Page last updated: 2024-10-30
losartan and Cough
losartan has been researched along with Cough in 32 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "135 hypertensive patients, all non-smokers, with angiotensin converting enzyme inhibitor cough confirmed by lisinopril rechallenge then placebo dechallenge." | 9.08 | Double-blind comparison of losartan, lisinopril and hydrochlorothiazide in hypertensive patients with a previous angiotensin converting enzyme inhibitor-associated cough. ( Ramsay, LE; Yeo, WW, 1995) |
| "One hundred and thirty five non-smoking hypertensive patients with ACE inhibitor cough confirmed by lisinopril rechallenge and placebo dechallenge were recruited into a double-blind random parallel-group comparison of losartan 50 mg, lisinopril 20 mg and hydrochlorothiazide 25 mg each given once daily for a maximum of 8 weeks." | 9.08 | ACE inhibitors, angiotensin II antagonists and cough. The Losartan Cough Study Group. ( Ramsay, LE; Yeo, WW, 1995) |
| "To evaluate the blood pressure lowering efficacy as well as tolerability and safety of the angiotensin II antagonist losartan compared with that of the angiotensin converting enzyme inhibitor enalapril in patients with mild-to-moderate essential hypertension." | 9.08 | Comparison of the angiotensin II antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension. ( Jensen, HA; Omvik, P; Tikkanen, I, 1995) |
| "This study compared the incidence of cough with the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the diuretic metolazone with angiotensin II receptor antagonist losartan in elderly hypertensive patients with previous histories of ACE inhibitor-induced cough." | 9.08 | Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough. ( Chan, P; Huang, TY; Ko, JT; Lee, YS; Lin, TS; Tomlinson, B, 1997) |
| "The percentage of patients who complained of cough was significantly higher with lisinopril than with losartan or hydrochlorothiazide." | 9.07 | Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group. ( Brunner, H; Dobbins, TW; Faison, EP; Irwin, R; Karlberg, BE; Lacourcière, Y; Nelson, EB; Ramsay, LE; Snavely, DB, 1994) |
| "Patients with a history of an ACE inhibitor-associated dry cough confirmed by a second challenge with lisinopril were enrolled into an international, multicenter, randomly allocated, double-blind, parallel-group, controlled trial, to be treated with losartan, lisinopril or hydrochlorothiazide." | 9.07 | Association between cough and angiotensin converting enzyme inhibitors versus angiotensin II antagonists: the design of a prospective, controlled study. ( Faison, EP; Lacourcière, Y; Lefebvre, J; Nakhle, G; Nelson, EB; Snavely, DB, 1994) |
| "Spontaneous rectus sheath haematomas and cough secondary to losartan are individually rare conditions." | 7.83 | Rare case of losartan-induced cough complicated by rectus sheath haematoma: in a patient on rivaroxaban therapy. ( Ahmed, S; Sweigart, J; Talari, G; Talari, P, 2016) |
| " The patient experienced cough 3 days following the initiation of losartan treatment." | 7.74 | Cough induced by losartan with resolution after substitution with enalapril. ( Ahmadi, F; Dashti-Khavidaki, S; Faghihi, T; Khalili, H, 2008) |
| "1%) were the clinical adverse experiences most often reported in patients treated with losartan." | 6.68 | Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension. ( Dunlay, MC; Goldberg, AI; Sweet, CS, 1995) |
| "Angioedema and cough are known side effects of angiotensin-converting enzyme (ACE) inhibitors." | 5.31 | Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema. ( Abdi, R; Dong, VM; Lee, CJ; Ntoso, KA, 2002) |
| "135 hypertensive patients, all non-smokers, with angiotensin converting enzyme inhibitor cough confirmed by lisinopril rechallenge then placebo dechallenge." | 5.08 | Double-blind comparison of losartan, lisinopril and hydrochlorothiazide in hypertensive patients with a previous angiotensin converting enzyme inhibitor-associated cough. ( Ramsay, LE; Yeo, WW, 1995) |
| "One hundred and thirty five non-smoking hypertensive patients with ACE inhibitor cough confirmed by lisinopril rechallenge and placebo dechallenge were recruited into a double-blind random parallel-group comparison of losartan 50 mg, lisinopril 20 mg and hydrochlorothiazide 25 mg each given once daily for a maximum of 8 weeks." | 5.08 | ACE inhibitors, angiotensin II antagonists and cough. The Losartan Cough Study Group. ( Ramsay, LE; Yeo, WW, 1995) |
