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lapachol and Malaria

lapachol has been researched along with Malaria in 1 studies

lapachol : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone substituted by hydroxy and 3-methylbut-2-en-1-yl groups at positions 2 and 3, respectively. It is a natural compound that exhibits antibacterial and anticancer properties, first isolated in 1882 from the bark of Tabebuia avellanedae.

Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

Research Excerpts

ExcerptRelevanceReference
"The antimalarial activity of benzo[a]phenazines synthesized from 1,2-naphthoquinone, lapachol, beta-lapachone and several derivatives have been tested against Plasmodium falciparum in vitro using isolates of parasites with various susceptibilities to chloroquine and/or mefloquine."7.72Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. ( Carvalho, LH; da Silva Filho, JF; da Silva, MJ; de Andrade-Neto, VF; Goulart, MO; Krettli, AU; Pinto, AV; Pinto, Mdo C; Zalis, MG, 2004)
"The antimalarial activity of benzo[a]phenazines synthesized from 1,2-naphthoquinone, lapachol, beta-lapachone and several derivatives have been tested against Plasmodium falciparum in vitro using isolates of parasites with various susceptibilities to chloroquine and/or mefloquine."3.72Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. ( Carvalho, LH; da Silva Filho, JF; da Silva, MJ; de Andrade-Neto, VF; Goulart, MO; Krettli, AU; Pinto, AV; Pinto, Mdo C; Zalis, MG, 2004)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Andrade-Neto, VF1
Goulart, MO1
da Silva Filho, JF1
da Silva, MJ1
Pinto, Mdo C1
Pinto, AV1
Zalis, MG1
Carvalho, LH1
Krettli, AU1

Other Studies

1 other study available for lapachol and Malaria

ArticleYear
Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
    Bioorganic & medicinal chemistry letters, 2004, Mar-08, Volume: 14, Issue:5

    Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Malaria; Mice; Naphthoquinones; Phenazines

2004
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