lignans and Ileus

Postoperative ileus is a common complication after intra-abdominal surgery. Nitric oxide produced by macrophages in the inflamed gastrointestinal tract plays a crucial role in the pathogeny of postoperative ileus. Honokiol, extracted from the bark of Magnolia spp., is a natural compound with a biphenolic structure. In the present study, we examined the effect of honokiol on postoperative ileus and discussed its site of action. Postoperative ileus model mice were generated by surgical intestinal manipulation. Mice were administered honokiol (10 mg kg

Topics: Animals; Biphenyl Compounds; Cytokines; Down-Regulation; Gastrointestinal Motility; Ileus; Inflammation Mediators; Leukocytes; Lignans; Macrophages, Peritoneal; Mice; Nitric Oxide Synthase Type II; Postoperative Complications; RNA, Messenger