Page last updated: 2024-10-19

melatonin and Ache

melatonin has been researched along with Ache in 84 studies

Research Excerpts

ExcerptRelevanceReference
"This study investigated the effect of oral melatonin as a premedication before cataract surgery on pain score, anxiety, surgical conditions, and intraocular pressure (IOP) during cataract surgery with phacoemulsification under topical anesthesia."9.69The Effect of Melatonin on Analgesia, Anxiety, and Intraocular Pressure (IOP) in Cataract Surgery Under Topical Anesthesia. ( Abdelbasset, WK; Golabi, P; Haki, BK; Komilzhonovich, IN; Mahmodi, H; Morwati, S; Motarjemizadeh, Q; Rahmani, N; Sane, S; Suksatan, W; Zaman, GS, 2023)
"Melatonin did not reduce preoperative anxiety in patients undergoing hernia repair."9.51Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial. ( Gram-Hanssen, A; Holm, MA; Madsen, BK; Rosenberg, J; Zetner, DB, 2022)
" All preterm neonates with gestational age (GA) < 34 weeks or birth weight (BW) < 2000 grams eligible for ROP screening were randomized into oral melatonin (4 mg/kg) and oral 24% sucrose (0."9.51Comparison between oral melatonin and 24% sucrose for pain management during retinopathy of prematurity screening: a randomized controlled trial. ( Behura, SS; Dhanawat, A; Nayak, B; Panda, SK, 2022)
" In experiment 1, all animals were injected with complete Freund's adjuvant (CFA) to induce inflammation and were randomly allocated to receiving melatonin (60 mg/kg) or vehicle."9.20Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain. ( Caumo, W; Laste, G; Lucena da Silva Torres, I; Ripoll Rozisky, J, 2015)
"Melatonin alone or in combination with amitriptyline reduced significantly pain on the VAS compared with amitriptyline alone (P < 0."9.19Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. ( Caumo, W; de Souza, IC; de Zanette, SA; Deitos, A; Laste, G; Machado, CB; Rozisky, JR; Schwertner, A; Torres, IL; Vercelino, R; Xavier, F, 2014)
"The objective was to evaluate the analgesic dose response of the effects of melatonin on pressure and heat pain threshold and tolerance and the sedative effects."9.17A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects. ( Caumo, W; Fregni, F; Markus, R; Muller, S; Razzolini, B; Rozisky, JR; Stefani, LC; Torres, IL, 2013)
"Melatonin significantly reduced the anxiety scores (median, interquartile range) from 5 and 5-3 to 3 and 2-4 after premedication and to 3 and 2-3 during surgery and to 0 and 0-1 postoperatively before discharge from the recovery room."9.17The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia. ( Khezri, MB; Merate, H, 2013)
"The aim of the study was to determine the possible effect of melatonin treatment on disturbed sleep, fatigue and pain symptoms observed in fibromyalgia (FM) patients."9.09The effect of melatonin in patients with fibromyalgia: a pilot study. ( Arias, MA; Brusco, LI; Cardinalli, DP; Citera, G; Lázaro, MA; Maldonado-Cocco, JA; Rosemffet, MG; Scheines, EJ, 2000)
"The antinociceptive effect of melatonin has been evaluated in diverse pain models, and several findings show that melatonin receptors modulate pain mechanisms as activation induces an antinociceptive effect at spinal and supraspinal levels under conditions of acute and inflammatory pain."8.85Melatonin: a hormone that modulates pain. ( Ambriz-Tututi, M; Cruz, SL; Granados-Soto, V; Rocha-González, HI, 2009)
"Melatonin improved mood, anxiety levels, and quality of life while decreasing cortisol levels in patients with fibromyalgia."7.91Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia. ( Castaño, MY; Garrido, M; Gómez, MÁ; Rodríguez, AB, 2019)
"We assessed the therapeutic effect of exogenous melatonin (MEL), dexamethasone (DEXA), and a combination of both on nociceptive response induced by chronic inflammation and on the rest-activity circadian rhythm in rats."7.79Melatonin treatment entrains the rest-activity circadian rhythm in rats with chronic inflammation. ( Caumo, W; de Macedo, IC; de Souza, A; de Souza, IC; Laste, G; Medeiros, L; Meurer, L; Rozisky, JR; Torres, IL; Vidor, L, 2013)
"To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin (6-OHMS), in functional dyspepsia (FD)."7.77Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia. ( Blasiak, J; Chojnacki, C; Chojnacki, J; Klupinska, G; Poplawski, T; Reiter, RJ, 2011)
"Effect of melatonin (25-100 mg/kg, ip) and its interaction with putative melatonin receptor antagonists and opioidergic and serotoninergic agents have been studied in formalin test, a model of tonic continuous pain."7.72Evaluation of the role of melatonin in formalin-induced pain response in mice. ( Mahajan, P; Mediratta, PK; Ray, M; Sharma, KK, 2004)
"The objective of this study was to test the effect of melatonin on thermal pain threshold in female patients with eating disorders."7.71Pain modulation role of melatonin in eating disorders. ( Nedvídková, J; Papezová, H; Yamamotová, A, 2001)
"The cyclic recurrence of cluster periods and the regular timing of headache occurrence in cluster headache (CH) induced us to study the circadian secretion of melatonin and cortisol in 12 patients with episodic CH, during a cluster period, and compare them with 7 age- and sex-matched healthy controls."7.69Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache. ( Bussone, G; D'Amico, D; Fraschini, F; Leone, M; Lucini, V; Maltempo, C; Moschiano, F, 1995)
"The aim of the present study was to investigate the discriminative power of a series of variables (including determination of depressive symptomatology by means of a visual analogue scale, determination of personality traits by means of the Karolinska Scales of Personality, determination of monoamine metabolites in CSF, platelet MAO activities, serum cortisol before and after dexamethasone suppression and urinary melatonin) in differentiating chronic pain patients from healthy subjects, and patients with idiopathic pain syndromes from patients with neurogenic pain syndromes."7.67Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin. ( Almay, BG; Häggendal, J; Johansson, F; Oreland, L; von Knorring, L; Wetterberg, L, 1986)
"In 16 healthy volunteers, 16 patients with neurogenic pain syndromes, 37 patients with idiopathic pain syndromes, and 30 depressed patients, melatonin in serum was determined at 2 a."7.67Melatonin in serum and urine in patients with idiopathic pain syndromes. ( Almay, BG; von Knorring, L; Wetterberg, L, 1987)
"Melatonin is a neurohormone secreted by the pineal gland with antioxidant and anti-inflammatory functions."6.82Potential benefits of melatonin to control pain in ventilated preterm newborns: An updated review. ( Cannavò, L; Di Rosa, G; Gitto, E; Marseglia, L; Perrone, S; Viola, V, 2022)
"Pain during the BI and secondary hyperalgesia areas were defined as primary outcomes."6.80Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study. ( Andersen, LPH; Fenger, AQ; Gögenur, I; Petersen, MC; Rosenberg, J; Werner, MU, 2015)
"Endotracheal intubation is a common painful procedure in newborn care."6.77Pain in neonatal intensive care: role of melatonin as an analgesic antioxidant. ( Arrigo, T; Aversa, S; Barberi, I; Gitto, E; Pellegrino, S; Reiter, RJ; Salpietro, CD; Trimarchi, G, 2012)
"Melatonin is a well-known jet-lag compound, which helps in entrainment of sleep cycle."5.72Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage. ( Huang, ACW; Kaur, T; Shih, HC; Shyu, BC, 2022)
