ketorolac has been researched along with Ache in 159 studies
Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this prospective, double-blind, randomized controlled trial was to compare the effect of oral premedication of meloxicam, ketorolac, dexamethasone, ibuprofen, or placebo on the success of inferior alveolar nerve blocks (IANB) of mandibular posterior teeth in patients experiencing symptomatic irreversible pulpitis." | 9.69 | Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial. ( Elnaghy, AM; Elsaka, SE; Elshazli, AH, 2023) |
| "Intravenous ketorolac is commonly used for treating migraine headaches in children." | 9.51 | Intranasal ketorolac versus intravenous ketorolac for treatment of migraine headaches in children: A randomized clinical trial. ( Babineau, SE; Carter, RC; Chernick, LS; Dayan, PS; DePeter, KC; Fan, W; Friedman, BW; Gonzalez, AE; Kwok, MY; Lubell, TR; McLaren, SH; Roskind, CG; Tsze, DS, 2022) |
| "To compare pain and the need for the opioid fentanyl use associated with the administration of phenylephrine 1." | 9.51 | Pain control and reduction of opioid use associated with intracameral phenylephrine1.0%-ketorolac 0.3% administered during cataract surgery. ( Donnenfeld, ED; Mychajlyszyn, A; Mychajlyszyn, D; Stein, R, 2022) |
| " The purpose of this study was to evaluate the effects of adding dexamethasone to ketorolac on pain control in acute renal colic." | 9.51 | Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial. ( Farrokhi, E; Haghighi, R; Hosseini, SS; Lotfabadi, P; Rameshrad, M; Razi, A; Saadati, H, 2022) |
| "Our study found that ketorolac injections resulted in inferior pain reduction, functional score and grip improvement than triamcinolone injection in patients with radial styloid tenosynovitis." | 9.51 | Comparison of the effect of ketorolac versus triamcinolone acetonide injections for the treatment of de Quervain's tenosynovitis: a double-blind randomized controlled trial. ( Chuaychoosakoon, C; Fongsri, W; Suwannaphisit, S; Suwanno, P, 2022) |
| "In this double-blind clinical trial study, the patients with renal colic pain were randomly divided into 2 groups; Group I received an intravenous infusion of 30 mg of Ketorolac and normal saline as placebo, Group II 50 mg/kg magnesium sulphate 50%/100 ml normal plus 30 mg of Ketorolac." | 9.30 | Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study. ( Aryan, A; Fahimi, MA; Maleki Verki, M; Motamed, H; Porozan, S, 2019) |
| "To compare the safety and efficacy of xylocaine gel and ketorolac as opioid-sparing analgesia compared with pethidine for shock wave lithotripsy (SWL) pain." | 9.30 | Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial. ( Abol-Enein, H; Atwa, AM; El-Assmy, A; Elbaset, MA; Fadallah, M; Ghobrial, FK; Hashem, A; Laymon, M; Sheir, KZ, 2019) |
| "To evaluate intramuscular ketorolac compared with placebo saline injection for pain control with intrauterine device (IUD) placement." | 9.20 | Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial. ( Mody, SK; Ngo, LL; Ward, KK, 2015) |
| "Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain." | 9.19 | Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014) |
| "What's known on the subject? and What does the study add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal prostate biopsy, but not pain due to periprostatic infiltration." | 9.16 | Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2012) |
| "To determine the efficacy of preoperative intravenous ketorolac in reducing intraoperative and postoperative pain and improving patient satisfaction in patients undergoing single-stage adjustable strabismus surgery." | 9.15 | The efficacy of intravenous ketorolac for pain relief in single-stage adjustable strabismus surgery: a prospective, randomized, placebo-controlled trial. ( Bae, SJ; Chang, JH; Chung, SA; Kim, WK; Lee, JB; Rhiu, S, 2011) |
| "Topical ketorolac tromethamine usage is no more effective than artificial tears for pain relief during posterior segment laser procedures in proliferative diabetic retinopathy patients." | 9.12 | Topical ketorolac 0.5% for ocular pain relief during scatter laser photocoagulation with 532 nm green laser. ( Esgin, H; Samut, HS, 2006) |
| "We compare the effectiveness of intravenous ketorolac and intravenous prochlorperazine in the treatment of pediatric migraine headaches." | 9.11 | Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac. ( Anderson, AC; Brousseau, DC; Duffy, SJ; Linakis, JG, 2004) |
| " 15 and 30 mg ketorolac reduces pain following propofol injection." | 9.10 | Effect of pretreatment with ketorolac on propofol injection pain. ( Buerkle, H; Chou, AK; Huang, YW; Lee, TH; Lin, CR; Lin, SH; Lu, CY; Muhammad, R; Yang, LC, 2002) |
| "Patients receiving ketorolac and those receiving placebo were of similar age, weight, gender, number of prior ED visits, number of prior hospital admissions, duration of pain prior to presentation, and initial pain score." | 9.09 | Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis. ( Givens, TG; Hardwick, WE; King, WD; Lawley, D; Monroe, KW, 1999) |
| "We performed a randomised, double-blind, prospective trial to discover whether intravenous ketorolac 10 mg made up to 2 ml with saline, with or without venous occlusion for 2 min, reduces the pain on injection of propofol." | 9.09 | Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol. ( Barkshire, KF; Dexter, T; Yull, DN, 2000) |
| "To investigate the cost effectiveness of intravenous ketorolac compared with intravenous morphine in relieving pain after blunt limb injury in an accident and emergency department." | 9.09 | Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. ( Cheung, NK; Cocks, RA; Jacobs, P; Lam, PK; Ng, YC; Rainer, TH; Tam, M; Wong, R, 2000) |
| "To evaluate the efficacy of IM ketorolac versus that of oral ibuprofen in acute musculoskeletal pain." | 9.08 | Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995) |
| "To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning." | 9.08 | Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995) |
| "Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion." | 9.08 | Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995) |
| "25% bupivacaine without epinephrine to those of normal saline on chest tube removal pain in cardiothoracic surgery patients." | 9.08 | Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial. ( Puntillo, KA, 1996) |
| "A randomised, double-blind, controlled trial was undertaken to compare three different methods of reducing pain during the intravenous injection of propofol." | 9.08 | The effect of pretreatment with ketorolac on pain during intravenous injection of propofol. ( Power, I; Smith, AJ, 1996) |
| "To determine if a single dose of intramuscular ketorolac given on presentation to the emergency department has a narcotic-sparing effect in adult patients with sickle cell vaso-occlusive crisis pain." | 9.07 | Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992) |
| "Ketorolac is a member of the pyrrolo-pyrrole group of NSAIDs, and has been available in several formulations for some time, for the treatment of pain." | 8.88 | Intranasal ketorolac: for short-term pain management. ( Garnock-Jones, KP, 2012) |
| "In May 2022, we conducted a search of major databases, MEDLINE (PubMed and Ovid), Embase, Epistemonikos, and the Cochrane Database of Systematic Reviews to identify eligible SRs on ketorolac for perioperative pain." | 8.12 | An analysis of harms reporting in systematic reviews regarding ketorolac for management of perioperative pain. ( Flores, H; Garrett, M; Kee, M; Magee, T; Modi, J; Roberts, W; Rucker, B; Vassar, M; Wise, A, 2022) |
| "To assess the effectiveness of intracameral phenylephrine-ketorolac during cataract surgery compared with postoperative topical steroids in reducing the incidence of postoperative clinical cystoid macular edema (CME) confirmed via optical coherence tomography (OCT), breakthrough iritis, pain, and photophobia." | 7.96 | Effect of intracameral phenylephrine 1.0%-ketorolac 0.3% on postoperative cystoid macular edema, iritis, pain, and photophobia after cataract surgery. ( Bedi, R; Visco, DM, 2020) |
| " All patients received ketorolac and acetaminophen with codeine for pain, and early in the series 7 patients received morphine." | 7.75 | Contemporary open ureteral reimplantation without morphine: assessment of pain and outcomes. ( Chamie, K; Chi, A; Hu, B; Keegan, KA; Kurzrock, EA, 2009) |
| "This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain." | 7.73 | Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005) |
| "We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 7.70 | Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998) |
| "To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain." | 7.68 | Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993) |
| "Ketorolac tromethamine was not superior to FM or PB in reducing lameness using a HBS model." | 6.94 | Ketorolac Is Not More Effective Than Flunixin Meglumine or Phenylbutazone in Reducing Foot Pain in Horses. ( Brunner, TJ; Cooper, BR; Davern, AJ; Grady, SE; Lescun, TB; Moore, GE; Taylor, SD, 2020) |
| "Ketorolac or vehicle was instilled before the injection, and pain perception was recorded on a 0 to 100 Visual Analog Scale (VAS) immediately after the intravitreal administration." | 6.77 | Effect of ketorolac 0.5% drops on patients' pain perception during intravitreal injection procedure. ( Beredima, E; Georgakopoulos, CD; Makri, OE; Pharmakakis, NM; Vasilakis, PT, 2012) |
| "Pretreatment with parecoxib or ketorolac reduced the postinfusion area of pinprick hyperalgesia (P < 0." | 6.76 | Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans. ( Draegni, T; Heyerdahl, F; Lenz, H; Raeder, J; Schmelz, M; Stubhaug, A, 2011) |
| "ketorolac (10mg q." | 6.71 | Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003) |
| "Providing pain management for known opioid abusers is a challenging clinical task, in part because little is known about their pain experience and analgesic requirements." | 6.69 | Pain responses in methadone-maintained opioid abusers. ( Charuvastra, VC; Compton, P; Kintaudi, K; Ling, W, 2000) |
