Page last updated: 2024-10-30

losartan and Cough

losartan has been researched along with Cough in 32 studies

Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.

Research Excerpts

ExcerptRelevanceReference
"135 hypertensive patients, all non-smokers, with angiotensin converting enzyme inhibitor cough confirmed by lisinopril rechallenge then placebo dechallenge."9.08Double-blind comparison of losartan, lisinopril and hydrochlorothiazide in hypertensive patients with a previous angiotensin converting enzyme inhibitor-associated cough. ( Ramsay, LE; Yeo, WW, 1995)
"One hundred and thirty five non-smoking hypertensive patients with ACE inhibitor cough confirmed by lisinopril rechallenge and placebo dechallenge were recruited into a double-blind random parallel-group comparison of losartan 50 mg, lisinopril 20 mg and hydrochlorothiazide 25 mg each given once daily for a maximum of 8 weeks."9.08ACE inhibitors, angiotensin II antagonists and cough. The Losartan Cough Study Group. ( Ramsay, LE; Yeo, WW, 1995)
"To evaluate the blood pressure lowering efficacy as well as tolerability and safety of the angiotensin II antagonist losartan compared with that of the angiotensin converting enzyme inhibitor enalapril in patients with mild-to-moderate essential hypertension."9.08Comparison of the angiotensin II antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension. ( Jensen, HA; Omvik, P; Tikkanen, I, 1995)
"This study compared the incidence of cough with the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the diuretic metolazone with angiotensin II receptor antagonist losartan in elderly hypertensive patients with previous histories of ACE inhibitor-induced cough."9.08Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough. ( Chan, P; Huang, TY; Ko, JT; Lee, YS; Lin, TS; Tomlinson, B, 1997)
"The percentage of patients who complained of cough was significantly higher with lisinopril than with losartan or hydrochlorothiazide."9.07Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group. ( Brunner, H; Dobbins, TW; Faison, EP; Irwin, R; Karlberg, BE; Lacourcière, Y; Nelson, EB; Ramsay, LE; Snavely, DB, 1994)
"Patients with a history of an ACE inhibitor-associated dry cough confirmed by a second challenge with lisinopril were enrolled into an international, multicenter, randomly allocated, double-blind, parallel-group, controlled trial, to be treated with losartan, lisinopril or hydrochlorothiazide."9.07Association between cough and angiotensin converting enzyme inhibitors versus angiotensin II antagonists: the design of a prospective, controlled study. ( Faison, EP; Lacourcière, Y; Lefebvre, J; Nakhle, G; Nelson, EB; Snavely, DB, 1994)
"Spontaneous rectus sheath haematomas and cough secondary to losartan are individually rare conditions."7.83Rare case of losartan-induced cough complicated by rectus sheath haematoma: in a patient on rivaroxaban therapy. ( Ahmed, S; Sweigart, J; Talari, G; Talari, P, 2016)
" The patient experienced cough 3 days following the initiation of losartan treatment."7.74Cough induced by losartan with resolution after substitution with enalapril. ( Ahmadi, F; Dashti-Khavidaki, S; Faghihi, T; Khalili, H, 2008)
"1%) were the clinical adverse experiences most often reported in patients treated with losartan."6.68Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension. ( Dunlay, MC; Goldberg, AI; Sweet, CS, 1995)
"Angioedema and cough are known side effects of angiotensin-converting enzyme (ACE) inhibitors."5.31Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema. ( Abdi, R; Dong, VM; Lee, CJ; Ntoso, KA, 2002)
