Page last updated: 2024-10-29

ketorolac and Ache

ketorolac has been researched along with Ache in 159 studies

Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)
ketorolac : A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid : A member of the class of pyrrolizines that is 2,3-dihydro-1H-pyrrolizine which is substituted at positions 1 and 5 by carboxy and benzoyl groups, respectively.

Research Excerpts

ExcerptRelevanceReference
"The aim of this prospective, double-blind, randomized controlled trial was to compare the effect of oral premedication of meloxicam, ketorolac, dexamethasone, ibuprofen, or placebo on the success of inferior alveolar nerve blocks (IANB) of mandibular posterior teeth in patients experiencing symptomatic irreversible pulpitis."9.69Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial. ( Elnaghy, AM; Elsaka, SE; Elshazli, AH, 2023)
"Intravenous ketorolac is commonly used for treating migraine headaches in children."9.51Intranasal ketorolac versus intravenous ketorolac for treatment of migraine headaches in children: A randomized clinical trial. ( Babineau, SE; Carter, RC; Chernick, LS; Dayan, PS; DePeter, KC; Fan, W; Friedman, BW; Gonzalez, AE; Kwok, MY; Lubell, TR; McLaren, SH; Roskind, CG; Tsze, DS, 2022)
"To compare pain and the need for the opioid fentanyl use associated with the administration of phenylephrine 1."9.51Pain control and reduction of opioid use associated with intracameral phenylephrine1.0%-ketorolac 0.3% administered during cataract surgery. ( Donnenfeld, ED; Mychajlyszyn, A; Mychajlyszyn, D; Stein, R, 2022)
" The purpose of this study was to evaluate the effects of adding dexamethasone to ketorolac on pain control in acute renal colic."9.51Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial. ( Farrokhi, E; Haghighi, R; Hosseini, SS; Lotfabadi, P; Rameshrad, M; Razi, A; Saadati, H, 2022)
"Our study found that ketorolac injections resulted in inferior pain reduction, functional score and grip improvement than triamcinolone injection in patients with radial styloid tenosynovitis."9.51Comparison of the effect of ketorolac versus triamcinolone acetonide injections for the treatment of de Quervain's tenosynovitis: a double-blind randomized controlled trial. ( Chuaychoosakoon, C; Fongsri, W; Suwannaphisit, S; Suwanno, P, 2022)
"In this double-blind clinical trial study, the patients with renal colic pain were randomly divided into 2 groups; Group I received an intravenous infusion of 30 mg of Ketorolac and normal saline as placebo, Group II 50 mg/kg magnesium sulphate 50%/100 ml normal plus 30 mg of Ketorolac."9.30Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study. ( Aryan, A; Fahimi, MA; Maleki Verki, M; Motamed, H; Porozan, S, 2019)
"To compare the safety and efficacy of xylocaine gel and ketorolac as opioid-sparing analgesia compared with pethidine for shock wave lithotripsy (SWL) pain."9.30Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial. ( Abol-Enein, H; Atwa, AM; El-Assmy, A; Elbaset, MA; Fadallah, M; Ghobrial, FK; Hashem, A; Laymon, M; Sheir, KZ, 2019)
"To evaluate intramuscular ketorolac compared with placebo saline injection for pain control with intrauterine device (IUD) placement."9.20Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial. ( Mody, SK; Ngo, LL; Ward, KK, 2015)
"Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain."9.19Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014)
"What's known on the subject? and What does the study add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal prostate biopsy, but not pain due to periprostatic infiltration."9.16Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2012)
"To determine the efficacy of preoperative intravenous ketorolac in reducing intraoperative and postoperative pain and improving patient satisfaction in patients undergoing single-stage adjustable strabismus surgery."9.15The efficacy of intravenous ketorolac for pain relief in single-stage adjustable strabismus surgery: a prospective, randomized, placebo-controlled trial. ( Bae, SJ; Chang, JH; Chung, SA; Kim, WK; Lee, JB; Rhiu, S, 2011)
"Topical ketorolac tromethamine usage is no more effective than artificial tears for pain relief during posterior segment laser procedures in proliferative diabetic retinopathy patients."9.12Topical ketorolac 0.5% for ocular pain relief during scatter laser photocoagulation with 532 nm green laser. ( Esgin, H; Samut, HS, 2006)
"We compare the effectiveness of intravenous ketorolac and intravenous prochlorperazine in the treatment of pediatric migraine headaches."9.11Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac. ( Anderson, AC; Brousseau, DC; Duffy, SJ; Linakis, JG, 2004)
" 15 and 30 mg ketorolac reduces pain following propofol injection."9.10Effect of pretreatment with ketorolac on propofol injection pain. ( Buerkle, H; Chou, AK; Huang, YW; Lee, TH; Lin, CR; Lin, SH; Lu, CY; Muhammad, R; Yang, LC, 2002)
"Patients receiving ketorolac and those receiving placebo were of similar age, weight, gender, number of prior ED visits, number of prior hospital admissions, duration of pain prior to presentation, and initial pain score."9.09Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis. ( Givens, TG; Hardwick, WE; King, WD; Lawley, D; Monroe, KW, 1999)
