leucine and Sepsis

leucine has been researched along with Sepsis in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19906 (16.22)18.7374
1990's8 (21.62)18.2507
2000's9 (24.32)29.6817
2010's7 (18.92)24.3611
2020's7 (18.92)2.80

Authors

AuthorsStudies
Bourgeois, B; Eller, K; Eller, P; Hackl, G; Madl, T; Marsche, G; Posch, F; Reisinger, AC; Sourij, H1
Chen, KY; Hou, YC; Lee, PC; Lin, MT; Pai, MH; Wu, JM; Yang, PJ; Yeh, SL1
Cai, X; Mao, L; Miao, Y; Wang, M; Zhu, Q1
Chen, KY; Chen, PD; Hou, YC; Lee, PC; Lin, MT; Wu, JM; Wu, MH; Yang, PJ; Yeh, SL1
Hu, Z; Shi, M; Wang, W; Yan, R; You, Q; Zhang, X; Zhu, Z1
Choi, JM; Jeon, SH; Kang, MJ; Kim, SH; Koo, JH1
Biasizzo, M; Dolinar, K; Kopitar-Jerala, N; Pirkmajer, S; Trstenjak-Prebanda, M; Turk, B; Završnik, J1
Cheng, Y; Li, X; Rong, J; Tse, HF1
Bandi, V; Hsu, J; Jahoor, F; Kao, C1
Lang, CH; Laufenberg, LJ; Navaratnarajah, M; Pruznak, AM1
Bandi, V; Guntupalli, KK; Jahoor, F; Kao, CC1
Frost, RA; Kazi, AA; Lang, CH; Pruznak, AM1
Holecek, M; Kovarik, M; Muthny, T; Sispera, L1
Castillo, L; Coss-Bu, J; Joosten, KF; Schierbeek, H; van Goudoever, JB; Verbruggen, SC1
Hasan, Z; Jeppsson, B; Palani, K; Rahman, M; Syk, I; Thorlacius, H1
Frost, RA; Lang, CH1
Frost, RA; Lang, CH; Pruznak, AM1
Holecek, M; Kadlcíková, J; Kessler, BM; Safránek, R; Tilser, I1
Chiarla, C; Giovannini, I; Siegel, JH1
Cynober, L; De Bandt, JP1
Vary, TC1
Border, JR; Caruana, J; Cerra, FB; Chenier, R; McMenamy, RH; Moyer, ED1
Gray, K; Jurasinski, C; Vary, TC1
Ahrendt, GM; Barbul, A; Gardiner, KR; Gardiner, RE1
Beaufrère, B; Beylot, M; Bouletreau, P; Chambrier, C; Chassard, D; Guiraud, M; Odeon, M1
Abu-Zidan, FM; Walther, S1
Angus, B; Chaowagul, W; Curtis, L; Intaranongpai, S; Leelarasamee, A; Permpikul, C; Simpson, JA; Smith, MD; Suputtamongkol, Y; White, NJ1
Bakker, J; Curtis, L; Spapen, H; Vincent, JL; Webster, NR1
Fischer, JE; Freund, HR; Ryan, JA1
Ardawi, MS1
Kakegawa, T; Mizote, H; Yoshida, S1
Bruzzone, P; Chiarla, C; Goodarzi, S; Placko, R; Siegel, JH; Wiles, CE1
Lanza-Jacoby, S; Stein, TP; Yoshida, S1
Bieber, LL; Chaudry, IH; Gorman, MW; Harkema, JM1
Clarke, IA; Miller, TE; Ormrod, DJ1
Bistrian, BR; Blackburn, GL; Hamawy, KJ; Moldawer, LL; Palombo, JD; Pomposelli, JJ1
Belzberg, H; Coleman, B; Pittiruti, M; Placko, R; Sganga, G; Siegel, JH; Wedel, S; Wiles, CE1

Reviews

1 review(s) available for leucine and Sepsis

ArticleYear
Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis.
    The Journal of nutrition, 2006, Volume: 136, Issue:1 Suppl

    Topics: Amino Acids, Branched-Chain; Animals; Burns; Dietary Supplements; Humans; Intensive Care Units; Leucine; Rats; Sepsis; Wounds and Injuries

2006

Trials

5 trial(s) available for leucine and Sepsis

ArticleYear
Albumin synthesis rates in post-surgical infants and septic adolescents; influence of amino acids, energy, and insulin.
    Clinical nutrition (Edinburgh, Scotland), 2011, Volume: 30, Issue:4

    Topics: Adolescent; Albumins; Amino Acids; Blood Glucose; Critical Illness; Cross-Over Studies; Female; Glucose; Homeostasis; Humans; Hyperinsulinism; Infant; Insulin; Insulin Resistance; Intensive Care Units, Pediatric; Leucine; Male; Parenteral Nutrition, Total; Sepsis

