kynurenine has been researched along with Sepsis in 15 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study provided novel insights into the tryptophan-IDO-1-kynurenine-dependent mechanisms that underlie inflammatory cytokine-induced skeletal muscle catabolism during intra-abdominal sepsis." | 8.31 | Interleukin-6 promotes skeletal muscle catabolism by activating tryptophan-indoleamine 2,3-dioxygenase 1-kynurenine pathway during intra-abdominal sepsis. ( Ding, C; Feng, D; Gong, J; Gu, L; Guo, Z; Lv, T; Xie, T; Xu, Y; Zhang, L; Zhang, T; Zhu, F, 2023) |
| "It has recently been shown that an increased plasma level of the tryptophan catabolite kynurenine is an early indicator for the development of sepsis in major trauma patients." | 7.76 | Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients. ( Domanska, G; Fusch, G; Gruendling, M; Haas, JP; Holtfreter, B; Reinke, P; Schefold, JC; Schuett, C; Westerholt, A; Zeden, JP, 2010) |
| "Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and it accounts for about half of the cases of acute kidney injury (AKI)." | 6.82 | Kynurenine Pathway-An Underestimated Factor Modulating Innate Immunity in Sepsis-Induced Acute Kidney Injury? ( Krupa, A; Krupa, MM; Pawlak, K, 2022) |
| "Thirty-six patients with severe sepsis/septic shock and sepsis-associated immunosuppression (assessed using monocytic human leukocyte antigen-DR (mHLA-DR) expression) were assessed in a controlled trial of GM-CSF or placebo treatment for 8 days." | 6.75 | Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock. ( Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP, 2010) |
| "Sepsis was induced by cecal ligation/perforation (CLP)." | 5.43 | Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy. ( Gao, R; Kan, MQ; Wang, SG; Yang, RH; Zhang, SG, 2016) |
| "In response to treatment of severe sepsis, the median KT ratio decreased from 162 [IQR 100-286] on day 0 to 89 [65-139] by day 7; p = 0." | 5.37 | An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function. ( Anstey, NM; Darcy, CJ; Davis, JS; McNeil, YR; Stephens, DP; Woodberry, T; Yeo, TW, 2011) |
| " In this review, we highlight these pathways as sources of serotonin and melatonin, which then regulate neurotransmission, influence circadian rhythm, cognitive functions, and the development of delirium." | 5.12 | Tryptophan: A Unique Role in the Critically Ill. ( Kanova, M; Kohout, P, 2021) |
| " Lactate and kynurenine could be useful biomarkers for the diagnosis and recovery of AKI following sepsis." | 4.31 | Identification of Biomarkers for the Diagnosis of Sepsis-Associated Acute Kidney Injury and Prediction of Renal Recovery in the Intensive Care Unit. ( Ahn, S; Chung, K; Kim, YS; Kwak, SH; Lee, SG; Lee, SH; Leem, AY; Park, MS; Shin, MH, 2023) |
| "This study provided novel insights into the tryptophan-IDO-1-kynurenine-dependent mechanisms that underlie inflammatory cytokine-induced skeletal muscle catabolism during intra-abdominal sepsis." | 4.31 | Interleukin-6 promotes skeletal muscle catabolism by activating tryptophan-indoleamine 2,3-dioxygenase 1-kynurenine pathway during intra-abdominal sepsis. ( Ding, C; Feng, D; Gong, J; Gu, L; Guo, Z; Lv, T; Xie, T; Xu, Y; Zhang, L; Zhang, T; Zhu, F, 2023) |
| "It has recently been shown that an increased plasma level of the tryptophan catabolite kynurenine is an early indicator for the development of sepsis in major trauma patients." | 3.76 | Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients. ( Domanska, G; Fusch, G; Gruendling, M; Haas, JP; Holtfreter, B; Reinke, P; Schefold, JC; Schuett, C; Westerholt, A; Zeden, JP, 2010) |
| "Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, and it accounts for about half of the cases of acute kidney injury (AKI)." | 2.82 | Kynurenine Pathway-An Underestimated Factor Modulating Innate Immunity in Sepsis-Induced Acute Kidney Injury? ( Krupa, A; Krupa, MM; Pawlak, K, 2022) |
