lidocaine has been researched along with Pulsatile Tinnitus in 116 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An abstract in German or English and a performed intervention with lidocaine iontophoresis for the treatment of tinnitus, independent of the study design, were considered as inclusion criteria." | 9.41 | The effect of lidocaine iontophoresis for the treatment of tinnitus: a systematic review. ( Best, N; Brugger, S; Bülow, M; Derlien, S; Lemhöfer, C; Loudovici-Krug, D, 2023) |
| "Assessment of adding lidocaine to dexamethasone in the intratympanic injections for the treatment of subjective idiopathic tinnitus (SIT)." | 9.27 | Evaluation of Adding Lidocaine to Dexamethasone in the Intra-tympanic Injection for Management of Tinnitus: A Prospective, Randomized, Controlled Double-blinded Trial. ( Amer, M; Eisa, M; Elzayat, S; Mandour, MF; Mehraz, M; Ragab, S, 2018) |
| "In this prospective study, we evaluated the effectiveness of intratympanic lidocaine and dexamethasone (ITLD) injections for the management of subjective idiopathic tinnitus (SIT)." | 9.22 | Tinnitus: Evaluation of Intratympanic Injection of Combined Lidocaine and Corticosteroids. ( El-Sherif, H; El-Tahan, AR; Elzayat, S; Gabr, T; Hegazy, H, 2016) |
| "The objective of our work is to evaluate recovery induced by gabapentin alone and in association with intradermal infiltration of lidocaine in patients affected by moderate/severe tinnitus." | 9.20 | Oral gabapentin and intradermal injection of lidocaine: is there any role in the treatment of moderate/severe tinnitus? ( Bonanno, L; Cammaroto, G; Ciodaro, F; Galletti, B; Galletti, F; Mannella, VK, 2015) |
| " lidocaine has been used to ameliorate tinnitus, but in general its effect has been limited." | 9.13 | I.V. ropivacaine compared with lidocaine for the treatment of tinnitus. ( Havia, M; Kallio, H; Kentala, E; Neuvonen, PJ; Niskanen, ML; Rosenberg, PH, 2008) |
| "The effect of intravenously administered mexiletine on subjective tinnitus and hearing was studied in six patients, who initially responded positively to lidocaine." | 9.12 | The effect of intravenously administered mexiletine on tinnitus - a pilot study. ( Al-Shurbaji, A; Alván, G; Berninger, E; Idrizbegovic, E; Karlsson, KK; Meurling, L; Nordmark, J, 2006) |
| "Intravenous infusion of lidocaine has previously been demonstrated to have a transient inhibitory effect on tinnitus in 60% of individuals." | 9.11 | The inhibitory effect of intravenous lidocaine infusion on tinnitus after translabyrinthine removal of vestibular schwannoma: a double-blind, placebo-controlled, crossover study. ( Axon, PR; Baguley, DM; Jones, S; Moffat, DA; Wilkins, I, 2005) |
| "The authors conclude that intravenous lidocaine is effective in reducing intractable tinnitus and that there is a close association between lidocaine and oral carbamazepine effects." | 9.09 | Lidocaine test in patients with tinnitus: rationale of accomplishment and relation to the treatment with carbamazepine. ( Balbani, AP; Bento, RF; Bittar, RS; Câmara, J; Sanchez, TG, 1999) |
| "In the present study, evoked otoacoustic emissions (EOAEs) were measured in 30 patients with tinnitus before and after intravenous lidocaine injection (1 mg/kg)." | 9.08 | Effect of lidocaine injection of EOAE in patients with tinnitus. ( Araki, M; Haginomori, S; Kawakami, M; Makimoto, K; Takahashi, H, 1995) |
| "The efficacy of intravenous lidocaine therapy in patients suffering from severe tinnitus aurium has been reported for many years although pharmacological mechanisms for its use are not fully understood." | 9.08 | [Treatment of tinnitus with lidocaine? A report of clinical experiences]. ( Hauser, U; Hillebrandt, M; Rudack, C; Wagenmann, M, 1997) |
| "In a double-blind controlled trial in nine patients with tinnitus we measured the lidocaine plasma concentrations during and after intravenous administration of lidocaine or placebo and scored the level of tinnitus on a visual analog scale." | 9.07 | Tinnitus suppression by intravenous lidocaine in relation to its plasma concentration. ( Cohen, AF; den Hartigh, J; Hilders, CG; Hulshof, JH; Schoemaker, RC; Vermeij, P, 1993) |
| "Intravenous lidocaine was administered in 155 cases (196 ears) with tinnitus." | 9.07 | [Treatment of tinnitus with intravenous lidocaine]. ( Ueda, S, 1992) |
| "The efficacy of lidocaine and tocainide in the rational treatment of tinnitus aurium was evaluated in a double-blind randomized cross over study against saline as placebo." | 9.06 | Treatment of tinnitus with lidocaine and tocainide. ( Lenarz, T, 1986) |
| "Several recent reports have suggested that intravenous (IV) lidocaine is an effective form of therapy to relieve tinnitus; however, many of these studies were not well controlled." | 9.05 | Treatment of tinnitus with intravenous lidocaine: a double-blind randomized trial. ( Duckert, LG; Rees, TS, 1983) |
| "Available reports suggest that lidocaine is capable of relieving symptoms of tinnitus, but no convincing data support this conclusion." | 9.05 | Lidocaine in the treatment of tinnitus aurium. A double-blind study. ( Brown, J; Brummett, RE; Connelly, JS; Israel, JM; McTigue, ST, 1982) |
| "We assessed the value of tocainide in the treatment of tinnitus by performing a double-blind controlled trial in which each of 48 patients with annoying tinnitus received either tocainide HC1 900 mg/day or a placebo." | 9.05 | The value of tocainide in the treatment of tinnitus. A double-blind controlled study. ( Hulshof, JH; Vermeij, P, 1985) |
| "A double-blind controlled trial on the use of oral carbamazepine in the treatment of tinnitus is reported." | 9.05 | The value of carbamazepine in the treatment of tinnitus. ( Hulshof, JH; Vermeij, P, 1985) |
| "A randomised clinical cross-over study was performed to evaluate the therapeutic value of lidocaine, tocainide infusion and oral application of tocainide against placebo in the treatment of tinnitus." | 9.05 | [Tinnitus therapy with lidocaine and tocainide]. ( Gülzow, J; Lenarz, T, 1985) |
| "The relationship between serum lidocaine levels and tinnitus relief was assessed in 5 patients during intermittent intravenous infusions of the drug." | 9.05 | A controlled study of the suppression of tinnitus by lidocaine infusion: (relationship of therapeutic effect with serum lidocaine levels). ( Jackson, P; Perucca, E, 1985) |
| "Different routes of lidocaine administration have a good but short time effects on the tinnitus control." | 8.93 | [The value of lidocaine through different routes of administration in the treatment of tinnitus: a Meta-analysis]. ( Ji, B; Li, H; Li, M; Li, X; Tan, J; Zhang, J, 2016) |
| "To elucidate the neurological mechanism of lidocaine's suppression to tinnitus." | 7.72 | [Study of neurological mechanism of lidocaine's suppression to tinnitus via microdialysis]. ( Dong, Y; Han, HW; Li, XP; Liu, GQ; Liu, JX, 2003) |
| " We describe what we believe is the first reported case of recurrent incapacitating tinnitus secondary to inner ear tertiary syphilis in which a patient successfully responded to emergency treatment with intravenous lidocaine." | 7.72 | Lidocaine for the relief of incapacitating tinnitus. ( Consiglio, AP; Marzo, S; Stankiewicz, JA, 2004) |
| "For acute and chronic tinnitus a gradual therapeutic regimen is recommended: (1) infusions with dextrane and procaine over 5 days; (2) intravenous application of 100 mg lidocaine over 10 min; and if necessary (3) administration of glutamic diethylester and glutamic acid for 3 days." | 7.71 | [Rheologic infusion therapy, neurotransmitter administration and lidocaine injection in tinnitus. A staged therapeutic concept]. ( Agababov, V; Lenarz, T; Wilhelm, T, 2001) |
| "Intravenous administration of high doses of lidocaine has been used as a treatment modality for tinnitus." | 7.69 | [The lidocaine test in tinnitus. Determination of its current status]. ( Davis, A; Hörmann, K; Schmidt, H; Stasche, N, 1994) |
| "An auditory-evoked magnetic field was recorded before and during tinnitus remission induced by an intravenous lidocaine injection." | 7.69 | Tinnitus remission by lidocaine demonstrated by auditory-evoked magnetoencephalogram. A preliminary report. ( Fujiki, N; Hirano, S; Honjo, I; Nagamine, T; Naito, Y; Shibasaki, H; Shiomi, Y, 1997) |
