA in the rat retina.
Topics: Aging; Animals; Animals, Newborn; Arylamine N-Acetyltransferase; Biological Clocks; Circadian Rhythm | 2002 |
Supplementary dim light differentially influences sexual maturity, oviposition time, and melatonin rhythms in pullets.
Topics: Aging; Animals; Antioxidants; Chickens; Circadian Rhythm; Female; Melatonin; Oviposition; Photoperio | 2001 |
[Effect of melatonin on the spatial and temporal changes of [Ca2+]i in single living cells of cortical neurons by laser scanning confocal microscopy].
Topics: Aging; Animals; Calcium; Cerebral Cortex; Female; Melatonin; Microscopy, Confocal; Neurons; Rats; Ra | 2000 |
Peak of circadian melatonin rhythm occurs later within the sleep of older subjects.
Topics: Adult; Aged; Aging; Circadian Rhythm; Female; Humans; Male; Melatonin; Sleep | 2002 |
Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse.
Topics: Acetylcholine; Aging; Animals; Cell Differentiation; Central Nervous System; Dopamine; Epinephrine; | 2002 |
Melatonin in rat milk and the likelihood of its role in postnatal maternal entrainment of rhythms.
Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Female; Likelihood Functions; Melatonin; Mil | 2002 |
Melatonin fails to modulate immune parameters influenced by calorie restriction in aging Fischer 344 rats.
Topics: Adjuvants, Immunologic; Aging; Animals; Diet; Energy Intake; Immunity; Melatonin; Rats; Rats, Inbred | 2002 |
Nighttime changes in norepinephrine and melatonin content and serotonin turnover in pineal glands of young and old rats injected with Freund's adjuvant.
Topics: Aging; Animals; Circadian Rhythm; Freund's Adjuvant; Hydroxyindoleacetic Acid; Injections, Subcutane | 2002 |
Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin.
Topics: Aging; Animals; Antioxidants; Drosophila melanogaster; Drug Resistance; Free Radical Scavengers; Fre | 2002 |
[Urinary excretion of 6-sulphatoxymelatonin in normal subjects: statistical approach to the influence of age and sex].
Topics: Adolescent; Adult; Aged; Aging; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Refe | 2002 |
Feeding melatonin enhances the phase shifting response to triazolam in both young and old golden hamsters.
Topics: Administration, Oral; Aging; Animals; Circadian Rhythm; Cricetinae; Drug Synergism; In Vitro Techniq | 2002 |
[Melatonin/circadian rhythm. Is there a feedback between epiphysis and hypophysis?].
Topics: Adult; Aging; Biological Clocks; Circadian Rhythm; Feedback; Female; Human Growth Hormone; Humans; H | 2002 |
Neuronal expression of arylalkylamine N-acetyltransferase (AANAT) mRNA in the rat brain.
Topics: Aging; Animals; Arylamine N-Acetyltransferase; Brain; Cerebellum; Circadian Rhythm; Gene Expression; | 2002 |
Differential regulation of luteinizing hormone and follicle-stimulating hormone in male siberian hamsters by exposure to females and photoperiod.
Topics: Aging; Animals; Body Weight; Cricetinae; Female; Follicle Stimulating Hormone; Gonadotropin-Releasin | 2002 |
Melatonin protects hepatic mitochondrial respiratory chain activity in senescence-accelerated mice.
Topics: Administration, Oral; Aging; Animals; Antioxidants; Cell Respiration; Female; Glutathione Peroxidase | 2002 |
Age differences in neurokinin A and substance P from the hypothalamus, pituitary, pineal gland, and striatum of the rat. Effect of exogenous melatonin.
Topics: Aging; Animals; Female; Hypothalamus; Injections, Subcutaneous; Melatonin; Neostriatum; Neurokinin A | 2002 |
[Aging of the pineal gland].
Topics: Aging; Animals; Antioxidants; Female; Melatonin; Monoamine Oxidase Inhibitors; Oligopeptides; Pineal | 2002 |
Evidence for an endocrine function of the human pineal gland. Chairman's introduction.
Topics: Aging; Humans; Melatonin; Pineal Gland | 1978 |
Melatonin in the retina and the Harderian gland. Ontogeny, diurnal variations and melatonin treatment.
Topics: Aging; Animals; Circadian Rhythm; Darkness; Female; Fluorescent Antibody Technique; Harderian Gland; | 1978 |
Developmental loss of the acute inhibitory effect of melatonin on the in vitro pituitary luteinizing hormone and follicle-stimulating hormone responses to luteinizing hormone-releasing hormone.
