leuprolide has been researched along with Edema* in 2 studies
1 trial(s) available for leuprolide and Edema
| Article | Year |
|---|---|
Menopausal changes in the myometrium: an investigation using a GnRH agonist model.
Thirty-four premenopausal women were randomized to receive 3.75 mg of leuprorelin acetate depot or placebo for 8 weeks before hysterectomy. Postoperatively, the myometrium was examined by two independent pathologists and the pathologic features were graded. Computer analysis was used to assess myometrial cellularity and arterial wall structure (on hematoxylin and eosin-stained sections) and vascularity (on sections immunostained for Factor VIII-related antigen). The cellularity of the gonadotrophin-releasing hormone agonist-treated myometrium was higher than the controls with less stromal edema. Focal myometrial hyalinization was present in a minority of cases, all in the gonadotrophin-releasing hormone agonist-treated cases. The arteries in the gonadotrophin-releasing hormone agonist-treated uteri underwent atrophy of the tunica media and had significantly more perivascular fibrosis. The number of vessels per 100 myocytes also was decreased. Hypoestrinism secondary to leuprorelin treatment leads to myocyte atrophy, decreased stromal edema, atrophy of the arcuate arteries, and decreased myometrial vascularity. Topics: Arteries; Atrophy; Delayed-Action Preparations; Double-Blind Method; Edema; Estradiol; Female; Fibrosis; Humans; Leuprolide; Menopause; Models, Biological; Myometrium; Placebos; Stromal Cells | 1999 |
1 other study(ies) available for leuprolide and Edema
| Article | Year |
|---|---|
Postparacentesis bilateral massive vulvar edema in a patient with severe ovarian hyperstimulation syndrome.
To report a case of bilateral massive vulvar edema following lower abdominal paracentesis in a patient with ovarian hyperstimulation syndrome.. Case report.. University teaching hospital.. A 32-year-old woman with primary infertility.. The patient underwent ovarian stimulation with leuprolide acetate, highly purified FSH, and hCG. Because of the development of severe ovarian hyperstimulation syndrome, bilateral paracentesis through the lower abdominal quadrants was performed.. Treatment of ovarian hyperstimulation syndrome.. Development of bilateral massive vulvar edema 24 hours after lower abdominal paracentesis.. This case report suggests that lower abdominal paracentesis could be the cause of vulvar edema development in ovarian hyperstimulation syndrome, probably due to a fistulous tract created between the peritoneal cavity and the subcutaneous tissues. Topics: Adult; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Edema; Female; Follicle Stimulating Hormone; Humans; Leuprolide; Ovarian Hyperstimulation Syndrome; Ovulation Induction; Paracentesis; Vulvar Diseases | 2002 |