| "Thirty-six patients with severe sepsis/septic shock and sepsis-associated immunosuppression (assessed using monocytic human leukocyte antigen-DR (mHLA-DR) expression) were assessed in a controlled trial of GM-CSF or placebo treatment for 8 days." | 2.75 | Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock. ( Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP, 2010) |
| "Viral sepsis has been proposed as an accurate term to describe all multisystemic dysregulations and clinical findings in severe and critically ill COVID-19 patients." | 1.62 | Immunometabolic signatures predict risk of progression to sepsis in COVID-19. ( Borrego, JC; Castañeda-Delgado, JE; Enciso-Moreno, JA; Fernández-Ruiz, JC; Herrera-Van Oostdam, AS; López, JA; López-Hernández, Y; Mandal, R; Monárrez-Espino, J; Ochoa-González, F; Oropeza-Valdez, JJ; Soto-Guzmán, E; Trejo Medinilla, FM; Wishart, DS; Zhang, L; Zheng, J, 2021) |
| "Sepsis was induced by cecal ligation/perforation (CLP)." | 1.43 | Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy. ( Gao, R; Kan, MQ; Wang, SG; Yang, RH; Zhang, SG, 2016) |
| "In response to treatment of severe sepsis, the median KT ratio decreased from 162 [IQR 100-286] on day 0 to 89 [65-139] by day 7; p = 0." | 1.37 | An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function. ( Anstey, NM; Darcy, CJ; Davis, JS; McNeil, YR; Stephens, DP; Woodberry, T; Yeo, TW, 2011) |
| "The incidence of bacteremic sepsis (BS), adult respiratory distress syndrome (ARDS), multiple organ dysfunction/failure syndromes (MODS/MOF), and death was prospectively documented in 22 trauma patients with a mean ISS of 24." | 1.33 | Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma. ( Fleming, AW; Fuchs, D; Neurauter, G; Pellegrin, K; Peterson, VM; Wirleitner, B, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 6 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herrera-Van Oostdam, AS | 1 |
| Castañeda-Delgado, JE | 1 |
| Oropeza-Valdez, JJ | 1 |
| Borrego, JC | 1 |
| Monárrez-Espino, J | 1 |
| Zheng, J | 1 |
| Mandal, R | 1 |
| Zhang, L | 2 |
| Soto-Guzmán, E | 1 |
| Fernández-Ruiz, JC | 1 |
| Ochoa-González, F | 1 |
| Trejo Medinilla, FM | 1 |
| López, JA | 1 |
| Wishart, DS | 1 |
| Enciso-Moreno, JA | 1 |
| López-Hernández, Y | 1 |
| Kanova, M | 1 |
| Kohout, P | 1 |
| Lerch, S | 1 |
| Schefold, JC | 3 |
| Spinetti, T | 1 |
| Krupa, A | 1 |
| Krupa, MM | 1 |
| Pawlak, K | 1 |
| Kwak, SH | 1 |
| Ahn, S | 1 |
| Shin, MH | 1 |
| Leem, AY | 1 |
| Lee, SH | 1 |
| Chung, K | 1 |
| Kim, YS | 1 |
| Lee, SG | 1 |
| Park, MS | 1 |
| Xie, T | 1 |
| Lv, T | 1 |
| Zhang, T | 1 |
| Feng, D | 1 |
| Zhu, F | 1 |
| Xu, Y | 1 |
| Gu, L | 1 |
| Guo, Z | 1 |
| Ding, C | 1 |
| Gong, J | 1 |
| McGarrity, S | 1 |
| Anuforo, Ó | 1 |
| Halldórsson, H | 1 |
| Bergmann, A | 1 |
| Halldórsson, S | 1 |
| Palsson, S | 1 |
| Henriksen, HH | 1 |
| Johansson, PI | 1 |
| Rolfsson, Ó | 1 |
| Ishida, Y | 1 |
| Fujita, H | 1 |
| Aratani, S | 1 |
| Chijiiwa, M | 1 |
| Taniguchi, N | 1 |
| Yokota, M | 1 |
| Ogihara, Y | 1 |
| Uoshima, N | 1 |
| Nagashima, F | 1 |
| Uchino, H | 1 |
| Nakajima, T | 1 |
| Gao, R | 1 |
| Kan, MQ | 1 |
| Wang, SG | 1 |
| Yang, RH | 1 |
| Zhang, SG | 1 |
| Lögters, TT | 1 |
| Laryea, MD | 1 |
| Altrichter, J | 1 |
| Sokolowski, J | 1 |
| Cinatl, J | 1 |
| Reipen, J | 1 |
| Linhart, W | 1 |
| Windolf, J | 1 |
| Scholz, M | 1 |
| Wild, M | 1 |
| Zeden, JP | 2 |
| Pschowski, R | 1 |
| Hammoud, B | 1 |
| Fotopoulou, C | 1 |
| Hasper, D | 1 |
| Fusch, G | 2 |
| Von Haehling, S | 1 |
| Volk, HD | 1 |
| Meisel, C | 1 |
| Schütt, C | 1 |
| Reinke, P | 2 |
| Holtfreter, B | 1 |
| Domanska, G | 1 |
| Haas, JP | 1 |
| Gruendling, M | 1 |
| Westerholt, A | 1 |
| Schuett, C | 1 |
| Darcy, CJ | 1 |
| Davis, JS | 1 |
| Woodberry, T | 1 |
| McNeil, YR | 1 |
| Stephens, DP | 1 |
| Yeo, TW | 1 |
| Anstey, NM | 1 |
| Pellegrin, K | 1 |
| Neurauter, G | 1 |
| Wirleitner, B | 1 |
| Fleming, AW | 1 |
| Peterson, VM | 1 |
| Fuchs, D | 1 |
| Heyes, MP | 1 |
| Lackner, A | 1 |
3 reviews available for kynurenine and Sepsis
| Article | Year |
|---|---|
Tryptophan: A Unique Role in the Critically Ill.
Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; | 2021 |
The Role of Kynurenines Produced by Indolamine-2,3-Dioxygenase 1 in Sepsis.
Topics: Animals; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Sepsis; T-Lymphocytes, Regu | 2022 |
Kynurenine Pathway-An Underestimated Factor Modulating Innate Immunity in Sepsis-Induced Acute Kidney Injury?
Topics: Acute Kidney Injury; Humans; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Sep | 2022 |
1 trial available for kynurenine and Sepsis
| Article | Year |
|---|---|
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.
Topics: Aged; Calcitonin; Calcitonin Gene-Related Peptide; Granulocyte-Macrophage Colony-Stimulating Factor; | 2010 |
11 other studies available for kynurenine and Sepsis
| Article | Year |
|---|---|
Immunometabolic signatures predict risk of progression to sepsis in COVID-19.
Topics: Adult; Area Under Curve; Chemokines; COVID-19; Cytokines; Female; Humans; Kynurenine; Lymphocytes; M | 2021 |
Identification of Biomarkers for the Diagnosis of Sepsis-Associated Acute Kidney Injury and Prediction of Renal Recovery in the Intensive Care Unit.
Topics: Acute Kidney Injury; Biomarkers; Humans; Intensive Care Units; Kidney; Kynurenine; Lactates; Prognos | 2023 |
Interleukin-6 promotes skeletal muscle catabolism by activating tryptophan-indoleamine 2,3-dioxygenase 1-kynurenine pathway during intra-abdominal sepsis.
Topics: Animals; Cytokines; Immunoglobulin G; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kynurenin | 2023 |
Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification.
Topics: Biomarkers; Cell Line; Chromatography, High Pressure Liquid; Endothelial Cells; Fatty Acids; gamma-A | 2018 |
The NRF2‑PGC‑1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, synoviolin, in a cecal ligation/perforation‑induced septic mouse model.
Topics: Animals; Cecum; Disease Models, Animal; Humans; Inflammation; Kynurenine; Mice; NF-E2-Related Factor | 2018 |
Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy.
Topics: Animals; Cecum; Cognitive Dysfunction; Disease Models, Animal; Enzyme Activation; Indoleamine-Pyrrol | 2016 |
Increased plasma kynurenine values and kynurenine-tryptophan ratios after major trauma are early indicators for the development of sepsis.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Injury Severity Score; Kinetics; Kynurenine; Male; M | 2009 |
Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients.
Topics: Adult; Critical Illness; Female; Humans; Kynurenine; Male; Middle Aged; NAD; Renal Insufficiency; Se | 2010 |
An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function.
Topics: Cohort Studies; Cytokines; Endothelium, Vascular; Female; Humans; Immunity; Indoleamine-Pyrrole 2,3, | 2011 |
Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma.
Topics: Adolescent; Adult; Bacteremia; Case-Control Studies; Child; Female; Humans; Indoleamine-Pyrrole 2,3, | 2005 |
Increased cerebrospinal fluid quinolinic acid, kynurenic acid, and L-kynurenine in acute septicemia.
Topics: Acute Disease; Animals; Female; Kynurenic Acid; Kynurenine; Macaca mulatta; Male; Pyridines; Quinoli | 1990 |