| "This study was performed to examine the influence of lidocaine HCl on evoked otoacoustic emissions (EOAE) in tinnitus case." | 7.69 | [Effect of intravenous injection of lidocaine HCl on evoked otoacoustic emissions in tinnitus case]. ( Hashimoto, Y, 1997) |
| "Tocainide, an amine analogue of lidocaine, which can be taken orally, was tested on 9 patients with severe tinnitus." | 7.67 | Tocainide and tinnitus. Clinical effect and site of action. ( Larsson, B; Lyttkens, L; Wästerström, SA, 1984) |
| "To elucidate the question whether lidocaine reduces tinnitus by a central or by a peripheral mechanism of action, its effect on tinnitus was compared with that of QX-572, a quaternary ammonium derivative of lidocaine which does not readily penetrate the blood-brain barrier." | 7.67 | Local anaesthetics and tinnitus. Proposed peripheral mechanism of action of lidocaine. ( Larsson, B; Lyttkens, L; Wästerström, SA, 1984) |
| "A dose finding study was performed for the use of oral tocainide in the treatment of tinnitus." | 7.67 | Dose finding of tocainide in the treatment of tinnitus. ( Hulshof, JH; Vermeij, P, 1986) |
| "54 patients with severe tinnitus were treated by lidocaine iontophoresis." | 7.67 | [Results of tinnitus therapy using lidocaine iontophoresis]. ( Bumb, P; Welkoborsky, HJ, 1988) |
| "Intravenous lidocaine is known to have an effect on the auditory system in that it is useful for suppressing tinnitus, albeit temporarily." | 7.67 | Vestibular effects of intravenous lidocaine used in the treatment of tinnitus. ( Kirtane, MV; Merchant, SN, 1986) |
| "In the preceeding report (Jackson, 1985) the author produced evidence which brought into question the widely held view that, in abolishing tinnitus, lidocaine was acting 'centrally'." | 7.67 | Electrocochleographic findings and the effects of lidocaine on tinnitus in non-hearing ears. ( Jackson, P, 1985) |
| "Tinnitus is an otological symptom that is encountered often, yet its treatment is difficult." | 6.70 | Treatment of cochlear tinnitus with transtympanic infusion of 4% lidocaine into the tympanic cavity. ( Furuya, N; Kojima, Y; Koyama, S; Sakata, E; Sakata, H, 2001) |
| " The dosage of tocainide hydrochloride ranged from 200-600 mg daily." | 6.66 | A sequential double blind cross-over trial of tocainide hydrochloride in tinnitus. ( Blayney, AW; Colman, BH; Guy, AM; Phillips, MS, 1985) |
| "Tinnitus is defined as the perception of noise without an external acoustic stimulus." | 5.62 | Lidocaine injections to the otic ganglion for the treatment of tinnitus-A pilot study. ( Biesinger, E; Hintschich, C; Kreuzer, PM; Langguth, B; Schlee, W; Simoes, J; Strohmeyer, L; Vielsmeier, V, 2021) |
| " An abstract in German or English and a performed intervention with lidocaine iontophoresis for the treatment of tinnitus, independent of the study design, were considered as inclusion criteria." | 5.41 | The effect of lidocaine iontophoresis for the treatment of tinnitus: a systematic review. ( Best, N; Brugger, S; Bülow, M; Derlien, S; Lemhöfer, C; Loudovici-Krug, D, 2023) |
| "Tinnitus is one of the most common and distressing otological symptoms." | 5.33 | Objective evaluation of the effects of intravenous lidocaine on tinnitus. ( Bayindir, T; Erdem, T; Kalcioglu, MT; Ozturan, O, 2005) |
| "Brain imaging of tinnitus has suggested central correlates of tinnitus perception." | 5.31 | Regional cerebral blood flow during tinnitus: a PET case study with lidocaine and auditory stimulation. ( Andersson, G; Fredrikson, M; Furmark, T; Hirvelä, C; Lyttkens, L; Tillfors, M, 2000) |
| "Idiopathic subjective tinnitus (IST) is one of the most obscure otological pathologies." | 5.28 | Treatment of tinnitus by intratympanic instillation of lignocaine (lidocaine) 2 per cent through ventilation tubes. ( David, YB; Fradis, M; Podoshin, L, 1992) |
| "Assessment of adding lidocaine to dexamethasone in the intratympanic injections for the treatment of subjective idiopathic tinnitus (SIT)." | 5.27 | Evaluation of Adding Lidocaine to Dexamethasone in the Intra-tympanic Injection for Management of Tinnitus: A Prospective, Randomized, Controlled Double-blinded Trial. ( Amer, M; Eisa, M; Elzayat, S; Mandour, MF; Mehraz, M; Ragab, S, 2018) |
| "Tinnitus is an otological symptom which is often encountered and is yet difficult to treat." | 5.27 | [Therapy of tinnitus. Tympanic cavity infusion of lidocaine and steroid solution]. ( Iwashita, N; Nakazawa, H; Sakata, E, 1984) |
| "In this prospective study, we evaluated the effectiveness of intratympanic lidocaine and dexamethasone (ITLD) injections for the management of subjective idiopathic tinnitus (SIT)." | 5.22 | Tinnitus: Evaluation of Intratympanic Injection of Combined Lidocaine and Corticosteroids. ( El-Sherif, H; El-Tahan, AR; Elzayat, S; Gabr, T; Hegazy, H, 2016) |
| "The objective of our work is to evaluate recovery induced by gabapentin alone and in association with intradermal infiltration of lidocaine in patients affected by moderate/severe tinnitus." | 5.20 | Oral gabapentin and intradermal injection of lidocaine: is there any role in the treatment of moderate/severe tinnitus? ( Bonanno, L; Cammaroto, G; Ciodaro, F; Galletti, B; Galletti, F; Mannella, VK, 2015) |
| " lidocaine has been used to ameliorate tinnitus, but in general its effect has been limited." | 5.13 | I.V. ropivacaine compared with lidocaine for the treatment of tinnitus. ( Havia, M; Kallio, H; Kentala, E; Neuvonen, PJ; Niskanen, ML; Rosenberg, PH, 2008) |
| "The effect of intravenously administered mexiletine on subjective tinnitus and hearing was studied in six patients, who initially responded positively to lidocaine." | 5.12 | The effect of intravenously administered mexiletine on tinnitus - a pilot study. ( Al-Shurbaji, A; Alván, G; Berninger, E; Idrizbegovic, E; Karlsson, KK; Meurling, L; Nordmark, J, 2006) |
| "The values for tinnitus loudness, level of irritation caused by the tinnitus and subjective effectiveness of the therapy - measured by means of the visual analog scale (VAS) - showed no significant change, although the most marked improvement was indicated for caroverine." | 5.11 | [Use of the round window micro cath for inner ear therapy - results of a placebo-controlled, prospective study on chronic tinnitus]. ( Heermann, R; Lenarz, T; Schwab, B, 2004) |
| "Intravenous infusion of lidocaine has previously been demonstrated to have a transient inhibitory effect on tinnitus in 60% of individuals." | 5.11 | The inhibitory effect of intravenous lidocaine infusion on tinnitus after translabyrinthine removal of vestibular schwannoma: a double-blind, placebo-controlled, crossover study. ( Axon, PR; Baguley, DM; Jones, S; Moffat, DA; Wilkins, I, 2005) |
| "1 MPa, lidocaine injection caused only slight dizziness and buzzing in the ear." | 5.09 | Lidocaine pharmacokinetics during hyperbaric hyperoxia in humans. ( Fischer, DC; Kalff, G; Rump, AF; Siekmann, U, 1999) |
| "The authors conclude that intravenous lidocaine is effective in reducing intractable tinnitus and that there is a close association between lidocaine and oral carbamazepine effects." | 5.09 | Lidocaine test in patients with tinnitus: rationale of accomplishment and relation to the treatment with carbamazepine. ( Balbani, AP; Bento, RF; Bittar, RS; Câmara, J; Sanchez, TG, 1999) |
| "In the present study, evoked otoacoustic emissions (EOAEs) were measured in 30 patients with tinnitus before and after intravenous lidocaine injection (1 mg/kg)." | 5.08 | Effect of lidocaine injection of EOAE in patients with tinnitus. ( Araki, M; Haginomori, S; Kawakami, M; Makimoto, K; Takahashi, H, 1995) |
| "The efficacy of intravenous lidocaine therapy in patients suffering from severe tinnitus aurium has been reported for many years although pharmacological mechanisms for its use are not fully understood." | 5.08 | [Treatment of tinnitus with lidocaine? A report of clinical experiences]. ( Hauser, U; Hillebrandt, M; Rudack, C; Wagenmann, M, 1997) |
| "In a double-blind controlled trial in nine patients with tinnitus we measured the lidocaine plasma concentrations during and after intravenous administration of lidocaine or placebo and scored the level of tinnitus on a visual analog scale." | 5.07 | Tinnitus suppression by intravenous lidocaine in relation to its plasma concentration. ( Cohen, AF; den Hartigh, J; Hilders, CG; Hulshof, JH; Schoemaker, RC; Vermeij, P, 1993) |