"We performed a randomised, double-blind, prospective trial to discover whether intravenous ketorolac 10 mg made up to 2 ml with saline, with or without venous occlusion for 2 min, reduces the pain on injection of propofol."9.09Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol. ( Barkshire, KF; Dexter, T; Yull, DN, 2000)
"To investigate the cost effectiveness of intravenous ketorolac compared with intravenous morphine in relieving pain after blunt limb injury in an accident and emergency department."9.09Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. ( Cheung, NK; Cocks, RA; Jacobs, P; Lam, PK; Ng, YC; Rainer, TH; Tam, M; Wong, R, 2000)
"To evaluate the efficacy of IM ketorolac versus that of oral ibuprofen in acute musculoskeletal pain."9.08Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995)
"To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning."9.08Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995)
"Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion."9.08Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995)
"25% bupivacaine without epinephrine to those of normal saline on chest tube removal pain in cardiothoracic surgery patients."9.08Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial. ( Puntillo, KA, 1996)
"A randomised, double-blind, controlled trial was undertaken to compare three different methods of reducing pain during the intravenous injection of propofol."9.08The effect of pretreatment with ketorolac on pain during intravenous injection of propofol. ( Power, I; Smith, AJ, 1996)
"To determine if a single dose of intramuscular ketorolac given on presentation to the emergency department has a narcotic-sparing effect in adult patients with sickle cell vaso-occlusive crisis pain."9.07Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992)
"Ketorolac is a member of the pyrrolo-pyrrole group of NSAIDs, and has been available in several formulations for some time, for the treatment of pain."8.88Intranasal ketorolac: for short-term pain management. ( Garnock-Jones, KP, 2012)
"In May 2022, we conducted a search of major databases, MEDLINE (PubMed and Ovid), Embase, Epistemonikos, and the Cochrane Database of Systematic Reviews to identify eligible SRs on ketorolac for perioperative pain."8.12An analysis of harms reporting in systematic reviews regarding ketorolac for management of perioperative pain. ( Flores, H; Garrett, M; Kee, M; Magee, T; Modi, J; Roberts, W; Rucker, B; Vassar, M; Wise, A, 2022)
"To assess the effectiveness of intracameral phenylephrine-ketorolac during cataract surgery compared with postoperative topical steroids in reducing the incidence of postoperative clinical cystoid macular edema (CME) confirmed via optical coherence tomography (OCT), breakthrough iritis, pain, and photophobia."7.96Effect of intracameral phenylephrine 1.0%-ketorolac 0.3% on postoperative cystoid macular edema, iritis, pain, and photophobia after cataract surgery. ( Bedi, R; Visco, DM, 2020)
" All patients received ketorolac and acetaminophen with codeine for pain, and early in the series 7 patients received morphine."7.75Contemporary open ureteral reimplantation without morphine: assessment of pain and outcomes. ( Chamie, K; Chi, A; Hu, B; Keegan, KA; Kurzrock, EA, 2009)
"This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain."7.73Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005)
"We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain."7.70Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998)
"To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain."7.68Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993)
"Ketorolac tromethamine was not superior to FM or PB in reducing lameness using a HBS model."6.94Ketorolac Is Not More Effective Than Flunixin Meglumine or Phenylbutazone in Reducing Foot Pain in Horses. ( Brunner, TJ; Cooper, BR; Davern, AJ; Grady, SE; Lescun, TB; Moore, GE; Taylor, SD, 2020)
"Ketorolac or vehicle was instilled before the injection, and pain perception was recorded on a 0 to 100 Visual Analog Scale (VAS) immediately after the intravitreal administration."6.77Effect of ketorolac 0.5% drops on patients' pain perception during intravitreal injection procedure. ( Beredima, E; Georgakopoulos, CD; Makri, OE; Pharmakakis, NM; Vasilakis, PT, 2012)
"Pretreatment with parecoxib or ketorolac reduced the postinfusion area of pinprick hyperalgesia (P < 0."6.76Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans. ( Draegni, T; Heyerdahl, F; Lenz, H; Raeder, J; Schmelz, M; Stubhaug, A, 2011)
"ketorolac (10mg q."6.71Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003)
"Providing pain management for known opioid abusers is a challenging clinical task, in part because little is known about their pain experience and analgesic requirements."6.69Pain responses in methadone-maintained opioid abusers. ( Charuvastra, VC; Compton, P; Kintaudi, K; Ling, W, 2000)