2011
Metabolic effects of a D-beta-hydroxybutyrate infusion in septic patients: inhibition of lipolysis and glucose production but not leucine oxidation.
    Critical care medicine, 1994, Volume: 22, Issue:7

    Topics: 3-Hydroxybutyric Acid; Aged; Aged, 80 and over; Analysis of Variance; Carbon Isotopes; Depression, Chemical; Female; Glucose; Humans; Hydroxybutyrates; Infusions, Intravenous; Leucine; Lipolysis; Male; Middle Aged; Oxidation-Reduction; Prospective Studies; Sepsis; Time Factors

1994
A double-blind placebo-controlled study of an infusion of lexipafant (Platelet-activating factor receptor antagonist) in patients with severe sepsis.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:3

    Topics: Bacterial Infections; Cytokines; Double-Blind Method; Humans; Imidazoles; Lactates; Leucine; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sepsis

2000
Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis.
    Critical care medicine, 2000, Volume: 28, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; APACHE; Cytokines; Double-Blind Method; Europe; Female; Hemodynamics; Humans; Immunotherapy; Infusions, Intravenous; Lactic Acid; Leucine; Male; Middle Aged; Multiple Organ Failure; Platelet Activating Factor; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory Function Tests; Sepsis; Survival Analysis

2000
Leucine dose response in the reduction of urea production from septic proteolysis and in the stimulation of acute-phase proteins.
    Surgery, 1991, Volume: 109, Issue:6

    Topics: Acute-Phase Proteins; Adult; Amino Acids, Branched-Chain; Energy Intake; Female; Humans; Leucine; Male; Methylhistidines; Multiple Trauma; Nitrogen; Parenteral Nutrition, Total; Proteins; Regression Analysis; Sepsis; Urea

1991

Other Studies

31 other study(ies) available for leucine and Sepsis

ArticleYear
Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients.
    Nutrients, 2021, Sep-03, Volume: 13, Issue:9

    Topics: Aged; Amino Acids, Branched-Chain; Bacteremia; Biomarkers; Case-Control Studies; Female; Humans; Intensive Care Units; Isoleucine; Leucine; Lipoproteins; Magnetic Resonance Spectroscopy; Male; Metabolomics; Middle Aged; Predictive Value of Tests; Prospective Studies; Sepsis; Shock, Septic

2021
Protective Effects of Glutamine and Leucine Supplementation on Sepsis-Induced Skeletal Muscle Injuries.
    International journal of molecular sciences, 2021, Nov-30, Volume: 22, Issue:23

    Topics: Animals; Anti-Inflammatory Agents; Calpain; Cytokines; Glutamine; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Leucine; Macrophages; Male; Mice; Mice, Inbred C57BL; Monocytes; Muscle, Skeletal; Oxidative Stress; Sepsis

2021
Leucine rich alpha-2-glycoprotein 1 (Lrg1) silencing protects against sepsis-mediated brain injury by inhibiting transforming growth factor beta1 (TGFβ1)/SMAD signaling pathway.
    Bioengineered, 2022, Volume: 13, Issue:3

    Topics: Animals; Apoptosis; Brain Injuries; Glycoproteins; Inflammation; Leucine; Lipopolysaccharides; Mice; Sepsis; Signal Transduction; Transforming Growth Factor beta1

2022
Glutamine and leucine administration attenuates muscle atrophy in sepsis.
    Life sciences, 2023, Feb-01, Volume: 314

    Topics: Amino Acids, Branched-Chain; Animals; Glutamine; Leucine; Mammals; Mice; Muscle, Skeletal; Muscular Atrophy; Sepsis

2023
AMPK activation suppresses mTOR/S6K1 phosphorylation and induces leucine resistance in rats with sepsis.
    Cell biology international, 2020, Volume: 44, Issue:5

    Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Drug Resistance; Insulin; Leucine; Male; Phosphorylation; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sepsis; Signal Transduction; TOR Serine-Threonine Kinases

2020
Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation.
    Biomaterials, 2021, Volume: 274

    Topics: Humans; Inflammasomes; Leucine; Lipopolysaccharides; Macrophages; Mitochondrial Proteins; NF-kappa B; Sepsis

2021
Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice.
    Cells, 2021, 08-12, Volume: 10, Issue:8

    Topics: Animals; Autophagy; Caspases, Initiator; Cystatin C; Inflammasomes; Interleukin-1beta; Leucine; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Reactive Oxygen Species; Sepsis; Sequestosome-1 Protein; Signal Transduction; Survival Rate; TOR Serine-Threonine Kinases; Up-Regulation

