melatonin has been researched along with Ache in 84 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the effect of oral melatonin as a premedication before cataract surgery on pain score, anxiety, surgical conditions, and intraocular pressure (IOP) during cataract surgery with phacoemulsification under topical anesthesia." | 9.69 | The Effect of Melatonin on Analgesia, Anxiety, and Intraocular Pressure (IOP) in Cataract Surgery Under Topical Anesthesia. ( Abdelbasset, WK; Golabi, P; Haki, BK; Komilzhonovich, IN; Mahmodi, H; Morwati, S; Motarjemizadeh, Q; Rahmani, N; Sane, S; Suksatan, W; Zaman, GS, 2023) |
| "Melatonin did not reduce preoperative anxiety in patients undergoing hernia repair." | 9.51 | Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial. ( Gram-Hanssen, A; Holm, MA; Madsen, BK; Rosenberg, J; Zetner, DB, 2022) |
| " All preterm neonates with gestational age (GA) < 34 weeks or birth weight (BW) < 2000 grams eligible for ROP screening were randomized into oral melatonin (4 mg/kg) and oral 24% sucrose (0." | 9.51 | Comparison between oral melatonin and 24% sucrose for pain management during retinopathy of prematurity screening: a randomized controlled trial. ( Behura, SS; Dhanawat, A; Nayak, B; Panda, SK, 2022) |
| " In experiment 1, all animals were injected with complete Freund's adjuvant (CFA) to induce inflammation and were randomly allocated to receiving melatonin (60 mg/kg) or vehicle." | 9.20 | Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain. ( Caumo, W; Laste, G; Lucena da Silva Torres, I; Ripoll Rozisky, J, 2015) |
| "Melatonin alone or in combination with amitriptyline reduced significantly pain on the VAS compared with amitriptyline alone (P < 0." | 9.19 | Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. ( Caumo, W; de Souza, IC; de Zanette, SA; Deitos, A; Laste, G; Machado, CB; Rozisky, JR; Schwertner, A; Torres, IL; Vercelino, R; Xavier, F, 2014) |
| "The objective was to evaluate the analgesic dose response of the effects of melatonin on pressure and heat pain threshold and tolerance and the sedative effects." | 9.17 | A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects. ( Caumo, W; Fregni, F; Markus, R; Muller, S; Razzolini, B; Rozisky, JR; Stefani, LC; Torres, IL, 2013) |
| "Melatonin significantly reduced the anxiety scores (median, interquartile range) from 5 and 5-3 to 3 and 2-4 after premedication and to 3 and 2-3 during surgery and to 0 and 0-1 postoperatively before discharge from the recovery room." | 9.17 | The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia. ( Khezri, MB; Merate, H, 2013) |
| "The aim of the study was to determine the possible effect of melatonin treatment on disturbed sleep, fatigue and pain symptoms observed in fibromyalgia (FM) patients." | 9.09 | The effect of melatonin in patients with fibromyalgia: a pilot study. ( Arias, MA; Brusco, LI; Cardinalli, DP; Citera, G; Lázaro, MA; Maldonado-Cocco, JA; Rosemffet, MG; Scheines, EJ, 2000) |
| "The antinociceptive effect of melatonin has been evaluated in diverse pain models, and several findings show that melatonin receptors modulate pain mechanisms as activation induces an antinociceptive effect at spinal and supraspinal levels under conditions of acute and inflammatory pain." | 8.85 | Melatonin: a hormone that modulates pain. ( Ambriz-Tututi, M; Cruz, SL; Granados-Soto, V; Rocha-González, HI, 2009) |
| "Melatonin improved mood, anxiety levels, and quality of life while decreasing cortisol levels in patients with fibromyalgia." | 7.91 | Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia. ( Castaño, MY; Garrido, M; Gómez, MÁ; Rodríguez, AB, 2019) |
| "We assessed the therapeutic effect of exogenous melatonin (MEL), dexamethasone (DEXA), and a combination of both on nociceptive response induced by chronic inflammation and on the rest-activity circadian rhythm in rats." | 7.79 | Melatonin treatment entrains the rest-activity circadian rhythm in rats with chronic inflammation. ( Caumo, W; de Macedo, IC; de Souza, A; de Souza, IC; Laste, G; Medeiros, L; Meurer, L; Rozisky, JR; Torres, IL; Vidor, L, 2013) |
| "To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin (6-OHMS), in functional dyspepsia (FD)." | 7.77 | Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia. ( Blasiak, J; Chojnacki, C; Chojnacki, J; Klupinska, G; Poplawski, T; Reiter, RJ, 2011) |
| "Effect of melatonin (25-100 mg/kg, ip) and its interaction with putative melatonin receptor antagonists and opioidergic and serotoninergic agents have been studied in formalin test, a model of tonic continuous pain." | 7.72 | Evaluation of the role of melatonin in formalin-induced pain response in mice. ( Mahajan, P; Mediratta, PK; Ray, M; Sharma, KK, 2004) |
| "The objective of this study was to test the effect of melatonin on thermal pain threshold in female patients with eating disorders." | 7.71 | Pain modulation role of melatonin in eating disorders. ( Nedvídková, J; Papezová, H; Yamamotová, A, 2001) |
| "The cyclic recurrence of cluster periods and the regular timing of headache occurrence in cluster headache (CH) induced us to study the circadian secretion of melatonin and cortisol in 12 patients with episodic CH, during a cluster period, and compare them with 7 age- and sex-matched healthy controls." | 7.69 | Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache. ( Bussone, G; D'Amico, D; Fraschini, F; Leone, M; Lucini, V; Maltempo, C; Moschiano, F, 1995) |
