ketorolac has been researched along with Nausea in 21 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study has attempted to assess postoperative analgesic consumption and nausea and vomiting after general anaesthesia for tonsillectomy using either paracetamol premedication, paracetamol plus a NSAID or intravenous morphine to provide postoperative analgesia." | 9.08 | Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques. ( Mather, SJ; Peutrell, JM, 1995) |
| "To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning." | 9.08 | Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995) |
| " ketorolac and morphine in paediatric outpatients undergoing strabismus surgery." | 9.07 | Comparison of the analgesic and emetic properties of ketorolac and morphine for paediatric outpatient strabismus surgery. ( Lewis, IH; Munro, HM; Reynolds, PI; Riegger, LQ; Wilton, NC, 1994) |
| " Compared to other active drugs, it only showed a lower significant effect compared with granisetron regarding headache change while it showed significantly higher effects only with placebo in both rescue medication needs and headache-free symptoms and valproate in only rescue medication need." | 5.41 | The efficacy and safety of metoclopramide in relieving acute migraine attacks compared with other anti-migraine drugs: a systematic review and network meta-analysis of randomized controlled trials. ( Abd-ElGawad, M; Abdelhay, HM; Abdelmonem, H; Abdelwadoud, GT; Ahmed, AE; Al-Dardery, NM; Alhosini, ANM; Kamel, MA; Mohamed, SW, 2023) |
| " Secondary measures were morphine usage in the first 8 and 24h postoperatively, numeric rating scores (NRS) up to 24h, sedation, nausea, vomiting, respiratory depression, pruritus and bleeding complications." | 5.24 | Intraoperative ketorolac dose of 15mg versus the standard 30mg on early postoperative pain after spine surgery: A randomized, blinded, non-inferiority trial. ( Davis, M; De Guzman, C; Duttchen, KM; Lo, A; McLuckie, D; Roman-Smith, H; Walker, A, 2017) |
| " This study has attempted to assess postoperative analgesic consumption and nausea and vomiting after general anaesthesia for tonsillectomy using either paracetamol premedication, paracetamol plus a NSAID or intravenous morphine to provide postoperative analgesia." | 5.08 | Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques. ( Mather, SJ; Peutrell, JM, 1995) |
| "To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning." | 5.08 | Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995) |
| "05 mg kg(-1) +droperidol 20 microg kg(-1) was given as prophylaxis for postoperative pain and emesis, respectively." | 5.08 | Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy. ( Aasbø, V; Buanes, T; Grøgaard, B; Mjåland, O; Raeder, JC, 1998) |
| " ketorolac and morphine in paediatric outpatients undergoing strabismus surgery." | 5.07 | Comparison of the analgesic and emetic properties of ketorolac and morphine for paediatric outpatient strabismus surgery. ( Lewis, IH; Munro, HM; Reynolds, PI; Riegger, LQ; Wilton, NC, 1994) |
| " The purpose of our investigation was to examine the intraosseous administration of a multimodal pain regimen comprised of morphine and ketorolac during total knee arthroplasty with regard to immediate and 2-week postoperative pain, opioid pain medication intake, and nausea levels." | 4.31 | A multimodal intraosseous infusion of morphine and ketorolac decreases early postoperative pain and opioid consumption following total knee arthroplasty. ( Clyburn, TA; Incavo, SJ; Lambert, BS; Laurita, J; McNamara, CA; Park, KJ; Sullivan, TC, 2023) |
