lapachol and Malaria
lapachol has been researched along with Malaria in 1 studies
lapachol : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone substituted by hydroxy and 3-methylbut-2-en-1-yl groups at positions 2 and 3, respectively. It is a natural compound that exhibits antibacterial and anticancer properties, first isolated in 1882 from the bark of Tabebuia avellanedae.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"The antimalarial activity of benzo[a]phenazines synthesized from 1,2-naphthoquinone, lapachol, beta-lapachone and several derivatives have been tested against Plasmodium falciparum in vitro using isolates of parasites with various susceptibilities to chloroquine and/or mefloquine." | 7.72 | Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. ( Carvalho, LH; da Silva Filho, JF; da Silva, MJ; de Andrade-Neto, VF; Goulart, MO; Krettli, AU; Pinto, AV; Pinto, Mdo C; Zalis, MG, 2004) |
"The antimalarial activity of benzo[a]phenazines synthesized from 1,2-naphthoquinone, lapachol, beta-lapachone and several derivatives have been tested against Plasmodium falciparum in vitro using isolates of parasites with various susceptibilities to chloroquine and/or mefloquine." | 3.72 | Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. ( Carvalho, LH; da Silva Filho, JF; da Silva, MJ; de Andrade-Neto, VF; Goulart, MO; Krettli, AU; Pinto, AV; Pinto, Mdo C; Zalis, MG, 2004) |
Research
Studies (1)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
de Andrade-Neto, VF | 1 |
Goulart, MO | 1 |
da Silva Filho, JF | 1 |
da Silva, MJ | 1 |
Pinto, Mdo C | 1 |
Pinto, AV | 1 |
Zalis, MG | 1 |
Carvalho, LH | 1 |
Krettli, AU | 1 |
Other Studies
1 other study available for lapachol and Malaria
Article | Year |
---|---|
Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Malaria; Mice; Naphthoquinones; Phenazines | 2004 |