| " We found that gastrointestinal side effects were mainly reported with prolonged use, significant bleeding was reported in adenotonsillectomy, and adverse renal effects appeared to be limited to patients with specific coexisting risk factors." | 6.58 | Narrative review shows that the short-term use of ketorolac is safe and effective in the management of moderate-to-severe pain in children. ( Amoroso, S; Barbi, E; Calligaris, L; Marzuillo, P, 2018) |
| "Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) with strong analgesic activity." | 6.40 | Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. ( Brogden, RN; Gillis, JC, 1997) |
| "The aim of this prospective, double-blind, randomized controlled trial was to compare the effect of oral premedication of meloxicam, ketorolac, dexamethasone, ibuprofen, or placebo on the success of inferior alveolar nerve blocks (IANB) of mandibular posterior teeth in patients experiencing symptomatic irreversible pulpitis." | 5.69 | Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial. ( Elnaghy, AM; Elsaka, SE; Elshazli, AH, 2023) |
| "This randomized double-blinded trial aimed to compare the anesthetic success of inferior alveolar nerve blocks (IANBs) with 2% lidocaine in mandibular molars with symptomatic irreversible pulpitis (SIP) after oral premedication of prednisolone, dexamethasone, and ketorolac with placebo." | 5.69 | Effect of Preoperative Oral Steroids in Comparison to Anti-inflammatory on Anesthetic Success of Inferior Alveolar Nerve Block in Mandibular Molars with Symptomatic Irreversible Pulpitis-A Double-blinded Randomized Clinical Trial. ( Hegde, V; Kulkarni, V; Nagendrababu, V; Setzer, FC; Shaikh, S; Shanmugasundaram, S; Suresh, N, 2023) |
| "Intravenous ketorolac is commonly used for treating migraine headaches in children." | 5.51 | Intranasal ketorolac versus intravenous ketorolac for treatment of migraine headaches in children: A randomized clinical trial. ( Babineau, SE; Carter, RC; Chernick, LS; Dayan, PS; DePeter, KC; Fan, W; Friedman, BW; Gonzalez, AE; Kwok, MY; Lubell, TR; McLaren, SH; Roskind, CG; Tsze, DS, 2022) |
| "To compare pain and the need for the opioid fentanyl use associated with the administration of phenylephrine 1." | 5.51 | Pain control and reduction of opioid use associated with intracameral phenylephrine1.0%-ketorolac 0.3% administered during cataract surgery. ( Donnenfeld, ED; Mychajlyszyn, A; Mychajlyszyn, D; Stein, R, 2022) |
| " The purpose of this study was to evaluate the effects of adding dexamethasone to ketorolac on pain control in acute renal colic." | 5.51 | Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial. ( Farrokhi, E; Haghighi, R; Hosseini, SS; Lotfabadi, P; Rameshrad, M; Razi, A; Saadati, H, 2022) |
| "Our study found that ketorolac injections resulted in inferior pain reduction, functional score and grip improvement than triamcinolone injection in patients with radial styloid tenosynovitis." | 5.51 | Comparison of the effect of ketorolac versus triamcinolone acetonide injections for the treatment of de Quervain's tenosynovitis: a double-blind randomized controlled trial. ( Chuaychoosakoon, C; Fongsri, W; Suwannaphisit, S; Suwanno, P, 2022) |
| " Indomethacin was superior to celecoxib for pain score at rest at 8-12 h and celecoxib + parecoxib, diclofenac, and ketorolac for pain score on movement at 48 h." | 5.41 | Comparison of different nonsteroidal anti-inflammatory drugs for cesarean section: a systematic review and network meta-analysis. ( Blake, L; Carvalho, B; Carver, AL; Desai, N; Murdoch, I; O'Carroll, JE; Onwochei, DN; Sultan, P, 2023) |
| " Our review shows that: - There may be little or no difference in pain relief (single dose IN vs IV fentanyl MD 4 mm, 95% CI -8 to 16 at 30 min by 100 mm VAS; multiple doses IN vs IV fentanyl MD 0, 95%CI -0." | 5.41 | Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis. ( Austad, B; Iakovleva, E; Munblit, D; Pedersen, SA; Prescott, MG; Simpson, MR; Vallersnes, OM, 2023) |
| "Life-threatening acute respiratory distress syndrome (ARDS) complicates the recovery of patients with burn and inhalation injury." | 5.32 | Ketorolac may control more than pain. ( Isik, F, 2003) |
| "In this double-blind clinical trial study, the patients with renal colic pain were randomly divided into 2 groups; Group I received an intravenous infusion of 30 mg of Ketorolac and normal saline as placebo, Group II 50 mg/kg magnesium sulphate 50%/100 ml normal plus 30 mg of Ketorolac." | 5.30 | Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study. ( Aryan, A; Fahimi, MA; Maleki Verki, M; Motamed, H; Porozan, S, 2019) |
| "To compare the safety and efficacy of xylocaine gel and ketorolac as opioid-sparing analgesia compared with pethidine for shock wave lithotripsy (SWL) pain." | 5.30 | Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial. ( Abol-Enein, H; Atwa, AM; El-Assmy, A; Elbaset, MA; Fadallah, M; Ghobrial, FK; Hashem, A; Laymon, M; Sheir, KZ, 2019) |
| "This review was designated to evaluate the efficacy of parenteral ketorolac in treating acute migraine headache." | 5.22 | Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis. ( Abu Bakar, MA; Baharuddin, KA; Norhayati, MN; Nurathirah, MN; Yazid, MB, 2022) |
| "To evaluate intramuscular ketorolac compared with placebo saline injection for pain control with intrauterine device (IUD) placement." | 5.20 | Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial. ( Mody, SK; Ngo, LL; Ward, KK, 2015) |
| "Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain." | 5.19 | Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014) |
| "Lidocaine-prilocaine cream was most effective on probe-related pain, whereas lidocaine-ketorolac gel was most effective on sampling-related pain." | 5.17 | Noninfiltrative anesthesia for transrectal prostate biopsy: a randomized prospective study comparing lidocaine-prilocaine cream and lidocaine-ketorolac gel. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2013) |
| "What's known on the subject? and What does the study add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal prostate biopsy, but not pain due to periprostatic infiltration." | 5.16 | Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2012) |
| "To determine the efficacy of preoperative intravenous ketorolac in reducing intraoperative and postoperative pain and improving patient satisfaction in patients undergoing single-stage adjustable strabismus surgery." | 5.15 | The efficacy of intravenous ketorolac for pain relief in single-stage adjustable strabismus surgery: a prospective, randomized, placebo-controlled trial. ( Bae, SJ; Chang, JH; Chung, SA; Kim, WK; Lee, JB; Rhiu, S, 2011) |
| " The aim was to explore the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg administered intravenously on experimental pain models in human beings." | 5.15 | A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination. ( Besson, M; Daali, Y; Dayer, P; Desmeules, J; Ing Lorenzini, K; Salomon, D, 2011) |
| "To study the effects of a paracervical block with combined ketorolac and lidocaine on perceived pain during first-trimester surgical abortion." | 5.14 | Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial. ( Burke, A; Cansino, C; Edelman, A; Jamshidi, R, 2009) |
| "Acetaminophen plus codeine is effective in pain control in polytrauma patients at least in our series." | 5.14 | Acetaminophen plus codeine compared to ketorolac in polytrauma patients. ( Buccelletti, F; Calcinaro, S; Carroccia, A; De Marco, G; Franceschi, F; Gentiloni Silveri, N; Giannuzzi, R; Gilardi, E; Giupponi, B; Mancini, F; Marini, M; Marsiliani, D; Merra, G; Potenza, A, 2010) |
| "Topical ketorolac tromethamine usage is no more effective than artificial tears for pain relief during posterior segment laser procedures in proliferative diabetic retinopathy patients." | 5.12 | Topical ketorolac 0.5% for ocular pain relief during scatter laser photocoagulation with 532 nm green laser. ( Esgin, H; Samut, HS, 2006) |
| "We compare the effectiveness of intravenous ketorolac and intravenous prochlorperazine in the treatment of pediatric migraine headaches." | 5.11 | Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac. ( Anderson, AC; Brousseau, DC; Duffy, SJ; Linakis, JG, 2004) |
| "No subjects treated with parecoxib sodium or placebo developed gastroduodenal ulcers or > or =11 erosions/ulcers." | 5.11 | Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects. ( Harris, SI; Hubbard, RC; LeComte, D; Stoltz, RR, 2004) |
| "If used correctly, either an opioid (morphine) or a nonsteroidal anti-inflammatory (ketorolac) can substantially reduce pain during chest tube removal without causing adverse sedative effects." | 5.11 | Appropriately timed analgesics control pain due to chest tube removal. ( Ley, SJ; Puntillo, K, 2004) |
| " 15 and 30 mg ketorolac reduces pain following propofol injection." | 5.10 | Effect of pretreatment with ketorolac on propofol injection pain. ( Buerkle, H; Chou, AK; Huang, YW; Lee, TH; Lin, CR; Lin, SH; Lu, CY; Muhammad, R; Yang, LC, 2002) |
| "Patients receiving ketorolac and those receiving placebo were of similar age, weight, gender, number of prior ED visits, number of prior hospital admissions, duration of pain prior to presentation, and initial pain score." | 5.09 | Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis. ( Givens, TG; Hardwick, WE; King, WD; Lawley, D; Monroe, KW, 1999) |
| "We performed a randomised, double-blind, prospective trial to discover whether intravenous ketorolac 10 mg made up to 2 ml with saline, with or without venous occlusion for 2 min, reduces the pain on injection of propofol." | 5.09 | Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol. ( Barkshire, KF; Dexter, T; Yull, DN, 2000) |
| "To investigate the cost effectiveness of intravenous ketorolac compared with intravenous morphine in relieving pain after blunt limb injury in an accident and emergency department." | 5.09 | Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. ( Cheung, NK; Cocks, RA; Jacobs, P; Lam, PK; Ng, YC; Rainer, TH; Tam, M; Wong, R, 2000) |
| "To evaluate the efficacy of IM ketorolac versus that of oral ibuprofen in acute musculoskeletal pain." | 5.08 | Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995) |
| "To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning." | 5.08 | Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995) |