Topics: Aging; Animals; Castration; Cells, Cultured; Female; Follicle Stimulating Hormone; Gonadotropin-Rele | 1979 |
Effect of melatonin on photic-independent and photic-dependent testicular growth in juvenile and adult male golden hamsters.
Topics: Aging; Animals; Circadian Rhythm; Cricetinae; Light; Male; Melatonin; Mesocricetus; Organ Size; Semi | 1979 |
Melatonin in human cerebrospinal fluid in daytime; its origin and variation with age.
Topics: Adolescent; Adult; Aged; Aging; Child; Female; Humans; Hydroxyindoleacetic Acid; Male; Melatonin; Mi | 1979 |
Effects of sham-pinealectomy, performed under white and red light, on the melatonin content of rat pineal glands.
Topics: Aging; Animals; Animals, Newborn; Light; Male; Melatonin; Pineal Gland; Rats | 1979 |
Induced PKU in rats: effects of age and melatonin treatment.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Female; Humans; Learning; Melatonin | 1977 |
Pineal serotonin N-acetyltransferase activity and melatonin concentrations in prepubertal and adult Syrian hamsters exposed to short daily photoperiods.
Topics: Acclimatization; Acetyltransferases; Aging; Animals; Cricetinae; Darkness; Light; Male; Melatonin; M | 1978 |
Pineal muscarinic phosphoinositide responses: age-associated sensitization, agonist-induced desensitization and increase in melatonin release from cultured pineal glands.
Topics: Aging; Animals; Carbachol; Culture Techniques; Inositol; Kinetics; Male; Melatonin; Phosphatidylinos | 1992 |
Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells.
Topics: Aging; Animals; Animals, Newborn; Calcium; Cell Membrane; Female; Fluorescent Dyes; Gonadotropin-Rel | 1992 |
The ontogeny of 2-[125I]iodomelatonin binding sites in chicken brain.
Topics: Aging; Animals; Binding Sites; Binding, Competitive; Brain; Chick Embryo; Chickens; Iodine Radioisot | 1992 |
The involvement of pineal gland and melatonin in immunity and aging: II. Thyrotropin-releasing hormone and melatonin forestall involution and promote reconstitution of the thymus in anterior hypothalamic area (AHA)-lesioned mice.
Topics: Aging; Animals; Female; Hypothalamus; Lymphocytes; Melatonin; Mice; Naltrexone; Pineal Gland; Stereo | 1992 |
Effects of melatonin treatment on the attainment of puberty in heifers.
Topics: Aging; Animals; Body Weight; Cattle; Circadian Rhythm; Drug Implants; Female; Melatonin; Random Allo | 1992 |
Evidence for direct vasoconstrictor activity of melatonin in "pressurized" segments of isolated caudal artery from juvenile rats.
Topics: Aging; Animals; Antihypertensive Agents; Arteries; Brimonidine Tartrate; Female; In Vitro Techniques | 1992 |
Melatonin treatment delays reproductive aging of female rat via the opiatergic system.
Topics: Aging; Animals; Anovulation; Endorphins; Estrus; Female; Luteinizing Hormone; Melatonin; Rats; Rats, | 1992 |
Effect of pineal peptide preparation (epithalamin) on life span and pineal and serum melatonin level in old rats.
Topics: Aging; Animals; Estrus; Female; Longevity; Male; Melatonin; Neoplasms; Peptides; Pineal Gland; Rats; | 1992 |
Relation of age to circadian adjustment to night work.
Topics: Adult; Aging; Body Temperature; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Sali | 1992 |
Plasma melatonin rhythm in normal puberty: interactions of age and pubertal stages.
Topics: Adolescent; Aging; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Male; Melatonin; Puber | 1992 |
[Age-related characteristics of the effects of epithalamin on serotonin metabolism in the pineal gland of rats].
Topics: Aging; Animals; Male; Melatonin; Peptides; Pineal Gland; Rats; Rats, Inbred Strains; Serotonin | 1992 |
Development of melatonin production in infants and the impact of prematurity.
Topics: Aging; Humans; Infant; Infant, Newborn; Infant, Premature; Melatonin; Reference Values | 1992 |
Food restriction retards aging of the pineal gland.
Topics: Aging; Animals; Arylamine N-Acetyltransferase; Diet, Reducing; Energy Intake; Hydroxyindoleacetic Ac | 1991 |
The response of the pineal melatonin biosynthesis to the selective MAO-A inhibitor, clorgyline, in young and middle-aged rats.
Topics: Aging; Animals; Clorgyline; Hydroxyindoleacetic Acid; Light; Male; Melatonin; Pineal Gland; Rats; Ra | 1991 |
Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells.
