leucine has been researched along with Sepsis in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (16.22) | 18.7374 |
| 1990's | 8 (21.62) | 18.2507 |
| 2000's | 9 (24.32) | 29.6817 |
| 2010's | 7 (18.92) | 24.3611 |
| 2020's | 7 (18.92) | 2.80 |
| Authors | Studies |
|---|---|
| Bourgeois, B; Eller, K; Eller, P; Hackl, G; Madl, T; Marsche, G; Posch, F; Reisinger, AC; Sourij, H | 1 |
| Chen, KY; Hou, YC; Lee, PC; Lin, MT; Pai, MH; Wu, JM; Yang, PJ; Yeh, SL | 1 |
| Cai, X; Mao, L; Miao, Y; Wang, M; Zhu, Q | 1 |
| Chen, KY; Chen, PD; Hou, YC; Lee, PC; Lin, MT; Wu, JM; Wu, MH; Yang, PJ; Yeh, SL | 1 |
| Hu, Z; Shi, M; Wang, W; Yan, R; You, Q; Zhang, X; Zhu, Z | 1 |
| Choi, JM; Jeon, SH; Kang, MJ; Kim, SH; Koo, JH | 1 |
| Biasizzo, M; Dolinar, K; Kopitar-Jerala, N; Pirkmajer, S; Trstenjak-Prebanda, M; Turk, B; Završnik, J | 1 |
| Cheng, Y; Li, X; Rong, J; Tse, HF | 1 |
| Bandi, V; Hsu, J; Jahoor, F; Kao, C | 1 |
| Lang, CH; Laufenberg, LJ; Navaratnarajah, M; Pruznak, AM | 1 |
| Bandi, V; Guntupalli, KK; Jahoor, F; Kao, CC | 1 |
| Frost, RA; Kazi, AA; Lang, CH; Pruznak, AM | 1 |
| Holecek, M; Kovarik, M; Muthny, T; Sispera, L | 1 |
| Castillo, L; Coss-Bu, J; Joosten, KF; Schierbeek, H; van Goudoever, JB; Verbruggen, SC | 1 |
| Hasan, Z; Jeppsson, B; Palani, K; Rahman, M; Syk, I; Thorlacius, H | 1 |
| Frost, RA; Lang, CH | 1 |
| Frost, RA; Lang, CH; Pruznak, AM | 1 |
| Holecek, M; Kadlcíková, J; Kessler, BM; Safránek, R; Tilser, I | 1 |
| Chiarla, C; Giovannini, I; Siegel, JH | 1 |
| Cynober, L; De Bandt, JP | 1 |
| Vary, TC | 1 |
| Border, JR; Caruana, J; Cerra, FB; Chenier, R; McMenamy, RH; Moyer, ED | 1 |
| Gray, K; Jurasinski, C; Vary, TC | 1 |
| Ahrendt, GM; Barbul, A; Gardiner, KR; Gardiner, RE | 1 |
| Beaufrère, B; Beylot, M; Bouletreau, P; Chambrier, C; Chassard, D; Guiraud, M; Odeon, M | 1 |
| Abu-Zidan, FM; Walther, S | 1 |
| Angus, B; Chaowagul, W; Curtis, L; Intaranongpai, S; Leelarasamee, A; Permpikul, C; Simpson, JA; Smith, MD; Suputtamongkol, Y; White, NJ | 1 |
| Bakker, J; Curtis, L; Spapen, H; Vincent, JL; Webster, NR | 1 |
| Fischer, JE; Freund, HR; Ryan, JA | 1 |
| Ardawi, MS | 1 |
| Kakegawa, T; Mizote, H; Yoshida, S | 1 |
| Bruzzone, P; Chiarla, C; Goodarzi, S; Placko, R; Siegel, JH; Wiles, CE | 1 |
| Lanza-Jacoby, S; Stein, TP; Yoshida, S | 1 |
| Bieber, LL; Chaudry, IH; Gorman, MW; Harkema, JM | 1 |
| Clarke, IA; Miller, TE; Ormrod, DJ | 1 |
| Bistrian, BR; Blackburn, GL; Hamawy, KJ; Moldawer, LL; Palombo, JD; Pomposelli, JJ | 1 |
| Belzberg, H; Coleman, B; Pittiruti, M; Placko, R; Sganga, G; Siegel, JH; Wedel, S; Wiles, CE | 1 |
1 review(s) available for leucine and Sepsis
| Article | Year |
|---|---|
Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis.