| "Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion." | 5.08 | Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995) |
| "25% bupivacaine without epinephrine to those of normal saline on chest tube removal pain in cardiothoracic surgery patients." | 5.08 | Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial. ( Puntillo, KA, 1996) |
| "A randomised, double-blind, controlled trial was undertaken to compare three different methods of reducing pain during the intravenous injection of propofol." | 5.08 | The effect of pretreatment with ketorolac on pain during intravenous injection of propofol. ( Power, I; Smith, AJ, 1996) |
| "We studied the comparative effects of ketorolac versus bupivacaine supplementation of hydromorphone (HM) patient-controlled epidural analgesia (PCEA) on the HM requirement, postoperative pain, and pulmonary function in 62 consenting patients after thoracotomy procedures." | 5.08 | Effects of ketorolac versus bupivacaine coadministration during patient-controlled hydromorphone epidural analgesia after thoracotomy procedures. ( Bossard, RF; Singh, H; White, PF; Yeatts, RW, 1997) |
| "To determine if a single dose of intramuscular ketorolac given on presentation to the emergency department has a narcotic-sparing effect in adult patients with sickle cell vaso-occlusive crisis pain." | 5.07 | Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992) |
| "Ketorolac is a member of the pyrrolo-pyrrole group of NSAIDs, and has been available in several formulations for some time, for the treatment of pain." | 4.88 | Intranasal ketorolac: for short-term pain management. ( Garnock-Jones, KP, 2012) |
| "Topical NSAIDs were found to be more effective in controlling CME, pain, iritis, and photophobia after cataract surgery compared with the intracanalicular dexamethasone insert in the presence of intracameral phenylephrine/ketorolac." | 4.31 | Comparison of postcataract surgery anti-inflammatory regimens on the incidence of cystoid macular edema, iritis, pain, and photophobia. ( Visco, DM, 2023) |
| "In May 2022, we conducted a search of major databases, MEDLINE (PubMed and Ovid), Embase, Epistemonikos, and the Cochrane Database of Systematic Reviews to identify eligible SRs on ketorolac for perioperative pain." | 4.12 | An analysis of harms reporting in systematic reviews regarding ketorolac for management of perioperative pain. ( Flores, H; Garrett, M; Kee, M; Magee, T; Modi, J; Roberts, W; Rucker, B; Vassar, M; Wise, A, 2022) |
| "To assess the effectiveness of intracameral phenylephrine-ketorolac during cataract surgery compared with postoperative topical steroids in reducing the incidence of postoperative clinical cystoid macular edema (CME) confirmed via optical coherence tomography (OCT), breakthrough iritis, pain, and photophobia." | 3.96 | Effect of intracameral phenylephrine 1.0%-ketorolac 0.3% on postoperative cystoid macular edema, iritis, pain, and photophobia after cataract surgery. ( Bedi, R; Visco, DM, 2020) |
| "Ketorolac is a reasonable non-narcotic alternative to fentanyl which provides equal pain control and does not increase tube occlusion rates." | 3.96 | Perioperative pain control and tympanostomy tube outcomes. ( Adil, E; Irace, AL; Kawai, K; Leung, P; Riley, B, 2020) |
| "The current study aimed to investigate the effectiveness of a developed sodium alginate and polyvinylpyrrolidone K-25 (PVP K-25) polymeric wafer for the co-delivery of ketorolac and lidocaine to soft tissues for healing and pain control following gingivectomy." | 3.88 | Mucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application. ( El-Feky, GS; Farouk Abdulmaguid, R; Kamel, R; Zayed, GM, 2018) |
| "The objective of the study was to investigate the iontophoretic delivery kinetics of ketorolac (KT), a highly potent NSAID and peripherally-acting analgesic that is currently indicated to treat moderate to severe acute pain." | 3.80 | Iontophoretic transport kinetics of ketorolac in vitro and in vivo: demonstrating local enhanced topical drug delivery to muscle. ( de Souza, JG; Gelfuso, GM; Gratieri, T; Kalia, YN; Lopez, RF; Pujol-Bello, E, 2014) |
| " Both pretreatment and post-treatment with the opioid antagonist naloxone into the DH significantly reduced the antinociceptive effect of NSAIDs in both pain models." | 3.80 | Antinociceptive tolerance to NSAIDs microinjected into dorsal hippocampus. ( Gurtskaia, G; Nebieridze, M; Nozadze, I; Tsagareli, MG; Tsiklauri, N, 2014) |
| "Considering the potential pain and dissatisfaction of rigid cystoscopic ureteral stent removal, procedures utilizing moderate sedation with midazolam or general anesthesia using propofol without muscle relaxation should be considered." | 3.80 | Pain and satisfaction during rigid cystoscopic ureteral stent removal: a preliminary study. ( Cho, SW; Choi, H; Kim, JH; Kim, MG; Park, SY; Song, D; Song, YS, 2014) |
| " All patients received ketorolac and acetaminophen with codeine for pain, and early in the series 7 patients received morphine." | 3.75 | Contemporary open ureteral reimplantation without morphine: assessment of pain and outcomes. ( Chamie, K; Chi, A; Hu, B; Keegan, KA; Kurzrock, EA, 2009) |
| "This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain." | 3.73 | Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005) |
| "Systemic lidocaine and other local anesthetics reduce hypersensitivity states induced by both acute inflammation and peripheral nerve injury in animals and produce analgesia in some patients with chronic pain." | 3.72 | Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac. ( Du, W; Eisenach, JC; Ma, W, 2003) |
| "We previously reported the up-regulation of cyclooxygenase 2 (COX2) in injured sciatic nerve of rats with partial sciatic nerve ligation (PSNL) and the reversal of PSNL-elicited tactile allodynia by local injection of the COX inhibitor ketorolac [Eur J Neurosci 15 (2002) 1037]." | 3.72 | Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury. ( Eisenach, JC; Ma, W, 2003) |
| ") had no effect in two acute pain models, namely, the acetic acid-induced writhing (visceral pain) and the formalin test (tonic pain)." | 3.72 | Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. ( Jain, NK; Kulkarni, SK; Padi, SS; Singh, S, 2004) |
| " The parameters considered as prognostic factors were pain relief with ketorolac (K) or ketorolac plus opiate treatment (KO), and stone size (>or= or <6 mm)." | 3.71 | Comparison of stone size and response to analgesic treatment in predicting outcome of patients with renal colic. ( Prina, LD; Rancatore, E; Secic, M; Weber, RE, 2002) |
| "We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain." | 3.70 | Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998) |
| "Caffeine potentiation of ketorolac-induced antinociception in the pain-induced functional impairment model in rats was assessed." | 3.70 | Effect of coadministration of caffeine and either adenosine agonists or cyclic nucleotides on ketorolac analgesia. ( Aguirre-Bañuelos, P; Castañeda-Hernández, G; Granados-Soto, V; López-Muñoz, FJ, 1999) |
| "To compare the clinical efficacy of single doses of intramuscular ketorolac and oral ibuprofen in the emergency department (ED) treatment of acute pain." | 3.69 | NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac. ( Price, SD; Watson, WA; Wright, JM, 1994) |
| "To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain." | 3.68 | Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993) |
| "Ketorolac tromethamine was not superior to FM or PB in reducing lameness using a HBS model." | 2.94 | Ketorolac Is Not More Effective Than Flunixin Meglumine or Phenylbutazone in Reducing Foot Pain in Horses. ( Brunner, TJ; Cooper, BR; Davern, AJ; Grady, SE; Lescun, TB; Moore, GE; Taylor, SD, 2020) |
| " Adverse drug reactions may be renal, gastrointestinal, hematological, or immunologic." | 2.82 | Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years. ( Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC, 2022) |
| "Ketorolac or vehicle was instilled before the injection, and pain perception was recorded on a 0 to 100 Visual Analog Scale (VAS) immediately after the intravitreal administration." | 2.77 | Effect of ketorolac 0.5% drops on patients' pain perception during intravitreal injection procedure. ( Beredima, E; Georgakopoulos, CD; Makri, OE; Pharmakakis, NM; Vasilakis, PT, 2012) |
| "Pretreatment with parecoxib or ketorolac reduced the postinfusion area of pinprick hyperalgesia (P < 0." | 2.76 | Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans. ( Draegni, T; Heyerdahl, F; Lenz, H; Raeder, J; Schmelz, M; Stubhaug, A, 2011) |
| "Cutaneous allodynia and dysesthesia were then mapped and thermal and mechanical thresholds were measured." | 2.72 | The effect of intravenous ketorolac on capsaicin-induced deep tissue hyperalgesia. ( Kumar, K; Polston, GR; Wallace, MS, 2006) |
| "ketorolac (10mg q." | 2.71 | Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003) |
| "Ketorolac tromethamine is a well-tolerated, effective medication in the treatment of acute biliary colic." | 2.70 | Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic. ( Henderson, SO; Newton, E; Swadron, S, 2002) |
| "Providing pain management for known opioid abusers is a challenging clinical task, in part because little is known about their pain experience and analgesic requirements." | 2.69 | Pain responses in methadone-maintained opioid abusers. ( Charuvastra, VC; Compton, P; Kintaudi, K; Ling, W, 2000) |
| "Ketorolac appears to be a safe and effective therapy for children when given in appropriate doses for a limited duration." | 2.67 | Clinical experience with ketorolac in children. ( Buck, ML, 1994) |
| " We found that gastrointestinal side effects were mainly reported with prolonged use, significant bleeding was reported in adenotonsillectomy, and adverse renal effects appeared to be limited to patients with specific coexisting risk factors." | 2.58 | Narrative review shows that the short-term use of ketorolac is safe and effective in the management of moderate-to-severe pain in children. ( Amoroso, S; Barbi, E; Calligaris, L; Marzuillo, P, 2018) |
| "Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) with strong analgesic activity." | 2.40 | Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. ( Brogden, RN; Gillis, JC, 1997) |
