ketorolac has been researched along with Emesis in 23 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study has attempted to assess postoperative analgesic consumption and nausea and vomiting after general anaesthesia for tonsillectomy using either paracetamol premedication, paracetamol plus a NSAID or intravenous morphine to provide postoperative analgesia." | 9.08 | Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques. ( Mather, SJ; Peutrell, JM, 1995) |
| "Fifty-four ASA I and II children 1 to 10 yr of age undergoing strabismus surgery were randomized to receive in a double-blind fashion intravenous ketorolac (0." | 9.08 | The effects of ketorolac and fentanyl on postoperative vomiting and analgesic requirements in children undergoing strabismus surgery. ( Guarnieri, KM; Mendel, HG; Sundt, LM; Torjman, MC, 1995) |
| " ketorolac and morphine in paediatric outpatients undergoing strabismus surgery." | 9.07 | Comparison of the analgesic and emetic properties of ketorolac and morphine for paediatric outpatient strabismus surgery. ( Lewis, IH; Munro, HM; Reynolds, PI; Riegger, LQ; Wilton, NC, 1994) |
| "For children undergoing inguinal surgery, the administration of a single dose of intravenous morphine after the induction of anesthesia smooths emergence from anesthesia as assessed by improved cooperation and sedation in the PACU, decreases the need for postoperative analgesics, but increases the incidence of vomiting in the first 24 h after surgery." | 9.07 | A single dose of morphine sulfate increases the incidence of vomiting after outpatient inguinal surgery in children. ( Nicolson, SC; Schreiner, MS; Weinstein, MS, 1994) |
| "Cyclic vomiting is a rare syndrome that over the years has variously been ascribed to psychogenic causes, sensory seizures, abdominal migraine, and more recently, to mechanical or electrical disturbances in gastric physiology." | 5.29 | Cyclic vomiting: association with multiple homeostatic abnormalities and response to ketorolac. ( Pasricha, PJ; Ravich, WJ; Saudek, CD; Schuster, MM; Wand, G, 1996) |
| " Secondary measures were morphine usage in the first 8 and 24h postoperatively, numeric rating scores (NRS) up to 24h, sedation, nausea, vomiting, respiratory depression, pruritus and bleeding complications." | 5.24 | Intraoperative ketorolac dose of 15mg versus the standard 30mg on early postoperative pain after spine surgery: A randomized, blinded, non-inferiority trial. ( Davis, M; De Guzman, C; Duttchen, KM; Lo, A; McLuckie, D; Roman-Smith, H; Walker, A, 2017) |
| " This study has attempted to assess postoperative analgesic consumption and nausea and vomiting after general anaesthesia for tonsillectomy using either paracetamol premedication, paracetamol plus a NSAID or intravenous morphine to provide postoperative analgesia." | 5.08 | Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques. ( Mather, SJ; Peutrell, JM, 1995) |
| "Fifty-four ASA I and II children 1 to 10 yr of age undergoing strabismus surgery were randomized to receive in a double-blind fashion intravenous ketorolac (0." | 5.08 | The effects of ketorolac and fentanyl on postoperative vomiting and analgesic requirements in children undergoing strabismus surgery. ( Guarnieri, KM; Mendel, HG; Sundt, LM; Torjman, MC, 1995) |
| "To compare the incidence of vomiting following codeine or ketorolac for tonsillectomy in children." | 5.08 | Preoperative ketorolac increases bleeding after tonsillectomy in children. ( MacNeill, HB; Reid, CW; Rhine, EJ; Roberts, DW; Splinter, WM, 1996) |