| " For management of postoperative muscle spasm, an intravenous benzodiazepine was used (diazepam 0." | 3.69 | Pain management for children following selective dorsal rhizotomy. ( Geiduschek, JM; Haberkern, CM; Hays, RM; Jacobson, LE; McLaughlin, JF; Roberts, TS, 1994) |
| "In treatment of refractory migraine headache, CAMBIA® may provide similar benefits as IM ketorolac without increasing the risk of treatment failure, major bleeding, or cardiovascular events." | 2.94 | IM ketorolac vs diclofenac potassium powder for oral solution for the acute treatment of severe migraine: a randomized controlled trial. ( Cheng, J; Engel, ER, 2020) |
| "Poor postoperative pain control is frequently associated with complications and delayed discharge from a hospital." | 2.80 | Comparing parecoxib and ketorolac as preemptive analgesia in patients undergoing posterior lumbar spinal fusion: a prospective randomized double-blinded placebo-controlled trial. ( Cheewakidakarn, J; Nimmaanrat, S; Siribumrungwong, K; Tangtrakulwanich, B, 2015) |
| "Ketorolac tromethamine is a well-tolerated, effective medication in the treatment of acute biliary colic." | 2.70 | Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic. ( Henderson, SO; Newton, E; Swadron, S, 2002) |
| "Postoperative pain was assessed using a visual analogue score (VAS) on 3 separate occasions in recovery." | 2.67 | Intramuscular ketorolac for postoperative analgesia following laparoscopic sterilisation. ( Duffy, BL; Shapiro, MH, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (57.14) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 4 (19.05) | 2.80 |
| Authors | Studies |
|---|---|
| Abdelmonem, H | 1 |
| Abdelhay, HM | 1 |
| Abdelwadoud, GT | 1 |
| Alhosini, ANM | 1 |
| Ahmed, AE | 1 |
| Mohamed, SW | 1 |
| Al-Dardery, NM | 1 |
| Abd-ElGawad, M | 1 |
| Kamel, MA | 1 |
| McNamara, CA | 1 |
| Laurita, J | 1 |
| Lambert, BS | 1 |
| Sullivan, TC | 1 |
| Clyburn, TA | 1 |
| Incavo, SJ | 1 |
| Park, KJ | 1 |
| Engel, ER | 1 |
| Cheng, J | 1 |
| Hatami, M | 1 |
| Talebi, M | 1 |
| Heiranizadeh, N | 1 |
| Vaziribozorg, S | 1 |
| Duttchen, KM | 1 |
| Lo, A | 1 |
| Walker, A | 1 |
| McLuckie, D | 1 |
| De Guzman, C | 1 |
| Roman-Smith, H | 1 |
| Davis, M | 1 |
| Singh, SI | 1 |
| Rehou, S | 1 |
| Marmai, KL | 1 |
| Jones, APM | 1 |
| Siribumrungwong, K | 1 |
| Cheewakidakarn, J | 1 |
| Tangtrakulwanich, B | 1 |
| Nimmaanrat, S | 1 |
| Gasanova, I | 1 |
| Grant, E | 1 |
| Way, M | 1 |
| Rosero, EB | 1 |
| Joshi, GP | 1 |
| Henderson, SO | 1 |
| Swadron, S | 1 |
| Newton, E | 1 |
| Mather, SJ | 1 |
| Peutrell, JM | 1 |
| Watcha, MF | 1 |
| White, PF | 1 |
| Bradford, TH | 1 |
| Robertson, K | 1 |
| Norman, PF | 1 |
| Meeks, GR | 1 |
| Shapiro, MH | 1 |
| Duffy, BL | 1 |
| Munro, HM | 1 |
| Riegger, LQ | 1 |
| Reynolds, PI | 1 |
| Wilton, NC | 1 |
| Lewis, IH | 1 |
| Geiduschek, JM | 1 |
| Haberkern, CM | 1 |
| McLaughlin, JF | 1 |
| Jacobson, LE | 1 |
| Hays, RM | 1 |
| Roberts, TS | 1 |
| Monagle, J | 1 |
| Wongprasartsuk, P | 1 |
| Shearer, W | 1 |
| Stein, A | 1 |
| Ben Dov, D | 1 |
| Finkel, B | 1 |
| Mecz, Y | 1 |
| Kitzes, R | 1 |
| Lurie, A | 1 |
| Turner, GA | 1 |
| Anson, N | 1 |
| Williamson, R | 1 |
| Reinhart, DJ | 1 |
| Goldberg, ME | 1 |
| Roth, JV | 1 |
| Dua, R | 1 |
| Nevo, I | 1 |
| Klein, KW | 1 |
| Torjman, M | 1 |
| Vekeman, D | 1 |
| Milford, MA | 1 |
| Paluch, TA | 1 |
| Raeder, JC | 1 |
| Mjåland, O | 1 |
| Aasbø, V | 1 |
| Grøgaard, B | 1 |
