lignans and Pruritus
lignans has been researched along with Pruritus* in 2 studies
Other Studies
2 other study(ies) available for lignans and Pruritus
| Article | Year |
|---|---|
Inhibitory effect of schizandrin on passive cutaneous anaphylaxis reaction and scratching behaviors in mice.
To evaluate the antiallergic effect of the fruit of Schizandra chinensis Baill (Family Magnoliaceae), which inhibited the mouse passive cutaneous anaphylaxis (PCA) reaction in a preliminary experiment, its main constituent, schizandrin, was isolated and its antiallergic effect investigated. Schizandrin inhibited the PCA reaction induced by the IgE-antigen complex, the scratching behaviors induced by compound 48/80 and the serum IgE production induced by ovalbumin. Schizandrin also inhibited the in vitro degranulation of compound 48/80-induced rat peritoneal mast cells and IgE-induced RBL 2H3 cells. Schizandrin reduced the protein expressions of TNF-alpha and IL-4 in IgE-induced RBL 2H3 cells. These findings suggest that schizandrin can improve IgE-induced anaphylaxis and scratching behaviors. Topics: Animals; Anti-Allergic Agents; Cyclooctanes; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Interleukin-4; Lignans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Molecular Structure; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Plant Extracts; Polycyclic Compounds; Pruritus; Schisandra; Tumor Necrosis Factor-alpha | 2007 |
Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors.
The antiallergic effects of magnolol and honokiol, isolated from the bark of Magnolia obovata (family Magnoliaceae), were investigated both in vitro and in vivo. Magnolol and honokiol potently inhibited passive cutaneous anaphylaxis reactions in mice induced by IgE-antigen complex as well as compound 48/80-induced scratching behaviors. These constituents exhibited not only potent inhibitory activity on the degranulation of RBL-2H3 cells induced by IgE-antigen complex, with IC(50) values of 45 and 55 muM, respectively, but also inhibited the protein expressions of IL-4 and TNF-alpha. Based on these findings, magnolol and honokiol may improve IgE-induced allergic diseases. Topics: Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Biphenyl Compounds; Cell Line, Tumor; Dose-Response Relationship, Drug; Immunoglobulin E; Inhibitory Concentration 50; Lignans; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Molecular Structure; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Pruritus; Rats | 2007 |