"135 hypertensive patients, all non-smokers, with angiotensin converting enzyme inhibitor cough confirmed by lisinopril rechallenge then placebo dechallenge."5.08Double-blind comparison of losartan, lisinopril and hydrochlorothiazide in hypertensive patients with a previous angiotensin converting enzyme inhibitor-associated cough. ( Ramsay, LE; Yeo, WW, 1995)
"One hundred and thirty five non-smoking hypertensive patients with ACE inhibitor cough confirmed by lisinopril rechallenge and placebo dechallenge were recruited into a double-blind random parallel-group comparison of losartan 50 mg, lisinopril 20 mg and hydrochlorothiazide 25 mg each given once daily for a maximum of 8 weeks."5.08ACE inhibitors, angiotensin II antagonists and cough. The Losartan Cough Study Group. ( Ramsay, LE; Yeo, WW, 1995)
"To evaluate the blood pressure lowering efficacy as well as tolerability and safety of the angiotensin II antagonist losartan compared with that of the angiotensin converting enzyme inhibitor enalapril in patients with mild-to-moderate essential hypertension."5.08Comparison of the angiotensin II antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension. ( Jensen, HA; Omvik, P; Tikkanen, I, 1995)
"This study compared the incidence of cough with the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the diuretic metolazone with angiotensin II receptor antagonist losartan in elderly hypertensive patients with previous histories of ACE inhibitor-induced cough."5.08Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough. ( Chan, P; Huang, TY; Ko, JT; Lee, YS; Lin, TS; Tomlinson, B, 1997)
"The percentage of patients who complained of cough was significantly higher with lisinopril than with losartan or hydrochlorothiazide."5.07Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group. ( Brunner, H; Dobbins, TW; Faison, EP; Irwin, R; Karlberg, BE; Lacourcière, Y; Nelson, EB; Ramsay, LE; Snavely, DB, 1994)
"Patients with a history of an ACE inhibitor-associated dry cough confirmed by a second challenge with lisinopril were enrolled into an international, multicenter, randomly allocated, double-blind, parallel-group, controlled trial, to be treated with losartan, lisinopril or hydrochlorothiazide."5.07Association between cough and angiotensin converting enzyme inhibitors versus angiotensin II antagonists: the design of a prospective, controlled study. ( Faison, EP; Lacourcière, Y; Lefebvre, J; Nakhle, G; Nelson, EB; Snavely, DB, 1994)
"Enalapril has similar effects to losartan on systemic blood pressure, renal function and serum UA in patients with CKD, but carries a higher risk of dry cough."4.89Enalapril versus losartan for adults with chronic kidney disease: a systematic review and meta-analysis. ( Feng, L; He, YM; Huo, DM; Liao, YH; Yang, ZH, 2013)
"Spontaneous rectus sheath haematomas and cough secondary to losartan are individually rare conditions."3.83Rare case of losartan-induced cough complicated by rectus sheath haematoma: in a patient on rivaroxaban therapy. ( Ahmed, S; Sweigart, J; Talari, G; Talari, P, 2016)
"The aim of the present study was to analyze differences in cough induction between losartan and lisinopril in both anaesthetized and awake rabbits, i."3.79Comparison between the effects of lisinopril and losartan on the cougn reflex in anesthetized and awake rabbits. ( Bongianni, F; Cinelli, E; Evangelista, S; Mutolo, D; Pantaleo, T, 2013)
" The patient experienced cough 3 days following the initiation of losartan treatment."3.74Cough induced by losartan with resolution after substitution with enalapril. ( Ahmadi, F; Dashti-Khavidaki, S; Faghihi, T; Khalili, H, 2008)
"Arterial hypertension significantly decreased after the introduction of losartan (p = 0."3.72Renoprotective effects of losartan in renal transplant recipients. Results of a retrospective study. ( Anaya, F; Campistol, JM; Del Castillo, D; Esforzado, N; Iñigo, P; Navarro, MD; Oppenheimer, F; Saracho, R, 2003)