2021
Gallic Acid-L-Leucine Conjugate Protects Mice against LPS-Induced Inflammation and Sepsis via Correcting Proinflammatory Lipid Mediator Profiles and Oxidative Stress.
    Oxidative medicine and cellular longevity, 2018, Volume: 2018

    Topics: Animals; Anti-Inflammatory Agents; Gallic Acid; Inflammation; Leucine; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Sepsis

2018
Alterations in glutamine metabolism and its conversion to citrulline in sepsis.
    American journal of physiology. Endocrinology and metabolism, 2013, Jun-15, Volume: 304, Issue:12

    Topics: Adult; Citrulline; Energy Metabolism; Enterocytes; Female; Glutamine; Humans; Intestinal Mucosa; Leucine; Liver; Male; Middle Aged; Nitrogen Isotopes; Sepsis; Splanchnic Circulation

2013
Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle.
    Amino acids, 2014, Volume: 46, Issue:12

    Topics: Amino Acid Transport Systems; Animals; Leucine; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction; TOR Serine-Threonine Kinases

2014
Whole-body CO2 production as an index of the metabolic response to sepsis.
    Shock (Augusta, Ga.), 2009, Volume: 32, Issue:1

    Topics: Adult; Carbon Dioxide; Carbon Isotopes; Female; Glucose; Humans; Kinetics; Leucine; Male; Middle Aged; Proteins; Sepsis; Shock, Septic

2009
Sepsis-induced alterations in protein-protein interactions within mTOR complex 1 and the modulating effect of leucine on muscle protein synthesis.
    Shock (Augusta, Ga.), 2011, Volume: 35, Issue:2

    Topics: Animals; Leucine; Male; Multiprotein Complexes; Muscle Proteins; Muscle, Skeletal; Phosphorylation; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Sepsis

2011
Effects of β-hydroxy-β-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats.
    Journal of physiology and biochemistry, 2010, Volume: 66, Issue:4

    Topics: Animals; Cathepsin B; Cathepsin L; Leucine; Lysosomes; Male; Muscle, Skeletal; Oxygen; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Sepsis; Time Factors; Valerates

2010
Geranylgeranyl transferase regulates CXC chemokine formation in alveolar macrophages and neutrophil recruitment in septic lung injury.
    American journal of physiology. Lung cellular and molecular physiology, 2013, Feb-15, Volume: 304, Issue:4

    Topics: Acute Lung Injury; Alkyl and Aryl Transferases; Animals; CD40 Ligand; Chemokines, CXC; Imidazoles; Leucine; Ligation; Macrophage-1 Antigen; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Naphthalenes; Neutrophil Infiltration; Neutrophils; Receptors, Interleukin-8B; Sepsis; Tumor Necrosis Factor-alpha

2013
Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation.
    American journal of physiology. Endocrinology and metabolism, 2004, Volume: 287, Issue:4

    Topics: Animals; Blotting, Western; Carrier Proteins; Insulin; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Peptide Chain Initiation, Translational; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Biosynthesis; Protein Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Sepsis; Signal Transduction; Stimulation, Chemical; TOR Serine-Threonine Kinases

2004
TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle.
    Journal of cellular biochemistry, 2005, Feb-01, Volume: 94, Issue:2

    Topics: Animals; Cecum; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Heart; Insulin; Leucine; Male; Myocardium; Phosphorylation; Protein Biosynthesis; Protein Kinases; Punctures; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Sepsis; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha

2005
Effects of proteasome inhibitors MG132, ZL3VS and AdaAhx3L3VS on protein metabolism in septic rats.
    International journal of experimental pathology, 2004, Volume: 85, Issue:6

    Topics: Animals; Cysteine Proteinase Inhibitors; Kidney; Leucine; Leupeptins; Liver; Male; Muscle, Skeletal; Oligopeptides; Oxidation-Reduction; Proteasome Inhibitors; Proteins; Rats; Rats, Wistar; Sepsis; Spleen

2004
Plasma arginine correlations in trauma and sepsis.
    Amino acids, 2006, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Amino Acids; Arginine; Female; Humans; Isoleucine; Leucine; Lysine; Male; Ornithine; Parenteral Nutrition, Total; Prospective Studies; Sepsis; Wounds and Injuries

2006
Acute oral leucine administration stimulates protein synthesis during chronic sepsis through enhanced association of eukaryotic initiation factor 4G with eukaryotic initiation factor 4E in rats.
    The Journal of nutrition, 2007, Volume: 137, Issue:9

    Topics: Adaptor Proteins, Signal Transducing; Administration, Oral; Animals; Chronic Disease; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Leucine; Male; Phosphorylation; Protein Binding; Protein Biosynthesis; Protein Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Sepsis; Time Factors; TOR Serine-Threonine Kinases