"This study investigated the effect of oral melatonin as a premedication before cataract surgery on pain score, anxiety, surgical conditions, and intraocular pressure (IOP) during cataract surgery with phacoemulsification under topical anesthesia."5.69The Effect of Melatonin on Analgesia, Anxiety, and Intraocular Pressure (IOP) in Cataract Surgery Under Topical Anesthesia. ( Abdelbasset, WK; Golabi, P; Haki, BK; Komilzhonovich, IN; Mahmodi, H; Morwati, S; Motarjemizadeh, Q; Rahmani, N; Sane, S; Suksatan, W; Zaman, GS, 2023)
"Melatonin did not reduce preoperative anxiety in patients undergoing hernia repair."5.51Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial. ( Gram-Hanssen, A; Holm, MA; Madsen, BK; Rosenberg, J; Zetner, DB, 2022)
"Explore sleep disturbance in postoperative orthopedic trauma patients and determine the impact of melatonin supplementation on postoperative sleep, pain, and quality of life."5.51Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial. ( Bishop, J; Calderon, C; Fithian, A; Gardner, M; Schultz, B; Segovia, N; Tanner, N, 2022)
" All preterm neonates with gestational age (GA) < 34 weeks or birth weight (BW) < 2000 grams eligible for ROP screening were randomized into oral melatonin (4 mg/kg) and oral 24% sucrose (0."5.51Comparison between oral melatonin and 24% sucrose for pain management during retinopathy of prematurity screening: a randomized controlled trial. ( Behura, SS; Dhanawat, A; Nayak, B; Panda, SK, 2022)
"Melatonin responses were abolished by simultaneous administration of the antagonists, 2-phenylmelatonin and luzindole and were unaffected by the MT2 antagonist 4-phenyl-2-propionamidotetralin."5.32Gene expression and functional characterization of melatonin receptors in the spinal cord of the rat: implications for pain modulation. ( Berger, E; Lansmann, T; Musshoff, U; Speckmann, EJ; Zahn, PK, 2003)
"Melatonin has been shown to play a role in antioxidative defence."5.31Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat? ( Holecek, V; Parara, S; Pekárková, I; Racek, J; Rokyta, R; Stopka, P; Trefil, L, 2001)
" In experiment 1, all animals were injected with complete Freund's adjuvant (CFA) to induce inflammation and were randomly allocated to receiving melatonin (60 mg/kg) or vehicle."5.20Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain. ( Caumo, W; Laste, G; Lucena da Silva Torres, I; Ripoll Rozisky, J, 2015)
"Melatonin alone or in combination with amitriptyline reduced significantly pain on the VAS compared with amitriptyline alone (P < 0."5.19Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. ( Caumo, W; de Souza, IC; de Zanette, SA; Deitos, A; Laste, G; Machado, CB; Rozisky, JR; Schwertner, A; Torres, IL; Vercelino, R; Xavier, F, 2014)
"Melatonin significantly reduced the anxiety scores (median, interquartile range) from 5 and 5-3 to 3 and 2-4 after premedication and to 3 and 2-3 during surgery and to 0 and 0-1 postoperatively before discharge from the recovery room."5.17The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia. ( Khezri, MB; Merate, H, 2013)
"This study provides additional evidence supporting the analgesic effects of melatonin on pain scores and analgesic consumption in patients with mild-to-moderate chronic myofascial TMD pain."5.17Analgesic and sedative effects of melatonin in temporomandibular disorders: a double-blind, randomized, parallel-group, placebo-controlled study. ( Caumo, W; Custódio de Souza, IC; Fregni, F; Torres, IL; Vidor, LP, 2013)
"The objective was to evaluate the analgesic dose response of the effects of melatonin on pressure and heat pain threshold and tolerance and the sedative effects."5.17A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects. ( Caumo, W; Fregni, F; Markus, R; Muller, S; Razzolini, B; Rozisky, JR; Stefani, LC; Torres, IL, 2013)
"Melatonin is an effective premedication before IVRA since it reduced patient anxiety, decreased tourniquet-related pain, and improved perioperative analgesia."5.13Melatonin improves tourniquet tolerance and enhances postoperative analgesia in patients receiving intravenous regional anesthesia. ( Ismail, SA; Mowafi, HA, 2008)
"The aim of the study was to determine the possible effect of melatonin treatment on disturbed sleep, fatigue and pain symptoms observed in fibromyalgia (FM) patients."5.09The effect of melatonin in patients with fibromyalgia: a pilot study. ( Arias, MA; Brusco, LI; Cardinalli, DP; Citera, G; Lázaro, MA; Maldonado-Cocco, JA; Rosemffet, MG; Scheines, EJ, 2000)
"Melatonin, the main hormone of the pineal gland, possesses analgesic properties, which were observed on various experimental models of pain and in the clinical practice."4.88[Analgesic properties of pineal hormone melatonin]. ( Arushanian, ÉB, 2012)
"The antinociceptive effect of melatonin has been evaluated in diverse pain models, and several findings show that melatonin receptors modulate pain mechanisms as activation induces an antinociceptive effect at spinal and supraspinal levels under conditions of acute and inflammatory pain."4.85Melatonin: a hormone that modulates pain. ( Ambriz-Tututi, M; Cruz, SL; Granados-Soto, V; Rocha-González, HI, 2009)
"Age, APACHE score at ICU admission, neurological disease, sepsis and duration of mechanical ventilation were all independent risk factors for the development of delirium in ICU patients."4.40Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023)
"Melatonin improved mood, anxiety levels, and quality of life while decreasing cortisol levels in patients with fibromyalgia."3.91Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia. ( Castaño, MY; Garrido, M; Gómez, MÁ; Rodríguez, AB, 2019)
"Morphine is a widely used analgesic for various types of pain."3.85Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats. ( Fan, Y; Liang, X; Song, L; Wang, R, 2017)
"We assessed the therapeutic effect of exogenous melatonin (MEL), dexamethasone (DEXA), and a combination of both on nociceptive response induced by chronic inflammation and on the rest-activity circadian rhythm in rats."3.79Melatonin treatment entrains the rest-activity circadian rhythm in rats with chronic inflammation. ( Caumo, W; de Macedo, IC; de Souza, A; de Souza, IC; Laste, G; Medeiros, L; Meurer, L; Rozisky, JR; Torres, IL; Vidor, L, 2013)
"To further understand the relationship between melatonin (MT) and deltorphins (Dels) in pain modulation, two chimeric peptides (Del I-5-methoxytryptamine and Del II-5-methoxytryptamine) both containing 5-methoxytryptamine at the carboxyl-terminal of Dels mimicking MT were designed, synthesized and characterized by tail-flick assay in mice."3.77Preliminary analgesic properties of deltorphin-5-methoxytryptamine chimeric opioid peptides. ( Dong, S; Jin, Q; Li, M; Wang, J; Wang, L, 2011)
"To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin (6-OHMS), in functional dyspepsia (FD)."3.77Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia. ( Blasiak, J; Chojnacki, C; Chojnacki, J; Klupinska, G; Poplawski, T; Reiter, RJ, 2011)
"Effect of melatonin (25-100 mg/kg, ip) and its interaction with putative melatonin receptor antagonists and opioidergic and serotoninergic agents have been studied in formalin test, a model of tonic continuous pain."3.72Evaluation of the role of melatonin in formalin-induced pain response in mice. ( Mahajan, P; Mediratta, PK; Ray, M; Sharma, KK, 2004)