| "To evaluate the blood pressure lowering efficacy as well as tolerability and safety of the angiotensin II antagonist losartan compared with that of the angiotensin converting enzyme inhibitor enalapril in patients with mild-to-moderate essential hypertension." | 5.08 | Comparison of the angiotensin II antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension. ( Jensen, HA; Omvik, P; Tikkanen, I, 1995) |
| "This study compared the incidence of cough with the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the diuretic metolazone with angiotensin II receptor antagonist losartan in elderly hypertensive patients with previous histories of ACE inhibitor-induced cough." | 5.08 | Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough. ( Chan, P; Huang, TY; Ko, JT; Lee, YS; Lin, TS; Tomlinson, B, 1997) |
| "The percentage of patients who complained of cough was significantly higher with lisinopril than with losartan or hydrochlorothiazide." | 5.07 | Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group. ( Brunner, H; Dobbins, TW; Faison, EP; Irwin, R; Karlberg, BE; Lacourcière, Y; Nelson, EB; Ramsay, LE; Snavely, DB, 1994) |
| "Patients with a history of an ACE inhibitor-associated dry cough confirmed by a second challenge with lisinopril were enrolled into an international, multicenter, randomly allocated, double-blind, parallel-group, controlled trial, to be treated with losartan, lisinopril or hydrochlorothiazide." | 5.07 | Association between cough and angiotensin converting enzyme inhibitors versus angiotensin II antagonists: the design of a prospective, controlled study. ( Faison, EP; Lacourcière, Y; Lefebvre, J; Nakhle, G; Nelson, EB; Snavely, DB, 1994) |
| "Enalapril has similar effects to losartan on systemic blood pressure, renal function and serum UA in patients with CKD, but carries a higher risk of dry cough." | 4.89 | Enalapril versus losartan for adults with chronic kidney disease: a systematic review and meta-analysis. ( Feng, L; He, YM; Huo, DM; Liao, YH; Yang, ZH, 2013) |
| "Spontaneous rectus sheath haematomas and cough secondary to losartan are individually rare conditions." | 3.83 | Rare case of losartan-induced cough complicated by rectus sheath haematoma: in a patient on rivaroxaban therapy. ( Ahmed, S; Sweigart, J; Talari, G; Talari, P, 2016) |
| "The aim of the present study was to analyze differences in cough induction between losartan and lisinopril in both anaesthetized and awake rabbits, i." | 3.79 | Comparison between the effects of lisinopril and losartan on the cougn reflex in anesthetized and awake rabbits. ( Bongianni, F; Cinelli, E; Evangelista, S; Mutolo, D; Pantaleo, T, 2013) |
| " The patient experienced cough 3 days following the initiation of losartan treatment." | 3.74 | Cough induced by losartan with resolution after substitution with enalapril. ( Ahmadi, F; Dashti-Khavidaki, S; Faghihi, T; Khalili, H, 2008) |
| "Arterial hypertension significantly decreased after the introduction of losartan (p = 0." | 3.72 | Renoprotective effects of losartan in renal transplant recipients. Results of a retrospective study. ( Anaya, F; Campistol, JM; Del Castillo, D; Esforzado, N; Iñigo, P; Navarro, MD; Oppenheimer, F; Saracho, R, 2003) |
| "Cough is one of the most frequent side effects associated with angiotensin converting enzyme inhibitors (ACEIs) but is not thought to be associated with losartan, an angiotensin II receptor antagonist (ARA)." | 3.70 | Cough and angiotensin II receptor antagonists: cause or confounding? ( Mackay, FJ; Mann, RD; Pearce, GL, 1999) |
| "1%) were the clinical adverse experiences most often reported in patients treated with losartan." | 2.68 | Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension. ( Dunlay, MC; Goldberg, AI; Sweet, CS, 1995) |
| "Losartan generated a lower incidence than angiotensin-converting enzyme inhibitors of reported dry cough (risk ratio 0." | 2.52 | Losartan treatment for hypertensive patients with hyperuricaemia in Chinese population: a meta-analysis. ( Fan, Y; Lang, Y; Wang, S; Wei, F, 2015) |
