Page last updated: 2024-10-30

losartan and Sepsis

losartan has been researched along with Sepsis in 5 studies

Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Research Excerpts

ExcerptRelevanceReference
"We hypothesized that angiotensin II, a potent vasoconstrictor, is involved in the occurrence of hepatic ischemia after burn and sepsis, and that administration of angiotensin II antagonist DuP753 would ameliorate this process."7.70Trauma- and sepsis-induced hepatic ischemia and reperfusion injury: role of angiotensin II. ( Herndon, DN; Tadros, T; Traber, DL, 2000)
"Losartan treatment significantly attenuated TNF-alpha, IL-6, and IL-1beta 6 h after CLP."5.35Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappaB and mitogen-activated protein kinases. ( Cai, L; Kong, T; Mo, H; Qi, J; Shen, L; Xiao, Z; Ye, J; Zheng, W, 2009)
"We hypothesized that angiotensin II, a potent vasoconstrictor, is involved in the occurrence of hepatic ischemia after burn and sepsis, and that administration of angiotensin II antagonist DuP753 would ameliorate this process."3.70Trauma- and sepsis-induced hepatic ischemia and reperfusion injury: role of angiotensin II. ( Herndon, DN; Tadros, T; Traber, DL, 2000)
"Losartan treatment significantly attenuated TNF-alpha, IL-6, and IL-1beta 6 h after CLP."1.35Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappaB and mitogen-activated protein kinases. ( Cai, L; Kong, T; Mo, H; Qi, J; Shen, L; Xiao, Z; Ye, J; Zheng, W, 2009)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's2 (40.00)2.80

Authors

AuthorsStudies
Chen, XS1
Wang, SH1
Liu, CY1
Gao, YL1
Meng, XL1
Wei, W1
Shou, ST1
Liu, YC1
Chai, YF1
Leisman, DE1
Fernandes, TD1
Bijol, V1
Abraham, MN1
Lehman, JR1
Taylor, MD1
Capone, C1
Yaipan, O1
Bellomo, R1
Deutschman, CS1
Shen, L1
Mo, H1
Cai, L1
Kong, T1
Zheng, W1
Ye, J1
Qi, J1
Xiao, Z1
Yasuda, S1
Lew, WY1
Tadros, T1
Traber, DL1
Herndon, DN1

Other Studies

5 other studies available for losartan and Sepsis

ArticleYear
Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-κB and MAPK signaling.
    Pharmacological research, 2022, Volume: 185

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotens

2022
Impaired angiotensin II type 1 receptor signaling contributes to sepsis-induced acute kidney injury.
    Kidney international, 2021, Volume: 99, Issue:1

    Topics: Acute Kidney Injury; Angiotensin II; Animals; Case-Control Studies; Humans; Losartan; Mice; Receptor

2021
Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappaB and mitogen-activated protein kinases.
    Shock (Augusta, Ga.), 2009, Volume: 31, Issue:5

    Topics: Acute Lung Injury; Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; Interleukin-

2009
Angiotensin II exacerbates lipopolysaccharide-induced contractile depression in rabbit cardiac myocytes.
    The American journal of physiology, 1999, Volume: 276, Issue:5

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Calcium; Cells, Cultured; Chelating Agents; Cyclic

1999
Trauma- and sepsis-induced hepatic ischemia and reperfusion injury: role of angiotensin II.
    Archives of surgery (Chicago, Ill. : 1960), 2000, Volume: 135, Issue:7

    Topics: Analysis of Variance; Angiotensin II; Animals; Burns; Drug Evaluation, Preclinical; Escherichia coli

2000