| "Intravenous lidocaine was administered in 155 cases (196 ears) with tinnitus." | 5.07 | [Treatment of tinnitus with intravenous lidocaine]. ( Ueda, S, 1992) |
| "The efficacy of lidocaine and tocainide in the rational treatment of tinnitus aurium was evaluated in a double-blind randomized cross over study against saline as placebo." | 5.06 | Treatment of tinnitus with lidocaine and tocainide. ( Lenarz, T, 1986) |
| "Several recent reports have suggested that intravenous (IV) lidocaine is an effective form of therapy to relieve tinnitus; however, many of these studies were not well controlled." | 5.05 | Treatment of tinnitus with intravenous lidocaine: a double-blind randomized trial. ( Duckert, LG; Rees, TS, 1983) |
| "Masking devices, lidocaine, and analog oral forms of lidocaine have all been reported as being effective forms of therapy to relieve tinnitus." | 5.05 | Placebo effect in tinnitus management. ( Duckert, LG; Rees, TS, 1984) |
| " To elucidate the possible role of melanin affinity in pharmacological treatment of tinnitus and the site of action of lidocaine and tocainide, nine patients with disabling tinnitus were treated with lidocaine, QX-572 (a quaternary derivative of lidocaine which does not readily penetrate the blood-brain barrier) and tocainide (an amine analogue of lidocaine which can be taken orally)." | 5.05 | Accumulation of drugs on inner ear melanin. Therapeutic and ototoxic mechanisms. ( Wästerström, SA, 1984) |
| "Available reports suggest that lidocaine is capable of relieving symptoms of tinnitus, but no convincing data support this conclusion." | 5.05 | Lidocaine in the treatment of tinnitus aurium. A double-blind study. ( Brown, J; Brummett, RE; Connelly, JS; Israel, JM; McTigue, ST, 1982) |
| "We assessed the value of tocainide in the treatment of tinnitus by performing a double-blind controlled trial in which each of 48 patients with annoying tinnitus received either tocainide HC1 900 mg/day or a placebo." | 5.05 | The value of tocainide in the treatment of tinnitus. A double-blind controlled study. ( Hulshof, JH; Vermeij, P, 1985) |
| "A double-blind controlled trial on the use of oral carbamazepine in the treatment of tinnitus is reported." | 5.05 | The value of carbamazepine in the treatment of tinnitus. ( Hulshof, JH; Vermeij, P, 1985) |
| "A randomised clinical cross-over study was performed to evaluate the therapeutic value of lidocaine, tocainide infusion and oral application of tocainide against placebo in the treatment of tinnitus." | 5.05 | [Tinnitus therapy with lidocaine and tocainide]. ( Gülzow, J; Lenarz, T, 1985) |
| "The relationship between serum lidocaine levels and tinnitus relief was assessed in 5 patients during intermittent intravenous infusions of the drug." | 5.05 | A controlled study of the suppression of tinnitus by lidocaine infusion: (relationship of therapeutic effect with serum lidocaine levels). ( Jackson, P; Perucca, E, 1985) |
| "Different routes of lidocaine administration have a good but short time effects on the tinnitus control." | 4.93 | [The value of lidocaine through different routes of administration in the treatment of tinnitus: a Meta-analysis]. ( Ji, B; Li, H; Li, M; Li, X; Tan, J; Zhang, J, 2016) |
| "Lidocaine, a local anesthetic and anti-arrhythmic agent, is also known both as a tinnitus- and as a pain-suppressing drug." | 4.84 | Lidocaine: neurobiological targets and effects on the auditory system. ( Lautermann, J; Lehnerdt, G; Trellakis, S, 2007) |
| "Intratympanic treatment of tinnitus with corticosteroids or gentamicin should be considered as an option of treatment in selected tinnitus patients, alone or in combination with standard modalities of management such as tinnitus retraining therapy, masking, and hearing aid amplification." | 4.82 | Intratympanic perfusion for the treatment of tinnitus. ( Dodson, KM; Sismanis, A, 2004) |
| " Patients received one of two local anaesthetics (lidocaine injection or lidocaine spray) or no anaesthesia before intratympanic injection, and used a visual analogue scale to indicate the pain level after 5 and 45 minutes." | 3.83 | Effects of two different local anaesthetic methods vs no anaesthesia on pain scores for intratympanic injections. ( Ata, N; Erdur, O; Görgülü, MH; Yilmaz, E, 2016) |
| " Using a rat model of acoustic trauma-induced tinnitus, the role of the cerebellum was further examined in a series of experiments:The PFL was surgically ablated in animals with established tinnitus; the PFL was surgically ablated in animals before induction of tinnitus; the PFL was reversibly inactivated by chronic lidocaine infusion into the subarcuate fossa of animals with established tinnitus." | 3.79 | The cerebellum as a novel tinnitus generator. ( Bauer, CA; Brozoski, TJ; Kurt, W; Sybert, LT, 2013) |
| "From 2001 to 2006, we performed a retrospective study of patients suffering from chronic unilateral or bilateral tinnitus that was previously ineffectively treated by oral drugs [betahistine (Betaserc), extract of Ginkgo biloba (EGb 761), tanakan (Tebokan), and cinnarizine-dimenhydrinate (Arlevert), singly or in combination]." | 3.74 | Multimodal therapy for chronic tinnitus. ( Achiemere, G; Alpini, D; Hahn, A; Klement, V; Radkova, L; Strouhal, J, 2008) |
| "Lidocaine may lead to an alteration in the processing of hearing as observed during tinnitus by inhibiting voltage-gated potassium channels at clinically relevant concentrations." | 3.73 | Differential lidocaine sensitivity of human voltage-gated potassium channels relevant to the auditory system. ( Benzenberg, D; Friederich, P; Trellakis, S; Urban, BW, 2006) |
| "To elucidate the neurological mechanism of lidocaine's suppression to tinnitus." | 3.72 | [Study of neurological mechanism of lidocaine's suppression to tinnitus via microdialysis]. ( Dong, Y; Han, HW; Li, XP; Liu, GQ; Liu, JX, 2003) |
| " We describe what we believe is the first reported case of recurrent incapacitating tinnitus secondary to inner ear tertiary syphilis in which a patient successfully responded to emergency treatment with intravenous lidocaine." | 3.72 | Lidocaine for the relief of incapacitating tinnitus. ( Consiglio, AP; Marzo, S; Stankiewicz, JA, 2004) |
| "For acute and chronic tinnitus a gradual therapeutic regimen is recommended: (1) infusions with dextrane and procaine over 5 days; (2) intravenous application of 100 mg lidocaine over 10 min; and if necessary (3) administration of glutamic diethylester and glutamic acid for 3 days." | 3.71 | [Rheologic infusion therapy, neurotransmitter administration and lidocaine injection in tinnitus. A staged therapeutic concept]. ( Agababov, V; Lenarz, T; Wilhelm, T, 2001) |
| "The effects of lidocaine (a local anesthetic known to relieve tinnitus) in a guinea pig animal model of tinnitus in which spontaneous discharge of inferior colliculus (IC) neurons was augmented by intravenous application of salicylate (200 mg/kg) were studied by extracellular recording." | 3.70 | [Effects of lidocaine on salicylate-induced discharge of auditory neurons in the inferior colliculus of the guinea pig]. ( Manabe, Y; Saito, H; Saito, T, 1998) |
| "Intravenous administration of high doses of lidocaine has been used as a treatment modality for tinnitus." | 3.69 | [The lidocaine test in tinnitus. Determination of its current status]. ( Davis, A; Hörmann, K; Schmidt, H; Stasche, N, 1994) |
| "Since lidocaine is used to relieve the symptoms of Meniere's disease and tinnitus, its effects on the human cochlea is of specific interest." | 3.69 | Effects of intratympanically delivered lidocaine on the auditory system in humans. ( Johansson, RK; Kileny, PR; Laurikainen, EA, 1996) |
| "Using the extracellular recording method, the effects of lidocaine (a local anesthetic known to relieve tinnitus) on discharge of inferior colliculus (IC) neurons of the guinea pig were studied before and after salicylate (200 mg/kg) administration." | 3.69 | Effects of lidocaine on salicylate-induced discharge of neurons in the inferior colliculus of the guinea pig. ( Manabe, Y; Oka, H; Saito, H; Yoshida, S, 1997) |
| "An auditory-evoked magnetic field was recorded before and during tinnitus remission induced by an intravenous lidocaine injection." | 3.69 | Tinnitus remission by lidocaine demonstrated by auditory-evoked magnetoencephalogram. A preliminary report. ( Fujiki, N; Hirano, S; Honjo, I; Nagamine, T; Naito, Y; Shibasaki, H; Shiomi, Y, 1997) |