| "The aim of the present study was to investigate the discriminative power of a series of variables (including determination of depressive symptomatology by means of a visual analogue scale, determination of personality traits by means of the Karolinska Scales of Personality, determination of monoamine metabolites in CSF, platelet MAO activities, serum cortisol before and after dexamethasone suppression and urinary melatonin) in differentiating chronic pain patients from healthy subjects, and patients with idiopathic pain syndromes from patients with neurogenic pain syndromes." | 7.67 | Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin. ( Almay, BG; Häggendal, J; Johansson, F; Oreland, L; von Knorring, L; Wetterberg, L, 1986) |
| "In 16 healthy volunteers, 16 patients with neurogenic pain syndromes, 37 patients with idiopathic pain syndromes, and 30 depressed patients, melatonin in serum was determined at 2 a." | 7.67 | Melatonin in serum and urine in patients with idiopathic pain syndromes. ( Almay, BG; von Knorring, L; Wetterberg, L, 1987) |
| "Melatonin is a neurohormone secreted by the pineal gland with antioxidant and anti-inflammatory functions." | 6.82 | Potential benefits of melatonin to control pain in ventilated preterm newborns: An updated review. ( Cannavò, L; Di Rosa, G; Gitto, E; Marseglia, L; Perrone, S; Viola, V, 2022) |
| "Pain during the BI and secondary hyperalgesia areas were defined as primary outcomes." | 6.80 | Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study. ( Andersen, LPH; Fenger, AQ; Gögenur, I; Petersen, MC; Rosenberg, J; Werner, MU, 2015) |
| "Endotracheal intubation is a common painful procedure in newborn care." | 6.77 | Pain in neonatal intensive care: role of melatonin as an analgesic antioxidant. ( Arrigo, T; Aversa, S; Barberi, I; Gitto, E; Pellegrino, S; Reiter, RJ; Salpietro, CD; Trimarchi, G, 2012) |
| "Melatonin is a well-known jet-lag compound, which helps in entrainment of sleep cycle." | 5.72 | Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage. ( Huang, ACW; Kaur, T; Shih, HC; Shyu, BC, 2022) |
| "This study investigated the effect of oral melatonin as a premedication before cataract surgery on pain score, anxiety, surgical conditions, and intraocular pressure (IOP) during cataract surgery with phacoemulsification under topical anesthesia." | 5.69 | The Effect of Melatonin on Analgesia, Anxiety, and Intraocular Pressure (IOP) in Cataract Surgery Under Topical Anesthesia. ( Abdelbasset, WK; Golabi, P; Haki, BK; Komilzhonovich, IN; Mahmodi, H; Morwati, S; Motarjemizadeh, Q; Rahmani, N; Sane, S; Suksatan, W; Zaman, GS, 2023) |
| "Melatonin did not reduce preoperative anxiety in patients undergoing hernia repair." | 5.51 | Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial. ( Gram-Hanssen, A; Holm, MA; Madsen, BK; Rosenberg, J; Zetner, DB, 2022) |
| "Explore sleep disturbance in postoperative orthopedic trauma patients and determine the impact of melatonin supplementation on postoperative sleep, pain, and quality of life." | 5.51 | Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial. ( Bishop, J; Calderon, C; Fithian, A; Gardner, M; Schultz, B; Segovia, N; Tanner, N, 2022) |
| " All preterm neonates with gestational age (GA) < 34 weeks or birth weight (BW) < 2000 grams eligible for ROP screening were randomized into oral melatonin (4 mg/kg) and oral 24% sucrose (0." | 5.51 | Comparison between oral melatonin and 24% sucrose for pain management during retinopathy of prematurity screening: a randomized controlled trial. ( Behura, SS; Dhanawat, A; Nayak, B; Panda, SK, 2022) |
| "Melatonin responses were abolished by simultaneous administration of the antagonists, 2-phenylmelatonin and luzindole and were unaffected by the MT2 antagonist 4-phenyl-2-propionamidotetralin." | 5.32 | Gene expression and functional characterization of melatonin receptors in the spinal cord of the rat: implications for pain modulation. ( Berger, E; Lansmann, T; Musshoff, U; Speckmann, EJ; Zahn, PK, 2003) |
| "Melatonin has been shown to play a role in antioxidative defence." | 5.31 | Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat? ( Holecek, V; Parara, S; Pekárková, I; Racek, J; Rokyta, R; Stopka, P; Trefil, L, 2001) |
| " In experiment 1, all animals were injected with complete Freund's adjuvant (CFA) to induce inflammation and were randomly allocated to receiving melatonin (60 mg/kg) or vehicle." | 5.20 | Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain. ( Caumo, W; Laste, G; Lucena da Silva Torres, I; Ripoll Rozisky, J, 2015) |
| "Melatonin alone or in combination with amitriptyline reduced significantly pain on the VAS compared with amitriptyline alone (P < 0." | 5.19 | Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. ( Caumo, W; de Souza, IC; de Zanette, SA; Deitos, A; Laste, G; Machado, CB; Rozisky, JR; Schwertner, A; Torres, IL; Vercelino, R; Xavier, F, 2014) |
| "Melatonin significantly reduced the anxiety scores (median, interquartile range) from 5 and 5-3 to 3 and 2-4 after premedication and to 3 and 2-3 during surgery and to 0 and 0-1 postoperatively before discharge from the recovery room." | 5.17 | The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia. ( Khezri, MB; Merate, H, 2013) |
| "This study provides additional evidence supporting the analgesic effects of melatonin on pain scores and analgesic consumption in patients with mild-to-moderate chronic myofascial TMD pain." | 5.17 | Analgesic and sedative effects of melatonin in temporomandibular disorders: a double-blind, randomized, parallel-group, placebo-controlled study. ( Caumo, W; Custódio de Souza, IC; Fregni, F; Torres, IL; Vidor, LP, 2013) |