| "This prospective, randomized double-blind study was conducted to examine the effect of intraoperative opioid (fentanyl) supplementation on postoperative analgesia, emesis, and recovery in ambulatory patients receiving propofol-nitrous oxide anesthesia." | 5.08 | Recovery after propofol with and without intraoperative fentanyl in patients undergoing ambulatory gynecologic laparoscopy. ( Aasen, M; Frey, K; Pappas, AL; Slogoff, S; Sukhani, R; Vazquez, J, 1996) |
| "05 mg kg(-1) +droperidol 20 microg kg(-1) was given as prophylaxis for postoperative pain and emesis, respectively." | 5.08 | Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy. ( Aasbø, V; Buanes, T; Grøgaard, B; Mjåland, O; Raeder, JC, 1998) |
| " ketorolac and morphine in paediatric outpatients undergoing strabismus surgery." | 5.07 | Comparison of the analgesic and emetic properties of ketorolac and morphine for paediatric outpatient strabismus surgery. ( Lewis, IH; Munro, HM; Reynolds, PI; Riegger, LQ; Wilton, NC, 1994) |
| "For children undergoing inguinal surgery, the administration of a single dose of intravenous morphine after the induction of anesthesia smooths emergence from anesthesia as assessed by improved cooperation and sedation in the PACU, decreases the need for postoperative analgesics, but increases the incidence of vomiting in the first 24 h after surgery." | 5.07 | A single dose of morphine sulfate increases the incidence of vomiting after outpatient inguinal surgery in children. ( Nicolson, SC; Schreiner, MS; Weinstein, MS, 1994) |
| " For management of postoperative muscle spasm, an intravenous benzodiazepine was used (diazepam 0." | 3.69 | Pain management for children following selective dorsal rhizotomy. ( Geiduschek, JM; Haberkern, CM; Hays, RM; Jacobson, LE; McLaughlin, JF; Roberts, TS, 1994) |
| "Postoperative pain was managed with patient-controlled analgesia using ketorolac." | 2.78 | Is pain after TKA better with periarticular injection or intrathecal morphine? ( Kanitnate, S; Manuwong, S; Panichkul, P; Tammachote, N; Yakumpor, T, 2013) |
| "Postoperative pain was assessed by self-report 1." | 2.69 | Analgesic efficacy and safety of preoperative versus postoperative ketorolac in paediatric tonsillectomy. ( Ostergaard, D; Rømsing, J; Valentin, N; Walther-Larsen, S, 1998) |
| "Postoperative pain was assessed using a visual analogue score (VAS) on 3 separate occasions in recovery." | 2.67 | Intramuscular ketorolac for postoperative analgesia following laparoscopic sterilisation. ( Duffy, BL; Shapiro, MH, 1994) |
| "Postoperative pain was evaluated by the child using a 10-cm linear visual analog scale (VAS) and by a blinded observer using both a VAS and an objective pain scale (OPS) in the postanesthesia care unit (PACU)." | 2.67 | Comparison of ketorolac and morphine as adjuvants during pediatric surgery. ( Jones, MB; Lagueruela, RG; Schweiger, C; Watcha, MF; White, PF, 1992) |
| "Ketorolac was administered to 11." | 1.48 | Pain Management for Nonsyndromic Craniosynostosis: Adequate Analgesia in a Pediatric Cohort? ( Cho, R; Dorafshar, AH; Faateh, M; Kattail, D; Lopez, J; Macmillan, A; Musavi, L; Pedreira, R, 2018) |
| "Cyclic vomiting is a rare syndrome that over the years has variously been ascribed to psychogenic causes, sensory seizures, abdominal migraine, and more recently, to mechanical or electrical disturbances in gastric physiology." | 1.29 | Cyclic vomiting: association with multiple homeostatic abnormalities and response to ketorolac. ( Pasricha, PJ; Ravich, WJ; Saudek, CD; Schuster, MM; Wand, G, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (82.61) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duttchen, KM | 1 |