Topics: Aging; Animals; Animals, Newborn; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Female | 1992 |
Effect of ageing on melatonin synthesis induced by 5-hydroxytryptophan and constant light in rats.
Topics: 5-Hydroxytryptophan; Aging; Animals; Light; Male; Melatonin; Pineal Gland; Rats; Rats, Inbred Strain | 1991 |
Melatonin levels in hospitalized elderly patients: a comparison with community based volunteers.
Topics: Aged; Aging; Circadian Rhythm; Hospitalization; Humans; Lighting; Long-Term Care; Melatonin; New Zea | 1991 |
Plasma melatonin rhythm in disorders of puberty: interactions of age and pubertal stages.
Topics: Adolescent; Aging; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Hypopituitarism; Male; | 1991 |
Pituitary-adrenocortical and pineal activities in the aged rat. Effects of long-term treatment with acetyl-L-carnitine.
Topics: Acetylcarnitine; Adrenal Cortex; Aging; Animals; Male; Melatonin; Pineal Gland; Pituitary-Adrenal Sy | 1991 |
The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice.
Topics: Aging; Animals; Female; Life Expectancy; Melatonin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; P | 1991 |
Melatonin: a chronobiotic with anti-aging properties?
Topics: Aging; Animals; Circadian Rhythm; Cricetinae; Diptera; Feedback; Female; Humans; Immune System; Male | 1991 |
Serum melatonin in central precocious puberty is lower than in age-matched prepubertal children.
Topics: Aging; Child; Child, Preschool; Circadian Rhythm; Female; Follicle Stimulating Hormone; Gonadotropin | 1991 |
[Effects of hypothermal and circulatory arrest on the auditory brainstem response during operation in children].
Topics: Adolescent; Adult; Aged; Aging; Brain Neoplasms; Child; Child, Preschool; Chromatography, High Press | 1991 |
[The studies of melatonin values in the cerebrospinal fluid of hydrocephalic patients].
Topics: Adolescent; Adult; Aged; Aging; Brain Neoplasms; Child; Child, Preschool; Chromatography, High Press | 1991 |
Functional recovery and collateral neuronal sprouting examined in young and aged rats following a partial neural lesion.
Topics: Aging; Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Desipramine; Functional Laterality; | 1991 |
Does a centralized clock for ageing exist?
Topics: Aging; Biological Evolution; Calcification, Physiologic; Genes, Switch; Humans; Life Expectancy; Lon | 1990 |
Developmental changes and daily rhythm in melatonin-induced inhibition of 3',5'-cyclic AMP accumulation in the rat pituitary.
Topics: Aging; Animals; Circadian Rhythm; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Gonadotr | 1990 |
The involvement of pineal gland and melatonin in immunity and aging. I. Thymus-mediated, immunoreconstituting and antiviral activity of thyrotropin-releasing hormone.
Topics: Aging; Animals; Antibody Formation; Circadian Rhythm; Encephalomyocarditis virus; Female; Male; Mela | 1990 |
Temporal effects of pinealectomy, melatonin, and photocycle reversal on age-related behavioral changes.
Topics: Aging; Animals; Behavior, Animal; Circadian Rhythm; Darkness; Light; Melatonin; Pineal Gland; Rats | 1990 |
Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease.
Topics: Adolescent; Adult; Aged; Aging; Alzheimer Disease; Circadian Rhythm; Female; Humans; Indoles; Male; | 1990 |
The pineal gland in newborn southern elephant seals, Mirounga leonina.
Topics: Aging; Animals; Animals, Newborn; Body Temperature Regulation; Body Weight; Melatonin; Organ Size; P | 1990 |
Aging-postponing effects of circadian melatonin: experimental evidence, significance and possible mechanisms.
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Pineal Gland | 1990 |
Aging alters resynchronization of the circadian system in rats after a shift of the light-dark cycle.
Topics: Acetyltransferases; Aging; Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Darkness; Light | 1990 |
The therapeutic potential for tryptophan and melatonin: possible roles in depression, sleep, Alzheimer's disease and abnormal aging.
Topics: Aging; Animals; Bipolar Disorder; Dementia; Depressive Disorder; Humans; Melatonin; Mental Disorders | 1990 |
Fluctuation of blood melatonin concentrations with age: result of changes in pineal melatonin secretion, body growth, and aging.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Body Weight; Gas Chromatography-Mass Spectrometry | 1990 |
6-sulphatoxymelatonin production in breast cancer patients.
Topics: Adult; Aged; Aging; Analysis of Variance; Biopsy; Breast Neoplasms; Circadian Rhythm; Female; Humans | 1990 |
Differential effects of photoperiodic history on the responses of gonadotrophins and prolactin to intermediate daylengths in the male Syrian hamster.