"Cough is one of the most frequent side effects associated with angiotensin converting enzyme inhibitors (ACEIs) but is not thought to be associated with losartan, an angiotensin II receptor antagonist (ARA)."3.70Cough and angiotensin II receptor antagonists: cause or confounding? ( Mackay, FJ; Mann, RD; Pearce, GL, 1999)
"1%) were the clinical adverse experiences most often reported in patients treated with losartan."2.68Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension. ( Dunlay, MC; Goldberg, AI; Sweet, CS, 1995)
"Losartan generated a lower incidence than angiotensin-converting enzyme inhibitors of reported dry cough (risk ratio 0."2.52Losartan treatment for hypertensive patients with hyperuricaemia in Chinese population: a meta-analysis. ( Fan, Y; Lang, Y; Wang, S; Wei, F, 2015)
"Angioedema was not reported in the comparative trials described."2.40ACE inhibitor- versus angiotensin II blocker-induced cough and angioedema. ( Pylypchuk, GB, 1998)
"Only dizziness was more often considered drug-related in losartan-treated patients (2."2.39Safety and tolerability of losartan compared with atenolol, felodipine and angiotensin converting enzyme inhibitors. ( Dunlay, MC; Goldberg, AI; Sweet, CS, 1995)
"Dry cough is the most common and annoying, although harmless, side effect associated with the use of ACE inhibitors."2.38Cough and inhibition of the renin-angiotensin system. ( Karlberg, BE, 1993)
"Angioedema and cough are known side effects of angiotensin-converting enzyme (ACE) inhibitors."1.31Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema. ( Abdi, R; Dong, VM; Lee, CJ; Ntoso, KA, 2002)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's17 (53.13)18.2507
2000's11 (34.38)29.6817
2010's4 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mutolo, D1
Cinelli, E1
Bongianni, F1
Evangelista, S1
Pantaleo, T1
He, YM1
Feng, L1
Huo, DM1
Yang, ZH1
Liao, YH1
Fan, Y1
Wei, F1
Lang, Y1
Wang, S1
Talari, G1
Talari, P1
Sweigart, J1
Ahmed, S1
Kamal, Z1
Nordstad, MG1
Molden, E1
Ramsay, LE3
Yeo, WW2
Goldberg, AI3
Dunlay, MC2
Sweet, CS3
Abdi, R1
Dong, VM1
Lee, CJ1
Ntoso, KA1
Samizo, K1
Kawabe, E1
Hinotsu, S1
Sato, T1
Kageyama, S2
Hamada, C1
Ohashi, Y1
Kubota, K1
Iñigo, P1
Campistol, JM1
Saracho, R1
Del Castillo, D1
Anaya, F1
Esforzado, N1
Navarro, MD1
Oppenheimer, F1
Wu, SC1
Liu, CP1
Chiang, HT1
Lin, SL1
Dashti-Khavidaki, S1
Faghihi, T1
Ahmadi, F1
Khalili, H1
Lacourcière, Y2
Brunner, H1
Irwin, R1
Karlberg, BE2
Snavely, DB2
Dobbins, TW1
Faison, EP2
Nelson, EB2
Lefebvre, J1
Nakhle, G1
Ruilope, LM1
Simpson, RL1
Toh, J1
Arcuri, KE1
Donati-Genet, P1
Bianchetti, MG1
Tikkanen, I1
Omvik, P1
Jensen, HA1
Chan, P1
Tomlinson, B1
Huang, TY1
Ko, JT1
Lin, TS1
Lee, YS1
Pylypchuk, GB1
Mackay, FJ1
Pearce, GL1
Mann, RD1
Conigliaro, RL2
Gleason, PP2
Mann, R1
Mackay, F1
Pearce, G1
Freemantle, S1
Wilton, L1
Lee, YJ1
Chiang, YF1
Tsai, JC1
Vidt, DG1
Fruhwald, FM1
Kickenweiz, E1
Zweiker, R1
Klein, W1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Allopurinol in the Treatment of Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Treated by Either PCI or CABG: Pilot Study[NCT03700645]Phase 4100 participants (Anticipated)Interventional2018-12-01Not yet recruiting
No Pharmacokinetic Interaction Between Chlorthalidone and Losartan, in Healthy Volunteers Under Fasting Conditions, Administered in Fixed Combination Against Individual Components Administered Jointly and Separately[NCT05090449]Phase 136 participants (Actual)Interventional2019-05-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for losartan and Cough