"The objective of this study was to test the effect of melatonin on thermal pain threshold in female patients with eating disorders."3.71Pain modulation role of melatonin in eating disorders. ( Nedvídková, J; Papezová, H; Yamamotová, A, 2001)
"The cyclic recurrence of cluster periods and the regular timing of headache occurrence in cluster headache (CH) induced us to study the circadian secretion of melatonin and cortisol in 12 patients with episodic CH, during a cluster period, and compare them with 7 age- and sex-matched healthy controls."3.69Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache. ( Bussone, G; D'Amico, D; Fraschini, F; Leone, M; Lucini, V; Maltempo, C; Moschiano, F, 1995)
"Subcutaneous injection of formaldehyde into mouse hind paw elicited pain responses consisting of licking or biting of the paw, which were observed biphasically."3.67Effect of neurotropin on hyperalgesia induced by prostaglandin E2, naloxone, melatonin and dark condition in mice. ( Inoki, R; Ohkubo, T; Saito, K; Shibata, M; Takahashi, H, 1987)
"Circadian rhythms for cortisol, 6-sulphatoxy melatonin and core body temperature were compared in control subjects and patients with functional abdominal pain."3.67Circadian rhythms in patients with abdominal pain syndromes. ( Kennaway, DJ; Knight, RE; Pannall, PR; Roberts-Thomson, IC, 1988)
"In 16 healthy volunteers, 16 patients with neurogenic pain syndromes, 37 patients with idiopathic pain syndromes, and 30 depressed patients, melatonin in serum was determined at 2 a."3.67Melatonin in serum and urine in patients with idiopathic pain syndromes. ( Almay, BG; von Knorring, L; Wetterberg, L, 1987)
"The aim of the present study was to investigate the discriminative power of a series of variables (including determination of depressive symptomatology by means of a visual analogue scale, determination of personality traits by means of the Karolinska Scales of Personality, determination of monoamine metabolites in CSF, platelet MAO activities, serum cortisol before and after dexamethasone suppression and urinary melatonin) in differentiating chronic pain patients from healthy subjects, and patients with idiopathic pain syndromes from patients with neurogenic pain syndromes."3.67Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin. ( Almay, BG; Häggendal, J; Johansson, F; Oreland, L; von Knorring, L; Wetterberg, L, 1986)
"Different treatments, durations and cancer types were the main sources of heterogeneity."2.82Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials. ( Bu, X; Chen, H; Fan, R; Li, X; Tan, Y; Wang, T; Yang, S, 2022)
"Melatonin is a neurohormone secreted by the pineal gland with antioxidant and anti-inflammatory functions."2.82Potential benefits of melatonin to control pain in ventilated preterm newborns: An updated review. ( Cannavò, L; Di Rosa, G; Gitto, E; Marseglia, L; Perrone, S; Viola, V, 2022)
"Pain during the BI and secondary hyperalgesia areas were defined as primary outcomes."2.80Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study. ( Andersen, LPH; Fenger, AQ; Gögenur, I; Petersen, MC; Rosenberg, J; Werner, MU, 2015)
"Endotracheal intubation is a common painful procedure in newborn care."2.77Pain in neonatal intensive care: role of melatonin as an analgesic antioxidant. ( Arrigo, T; Aversa, S; Barberi, I; Gitto, E; Pellegrino, S; Reiter, RJ; Salpietro, CD; Trimarchi, G, 2012)
"Age, gender, and co-morbidities such as migraine seem to influence the prevalence of PSH."2.61Primary Stabbing Headache. ( Dilli, E; Murray, D, 2019)
"Pain is a multidimensional response involving several levels of expression ranging from somatosensory to emotional."2.50Restless legs syndrome and pain disorders: what's in common? ( Delgado Rodrigues, RN; Goulart, LI; Prieto Peres, MF, 2014)
"Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties."2.47Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies. ( Amirian, I; Gögenur, I; Reiter, RJ; Rosenberg, J; Wilhelmsen, M, 2011)
" Additional well designed randomized controlled trials are necessary to compare melatonin premedication with other pharmacological interventions, investigate its effect on more varied surgical populations, and to delineate its optimal dosing regimen."2.46Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials. ( Abrishami, A; Chung, F; Seet, E; Venkatraghavan, L; Yousaf, F, 2010)
"Melatonin is a remarkable molecule with diverse physiological functions."2.46Potential use of melatonergic drugs in analgesia: mechanisms of action. ( Brown, GM; Cardinali, DP; Moscovitch, A; Pandi-Perumal, SR; Spence, DW; Srinivasan, V; Trakht, I, 2010)
"Melatonin is a widely distributed and important signal molecule that occurs in unicellular organisms, plants, and fungi in addition to animals and humans."2.45Chapter 16: Melatonin and nerve regeneration. ( Kaplan, S; Odaci, E, 2009)
"How melatonin affects cancer remains largely unclear."2.44Neurobiological effects of melatonin as related to cancer. ( Hoang, BX; Levine, SA; Pham, PT; Shaw, DG, 2007)
"Pain is a multi-dimensional process involving the physical, emotional and perceptual integration of noxious information."2.42Pain in the brain: are hormones to blame? ( Blackburn-Munro, G; Blackburn-Munro, R, 2003)
"Melatonin is a well-known jet-lag compound, which helps in entrainment of sleep cycle."1.72Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage. ( Huang, ACW; Kaur, T; Shih, HC; Shyu, BC, 2022)
"Pain is one of the most common medical challenges, reducing life quality."1.56The antinociceptive mechanisms of melatonin: role of L-arginine/nitric oxide/cyclic GMP/KATP channel signaling pathway. ( Abbaszadeh, F; Ahmadpour, Y; Fakhri, S; Ghanbarveisi, F; Gravandi, MM; Iranpanah, A; Kooshki, L; Moradi, SZ; Rezaei, H, 2020)
"Pain was assessed using the formalin test (induced by a subcutaneous injection of 50 microl of a 5% formalin solution to the hindpaw)."1.35Evaluation for the interaction between intrathecal melatonin and clonidine or neostigmine on formalin-induced nociception. ( Huang, LJ; Kim, WM; Kim, YO; Lee, HG; Park, HC; Yoon, MH, 2008)
"Pretreatment with melatonin also reduced the number of Fos and nitric oxide synthase immunoreactive cells in the trigeminal nucleus caudalis."1.33Melatonin inhibits cortical spreading depression-evoked trigeminal nociception. ( le Grand, SM; Patumraj, S; Phansuwan-Pujito, P; Srikiatkhachorn, A, 2006)
"Melatonin responses were abolished by simultaneous administration of the antagonists, 2-phenylmelatonin and luzindole and were unaffected by the MT2 antagonist 4-phenyl-2-propionamidotetralin."1.32Gene expression and functional characterization of melatonin receptors in the spinal cord of the rat: implications for pain modulation. ( Berger, E; Lansmann, T; Musshoff, U; Speckmann, EJ; Zahn, PK, 2003)
"Acute inflammation was induced by sub-plantar injection of carrageenan (1%) in the rat hind paw."1.31Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Batran, S; El-Shenawy, SM, 2002)
"Melatonin has been shown to play a role in antioxidative defence."1.31Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat? ( Holecek, V; Parara, S; Pekárková, I; Racek, J; Rokyta, R; Stopka, P; Trefil, L, 2001)