Topics: Aging; Animals; Cricetinae; Follicle Stimulating Hormone; Gonadotropins; Light; Luteinizing Hormone; | 1989 |
Aging and diurnal rhythms of pineal serotonin, 5-hydroxyindoleacetic acid, norepinephrine, dopamine and serum melatonin in the male rat.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; Circadian Rhythm; Dopamine; Hydroxyindoleaceti | 1985 |
Age, photoperiodic responses, and pineal function in meadow voles, Microtus pennsylvanicus.
Topics: Aging; Animals; Arvicolinae; Light; Male; Melatonin; Organ Size; Periodicity; Pineal Gland; Testis | 1989 |
Abnormal melatonin response to 5-methoxypsoralen in dementia.
Topics: Adult; Aged; Aging; Dementia; Depressive Disorder; Female; Furocoumarins; Humans; Male; Melatonin; M | 1989 |
Maternal transfer of photoperiodic information in Siberian hamsters. II. The nature of the maternal signal, time of signal transfer, and the effect of the maternal signal on peripubertal reproductive development in the absence of photoperiodic input.
Topics: Aging; Animals; Cricetinae; Darkness; Female; Lactation; Light; Male; Maternal-Fetal Exchange; Melat | 1989 |
Ontogenesis of pineal thyroxine 5'-deiodinase activity and plasma melatonin concentration in the rat.
Topics: Acetyltransferases; Aging; Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Iodide Peroxida | 1989 |
Age-associated changes in pineal adrenergic receptors and melatonin synthesizing enzymes in the Wistar rat.
Topics: Acetylserotonin O-Methyltransferase; Aging; Animals; Arylamine N-Acetyltransferase; Binding, Competi | 1988 |
The melatonin receptors in rat ontogenesis.
Topics: Aging; Animals; Cell Membrane; Male; Median Eminence; Melatonin; Pituitary Gland, Anterior; Rats; Ra | 1988 |
Melatonin receptors in discrete brain areas of the male rat. Impact of aging on density and on circadian rhythmicity.
Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Circadian Rhythm; Darkness; Hippocampus; Hypotha | 1988 |
The role of melatonin and serotonin in aging.
Topics: Aging; Animals; Circadian Rhythm; Humans; Melatonin; Neurotransmitter Agents; Pineal Gland; Serotoni | 1987 |
Circadian rhythms of melatonin and cortisol in aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; Body Height; Body Weight; Circadian Rhythm; Female; Humans; H | 1989 |
Melatonin secretion and age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Circadian Rhythm; Female; Humans; Male; Melatonin; Mid | 1989 |
The pineal and pubertal development.
Topics: Adolescent; Aging; Animals; Child; Circadian Rhythm; Female; Humans; Luteinizing Hormone; Male; Mela | 1985 |
Normal patterns of melatonin levels in the pineal gland and body fluids of humans and experimental animals.
Topics: Aging; Animals; Animals, Laboratory; Body Fluids; Circadian Rhythm; Darkness; Humans; Light; Melaton | 1986 |
Neuropeptide-neurotransmitter interaction due to GRF and CRF stimulation in experimental and clinical conditions during development.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Arginine Vasopressin; Corticosterone; Corticotropin-Rel | 1986 |
Delayed sexual maturation induced by daily melatonin administration eliminates the LH response to naloxone despite normal responsiveness to GnRH in juvenile male rats.
Topics: Aging; Animals; Luteinizing Hormone; Male; Melatonin; Naloxone; Pituitary Hormone-Releasing Hormones | 1988 |
Effect of neonatal melatonin administration on sexual development in the rat.
Topics: Aging; Animals; Animals, Newborn; Estradiol; Estrus; Female; Follicle Stimulating Hormone; Luteinizi | 1987 |
Short-term and long-term effects of melatonin on GnRH-stimulated gonadotropin secretion in pituitaries of sexually maturing rats.
Topics: Aging; Animals; Cells, Cultured; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Lutei | 1987 |
Stress causes an increase in endogenous monoamine oxidase inhibitor (tribulin) in rat brain.
Topics: Aging; Animals; Brain; Isatin; Male; Melatonin; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rat | 1988 |
Influence of age and splanchnic nerve on the action of melatonin in the adrenomedullary catecholamine content and blood glucose level in the avian group.
Topics: Adrenal Medulla; Aging; Animals; Birds; Blood Glucose; Catecholamines; Columbidae; Female; Homeostas | 1988 |
Melatonin synthesis in the pineal gland of the Richardson's ground squirrel (Spermophilus richardsonii): influence of age and insulin-induced hypoglycemia.