| Lo, A | 1 |
| Walker, A | 1 |
| McLuckie, D | 1 |
| De Guzman, C | 1 |
| Roman-Smith, H | 1 |
| Davis, M | 1 |
| Kattail, D | 1 |
| Macmillan, A | 1 |
| Musavi, L | 1 |
| Pedreira, R | 1 |
| Faateh, M | 1 |
| Cho, R | 1 |
| Lopez, J | 1 |
| Dorafshar, AH | 1 |
| Gasanova, I | 1 |
| Grant, E | 1 |
| Way, M | 1 |
| Rosero, EB | 1 |
| Joshi, GP | 1 |
| Tammachote, N | 1 |
| Kanitnate, S | 1 |
| Manuwong, S | 1 |
| Yakumpor, T | 1 |
| Panichkul, P | 1 |
| Gunter, JB | 1 |
| Varughese, AM | 1 |
| Harrington, JF | 1 |
| Wittkugel, EP | 1 |
| Patankar, SS | 1 |
| Matar, MM | 1 |
| Lowe, EE | 1 |
| Myer, CM | 1 |
| Willging, JP | 1 |
| Mather, SJ | 1 |
| Peutrell, JM | 1 |
| Watcha, MF | 2 |
| White, PF | 2 |
| Mendel, HG | 1 |
| Guarnieri, KM | 1 |
| Sundt, LM | 1 |
| Torjman, MC | 1 |
| Shapiro, MH | 1 |
| Duffy, BL | 1 |
| Munro, HM | 2 |
| Riegger, LQ | 2 |
| Reynolds, PI | 2 |
| Wilton, NC | 1 |
| Lewis, IH | 1 |
| Geiduschek, JM | 1 |
| Haberkern, CM | 1 |
| McLaughlin, JF | 1 |
| Jacobson, LE | 1 |
| Hays, RM | 1 |
| Roberts, TS | 1 |
| Weinstein, MS | 1 |
| Nicolson, SC | 1 |
| Schreiner, MS | 1 |
| Monagle, J | 1 |
| Wongprasartsuk, P | 1 |
| Shearer, W | 1 |
| Stein, A | 1 |
| Ben Dov, D | 1 |
| Finkel, B | 1 |
| Mecz, Y | 1 |
| Kitzes, R | 1 |
| Lurie, A | 1 |
| Splinter, WM | 1 |
| Rhine, EJ | 1 |
| Roberts, DW | 1 |
| Reid, CW | 1 |
| MacNeill, HB | 1 |
| Pasricha, PJ | 1 |
| Schuster, MM | 1 |
| Saudek, CD | 1 |
| Wand, G | 1 |
| Ravich, WJ | 1 |
| Sukhani, R | 1 |
| Vazquez, J | 1 |
| Pappas, AL | 1 |
| Frey, K | 1 |
| Aasen, M | 1 |
| Slogoff, S | 1 |
| Turner, GA | 1 |
| Anson, N | 1 |
| Williamson, R | 1 |
| Reinhart, DJ | 1 |
| Goldberg, ME | 1 |
| Roth, JV | 1 |
| Dua, R | 1 |
| Nevo, I | 1 |
| Klein, KW | 1 |
| Torjman, M | 1 |
| Vekeman, D | 1 |
| Raeder, JC | 1 |
| Mjåland, O | 1 |
| Aasbø, V | 1 |
| Grøgaard, B | 1 |
| Buanes, T | 1 |
| Rømsing, J | 1 |
| Ostergaard, D | 1 |
| Walther-Larsen, S | 1 |
| Valentin, N | 1 |
| Jones, MB | 1 |
| Lagueruela, RG | 1 |
| Schweiger, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ultrasound-guided Transversus Abdominis Plane Block After Abdominal Hysterectomy: a Prospective Randomized Controlled Trial[NCT01153503] | 75 participants (Actual) | Interventional | 2010-04-30 | Completed | |||
| Bilateral Transversus Abdominis Plane Block With or Without Magnesium for Total Abdominal Hysterectomy With or Without Salpingo-oophorectomy: a Randomized Controlled Trial[NCT02680626] | Phase 4 | 86 participants (Actual) | Interventional | 2016-01-31 | Terminated (stopped due to Pfannenstiel hysterectomies are now rarely performed so cannot recruit eligible patients) | ||
| A Pilot Study Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT02973958] | Phase 1 | 30 participants (Actual) | Interventional | 2017-02-01 | Completed | ||
| A Randomized Control Trial Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision[NCT04646967] | Phase 2 | 100 participants (Anticipated) | Interventional | 2022-11-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Morphine consumption over the first 24 hours (NCT01153503)
Timeframe: 24 hours post surgery
| Intervention | mg (Mean) |
|---|---|
| Ketorolac 30 mg, IV + TAP Block | 38.4 |
| TAP Block | 38.6 |
| Ketorolac 30 mg | 42.6 |
1 review available for ketorolac and Emesis
| Article | Year |
|---|---|
New antiemetic drugs.