ArticleYear
Enalapril versus losartan for adults with chronic kidney disease: a systematic review and meta-analysis.
    Nephrology (Carlton, Vic.), 2013, Volume: 18, Issue:9

    Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Biom

2013
Losartan treatment for hypertensive patients with hyperuricaemia in Chinese population: a meta-analysis.
    Journal of hypertension, 2015, Volume: 33, Issue:4

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive

2015
Safety and tolerability of losartan compared with atenolol, felodipine and angiotensin converting enzyme inhibitors.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1995, Volume: 13, Issue:1

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin II Type 1 Receptor Blockers

1995
[Clinical trials of ACE inhibitors and ARB for treatment of patients with hypertension, heart failure, and diabetic nephropathy in Japan--special reference to the dosage schedule and adverse effects].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2008, Volume: 131, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; B

2008
Cough and inhibition of the renin-angiotensin system.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1993, Volume: 11, Issue:3

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Coug

1993
ACE inhibitor- versus angiotensin II blocker-induced cough and angioedema.
    The Annals of pharmacotherapy, 1998, Volume: 32, Issue:10

    Topics: Angioedema; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihyperten

1998
[Angiotensin I receptor blockers for heart failure].
    Wiener medizinische Wochenschrift (1946), 2001, Volume: 151, Issue:7-8

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents;

2001

Trials

10 trials available for losartan and Cough

ArticleYear
Double-blind comparison of losartan, lisinopril and hydrochlorothiazide in hypertensive patients with a previous angiotensin converting enzyme inhibitor-associated cough.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1995, Volume: 13, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cough; Diuretics;

1995
Prospective and randomized study of the antihypertensive effect and tolerability of three antihypertensive agents, losartan, amlodipine, and lisinopril, in hypertensive patients.
    Heart and vessels, 2004, Volume: 19, Issue:1

    Topics: Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure;

2004
Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group.
    Journal of hypertension, 1994, Volume: 12, Issue:12

    Topics: Adult; Aged; Angiotensin Receptor Antagonists; Biphenyl Compounds; Cough; Double-Blind Method; Femal

1994
Safety and tolerability of losartan potassium, an angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension.
    The American journal of cardiology, 1995, Apr-15, Volume: 75, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Conver

1995
Association between cough and angiotensin converting enzyme inhibitors versus angiotensin II antagonists: the design of a prospective, controlled study.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1994, Volume: 12, Issue:2

    Topics: Adult; Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Cough; Double-Blind Method; Fema

1994
ACE inhibitors, angiotensin II antagonists and cough. The Losartan Cough Study Group.
    Journal of human hypertension, 1995, Volume: 9 Suppl 5

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds;

1995
Controlled trial of losartan given concomitantly with different doses of hydrochlorothiazide in hypertensive patients.
    Blood pressure, 1996, Volume: 5, Issue:1

    Topics: Adult; Antihypertensive Agents; Asthenia; Biphenyl Compounds; Blood Pressure; Controlled Clinical Tr

1996
Comparison of the angiotensin II antagonist losartan with the angiotensin converting enzyme inhibitor enalapril in patients with essential hypertension.
    Journal of hypertension, 1995, Volume: 13, Issue:11

    Topics: Adult; Aged; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Compounds; Blood Pre

1995
Double-blind comparison of losartan, lisinopril, and metolazone in elderly hypertensive patients with previous angiotensin-converting enzyme inhibitor-induced cough.
    Journal of clinical pharmacology, 1997, Volume: 37, Issue:3

    Topics: Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzothi

1997
Severe nonproductive cough and cough-induced stress urinary incontinence in diabetic postmenopausal women treated with ACE inhibitor.
    Diabetes care, 2000, Volume: 23, Issue:3