| "This study was performed to examine the influence of lidocaine HCl on evoked otoacoustic emissions (EOAE) in tinnitus case." | 3.69 | [Effect of intravenous injection of lidocaine HCl on evoked otoacoustic emissions in tinnitus case]. ( Hashimoto, Y, 1997) |
| "To determine whether tinnitus has a masking effect similar to that of general external sounds, the hearing threshold shift when the tinnitus was changed by intravenous administration of lidocaine was measured by contingent negative variation (CNV) audiometry." | 3.68 | A possible masking effect of tinnitus. Evaluation of CNV audiometry. ( Doi, T; Hosoda, Y; Kumazawa, T; Ushiro, K, 1993) |
| "Auditory evoked responses in 21 cases with tinnitus were recorded before and after the administration of intravenous lidocaine." | 3.68 | Changes in auditory evoked responses during intravenous lidocaine. ( Aso, S; Mizukoshi, K; Ueda, S; Watanabe, Y, 1993) |
| "At our department, we generally perform inner ear anesthesia with lidocaine and intratympanic dexamethasone injection for treatment of patients with Menière's disease or labyrinthine vertigo due to circulatory disturbances of the inner ear, having failed other conservative treatments." | 3.68 | Treatment of vestibular disorders. ( Itoh, A; Sakata, E, 1991) |
| "Tocainide, an amine analogue of lidocaine, which can be taken orally, was tested on 9 patients with severe tinnitus." | 3.67 | Tocainide and tinnitus. Clinical effect and site of action. ( Larsson, B; Lyttkens, L; Wästerström, SA, 1984) |
| "To elucidate the question whether lidocaine reduces tinnitus by a central or by a peripheral mechanism of action, its effect on tinnitus was compared with that of QX-572, a quaternary ammonium derivative of lidocaine which does not readily penetrate the blood-brain barrier." | 3.67 | Local anaesthetics and tinnitus. Proposed peripheral mechanism of action of lidocaine. ( Larsson, B; Lyttkens, L; Wästerström, SA, 1984) |
| "Transtympanic injection of 4% lidocaine (TTIL) is a unique procedure to treat tinnitus." | 3.67 | Influences on taste in the area of chorda tympani nerve after transtympanic injection of local anesthetic (4% lidocaine). ( Tomita, H; Yamada, Y, 1989) |
| "A dose finding study was performed for the use of oral tocainide in the treatment of tinnitus." | 3.67 | Dose finding of tocainide in the treatment of tinnitus. ( Hulshof, JH; Vermeij, P, 1986) |
| "54 patients with severe tinnitus were treated by lidocaine iontophoresis." | 3.67 | [Results of tinnitus therapy using lidocaine iontophoresis]. ( Bumb, P; Welkoborsky, HJ, 1988) |
| "Intravenous lidocaine is known to have an effect on the auditory system in that it is useful for suppressing tinnitus, albeit temporarily." | 3.67 | Vestibular effects of intravenous lidocaine used in the treatment of tinnitus. ( Kirtane, MV; Merchant, SN, 1986) |
| "In the preceeding report (Jackson, 1985) the author produced evidence which brought into question the widely held view that, in abolishing tinnitus, lidocaine was acting 'centrally'." | 3.67 | Electrocochleographic findings and the effects of lidocaine on tinnitus in non-hearing ears. ( Jackson, P, 1985) |
| "Tinnitus is an otological symptom that is encountered often, yet its treatment is difficult." | 2.70 | Treatment of cochlear tinnitus with transtympanic infusion of 4% lidocaine into the tympanic cavity. ( Furuya, N; Kojima, Y; Koyama, S; Sakata, E; Sakata, H, 2001) |
| "20 patients with sensorineural hearing loss of different kinds and a well defined tinnitus were treated by an intravenous infusion of lidocaine." | 2.66 | [Antiarrhythmic agents in tinnitus treatment]. ( Lenarz, T, 1985) |
| " The dosage of tocainide hydrochloride ranged from 200-600 mg daily." | 2.66 | A sequential double blind cross-over trial of tocainide hydrochloride in tinnitus. ( Blayney, AW; Colman, BH; Guy, AM; Phillips, MS, 1985) |
| "Chronic tinnitus affects 5-15% of the general population; in 1% of individuals with tinnitus this condition severely affects their quality of life." | 2.50 | [Pharmacotherapy for tinnitus: much ado about nothing]. ( Espinosa-Sánchez, JM; Heitzmann-Hernández, T; López-Escámez, JA, 2014) |
| "Tinnitus is the percept of sound that is not related to an acoustic source outside the body." | 2.45 | Neural activity underlying tinnitus generation: results from PET and fMRI. ( de Kleine, E; Lanting, CP; van Dijk, P, 2009) |
| "Tinnitus is an extremely prevalent condition that impinges on the lives of sufferers to varying degrees." | 2.40 | Recent advances in the pharmacological treatment of tinnitus. ( Davies, WE; Simpson, JJ, 1999) |
| "Recent research on the pharmacologic treatment of tinnitus is reviewed, emphasizing studies in which controls have been used." | 2.38 | Review of pharmacologic treatment of tinnitus. ( Harker, LA; Murai, K; Stouffer, JL; Tyler, RS, 1992) |
| "Tinnitus is defined as the perception of noise without an external acoustic stimulus." | 1.62 | Lidocaine injections to the otic ganglion for the treatment of tinnitus-A pilot study. ( Biesinger, E; Hintschich, C; Kreuzer, PM; Langguth, B; Schlee, W; Simoes, J; Strohmeyer, L; Vielsmeier, V, 2021) |
| "Tinnitus is one of the most common and distressing otological symptoms." | 1.33 | Objective evaluation of the effects of intravenous lidocaine on tinnitus. ( Bayindir, T; Erdem, T; Kalcioglu, MT; Ozturan, O, 2005) |
| "Brain imaging of tinnitus has suggested central correlates of tinnitus perception." | 1.31 | Regional cerebral blood flow during tinnitus: a PET case study with lidocaine and auditory stimulation. ( Andersson, G; Fredrikson, M; Furmark, T; Hirvelä, C; Lyttkens, L; Tillfors, M, 2000) |
| "Tinnitus is associated with a wide variety of disorders in the auditory system." | 1.30 | Positron emission tomography of cortical centers of tinnitus. ( Gjedde, A; Ishizu, K; Johannsen, P; Mirz, F; Ovesen, T; Pedersen, B; Stødkilde-Jørgensen, H, 1999) |
| "Idiopathic subjective tinnitus (IST) is one of the most obscure otological pathologies." | 1.28 | Treatment of tinnitus by intratympanic instillation of lignocaine (lidocaine) 2 per cent through ventilation tubes. ( David, YB; Fradis, M; Podoshin, L, 1992) |
| "Tinnitus is an otological symptom which is often encountered and is yet difficult to treat." | 1.27 | [Therapy of tinnitus. Tympanic cavity infusion of lidocaine and steroid solution]. ( Iwashita, N; Nakazawa, H; Sakata, E, 1984) |
| " Baseline ECochG recordings were carried out, followed by sequential recording after injections first of saline, as a control, and then after lignocaine in the dosage 1." | 1.27 | An electrocochleographic study of the effects of lignocaine on patients with tinnitus. ( Gibbin, KP; Majumdar, B; Mason, SM, 1983) |
| "Tinnitus is the subjective perception of sound that does not exist." | 1.27 | Medical treatment of tinnitus. ( Shea, JJ, 1985) |
| "Tinnitus was reduced completely or partly in 31 patients after repeated application to one or both ears." | 1.27 | [Treatment of tinnitus with iontophoresis and local anesthesia]. ( Brusis, T; Loennecken, I, 1985) |
| "Central tinnitus is defined as an abnormal sensation of sound which is perceived by the patient and established by neurotologic diagnosis to be retrocochlear and/or within the central nervous system in location." | 1.26 | Central tinnitus--diagnosis and treatment. Observations simultaneous binaural auditory brain responses with monaural stimulation in the tinnitus patient. ( Seitz, MR; Shulman, A, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (45.69) | 18.7374 |
| 1990's | 29 (25.00) | 18.2507 |
| 2000's | 24 (20.69) | 29.6817 |
| 2010's | 7 (6.03) | 24.3611 |
| 2020's | 3 (2.59) | 2.80 |
| Authors | Studies |
|---|---|
| Bülow, M | 1 |
| Best, N | 1 |
| Brugger, S | 1 |
| Derlien, S | 1 |
| Loudovici-Krug, D | 1 |
| Lemhöfer, C | 1 |
| Bertlich, M | 1 |
| Ihler, F | 1 |
| Spiegel, JL | 1 |
| Canis, M | 1 |
| Weiss, BG | 1 |
| Vielsmeier, V | 1 |
| Schlee, W | 1 |
| Langguth, B | 1 |
| Kreuzer, PM | 1 |
| Hintschich, C | 1 |
| Strohmeyer, L | 1 |
| Simoes, J | 1 |
| Biesinger, E | 1 |
| Elzayat, S | 2 |
| Ragab, S | 1 |
| Eisa, M | 1 |
| Amer, M | 1 |