| "Angioedema was not reported in the comparative trials described." | 2.40 | ACE inhibitor- versus angiotensin II blocker-induced cough and angioedema. ( Pylypchuk, GB, 1998) |
| "Only dizziness was more often considered drug-related in losartan-treated patients (2." | 2.39 | Safety and tolerability of losartan compared with atenolol, felodipine and angiotensin converting enzyme inhibitors. ( Dunlay, MC; Goldberg, AI; Sweet, CS, 1995) |
| "Dry cough is the most common and annoying, although harmless, side effect associated with the use of ACE inhibitors." | 2.38 | Cough and inhibition of the renin-angiotensin system. ( Karlberg, BE, 1993) |
| "Angioedema and cough are known side effects of angiotensin-converting enzyme (ACE) inhibitors." | 1.31 | Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema. ( Abdi, R; Dong, VM; Lee, CJ; Ntoso, KA, 2002) |
Research
Studies (32)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (53.13) | 18.2507 |
| 2000's | 11 (34.38) | 29.6817 |
| 2010's | 4 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Mutolo, D | 1 |
| Cinelli, E | 1 |
| Bongianni, F | 1 |
| Evangelista, S | 1 |
| Pantaleo, T | 1 |
| He, YM | 1 |
| Feng, L | 1 |
| Huo, DM | 1 |
| Yang, ZH | 1 |
| Liao, YH | 1 |
| Fan, Y | 1 |
| Wei, F | 1 |
| Lang, Y | 1 |
| Wang, S | 1 |
| Talari, G | 1 |
| Talari, P | 1 |
| Sweigart, J | 1 |
| Ahmed, S | 1 |
| Kamal, Z | 1 |
| Nordstad, MG | 1 |
| Molden, E | 1 |
| Ramsay, LE | 3 |
| Yeo, WW | 2 |
| Goldberg, AI | 3 |
| Dunlay, MC | 2 |
| Sweet, CS | 3 |
| Abdi, R | 1 |
| Dong, VM | 1 |
| Lee, CJ | 1 |
| Ntoso, KA | 1 |
| Samizo, K | 1 |
| Kawabe, E | 1 |
| Hinotsu, S | 1 |
| Sato, T | 1 |
| Kageyama, S | 2 |
| Hamada, C | 1 |
| Ohashi, Y | 1 |
| Kubota, K | 1 |
| Iñigo, P | 1 |
| Campistol, JM | 1 |
| Saracho, R | 1 |
| Del Castillo, D | 1 |
| Anaya, F | 1 |
| Esforzado, N | 1 |
| Navarro, MD | 1 |
| Oppenheimer, F | 1 |
| Wu, SC | 1 |
| Liu, CP | 1 |
| Chiang, HT | 1 |
| Lin, SL | 1 |
| Dashti-Khavidaki, S | 1 |
| Faghihi, T | 1 |
| Ahmadi, F | 1 |
| Khalili, H | 1 |
| Lacourcière, Y | 2 |
| Brunner, H | 1 |
| Irwin, R | 1 |
| Karlberg, BE | 2 |
| Snavely, DB | 2 |
| Dobbins, TW | 1 |
| Faison, EP | 2 |
| Nelson, EB | 2 |
| Lefebvre, J | 1 |
| Nakhle, G | 1 |
| Ruilope, LM | 1 |
| Simpson, RL | 1 |
| Toh, J | 1 |
| Arcuri, KE | 1 |
| Donati-Genet, P | 1 |
| Bianchetti, MG | 1 |
| Tikkanen, I | 1 |
| Omvik, P | 1 |
| Jensen, HA | 1 |
| Chan, P | 1 |
| Tomlinson, B | 1 |
| Huang, TY | 1 |
| Ko, JT | 1 |
| Lin, TS | 1 |
| Lee, YS | 1 |
| Pylypchuk, GB | 1 |
| Mackay, FJ | 1 |
| Pearce, GL | 1 |
| Mann, RD | 1 |
| Conigliaro, RL | 2 |
| Gleason, PP | 2 |
| Mann, R | 1 |
| Mackay, F | 1 |
| Pearce, G | 1 |
| Freemantle, S | 1 |
| Wilton, L | 1 |
| Lee, YJ | 1 |
| Chiang, YF | 1 |
| Tsai, JC | 1 |
| Vidt, DG | 1 |
| Fruhwald, FM | 1 |
| Kickenweiz, E | 1 |
| Zweiker, R | 1 |
| Klein, W | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Allopurinol in the Treatment of Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Treated by Either PCI or CABG: Pilot Study[NCT03700645] | Phase 4 | 100 participants (Anticipated) | Interventional | 2018-12-01 | Not yet recruiting | ||
| No Pharmacokinetic Interaction Between Chlorthalidone and Losartan, in Healthy Volunteers Under Fasting Conditions, Administered in Fixed Combination Against Individual Components Administered Jointly and Separately[NCT05090449] | Phase 1 | 36 participants (Actual) | Interventional | 2019-05-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
7 reviews available for losartan and Cough
| Article | Year |
|---|---|
Enalapril versus losartan for adults with chronic kidney disease: a systematic review and meta-analysis.
Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Biom | 2013 |
Losartan treatment for hypertensive patients with hyperuricaemia in Chinese population: a meta-analysis.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive | 2015 |
Safety and tolerability of losartan compared with atenolol, felodipine and angiotensin converting enzyme inhibitors.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers | 1995 |
[Clinical trials of ACE inhibitors and ARB for treatment of patients with hypertension, heart failure, and diabetic nephropathy in Japan--special reference to the dosage schedule and adverse effects].