Topics: Amino Acids, Branched-Chain; Animals; Burns; Dietary Supplements; Humans; Intensive Care Units; Leucine; Rats; Sepsis; Wounds and Injuries | 2006 |
5 trial(s) available for leucine and Sepsis
| Article | Year |
|---|---|
Albumin synthesis rates in post-surgical infants and septic adolescents; influence of amino acids, energy, and insulin.
Topics: Adolescent; Albumins; Amino Acids; Blood Glucose; Critical Illness; Cross-Over Studies; Female; Glucose; Homeostasis; Humans; Hyperinsulinism; Infant; Insulin; Insulin Resistance; Intensive Care Units, Pediatric; Leucine; Male; Parenteral Nutrition, Total; Sepsis | 2011 |
Metabolic effects of a D-beta-hydroxybutyrate infusion in septic patients: inhibition of lipolysis and glucose production but not leucine oxidation.
Topics: 3-Hydroxybutyric Acid; Aged; Aged, 80 and over; Analysis of Variance; Carbon Isotopes; Depression, Chemical; Female; Glucose; Humans; Hydroxybutyrates; Infusions, Intravenous; Leucine; Lipolysis; Male; Middle Aged; Oxidation-Reduction; Prospective Studies; Sepsis; Time Factors | 1994 |
A double-blind placebo-controlled study of an infusion of lexipafant (Platelet-activating factor receptor antagonist) in patients with severe sepsis.
Topics: Bacterial Infections; Cytokines; Double-Blind Method; Humans; Imidazoles; Lactates; Leucine; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sepsis | 2000 |
Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis.
Topics: Adult; Aged; Aged, 80 and over; APACHE; Cytokines; Double-Blind Method; Europe; Female; Hemodynamics; Humans; Immunotherapy; Infusions, Intravenous; Lactic Acid; Leucine; Male; Middle Aged; Multiple Organ Failure; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Function Tests; Sepsis; Survival Analysis | 2000 |
Leucine dose response in the reduction of urea production from septic proteolysis and in the stimulation of acute-phase proteins.
Topics: Acute-Phase Proteins; Adult; Amino Acids, Branched-Chain; Energy Intake; Female; Humans; Leucine; Male; Methylhistidines; Multiple Trauma; Nitrogen; Parenteral Nutrition, Total; Proteins; Regression Analysis; Sepsis; Urea | 1991 |
31 other study(ies) available for leucine and Sepsis
| Article | Year |
|---|---|
Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients.
Topics: Aged; Amino Acids, Branched-Chain; Bacteremia; Biomarkers; Case-Control Studies; Female; Humans; Intensive Care Units; Isoleucine; Leucine; Lipoproteins; Magnetic Resonance Spectroscopy; Male; Metabolomics; Middle Aged; Predictive Value of Tests; Prospective Studies; Sepsis; Shock, Septic | 2021 |
Protective Effects of Glutamine and Leucine Supplementation on Sepsis-Induced Skeletal Muscle Injuries.
Topics: Animals; Anti-Inflammatory Agents; Calpain; Cytokines; Glutamine; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Leucine; Macrophages; Male; Mice; Mice, Inbred C57BL; Monocytes; Muscle, Skeletal; Oxidative Stress; Sepsis | 2021 |
Leucine rich alpha-2-glycoprotein 1 (Lrg1) silencing protects against sepsis-mediated brain injury by inhibiting transforming growth factor beta1 (TGFβ1)/SMAD signaling pathway.
Topics: Animals; Apoptosis; Brain Injuries; Glycoproteins; Inflammation; Leucine; Lipopolysaccharides; Mice; Sepsis; Signal Transduction; Transforming Growth Factor beta1 | 2022 |
Glutamine and leucine administration attenuates muscle atrophy in sepsis.