| Mandour, MF | 1 |
| Mehraz, M | 1 |
| Bauer, CA | 1 |
| Kurt, W | 1 |
| Sybert, LT | 1 |
| Brozoski, TJ | 1 |
| Espinosa-Sánchez, JM | 1 |
| Heitzmann-Hernández, T | 1 |
| López-Escámez, JA | 1 |
| Ciodaro, F | 1 |
| Mannella, VK | 1 |
| Cammaroto, G | 1 |
| Bonanno, L | 1 |
| Galletti, F | 1 |
| Galletti, B | 1 |
| Li, H | 1 |
| Li, M | 1 |
| Zhang, J | 1 |
| Li, X | 1 |
| Tan, J | 1 |
| Ji, B | 1 |
| El-Sherif, H | 1 |
| Hegazy, H | 1 |
| Gabr, T | 1 |
| El-Tahan, AR | 1 |
| Ata, N | 1 |
| Erdur, O | 1 |
| Görgülü, MH | 1 |
| Yilmaz, E | 1 |
| Kallio, H | 1 |
| Niskanen, ML | 1 |
| Havia, M | 1 |
| Neuvonen, PJ | 1 |
| Rosenberg, PH | 1 |
| Kentala, E | 1 |
| Hahn, A | 1 |
| Radkova, L | 1 |
| Achiemere, G | 1 |
| Klement, V | 1 |
| Alpini, D | 1 |
| Strouhal, J | 1 |
| Adjamian, P | 1 |
| Sereda, M | 1 |
| Hall, DA | 1 |
| Lanting, CP | 1 |
| de Kleine, E | 1 |
| van Dijk, P | 1 |
| Reyes, SA | 1 |
| Salvi, RJ | 1 |
| Burkard, RF | 1 |
| Coad, ML | 1 |
| Wack, DS | 1 |
| Galantowicz, PJ | 1 |
| Lockwood, AH | 1 |
| GEJROT, T | 1 |
| Otsuka, K | 1 |
| Pulec, JL | 1 |
| Suzuki, M | 1 |
| Sakata, H | 1 |
| Kojima, Y | 1 |
| Koyama, S | 1 |
| Furuya, N | 1 |
| Sakata, E | 4 |
| Liu, JX | 1 |
| Li, XP | 1 |
| Dong, Y | 1 |
| Han, HW | 1 |
| Liu, GQ | 1 |
| Schwab, B | 2 |
| Lenarz, T | 6 |
| Heermann, R | 1 |
| Marzo, S | 1 |
| Stankiewicz, JA | 1 |
| Consiglio, AP | 1 |
| Dodson, KM | 1 |
| Sismanis, A | 1 |
| Kalcioglu, MT | 1 |
| Bayindir, T | 1 |
| Erdem, T | 1 |
| Ozturan, O | 1 |
| Rogowski, M | 2 |
| Sieśkiewicz, A | 2 |
| Rózańska-Kudelska, M | 1 |
| Walenczak, I | 1 |
| Baguley, DM | 1 |
| Jones, S | 1 |
| Wilkins, I | 1 |
| Axon, PR | 1 |
| Moffat, DA | 1 |
| Smith, PF | 1 |
| Darlington, CL | 1 |
| Trellakis, S | 2 |
| Benzenberg, D | 1 |
| Urban, BW | 1 |
| Friederich, P | 1 |
| Berninger, E | 1 |
| Nordmark, J | 1 |
| Alván, G | 1 |
| Karlsson, KK | 1 |
| Idrizbegovic, E | 1 |
| Meurling, L | 1 |
| Al-Shurbaji, A | 1 |
| Lautermann, J | 1 |
| Lehnerdt, G | 1 |
| Duckert, LG | 2 |
| Rees, TS | 2 |
| Mansbach, AL | 1 |
| Freyens, P | 1 |
| Larsson, B | 2 |
| Lyttkens, L | 4 |
| Wästerström, SA | 3 |
| Shea, JJ | 5 |
| Brand, H | 1 |
| Kuch, J | 1 |
| Lubiszewska, B | 1 |
| Nakazawa, H | 1 |
| Iwashita, N | 1 |
| Goodey, RJ | 3 |
| Cathcart, JM | 1 |
| Wood, KA | 1 |
| Webb, WL | 1 |
| Orchik, DJ | 1 |
| Majumdar, B | 1 |
| Mason, SM | 1 |
| Gibbin, KP | 1 |
| Emmett, JR | 1 |
| Martin, FW | 1 |
| Colman, BH | 2 |
| Evans, EF | 1 |
| Wilson, JP | 1 |
| Borerwe, TA | 1 |
| Israel, JM | 1 |
| Connelly, JS | 1 |
| McTigue, ST | 1 |
| Brummett, RE | 1 |
| Brown, J | 1 |
| Shulman, A | 2 |
| Seitz, MR | 1 |
| Haginomori, S | 1 |
| Makimoto, K | 1 |
| Araki, M | 1 |
| Kawakami, M | 1 |
| Takahashi, H | 1 |
| Schmidt, H | 1 |
| Davis, A | 1 |
| Stasche, N | 1 |
| Hörmann, K | 1 |
| den Hartigh, J | 1 |
| Hilders, CG | 1 |
| Schoemaker, RC | 1 |
| Hulshof, JH | 5 |
| Cohen, AF | 1 |
| Vermeij, P | 5 |
| Colonna-Romano, P | 1 |
| Lingaraju, N | 1 |
| Braitman, LE | 1 |
| Bjorne, A | 1 |
| Hosoda, Y | 1 |
| Ushiro, K | 1 |
| Doi, T | 1 |
| Kumazawa, T | 1 |
| Strebel, S | 1 |
| Frei, F | 1 |
| Rosow, CE | 1 |
| Drewe, J | 1 |
| Ueda, S | 2 |
| Aso, S | 1 |
| Watanabe, Y | 1 |
| Mizukoshi, K | 1 |
| Laurikainen, EA | 1 |
| Johansson, RK | 1 |
| Kileny, PR | 1 |
| Manabe, Y | 2 |
| Yoshida, S | 1 |
| Saito, H | 2 |
| Oka, H | 1 |
| Shiomi, Y | 1 |
| Nagamine, T | 1 |
| Fujiki, N | 1 |
| Hirano, S | 1 |
| Naito, Y | 1 |
| Shibasaki, H | 1 |
| Honjo, I | 1 |
| Kellerhals, B | 2 |
| Rudack, C | 1 |
| Hillebrandt, M | 1 |
| Wagenmann, M | 1 |
| Hauser, U | 1 |
| Hashimoto, Y | 1 |
| Rosanowski, F | 1 |
| Hoppe, U | 1 |
| Pröschel, U | 1 |
| Eysholdt, U | 1 |
| Saito, T | 1 |
| Cazals, Y | 1 |
| Horner, KC | 1 |
| Huang, ZW | 1 |
| Simpson, JJ | 1 |
| Davies, WE | 1 |
| Rump, AF | 1 |
| Siekmann, U | 1 |
| Fischer, DC | 1 |
| Kalff, G | 1 |
| Mirz, F | 1 |
| Pedersen, B | 1 |
| Ishizu, K | 1 |
| Johannsen, P | 1 |
| Ovesen, T | 1 |
| Stødkilde-Jørgensen, H | 1 |
| Gjedde, A | 1 |
| Sanchez, TG | 1 |
| Balbani, AP | 1 |
| Bittar, RS | 1 |
| Bento, RF | 1 |
| Câmara, J | 1 |
| Gindzieńska, E | 1 |
| Andersson, G | 1 |
| Hirvelä, C | 1 |
| Furmark, T | 1 |
| Tillfors, M | 1 |
| Fredrikson, M | 1 |
| Wilhelm, T | 1 |
| Agababov, V | 1 |
| Howard, ML | 1 |
| Hazell, JW | 1 |
| Melding, PS | 2 |
| Thorne, PR | 1 |
| Harell, M | 1 |
| Umeda, Y | 1 |
| Takahashi, K | 1 |
| Ohtsu, K | 1 |
| Murai, K | 1 |
| Tyler, RS | 1 |
| Harker, LA | 1 |
| Stouffer, JL | 1 |
| Coles, RR | 1 |
| Thompson, AC | 1 |
| O'Donoghue, GM | 1 |
| Podoshin, L | 1 |
| Fradis, M | 1 |
| David, YB | 1 |
| Guth, PS | 2 |
| Risey, J | 1 |
| Briner, W | 1 |
| Blair, P | 1 |
| Reed, HT | 2 |
| Bryant, G | 1 |
| Norris, C | 1 |
| Housley, G | 1 |
| Miller, R | 1 |
| Itoh, A | 1 |
| Sejna, I | 1 |
| Marik, E | 1 |
| Sauer, H | 1 |
| Meltzer, J | 1 |
| Crews, P | 1 |
| Norris, CH | 1 |
| Quine, DB | 1 |
| Yamada, Y | 1 |
| Tomita, H | 1 |
| Laffrée, JB | 1 |
| Yamanaka, E | 1 |
| Gyo, K | 1 |
| Saiki, T | 1 |
| Yanagihara, N | 1 |
| Schönweiler, R | 2 |
| Welkoborsky, HJ | 1 |
| Bumb, P | 1 |
| Balkany, T | 1 |
| Bantli, H | 1 |
| Vernon, J | 1 |
| Douek, E | 1 |
| House, J | 1 |
| Portmann, M | 1 |
| House, W | 1 |
| Merchant, SN | 2 |
| Kirtane, MV | 1 |
| Blayney, AW | 1 |
| Phillips, MS | 1 |
| Guy, AM | 1 |
| Gülzow, J | 1 |
| Perucca, E | 1 |
| Jackson, P | 3 |
| Brusis, T | 1 |
| Loennecken, I | 1 |
| Merchant, N | 1 |
| Ruth, RA | 1 |
| Gal, TJ | 1 |
| DiFazio, CA | 1 |
| Moscicki, JC | 1 |
| Smith, CA | 1 |
| Steinhaus, JE | 1 |
| Haynes, CD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Adding Lidocaine to Dexamethasone in Intra-tympanic Injection for Management of Tinnitus[NCT03265197] | Phase 1 | 44 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Transcranial Modulation of Oscillatory Brain Activity in People With Tinnitus: A Concurrent Transcranial Direct Current Stimulation (tDCS) - Magnetoencephalography (MEG) Study[NCT04978142] | 40 participants (Actual) | Interventional | 2020-12-07 | Completed | |||
| Treatment of Tinnitus With Migraine Medications: A Randomized Clinical Trial[NCT04404439] | Phase 4 | 150 participants (Anticipated) | Interventional | 2019-09-26 | Recruiting | ||
| Nitrous Oxide as Treatment for Tinnitus: A Randomized Crossover Trial[NCT03365011] | Phase 4 | 40 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change of participant-reported tinnitus symptoms 1 week after each intervention.~The Tinnitus Functional Index (TFI) is a 25-question survey assessing tinnitus impact on quality of life. Participants were asked to rate on a scale from 0-10 the degree of unpleasantness, cognitive interference, sleep disturbance, auditory difficulties, interference with relaxation, and emotional distress associated with their tinnitus. Subscores are summed and scaled to a score of 0-100. A score less than 25 indicates mild problems due to tinnitus and little need for intervention, while a score between 25-50 indicates significant problems due to tinnitus with potential need for intervention.~A decrease in TFI score indicates decreased bother due to tinnitus over time, a better outcome. An increase in TFI score indicates increased bother due to tinnitus over time, a worse outcome." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | -1.8 |
| Nitrous Oxide | -2.5 |
"Change in participant-reported tinnitus bother after each intervention.~Global Bothersome Scale (GBS) measured participant's self-assessment of tinnitus bother on a 5-point scale ranging from Not bothered, 0 to Extremely bothered, 5.~A change of 0 indicates no change in tinnitus bother over time. A change of -1 indicates somewhat improved tinnitus bother, and a change of positive 1 indicates somewhat worsened tinnitus bother. A change of positive 2 indicates significantly worsened tinnitus bother." (NCT03365011)
Timeframe: Pre-intervention and 1 week post-intervention
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Somewhat improved, -1 | No change, 0 | Somewhat worsened, 1 | Significantly worsened, 2 | |
| Nitrous Oxide | 2 | 34 | 2 | 0 |
| Placebo | 5 | 28 | 5 | 1 |
14 reviews available for lidocaine and Pulsatile Tinnitus
| Article | Year |
|---|---|
The effect of lidocaine iontophoresis for the treatment of tinnitus: a systematic review.