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; B | 2008 |
Cough and inhibition of the renin-angiotensin system.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Coug | 1993 |
ACE inhibitor- versus angiotensin II blocker-induced cough and angioedema.
Topics: Angioedema; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihyperten | 1998 |
[Angiotensin I receptor blockers for heart failure].
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; | 2001 |
Trials
10 trials available for losartan and Cough
| Article | Year |
|---|---|
Double-blind comparison of losartan, lisinopril and hydrochlorothiazide in hypertensive patients with a previous angiotensin converting enzyme inhibitor-associated cough.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cough; Diuretics; | 1995 |
Prospective and randomized study of the antihypertensive effect and tolerability of three antihypertensive agents, losartan, amlodipine, and lisinopril, in hypertensive patients.
Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; | 2004 |
Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group.
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Biphenyl Compounds; Cough; Double-Blind Method; Femal | 1994 |
Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension.
Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Conver | 1995 |
Association between cough and angiotensin converting enzyme inhibitors versus angiotensin II antagonists: the design of a prospective, controlled study.
Topics: Adult; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Cough; Double-Blind Method; Fema | 1994 |
ACE inhibitors, angiotensin II antagonists and cough. The Losartan Cough Study Group.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; | 1995 |
Controlled trial of losartan given concomitantly with different doses of hydrochlorothiazide in hypertensive patients.
Topics: Adult; Antihypertensive Agents; Asthenia; Biphenyl Compounds; Blood Pressure; Controlled Clinical Tr | 1996 |
Comparison of the angiotensin II antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension.
Topics: Adult; Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Blood Pre | 1995 |
Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough.
Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzothi | 1997 |
Severe nonproductive cough and cough-induced stress urinary incontinence in diabetic postmenopausal women treated with ACE inhibitor.
Topics: Angiotensin-Converting Enzyme Inhibitors; Cough; Diabetic Angiopathies; Double-Blind Method; Female; | 2000 |
Other Studies
15 other studies available for losartan and Cough
| Article | Year |
|---|---|
Comparison between the effects of lisinopril and losartan on the cougn reflex in anesthetized and awake rabbits.
Topics: Administration, Inhalation; Administration, Intravenous; Anesthesia; Angiotensin II Type 1 Receptor | 2013 |
Rare case of losartan-induced cough complicated by rectus sheath haematoma: in a patient on rivaroxaban therapy.
Topics: Aged; Antihypertensive Agents; Cough; Diagnosis, Differential; Factor Xa Inhibitors; Hematoma; Human | 2016 |
[A 60-year-old man with heart failure, dry cough and elevated INR values].
Topics: Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Coronary Th | 2008 |
Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema.
Topics: Adult; Angioedema; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme I | 2002 |
Comparison of losartan with ACE inhibitors and dihydropyridine calcium channel antagonists: a pilot study of prescription-event monitoring in Japan.
Topics: Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Chi- | 2002 |
Renoprotective effects of losartan in renal transplant recipients. Results of a retrospective study.
Topics: Anemia; Antihypertensive Agents; Cough; Creatinine; Female; Follow-Up Studies; Humans; Hyperkalemia; | 2003 |
Cough induced by losartan with resolution after substitution with enalapril.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cough; Ena | 2008 |
[Bronchospasm and cough connected to Losartan].
Topics: Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Bronchial Spasm; Cough; Humans; Imidazo | 1995 |
Modulators of the renin-angiotensin-aldosterone system and cough in childhood.
Topics: Adolescent; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Com | 1996 |
[News on side effects. 59 reports on losartan. Even cough is reported].
Topics: Adverse Drug Reaction Reporting Systems; Anti-Arrhythmia Agents; Antihypertensive Agents; Biphenyl C | 1996 |
Cough and angiotensin II receptor antagonists: cause or confounding?
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Cohort Studies; Confounding Factors, Epidemiologic; | 1999 |
Losartan-induced cough after lisinopril therapy.
Topics: Aged; Angiotensin II; Antihypertensive Agents; Cough; Female; Humans; Lisinopril; Losartan; Randomiz | 1999 |
Losartan: a study of pharmacovigilance data on 14,522 patients.
Topics: Age Distribution; Aged; Antihypertensive Agents; Cohort Studies; Cough; Dizziness; Female; Humans; I | 1999 |
Losartan-induced cough after lisinopril therapy.
Topics: Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; | 2000 |
Can angiotensin II receptor blockers be used in patients who have developed a cough or angioedema as a result of taking an ACE inhibitor?
Topics: Acrylates; Angioedema; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzy | 2001 |