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-19905 (5.95)18.7374
1990's5 (5.95)18.2507
2000's33 (39.29)29.6817
2010's30 (35.71)24.3611
2020's11 (13.10)2.80

Authors

AuthorsStudies
Liu, H1
Altenbach, RJ1
Carr, TL1
Chandran, P1
Hsieh, GC1
Lewis, LG1
Manelli, AM1
Milicic, I1
Marsh, KC1
Miller, TR1
Strakhova, MI1
Vortherms, TA1
Wakefield, BD1
Wetter, JM1
Witte, DG1
Honore, P1
Esbenshade, TA1
Brioni, JD1
Cowart, MD1
Stangeland, H1
Handal, M1
Skurtveit, SO1
Aakvaag, HF1
Dyb, G1
Wentzel-Larsen, T1
Baumann-Larsen, M1
Zwart, JA1
Storheim, K1
Stensland, SØ1
Kaur, T1
Shih, HC1
Huang, ACW1
Shyu, BC1
Fan, R1
Bu, X1
Yang, S1
Tan, Y1
Wang, T1
Chen, H1
Li, X1
Holm, MA1
Gram-Hanssen, A1
Madsen, BK1
Zetner, DB1
Rosenberg, J4
Sane, S1
Motarjemizadeh, Q1
Komilzhonovich, IN1
Abdelbasset, WK1
Zaman, GS1
Suksatan, W1
Morwati, S1
Haki, BK1
Rahmani, N1
Golabi, P1
Mahmodi, H1
Tanner, N3
Schultz, B3
Calderon, C3
Fithian, A3
Segovia, N3
Bishop, J3
Gardner, M3
Behura, SS1
Dhanawat, A1
Nayak, B1
Panda, SK1
Hemati, K1
Amini Kadijani, A1
Sayehmiri, F1
Mehrzadi, S1
Zabihiyeganeh, M1
Hosseinzadeh, A1
Mirzaei, A1
Fakhri, S1
Ahmadpour, Y1
Rezaei, H1
Kooshki, L1
Moradi, SZ1
Iranpanah, A1
Gravandi, MM1
Abbaszadeh, F1
Ghanbarveisi, F1
Cannavò, L1
Perrone, S1
Marseglia, L2
Viola, V1
Di Rosa, G1
Gitto, E3
Fan, Y1
Liang, X1
Wang, R1
Song, L1
Keshavarzi, F1
Mahmoudzadeh, F1
Brand, S1
Sadeghi Bahmani, D1
Akbari, F1
Khazaie, H1
Ghadami, MR1
Castaño, MY1
Garrido, M1
Rodríguez, AB1
Gómez, MÁ1
Murray, D1
Dilli, E1
Srinivasan, V2
Zakaria, R1
Jeet Singh, H1
Acuna-Castroviejo, D1
Khezri, MB1
Merate, H1
Laste, G3
Vidor, L1
de Macedo, IC1
Rozisky, JR3
Medeiros, L1
de Souza, A1
Meurer, L1
de Souza, IC2
Torres, IL4
Caumo, W5
Andersen, LP2
Gögenur, I3
Phiphatwatcharaded, C1
Topark-Ngarm, A1
Puthongking, P1
Mahakunakorn, P1
de Zanette, SA1
Vercelino, R1
Schwertner, A1
Machado, CB1
Xavier, F1
Deitos, A1
Fang, X1
Seim, I1
Huang, Z1
Gerashchenko, MV1
Xiong, Z1
Turanov, AA1
Zhu, Y1
Lobanov, AV1
Fan, D1
Yim, SH1
Yao, X1
Ma, S1
Yang, L1
Lee, SG1
Kim, EB1
Bronson, RT1
Šumbera, R1
Buffenstein, R1
Zhou, X1
Krogh, A1
Park, TJ1
Zhang, G1
Wang, J2
Gladyshev, VN1
Goulart, LI1
Delgado Rodrigues, RN1
Prieto Peres, MF1
D'Angelo, G1
Manti, S1
Aversa, S2
Arrigo, T2
Reiter, RJ5
Ripoll Rozisky, J1
Lucena da Silva Torres, I1
Stefani, LC1
Muller, S1
Razzolini, B1
Fregni, F2
Markus, R1
Andersen, LPH1
Fenger, AQ1
Petersen, MC1
Werner, MU1
Zhuravlev, BV1
Murtazina, EP1
Pertsov, SS1
R T Ramirez, R1
Poling, MI1
deCourten, JF1
Chamberlain, RL1
Hernández-Pacheco, A1
Araiza-Saldaña, CI2
Granados-Soto, V4
Mixcoatl-Zecuatl, T2
Mowafi, HA1
Ismail, SA1
Makay, B1
Yoon, MH2
Park, HC1
Kim, WM1
Lee, HG1
Kim, YO1
Huang, LJ1
Ambriz-Tututi, M3
Rocha-González, HI2
Cruz, SL1
Bruhn, C1
Odaci, E1
Kaplan, S1
Pandi-Perumal, SR1
Spence, DW1
Moscovitch, A1
Trakht, I1
Brown, GM1
Cardinali, DP1
Yousaf, F1
Seet, E1
Venkatraghavan, L1
Abrishami, A1
Chung, F1
Wang, L1
Li, M1
Jin, Q1
Dong, S1
Shin, DJ1
Jeong, CW1
Lee, SH1
Wilhelmsen, M1
Amirian, I1
Chojnacki, C1
Poplawski, T1
Klupinska, G1
Blasiak, J1
Chojnacki, J1
Horváth, G1
Mécs, L1
Perrig, S1
Espa-Cervena, K1
Pépin, JL1
Salpietro, CD1
Barberi, I1
Trimarchi, G1
Pellegrino, S1
Arushanian, ÉB1
Vidor, LP1
Custódio de Souza, IC1
El-Shenawy, SM1
Abdel-Salam, OM1
Baiuomy, AR1
El-Batran, S1
Arbid, MS1
Govitrapong, P2
Sawlom, S1
Ebadi, M3
Blackburn-Munro, G1
Blackburn-Munro, R1
Zahn, PK1
Lansmann, T1
Berger, E1
Speckmann, EJ1
Musshoff, U1
Ray, M1
Mediratta, PK1
Mahajan, P1
Sharma, KK1
Tu, Y1
Sun, RQ1
Willis, WD1
Perissin, L1
Boccalon, S1
Scaggiante, B1
Petrelli, L1
Ortolani, F1
Porro, CA1
Rokyta, R3
Stopka, P2
Holecek, V3
Krikava, K1
Pekárková, I2
Onal, SA1
Inalkac, S1
Kutlu, S1
Kelestimur, H1
Mistraletti, G1
Donatelli, F1
Carli, F1
Lahiri, DK1
Chen, DM1
Lahiri, P1
Bondy, S1
Greig, NH1
Mantovani, M1
Kaster, MP1
Pertile, R1
Calixto, JB1
Rodrigues, AL1
Santos, AR1
le Grand, SM1
Patumraj, S1
Phansuwan-Pujito, P2
Srikiatkhachorn, A1
Wolkove, N1
Elkholy, O1
Baltzan, M1
Palayew, M1
Arreola-Espino, R1
Urquiza-Marín, H1
Caram-Salas, NL1
Hoang, BX1
Shaw, DG1
Pham, PT1
Levine, SA1
Leone, M1
Lucini, V1
D'Amico, D1
Moschiano, F1
Maltempo, C1
Fraschini, F1
Bussone, G1
Sandyk, R2
Dann, LC1
Nelson, F1
De Bleecker, JL1
Lamont, BH1
Verstraete, AG1
Schelfhout, VJ1
Citera, G1
Arias, MA1
Maldonado-Cocco, JA1
Lázaro, MA1
Rosemffet, MG1
Brusco, LI1
Scheines, EJ1
Cardinalli, DP1
Yu, CX2
Zhu, B1
Xu, SF1
Cao, XD2
Wu, GC2
Klerman, EB1
Goldenberg, DL1
Brown, EN1
Maliszewski, AM1
Adler, GK1
Papezová, H1
Yamamotová, A1
Nedvídková, J1
Nelson, FA1
Farr, LA1
Zhou, MM1
Wang, MZ1
Konecná, I1
Racek, J2
Trefil, L2
Parara, S1
Ying, SW1
Huang, ZQ1
von Knorring, L2
Almay, BG2
Häggendal, J1
Johansson, F1
Oreland, L1
Wetterberg, L2
Roberts-Thomson, IC1
Knight, RE1
Kennaway, DJ1
Pannall, PR1
Takahashi, H1
Shibata, M1
Ohkubo, T1
Saito, K1
Inoki, R1