Topics: Cochlea; Humans; Iontophoresis; Lidocaine; Research Design; Tinnitus | 2023 |
[Pharmacotherapy for tinnitus: much ado about nothing].
Topics: Adrenal Cortex Hormones; Anesthetics, Local; Anticonvulsants; Antidepressive Agents; Auditory Pathwa | 2014 |
[The value of lidocaine through different routes of administration in the treatment of tinnitus: a Meta-analysis].
Topics: Humans; Lidocaine; Tinnitus | 2016 |
The mechanisms of tinnitus: perspectives from human functional neuroimaging.
Topics: Action Potentials; Animals; Auditory Cortex; Disease Models, Animal; Electroencephalography; Electro | 2009 |
Neural activity underlying tinnitus generation: results from PET and fMRI.
Topics: Acoustic Stimulation; Auditory Cortex; Auditory Pathways; Eye Movements; Female; Humans; Lidocaine; | 2009 |
Intratympanic perfusion for the treatment of tinnitus.
Topics: Administration, Topical; Anesthetics, Local; Anti-Bacterial Agents; Gentamicins; Glucocorticoids; Hu | 2004 |
Drug treatments for subjective tinnitus: serendipitous discovery versus rational drug design.
Topics: Anticonvulsants; Drug Design; Gentamicins; Humans; Lidocaine; Tinnitus; Treatment Outcome | 2005 |
Lidocaine: neurobiological targets and effects on the auditory system.
Topics: Anesthetics, Local; Animals; Auditory Pathways; Humans; Ion Channels; Lidocaine; Tinnitus | 2007 |
Medical treatment of tinnitus.
Topics: Amitriptyline; Anti-Arrhythmia Agents; Auditory Pathways; Drug Combinations; Humans; Lidocaine; Pain | 1984 |
Animal models of tinnitus.
Topics: Acoustic Stimulation; Action Potentials; Aged; Animals; Cats; Cochlear Nerve; Disease Models, Animal | 1981 |
Recent advances in the pharmacological treatment of tinnitus.
Topics: Anti-Anxiety Agents; Anticonvulsants; Clinical Trials as Topic; Counseling; Humans; Hypnotics and Se | 1999 |
Tinnitus.
Topics: Aspirin; Carbamazepine; Ear Diseases; Electric Stimulation Therapy; Hearing Loss, Noise-Induced; Hum | 1979 |
Review of pharmacologic treatment of tinnitus.
Topics: Antidepressive Agents; Antipsychotic Agents; Carbamazepine; Double-Blind Method; Female; Flunarizine | 1992 |
Pharmacological treatment of tinnitus with special reference to the role of melanin.
Topics: Ear, Inner; Humans; Lidocaine; Melanins; Tinnitus | 1986 |
34 trials available for lidocaine and Pulsatile Tinnitus
| Article | Year |
|---|---|
Evaluation of Adding Lidocaine to Dexamethasone in the Intra-tympanic Injection for Management of Tinnitus: A Prospective, Randomized, Controlled Double-blinded Trial.
Topics: Anesthetics, Local; Dexamethasone; Double-Blind Method; Glucocorticoids; Humans; Injection, Intratym | 2018 |
Oral gabapentin and intradermal injection of lidocaine: is there any role in the treatment of moderate/severe tinnitus?
Topics: Administration, Oral; Adult; Amines; Anesthetics, Local; Anticonvulsants; Cyclohexanecarboxylic Acid | 2015 |
Tinnitus: Evaluation of Intratympanic Injection of Combined Lidocaine and Corticosteroids.
Topics: Adult; Anesthetics, Local; Audiometry; Dexamethasone; Double-Blind Method; Drug Therapy, Combination | 2016 |
I.V. ropivacaine compared with lidocaine for the treatment of tinnitus.
Topics: Adult; Aged; Amides; Anesthetics, Local; Cross-Over Studies; Double-Blind Method; Drug Administratio | 2008 |
Brain imaging of the effects of lidocaine on tinnitus.
Topics: Acoustic Stimulation; Adult; Aged; Auditory Cortex; Auditory Pathways; Cerebrovascular Circulation; | 2002 |
Assessment of intravenous lidocaine for the treatment of subjective tinnitus.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Female; Humans; Lidocai | 2003 |
Treatment of cochlear tinnitus with transtympanic infusion of 4% lidocaine into the tympanic cavity.
Topics: Anesthetics, Local; Ear, Inner; Ear, Middle; Female; Humans; Infusions, Parenteral; Lidocaine; Male; | 2001 |
[Use of the round window micro cath for inner ear therapy - results of a placebo-controlled, prospective study on chronic tinnitus].
Topics: Administration, Topical; Adult; Aged; Auditory Threshold; Catheters, Indwelling; Chronic Disease; Ea | 2004 |
The inhibitory effect of intravenous lidocaine infusion on tinnitus after translabyrinthine removal of vestibular schwannoma: a double-blind, placebo-controlled, crossover study.
Topics: Adult; Aged; Cross-Over Studies; Double-Blind Method; Ear, Inner; Female; Humans; Lidocaine; Male; M | 2005 |
The effect of intravenously administered mexiletine on tinnitus - a pilot study.
Topics: Adult; Anesthetics, Local; Anti-Arrhythmia Agents; Female; Humans; Injections, Intravenous; Lidocain | 2006 |
Treatment of tinnitus with intravenous lidocaine: a double-blind randomized trial.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infusions, Parenteral; L | 1983 |
Placebo effect in tinnitus management.
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Lidocaine; Placebos; Research Design; Tinnitu | 1984 |
Accumulation of drugs on inner ear melanin. Therapeutic and ototoxic mechanisms.
Topics: Adult; Anesthetics, Local; Animals; Auditory Threshold; Brain Stem; Clinical Trials as Topic; Double | 1984 |
Assessment of the value of tocainide hydrochloride in the treatment of tinnitus.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle | 1982 |
Tinnitus: a double-blind crossover controlled trial to evaluate the use of lignocaine.
Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle | 1980 |
Lidocaine in the treatment of tinnitus aurium. A double-blind study.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Injections, Intravenous; Lidocaine; M | 1982 |
Effect of lidocaine injection of EOAE in patients with tinnitus.
Topics: Acoustic Stimulation; Adult; Aged; Anesthetics, Local; Audiometry, Pure-Tone; Auditory Pathways; Coc | 1995 |
Tinnitus suppression by intravenous lidocaine in relation to its plasma concentration.
