ketorolac has been researched along with Ulcer in 5 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.
| Excerpt | Relevance | Reference |
|---|---|---|
| " All compounds were tested for their anti-inflammatory activity using the carrageenan-induced rat paw oedema model and exhibited weak to good activities compared to ketorolac as the reference drug." | 3.76 | Novel substituted and fused pyrrolizine derivatives: synthesis, anti-inflammatory and ulcerogenecity studies. ( Abbas, SE; Awadallah, FM; Gouda, AM; Ibrahim, NA, 2010) |
| "We report the first case of colonic ulceration precipitated by the intramuscular administration of ketorolac." | 3.69 | Colonic ulceration associated with the systemic use of nonsteroidal antiinflammatory medication. ( Buchman, AL; Schwartz, MR, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mishra, A | 1 |
| Veerasamy, R | 1 |
| Jain, PK | 1 |
| Dixit, VK | 1 |
| Agrawal, RK | 1 |
| Abbas, SE | 1 |
| Awadallah, FM | 1 |
| Ibrahim, NA | 1 |
| Gouda, AM | 1 |
| Majumder, R | 1 |
| Datta, M | 1 |
| Banerjee, A | 1 |
| Bandyopadhyay, D | 1 |
| Chattopadhyay, A | 1 |
| Wittkowsky, AK | 1 |
| Reddy, R | 1 |
| Bardy, GH | 1 |
| Buchman, AL | 1 |
| Schwartz, MR | 1 |
5 other studies available for ketorolac and Ulcer
| Article | Year |
|---|---|
Synthesis, characterization and pharmacological evaluation of amide prodrugs of ketorolac.
Topics: Amides; Animals; Humans; Ketorolac; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Prod | 2008 |
Novel substituted and fused pyrrolizine derivatives: synthesis, anti-inflammatory and ulcerogenecity studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Female; Male; Mice; Pyrroles; Rats; Ulcer | 2010 |
Melatonin protects against ketorolac induced gastric mucosal toxic injuries through molecular mechanism associated with the modulation of Arylakylamine N-Acetyltransferase (AANAT) activity.
Topics: Animals; Gastric Mucosa; Ketorolac; Melatonin; Rats; Stomach; Stomach Ulcer; Ulcer | 2023 |
Oral mucosal ulceration from disopyramide.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Fatal Outcome; Humans; Ketorolac; Male; Mouth Disease | 1995 |
Colonic ulceration associated with the systemic use of nonsteroidal antiinflammatory medication.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colonic Diseases; Female; Humans; Injections, Intramu | 1996 |