Clinical Trials (13)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Killing Pain - Use of Analgesic, Sedative and Anxiolytic Medication and the Development of Psychiatric Illness in Adolescents[NCT04336605]25,000 participants (Actual)Observational [Patient Registry]2020-02-01Active, not recruiting
Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309]Phase 325 participants (Actual)Interventional2016-07-31Completed
The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy[NCT03115034]Phase 460 participants (Actual)Interventional2016-06-01Completed
The Adjunctive Use of Systemic Melatonin Therapy in the Treatment of Periodontitis Associated With Obesity (Clinical and Immunological Study).[NCT04788979]Phase 1/Phase 280 participants (Anticipated)Interventional2021-04-01Not yet recruiting
Phase II Role of Immune-pineal Axis in Fibromyalgia: Noradrenergic Modulation and Chronotherapeutic Aspects[NCT02041455]Phase 2/Phase 366 participants (Anticipated)Interventional2010-06-30Recruiting
Effects of Oral Melatonin on Neurosensory Recovery Following Facial Osteotomies - A Randomised, Controlled Clinical Trial[NCT02889432]Phase 240 participants (Anticipated)Interventional2016-06-30Recruiting
The Therapeutic Effect of Melatonin in Pediatric Patients With Functional Dyspepsia[NCT04684199]14 participants (Actual)Interventional2014-08-31Completed
Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery[NCT04791943]Phase 260 participants (Anticipated)Interventional2021-05-12Recruiting
CHOCOlate MeLatonin for AdolescenT MigrainE: The CHOCOLATE Study[NCT03597529]Phase 284 participants (Actual)Interventional2017-09-25Completed
SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477]40 participants (Anticipated)Interventional2024-07-31Not yet recruiting
The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol in Mechanically Ventilated Traumatic Brain Injury Patient: RCT[NCT04034771]Phase 338 participants (Actual)Interventional2018-01-01Completed
The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery: a Prospective Randomised Controlled Cohort Study[NCT02424071]Phase 460 participants (Actual)Interventional2015-07-31Completed
Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465]50 participants (Actual)Interventional2012-02-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Mean Visual Analog Scale (VAS) Score

Visual Analog Scale (VAS) score ranges from 0-10, measured in cm, 0 indicating no pain and 10 indicating the worst pain. (NCT03597529)
Timeframe: Baseline (Time 0) and 2 hours

Interventioncm (Mean)
Low-Dose Melatonin (mg)-2.3
High-Dose Melatonin (mg)-2.7

Perioperative Sleep Efficiency

Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery

Interventionminutes (Mean)
Study: Melatonin20
Control: Placebo-55

Reviews

25 reviews available for melatonin and Ache

ArticleYear
Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials.
    BMJ open, 2022, 09-14, Volume: 12, Issue:9

    Topics: Adult; Fatigue; Humans; Melatonin; Neoplasms; Pain; Quality of Life; Randomized Controlled Trials as

2022
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Melatonin in the treatment of fibromyalgia symptoms: A systematic review.
    Complementary therapies in clinical practice, 2020, Volume: 38

    Topics: Fatigue; Fibromyalgia; Humans; Melatonin; Pain; Randomized Controlled Trials as Topic

2020
Potential benefits of melatonin to control pain in ventilated preterm newborns: An updated review.
    Pain practice : the official journal of World Institute of Pain, 2022, Volume: 22, Issue:2

    Topics: Analgesics; Antioxidants; Humans; Infant; Infant, Newborn; Infant, Premature; Melatonin; Pain

2022
Primary Stabbing Headache.
    Current neurology and neuroscience reports, 2019, 06-08, Volume: 19, Issue:7

    Topics: Comorbidity; Diagnosis, Differential; Female; Headache Disorders, Primary; Humans; Indomethacin; Mal

2019
Melatonin and its agonists in pain modulation and its clinical application.
    Archives italiennes de biologie, 2012, Volume: 150, Issue:4

    Topics: Animals; Humans; Melatonin; Nociception; Pain; Pain Perception; Receptors, Melatonin

2012
Restless legs syndrome and pain disorders: what's in common?
    Current pain and headache reports, 2014, Volume: 18, Issue:11

    Topics: Calcium Channel Blockers; Diagnosis, Differential; Dopamine Agonists; Fibromyalgia; gamma-Aminobutyr

2014
Analgesic, anxiolytic and anaesthetic effects of melatonin: new potential uses in pediatrics.
    International journal of molecular sciences, 2015, Jan-06, Volume: 16, Issue:1

    Topics: Analgesics; Anesthetics, General; Anti-Anxiety Agents; Anxiety Disorders; Brain Diseases; Child; Ele