Topics: Adult; Aged; Analysis of Variance; Double-Blind Method; Female; Humans; Infusions, Intravenous; Lido | 1993 |
Epidural test dose: lidocaine 100 mg, not chloroprocaine, is a symptomatic marker of i.v. injection in labouring parturients.
Topics: Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics, Local; Dizziness; Double-Blind Method; F | 1993 |
Central nervous system symptoms after intravenous lignocaine: dose-response during pregnancy.
Topics: Abortion, Therapeutic; Anesthesia, Intravenous; Anesthesia, Obstetrical; Brain; Catheterization, Per | 1993 |
[Treatment of tinnitus with lidocaine? A report of clinical experiences].
Topics: Administration, Oral; Anesthetics, Local; Dose-Response Relationship, Drug; Humans; Infusions, Intra | 1997 |
Lidocaine pharmacokinetics during hyperbaric hyperoxia in humans.
Topics: Adult; Anticonvulsants; Cross-Over Studies; Decompression Sickness; Dizziness; Drug Monitoring; Huma | 1999 |
Lidocaine test in patients with tinnitus: rationale of accomplishment and relation to the treatment with carbamazepine.
Topics: Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Anesthetics, Local; Carbamazepine; Fema | 1999 |
[Treatment of tinnitus with intravenous lidocaine].
Topics: Adult; Aged; Double-Blind Method; Female; Hearing; Humans; Injections, Intravenous; Lidocaine; Male; | 1992 |
Evaluation of amino-oxyacetic acid as a palliative in tinnitus.
Topics: Acetates; Aminooxyacetic Acid; Audiometry; Clinical Trials as Topic; Female; Humans; Lidocaine; Pall | 1990 |
Amino-oxyacetic acid as a palliative in tinnitus.
Topics: Acetates; Aminooxyacetic Acid; Clinical Trials as Topic; Double-Blind Method; Female; Hearing Disord | 1985 |
The effect of iontophoresis of lignocaine in the treatment of tinnitus.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Iontophoresis; Lidocaine; Male; Middle Aged; Rando | 1989 |
Treatment of tinnitus with lidocaine and tocainide.
Topics: Administration, Oral; Animals; Clinical Trials as Topic; Double-Blind Method; Evoked Potentials, Aud | 1986 |
The value of tocainide in the treatment of tinnitus. A double-blind controlled study.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Clinical Trials as Topic; Double-Blind Method; Drug Eruptions; | 1985 |
[Antiarrhythmic agents in tinnitus treatment].
Topics: Clinical Trials as Topic; Hearing Loss, Sensorineural; Humans; Infusions, Parenteral; Lidocaine; Tin | 1985 |
The value of carbamazepine in the treatment of tinnitus.
Topics: Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Humans; Lidocaine; Middle | 1985 |
A sequential double blind cross-over trial of tocainide hydrochloride in tinnitus.
Topics: Adult; Aged; Clinical Trials as Topic; Dizziness; Double-Blind Method; Headache; Humans; Lidocaine; | 1985 |
[Tinnitus therapy with lidocaine and tocainide].
Topics: Administration, Oral; Auditory Threshold; Clinical Trials as Topic; Dose-Response Relationship, Drug | 1985 |
A controlled study of the suppression of tinnitus by lidocaine infusion: (relationship of therapeutic effect with serum lidocaine levels).
Topics: Adult; Aged; Female; Humans; Infusions, Parenteral; Lidocaine; Middle Aged; Tinnitus | 1985 |
68 other studies available for lidocaine and Pulsatile Tinnitus
| Article | Year |
|---|---|
Intratympanal administration of lidocaine in the management of Ménière's Disease.
Topics: Auditory Threshold; Female; Follow-Up Studies; Hearing Loss; Humans; Injection, Intratympanic; Lidoc | 2021 |
Lidocaine injections to the otic ganglion for the treatment of tinnitus-A pilot study.
Topics: Germany; Humans; Lidocaine; Pilot Projects; Tinnitus; Treatment Outcome | 2021 |
The cerebellum as a novel tinnitus generator.
Topics: Animals; Auditory Perception; Auditory Threshold; Cerebellum; Disease Models, Animal; Hearing Loss, | 2013 |
Effects of two different local anaesthetic methods vs no anaesthesia on pain scores for intratympanic injections.
Topics: Administration, Topical; Adolescent; Adult; Aged; Anesthetics, Local; Dexamethasone; Female; Glucoco | 2016 |
Multimodal therapy for chronic tinnitus.
Topics: Adult; Aged; Betahistine; Chronic Disease; Cinnarizine; Combined Modality Therapy; Dimenhydrinate; D | 2008 |
INTRAVENOUS XYLOCAINE IN THE TREATMENT OF ATTACKS OF MENI'ERE'S DISEASE.
Topics: Humans; Injections, Intravenous; Lidocaine; Meniere Disease; Motion Sickness; Nausea; Nystagmus, Pat | 1964 |
[Study of neurological mechanism of lidocaine's suppression to tinnitus via microdialysis].
Topics: Animals; Hypothalamus; Lidocaine; Microdialysis; Random Allocation; Rats; Rats, Wistar; Salicylic Ac | 2003 |
[Cardiac rhythm disturbances by lidocaine therapy for tinnitus].
Topics: Anesthetics, Local; Arrhythmias, Cardiac; Electrocardiography; Electroencephalography; Humans; Injec | 2004 |
Lidocaine for the relief of incapacitating tinnitus.
Topics: Diagnosis, Differential; Emergency Treatment; Female; Humans; Infusions, Intravenous; Lidocaine; Mid | 2004 |
Objective evaluation of the effects of intravenous lidocaine on tinnitus.
Topics: Acoustic Impedance Tests; Adult; Anesthetics, Local; Audiometry, Pure-Tone; Female; Humans; Infusion | 2005 |
[Some aspects of pharmacotherapy of tinnitus. Compound therapy with Xylocaine and directive counseling--long-term results].
Topics: Anesthetics, Local; Audiometry, Pure-Tone; Counseling; Humans; Lidocaine; Outcome Assessment, Health | 2004 |
Differential lidocaine sensitivity of human voltage-gated potassium channels relevant to the auditory system.
Topics: Anesthetics, Local; Cell Culture Techniques; Cell Line; Hearing Loss; Humans; Lidocaine; Patch-Clamp | 2006 |
[Tinnitus: current data and treatment with sodium valproate].
Topics: Adult; Aged; Drug Evaluation; Female; Hair Cells, Auditory; Hair Cells, Auditory, Inner; Humans; Hyp | 1983 |
Tocainide and tinnitus. Clinical effect and site of action.
Topics: Animals; Chemical Phenomena; Chemistry; Ear, Inner; Humans; In Vitro Techniques; Lidocaine; Male; Me | 1984 |
Tinnitus: treatment methods and results.
Topics: Adult; Aged; Anticonvulsants; Benzodiazepines; Cochlear Nerve; Female; Humans; Labyrinth Diseases; L | 1984 |
[Neural therapy in tinnitus].
Topics: Acupuncture Therapy; Humans; Lidocaine; Male; Tinnitus | 1983 |
[Effectiveness and tolerance of "Lignocainum hydrochloricum" in the treatment of arrhythmia in ischemic heart disease].
Topics: Adult; Aged; Arrhythmias, Cardiac; Coronary Disease; Humans; Hypotension; Lidocaine; Middle Aged; Ti | 1983 |
Local anaesthetics and tinnitus. Proposed peripheral mechanism of action of lidocaine.
Topics: Animals; Chemical Phenomena; Chemistry; Double-Blind Method; Ear, Inner; Humans; In Vitro Techniques | 1984 |
[Therapy of tinnitus. Tympanic cavity infusion of lidocaine and steroid solution].
Topics: Dexamethasone; Ear, Middle; Humans; Hyperacusis; Lidocaine; Tinnitus | 1984 |
Drugs in the treatment of tinnitus.
Topics: Amobarbital; Antidepressive Agents, Tricyclic; Carbamazepine; Ethanol; Humans; Lidocaine; Phenytoin; | 1981 |
Intractable tinnitus: psychiatric aspects of treatment.
Topics: Adult; Affective Symptoms; Extraversion, Psychological; Female; Humans; Lidocaine; Male; Middle Aged | 1983 |
An electrocochleographic study of the effects of lignocaine on patients with tinnitus.
Topics: Adult; Aged; Audiometry; Audiometry, Evoked Response; Cochlea; Female; Humans; Labyrinth Diseases; L | 1983 |
The medical treatment of tinnitus.
Topics: Adult; Carbamazepine; Diethylcarbamazine; Female; Humans; Lidocaine; Myoclonus; Phenytoin; Primidone | 1981 |
Central tinnitus--diagnosis and treatment. Observations simultaneous binaural auditory brain responses with monaural stimulation in the tinnitus patient.
Topics: Audiometry; Audiometry, Evoked Response; Brain Stem; Evoked Potentials, Auditory; Humans; Lidocaine; | 1981 |
[The lidocaine test in tinnitus. Determination of its current status].
Topics: Administration, Oral; Adult; Aged; Auditory Threshold; Chronic Disease; Diazepam; Dose-Response Rela | 1994 |
Tinnitus aureum as an effect of increased tension in the lateral pterygoid muscle.