" We found that gastrointestinal side effects were mainly reported with prolonged use, significant bleeding was reported in adenotonsillectomy, and adverse renal effects appeared to be limited to patients with specific coexisting risk factors."6.58Narrative review shows that the short-term use of ketorolac is safe and effective in the management of moderate-to-severe pain in children. ( Amoroso, S; Barbi, E; Calligaris, L; Marzuillo, P, 2018)
"Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) with strong analgesic activity."6.40Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. ( Brogden, RN; Gillis, JC, 1997)
"The aim of this prospective, double-blind, randomized controlled trial was to compare the effect of oral premedication of meloxicam, ketorolac, dexamethasone, ibuprofen, or placebo on the success of inferior alveolar nerve blocks (IANB) of mandibular posterior teeth in patients experiencing symptomatic irreversible pulpitis."5.69Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial. ( Elnaghy, AM; Elsaka, SE; Elshazli, AH, 2023)
"This randomized double-blinded trial aimed to compare the anesthetic success of inferior alveolar nerve blocks (IANBs) with 2% lidocaine in mandibular molars with symptomatic irreversible pulpitis (SIP) after oral premedication of prednisolone, dexamethasone, and ketorolac with placebo."5.69Effect of Preoperative Oral Steroids in Comparison to Anti-inflammatory on Anesthetic Success of Inferior Alveolar Nerve Block in Mandibular Molars with Symptomatic Irreversible Pulpitis-A Double-blinded Randomized Clinical Trial. ( Hegde, V; Kulkarni, V; Nagendrababu, V; Setzer, FC; Shaikh, S; Shanmugasundaram, S; Suresh, N, 2023)
"Intravenous ketorolac is commonly used for treating migraine headaches in children."5.51Intranasal ketorolac versus intravenous ketorolac for treatment of migraine headaches in children: A randomized clinical trial. ( Babineau, SE; Carter, RC; Chernick, LS; Dayan, PS; DePeter, KC; Fan, W; Friedman, BW; Gonzalez, AE; Kwok, MY; Lubell, TR; McLaren, SH; Roskind, CG; Tsze, DS, 2022)
"To compare pain and the need for the opioid fentanyl use associated with the administration of phenylephrine 1."5.51Pain control and reduction of opioid use associated with intracameral phenylephrine1.0%-ketorolac 0.3% administered during cataract surgery. ( Donnenfeld, ED; Mychajlyszyn, A; Mychajlyszyn, D; Stein, R, 2022)
" The purpose of this study was to evaluate the effects of adding dexamethasone to ketorolac on pain control in acute renal colic."5.51Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial. ( Farrokhi, E; Haghighi, R; Hosseini, SS; Lotfabadi, P; Rameshrad, M; Razi, A; Saadati, H, 2022)
"Our study found that ketorolac injections resulted in inferior pain reduction, functional score and grip improvement than triamcinolone injection in patients with radial styloid tenosynovitis."5.51Comparison of the effect of ketorolac versus triamcinolone acetonide injections for the treatment of de Quervain's tenosynovitis: a double-blind randomized controlled trial. ( Chuaychoosakoon, C; Fongsri, W; Suwannaphisit, S; Suwanno, P, 2022)
" Indomethacin was superior to celecoxib for pain score at rest at 8-12 h and celecoxib + parecoxib, diclofenac, and ketorolac for pain score on movement at 48 h."5.41Comparison of different nonsteroidal anti-inflammatory drugs for cesarean section: a systematic review and network meta-analysis. ( Blake, L; Carvalho, B; Carver, AL; Desai, N; Murdoch, I; O'Carroll, JE; Onwochei, DN; Sultan, P, 2023)
" Our review shows that: - There may be little or no difference in pain relief (single dose IN vs IV fentanyl MD 4 mm, 95% CI -8 to 16 at 30 min by 100 mm VAS; multiple doses IN vs IV fentanyl MD 0, 95%CI -0."5.41Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis. ( Austad, B; Iakovleva, E; Munblit, D; Pedersen, SA; Prescott, MG; Simpson, MR; Vallersnes, OM, 2023)
"Life-threatening acute respiratory distress syndrome (ARDS) complicates the recovery of patients with burn and inhalation injury."5.32Ketorolac may control more than pain. ( Isik, F, 2003)
"In this double-blind clinical trial study, the patients with renal colic pain were randomly divided into 2 groups; Group I received an intravenous infusion of 30 mg of Ketorolac and normal saline as placebo, Group II 50 mg/kg magnesium sulphate 50%/100 ml normal plus 30 mg of Ketorolac."5.30Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study. ( Aryan, A; Fahimi, MA; Maleki Verki, M; Motamed, H; Porozan, S, 2019)
"To compare the safety and efficacy of xylocaine gel and ketorolac as opioid-sparing analgesia compared with pethidine for shock wave lithotripsy (SWL) pain."5.30Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial. ( Abol-Enein, H; Atwa, AM; El-Assmy, A; Elbaset, MA; Fadallah, M; Ghobrial, FK; Hashem, A; Laymon, M; Sheir, KZ, 2019)
"This review was designated to evaluate the efficacy of parenteral ketorolac in treating acute migraine headache."5.22Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis. ( Abu Bakar, MA; Baharuddin, KA; Norhayati, MN; Nurathirah, MN; Yazid, MB, 2022)