2007
Multiple systems organ failure: IV. Imbalances in plasma amino acids associated with exogenous albumin in the trauma-septic patient.
    The Journal of trauma, 1981, Volume: 21, Issue:7

    Topics: Accidents, Traffic; Albumins; Amino Acids; Humans; Injections, Intravenous; Isoleucine; Leucine; Retrospective Studies; Sepsis; Venous Pressure; Wounds and Injuries; Wounds, Gunshot; Wounds, Stab

1981
Modulation of skeletal muscle protein synthesis by amino acids and insulin during sepsis.
    Metabolism: clinical and experimental, 1995, Volume: 44, Issue:9

    Topics: Amino Acids; Amino Acids, Branched-Chain; Animals; Bacteremia; Insulin; Isoleucine; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; RNA; Sepsis; Valine

1995
Failure of intestinal amino acid absorptive mechanisms in sepsis.
    Journal of the American College of Surgeons, 1995, Volume: 181, Issue:5

    Topics: Amino Acids; Aminobutyrates; Animals; Glutamic Acid; Intestinal Absorption; Leucine; Male; Proline; Rats; Rats, Sprague-Dawley; Sepsis

1995
Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs.
    The European journal of surgery = Acta chirurgica, 1996, Volume: 162, Issue:6

    Topics: Animals; Blood Pressure; Cardiac Output; Endotoxemia; Escherichia coli Infections; Heart Rate; Hemodynamics; Leucine; Platelet Activating Factor; Sepsis; Stroke Volume; Swine

1996
Amino acid derangements in patients with sepsis: treatment with branched chain amino acid rich infusions.
    Annals of surgery, 1978, Volume: 188, Issue:3

    Topics: Amino Acids; Blood Glucose; Glucagon; Humans; Insulin; Isoleucine; Leucine; Metabolic Diseases; Parenteral Nutrition; Regression Analysis; Sepsis; Valine

1978
Effects of xylitol- and/or glutamine-supplemented parenteral nutrition on septic rats.
    Clinical science (London, England : 1979), 1992, Volume: 82, Issue:4

    Topics: Amino Acids; Animals; Glutamine; Leucine; Liver; Male; Muscle Proteins; Nitrogen; Parenteral Nutrition; Rats; Rats, Inbred Strains; RNA; Sepsis; Survival Rate; Tyrosine; Xylitol

1992
[Protein turnover and amino acids metabolism in septic rats].
    Nihon Geka Gakkai zasshi, 1992, Volume: 93, Issue:11

    Topics: Amino Acids; Animals; Female; Glutamine; Leucine; Protein Biosynthesis; Proteins; Rats; Rats, Sprague-Dawley; Sepsis

1992
Leucine and glutamine metabolism in septic rats.
    The Biochemical journal, 1991, Jun-01, Volume: 276 ( Pt 2)

    Topics: Animals; Carbon Isotopes; Escherichia coli Infections; Female; Glutamine; Kinetics; Leucine; Mathematics; Models, Biological; Parenteral Nutrition, Total; Rats; Rats, Inbred Strains; Reference Values; Sepsis

1991
Metabolic interaction between skeletal muscle and liver during bacteremia.
    Archives of surgery (Chicago, Ill. : 1960), 1988, Volume: 123, Issue:11

    Topics: Amino Acids, Branched-Chain; Animals; Dogs; Escherichia coli Infections; Keto Acids; Leucine; Liver; Male; Muscles; Sepsis

1988
Immunopotentiation in infectious disease, II. Effect of bestatin on experimental infection.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1985, Volume: 4, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Anti-Bacterial Agents; Drug Therapy, Combination; Escherichia coli Infections; Female; Klebsiella Infections; Klebsiella pneumoniae; Leucine; Male; Peritonitis; Pneumonia; Pyelonephritis; Rats; Sepsis

1985
Comparison of different techniques for estimating rates of protein synthesis in vivo in healthy and bacteraemic rats.
    The Biochemical journal, 1985, Feb-15, Volume: 226, Issue:1

    Topics: Animals; Carbon Radioisotopes; Kinetics; Leucine; Male; Methods; Protein Biosynthesis; Rats; Rats, Inbred Strains; Sepsis; Tissue Distribution

1985
Increased dependence of leucine in posttraumatic sepsis: leucine/tyrosine clearance ratio as an indicator of hepatic impairment in septic multiple organ failure syndrome.
    Surgery, 1985, Volume: 98, Issue:3

    Topics: Adolescent; Adult; Alanine; Amino Acids; Amino Acids, Essential; Aspartic Acid; Glutamates; Humans; Leucine; Liver; Metabolic Clearance Rate; Multiple Organ Failure; Muscles; Proline; Sepsis; Tyrosine; Wounds and Injuries

1985