| Buanes, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| IM Ketorolac vs Diclofenac Potassium Powder for Oral Solution (Cambia) for the Acute Treatment of Severe Migraine[NCT02664116] | Phase 4 | 40 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | ||
| Effect of Low-dose Epidural Morphine Combined With Single-injection Femoral Nerve Block on Postoperative Analgesia in Patients After Total Knee Arthroplasty[NCT03203967] | 110 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| Intravenous Versus Oral Acetaminophen for Postoperative Pain Control After Cesarean Delivery[NCT02487303] | 148 participants (Actual) | Interventional | 2015-03-17 | Completed | |||
| Comparing the Efficacy of Parecoxib and Ketorolac as Preemptive Analgesia in Patients Undergoing Posterior Lumbar Spinal Fusion[NCT01859585] | Phase 4 | 96 participants (Actual) | Interventional | 2011-03-31 | Completed | ||
| Ultrasound-guided Transversus Abdominis Plane Block After Abdominal Hysterectomy: a Prospective Randomized Controlled Trial[NCT01153503] | 75 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| Bilateral Transversus Abdominis Plane Block With or Without Magnesium for Total Abdominal Hysterectomy With or Without Salpingo-oophorectomy: a Randomized Controlled Trial[NCT02680626] | Phase 4 | 86 participants (Actual) | Interventional | 2016-01-31 | Terminated (stopped due to Pfannenstiel hysterectomies are now rarely performed so cannot recruit eligible patients) | ||
| Assessment of the Analgesic Efficacy of Intravenous Ibuprofen in Biliary Colic[NCT02268955] | 22 participants (Actual) | Interventional | 2014-09-09 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cumulative opiate consumption (IV morphine equivalents) (NCT02487303)
Timeframe: 24 hours
| Intervention | mg (Mean) |
|---|---|
| Acetaminophen Intravenous | 2.9 |
| Acetaminophen Oral | 3.8 |
| No Acetaminophen | 5.7 |
Time patient meets discharge criteria will be recorded (NCT02487303)
Timeframe: 24 hours postoperative
| Intervention | hours (Mean) |
|---|---|
| Acetaminophen Intravenous | 48.4 |
| Acetaminophen Oral | 48.6 |
| No Acetaminophen | 50.5 |
Time to first opiate pain medicine requested by patient (NCT02487303)
Timeframe: 48 hours
| Intervention | hours (Mean) |
|---|---|
| Acetaminophen Intravenous | 25.3 |
| Acetaminophen Oral | 24.0 |
| No Acetaminophen | 21.3 |
"Visual Analog Scale (VAS) pain assessment with ambulation. The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between no pain and worst pain. For pain intensity, the scale is most commonly anchored by no pain (score of 0) and pain as bad as it could be or worst imaginable pain (score of 100 [100-mm scale]) ." (NCT02487303)
Timeframe: 24 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Acetaminophen Intravenous | 37.8 |
| Acetaminophen Oral | 44.3 |
| No Acetaminophen | 50.8 |
Morphine consumption over the first 24 hours (NCT01153503)
Timeframe: 24 hours post surgery
| Intervention | mg (Mean) |
|---|---|
| Ketorolac 30 mg, IV + TAP Block | 38.4 |
| TAP Block | 38.6 |
| Ketorolac 30 mg | 42.6 |
Pain is measured on a visual analog scale 0=no pain and 10=worst pain imaginable. (NCT02268955)
Timeframe: 120 minutes post medication administration
| Intervention | score on a scale (Median) |
|---|---|
| Control Group: Adults Age 18-55 Years | 3.0 |
| IV Ibuprofen: Adults Age 18-55 Years | 0.3 |
2 reviews available for ketorolac and Nausea
| Article | Year |
|---|---|
The efficacy and safety of metoclopramide in relieving acute migraine attacks compared with other anti-migraine drugs: a systematic review and network meta-analysis of randomized controlled trials.