Topics: Amino Acids, Branched-Chain; Animals; Glutamine; Leucine; Mammals; Mice; Muscle, Skeletal; Muscular Atrophy; Sepsis | 2023 |
AMPK activation suppresses mTOR/S6K1 phosphorylation and induces leucine resistance in rats with sepsis.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Drug Resistance; Insulin; Leucine; Male; Phosphorylation; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sepsis; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation.
Topics: Humans; Inflammasomes; Leucine; Lipopolysaccharides; Macrophages; Mitochondrial Proteins; NF-kappa B; Sepsis | 2021 |
Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice.
Topics: Animals; Autophagy; Caspases, Initiator; Cystatin C; Inflammasomes; Interleukin-1beta; Leucine; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Sepsis; Sequestosome-1 Protein; Signal Transduction; Survival Rate; TOR Serine-Threonine Kinases; Up-Regulation | 2021 |
Gallic Acid-L-Leucine Conjugate Protects Mice against LPS-Induced Inflammation and Sepsis via Correcting Proinflammatory Lipid Mediator Profiles and Oxidative Stress.
Topics: Animals; Anti-Inflammatory Agents; Gallic Acid; Inflammation; Leucine; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Sepsis | 2018 |
Alterations in glutamine metabolism and its conversion to citrulline in sepsis.
Topics: Adult; Citrulline; Energy Metabolism; Enterocytes; Female; Glutamine; Humans; Intestinal Mucosa; Leucine; Liver; Male; Middle Aged; Nitrogen Isotopes; Sepsis; Splanchnic Circulation | 2013 |
Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.
Topics: Amino Acid Transport Systems; Animals; Leucine; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Whole-body CO2 production as an index of the metabolic response to sepsis.
Topics: Adult; Carbon Dioxide; Carbon Isotopes; Female; Glucose; Humans; Kinetics; Leucine; Male; Middle Aged; Proteins; Sepsis; Shock, Septic | 2009 |
Sepsis-induced alterations in protein-protein interactions within mTOR complex 1 and the modulating effect of leucine on muscle protein synthesis.
Topics: Animals; Leucine; Male; Multiprotein Complexes; Muscle Proteins; Muscle, Skeletal; Phosphorylation; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Sepsis | 2011 |
Effects of β-hydroxy-β-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats.
Topics: Animals; Cathepsin B; Cathepsin L; Leucine; Lysosomes; Male; Muscle, Skeletal; Oxygen; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Sepsis; Time Factors; Valerates | 2010 |
Geranylgeranyl transferase regulates CXC chemokine formation in alveolar macrophages and neutrophil recruitment in septic lung injury.
Topics: Acute Lung Injury; Alkyl and Aryl Transferases; Animals; CD40 Ligand; Chemokines, CXC; Imidazoles; Leucine; Ligation; Macrophage-1 Antigen; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Naphthalenes; Neutrophil Infiltration; Neutrophils; Receptors, Interleukin-8B; Sepsis; Tumor Necrosis Factor-alpha | 2013 |
Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation.
Topics: Animals; Blotting, Western; Carrier Proteins; Insulin; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Peptide Chain Initiation, Translational; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Biosynthesis; Protein Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Sepsis; Signal Transduction; Stimulation, Chemical; TOR Serine-Threonine Kinases | 2004 |
TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle.
Topics: Animals; Cecum; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Heart; Insulin; Leucine; Male; Myocardium; Phosphorylation; Protein Biosynthesis; Protein Kinases; Punctures; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Sepsis; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2005 |
Effects of proteasome inhibitors MG132, ZL3VS and AdaAhx3L3VS on protein metabolism in septic rats.
Topics: Animals; Cysteine Proteinase Inhibitors; Kidney; Leucine; Leupeptins; Liver; Male; Muscle, Skeletal; Oligopeptides; Oxidation-Reduction; Proteasome Inhibitors; Proteins; Rats; Rats, Wistar; Sepsis; Spleen | 2004 |
Plasma arginine correlations in trauma and sepsis.
Topics: Adolescent; Adult; Amino Acids; Arginine; Female; Humans; Isoleucine; Leucine; Lysine; Male; Ornithine; Parenteral Nutrition, Total; Prospective Studies; Sepsis; Wounds and Injuries | 2006 |
Acute oral leucine administration stimulates protein synthesis during chronic sepsis through enhanced association of eukaryotic initiation factor 4G with eukaryotic initiation factor 4E in rats.