| "The objective was to evaluate the analgesic dose response of the effects of melatonin on pressure and heat pain threshold and tolerance and the sedative effects." | 5.17 | A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects. ( Caumo, W; Fregni, F; Markus, R; Muller, S; Razzolini, B; Rozisky, JR; Stefani, LC; Torres, IL, 2013) |
| "Melatonin is an effective premedication before IVRA since it reduced patient anxiety, decreased tourniquet-related pain, and improved perioperative analgesia." | 5.13 | Melatonin improves tourniquet tolerance and enhances postoperative analgesia in patients receiving intravenous regional anesthesia. ( Ismail, SA; Mowafi, HA, 2008) |
| "The aim of the study was to determine the possible effect of melatonin treatment on disturbed sleep, fatigue and pain symptoms observed in fibromyalgia (FM) patients." | 5.09 | The effect of melatonin in patients with fibromyalgia: a pilot study. ( Arias, MA; Brusco, LI; Cardinalli, DP; Citera, G; Lázaro, MA; Maldonado-Cocco, JA; Rosemffet, MG; Scheines, EJ, 2000) |
| "Melatonin, the main hormone of the pineal gland, possesses analgesic properties, which were observed on various experimental models of pain and in the clinical practice." | 4.88 | [Analgesic properties of pineal hormone melatonin]. ( Arushanian, ÉB, 2012) |
| "The antinociceptive effect of melatonin has been evaluated in diverse pain models, and several findings show that melatonin receptors modulate pain mechanisms as activation induces an antinociceptive effect at spinal and supraspinal levels under conditions of acute and inflammatory pain." | 4.85 | Melatonin: a hormone that modulates pain. ( Ambriz-Tututi, M; Cruz, SL; Granados-Soto, V; Rocha-González, HI, 2009) |
| "Age, APACHE score at ICU admission, neurological disease, sepsis and duration of mechanical ventilation were all independent risk factors for the development of delirium in ICU patients." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "Melatonin improved mood, anxiety levels, and quality of life while decreasing cortisol levels in patients with fibromyalgia." | 3.91 | Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia. ( Castaño, MY; Garrido, M; Gómez, MÁ; Rodríguez, AB, 2019) |
| "Morphine is a widely used analgesic for various types of pain." | 3.85 | Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats. ( Fan, Y; Liang, X; Song, L; Wang, R, 2017) |
| "We assessed the therapeutic effect of exogenous melatonin (MEL), dexamethasone (DEXA), and a combination of both on nociceptive response induced by chronic inflammation and on the rest-activity circadian rhythm in rats." | 3.79 | Melatonin treatment entrains the rest-activity circadian rhythm in rats with chronic inflammation. ( Caumo, W; de Macedo, IC; de Souza, A; de Souza, IC; Laste, G; Medeiros, L; Meurer, L; Rozisky, JR; Torres, IL; Vidor, L, 2013) |
| "To further understand the relationship between melatonin (MT) and deltorphins (Dels) in pain modulation, two chimeric peptides (Del I-5-methoxytryptamine and Del II-5-methoxytryptamine) both containing 5-methoxytryptamine at the carboxyl-terminal of Dels mimicking MT were designed, synthesized and characterized by tail-flick assay in mice." | 3.77 | Preliminary analgesic properties of deltorphin-5-methoxytryptamine chimeric opioid peptides. ( Dong, S; Jin, Q; Li, M; Wang, J; Wang, L, 2011) |
| "To evaluate blood concentration of melatonin and urinary excretion of its metabolite, 6-sulfatoxymelatonin (6-OHMS), in functional dyspepsia (FD)." | 3.77 | Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia. ( Blasiak, J; Chojnacki, C; Chojnacki, J; Klupinska, G; Poplawski, T; Reiter, RJ, 2011) |
| "Effect of melatonin (25-100 mg/kg, ip) and its interaction with putative melatonin receptor antagonists and opioidergic and serotoninergic agents have been studied in formalin test, a model of tonic continuous pain." | 3.72 | Evaluation of the role of melatonin in formalin-induced pain response in mice. ( Mahajan, P; Mediratta, PK; Ray, M; Sharma, KK, 2004) |
| "The objective of this study was to test the effect of melatonin on thermal pain threshold in female patients with eating disorders." | 3.71 | Pain modulation role of melatonin in eating disorders. ( Nedvídková, J; Papezová, H; Yamamotová, A, 2001) |
| "The cyclic recurrence of cluster periods and the regular timing of headache occurrence in cluster headache (CH) induced us to study the circadian secretion of melatonin and cortisol in 12 patients with episodic CH, during a cluster period, and compare them with 7 age- and sex-matched healthy controls." | 3.69 | Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache. ( Bussone, G; D'Amico, D; Fraschini, F; Leone, M; Lucini, V; Maltempo, C; Moschiano, F, 1995) |
| "Subcutaneous injection of formaldehyde into mouse hind paw elicited pain responses consisting of licking or biting of the paw, which were observed biphasically." | 3.67 | Effect of neurotropin on hyperalgesia induced by prostaglandin E2, naloxone, melatonin and dark condition in mice. ( Inoki, R; Ohkubo, T; Saito, K; Shibata, M; Takahashi, H, 1987) |
| "Circadian rhythms for cortisol, 6-sulphatoxy melatonin and core body temperature were compared in control subjects and patients with functional abdominal pain." | 3.67 | Circadian rhythms in patients with abdominal pain syndromes. ( Kennaway, DJ; Knight, RE; Pannall, PR; Roberts-Thomson, IC, 1988) |
| "In 16 healthy volunteers, 16 patients with neurogenic pain syndromes, 37 patients with idiopathic pain syndromes, and 30 depressed patients, melatonin in serum was determined at 2 a." | 3.67 | Melatonin in serum and urine in patients with idiopathic pain syndromes. ( Almay, BG; von Knorring, L; Wetterberg, L, 1987) |