2015
The analgesic effects of exogenous melatonin in humans.
    Danish medical journal, 2016, Volume: 63, Issue:10

    Topics: Administration, Topical; Central Nervous System Depressants; Humans; Melatonin; Pain; Treatment Outc

2016
Melatonin: a hormone that modulates pain.
    Life sciences, 2009, Apr-10, Volume: 84, Issue:15-16

    Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio

2009
Melatonin: a hormone that modulates pain.
    Life sciences, 2009, Apr-10, Volume: 84, Issue:15-16

    Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio

2009
Melatonin: a hormone that modulates pain.
    Life sciences, 2009, Apr-10, Volume: 84, Issue:15-16

    Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio

2009
Melatonin: a hormone that modulates pain.
    Life sciences, 2009, Apr-10, Volume: 84, Issue:15-16

    Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio

2009
Melatonin: a hormone that modulates pain.
    Life sciences, 2009, Apr-10, Volume: 84, Issue:15-16

    Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio

2009
Melatonin: a hormone that modulates pain.
    Life sciences, 2009, Apr-10, Volume: 84, Issue:15-16

    Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio

2009
Melatonin: a hormone that modulates pain.
    Life sciences, 2009, Apr-10, Volume: 84, Issue:15-16

    Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio

2009
Melatonin: a hormone that modulates pain.
    Life sciences, 2009, Apr-10, Volume: 84, Issue:15-16

    Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio

2009
Melatonin: a hormone that modulates pain.
    Life sciences, 2009, Apr-10, Volume: 84, Issue:15-16

    Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio

2009
Chapter 16: Melatonin and nerve regeneration.
    International review of neurobiology, 2009, Volume: 87

    Topics: Animals; Humans; Melatonin; Nerve Regeneration; Optic Nerve; Pain; Peripheral Nerve Injuries; Periph

2009
Potential use of melatonergic drugs in analgesia: mechanisms of action.
    Brain research bulletin, 2010, Mar-16, Volume: 81, Issue:4-5

    Topics: Analgesics; Animals; Humans; Melatonin; Pain; Receptors, Melatonin

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
    Anesthesiology, 2010, Volume: 113, Issue:4

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female

2010
Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies.
    Journal of pineal research, 2011, Volume: 51, Issue:3

    Topics: Analgesics; Animals; Disease Models, Animal; Fibromyalgia; Humans; Irritable Bowel Syndrome; Male; M

2011
Antinociception by endogenous ligands at peripheral level.
    Ideggyogyaszati szemle, 2011, Mar-30, Volume: 64, Issue:5-6

    Topics: Analgesics, Opioid; Animals; Annexin A1; beta-Endorphin; Cytokines; Endorphins; Excitatory Amino Aci

2011
[Analgesic properties of pineal hormone melatonin].
    Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:8

    Topics: Analgesics; Animals; Antioxidants; Humans; Hyperalgesia; Melatonin; Mice; Pain; Pineal Gland; Rats

2012
Pain in the brain: are hormones to blame?
    Trends in endocrinology and metabolism: TEM, 2003, Volume: 14, Issue:1

    Topics: Adrenal Glands; Affect; Animals; Brain; Chronic Disease; Female; Growth Hormone; Hormones; Humans; H

2003
Metabolic and endocrine effects of sedative agents.
    Current opinion in critical care, 2005, Volume: 11, Issue:4

    Topics: Adrenergic alpha-Agonists; Analgesics; Analgesics, Opioid; Benzodiazepines; Catecholamines; Combined

2005
Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases.
    Annals of the New York Academy of Sciences, 2005, Volume: 1056

    Topics: Aging; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Cell Physiological Phenomena; Cho

2005
Sleep and aging: 2. Management of sleep disorders in older people.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2007, May-08, Volume: 176, Issue:10

    Topics: Adjuvants, Immunologic; Aged; Aging; Antidepressive Agents; Behavior Therapy; Benzodiazepines; Demen

2007
Neurobiological effects of melatonin as related to cancer.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2007, Volume: 16, Issue:6

    Topics: Aging; Antineoplastic Agents; Biological Clocks; Clinical Trials as Topic; Drug Evaluation, Preclini

2007
Resolution of Lhermitte's sign in multiple sclerosis by treatment with weak electromagnetic fields.
    The International journal of neuroscience, 1995, Volume: 81, Issue:3-4

    Topics: Adult; Axons; Brain; Demyelinating Diseases; Electromagnetic Phenomena; Female; Humans; Male; Melato

1995
Pineal opioid receptors and analgesic action of melatonin.
    Journal of pineal research, 1998, Volume: 24, Issue:4

    Topics: Analgesia; Animals; Antioxidants; Circadian Rhythm; Free Radical Scavengers; Humans; Melatonin; Oxid

1998
[Antioxidant effects of melatonin].
    Casopis lekaru ceskych, 2001, Volume: 140, Issue:9

    Topics: Analgesics; Antioxidants; Humans; Melatonin; Oxidative Stress; Pain

2001
Pineal melatonin and sensory symptoms in Parkinson disease.
    Italian journal of neurological sciences, 1989, Volume: 10, Issue:4

    Topics: Animals; Humans; Melatonin; Neurons, Afferent; Pain; Parkinson Disease; Pineal Gland; Serotonin

1989

Trials

15 trials available for melatonin and Ache

ArticleYear
Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial.
    Acta anaesthesiologica Scandinavica, 2022, Volume: 66, Issue:9

    Topics: Analgesics; Anti-Anxiety Agents; Anxiety; Herniorrhaphy; Humans; Melatonin; Pain

2022
The Effect of Melatonin on Analgesia, Anxiety, and Intraocular Pressure (IOP) in Cataract Surgery Under Topical Anesthesia.
    Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses, 2023, Volume: 38, Issue:2

    Topics: Analgesia; Anesthesia, Local; Anxiety; Cataract; Double-Blind Method; Humans; Intraocular Pressure;

2023
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
    Injury, 2022, Volume: 53, Issue:12

    Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa

2022
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
    Injury, 2022, Volume: 53, Issue:12

    Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa

2022
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
    Injury, 2022, Volume: 53, Issue:12

    Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa

2022
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
    Injury, 2022, Volume: 53, Issue:12

    Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa

2022
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
    Injury, 2022, Volume: 53, Issue:12

    Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa

2022
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
    Injury, 2022, Volume: 53, Issue:12

    Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa

2022
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
    Injury, 2022, Volume: 53, Issue:12

    Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa

2022
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
    Injury, 2022, Volume: 53, Issue:12

    Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa

2022
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
    Injury, 2022, Volume: 53, Issue:12

    Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa

2022
Comparison between oral melatonin and 24% sucrose for pain management during retinopathy of prematurity screening: a randomized controlled trial.
    The Turkish journal of pediatrics, 2022, Volume: 64, Issue:6

    Topics: Birth Weight; Humans; Infant; Infant, Newborn; Melatonin; Pain; Pain Management; Pain Measurement; P

2022
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
    Science & sports, 2023, Apr-04

    Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp

2023
Both melatonin and meloxicam improved sleep and pain in females with primary dysmenorrhea-results from a double-blind cross-over intervention pilot study.
    Archives of women's mental health, 2018, Volume: 21, Issue:6

    Topics: Adult; Antioxidants; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Dysmenorr