Topics: Chlorpromazine; Granisetron; Headache; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Nausea | 2023 |
New antiemetic drugs.
Topics: Ambulatory Surgical Procedures; Anesthesia, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; An | 1995 |
16 trials available for ketorolac and Nausea
| Article | Year |
|---|---|
IM ketorolac vs diclofenac potassium powder for oral solution for the acute treatment of severe migraine: a randomized controlled trial.
Topics: Acute Disease; Administration, Oral; Adult; Cyclooxygenase Inhibitors; Diclofenac; Double-Blind Meth | 2020 |
The Effect of Perianal Tramadol Infiltration on Postoperative Pain Following Hemorrhoidectomy.
Topics: Adult; Aged; Analgesics, Opioid; Anesthesia, Local; Anesthetics, Local; Anti-Inflammatory Agents, No | 2022 |
Intraoperative ketorolac dose of 15mg versus the standard 30mg on early postoperative pain after spine surgery: A randomized, blinded, non-inferiority trial.
Topics: Adult; Aged; Analgesics, Opioid; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double | 2017 |
The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroid | 2013 |
The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroid | 2013 |
The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroid | 2013 |
The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial.
Topics: Adolescent; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroid | 2013 |
Comparing parecoxib and ketorolac as preemptive analgesia in patients undergoing posterior lumbar spinal fusion: a prospective randomized double-blinded placebo-controlled trial.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; | 2015 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract Diseases; Colic; D | 2002 |
Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recove | 1995 |
Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning.
Topics: Analgesics, Non-Narcotic; Bupivacaine; Combined Modality Therapy; Female; Humans; Ketorolac; Laparos | 1995 |
Intramuscular ketorolac for postoperative analgesia following laparoscopic sterilisation.
Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Double-Blind Method; Female; Humans; Injections, I | 1994 |
Comparison of the analgesic and emetic properties of ketorolac and morphine for paediatric outpatient strabismus surgery.
Topics: Ambulatory Surgical Procedures; Analgesics; Child; Child, Preschool; Double-Blind Method; Female; Hu | 1994 |
Ketorolac versus fentanyl for gynaecological day-case surgery.
Topics: Adult; Ambulatory Surgical Procedures; Anesthesia; Female; Fentanyl; Genital Diseases, Female; Human | 1993 |
Single-dose intramuscular ketorolac versus diclofenac for pain management in renal colic.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Colic; Diclofenac; Double-Blind Method; Female | 1996 |
A comparison of intramuscular ketorolac with indomethacin suppositories in the treatment of pain after oral surgery.
Topics: Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethac | 1996 |
Transdermal fentanyl system plus im ketorolac for the treatment of postoperative pain.
Topics: Administration, Cutaneous; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 1997 |
Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy.
Topics: Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthetics, D | 1998 |
3 other studies available for ketorolac and Nausea
| Article | Year |
|---|---|
A multimodal intraosseous infusion of morphine and ketorolac decreases early postoperative pain and opioid consumption following total knee arthroplasty.
Topics: Analgesics, Opioid; Arthroplasty, Replacement, Knee; Humans; Infusions, Intraosseous; Ketorolac; Mor | 2023 |
Pain management for children following selective dorsal rhizotomy.
Topics: Adolescent; Adult; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Bupiva | 1994 |
Ambulatory laparoscopic fundoplication.
Topics: Adult; Aged; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Opioid; Anestheti | 1997 |