| "The aim of the present study was to investigate the discriminative power of a series of variables (including determination of depressive symptomatology by means of a visual analogue scale, determination of personality traits by means of the Karolinska Scales of Personality, determination of monoamine metabolites in CSF, platelet MAO activities, serum cortisol before and after dexamethasone suppression and urinary melatonin) in differentiating chronic pain patients from healthy subjects, and patients with idiopathic pain syndromes from patients with neurogenic pain syndromes." | 3.67 | Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin. ( Almay, BG; Häggendal, J; Johansson, F; Oreland, L; von Knorring, L; Wetterberg, L, 1986) |
| "Different treatments, durations and cancer types were the main sources of heterogeneity." | 2.82 | Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials. ( Bu, X; Chen, H; Fan, R; Li, X; Tan, Y; Wang, T; Yang, S, 2022) |
| "Melatonin is a neurohormone secreted by the pineal gland with antioxidant and anti-inflammatory functions." | 2.82 | Potential benefits of melatonin to control pain in ventilated preterm newborns: An updated review. ( Cannavò, L; Di Rosa, G; Gitto, E; Marseglia, L; Perrone, S; Viola, V, 2022) |
| "Pain during the BI and secondary hyperalgesia areas were defined as primary outcomes." | 2.80 | Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study. ( Andersen, LPH; Fenger, AQ; Gögenur, I; Petersen, MC; Rosenberg, J; Werner, MU, 2015) |
| "Endotracheal intubation is a common painful procedure in newborn care." | 2.77 | Pain in neonatal intensive care: role of melatonin as an analgesic antioxidant. ( Arrigo, T; Aversa, S; Barberi, I; Gitto, E; Pellegrino, S; Reiter, RJ; Salpietro, CD; Trimarchi, G, 2012) |
| "Age, gender, and co-morbidities such as migraine seem to influence the prevalence of PSH." | 2.61 | Primary Stabbing Headache. ( Dilli, E; Murray, D, 2019) |
| "Pain is a multidimensional response involving several levels of expression ranging from somatosensory to emotional." | 2.50 | Restless legs syndrome and pain disorders: what's in common? ( Delgado Rodrigues, RN; Goulart, LI; Prieto Peres, MF, 2014) |
| "Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties." | 2.47 | Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies. ( Amirian, I; Gögenur, I; Reiter, RJ; Rosenberg, J; Wilhelmsen, M, 2011) |
| " Additional well designed randomized controlled trials are necessary to compare melatonin premedication with other pharmacological interventions, investigate its effect on more varied surgical populations, and to delineate its optimal dosing regimen." | 2.46 | Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials. ( Abrishami, A; Chung, F; Seet, E; Venkatraghavan, L; Yousaf, F, 2010) |
| "Melatonin is a remarkable molecule with diverse physiological functions." | 2.46 | Potential use of melatonergic drugs in analgesia: mechanisms of action. ( Brown, GM; Cardinali, DP; Moscovitch, A; Pandi-Perumal, SR; Spence, DW; Srinivasan, V; Trakht, I, 2010) |
| "Melatonin is a widely distributed and important signal molecule that occurs in unicellular organisms, plants, and fungi in addition to animals and humans." | 2.45 | Chapter 16: Melatonin and nerve regeneration. ( Kaplan, S; Odaci, E, 2009) |
| "How melatonin affects cancer remains largely unclear." | 2.44 | Neurobiological effects of melatonin as related to cancer. ( Hoang, BX; Levine, SA; Pham, PT; Shaw, DG, 2007) |
| "Pain is a multi-dimensional process involving the physical, emotional and perceptual integration of noxious information." | 2.42 | Pain in the brain: are hormones to blame? ( Blackburn-Munro, G; Blackburn-Munro, R, 2003) |
| "Melatonin is a well-known jet-lag compound, which helps in entrainment of sleep cycle." | 1.72 | Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage. ( Huang, ACW; Kaur, T; Shih, HC; Shyu, BC, 2022) |
| "Pain is one of the most common medical challenges, reducing life quality." | 1.56 | The antinociceptive mechanisms of melatonin: role of L-arginine/nitric oxide/cyclic GMP/KATP channel signaling pathway. ( Abbaszadeh, F; Ahmadpour, Y; Fakhri, S; Ghanbarveisi, F; Gravandi, MM; Iranpanah, A; Kooshki, L; Moradi, SZ; Rezaei, H, 2020) |
| "Pain was assessed using the formalin test (induced by a subcutaneous injection of 50 microl of a 5% formalin solution to the hindpaw)." | 1.35 | Evaluation for the interaction between intrathecal melatonin and clonidine or neostigmine on formalin-induced nociception. ( Huang, LJ; Kim, WM; Kim, YO; Lee, HG; Park, HC; Yoon, MH, 2008) |
| "Pretreatment with melatonin also reduced the number of Fos and nitric oxide synthase immunoreactive cells in the trigeminal nucleus caudalis." | 1.33 | Melatonin inhibits cortical spreading depression-evoked trigeminal nociception. ( le Grand, SM; Patumraj, S; Phansuwan-Pujito, P; Srikiatkhachorn, A, 2006) |
| "Melatonin responses were abolished by simultaneous administration of the antagonists, 2-phenylmelatonin and luzindole and were unaffected by the MT2 antagonist 4-phenyl-2-propionamidotetralin." | 1.32 | Gene expression and functional characterization of melatonin receptors in the spinal cord of the rat: implications for pain modulation. ( Berger, E; Lansmann, T; Musshoff, U; Speckmann, EJ; Zahn, PK, 2003) |
| "Acute inflammation was induced by sub-plantar injection of carrageenan (1%) in the rat hind paw." | 1.31 | Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. ( Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Batran, S; El-Shenawy, SM, 2002) |