| "Ketorolac was not associated with increased risk of postoperative bleeding (0." | 1.72 | Predictors and Trends of Opioid-Sparing Radical Prostatectomy From a Large National Cohort. ( Bowman, A; Brant, A; Johnson, JP; Lewicki, P; Shoag, JE; Sze, C; Weinstein, IC, 2022) |
| "Ketorolac was associated with significantly longer closure times vs untreated control at both the 2." | 1.56 | Platelet Function: Meloxicam Intravenous in Whole Blood Samples From Healthy Volunteers. ( Du, W; Freyer, A; Hobson, S; Jahr, JS; Mack, R; McCallum, S; Minger, K; Searle, S, 2020) |
| " Both alone and in combination with ketorolac; S." | 1.46 | Synergistic antinociceptive interaction of Syzygium aromaticum or Rosmarinus officinalis coadministered with ketorolac in rats. ( Aguilar-Mariscal, H; Beltrán-Villalobos, KL; Déciga-Campos, M; González-Trujano, ME; López-Muñoz, FJ; Martínez-Salazar, MF; Ramírez-Cisneros, MLÁ; Rios, MY, 2017) |
| "When ibuprofen alone was administered, pain scores equal to or lower than 5/10 were associated with the greatest sensitivity and specificity for discharge." | 1.46 | Factors Associated With Discharge After Initial Emergency Treatment of Pediatric Migraine. ( Aravamuthan, BR; Mar, SS; Williams, KG, 2017) |
| " After F3 administration to rats, the Cmax (2." | 1.42 | Pharmacokinetics and analgesic effect of ketorolac floating delivery system. ( Abou El Ela, Ael S; El-Maraghy, DA; Hassan, MA; Radwan, MA, 2015) |
| "Population pharmacodynamic experiments sometime involve repeated measurements of ordinal random variables at specific time points." | 1.36 | Sample size/power calculations for repeated ordinal measurements in population pharmacodynamic experiments. ( Aarons, L; Ogungbenro, K, 2010) |
| " In a single dose study, its pharmacokinetic profile was compared with that of ketorolac." | 1.35 | Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations. ( Abignente, E; Boatto, G; Calignano, A; Curcio, A; Gavini, E; La Rana, G; Melisi, D; Nieddu, M; Rimoli, MG; Russo, R; Sasso, O, 2009) |
| " The MQS score accounted for variations in the types of analgesic medications, routes of administration, dosing schedules, and opioid dosing requirements." | 1.34 | Quantification of analgesic use in children with sickle cell disease. ( Beyer, JE; Jacob, E; Miaskowski, C; Savedra, M; Styles, L; Treadwell, M, 2007) |
| "Naloxone pretreatment had no effect on the antinociceptive effects of intradermal diclofenac, ketorolac, lysine acetyl salicylate, and sodium salicylate." | 1.34 | The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test. ( Deveci, MS; Dogrul, A; Gul, H; Gülmez, SE; Ossipov, MH; Porreca, F; Tulunay, FC, 2007) |
| "Pain is the most prominent feature of IC and current therapies provide limited relief." | 1.34 | Pharmacological validation of a model of cystitis pain in the mouse. ( Leventhal, L; Piesla, M; Wantuch, C, 2007) |
| "Ketorolac is a non-steroidal anti-inflammatory drug." | 1.34 | Ketorolac-dextran conjugates: synthesis, in vitro and in vivo evaluation. ( Chaturvedi, SC; Trivedi, P; Vyas, S, 2007) |
| "Bone cancer pain is mostly associated with an inflammatory response dominated by local activation of osteoclasts and by astrogliosis in the spinal cord." | 1.33 | The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception. ( Beitz, A; Eikmeier, L; Fike, JR; Jasmin, L; Ohara, PT; Tien, DA; Vit, JP; Wilcox, GL, 2006) |
| ", its pharmacokinetic (PK) properties] and how these PK properties differ between individuals in a population (i." | 1.32 | An evaluation of population D-optimal designs via pharmacokinetic simulations. ( Dodds, MG; Foracchia, M; Hooker, AC; Vicini, P, 2003) |
| "Life-threatening acute respiratory distress syndrome (ARDS) complicates the recovery of patients with burn and inhalation injury." | 1.32 | Ketorolac may control more than pain. ( Isik, F, 2003) |
| " Rats were anesthetized, then the electromyographic response in the rectus abdominus muscle and mean arterial blood pressure change to UCD was recorded before and with cumulative dosing of intravenous or intrathecal ketorolac." | 1.32 | Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats. ( Eisenach, JC; Sandner-Kiesling, A; Shin, SW, 2003) |
| "Ketorolac is a powerful potentiator of morphine antinociception during visceral nociception in the rat." | 1.29 | Ketorolac potentiates morphine antinociception during visceral nociception in the rat. ( Gebhart, GF; Maves, TJ; Meller, ST; Pechman, PS, 1994) |
| "The gene for sickle cell disease is carried by 8% of the African-American population in the United States." | 1.28 | Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.26) | 18.7374 |
| 1990's | 47 (29.56) | 18.2507 |
| 2000's | 46 (28.93) | 29.6817 |
| 2010's | 43 (27.04) | 24.3611 |
| 2020's | 21 (13.21) | 2.80 |
| Authors | Studies |
|---|---|
| Muchowski, JM | 1 |
| Unger, SH | 1 |
| Ackrell, J | 1 |
| Cheung, P | 1 |
| Cooper, GF | 1 |
| Cook, J | 2 |
| Gallegra, P | 1 |
| Halpern, O | 1 |
| Koehler, R | 1 |
| Kluge, AF | 1 |
| Curcio, A | 1 |
| Sasso, O | 1 |
| Melisi, D | 1 |
| Nieddu, M | 1 |
| La Rana, G | 1 |
| Russo, R | 1 |
| Gavini, E | 1 |
| Boatto, G | 1 |
| Abignente, E | 1 |
| Calignano, A | 1 |
| Rimoli, MG | 1 |
| Chae, E | 1 |
| Yi, H | 1 |
| Choi, Y | 1 |
| Cho, H | 1 |
| Lee, K | 1 |
| Moon, H | 1 |
| Tsze, DS | 1 |
| Lubell, TR | 1 |
| Carter, RC | 1 |
| Chernick, LS | 1 |
| DePeter, KC | 1 |
| McLaren, SH | 1 |
| Kwok, MY | 1 |
| Roskind, CG | 1 |
| Gonzalez, AE | 1 |
| Fan, W | 1 |
| Babineau, SE | 1 |
| Friedman, BW | 1 |
| Dayan, PS | 1 |
| Donnenfeld, ED | 1 |
| Mychajlyszyn, D | 1 |
| Mychajlyszyn, A | 1 |
| Stein, R | 1 |
| Martínez-Martínez, MDC | 1 |
| Parra-Flores, LI | 1 |
| Baeza-Flores, GDC | 1 |
| Torres-López, JE | 2 |
| Nurathirah, MN | 1 |
| Yazid, MB | 1 |
| Norhayati, MN | 1 |
| Baharuddin, KA | 1 |
| Abu Bakar, MA | 1 |
| Razi, A | 1 |
| Farrokhi, E | 1 |
| Lotfabadi, P | 1 |
| Hosseini, SS | 1 |
| Saadati, H | 1 |
| Haghighi, R | 1 |
| Rameshrad, M | 1 |
| Visco, DM | 2 |
| Brant, A | 1 |
| Lewicki, P | 1 |
| Johnson, JP | 1 |
| Weinstein, IC | 1 |
| Bowman, A | 1 |
| Sze, C | 1 |
| Shoag, JE | 1 |
| Suwannaphisit, S | 1 |
| Suwanno, P | 1 |
| Fongsri, W | 1 |
| Chuaychoosakoon, C | 1 |
| Ziesenitz, VC | 1 |
| Welzel, T | 1 |
| van Dyk, M | 1 |
| Saur, P | 1 |
| Gorenflo, M | 1 |
| van den Anker, JN | 1 |
| Modi, J | 1 |
| Magee, T | 1 |
| Rucker, B | 1 |
| Flores, H | 1 |
| Wise, A | 1 |
| Kee, M | 1 |
| Garrett, M | 1 |
| Roberts, W | 1 |
| Vassar, M | 1 |
| Elnaghy, AM | 3 |
| Elshazli, AH | 3 |
| Elsaka, SE | 3 |
| Hegde, V | 1 |
| Shanmugasundaram, S | 1 |
| Shaikh, S | 1 |
| Kulkarni, V | 1 |
| Suresh, N | 1 |
| Setzer, FC | 1 |
| Nagendrababu, V | 1 |
| Murdoch, I | 1 |
| Carver, AL | 1 |
| Sultan, P | 1 |
| O'Carroll, JE | 1 |
| Blake, L | 1 |
| Carvalho, B | 1 |
| Onwochei, DN | 1 |
| Desai, N | 1 |
| Schubert, AK | 1 |
| Seneviratne, V | 1 |
| Stolz, J | 1 |
| Wiesmann, T | 1 |
| Wulf, H | 1 |
| Eberhart, L | 1 |
| Dinges, HC | 1 |
| Prescott, MG | 1 |
| Iakovleva, E | 1 |
| Simpson, MR | 1 |
| Pedersen, SA | 1 |
| Munblit, D | 1 |
| Vallersnes, OM | 1 |
| Austad, B | 1 |
| Miranda, HF | 1 |
| Noriega, V | 1 |
| Sierralta, F | 1 |
| Poblete, P | 1 |
| Aranda, N | 1 |
| Prieto, JC | 1 |
| Jahr, JS | 1 |
| Searle, S | 1 |
| McCallum, S | 1 |
| Mack, R | 1 |
| Minger, K | 1 |
| Freyer, A | 1 |
| Du, W | 2 |
| Hobson, S | 1 |
| Galvis, V | 1 |
| Tello, A | 1 |
| Alfonso, MA | 1 |
| Carreño, NI | 1 |
| Berrospi, RD | 1 |
| Niño, CA | 1 |
| Bedi, R | 1 |
| Grady, SE | 1 |
| Lescun, TB | 1 |
| Moore, GE | 1 |
| Cooper, BR | 1 |
| Davern, AJ | 1 |
| Brunner, TJ | 1 |
| Taylor, SD | 1 |
| Riley, B | 1 |
| Kawai, K | 1 |
| Irace, AL | 1 |
| Leung, P | 1 |
| Adil, E | 1 |
| Torre, G | 1 |
| Avvedimento, S | 1 |
| Guastafierro, A | 1 |
| Faenza, M | 1 |
| Pieretti, G | 1 |
| Cuomo, R | 1 |
| Izzo, S | 1 |
| Ciccarelli, F | 1 |
| Vadivelu, N | 1 |
| Chang, D | 1 |
| Helander, EM | 1 |
| Bordelon, GJ | 1 |
| Kai, A | 1 |
| Kaye, AD | 1 |
| Hsu, D | 1 |
| Bang, D | 1 |
| Julka, I | 1 |
| Beltrán-Villalobos, KL | 1 |
| Déciga-Campos, M | 1 |
| Aguilar-Mariscal, H | 1 |
| González-Trujano, ME | 2 |
| Martínez-Salazar, MF | 1 |
| Ramírez-Cisneros, MLÁ | 1 |
| Rios, MY | 1 |
| López-Muñoz, FJ | 5 |
| Kao, CW | 1 |
| Lee, D | 1 |
| Wu, MH | 1 |
| Chen, JK | 1 |
| He, HL | 1 |
| Liu, SJ | 1 |
| El-Feky, GS | 1 |
| Farouk Abdulmaguid, R | 1 |
| Zayed, GM | 1 |
| Kamel, R | 1 |
| Marzuillo, P | 1 |
| Calligaris, L | 1 |
| Amoroso, S | 1 |
| Barbi, E | 1 |
| Tsiklauri, N | 3 |
| Pirkulashvili, N | 1 |
| Nozadze, I | 3 |
| Nebieridze, M | 2 |
| Gurtskaia, G | 3 |
| Abzianidze, E | 2 |
| Tsagareli, MG | 3 |
| Leow, MQH | 1 |
| Hay, ASR | 1 |
| Ng, SL | 1 |
| Choudhury, MM | 1 |
| Li, H | 1 |
| McGrouther, DA | 1 |
| Tay, SC | 1 |
| Wu, PC | 1 |
| Shieh, DB | 1 |
| Hsiao, HT | 2 |
| Wang, JC | 1 |
| Lin, YC | 1 |
| Liu, YC | 1 |
| Matava, MJ | 1 |
| Maleki Verki, M | 1 |
| Porozan, S | 1 |
| Motamed, H | 1 |
| Fahimi, MA | 1 |
| Aryan, A | 1 |
| Moerke, MJ | 1 |
| Li, G | 1 |
| Golani, LK | 1 |
| Negus, SS | 3 |
| Hashem, A | 1 |
| Ghobrial, FK | 1 |
| Elbaset, MA | 1 |
| Atwa, AM | 1 |
| Fadallah, M | 1 |
| Laymon, M | 1 |
| El-Assmy, A | 1 |
| Sheir, KZ | 1 |
| Abol-Enein, H | 1 |
| Van Hulle Vincent, C | 2 |
| Wilkie, DJ | 2 |
| Wang, E | 2 |
| Hirsch, S | 1 |
| Corradini, L | 1 |
| Just, S | 1 |
| Arndt, K | 1 |
| Doods, H | 1 |
| Gratieri, T | 1 |
| Pujol-Bello, E | 1 |
| Gelfuso, GM | 1 |
| de Souza, JG | 1 |
| Lopez, RF | 1 |
| Kalia, YN | 1 |
| Radwan, MA | 1 |
| Abou El Ela, Ael S | 1 |
| Hassan, MA | 1 |
| El-Maraghy, DA | 1 |
| Walker, NA | 1 |
| Bultitude, MF | 1 |
| Brislane, K | 1 |
| Thomas, K | 1 |
| Glass, JM | 1 |
| Buccelletti, F | 2 |
| Marsiliani, D | 2 |
| Zuccalà, G | 1 |
| Iacomini, P | 1 |
| Proietti, L | 1 |
| Pola, E | 1 |
| Zirio, G | 1 |
| Genitiempo, M | 1 |
| Marrocco, R | 1 |
| Conti, C | 1 |
| Brunetti, C | 1 |
| Rocchi, L | 1 |
| Merendi, G | 1 |
| D'Aurizio, G | 1 |
| Gilardi, E | 2 |
| Franceschi, F | 2 |
| Kim, JH | 1 |
| Park, SY | 1 |
| Kim, MG | 1 |
| Choi, H | 1 |
| Song, D | 1 |
| Cho, SW | 1 |
| Song, YS | 1 |
| Ngo, LL | 1 |
| Ward, KK | 1 |
| Mody, SK | 1 |
| Aravamuthan, BR | 1 |
| Mar, SS | 1 |
| Williams, KG | 1 |
| Chamie, K | 1 |