"To evaluate intramuscular ketorolac compared with placebo saline injection for pain control with intrauterine device (IUD) placement."5.20Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial. ( Mody, SK; Ngo, LL; Ward, KK, 2015)
"Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain."5.19Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. ( Brunetti, C; Buccelletti, F; Conti, C; D'Aurizio, G; Franceschi, F; Genitiempo, M; Gilardi, E; Iacomini, P; Marrocco, R; Marsiliani, D; Merendi, G; Pola, E; Proietti, L; Rocchi, L; Zirio, G; Zuccalà, G, 2014)
"Lidocaine-prilocaine cream was most effective on probe-related pain, whereas lidocaine-ketorolac gel was most effective on sampling-related pain."5.17Noninfiltrative anesthesia for transrectal prostate biopsy: a randomized prospective study comparing lidocaine-prilocaine cream and lidocaine-ketorolac gel. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2013)
"What's known on the subject? and What does the study add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal prostate biopsy, but not pain due to periprostatic infiltration."5.16Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy. ( Bufo, P; Carrieri, G; Cormio, L; Lorusso, F; Pagliarulo, V; Perrone, A; Sanguedolce, F; Selvaggio, O, 2012)
"To determine the efficacy of preoperative intravenous ketorolac in reducing intraoperative and postoperative pain and improving patient satisfaction in patients undergoing single-stage adjustable strabismus surgery."5.15The efficacy of intravenous ketorolac for pain relief in single-stage adjustable strabismus surgery: a prospective, randomized, placebo-controlled trial. ( Bae, SJ; Chang, JH; Chung, SA; Kim, WK; Lee, JB; Rhiu, S, 2011)
" The aim was to explore the existence of a positive interaction between paracetamol 1 g and ketorolac 20 mg administered intravenously on experimental pain models in human beings."5.15A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination. ( Besson, M; Daali, Y; Dayer, P; Desmeules, J; Ing Lorenzini, K; Salomon, D, 2011)
"To study the effects of a paracervical block with combined ketorolac and lidocaine on perceived pain during first-trimester surgical abortion."5.14Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial. ( Burke, A; Cansino, C; Edelman, A; Jamshidi, R, 2009)
"Acetaminophen plus codeine is effective in pain control in polytrauma patients at least in our series."5.14Acetaminophen plus codeine compared to ketorolac in polytrauma patients. ( Buccelletti, F; Calcinaro, S; Carroccia, A; De Marco, G; Franceschi, F; Gentiloni Silveri, N; Giannuzzi, R; Gilardi, E; Giupponi, B; Mancini, F; Marini, M; Marsiliani, D; Merra, G; Potenza, A, 2010)
"Topical ketorolac tromethamine usage is no more effective than artificial tears for pain relief during posterior segment laser procedures in proliferative diabetic retinopathy patients."5.12Topical ketorolac 0.5% for ocular pain relief during scatter laser photocoagulation with 532 nm green laser. ( Esgin, H; Samut, HS, 2006)
"We compare the effectiveness of intravenous ketorolac and intravenous prochlorperazine in the treatment of pediatric migraine headaches."5.11Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac. ( Anderson, AC; Brousseau, DC; Duffy, SJ; Linakis, JG, 2004)
"No subjects treated with parecoxib sodium or placebo developed gastroduodenal ulcers or > or =11 erosions/ulcers."5.11Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects. ( Harris, SI; Hubbard, RC; LeComte, D; Stoltz, RR, 2004)
"If used correctly, either an opioid (morphine) or a nonsteroidal anti-inflammatory (ketorolac) can substantially reduce pain during chest tube removal without causing adverse sedative effects."5.11Appropriately timed analgesics control pain due to chest tube removal. ( Ley, SJ; Puntillo, K, 2004)
" 15 and 30 mg ketorolac reduces pain following propofol injection."5.10Effect of pretreatment with ketorolac on propofol injection pain. ( Buerkle, H; Chou, AK; Huang, YW; Lee, TH; Lin, CR; Lin, SH; Lu, CY; Muhammad, R; Yang, LC, 2002)
"Patients receiving ketorolac and those receiving placebo were of similar age, weight, gender, number of prior ED visits, number of prior hospital admissions, duration of pain prior to presentation, and initial pain score."5.09Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis. ( Givens, TG; Hardwick, WE; King, WD; Lawley, D; Monroe, KW, 1999)
"We performed a randomised, double-blind, prospective trial to discover whether intravenous ketorolac 10 mg made up to 2 ml with saline, with or without venous occlusion for 2 min, reduces the pain on injection of propofol."5.09Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol. ( Barkshire, KF; Dexter, T; Yull, DN, 2000)
"To investigate the cost effectiveness of intravenous ketorolac compared with intravenous morphine in relieving pain after blunt limb injury in an accident and emergency department."5.09Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial. ( Cheung, NK; Cocks, RA; Jacobs, P; Lam, PK; Ng, YC; Rainer, TH; Tam, M; Wong, R, 2000)
"To evaluate the efficacy of IM ketorolac versus that of oral ibuprofen in acute musculoskeletal pain."5.08Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. ( Paris, PM; Seaberg, DC; Turturro, MA, 1995)