| "Melatonin has been shown to play a role in antioxidative defence." | 1.31 | Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat? ( Holecek, V; Parara, S; Pekárková, I; Racek, J; Rokyta, R; Stopka, P; Trefil, L, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (5.95) | 18.7374 |
| 1990's | 5 (5.95) | 18.2507 |
| 2000's | 33 (39.29) | 29.6817 |
| 2010's | 30 (35.71) | 24.3611 |
| 2020's | 11 (13.10) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Stangeland, H | 1 |
| Handal, M | 1 |
| Skurtveit, SO | 1 |
| Aakvaag, HF | 1 |
| Dyb, G | 1 |
| Wentzel-Larsen, T | 1 |
| Baumann-Larsen, M | 1 |
| Zwart, JA | 1 |
| Storheim, K | 1 |
| Stensland, SØ | 1 |
| Kaur, T | 1 |
| Shih, HC | 1 |
| Huang, ACW | 1 |
| Shyu, BC | 1 |
| Fan, R | 1 |
| Bu, X | 1 |
| Yang, S | 1 |
| Tan, Y | 1 |
| Wang, T | 1 |
| Chen, H | 1 |
| Li, X | 1 |
| Holm, MA | 1 |
| Gram-Hanssen, A | 1 |
| Madsen, BK | 1 |
| Zetner, DB | 1 |
| Rosenberg, J | 4 |
| Sane, S | 1 |
| Motarjemizadeh, Q | 1 |
| Komilzhonovich, IN | 1 |
| Abdelbasset, WK | 1 |
| Zaman, GS | 1 |
| Suksatan, W | 1 |
| Morwati, S | 1 |
| Haki, BK | 1 |
| Rahmani, N | 1 |
| Golabi, P | 1 |
| Mahmodi, H | 1 |
| Tanner, N | 3 |
| Schultz, B | 3 |
| Calderon, C | 3 |
| Fithian, A | 3 |
| Segovia, N | 3 |
| Bishop, J | 3 |
| Gardner, M | 3 |
| Behura, SS | 1 |
| Dhanawat, A | 1 |
| Nayak, B | 1 |
| Panda, SK | 1 |
| Hemati, K | 1 |
| Amini Kadijani, A | 1 |
| Sayehmiri, F | 1 |
| Mehrzadi, S | 1 |
| Zabihiyeganeh, M | 1 |
| Hosseinzadeh, A | 1 |
| Mirzaei, A | 1 |
| Fakhri, S | 1 |
| Ahmadpour, Y | 1 |
| Rezaei, H | 1 |
| Kooshki, L | 1 |
| Moradi, SZ | 1 |
| Iranpanah, A | 1 |
| Gravandi, MM | 1 |
| Abbaszadeh, F | 1 |
| Ghanbarveisi, F | 1 |
| Cannavò, L | 1 |
| Perrone, S | 1 |
| Marseglia, L | 2 |
| Viola, V | 1 |
| Di Rosa, G | 1 |
| Gitto, E | 3 |
| Fan, Y | 1 |
| Liang, X | 1 |
| Wang, R | 1 |
| Song, L | 1 |
| Keshavarzi, F | 1 |
| Mahmoudzadeh, F | 1 |
| Brand, S | 1 |
| Sadeghi Bahmani, D | 1 |
| Akbari, F | 1 |
| Khazaie, H | 1 |
| Ghadami, MR | 1 |
| Castaño, MY | 1 |
| Garrido, M | 1 |
| Rodríguez, AB | 1 |
| Gómez, MÁ | 1 |
| Murray, D | 1 |
| Dilli, E | 1 |
| Srinivasan, V | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Killing Pain - Use of Analgesic, Sedative and Anxiolytic Medication and the Development of Psychiatric Illness in Adolescents[NCT04336605] | 25,000 participants (Actual) | Observational [Patient Registry] | 2020-02-01 | Active, not recruiting | |||
| Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure[NCT02415309] | Phase 3 | 25 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy[NCT03115034] | Phase 4 | 60 participants (Actual) | Interventional | 2016-06-01 | Completed | ||
| The Adjunctive Use of Systemic Melatonin Therapy in the Treatment of Periodontitis Associated With Obesity (Clinical and Immunological Study).[NCT04788979] | Phase 1/Phase 2 | 80 participants (Anticipated) | Interventional | 2021-04-01 | Not yet recruiting | ||
| Phase II Role of Immune-pineal Axis in Fibromyalgia: Noradrenergic Modulation and Chronotherapeutic Aspects[NCT02041455] | Phase 2/Phase 3 | 66 participants (Anticipated) | Interventional | 2010-06-30 | Recruiting | ||
| Effects of Oral Melatonin on Neurosensory Recovery Following Facial Osteotomies - A Randomised, Controlled Clinical Trial[NCT02889432] | Phase 2 | 40 participants (Anticipated) | Interventional | 2016-06-30 | Recruiting | ||
| The Therapeutic Effect of Melatonin in Pediatric Patients With Functional Dyspepsia[NCT04684199] | 14 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery[NCT04791943] | Phase 2 | 60 participants (Anticipated) | Interventional | 2021-05-12 | Recruiting | ||
| CHOCOlate MeLatonin for AdolescenT MigrainE: The CHOCOLATE Study[NCT03597529] | Phase 2 | 84 participants (Actual) | Interventional | 2017-09-25 | Completed | ||
| SurgerySMART: Studying Melatonin and Recovery in Teens[NCT06093477] | 40 participants (Anticipated) | Interventional | 2024-07-31 | Not yet recruiting | |||
| The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol in Mechanically Ventilated Traumatic Brain Injury Patient: RCT[NCT04034771] | Phase 3 | 38 participants (Actual) | Interventional | 2018-01-01 | Completed | ||
| The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery: a Prospective Randomised Controlled Cohort Study[NCT02424071] | Phase 4 | 60 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465] | 50 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Visual Analog Scale (VAS) score ranges from 0-10, measured in cm, 0 indicating no pain and 10 indicating the worst pain. (NCT03597529)
Timeframe: Baseline (Time 0) and 2 hours
| Intervention | cm (Mean) |
|---|---|
| Low-Dose Melatonin (mg) | -2.3 |
| High-Dose Melatonin (mg) | -2.7 |
Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery
| Intervention | minutes (Mean) |
|---|---|
| Study: Melatonin | 20 |
| Control: Placebo | -55 |
25 reviews available for melatonin and Ache
| Article | Year |
|---|---|
Effect of melatonin on quality of life and symptoms in patients with cancer: a systematic review and meta-analysis of randomised controlled trials.
Topics: Adult; Fatigue; Humans; Melatonin; Neoplasms; Pain; Quality of Life; Randomized Controlled Trials as | 2022 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Melatonin in the treatment of fibromyalgia symptoms: A systematic review.
Topics: Fatigue; Fibromyalgia; Humans; Melatonin; Pain; Randomized Controlled Trials as Topic | 2020 |
Potential benefits of melatonin to control pain in ventilated preterm newborns: An updated review.