    Topics: Angiotensin-Converting Enzyme Inhibitors; Cough; Diabetic Angiopathies; Double-Blind Method; Female;

2000

Other Studies

15 other studies available for losartan and Cough

ArticleYear
Comparison between the effects of lisinopril and losartan on the cougn reflex in anesthetized and awake rabbits.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2013, Volume: 64, Issue:2

    Topics: Administration, Inhalation; Administration, Intravenous; Anesthesia; Angiotensin II Type 1 Receptor

2013
Rare case of losartan-induced cough complicated by rectus sheath haematoma: in a patient on rivaroxaban therapy.
    BMJ case reports, 2016, Dec-23, Volume: 2016

    Topics: Aged; Antihypertensive Agents; Cough; Diagnosis, Differential; Factor Xa Inhibitors; Hematoma; Human

2016
[A 60-year-old man with heart failure, dry cough and elevated INR values].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2008, Aug-14, Volume: 128, Issue:15

    Topics: Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Coronary Th

2008
Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema.
    Pharmacotherapy, 2002, Volume: 22, Issue:9

    Topics: Adult; Angioedema; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme I

2002
Comparison of losartan with ACE inhibitors and dihydropyridine calcium channel antagonists: a pilot study of prescription-event monitoring in Japan.
    Drug safety, 2002, Volume: 25, Issue:11

    Topics: Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Chi-

2002
Renoprotective effects of losartan in renal transplant recipients. Results of a retrospective study.
    Nephron. Clinical practice, 2003, Volume: 95, Issue:3

    Topics: Anemia; Antihypertensive Agents; Cough; Creatinine; Female; Follow-Up Studies; Humans; Hyperkalemia;

2003
Cough induced by losartan with resolution after substitution with enalapril.
    Clinical therapeutics, 2008, Volume: 30, Issue:3

    Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Cough; Ena

2008
[Bronchospasm and cough connected to Losartan].
    Lakartidningen, 1995, Oct-18, Volume: 92, Issue:42

    Topics: Angiotensin II; Antihypertensive Agents; Biphenyl Compounds; Bronchial Spasm; Cough; Humans; Imidazo

1995
Modulators of the renin-angiotensin-aldosterone system and cough in childhood.
    Pediatric nephrology (Berlin, Germany), 1996, Volume: 10, Issue:4

    Topics: Adolescent; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biphenyl Com

1996
[News on side effects. 59 reports on losartan. Even cough is reported].
    Lakartidningen, 1996, Oct-09, Volume: 93, Issue:41

    Topics: Adverse Drug Reaction Reporting Systems; Anti-Arrhythmia Agents; Antihypertensive Agents; Biphenyl C

1996
Cough and angiotensin II receptor antagonists: cause or confounding?
    British journal of clinical pharmacology, 1999, Volume: 47, Issue:1

    Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Cohort Studies; Confounding Factors, Epidemiologic;

1999
Losartan-induced cough after lisinopril therapy.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1999, May-01, Volume: 56, Issue:9

    Topics: Aged; Angiotensin II; Antihypertensive Agents; Cough; Female; Humans; Lisinopril; Losartan; Randomiz

1999
Losartan: a study of pharmacovigilance data on 14,522 patients.
    Journal of human hypertension, 1999, Volume: 13, Issue:8

    Topics: Age Distribution; Aged; Antihypertensive Agents; Cohort Studies; Cough; Dizziness; Female; Humans; I

1999
Losartan-induced cough after lisinopril therapy.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2000, May-15, Volume: 57, Issue:10

    Topics: Aged; Aged, 80 and over; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors;

2000
Can angiotensin II receptor blockers be used in patients who have developed a cough or angioedema as a result of taking an ACE inhibitor?
    Cleveland Clinic journal of medicine, 2001, Volume: 68, Issue:3

    Topics: Acrylates; Angioedema; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzy

2001