"To determine whether postoperative pain and nausea after laparoscopic sterilization can be reduced with a combination of bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning."5.08Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning. ( Bradford, TH; Meeks, GR; Norman, PF; Robertson, K, 1995)
"Propofol, which is commonly used for outpatient anaesthesia, may evoke pain during infusion."5.08Prilocaine reduces injection pain caused by propofol. ( Eriksson, M, 1995)
"25% bupivacaine without epinephrine to those of normal saline on chest tube removal pain in cardiothoracic surgery patients."5.08Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial. ( Puntillo, KA, 1996)
"A randomised, double-blind, controlled trial was undertaken to compare three different methods of reducing pain during the intravenous injection of propofol."5.08The effect of pretreatment with ketorolac on pain during intravenous injection of propofol. ( Power, I; Smith, AJ, 1996)
"We studied the comparative effects of ketorolac versus bupivacaine supplementation of hydromorphone (HM) patient-controlled epidural analgesia (PCEA) on the HM requirement, postoperative pain, and pulmonary function in 62 consenting patients after thoracotomy procedures."5.08Effects of ketorolac versus bupivacaine coadministration during patient-controlled hydromorphone epidural analgesia after thoracotomy procedures. ( Bossard, RF; Singh, H; White, PF; Yeatts, RW, 1997)
"To determine if a single dose of intramuscular ketorolac given on presentation to the emergency department has a narcotic-sparing effect in adult patients with sickle cell vaso-occlusive crisis pain."5.07Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect. ( Mitchell, TR; Norris, RL; Wright, SW, 1992)
"Ketorolac is a member of the pyrrolo-pyrrole group of NSAIDs, and has been available in several formulations for some time, for the treatment of pain."4.88Intranasal ketorolac: for short-term pain management. ( Garnock-Jones, KP, 2012)
"Topical NSAIDs were found to be more effective in controlling CME, pain, iritis, and photophobia after cataract surgery compared with the intracanalicular dexamethasone insert in the presence of intracameral phenylephrine/ketorolac."4.31Comparison of postcataract surgery anti-inflammatory regimens on the incidence of cystoid macular edema, iritis, pain, and photophobia. ( Visco, DM, 2023)
"In May 2022, we conducted a search of major databases, MEDLINE (PubMed and Ovid), Embase, Epistemonikos, and the Cochrane Database of Systematic Reviews to identify eligible SRs on ketorolac for perioperative pain."4.12An analysis of harms reporting in systematic reviews regarding ketorolac for management of perioperative pain. ( Flores, H; Garrett, M; Kee, M; Magee, T; Modi, J; Roberts, W; Rucker, B; Vassar, M; Wise, A, 2022)
"To assess the effectiveness of intracameral phenylephrine-ketorolac during cataract surgery compared with postoperative topical steroids in reducing the incidence of postoperative clinical cystoid macular edema (CME) confirmed via optical coherence tomography (OCT), breakthrough iritis, pain, and photophobia."3.96Effect of intracameral phenylephrine 1.0%-ketorolac 0.3% on postoperative cystoid macular edema, iritis, pain, and photophobia after cataract surgery. ( Bedi, R; Visco, DM, 2020)
"Ketorolac is a reasonable non-narcotic alternative to fentanyl which provides equal pain control and does not increase tube occlusion rates."3.96Perioperative pain control and tympanostomy tube outcomes. ( Adil, E; Irace, AL; Kawai, K; Leung, P; Riley, B, 2020)
"The current study aimed to investigate the effectiveness of a developed sodium alginate and polyvinylpyrrolidone K-25 (PVP K-25) polymeric wafer for the co-delivery of ketorolac and lidocaine to soft tissues for healing and pain control following gingivectomy."3.88Mucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application. ( El-Feky, GS; Farouk Abdulmaguid, R; Kamel, R; Zayed, GM, 2018)
"The objective of the study was to investigate the iontophoretic delivery kinetics of ketorolac (KT), a highly potent NSAID and peripherally-acting analgesic that is currently indicated to treat moderate to severe acute pain."3.80Iontophoretic transport kinetics of ketorolac in vitro and in vivo: demonstrating local enhanced topical drug delivery to muscle. ( de Souza, JG; Gelfuso, GM; Gratieri, T; Kalia, YN; Lopez, RF; Pujol-Bello, E, 2014)
" Both pretreatment and post-treatment with the opioid antagonist naloxone into the DH significantly reduced the antinociceptive effect of NSAIDs in both pain models."3.80Antinociceptive tolerance to NSAIDs microinjected into dorsal hippocampus. ( Gurtskaia, G; Nebieridze, M; Nozadze, I; Tsagareli, MG; Tsiklauri, N, 2014)
"Considering the potential pain and dissatisfaction of rigid cystoscopic ureteral stent removal, procedures utilizing moderate sedation with midazolam or general anesthesia using propofol without muscle relaxation should be considered."3.80Pain and satisfaction during rigid cystoscopic ureteral stent removal: a preliminary study. ( Cho, SW; Choi, H; Kim, JH; Kim, MG; Park, SY; Song, D; Song, YS, 2014)