Topics: Analgesics; Antioxidants; Humans; Infant; Infant, Newborn; Infant, Premature; Melatonin; Pain | 2022 |
Primary Stabbing Headache.
Topics: Comorbidity; Diagnosis, Differential; Female; Headache Disorders, Primary; Humans; Indomethacin; Mal | 2019 |
Melatonin and its agonists in pain modulation and its clinical application.
Topics: Animals; Humans; Melatonin; Nociception; Pain; Pain Perception; Receptors, Melatonin | 2012 |
Restless legs syndrome and pain disorders: what's in common?
Topics: Calcium Channel Blockers; Diagnosis, Differential; Dopamine Agonists; Fibromyalgia; gamma-Aminobutyr | 2014 |
Analgesic, anxiolytic and anaesthetic effects of melatonin: new potential uses in pediatrics.
Topics: Analgesics; Anesthetics, General; Anti-Anxiety Agents; Anxiety Disorders; Brain Diseases; Child; Ele | 2015 |
The analgesic effects of exogenous melatonin in humans.
Topics: Administration, Topical; Central Nervous System Depressants; Humans; Melatonin; Pain; Treatment Outc | 2016 |
Melatonin: a hormone that modulates pain.
Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio | 2009 |
Melatonin: a hormone that modulates pain.
Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio | 2009 |
Melatonin: a hormone that modulates pain.
Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio | 2009 |
Melatonin: a hormone that modulates pain.
Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio | 2009 |
Melatonin: a hormone that modulates pain.
Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio | 2009 |
Melatonin: a hormone that modulates pain.
Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio | 2009 |
Melatonin: a hormone that modulates pain.
Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio | 2009 |
Melatonin: a hormone that modulates pain.
Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio | 2009 |
Melatonin: a hormone that modulates pain.
Topics: Analgesics; Animals; Humans; Melatonin; Pain; Pineal Gland; Receptors, Melatonin; Signal Transductio | 2009 |
Chapter 16: Melatonin and nerve regeneration.
Topics: Animals; Humans; Melatonin; Nerve Regeneration; Optic Nerve; Pain; Peripheral Nerve Injuries; Periph | 2009 |
Potential use of melatonergic drugs in analgesia: mechanisms of action.
Topics: Analgesics; Animals; Humans; Melatonin; Pain; Receptors, Melatonin | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Data Interpretation, Statistical; Female | 2010 |
Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies.
Topics: Analgesics; Animals; Disease Models, Animal; Fibromyalgia; Humans; Irritable Bowel Syndrome; Male; M | 2011 |
Antinociception by endogenous ligands at peripheral level.
Topics: Analgesics, Opioid; Animals; Annexin A1; beta-Endorphin; Cytokines; Endorphins; Excitatory Amino Aci | 2011 |
[Analgesic properties of pineal hormone melatonin].
Topics: Analgesics; Animals; Antioxidants; Humans; Hyperalgesia; Melatonin; Mice; Pain; Pineal Gland; Rats | 2012 |
Pain in the brain: are hormones to blame?
Topics: Adrenal Glands; Affect; Animals; Brain; Chronic Disease; Female; Growth Hormone; Hormones; Humans; H | 2003 |
Metabolic and endocrine effects of sedative agents.
Topics: Adrenergic alpha-Agonists; Analgesics; Analgesics, Opioid; Benzodiazepines; Catecholamines; Combined | 2005 |
Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases.
Topics: Aging; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Cell Physiological Phenomena; Cho | 2005 |
Sleep and aging: 2. Management of sleep disorders in older people.
Topics: Adjuvants, Immunologic; Aged; Aging; Antidepressive Agents; Behavior Therapy; Benzodiazepines; Demen | 2007 |
Neurobiological effects of melatonin as related to cancer.
Topics: Aging; Antineoplastic Agents; Biological Clocks; Clinical Trials as Topic; Drug Evaluation, Preclini | 2007 |
Resolution of Lhermitte's sign in multiple sclerosis by treatment with weak electromagnetic fields.
Topics: Adult; Axons; Brain; Demyelinating Diseases; Electromagnetic Phenomena; Female; Humans; Male; Melato | 1995 |
Pineal opioid receptors and analgesic action of melatonin.
Topics: Analgesia; Animals; Antioxidants; Circadian Rhythm; Free Radical Scavengers; Humans; Melatonin; Oxid | 1998 |
[Antioxidant effects of melatonin].
Topics: Analgesics; Antioxidants; Humans; Melatonin; Oxidative Stress; Pain | 2001 |
Pineal melatonin and sensory symptoms in Parkinson disease.
Topics: Animals; Humans; Melatonin; Neurons, Afferent; Pain; Parkinson Disease; Pineal Gland; Serotonin | 1989 |
15 trials available for melatonin and Ache
| Article | Year |
|---|---|
Oral melatonin did not reduce anxiety before elective hernia repair: A randomised, double-blinded, placebo-controlled trial.
Topics: Analgesics; Anti-Anxiety Agents; Anxiety; Herniorrhaphy; Humans; Melatonin; Pain | 2022 |
The Effect of Melatonin on Analgesia, Anxiety, and Intraocular Pressure (IOP) in Cataract Surgery Under Topical Anesthesia.
Topics: Analgesia; Anesthesia, Local; Anxiety; Cataract; Double-Blind Method; Humans; Intraocular Pressure; | 2023 |
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa | 2022 |
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa | 2022 |
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa | 2022 |
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa | 2022 |
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa | 2022 |
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa | 2022 |
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa | 2022 |
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa | 2022 |
Effectiveness of melatonin treatment for sleep disturbance in orthopaedic trauma patients: A prospective, randomized control trial.
Topics: Adult; Analgesics, Opioid; Humans; Melatonin; Middle Aged; Opioid-Related Disorders; Orthopedics; Pa | 2022 |
Comparison between oral melatonin and 24% sucrose for pain management during retinopathy of prematurity screening: a randomized controlled trial.