Topics: Adult; Aged; Craniomandibular Disorders; Female; Humans; Injections, Intramuscular; Lidocaine; Male; | 1993 |
A possible masking effect of tinnitus. Evaluation of CNV audiometry.
Topics: Audiometry, Evoked Response; Auditory Threshold; Cerebral Cortex; Contingent Negative Variation; Hum | 1993 |
Changes in auditory evoked responses during intravenous lidocaine.
Topics: Audiometry, Evoked Response; Brain Stem; Cochlear Nerve; Evoked Potentials, Auditory, Brain Stem; Fe | 1993 |
Effects of intratympanically delivered lidocaine on the auditory system in humans.
Topics: Acoustic Stimulation; Adult; Anesthetics, Local; Audiometry, Pure-Tone; Auditory Threshold; Cochlea; | 1996 |
Effects of lidocaine on salicylate-induced discharge of neurons in the inferior colliculus of the guinea pig.
Topics: Action Potentials; Anesthetics, Local; Animals; Auditory Pathways; Disease Models, Animal; Electroph | 1997 |
Tinnitus remission by lidocaine demonstrated by auditory-evoked magnetoencephalogram. A preliminary report.
Topics: Aged; Anesthetics, Local; Evoked Potentials, Auditory; Female; Functional Laterality; Humans; Lidoca | 1997 |
[Treatment of tinnitus with lidocaine?].
Topics: Anesthetics, Local; Dose-Response Relationship, Drug; Humans; Lidocaine; Tinnitus; Treatment Outcome | 1997 |
[Effect of intravenous injection of lidocaine HCl on evoked otoacoustic emissions in tinnitus case].
Topics: Acoustic Stimulation; Adult; Aged; Evoked Potentials, Auditory; Female; Humans; Injections, Intraven | 1997 |
[Chronic tinnitus in children and adolescents].
Topics: Adolescent; Age Factors; Audiometry, Pure-Tone; Audiometry, Speech; Child; Chronic Disease; Counseli | 1997 |
[Effects of lidocaine on salicylate-induced discharge of auditory neurons in the inferior colliculus of the guinea pig].
Topics: Action Potentials; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Infer | 1998 |
Alterations in average spectrum of cochleoneural activity by long-term salicylate treatment in the guinea pig: a plausible index of tinnitus.
Topics: Acoustic Stimulation; Action Potentials; Animals; Cochlear Nerve; Electrophysiology; Guinea Pigs; Li | 1998 |
Positron emission tomography of cortical centers of tinnitus.
Topics: Adult; Brain Mapping; Cerebral Cortex; Cerebrovascular Circulation; Female; Humans; Injections, Intr | 1999 |
[Transient evoked otoacoustic emissions (TEOAE) in tinnitus patients treated with xylocaine].
Topics: Adult; Aged; Anesthetics, Local; Dose-Response Relationship, Drug; Humans; Lidocaine; Middle Aged; O | 2000 |
Regional cerebral blood flow during tinnitus: a PET case study with lidocaine and auditory stimulation.
Topics: Acoustic Stimulation; Anesthetics, Local; Cerebrovascular Circulation; Female; Humans; Lidocaine; Mi | 2000 |
[Rheologic infusion therapy, neurotransmitter administration and lidocaine injection in tinnitus. A staged therapeutic concept].
Topics: Adolescent; Adult; Aged; Cochlea; Dextrans; Drug Therapy, Combination; Female; Follow-Up Studies; Gl | 2001 |
Myths in neurotology, revisited: smoke and mirrors in tinnitus therapy.
Topics: Acupuncture Therapy; Anesthetics, Local; Biofeedback, Psychology; Ginkgo biloba; History, 16th Centu | 2001 |
[Expanding the view].
Topics: Chronic Disease; Clinical Trials as Topic; Combined Modality Therapy; Counseling; Hemodilution; Huma | 2001 |
The treatment of tinnitus with oral anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Carbamazepine; Female; Humans; Lidocaine; Male; Middle Aged; Phen | 1979 |
The use of intravenous lignocaine in the diagnosis and treatment of tinnitus.
Topics: Auditory Threshold; Deafness; Humans; Lidocaine; Tinnitus | 1978 |
Management of tinnitus aurium with lidocaine and carbamazepine.
Topics: Administration, Oral; Adult; Aged; Carbamazepine; Drug Evaluation; Female; Humans; Injections, Intra | 1978 |
[Treatment of the cochlear tinnitus--blocking therapy with 4% lidocaine-- (author's transl)].
Topics: Adolescent; Adult; Female; Humans; Lidocaine; Male; Middle Aged; Nerve Block; Tinnitus | 1976 |
Intra-tympanic injections in the treatment of tinnitus.
Topics: Adult; Aged; Dexamethasone; Female; Follow-Up Studies; Humans; Injections, Intralesional; Lidocaine; | 1992 |
Treatment of tinnitus by intratympanic instillation of lignocaine (lidocaine) 2 per cent through ventilation tubes.
Topics: Adult; Aged; Female; Humans; Injections; Instillation, Drug; Lidocaine; Male; Middle Aged; Middle Ea | 1992 |
Treatment of vestibular disorders.
Topics: Anesthesia; Audiometry; Dexamethasone; Ear, Inner; Ear, Middle; Female; Hearing; Humans; Injections; | 1991 |
[Treatment of tinnitus by Neolidocatone administered by iontophoresis into the middle ear].
Topics: Ear, Middle; Humans; Iontophoresis; Lidocaine; Tinnitus | 1990 |
[Adjuvant alternative therapy procedures in idiopathic tinnitus aurium (and in sudden deafness)].
Topics: Acupuncture Therapy; Caloric Tests; Combined Modality Therapy; Hearing Loss, Sudden; Humans; Injecti | 1990 |
Influences on taste in the area of chorda tympani nerve after transtympanic injection of local anesthetic (4% lidocaine).
Topics: Adult; Aged; Chorda Tympani Nerve; Dexamethasone; Female; Humans; Iontophoresis; Lidocaine; Male; Mi | 1989 |
[The effect of intravenous administration of xylocaine for the treatment of tinnitus].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Drug Evaluation; Female; Humans; Injections, Intr | 1989 |
Dose finding of tocainide in the treatment of tinnitus.
Topics: Administration, Oral; Adult; Aged; Drug Evaluation; Female; Humans; Kinetics; Lidocaine; Male; Middl | 1986 |
[Therapy of severe tinnitus. A report of experiences].
Topics: Adult; Aged; Female; Humans; Infusion Pumps; Iontophoresis; Lidocaine; Male; Middle Aged; Tinnitus; | 1987 |
[Results of tinnitus therapy using lidocaine iontophoresis].
Topics: Adolescent; Adult; Aged; Audiometry; Caloric Tests; Female; Humans; Iontophoresis; Lidocaine; Male; | 1988 |
Workshop: direct electrical stimulation of the inner ear for the relief of tinnitus.
Topics: Animals; Cochlea; Cochlear Implants; Ear, Inner; Electric Stimulation Therapy; Electrodes; Female; G | 1987 |
[Tinnitus: causes, diagnosis and therapy].
Topics: Acoustic Impedance Tests; Acupuncture Therapy; Audiometry; Electric Stimulation; Electromagnetic Fie | 1986 |
Vestibular effects of intravenous lidocaine used in the treatment of tinnitus.
Topics: Electronystagmography; Humans; Injections, Intravenous; Lidocaine; Tinnitus; Vestibular Function Tes | 1986 |
Medical treatment of tinnitus.
Topics: Humans; Lidocaine; Tinnitus; Tocainide | 1985 |
Treatment for tinnitus.
Topics: Electric Stimulation; Hearing Aids; Humans; Lidocaine; Tinnitus | 1985 |
A comparison of the effects of eighth nerve section with lidocaine on tinnitus.
Topics: Adult; Female; Humans; Lidocaine; Male; Middle Aged; Tinnitus; Vestibulocochlear Nerve | 1985 |
Electrocochleographic findings and the effects of lidocaine on tinnitus in non-hearing ears.
Topics: Adult; Audiometry, Evoked Response; Deafness; Female; Humans; Lidocaine; Male; Middle Aged; Tinnitus | 1985 |
[Treatment of tinnitus with iontophoresis and local anesthesia].
Topics: Adolescent; Adult; Aged; Anesthesia, Local; Audiometry, Pure-Tone; Female; Humans; Iontophoresis; Li | 1985 |
Intravenous lignocaine in tinnitus.
Topics: Adult; Aged; Female; Humans; Injections, Intravenous; Lidocaine; Male; Middle Aged; Tinnitus | 1985 |
Brain-stem auditory-evoked potentials during lidocaine infusion in humans.
Topics: Acoustic Stimulation; Adult; Brain Stem; Evoked Potentials, Auditory; Humans; Infusions, Parenteral; | 1985 |
Lidocaine (Xylocaine) as an anti-arrhythmic agent.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Electrocardiography; Hea | 1971 |
The safety and effectiveness of intravenous regional anesthesia.
Topics: Anesthesia, Conduction; Anesthesia, Intravenous; Blood Pressure; Central Nervous System; Electrocard | 1968 |