" All patients received ketorolac and acetaminophen with codeine for pain, and early in the series 7 patients received morphine."3.75Contemporary open ureteral reimplantation without morphine: assessment of pain and outcomes. ( Chamie, K; Chi, A; Hu, B; Keegan, KA; Kurzrock, EA, 2009)
"This prospective audit was undertaken in order to document the analgesic response and adverse effects of concurrent short-term ('burst') triple-agent analgesic (ketamine, an opioid and an anti-inflammatory agent--either steroidal or non-steroidal) administration, for episodes of acute on chronic pain."3.73Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain. ( Ashby, M; Good, P; Goodchild, C; Jackson, K; Tullio, F, 2005)
"Systemic lidocaine and other local anesthetics reduce hypersensitivity states induced by both acute inflammation and peripheral nerve injury in animals and produce analgesia in some patients with chronic pain."3.72Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac. ( Du, W; Eisenach, JC; Ma, W, 2003)
"We previously reported the up-regulation of cyclooxygenase 2 (COX2) in injured sciatic nerve of rats with partial sciatic nerve ligation (PSNL) and the reversal of PSNL-elicited tactile allodynia by local injection of the COX inhibitor ketorolac [Eur J Neurosci 15 (2002) 1037]."3.72Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury. ( Eisenach, JC; Ma, W, 2003)
") had no effect in two acute pain models, namely, the acetic acid-induced writhing (visceral pain) and the formalin test (tonic pain)."3.72Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. ( Jain, NK; Kulkarni, SK; Padi, SS; Singh, S, 2004)
" The parameters considered as prognostic factors were pain relief with ketorolac (K) or ketorolac plus opiate treatment (KO), and stone size (>or= or <6 mm)."3.71Comparison of stone size and response to analgesic treatment in predicting outcome of patients with renal colic. ( Prina, LD; Rancatore, E; Secic, M; Weber, RE, 2002)
"We investigated the antinociceptive properties of dexketoprofen trometamol [S(+)-ketoprofen tromethamine salt; SKP], a new analgesic, antiinflammatory drug, using the pain-induced functional impairment model in the rat (PIFIR), an animal model of arthritic pain."3.70Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid. ( Cabré, F; Díaz, I; Fernández-Guasti, A; López-Muñoz, FJ; Mauleón, D; Tost, D; Ventura, R, 1998)
"Caffeine potentiation of ketorolac-induced antinociception in the pain-induced functional impairment model in rats was assessed."3.70Effect of coadministration of caffeine and either adenosine agonists or cyclic nucleotides on ketorolac analgesia. ( Aguirre-Bañuelos, P; Castañeda-Hernández, G; Granados-Soto, V; López-Muñoz, FJ, 1999)
"To compare the clinical efficacy of single doses of intramuscular ketorolac and oral ibuprofen in the emergency department (ED) treatment of acute pain."3.69NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac. ( Price, SD; Watson, WA; Wright, JM, 1994)
"To report a case in which intravenous ketorolac was used successfully on a chronic basis to treat cancer pain."3.68Pain management with intravenous ketorolac. ( Kramer, MA; Miller, LJ, 1993)
"Ketorolac tromethamine was not superior to FM or PB in reducing lameness using a HBS model."2.94Ketorolac Is Not More Effective Than Flunixin Meglumine or Phenylbutazone in Reducing Foot Pain in Horses. ( Brunner, TJ; Cooper, BR; Davern, AJ; Grady, SE; Lescun, TB; Moore, GE; Taylor, SD, 2020)
" Adverse drug reactions may be renal, gastrointestinal, hematological, or immunologic."2.82Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years. ( Gorenflo, M; Saur, P; van den Anker, JN; van Dyk, M; Welzel, T; Ziesenitz, VC, 2022)
"Ketorolac or vehicle was instilled before the injection, and pain perception was recorded on a 0 to 100 Visual Analog Scale (VAS) immediately after the intravitreal administration."2.77Effect of ketorolac 0.5% drops on patients' pain perception during intravitreal injection procedure. ( Beredima, E; Georgakopoulos, CD; Makri, OE; Pharmakakis, NM; Vasilakis, PT, 2012)
"Pretreatment with parecoxib or ketorolac reduced the postinfusion area of pinprick hyperalgesia (P < 0."2.76Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans. ( Draegni, T; Heyerdahl, F; Lenz, H; Raeder, J; Schmelz, M; Stubhaug, A, 2011)
"Cutaneous allodynia and dysesthesia were then mapped and thermal and mechanical thresholds were measured."2.72The effect of intravenous ketorolac on capsaicin-induced deep tissue hyperalgesia. ( Kumar, K; Polston, GR; Wallace, MS, 2006)
"ketorolac (10mg q."2.71Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain. ( Busquets, C; Camba, MA; Castro, A; Contreras, D; Gálvez, R; Herrera, J; Rodríguez, MJ, 2003)
"Ketorolac tromethamine is a well-tolerated, effective medication in the treatment of acute biliary colic."2.70Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic. ( Henderson, SO; Newton, E; Swadron, S, 2002)