Topics: Birth Weight; Humans; Infant; Infant, Newborn; Melatonin; Pain; Pain Management; Pain Measurement; P | 2022 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
Both melatonin and meloxicam improved sleep and pain in females with primary dysmenorrhea-results from a double-blind cross-over intervention pilot study.
Topics: Adult; Antioxidants; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Dysmenorr | 2018 |
The effects of melatonin on anxiety and pain scores of patients, intraocular pressure, and operating conditions during cataract surgery under topical anesthesia.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anxiety; Central Nerv | 2013 |
Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial.
Topics: Adolescent; Adult; Amitriptyline; Analgesics; Brain-Derived Neurotrophic Factor; Double-Blind Method | 2014 |
Short- but not long-term melatonin administration reduces central levels of brain-derived neurotrophic factor in rats with inflammatory pain.
Topics: Analysis of Variance; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Central Nervous Syst | 2015 |
A Phase II, Randomized, Double-Blind, Placebo Controlled, Dose-Response Trial of the Melatonin Effect on the Pain Threshold of Healthy Subjects.
Topics: Administration, Sublingual; Adult; Analgesics; Anxiety; Brazil; Depression; Dose-Response Relationsh | 2013 |
Analgesic and antihyperalgesic effects of melatonin in a human inflammatory pain model: a randomized, double-blind, placebo-controlled, three-arm crossover study.
Topics: Adult; Analgesics; Analysis of Variance; Area Under Curve; Cross-Over Studies; Dose-Response Relatio | 2015 |
Melatonin improves tourniquet tolerance and enhances postoperative analgesia in patients receiving intravenous regional anesthesia.
Topics: Adjuvants, Anesthesia; Adult; Anesthetics, Local; Anti-Anxiety Agents; Double-Blind Method; Female; | 2008 |
Pain in neonatal intensive care: role of melatonin as an analgesic antioxidant.
Topics: Analgesics; Antioxidants; Humans; Infant, Newborn; Intensive Care, Neonatal; Melatonin; Pain; Prospe | 2012 |
Analgesic and sedative effects of melatonin in temporomandibular disorders: a double-blind, randomized, parallel-group, placebo-controlled study.
Topics: Adult; Analgesics, Non-Narcotic; Central Nervous System Depressants; Double-Blind Method; Female; Hu | 2013 |
The effect of melatonin in patients with fibromyalgia: a pilot study.
Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Fatigue Syndrome, Chronic; Female; Fibromyalgia; | 2000 |
45 other studies available for melatonin and Ache
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Killing pain?: a population-based registry study of the use of prescription analgesics, anxiolytics, and hypnotics among all children, adolescents and young adults in Norway from 2004 to 2019.
Topics: Adolescent; Adult; Analgesics; Analgesics, Opioid; Anti-Anxiety Agents; Child; Child, Preschool; Dru | 2023 |
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage.
Topics: Animals; Comorbidity; Disease Models, Animal; Hemorrhage; Humans; Melatonin; Pain; Sleep | 2022 |
The antinociceptive mechanisms of melatonin: role of L-arginine/nitric oxide/cyclic GMP/KATP channel signaling pathway.
Topics: Analgesics; Animals; Animals, Outbred Strains; Arginine; Cyclic GMP; KATP Channels; Male; Melatonin; | 2020 |
Role of endogenous melatoninergic system in development of hyperalgesia and tolerance induced by chronic morphine administration in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Drug Tolerance; Hyperalgesia; Male; | 2017 |
Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia.
Topics: Adult; Analgesics; Female; Fibromyalgia; Humans; Hydrocortisone; Male; Melatonin; Middle Aged; Mood | 2019 |
Melatonin treatment entrains the rest-activity circadian rhythm in rats with chronic inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Circadian Rhythm; Dexamethasone; Freund's Adjuvant; H | 2013 |
Perioperative melatonin: not ready for prime time.
Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep | 2014 |
Perioperative melatonin: not ready for prime time.
Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep | 2014 |
Perioperative melatonin: not ready for prime time.
Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep | 2014 |
Perioperative melatonin: not ready for prime time.
Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep | 2014 |
Perioperative melatonin: not ready for prime time.
Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep | 2014 |
Perioperative melatonin: not ready for prime time.
Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep | 2014 |
Perioperative melatonin: not ready for prime time.
Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep | 2014 |
Perioperative melatonin: not ready for prime time.
Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep | 2014 |
Perioperative melatonin: not ready for prime time.
Topics: Animals; Anxiety; Humans; Melatonin; Pain; Perioperative Period; Sleep | 2014 |
Anti-inflammatory activities of melatonin derivatives in lipopolysaccharide-stimulated RAW 264.7 cells and antinociceptive effects in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Dose-Response Rela | 2014 |
Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.
Topics: Actins; Adaptation, Physiological; Amino Acid Sequence; Animals; Ecosystem; Genetic Speciation; Geno | 2014 |
Behavioral Indexes of Thermal Nociceptive Sensitivity in Rats after Melatonin Administration.
Topics: Animals; Male; Melatonin; Nociception; Pain; Rats; Rats, Wistar | 2015 |
Potential positive feedback loop of pineal cyst and posttraumatic stress disorder.
Topics: Adult; Brain Neoplasms; Cysts; Female; Homeostasis; Humans; Incidental Findings; Magnetic Resonance | 2017 |
Possible participation of the nitric oxide-cyclic GMP-protein kinase G-K+ channels pathway in the peripheral antinociception of melatonin.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Female; Melatonin; Nitric Oxide; Pain; Pa | 2008 |
Is there a role of melatonin in the development of growing pains?
Topics: Age Factors; Child; Child, Preschool; Growth and Development; Humans; Leg; Melatonin; Pain | 2009 |
Evaluation for the interaction between intrathecal melatonin and clonidine or neostigmine on formalin-induced nociception.
Topics: Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Drug | 2008 |
[Chronopharmacology: exact timing of drug dose improves the treatment outcome].
Topics: Arthritis, Rheumatoid; Asthma; Cardiovascular Physiological Phenomena; Circadian Rhythm; Digestive S | 2009 |
Preliminary analgesic properties of deltorphin-5-methoxytryptamine chimeric opioid peptides.