Topics: Aging; Animals; Arylamine N-Acetyltransferase; Blood Glucose; Circadian Rhythm; Female; Hypoglycemia | 1987 |
Alterations in nocturnal serum melatonin levels in humans with growth and aging.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Child, Preschool; Circadian Rhythm; Female | 1988 |
Constant pineal output and increasing body mass account for declining melatonin levels during human growth and sexual maturation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Body Constitution; Child; Child, Preschool; Femal | 1988 |
Pineal melatonin, its fundamental immunoregulatory role in aging and cancer.
Topics: Aging; Animals; Antibody Formation; Circadian Rhythm; Immunologic Memory; Longevity; Melatonin; Mice | 1988 |
The ontogeny of pineal and serum melatonin in male rats at mid-light and mid-dark.
Topics: Aging; Animals; Circadian Rhythm; Light; Male; Melatonin; Pineal Gland; Rats; Rats, Inbred Strains | 1988 |
Melatonin: data consistent with a role in controlling ovarian function.
Topics: Adult; Aging; Child; Female; Gonadotropins, Pituitary; Humans; Melatonin; Pregnanediol; Puberty, Pre | 1987 |
Changes in melatonin secretion with age and pubescence.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Infant; I | 1986 |
The pineal gland in relation to growth and development in children.
Topics: Adolescent; Aging; Animals; Arylamine N-Acetyltransferase; Biological Clocks; Bone Development; Chil | 1986 |
Developmental changes in hypothalamic melatonin levels of male rats.
Topics: Aging; Animals; Circadian Rhythm; Hypothalamus; Male; Melatonin; Pineal Gland; Rats; Seasons | 1987 |
Pineal melatonin rhythms in female Turkish hamsters: effects of photoperiod and hibernation.
Topics: Aging; Animals; Circadian Rhythm; Cricetinae; Darkness; Female; Hibernation; Light; Melatonin; Mesoc | 1986 |
Age-associated changes in the circadian rhythm of retinal N-acetylserotonin and melatonin in rats with pigmented eyes.
Topics: Aging; Animals; Circadian Rhythm; Eye Color; Male; Melatonin; Rats; Retina; Serotonin | 1986 |
Electrophysiological and endocrinological aspects of aging in the rat pineal gland.
Topics: Action Potentials; Aging; Animals; Circadian Rhythm; Male; Melatonin; Neurons; Pineal Gland; Rats; R | 1986 |
Human melatonin production decreases with age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Circadian Rhythm; Female; Humans; Light; Male; Melatonin; Mid | 1986 |
Plasma melatonin--an index of brain aging in humans?
Topics: Adult; Aged; Aging; Brain; Circadian Rhythm; Female; Humans; Male; Melatonin; Middle Aged; Radioimmu | 1986 |
Episodic secretion of melatonin in pre- and postpubertal girls and boys.
Topics: Adolescent; Aging; Child; Female; Humans; Luteinizing Hormone; Male; Melatonin; Puberty; Sex Factors | 1985 |
Neonatal steroid treatment reduces catecholamine-induced increases in pineal serotonin N-acetyltransferase activity.
Topics: Acetyltransferases; Aging; Animals; Animals, Newborn; Arylamine N-Acetyltransferase; Catecholamines; | 1985 |
Circadian rhythms in serum melatonin from infancy to adolescence.
Topics: Adolescent; Aging; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Infant; Male; Melatoni | 1985 |
[Time in the medical profession].
Topics: Aged; Aging; Circadian Rhythm; Family Practice; Humans; Melatonin; Physician Impairment; Time; Time | 1985 |
Effect of light and darkness on pineal hydroxyindole-O-methyl transferase (HIOMT) in Japanese quail.
Topics: Aging; Animals; Carbon Radioisotopes; Catechol O-Methyltransferase; Circadian Rhythm; Coturnix; Dark | 1973 |
Inhibition of rat testicular androgen synthesis in vitro by melantonin and serotonin.
Topics: Aging; Androgens; Animals; Biotransformation; Carbon Isotopes; Depression, Chemical; Fluorometry; Hy | 1972 |
Effect of melatonin upon thyroid hormone secretion rate in female hamsters and male rats.
Topics: Aging; Animals; Body Weight; Cricetinae; Depression, Chemical; Female; Iodine Isotopes; Male; Melato | 1972 |
Melatonin on endocrine DNA changes in female rats at increasing ages.
Topics: Adrenal Glands; Aging; Animals; DNA; Female; Melatonin; Organ Size; Ovary; Pituitary Gland; Rats; So | 1971 |