2018
The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia.
    Indian journal of ophthalmology, 2013, Volume: 61, Issue:7

    Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anxiety; Central Nerv

2013
Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial.
    BMC pharmacology & toxicology, 2014, Jul-23, Volume: 15

    Topics: Adolescent; Adult; Amitriptyline; Analgesics; Brain-Derived Neurotrophic Factor; Double-Blind Method

2014
Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain.
    Neuroimmunomodulation, 2015, Volume: 22, Issue:6

    Topics: Analysis of Variance; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Central Nervous Syst

2015
A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Administration, Sublingual; Adult; Analgesics; Anxiety; Brazil; Depression; Dose-Response Relationsh

2013
Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study.
    Pain, 2015, Volume: 156, Issue:11

    Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Cross-Over Studies; Dose-Response Relatio

2015
Melatonin improves tourniquet tolerance and enhances postoperative analgesia in patients receiving intravenous regional anesthesia.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:4

    Topics: Adjuvants, Anesthesia; Adult; Anesthetics, Local; Anti-Anxiety Agents; Double-Blind Method; Female;

2008
Pain in neonatal intensive care: role of melatonin as an analgesic antioxidant.
    Journal of pineal research, 2012, Volume: 52, Issue:3

    Topics: Analgesics; Antioxidants; Humans; Infant, Newborn; Intensive Care, Neonatal; Melatonin; Pain; Prospe

2012
Analgesic and sedative effects of melatonin in temporomandibular disorders: a double-blind, randomized, parallel-group, placebo-controlled study.
    Journal of pain and symptom management, 2013, Volume: 46, Issue:3

    Topics: Adult; Analgesics, Non-Narcotic; Central Nervous System Depressants; Double-Blind Method; Female; Hu

2013
The effect of melatonin in patients with fibromyalgia: a pilot study.
    Clinical rheumatology, 2000, Volume: 19, Issue:1

    Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Fatigue Syndrome, Chronic; Female; Fibromyalgia;

2000

Other Studies

45 other studies available for melatonin and Ache

ArticleYear
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal;

2008
Killing pain?: a population-based registry study of the use of prescription analgesics, anxiolytics, and hypnotics among all children, adolescents and young adults in Norway from 2004 to 2019.
    European child & adolescent psychiatry, 2023, Volume: 32, Issue:11

    Topics: Adolescent; Adult; Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Child; Child, Preschool; Dru

2023
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage.
    Molecular pain, 2022, Volume: 18

    Topics: Animals; Comorbidity; Disease Models, Animal; Hemorrhage; Humans; Melatonin; Pain; Sleep

2022
The antinociceptive mechanisms of melatonin: role of L-arginine/nitric oxide/cyclic GMP/KATP channel signaling pathway.
    Behavioural pharmacology, 2020, Volume: 31, Issue:8

    Topics: Analgesics; Animals; Animals, Outbred Strains; Arginine; Cyclic GMP; KATP Channels; Male; Melatonin;

2020
Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats.
    Brain research bulletin, 2017, Volume: 135

    Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Drug Tolerance; Hyperalgesia; Male;

2017
Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia.
    Biological research for nursing, 2019, Volume: 21, Issue:1

    Topics: Adult; Analgesics; Female; Fibromyalgia; Humans; Hydrocortisone; Male; Melatonin; Middle Aged; Mood

2019
Melatonin treatment entrains the rest-activity circadian rhythm in rats with chronic inflammation.
    Chronobiology international, 2013, Volume: 30, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Circadian Rhythm; Dexamethasone; Freund's Adjuvant; H

2013
Perioperative melatonin: not ready for prime time.
    British journal of anaesthesia, 2014, Volume: 112, Issue:1

    Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep

2014
Perioperative melatonin: not ready for prime time.
    British journal of anaesthesia, 2014, Volume: 112, Issue:1

    Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep

2014
Perioperative melatonin: not ready for prime time.
    British journal of anaesthesia, 2014, Volume: 112, Issue:1

    Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep

2014
Perioperative melatonin: not ready for prime time.
    British journal of anaesthesia, 2014, Volume: 112, Issue:1

    Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep

2014
Perioperative melatonin: not ready for prime time.
    British journal of anaesthesia, 2014, Volume: 112, Issue:1

    Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep

2014
Perioperative melatonin: not ready for prime time.
    British journal of anaesthesia, 2014, Volume: 112, Issue:1

    Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep

2014
Perioperative melatonin: not ready for prime time.
    British journal of anaesthesia, 2014, Volume: 112, Issue:1

    Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep

2014
Perioperative melatonin: not ready for prime time.
    British journal of anaesthesia, 2014, Volume: 112, Issue:1

    Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep

2014
Perioperative melatonin: not ready for prime time.
    British journal of anaesthesia, 2014, Volume: 112, Issue:1

    Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep

2014
Anti-inflammatory activities of melatonin derivatives in lipopolysaccharide-stimulated RAW 264.7 cells and antinociceptive effects in mice.
    Drug development research, 2014, Volume: 75, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Dose-Response Rela

2014
Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.
    Cell reports, 2014, Sep-11, Volume: 8, Issue:5

    Topics: Actins; Adaptation, Physiological; Amino Acid Sequence; Animals; Ecosystem; Genetic Speciation; Geno

2014
Behavioral Indexes of Thermal Nociceptive Sensitivity in Rats after Melatonin Administration.
    Bulletin of experimental biology and medicine, 2015, Volume: 160, Issue:2

    Topics: Animals; Male; Melatonin; Nociception; Pain; Rats; Rats, Wistar

2015
Potential positive feedback loop of pineal cyst and posttraumatic stress disorder.
    Medical hypotheses, 2017, Volume: 100

    Topics: Adult; Brain Neoplasms; Cysts; Female; Homeostasis; Humans; Incidental Findings; Magnetic Resonance

2017
Possible participation of the nitric oxide-cyclic GMP-protein kinase G-K+ channels pathway in the peripheral antinociception of melatonin.
    European journal of pharmacology, 2008, Oct-31, Volume: 596, Issue:1-3

    Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Female; Melatonin; Nitric Oxide; Pain; Pa

2008
Is there a role of melatonin in the development of growing pains?
    Medical hypotheses, 2009, Volume: 72, Issue:2

    Topics: Age Factors; Child; Child, Preschool; Growth and Development; Humans; Leg; Melatonin; Pain

2009
Evaluation for the interaction between intrathecal melatonin and clonidine or neostigmine on formalin-induced nociception.
    Life sciences, 2008, Dec-19, Volume: 83, Issue:25-26

    Topics: Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Drug

2008
[Chronopharmacology: exact timing of drug dose improves the treatment outcome].
    Deutsche medizinische Wochenschrift (1946), 2009, Volume: 134, Issue:20

    Topics: Arthritis, Rheumatoid; Asthma; Cardiovascular Physiological Phenomena; Circadian Rhythm; Digestive S

2009
Preliminary analgesic properties of deltorphin-5-methoxytryptamine chimeric opioid peptides.
    Peptides, 2011, Volume: 32, Issue:5

    Topics: 5-Methoxytryptamine; Analgesics; Animals; Male; Melatonin; Mice; Oligopeptides; Opioid Peptides; Pai