"Providing pain management for known opioid abusers is a challenging clinical task, in part because little is known about their pain experience and analgesic requirements."2.69Pain responses in methadone-maintained opioid abusers. ( Charuvastra, VC; Compton, P; Kintaudi, K; Ling, W, 2000)
"Ketorolac appears to be a safe and effective therapy for children when given in appropriate doses for a limited duration."2.67Clinical experience with ketorolac in children. ( Buck, ML, 1994)
" We found that gastrointestinal side effects were mainly reported with prolonged use, significant bleeding was reported in adenotonsillectomy, and adverse renal effects appeared to be limited to patients with specific coexisting risk factors."2.58Narrative review shows that the short-term use of ketorolac is safe and effective in the management of moderate-to-severe pain in children. ( Amoroso, S; Barbi, E; Calligaris, L; Marzuillo, P, 2018)
"Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID) with strong analgesic activity."2.40Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management. ( Brogden, RN; Gillis, JC, 1997)
"Ketorolac was not associated with increased risk of postoperative bleeding (0."1.72Predictors and Trends of Opioid-Sparing Radical Prostatectomy From a Large National Cohort. ( Bowman, A; Brant, A; Johnson, JP; Lewicki, P; Shoag, JE; Sze, C; Weinstein, IC, 2022)
"Ketorolac was associated with significantly longer closure times vs untreated control at both the 2."1.56Platelet Function: Meloxicam Intravenous in Whole Blood Samples From Healthy Volunteers. ( Du, W; Freyer, A; Hobson, S; Jahr, JS; Mack, R; McCallum, S; Minger, K; Searle, S, 2020)
" Both alone and in combination with ketorolac; S."1.46Synergistic antinociceptive interaction of Syzygium aromaticum or Rosmarinus officinalis coadministered with ketorolac in rats. ( Aguilar-Mariscal, H; Beltrán-Villalobos, KL; Déciga-Campos, M; González-Trujano, ME; López-Muñoz, FJ; Martínez-Salazar, MF; Ramírez-Cisneros, MLÁ; Rios, MY, 2017)
"When ibuprofen alone was administered, pain scores equal to or lower than 5/10 were associated with the greatest sensitivity and specificity for discharge."1.46Factors Associated With Discharge After Initial Emergency Treatment of Pediatric Migraine. ( Aravamuthan, BR; Mar, SS; Williams, KG, 2017)
" After F3 administration to rats, the Cmax (2."1.42Pharmacokinetics and analgesic effect of ketorolac floating delivery system. ( Abou El Ela, Ael S; El-Maraghy, DA; Hassan, MA; Radwan, MA, 2015)
"Population pharmacodynamic experiments sometime involve repeated measurements of ordinal random variables at specific time points."1.36Sample size/power calculations for repeated ordinal measurements in population pharmacodynamic experiments. ( Aarons, L; Ogungbenro, K, 2010)
" In a single dose study, its pharmacokinetic profile was compared with that of ketorolac."1.35Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations. ( Abignente, E; Boatto, G; Calignano, A; Curcio, A; Gavini, E; La Rana, G; Melisi, D; Nieddu, M; Rimoli, MG; Russo, R; Sasso, O, 2009)
" The MQS score accounted for variations in the types of analgesic medications, routes of administration, dosing schedules, and opioid dosing requirements."1.34Quantification of analgesic use in children with sickle cell disease. ( Beyer, JE; Jacob, E; Miaskowski, C; Savedra, M; Styles, L; Treadwell, M, 2007)
"Naloxone pretreatment had no effect on the antinociceptive effects of intradermal diclofenac, ketorolac, lysine acetyl salicylate, and sodium salicylate."1.34The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test. ( Deveci, MS; Dogrul, A; Gul, H; Gülmez, SE; Ossipov, MH; Porreca, F; Tulunay, FC, 2007)
"Pain is the most prominent feature of IC and current therapies provide limited relief."1.34Pharmacological validation of a model of cystitis pain in the mouse. ( Leventhal, L; Piesla, M; Wantuch, C, 2007)
"Ketorolac is a non-steroidal anti-inflammatory drug."1.34Ketorolac-dextran conjugates: synthesis, in vitro and in vivo evaluation. ( Chaturvedi, SC; Trivedi, P; Vyas, S, 2007)
"Bone cancer pain is mostly associated with an inflammatory response dominated by local activation of osteoclasts and by astrogliosis in the spinal cord."1.33The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception. ( Beitz, A; Eikmeier, L; Fike, JR; Jasmin, L; Ohara, PT; Tien, DA; Vit, JP; Wilcox, GL, 2006)
", its pharmacokinetic (PK) properties] and how these PK properties differ between individuals in a population (i."1.32An evaluation of population D-optimal designs via pharmacokinetic simulations. ( Dodds, MG; Foracchia, M; Hooker, AC; Vicini, P, 2003)
"Life-threatening acute respiratory distress syndrome (ARDS) complicates the recovery of patients with burn and inhalation injury."1.32Ketorolac may control more than pain. ( Isik, F, 2003)
" Rats were anesthetized, then the electromyographic response in the rectus abdominus muscle and mean arterial blood pressure change to UCD was recorded before and with cumulative dosing of intravenous or intrathecal ketorolac."1.32Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats. ( Eisenach, JC; Sandner-Kiesling, A; Shin, SW, 2003)