| Chi, A | 1 |
| Hu, B | 1 |
| Keegan, KA | 1 |
| Kurzrock, EA | 1 |
| Chaou, CH | 1 |
| Chen, CK | 1 |
| Chen, JC | 1 |
| Chiu, TF | 1 |
| Lin, CC | 1 |
| Cansino, C | 1 |
| Edelman, A | 1 |
| Burke, A | 1 |
| Jamshidi, R | 1 |
| Ogungbenro, K | 1 |
| Aarons, L | 1 |
| Chung, SY | 1 |
| Krambeck, AE | 1 |
| Walsh, RS | 1 |
| Denstedt, JD | 1 |
| Preminger, GM | 1 |
| Li, J | 1 |
| Evans, JC | 1 |
| Lingeman, JE | 1 |
| Eisenach, JC | 4 |
| Curry, R | 1 |
| Tong, C | 1 |
| Houle, TT | 1 |
| Yaksh, TL | 1 |
| Carroccia, A | 1 |
| Giupponi, B | 1 |
| De Marco, G | 1 |
| Merra, G | 1 |
| Mancini, F | 1 |
| Potenza, A | 1 |
| Giannuzzi, R | 1 |
| Calcinaro, S | 1 |
| Marini, M | 1 |
| Gentiloni Silveri, N | 1 |
| Hamza, M | 1 |
| Wang, XM | 1 |
| Wu, T | 1 |
| Brahim, JS | 1 |
| Rowan, JS | 1 |
| Dionne, RA | 1 |
| Joshi, HB | 1 |
| Keeley, FX | 1 |
| Timoney, AG | 1 |
| Rhiu, S | 1 |
| Chung, SA | 1 |
| Kim, WK | 1 |
| Chang, JH | 1 |
| Bae, SJ | 1 |
| Lee, JB | 1 |
| Martínez, AL | 1 |
| Chávez, M | 1 |
| Pellicer, F | 1 |
| Moreno, J | 1 |
| Lenz, H | 1 |
| Raeder, J | 1 |
| Draegni, T | 1 |
| Heyerdahl, F | 1 |
| Schmelz, M | 1 |
| Stubhaug, A | 1 |
| Cormio, L | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Nasal Migraine Cocktail Used In Pediatric Emergency Department: A Clinical Trial[NCT06083571] | Phase 2 | 120 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| Evaluation of Perioperative Usage of Ketorolac on Postoperative Pain Reduction in Pediatric Patients With Adenotonsillectom[NCT05074056] | Phase 4 | 200 participants (Anticipated) | Interventional | 2022-02-08 | Recruiting | ||
| Effectiveness of the Distraction Methods on Pain, Anxiety and Satisfaction During Cystoscopy[NCT02764294] | 120 participants (Actual) | Interventional | 2016-03-31 | Completed | |||
| Intravenous Ketorolac Administration to Attenuate Post-procedural Pain Associated With Intrauterine Device Placement: A Randomized, Double-Blind, Placebo-Controlled Trial[NCT05875571] | Phase 4 | 18 participants (Anticipated) | Interventional | 2023-09-30 | Not yet recruiting | ||
| Pain Control for Intrauterine Device Placement: A Randomized, Double Blind Control Trial of Ketorolac Prior to Intrauterine Device Placement.[NCT01664559] | 67 participants (Actual) | Interventional | 2012-07-31 | Completed | |||
| Multi-dose Ibuprofen Prophylaxis for IUD-insertion (MIPI): A Triple Blinded[NCT03868137] | 86 participants (Anticipated) | Interventional | 2020-09-28 | Recruiting | |||
| Does LI4 Acupuncture Provide an Effective Analgesia During Intrauterine Device[NCT04963582] | 72 participants (Actual) | Interventional | 2021-07-05 | Completed | |||
| Oxybutynin for Post-surgical Bladder Pain and Urgency[NCT03952299] | Phase 3 | 100 participants (Anticipated) | Interventional | 2021-09-01 | Recruiting | ||
| Paracervical Block for Pain Control During Osmotic Dilator Placement: a Randomized Controlled Trial[NCT02354092] | 14 participants (Actual) | Interventional | 2015-04-02 | Terminated | |||
| Paracervical Block With Ketorolac and Lidocaine in First Trimester Surgical Abortions[NCT00617097] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| A Prospective, Randomized, Pilot Study of Preoperative Anti-Inflammatory Therapy for Ureteral Stent Symptoms[NCT03638999] | Early Phase 1 | 36 participants (Anticipated) | Interventional | 2018-07-31 | Recruiting | ||
| Can Opioid-induced Hyperalgesia be Prevented by Gradual Dose Reduction vs. Abrupt Withdrawal of Remifentanil?[NCT01702389] | Phase 4 | 16 participants (Actual) | Interventional | 2012-10-31 | Completed | ||
| Prospective, Randomized, Allocation-Concealed, Blinded Study Designed to Compare Ketorolac Sublingual and Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children[NCT02653742] | Phase 4 | 150 participants (Anticipated) | Interventional | 2015-05-31 | Recruiting | ||
| The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510] | Phase 4 | 200 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Assessment of the Analgesic Efficacy of Intravenous Ibuprofen in Biliary Colic[NCT02268955] | 22 participants (Actual) | Interventional | 2014-09-09 | Completed | |||
| Placebo Effect in Children With Attention Deficit Disorder and/or Hyperactivity Disorder[NCT04766580] | 44 participants (Anticipated) | Interventional | 2021-02-17 | Recruiting | |||
| Intranasal Lidocaine to Treat Pediatric Migraine in the Emergency Department[NCT03576820] | Phase 3 | 50 participants (Anticipated) | Interventional | 2018-10-15 | Recruiting | ||
| A Randomized Double Blinded Study Comparing Use of Prochlorperazine Versus Prochlorperazine and Ketorolac in the Treatment of Pediatric Migraine in the Emergency Department[NCT01534806] | Phase 4 | 0 participants (Actual) | Interventional | 2012-01-31 | Withdrawn (stopped due to Drug is backordered;) | ||
| Effect of Intravenous Dynastat on Postoperative Sore Throat: A Randomized Double-blinded Controlled Trial[NCT03915561] | Phase 2 | 140 participants (Anticipated) | Interventional | 2019-03-01 | Recruiting | ||
| Acute Kidney Injury and Nonsteroidal Anti-inflammatory Drugs in Patients Undergoing High-risk Abdominal or Thoracic Surgery[NCT02553174] | 50 participants (Actual) | Observational | 2016-06-01 | Terminated (stopped due to unable to recruit sufficient patients to satisfy study protocols) | |||
| A Randomized Double-blinded Trial Comparing the Clinical Efficacy and Pharmacokinetic Parameters of Oral Diclofenac and Intramuscular Diclofenac in Patients With Acute Limb Injuries[NCT03472339] | Phase 4 | 300 participants (Anticipated) | Interventional | 2018-01-15 | Recruiting | ||
| Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia[NCT02024568] | Phase 2 | 38 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | ||
| Preliminary Studies for Whole Genome Association Study (WGAS) in Acute Perioperative Pain[NCT01557751] | 156 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| A Prospective Randomized Double-blind Placebo Controlled Trial; Does Pre and Postoperative Dextromethorphan Reduce Post-tonsillectomy Pain in Children?[NCT02727491] | Phase 4 | 85 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis[NCT02465138] | Phase 4 | 0 participants (Actual) | Interventional | 2023-11-30 | Withdrawn (stopped due to Lack of Funding) | ||
| Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans[NCT01222091] | Phase 2 | 10 participants (Actual) | Interventional | 2009-02-28 | Completed | ||
| The Effects of Opioid Taper on Opioid-Induced Hyperalgesia[NCT03063905] | 15 participants (Actual) | Observational | 2017-01-31 | Terminated (stopped due to funding expired) | |||
| Evaluation of the Effects of Ketorolac 15mg IV Versus 30mg IV on Duration of Analgesia in Patients Who Present to the Emergency Department With Renal Colic[NCT05776953] | Phase 4 | 200 participants (Anticipated) | Interventional | 2023-12-21 | Recruiting | ||
| A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887] | Phase 2 | 150 participants (Actual) | Interventional | 2004-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The patient marked their pain on a 0 to 10cm visual analogue scale, where 0 cm is no pain and 10 cm is the worst pain ever. (NCT01664559)
Timeframe: Pain with IUD placement, measured immediately after placement
| Intervention | units on a scale (Median) |
|---|---|
| Placebo With 1cc Normal Saline IM | 5.2 |
| Toradol, 30mg in 1cc IM | 3.6 |
"The patient marked their pain on a 0 to 10cm visual analogue scale, where 0 cm is no pain and 10 cm is the worst pain ever.~Prior to injection of study drug, anticipated pain~Pain from study drug injection, measured immediately after injection~Pain from speculum insertion, measured immediately after insertion~Pain with tenaculum placement, measured immediately after placement~Pain with uterine sounding, measured immediately after removal of the sound~Pain at 5 minutes after placement of the intrauterine device~Pain at 15 minutes after placement of the intrauterine device" (NCT01664559)
Timeframe: immediately after each step (see description)
| Intervention | cm (Median) | |||||||
|---|---|---|---|---|---|---|---|---|
| 1) Anticipated pain | 2) Pain with injection | 3) Speculum insertion | 4) Tenaculum placement | 5) Uterine sounding | 6) Pain with IUD placement | 7) 5 min after placement | 8) 15 min after placement | |
| Placebo With 1cc Normal Saline IM | 2.8 | 1.8 | 2.3 | 6.3 | 8.4 | 8.1 | 3.7 | 4.8 |
| Toradol, 30mg in 1cc IM | 3.6 | 1.2 | 1.5 | 4.3 | 6.0 | 5.4 | 2.7 | 1.8 |
"The patient marked their pain on a 0 to 10cm visual analogue scale, where 0 cm is no pain and 10 cm is the worst pain ever.~Prior to injection of study drug, anticipated pain~Pain from study drug injection, measured immediately after injection~Pain from speculum insertion, measured immediately after insertion~Pain with tenaculum placement, measured immediately after placement~Pain with uterine sounding, measured immediately after removal of the sound~Pain at 5 minutes after placement of the intrauterine device~Pain at 15 minutes after placement of the intrauterine device" (NCT01664559)
Timeframe: immediately after each step (see description)
| Intervention | cm (Median) | ||||||
|---|---|---|---|---|---|---|---|
| Anticipated pain | Pain with injection | Speculum insertion | Tenaculum placement | Uterine sounding | 5 min after procedure | 15 min after procedure | |
| Placebo With 1cc Normal Saline IM | 4.4 | 1.0 | 2.6 | 3.9 | 5.0 | 2.2 | 1.6 |
| Toradol, 30mg in 1cc IM | 3.5 | 0.6 | 1.5 | 2.5 | 4.3 | 0.3 | 0.1 |
"Questions assessed in multiple choice format:~Side effects~injection site pain~overall satisfaction with IUD insertion experience~would they still recommend IUD placement to a friend?~significant pain for which they desired acetaminophen prior to leaving the office?" (NCT01664559)
Timeframe: assessed at 15 minutes after IUD insertion
| Intervention | participants (Number) | ||||
|---|---|---|---|---|---|
| Reported side effects | Injection site pain - just as bad/worse than IUD | Satisfied or very satisfied with overall IUD proc | Recommend IUD to a friend | Desires additional pain medication | |
| Placebo With 1cc Normal Saline IM | 12 | 8 | 30 | 28 | 16 |
| Toradol, 30mg in 1cc IM | 8 | 6 | 31 | 30 | 6 |