2011
Receptors involved in the antinociception of intrathecal melatonin in formalin test of rats.
    Neuroscience letters, 2011, May-02, Volume: 494, Issue:3

    Topics: Animals; Central Nervous System Depressants; Formaldehyde; Injections, Spinal; Irritants; Male; Mela

2011
Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia.
    World journal of gastroenterology, 2011, Jun-07, Volume: 17, Issue:21

    Topics: Adult; Circadian Rhythm; Diagnosis, Differential; Dyspepsia; Female; Humans; Male; Melatonin; Middle

2011
[Sleep disorder and pain: the good hypnotic].
    Revue medicale suisse, 2011, Jun-29, Volume: 7, Issue:301

    Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anticonvulsants; Behavior Therapy

2011
Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat.
    Pharmacological research, 2002, Volume: 46, Issue:3

    Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal;

2002
The presence of delta and mu-, but not kappa or ORL(1) receptors in bovine pinealocytes.
    Brain research, 2002, Sep-27, Volume: 951, Issue:1

    Topics: Animals; Binding, Competitive; Cattle; Cell Membrane; Circadian Rhythm; Female; Melatonin; Narcotic

2002
Gene expression and functional characterization of melatonin receptors in the spinal cord of the rat: implications for pain modulation.
    Journal of pineal research, 2003, Volume: 35, Issue:1

    Topics: Animals; Melatonin; Oocytes; Pain; Polymerase Chain Reaction; Rats; Receptors, Melatonin; RNA, Messe

2003
Evaluation of the role of melatonin in formalin-induced pain response in mice.
    Indian journal of medical sciences, 2004, Volume: 58, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Melatonin; Mice; Pain; Receptors, Adr

2004
Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Administration, Topical; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Drug Interac

2004
Diurnal changes of tonic nociceptive responses in mice: evidence for a proalgesic role of melatonin.
    Pain, 2004, Volume: 110, Issue:1-2

    Topics: Animals; Autoradiography; Behavior, Animal; Binding Sites; Circadian Rhythm; Formaldehyde; Grooming;

2004
Direct measurement of free radicals in the brain cortex and the blood serum after nociceptive stimulation in rats.
    Neuro endocrinology letters, 2004, Volume: 25, Issue:4

    Topics: Analysis of Variance; Animals; Free Radicals; Hydroxyl Radical; Male; Melatonin; Nitrogen Oxides; Pa

2004
Intrathecal melatonin increases the mechanical nociceptive threshold in the rat.
    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2004, Volume: 16, Issue:4

    Topics: Animals; Drug Administration Schedule; Injections, Spinal; Male; Melatonin; Pain; Pain Measurement;

2004
Mechanisms involved in the antinociception caused by melatonin in mice.
    Journal of pineal research, 2006, Volume: 41, Issue:4

    Topics: Adrenalectomy; Analgesics; Animals; Capsaicin; Male; Melatonin; Mice; Pain

2006
Melatonin inhibits cortical spreading depression-evoked trigeminal nociception.
    Neuroreport, 2006, Nov-06, Volume: 17, Issue:16

    Topics: Animals; Cerebral Cortex; Cortical Spreading Depression; Endothelial Cells; Immunohistochemistry; Ma

2006
Oral and spinal melatonin reduces tactile allodynia in rats via activation of MT2 and opioid receptors.
    Pain, 2007, Dec-05, Volume: 132, Issue:3

    Topics: Administration, Oral; Animals; Female; Injections, Spinal; Melatonin; Pain; Physical Stimulation; Ra

2007
Melatonin reduces formalin-induced nociception and tactile allodynia in diabetic rats.
    European journal of pharmacology, 2007, Dec-22, Volume: 577, Issue:1-3

    Topics: Analgesics; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Female; Formaldehyde; Guanid

2007
Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache.
    Cephalalgia : an international journal of headache, 1995, Volume: 15, Issue:3

    Topics: Adult; Analysis of Variance; Circadian Rhythm; Cluster Headache; Female; Humans; Hydrocortisone; Mal

1995
Melatonin and painful gynecomastia.
    Neurology, 1999, Jul-22, Volume: 53, Issue:2

    Topics: Amyotrophic Lateral Sclerosis; Gynecomastia; Humans; Male; Melatonin; Middle Aged; Pain; Pain Manage

1999
The analgesic effects of peripheral and central administration of melatonin in rats.
    European journal of pharmacology, 2000, Sep-01, Volume: 403, Issue:1-2

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intr

2000
Circadian rhythms of women with fibromyalgia.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:3

    Topics: Adult; Body Temperature; Circadian Rhythm; Female; Fibromyalgia; Food; Humans; Hydrocortisone; Light

2001
Pain modulation role of melatonin in eating disorders.
    European psychiatry : the journal of the Association of European Psychiatrists, 2001, Volume: 16, Issue:1

    Topics: Adult; Anorexia Nervosa; Bulimia; Enzyme-Linked Immunosorbent Assay; Female; Hospitalization; Humans

2001
Salivary melatonin response to acute pain stimuli.
    Journal of pineal research, 2001, Volume: 30, Issue:4

    Topics: Acute Disease; Adult; Analgesia; Circadian Rhythm; Electroshock; Female; Humans; Male; Melatonin; Mi

2001
Alteration of orphanin FQ immunoreactivity and ppOFQ mRNA by combination of melatonin with electroacupuncture.
    Acupuncture & electro-therapeutics research, 2001, Volume: 26, Issue:1-2

    Topics: Acupuncture Analgesia; Analgesics, Opioid; Animals; Brain Chemistry; Dose-Response Relationship, Dru

2001
Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat?
    Physiological research, 2001, Volume: 50, Issue:6

    Topics: Animals; Free Radical Scavengers; Free Radicals; Hyperalgesia; Male; Melatonin; Oxidative Stress; Pa

2001
[Effects of the pineal body and melatonin on sensitivity to pain in mice].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:5

    Topics: Animals; Circadian Rhythm; Female; Melatonin; Meperidine; Mice; Morphine; Pain; Pineal Gland; Sensor

1990
Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin.
    European archives of psychiatry and neurological sciences, 1986, Volume: 236, Issue:3

    Topics: Adult; Chronic Disease; Depressive Disorder; Female; Homovanillic Acid; Humans; Hydrocortisone; Hydr

1986
Circadian rhythms in patients with abdominal pain syndromes.
    Australian and New Zealand journal of medicine, 1988, Volume: 18, Issue:4

    Topics: Abdomen; Biliary Tract Diseases; Body Temperature Regulation; Cholecystectomy; Circadian Rhythm; Col

1988
Melatonin in serum and urine in patients with idiopathic pain syndromes.
    Psychiatry research, 1987, Volume: 22, Issue:3

    Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Ne

1987
Effect of neurotropin on hyperalgesia induced by prostaglandin E2, naloxone, melatonin and dark condition in mice.
    Japanese journal of pharmacology, 1987, Volume: 43, Issue:4

    Topics: Analgesics; Animals; Aspirin; Darkness; Dinoprostone; Formaldehyde; Male; Melatonin; Mice; Naloxone;

1987