Topics: Ambulatory Surgical Procedures; Anesthesia, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; An | 1995 |
18 trials available for ketorolac and Emesis
| Article | Year |
|---|---|
Intraoperative ketorolac dose of 15mg versus the standard 30mg on early postoperative pain after spine surgery: A randomized, blinded, non-inferiority trial.
Topics: Adult; Aged; Analgesics, Opioid; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Double | 2017 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Ultrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Topics: Abdominal Muscles; Acetaminophen; Adult; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; An | 2013 |
Is pain after TKA better with periarticular injection or intrathecal morphine?
Topics: Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Antipruritics; Arthr | 2013 |
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B | 1995 |
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B | 1995 |
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B | 1995 |
Recovery and complications after tonsillectomy in children: a comparison of ketorolac and morphine.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recovery Period; Child, Preschool; Double-B | 1995 |
Postoperative morphine requirements, nausea and vomiting following anaesthesia for tonsillectomy. Comparison of intravenous morphine and non-opioid analgesic techniques.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recove | 1995 |
The effects of ketorolac and fentanyl on postoperative vomiting and analgesic requirements in children undergoing strabismus surgery.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthesia; Child; Child, P | 1995 |
Intramuscular ketorolac for postoperative analgesia following laparoscopic sterilisation.
Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Double-Blind Method; Female; Humans; Injections, I | 1994 |
Comparison of the analgesic and emetic properties of ketorolac and morphine for paediatric outpatient strabismus surgery.
Topics: Ambulatory Surgical Procedures; Analgesics; Child; Child, Preschool; Double-Blind Method; Female; Hu | 1994 |
A single dose of morphine sulfate increases the incidence of vomiting after outpatient inguinal surgery in children.
Topics: Age Factors; Ambulatory Surgical Procedures; Analgesics; Child; Child, Preschool; Double-Blind Metho | 1994 |
Ketorolac versus fentanyl for gynaecological day-case surgery.
Topics: Adult; Ambulatory Surgical Procedures; Anesthesia; Female; Fentanyl; Genital Diseases, Female; Human | 1993 |
Single-dose intramuscular ketorolac versus diclofenac for pain management in renal colic.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Colic; Diclofenac; Double-Blind Method; Female | 1996 |
Preoperative ketorolac increases bleeding after tonsillectomy in children.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anesthesia, Inhalation; Anesthet | 1996 |
Recovery after propofol with and without intraoperative fentanyl in patients undergoing ambulatory gynecologic laparoscopy.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Reco | 1996 |
A comparison of intramuscular ketorolac with indomethacin suppositories in the treatment of pain after oral surgery.
Topics: Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Indomethac | 1996 |
Transdermal fentanyl system plus im ketorolac for the treatment of postoperative pain.
Topics: Administration, Cutaneous; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, N | 1997 |
Desflurane versus propofol maintenance for outpatient laparoscopic cholecystectomy.
Topics: Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthetics, D | 1998 |
Analgesic efficacy and safety of preoperative versus postoperative ketorolac in paediatric tonsillectomy.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; | 1998 |
Comparison of ketorolac and morphine as adjuvants during pediatric surgery.
Topics: Adjuvants, Anesthesia; Adolescent; Analgesics; Anesthesia, General; Child; Child, Preschool; Double- | 1992 |
4 other studies available for ketorolac and Emesis
| Article | Year |
|---|---|
Pain Management for Nonsyndromic Craniosynostosis: Adequate Analgesia in a Pediatric Cohort?
Topics: Age Factors; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Body Weight; Child, Preschool; | 2018 |
Pain management for children following selective dorsal rhizotomy.
Topics: Adolescent; Adult; Analgesia; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Bupiva | 1994 |
Ketorolac and strabismus surgery.
Topics: Analgesics, Non-Narcotic; Humans; Ketorolac; Postoperative Complications; Strabismus; Tolmetin; Vomi | 1996 |
Cyclic vomiting: association with multiple homeostatic abnormalities and response to ketorolac.
Topics: Adrenocorticotropic Hormone; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diabetes Mellitus, Type | 1996 |