"The provider will be asked to fill out a multiple choice format questionnaire:~what level training are you?~which IUD was inserted?~what was the purpose of IUD placement?~what was the position of the uterus?~did the IUD placement process require cervical dilation?~were you able to complete the IUD insertion?~was there bleeding from the cervix that required more than 5 min to control?~were there any major complications with the IUD insertion?~did the patient take tylenol prior to leaving the office?" (NCT01664559)
Timeframe: Immediately after IUD placement, on average within 1 hour
| Intervention | participants (Number) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Level of training - PGY1 | Level of training - PGY2 | Level of training - PGY3 | Level of training - PGY4 | Level of training - Attending | IUD type - levonogestrel | IUD type - copper | Purpose of IUD - contraception | Purpose of IUD - AUB | Position of uterus - anteverted | Position of uterus - retroverted | Position of uterus - midpositioned | Cervical dilation needed | Able to complete the IUD placement | Significant bleeding | Major complications | Took acetaminophen prior to leaving the office | |
| Placebo With 1cc Normal Saline IM | 2 | 2 | 3 | 5 | 1 | 22 | 12 | 33 | 1 | 19 | 6 | 9 | 2 | 34 | 0 | 0 | 17 |
| Toradol, 30mg in 1cc IM | 5 | 13 | 6 | 6 | 3 | 28 | 2 | 32 | 1 | 20 | 5 | 8 | 2 | 33 | 2 | 0 | 7 |
"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) recorded at time immediately after osmotic dilator placement. 0 mm=No Pain and 100 mm= worst possible pain. A higher score indicates a higher level of pain." (NCT02354092)
Timeframe: Within 5 minutes of PCB or sham procedure
| Intervention | units on a scale (Mean) |
|---|---|
| Sham Group | 46 |
| Paracervical Block Group | 32 |
"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) recorded 15 minutes after osmotic dilator placement. mm=No Pain and 100 mm= worst possible pain. A higher mean score indicates a higher level of pain experienced at this time point." (NCT02354092)
Timeframe: 15 minutes after dilator placement
| Intervention | units on a scale (Mean) |
|---|---|
| Sham Group | 42 |
| Paracervical Block Group | 35 |
"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) recorded at time immediately after last injection for paracervical block OR script for sham injection. 0 mm=No Pain and 100 mm= worst possible pain. A higher score indicates a higher level of pain." (NCT02354092)
Timeframe: Within 5 minutes after baseline
| Intervention | units on a scale (Mean) |
|---|---|
| Sham Group | 19 |
| Paracervical Block Group | 39 |
"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) of pain recorded at baseline prior to the paracervical block or sham block procedure. 0 mm=No Pain and 100 mm= worst possible pain. A higher score indicates a higher level of pain." (NCT02354092)
Timeframe: Baseline, just prior to PCB or sham procedure
| Intervention | units on a scale (Mean) |
|---|---|
| Sham Group | 4 |
| Paracervical Block Group | 19 |
fever, chills, vomiting, heavy bleeding/clots (collected without regard to the specific event) (NCT00617097)
Timeframe: end of study (upon discharge from facility after procedure)
| Intervention | participants (Number) |
|---|---|
| Paracervical Block With Lidocaine | 3 |
| Paracervical Block With Ketorolac and Lidocaine | 0 |
100-mm Visual Analogue Scale -- minimum: 0 mm (lower satisfaction), maximum: 100 mm (greater satisfaction) (NCT00617097)
Timeframe: end of study (prior to clinic discharge)
| Intervention | mm (Mean) |
|---|---|
| Paracervical Block With Lidocaine | 62.9 |
| Paracervical Block With Ketorolac and Lidocaine | 63.6 |
(NCT00617097)
Timeframe: end of study
| Intervention | participants (Number) | |
|---|---|---|
| minor | serious | |
| Paracervical Block With Ketorolac and Lidocaine | 1 | 2 |
| Paracervical Block With Lidocaine | 1 | 0 |
"100-mm Visual Analogue Scale (VAS) during specific time intervals of D&C procedure: minimum: 0 mm (less pain); maximum: 100 mm (more pain)~Time intervals include: basline expected level of pain during procedure, after speculum insertion, at paracervical block injection, after dilation, end of procedure, and 30 minutes after procedure." (NCT00617097)
Timeframe: Baseline, Speculum Insertion, at Paracervical block injection, After dilation, End of procedure, 30 minutes after procedure
| Intervention | mm (Mean) | |||||
|---|---|---|---|---|---|---|
| expected level of pain during procedure | after speculum insertion | during paracervical block administration | after cervical dilation | immediately after procedure | 30 min after procedure | |
| Paracervical Block With Ketorolac and Lidocaine | 51.7 | 32.7 | 46.0 | 59.8 | 64.3 | 17.6 |
| Paracervical Block With Lidocaine | 52.2 | 33.6 | 50.8 | 74.8 | 61.5 | 21.8 |
"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.
| Intervention | participants reporting pain (Number) |
|---|---|
| Lidocaine | 11 |
| Magnesium | 25 |
| Lidocaine/Magnesium | 15 |
| Control | 18 |
Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.
| Intervention | percentage of patients reporting pain (Number) |
|---|---|
| Lidocaine | 29 |
| Magnesium | 57 |
| Lidocaine/Magnesium | 41 |
| Control | 46 |
Pain is measured on a visual analog scale 0=no pain and 10=worst pain imaginable. (NCT02268955)
Timeframe: 120 minutes post medication administration
| Intervention | score on a scale (Median) |
|---|---|
| Control Group: Adults Age 18-55 Years | 3.0 |
| IV Ibuprofen: Adults Age 18-55 Years | 0.3 |
"The primary endpoint is the pain reported by subjects, using the NRS-Pain with movement on the second day after surgery.The assumption behind this study is that certain genetic variants (e.g. single-nucleotide polymorphism (SNP) are responsible for part of total variation of certain clinical phenotypes (e.g. post-operative pain here).~Numeric Rating Score Pain Assessment (0-10 scale where 0 indicates no pain at all and 10 indicates the worst pain imaginable) on Post Op Day 2, Pain with Movement" (NCT01557751)
Timeframe: Postoperative day (POD) 2
| Intervention | units on a scale (Mean) |
|---|---|
| Total Knee Arthroplasty Subjects Who Are Genotyped | 2.83 |
OOWS: Is a 13-item instrument of documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score = 13, minimum score = 0. Lower scores correspond to fewer symptoms. (NCT01222091)
Timeframe: Pretreatment [90 min prior to 60-min REM infusion]; 30 min prior to 60-min REM infusion; 15 and 40 min after start of 60-min REM infusion; 5, 15, and 75 minutes after finish of 60-min REM infusion)
| Intervention | units on a scale (Mean) | ||||||
|---|---|---|---|---|---|---|---|
| Pretreatment | 30 min prior to REM infusion | 15 min after start of REM infusion | 40 min after start of REM infusion | 5 minutes after finish of REM infusion | 15 minutes after finish of REM infusion | 75 minutes after finish of REM infusion | |
| Placebo | 1.1 | 1.1 | 0.8 | 0.5 | 1.8 | 2.1 | 1.6 |
| Propranolol | 1.2 | 1.1 | 0.1 | 0.8 | 3 | 2.8 | 1.7 |
A slightly modified version of a previously described model of secondary hyperalgesia was used. Two copper wires contained in a microdialysis catheter were inserted in parallel over a length of 5 mm into the dermis of the right volar forearm. The wires were connected to a constant current stimulator controlled by a pulse generator to deliver rectangular and monophasic pulses with a duration of 0.5 mg at 2 Hz. Over a period of 15 min, the current was increased by targeting a pain rating of 5 on an 11-point numeric rating scale (0 = no pain and 10 = maximum tolerable pain) until the hyperalgesic area surrounding the stimulation site was fully established. Once the area was established, the current was held constant. Percent change from baseline in size (area) of secondary hyperalgesia after cessation of remifentanil infusion was calculated per group. (NCT01222091)
Timeframe: Baseline; 15 min post remifentanil (REM) infusion; 60 min post REM infusion
| Intervention | percentage of change (Number) | |
|---|---|---|
| 15 min post remifentanil infusion | 60 min post remifentanil infusion | |
| Placebo | -34 | 141.5 |
| Propranolol | -28 | -19 |
Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days
| Intervention | Days (Median) |
|---|---|
| Inhaled Nitric Oxide | 4.06 |
| Placebo | 3.11 |
(NCT00094887)
Timeframe: within 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 5 |
| Placebo | 7 |
Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Inhaled Nitric Oxide | 8 |
| Placebo | 7 |
"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days
| Intervention | Hours (Median) |
|---|---|
| Inhaled Nitric Oxide | 61.83 |
| Placebo | 55.16 |
The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| during first 24 hours | during 30-day follow-up | |
| Inhaled Nitric Oxide | 0 | 9 |
| Placebo | 0 | 17 |
The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days
| Intervention | mg (Median) | |
|---|---|---|
| within 8 hours | within 40 days | |
| Inhaled Nitric Oxide | 16.25 | 153.75 |
| Placebo | 17.25 | 211.37 |
13 reviews available for ketorolac and Ache
| Article | Year |
|---|---|
Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis.
Topics: Caffeine; Dexamethasone; Diclofenac; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Pain; Ph | 2022 |
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; C | 2022 |
Comparison of different nonsteroidal anti-inflammatory drugs for cesarean section: a systematic review and network meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cesarean Section; Diclofenac; Female; Humans; In | 2023 |
The effect of adjuvants added to local anaesthetics for single-injection upper extremity peripheral regional anaesthesia: A systematic review with network meta-analysis of randomised trials.
Topics: Anesthesia, Conduction; Anesthetics, Local; Dexamethasone; Dexmedetomidine; Humans; Ketorolac; Midaz | 2023 |
Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis.
Topics: Analgesia; Child; Fentanyl; Humans; Ketamine; Ketorolac; Pain | 2023 |
Ketorolac, Oxymorphone, Tapentadol, and Tramadol: A Comprehensive Review.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Oxymorphone; Pain; P | 2017 |
Narrative review shows that the short-term use of ketorolac is safe and effective in the management of moderate-to-severe pain in children.
Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Humans; Infant; Ketor | 2018 |
Injectable Nonsteroidal Anti-Inflammatory Drugs in Sport.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Athletes; Athletic Injuries; Humans; Inflammation; Injectio | 2018 |
Intranasal ketorolac: for short-term pain management.
Topics: Administration, Intranasal; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as | 2012 |
Evidence-based emergency medicine. Update: do ophthalmic nonsteroidal anti-inflammatory drugs reduce the pain associated with simple corneal abrasion without delaying healing?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Age | 2003 |
Myth: parenteral ketorolac provides more effective analgesia than oral ibuprofen.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Emergency Service, Hospital; Humans; | 2007 |
Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management.
Topics: Analgesics, Non-Narcotic; Humans; Ketorolac; Pain; Tolmetin | 1997 |
Intravenous analgesia.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Critical Care; Humans; Inje | 1999 |
50 trials available for ketorolac and Ache
| Article | Year |
|---|---|
Intranasal ketorolac versus intravenous ketorolac for treatment of migraine headaches in children: A randomized clinical trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Double-Blind Method; Humans; Ketorolac; Migraine Dis | 2022 |
Pain control and reduction of opioid use associated with intracameral phenylephrine1.0%-ketorolac 0.3% administered during cataract surgery.
Topics: Analgesics, Opioid; Cataract; Double-Blind Method; Epinephrine; Fentanyl; Humans; Ketorolac; Pain; P | 2022 |
Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Dexamethasone; Double-Blin | 2022 |
Comparison of the effect of ketorolac versus triamcinolone acetonide injections for the treatment of de Quervain's tenosynovitis: a double-blind randomized controlled trial.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; De Quervain Disease; Humans; Keto | 2022 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor | 2023 |
Effect of Preoperative Oral Steroids in Comparison to Anti-inflammatory on Anesthetic Success of Inferior Alveolar Nerve Block in Mandibular Molars with Symptomatic Irreversible Pulpitis-A Double-blinded Randomized Clinical Trial.
Topics: Anesthesia, Dental; Anesthetics, Local; Anti-Inflammatory Agents; Dexamethasone; Double-Blind Method | 2023 |
Ketorolac Is Not More Effective Than Flunixin Meglumine or Phenylbutazone in Reducing Foot Pain in Horses.
Topics: Animals; Clonixin; Cross-Over Studies; Horse Diseases; Horses; Ketorolac; Lameness, Animal; Pain; Ph | 2020 |
Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study.
Topics: Adult; Analgesics; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Metho | 2019 |
Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial.
Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non- | 2019 |
Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department.
Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2014 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration | 2015 |
Comparisons of ice packs, hot water immersion, and analgesia injection for the treatment of centipede envenomations in Taiwan.
Topics: Adult; Analgesics, Opioid; Animals; Arthropod Venoms; Arthropods; Cold Temperature; Cryotherapy; Fem | 2009 |
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non | 2009 |
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non | 2009 |
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non | 2009 |
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non | 2009 |
A novel drug eluting ureteral stent: a prospective, randomized, multicenter clinical trial to evaluate the safety and effectiveness of a ketorolac loaded ureteral stent.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug-Eluting | 2010 |
Effects of intrathecal ketorolac on human experimental pain.
Topics: Adolescent; Adult; Capsaicin; Female; Hot Temperature; Humans; Injections, Spinal; Ketorolac; Male; | 2010 |
Acetaminophen plus codeine compared to ketorolac in polytrauma patients.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, | 2010 |
Nitric oxide is negatively correlated to pain during acute inflammation.
Topics: Acute Disease; Adolescent; Adult; Female; Gene Expression Regulation, Enzymologic; Humans; Inflammat | 2010 |
The efficacy of intravenous ketorolac for pain relief in single-stage adjustable strabismus surgery: a prospective, randomized, placebo-controlled trial.
Topics: Adolescent; Adult; Analgesia; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cycloox | 2011 |
Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans.
Topics: Adult; Analgesics, Opioid; Blood Pressure; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Bli | 2011 |
Noninfiltrative anesthesia for transrectal prostate biopsy: a randomized prospective study comparing lidocaine-prilocaine cream and lidocaine-ketorolac gel.
Topics: Administration, Rectal; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, N | 2013 |
A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cross-Over | 2011 |
Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy.
Topics: Administration, Rectal; Aged; Anesthetics, Combined; Anesthetics, Local; Biopsy; Cyclooxygenase Inhi | 2012 |
Effect of ketorolac 0.5% drops on patients' pain perception during intravitreal injection procedure.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; | 2012 |
Effect of pretreatment with ketorolac on propofol injection pain.
Topics: Adult; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal | 2002 |
Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract Diseases; Colic; D | 2002 |
Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses.
Topics: Aged; Analgesia; Attitude to Health; Cognition; Conditioning, Operant; Consciousness; Female; Human | 2003 |
Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Ster | 2003 |
Effect of oral ketorolac and gender on human cold pressor pain tolerance.
Topics: Administration, Oral; Adult; Analysis of Variance; Cold Temperature; Cross-Over Studies; Double-Blin | 2003 |
Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Double-Blind Method; Female | 2004 |
Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Double-Blind Method; Female | 2004 |
Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Double-Blind Method; Female | 2004 |
Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Double-Blind Method; Female | 2004 |
Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects.
Topics: Adult; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Endoscopy, Gastrointestinal; | 2004 |
Appropriately timed analgesics control pain due to chest tube removal.
Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Chest Tubes | 2004 |
Intravenous ketorolac significantly reduces the pain of office transrectal ultrasound and prostate biopsies.
Topics: Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, Needle; Humans; Injections, Intravenous; | 2004 |
The effect of intravenous ketorolac on capsaicin-induced deep tissue hyperalgesia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cross-Over Studies; Double-Blind Method; | 2006 |
Topical ketorolac 0.5% for ocular pain relief during scatter laser photocoagulation with 532 nm green laser.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diabetic Retinopathy; | 2006 |
Intravenous regional anesthesia using lidocaine and ketorolac.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Conduction; Anesthesia, Intravenous; Anti-Infla | 1995 |
Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; | 1995 |
Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning.
Topics: Analgesics, Non-Narcotic; Bupivacaine; Combined Modality Therapy; Female; Humans; Ketorolac; Laparos | 1995 |
Prilocaine reduces injection pain caused by propofol.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anesthesia, Intravenous; Anti-Inflammatory Agents, Non-Steroi | 1995 |
Clinical experience with ketorolac in children.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Drug Administra | 1994 |
Use of ketorolac in the prevention of suxamethonium myalgia.
Topics: Adolescent; Adult; Analgesics; Atracurium; Female; Follow-Up Studies; Humans; Ketorolac; Male; Middl | 1994 |
Ketorolac as a premedicant for coronary artery bypass surgery patients with normal ventricles.
Topics: Aged; Analgesics; Blood Gas Analysis; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Ket | 1993 |
Subcutaneous ketorolac--a new development in pain control.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Female; | 1993 |
Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial.
Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; | 1996 |
The effect of pretreatment with ketorolac on pain during intravenous injection of propofol.
Topics: Adult; Ambulatory Surgical Procedures; Analgesics; Anesthetics, Intravenous; Double-Blind Method; Fe | 1996 |
Effects of ketorolac versus bupivacaine coadministration during patient-controlled hydromorphone epidural analgesia after thoracotomy procedures.
Topics: Aged; Analgesia, Epidural; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Bupiva | 1997 |
Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Blood Vessels; Child; Double-Blind | 1999 |
Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non- | 2000 |
Pain responses in methadone-maintained opioid abusers.
Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon | 2000 |
Pain responses in methadone-maintained opioid abusers.
Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon | 2000 |
Pain responses in methadone-maintained opioid abusers.
Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon | 2000 |
Pain responses in methadone-maintained opioid abusers.
Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon | 2000 |
Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cost-Benefit A | 2000 |
Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect.
Topics: Acute Disease; Adult; Analgesics; Anemia, Sickle Cell; Double-Blind Method; Emergencies; Female; Hum | 1992 |
96 other studies available for ketorolac and Ache
| Article | Year |
|---|---|
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and related compounds.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Male; Mice; Pain; Pyrroles; Rats; Structure-Ac | 1985 |
Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Edem | 2009 |
Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents.
Topics: Analgesics; Animals; Carbamates; Esters; Mice; Molecular Structure; Morphine; Pain; Pain Measurement | 2012 |
Isobolographic analysis of antinociceptive effect of ketorolac, indomethacin, and paracetamol after simultaneous peripheral local and systemic administration.
Topics: Acetaminophen; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Dr | 2022 |
Comparison of postcataract surgery anti-inflammatory regimens on the incidence of cystoid macular edema, iritis, pain, and photophobia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cataract; Dexamethasone; Humans; Incidence; Iritis; Ketorol | 2023 |
Predictors and Trends of Opioid-Sparing Radical Prostatectomy From a Large National Cohort.
Topics: Acetaminophen; Analgesics, Opioid; Bupivacaine; Humans; Ketorolac; Male; Pain; Prostatectomy; Roboti | 2022 |
An analysis of harms reporting in systematic reviews regarding ketorolac for management of perioperative pain.
Topics: Analgesics, Opioid; Humans; Ketorolac; Ketorolac Tromethamine; Pain; Research Design; Systematic Rev | 2022 |
Nitric Oxide and Opioids Involvement in Isobolographic Nsaids Antinociception.
Topics: Acetaminophen; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase | 2019 |
Platelet Function: Meloxicam Intravenous in Whole Blood Samples From Healthy Volunteers.
Topics: Adenosine Diphosphate; Administration, Intravenous; Adult; Anti-Inflammatory Agents, Non-Steroidal; | 2020 |
Ketorolac used to control pain after photorefractive keratectomy.
Topics: Humans; Ketorolac; Lasers, Excimer; Pain; Pain Management; Photorefractive Keratectomy | 2020 |
Effect of intracameral phenylephrine 1.0%-ketorolac 0.3% on postoperative cystoid macular edema, iritis, pain, and photophobia after cataract surgery.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cataract; Cataract Extraction; Cohort Studies; Humans; Irit | 2020 |
Perioperative pain control and tympanostomy tube outcomes.
Topics: Child, Preschool; Fentanyl; Humans; Infant; Ketorolac; Middle Ear Ventilation; Otitis Media with Eff | 2020 |
Brachial plexus block versus wide-awake local anaesthesia for open reduction internal fixation surgery in distal radius fracture: A preliminary retrospective report.
Topics: Adult; Anesthesia, Local; Anti-Inflammatory Agents, Non-Steroidal; Brachial Plexus Block; Female; Fr | 2021 |
Synergistic antinociceptive interaction of Syzygium aromaticum or Rosmarinus officinalis coadministered with ketorolac in rats.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; Female; Herb-Drug Interactions; Ketorol | 2017 |
Lidocaine/ketorolac-loaded biodegradable nanofibrous anti-adhesive membranes that offer sustained pain relief for surgical wounds.
Topics: Adhesives; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biocompatible Mater | 2017 |
Mucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application.