Topics: Adaptor Proteins, Signal Transducing; Administration, Oral; Animals; Chronic Disease; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Leucine; Male; Phosphorylation; Protein Binding; Protein Biosynthesis; Protein Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sepsis; Time Factors; TOR Serine-Threonine Kinases | 2007 |
Multiple systems organ failure: IV. Imbalances in plasma amino acids associated with exogenous albumin in the trauma-septic patient.
Topics: Accidents, Traffic; Albumins; Amino Acids; Humans; Injections, Intravenous; Isoleucine; Leucine; Retrospective Studies; Sepsis; Venous Pressure; Wounds and Injuries; Wounds, Gunshot; Wounds, Stab | 1981 |
Modulation of skeletal muscle protein synthesis by amino acids and insulin during sepsis.
Topics: Amino Acids; Amino Acids, Branched-Chain; Animals; Bacteremia; Insulin; Isoleucine; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; RNA; Sepsis; Valine | 1995 |
Failure of intestinal amino acid absorptive mechanisms in sepsis.
Topics: Amino Acids; Aminobutyrates; Animals; Glutamic Acid; Intestinal Absorption; Leucine; Male; Proline; Rats; Rats, Sprague-Dawley; Sepsis | 1995 |
Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs.
Topics: Animals; Blood Pressure; Cardiac Output; Endotoxemia; Escherichia coli Infections; Heart Rate; Hemodynamics; Leucine; Platelet Activating Factor; Sepsis; Stroke Volume; Swine | 1996 |
Amino acid derangements in patients with sepsis: treatment with branched chain amino acid rich infusions.
Topics: Amino Acids; Blood Glucose; Glucagon; Humans; Insulin; Isoleucine; Leucine; Metabolic Diseases; Parenteral Nutrition; Regression Analysis; Sepsis; Valine | 1978 |
Effects of xylitol- and/or glutamine-supplemented parenteral nutrition on septic rats.
Topics: Amino Acids; Animals; Glutamine; Leucine; Liver; Male; Muscle Proteins; Nitrogen; Parenteral Nutrition; Rats; Rats, Inbred Strains; RNA; Sepsis; Survival Rate; Tyrosine; Xylitol | 1992 |
[Protein turnover and amino acids metabolism in septic rats].
Topics: Amino Acids; Animals; Female; Glutamine; Leucine; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Sepsis | 1992 |
Leucine and glutamine metabolism in septic rats.
Topics: Animals; Carbon Isotopes; Escherichia coli Infections; Female; Glutamine; Kinetics; Leucine; Mathematics; Models, Biological; Parenteral Nutrition, Total; Rats; Rats, Inbred Strains; Reference Values; Sepsis | 1991 |
Metabolic interaction between skeletal muscle and liver during bacteremia.
Topics: Amino Acids, Branched-Chain; Animals; Dogs; Escherichia coli Infections; Keto Acids; Leucine; Liver; Male; Muscles; Sepsis | 1988 |
Immunopotentiation in infectious disease, II. Effect of bestatin on experimental infection.
Topics: Adjuvants, Immunologic; Animals; Anti-Bacterial Agents; Drug Therapy, Combination; Escherichia coli Infections; Female; Klebsiella Infections; Klebsiella pneumoniae; Leucine; Male; Peritonitis; Pneumonia; Pyelonephritis; Rats; Sepsis | 1985 |
Comparison of different techniques for estimating rates of protein synthesis in vivo in healthy and bacteraemic rats.
Topics: Animals; Carbon Radioisotopes; Kinetics; Leucine; Male; Methods; Protein Biosynthesis; Rats; Rats, Inbred Strains; Sepsis; Tissue Distribution | 1985 |
Increased dependence of leucine in posttraumatic sepsis: leucine/tyrosine clearance ratio as an indicator of hepatic impairment in septic multiple organ failure syndrome.
Topics: Adolescent; Adult; Alanine; Amino Acids; Amino Acids, Essential; Aspartic Acid; Glutamates; Humans; Leucine; Liver; Metabolic Clearance Rate; Multiple Organ Failure; Muscles; Proline; Sepsis; Tyrosine; Wounds and Injuries | 1985 |