Topics: 5-Methoxytryptamine; Analgesics; Animals; Male; Melatonin; Mice; Oligopeptides; Opioid Peptides; Pai | 2011 |
Receptors involved in the antinociception of intrathecal melatonin in formalin test of rats.
Topics: Animals; Central Nervous System Depressants; Formaldehyde; Injections, Spinal; Irritants; Male; Mela | 2011 |
Secretion of melatonin and 6-sulfatoxymelatonin urinary excretion in functional dyspepsia.
Topics: Adult; Circadian Rhythm; Diagnosis, Differential; Dyspepsia; Female; Humans; Male; Melatonin; Middle | 2011 |
[Sleep disorder and pain: the good hypnotic].
Topics: Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anticonvulsants; Behavior Therapy | 2011 |
Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; | 2002 |
The presence of delta and mu-, but not kappa or ORL(1) receptors in bovine pinealocytes.
Topics: Animals; Binding, Competitive; Cattle; Cell Membrane; Circadian Rhythm; Female; Melatonin; Narcotic | 2002 |
Gene expression and functional characterization of melatonin receptors in the spinal cord of the rat: implications for pain modulation.
Topics: Animals; Melatonin; Oocytes; Pain; Polymerase Chain Reaction; Rats; Receptors, Melatonin; RNA, Messe | 2003 |
Evaluation of the role of melatonin in formalin-induced pain response in mice.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Melatonin; Mice; Pain; Receptors, Adr | 2004 |
Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats.
Topics: Administration, Topical; Afferent Pathways; Animals; Capsaicin; Disease Models, Animal; Drug Interac | 2004 |
Diurnal changes of tonic nociceptive responses in mice: evidence for a proalgesic role of melatonin.
Topics: Animals; Autoradiography; Behavior, Animal; Binding Sites; Circadian Rhythm; Formaldehyde; Grooming; | 2004 |
Direct measurement of free radicals in the brain cortex and the blood serum after nociceptive stimulation in rats.
Topics: Analysis of Variance; Animals; Free Radicals; Hydroxyl Radical; Male; Melatonin; Nitrogen Oxides; Pa | 2004 |
Intrathecal melatonin increases the mechanical nociceptive threshold in the rat.
Topics: Animals; Drug Administration Schedule; Injections, Spinal; Male; Melatonin; Pain; Pain Measurement; | 2004 |
Mechanisms involved in the antinociception caused by melatonin in mice.
Topics: Adrenalectomy; Analgesics; Animals; Capsaicin; Male; Melatonin; Mice; Pain | 2006 |
Melatonin inhibits cortical spreading depression-evoked trigeminal nociception.
Topics: Animals; Cerebral Cortex; Cortical Spreading Depression; Endothelial Cells; Immunohistochemistry; Ma | 2006 |
Oral and spinal melatonin reduces tactile allodynia in rats via activation of MT2 and opioid receptors.
Topics: Administration, Oral; Animals; Female; Injections, Spinal; Melatonin; Pain; Physical Stimulation; Ra | 2007 |
Melatonin reduces formalin-induced nociception and tactile allodynia in diabetic rats.
Topics: Analgesics; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Female; Formaldehyde; Guanid | 2007 |
Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache.
Topics: Adult; Analysis of Variance; Circadian Rhythm; Cluster Headache; Female; Humans; Hydrocortisone; Mal | 1995 |
Melatonin and painful gynecomastia.
Topics: Amyotrophic Lateral Sclerosis; Gynecomastia; Humans; Male; Melatonin; Middle Aged; Pain; Pain Manage | 1999 |
The analgesic effects of peripheral and central administration of melatonin in rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Injections, Intr | 2000 |
Circadian rhythms of women with fibromyalgia.
Topics: Adult; Body Temperature; Circadian Rhythm; Female; Fibromyalgia; Food; Humans; Hydrocortisone; Light | 2001 |
Pain modulation role of melatonin in eating disorders.
Topics: Adult; Anorexia Nervosa; Bulimia; Enzyme-Linked Immunosorbent Assay; Female; Hospitalization; Humans | 2001 |
Salivary melatonin response to acute pain stimuli.
Topics: Acute Disease; Adult; Analgesia; Circadian Rhythm; Electroshock; Female; Humans; Male; Melatonin; Mi | 2001 |
Alteration of orphanin FQ immunoreactivity and ppOFQ mRNA by combination of melatonin with electroacupuncture.
Topics: Acupuncture Analgesia; Analgesics, Opioid; Animals; Brain Chemistry; Dose-Response Relationship, Dru | 2001 |
Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat?
Topics: Animals; Free Radical Scavengers; Free Radicals; Hyperalgesia; Male; Melatonin; Oxidative Stress; Pa | 2001 |
[Effects of the pineal body and melatonin on sensitivity to pain in mice].
Topics: Animals; Circadian Rhythm; Female; Melatonin; Meperidine; Mice; Morphine; Pain; Pineal Gland; Sensor | 1990 |
Discrimination of idiopathic pain syndromes from neurogenic pain syndromes and healthy volunteers by means of clinical rating, personality traits, monoamine metabolites in CSF, serum cortisol, platelet MAO and urinary melatonin.
Topics: Adult; Chronic Disease; Depressive Disorder; Female; Homovanillic Acid; Humans; Hydrocortisone; Hydr | 1986 |
Circadian rhythms in patients with abdominal pain syndromes.
Topics: Abdomen; Biliary Tract Diseases; Body Temperature Regulation; Cholecystectomy; Circadian Rhythm; Col | 1988 |
Melatonin in serum and urine in patients with idiopathic pain syndromes.
Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Female; Humans; Male; Melatonin; Middle Aged; Ne | 1987 |
Effect of neurotropin on hyperalgesia induced by prostaglandin E2, naloxone, melatonin and dark condition in mice.
Topics: Analgesics; Animals; Aspirin; Darkness; Dinoprostone; Formaldehyde; Male; Melatonin; Mice; Naloxone; | 1987 |