Topics: Adolescent; Adult; Alginates; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Drug Deli | 2018 |
Antinociceptive tolerance to NSAIDs in the anterior cingulate cortex is mediated via endogenous opioid mechanism.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Tolerance; Gyrus Cing | 2018 |
A randomized controlled trial comparing ketorolac and triamcinolone injections in adults with trigger digits.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Injections; | 2018 |
Magnetic field distribution modulation of intrathecal delivered ketorolac iron-oxide nanoparticle conjugates produce excellent analgesia for chronic inflammatory pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Inflammation; Injections, Spinal; Ketorolac; Magne | 2018 |
Effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam.
Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Diazepam; Electric Stimulation; Ketoro | 2019 |
Response to Schiavenato, von Baeyer, and Craig's letter to the editor.
Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce | 2013 |
The CGRP receptor antagonist BIBN4096BS peripherally alleviates inflammatory pain in rats.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behav | 2013 |
Iontophoretic transport kinetics of ketorolac in vitro and in vivo: demonstrating local enhanced topical drug delivery to muscle.
Topics: Administration, Cutaneous; Animals; Drug Delivery Systems; Humans; Iontophoresis; Ketorolac; Kinetic | 2014 |
Pharmacokinetics and analgesic effect of ketorolac floating delivery system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Drug Delivery Systems; | 2015 |
Antinociceptive tolerance to NSAIDs microinjected into dorsal hippocampus.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Diclofenac; | 2014 |
Management of stent symptoms: what a pain!
Topics: Cholinergic Antagonists; Humans; Ketorolac; Pain; Stents; Ureter; Ureteroscopy | 2014 |
Pain and satisfaction during rigid cystoscopic ureteral stent removal: a preliminary study.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Cross-Sectional Studies; Cystoscopy; Device Removal; H | 2014 |
Factors Associated With Discharge After Initial Emergency Treatment of Pediatric Migraine.
Topics: Administration, Intranasal; Administration, Intravenous; Administration, Oral; Adolescent; Analgesic | 2017 |
Contemporary open ureteral reimplantation without morphine: assessment of pain and outcomes.
Topics: Analgesics; Child, Preschool; Female; Humans; Ketorolac; Male; Minimally Invasive Surgical Procedure | 2009 |
Sample size/power calculations for repeated ordinal measurements in population pharmacodynamic experiments.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Computer Simulation; Humans; Ketorolac; Models, Statistical | 2010 |
Editorial comment.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug-Eluting Stents; Humans; Ketorolac; Pain; Ureter; Urete | 2010 |
Re: a novel drug eluting ureteral stent: a prospective, randomized, multicenter clinical trial to evaluate the safety and effectiveness of a ketorolac loaded ureteral stent: A. E. Krambeck, R. S. Walsh, J. D. Denstedt, G. M. Preminger, J. Li, J. C. Evans
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug-Eluting Stents; Humans; Ketorolac; Multicenter Studies | 2010 |
Hesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chromatography, High Pressu | 2011 |
Pediatric nurses' beliefs and pain management practices: an intervention pilot.
Topics: Analgesics; Feasibility Studies; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Pilo | 2011 |
Opioid sensitivity of nucleus raphe magnus ater analgesia by nonsteroidal anti-inflammatory drugs.
Topics: Analgesia; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug Inte | 2011 |
Bridging the gap between pain assessment and treatment: time for a new theoretical approach?
Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce | 2011 |
Self-report is a primary source of information about pain, but it is not infallible: a comment on "response to Voepel-Lewis's letter to the editor, 'bridging the gap between pain assessment and treatment: time for a new theoretical approach?'".
Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce | 2013 |
Comparison of stone size and response to analgesic treatment in predicting outcome of patients with renal colic.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Colic; Emergency Service, Hospital; Fem | 2002 |
Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Dose-Response Relationship | 2003 |
An evaluation of population D-optimal designs via pharmacokinetic simulations.
Topics: AIDS Vaccines; Algorithms; Asthma; Clinical Trials as Topic; Computer Simulation; Dose-Response Rela | 2003 |
Management of vaso-occlusive pain in children with sickle cell disease.
Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anemia, Sickle Cell; Anti-Infl | 2003 |
Ketorolac may control more than pain.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Burns; Humans; Ketorolac; Pain; Respiratory Distress Syndro | 2003 |
Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats.
Topics: Animals; Cervix Uteri; Cyclooxygenase Inhibitors; Dilatation; Electromyography; Estrogens; Female; I | 2003 |
Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury.
Topics: Animals; Behavior, Animal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2003 |
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2004 |
Nonsteroidal anti-inflammatory drugs increase expression of inducible COX-2 isoform of cyclooxygenase in spinal cord of rats with adjuvant induced inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhi | 2004 |
A pilot study on the efficacy of ketorolac plus tramadol infusion combined with erythrocytapheresis in the management of acute severe vaso-occlusive crises and sickle cell pain.
Topics: Adolescent; Analgesics; Anemia, Sickle Cell; Child; Child, Preschool; Combined Modality Therapy; Cyt | 2004 |
Pain relief in those recovering from chemical dependency.
Topics: Administration, Inhalation; Albuterol; Anti-Inflammatory Agents, Non-Steroidal; Bronchodilator Agent | 2004 |
Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Age | 2005 |
Simplifying prehospital analgesia. Why certain medications should or should not be used for pain management in the field.
Topics: Analgesics; Anesthetics, Combined; Butorphanol; Emergency Medical Services; Emergency Medical Techni | 2005 |
The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception.
Topics: Analgesia; Analgesics, Opioid; Animals; Antineoplastic Agents; Behavior, Animal; Bone Neoplasms; Che | 2006 |
Quantification of analgesic use in children with sickle cell disease.
Topics: Adolescent; Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; Anti-Inflammatory Agents, No | 2007 |
The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dipyrone; Disease | 2007 |
Pharmacological validation of a model of cystitis pain in the mouse.
Topics: Analgesics; Animals; Behavior, Animal; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Resp | 2007 |
Intraoperative analgesia for day-care surgery: practice trends.
Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesia; Analgesics; Analgesics, Non-Narcotic; Anal | 2007 |
Ketorolac-dextran conjugates: synthesis, in vitro and in vivo evaluation.
Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buffers; Carrag | 2007 |
The effects of intrathecal cyclooxygenase-1, cyclooxygenase-2, or nonselective inhibitors on pain behavior and spinal Fos-like immunoreactivity.
Topics: Animals; Behavior, Animal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2008 |
Spontaneously breathing technique for opioid tolerance.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Inhalation; Anti-Inflammatory | 2008 |
The analgesic and anti-inflammatory profile of (+/-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619).
Topics: Adrenal Cortex Hormones; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, No | 1982 |
Effects of morphine and ketorolac on thermal allodynia induced by prostaglandin E2 and bradykinin in rhesus monkeys.
Topics: Analgesics, Non-Narcotic; Animals; Azocines; Bradykinin; Dinoprostone; Female; Ketorolac; Macaca mul | 1995 |
The use of ketorolac in lumbar spine surgery: a cost-benefit analysis.
Topics: Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Cost-Benefit Analysis; Drug Costs; Female; Hosp | 1995 |
Ketorolac potentiates morphine antinociception during visceral nociception in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Dose-Response Relationship, Dru | 1994 |
NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-St | 1994 |
Meperidine and ketorolac in the treatment of painful sickle cell crisis.
Topics: Analgesics; Anemia, Sickle Cell; Humans; Ketorolac; Meperidine; Pain; Tolmetin | 1993 |
Antinociceptive activity of intrathecal ketorolac is blocked by the kappa-opioid receptor antagonist, nor-binaltorphimine.
Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Injections, Spinal; Ketorolac; Male; Mice; M | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin | 1993 |
Comparison of the analgesic effects of ketorolac, morphine and aspirin in the rat.
Topics: Analgesics; Animals; Aspirin; Dose-Response Relationship, Drug; Female; Ketorolac; Morphine; Pain; P | 1993 |
Pain management with intravenous ketorolac.
Topics: Adenocarcinoma; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bile Duct Neoplasms; Chr | 1993 |
Treatment of resistant pain in hypertrophic pulmonary arthropathy with ketorolac.
Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamous Cell; | 1993 |
NSAIDs and balanced analgesia.
Topics: Analgesia; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Female; Humans; Infant; Ketor | 1993 |
Problems and pitfalls in providing acute and short-term pain relief with nonsteroidal anti-inflammatory agents.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Drug Int | 1996 |
The effect of pretreatment with ketorolac on pain during intravenous injection of propofol.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Pain; Propofol | 1997 |
If you have no destination, any road will do.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Ketorolac; Mus | 1998 |
Drugs for pain.
Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics | 1998 |
Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Biotransformation; Dise | 1998 |
Spinal action of ketorolac, S(+)- and R(-)-ibuprofen on non-noxious activation of the catechol oxidation in the rat locus coeruleus: evidence for a central role of prostaglandins in the strychnine model of allodynia.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Catechols; Electrophys | 1999 |
Cross sensitivities. Medication errors waiting to happen.
Topics: Analgesics, Non-Narcotic; Aspirin; Asthma; Cross Reactions; Drug Hypersensitivity; Drug Interactions | 1999 |
Effect of coadministration of caffeine and either adenosine agonists or cyclic nucleotides on ketorolac analgesia.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Administration, Topical; Analgesics, Non-Narcotic; Animals; | 1999 |
Analgesia for termination of pregnancy.
Topics: Abortion, Induced; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Ketorolac; P | 1999 |
Drugs for pain.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 2000 |
Ketorolac versus morphine for severe pain. Ketorolac is more effective, cheaper, and has fewer side effects.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Costs; Humans; Ketorolac; Morphine | 2000 |
Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Capsai | 2001 |
Treatment of vinorelbine-associated tumor pain.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Bone Neoplasms; F | 2001 |
Participation of the nitric oxide-cyclic GMP-ATP-sensitive K(+) channel pathway in the antinociceptive action of ketorolac.
Topics: Adenosine Triphosphate; Analgesics; Animals; Behavior, Animal; Cyclic AMP; Dose-Response Relationshi | 2001 |
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department.
Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory | 1992 |
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
Ketorolac in the treatment of acute pain: the pendulum swings.
Topics: Acute Disease; Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
Relief of pain by ketorolac or alcohol?
Topics: Analgesics; Autonomic Nerve Block; Autonomic Nervous System Diseases; Ethanol; Humans; Injections, I | 1992 |
[Introductory Press Conference: Toratex--the new mono-analgesics in acute, intense pain. Frankfurt, 21 February 1992].
Topics: Acute Disease; Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1992 |
Use of ketorolac in sickle-cell disease and vaso-occlusive crisis.
Topics: Adult; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Pain | 1991 |
[Associated symposium: Ketorolac in drug therapy for pain relief. Berlin, October 25, 1991].
Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin | 1991 |
Intravenous regional block using ketorolac: preliminary results in the treatment of reflex sympathetic dystrophy.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Injections, Intravenous; Ketorolac; | 1992 |
[Treatment of moderate and severe pain. Ketorolac--a new analgesic].
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Ketorolac; P | 1991 |
Place of ketorolac in pain management.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Pain; Tolmetin | 1990 |