"Ketorolac is a powerful potentiator of morphine antinociception during visceral nociception in the rat."1.29Ketorolac potentiates morphine antinociception during visceral nociception in the rat. ( Gebhart, GF; Maves, TJ; Meller, ST; Pechman, PS, 1994)
"The gene for sickle cell disease is carried by 8% of the African-American population in the United States."1.28Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department. ( Pollack, CV; Sanders, DY; Severance, HW, 1992)

Research

Studies (159)

TimeframeStudies, this research(%)All Research%
pre-19902 (1.26)18.7374
1990's47 (29.56)18.2507
2000's46 (28.93)29.6817
2010's43 (27.04)24.3611
2020's21 (13.21)2.80

Authors

AuthorsStudies
Muchowski, JM1
Unger, SH1
Ackrell, J1
Cheung, P1
Cooper, GF1
Cook, J2
Gallegra, P1
Halpern, O1
Koehler, R1
Kluge, AF1
Curcio, A1
Sasso, O1
Melisi, D1
Nieddu, M1
La Rana, G1
Russo, R1
Gavini, E1
Boatto, G1
Abignente, E1
Calignano, A1
Rimoli, MG1
Chae, E1
Yi, H1
Choi, Y1
Cho, H1
Lee, K1
Moon, H1
Tsze, DS1
Lubell, TR1
Carter, RC1
Chernick, LS1
DePeter, KC1
McLaren, SH1
Kwok, MY1
Roskind, CG1
Gonzalez, AE1
Fan, W1
Babineau, SE1
Friedman, BW1
Dayan, PS1
Donnenfeld, ED1
Mychajlyszyn, D1
Mychajlyszyn, A1
Stein, R1
Martínez-Martínez, MDC1
Parra-Flores, LI1
Baeza-Flores, GDC1
Torres-López, JE2
Nurathirah, MN1
Yazid, MB1
Norhayati, MN1
Baharuddin, KA1
Abu Bakar, MA1
Razi, A1
Farrokhi, E1
Lotfabadi, P1
Hosseini, SS1
Saadati, H1
Haghighi, R1
Rameshrad, M1
Visco, DM2
Brant, A1
Lewicki, P1
Johnson, JP1
Weinstein, IC1
Bowman, A1
Sze, C1
Shoag, JE1
Suwannaphisit, S1
Suwanno, P1
Fongsri, W1
Chuaychoosakoon, C1
Ziesenitz, VC1
Welzel, T1
van Dyk, M1
Saur, P1
Gorenflo, M1
van den Anker, JN1
Modi, J1
Magee, T1
Rucker, B1
Flores, H1
Wise, A1
Kee, M1
Garrett, M1
Roberts, W1
Vassar, M1
Elnaghy, AM3
Elshazli, AH3
Elsaka, SE3
Hegde, V1
Shanmugasundaram, S1
Shaikh, S1
Kulkarni, V1
Suresh, N1
Setzer, FC1
Nagendrababu, V1
Murdoch, I1
Carver, AL1
Sultan, P1
O'Carroll, JE1
Blake, L1
Carvalho, B1
Onwochei, DN1
Desai, N1
Schubert, AK1
Seneviratne, V1
Stolz, J1
Wiesmann, T1
Wulf, H1
Eberhart, L1
Dinges, HC1
Prescott, MG1
Iakovleva, E1
Simpson, MR1
Pedersen, SA1
Munblit, D1
Vallersnes, OM1
Austad, B1
Miranda, HF1
Noriega, V1
Sierralta, F1
Poblete, P1
Aranda, N1
Prieto, JC1
Jahr, JS1
Searle, S1
McCallum, S1
Mack, R1
Minger, K1
Freyer, A1
Du, W2
Hobson, S1
Galvis, V1
Tello, A1
Alfonso, MA1
Carreño, NI1
Berrospi, RD1
Niño, CA1
Bedi, R1
Grady, SE1
Lescun, TB1
Moore, GE1
Cooper, BR1
Davern, AJ1
Brunner, TJ1
Taylor, SD1
Riley, B1
Kawai, K1
Irace, AL1
Leung, P1
Adil, E1
Torre, G1
Avvedimento, S1
Guastafierro, A1
Faenza, M1
Pieretti, G1
Cuomo, R1
Izzo, S1
Ciccarelli, F1
Vadivelu, N1
Chang, D1
Helander, EM1
Bordelon, GJ1
Kai, A1
Kaye, AD1
Hsu, D1
Bang, D1
Julka, I1
Beltrán-Villalobos, KL1
Déciga-Campos, M1
Aguilar-Mariscal, H1
González-Trujano, ME2
Martínez-Salazar, MF1
Ramírez-Cisneros, MLÁ1
Rios, MY1
López-Muñoz, FJ5
Kao, CW1
Lee, D1
Wu, MH1
Chen, JK1
He, HL1
Liu, SJ1
El-Feky, GS1
Farouk Abdulmaguid, R1
Zayed, GM1
Kamel, R1
Marzuillo, P1
Calligaris, L1
Amoroso, S1
Barbi, E1
Tsiklauri, N3
Pirkulashvili, N1
Nozadze, I3
Nebieridze, M2
Gurtskaia, G3
Abzianidze, E2
Tsagareli, MG3
Leow, MQH1
Hay, ASR1
Ng, SL1
Choudhury, MM1
Li, H1
McGrouther, DA1
Tay, SC1
Wu, PC1
Shieh, DB1
Hsiao, HT2
Wang, JC1
Lin, YC1
Liu, YC1
Matava, MJ1
Maleki Verki, M1
Porozan, S1
Motamed, H1
Fahimi, MA1
Aryan, A1
Moerke, MJ1
Li, G1
Golani, LK1
Negus, SS3
Hashem, A1
Ghobrial, FK1
Elbaset, MA1
Atwa, AM1
Fadallah, M1
Laymon, M1
El-Assmy, A1
Sheir, KZ1
Abol-Enein, H1
Van Hulle Vincent, C2
Wilkie, DJ2
Wang, E2
Hirsch, S1
Corradini, L1
Just, S1
Arndt, K1
Doods, H1
Gratieri, T1
Pujol-Bello, E1
Gelfuso, GM1
de Souza, JG1
Lopez, RF1
Kalia, YN1
Radwan, MA1
Abou El Ela, Ael S1
Hassan, MA1
El-Maraghy, DA1
Walker, NA1
Bultitude, MF1
Brislane, K1
Thomas, K1
Glass, JM1
Buccelletti, F2
Marsiliani, D2
Zuccalà, G1
Iacomini, P1
Proietti, L1
Pola, E1
Zirio, G1
Genitiempo, M1
Marrocco, R1
Conti, C1
Brunetti, C1
Rocchi, L1
Merendi, G1
D'Aurizio, G1
Gilardi, E2
Franceschi, F2
Kim, JH1
Park, SY1
Kim, MG1
Choi, H1
Song, D1
Cho, SW1
Song, YS1
Ngo, LL1
Ward, KK1
Mody, SK1
Aravamuthan, BR1
Mar, SS1
Williams, KG1
Chamie, K1
Chi, A1
Hu, B1
Keegan, KA1
Kurzrock, EA1
Chaou, CH1
Chen, CK1
Chen, JC1
Chiu, TF1
Lin, CC1
Cansino, C1
Edelman, A1
Burke, A1
Jamshidi, R1
Ogungbenro, K1
Aarons, L1
Chung, SY1
Krambeck, AE1
Walsh, RS1
Denstedt, JD1
Preminger, GM1
Li, J1
Evans, JC1
Lingeman, JE1
Eisenach, JC4
Curry, R1
Tong, C1
Houle, TT1
Yaksh, TL1
Carroccia, A1
Giupponi, B1
De Marco, G1
Merra, G1
Mancini, F1
Potenza, A1
Giannuzzi, R1
Calcinaro, S1
Marini, M1
Gentiloni Silveri, N1
Hamza, M1
Wang, XM1
Wu, T1
Brahim, JS1
Rowan, JS1
Dionne, RA1
Joshi, HB1
Keeley, FX1
Timoney, AG1
Rhiu, S1
Chung, SA1
Kim, WK1
Chang, JH1
Bae, SJ1
Lee, JB1
Martínez, AL1
Chávez, M1
Pellicer, F1
Moreno, J1
Lenz, H1
Raeder, J1
Draegni, T1
Heyerdahl, F1
Schmelz, M1
Stubhaug, A1
Cormio, L2
Lorusso, F2
Selvaggio, O2
Perrone, A2
Sanguedolce, F2
Pagliarulo, V2
Bufo, P2
Carrieri, G2
Voepel-Lewis, T1
Ing Lorenzini, K1
Besson, M1
Daali, Y1
Salomon, D1
Dayer, P1
Desmeules, J1
Garnock-Jones, KP1
Georgakopoulos, CD1
Vasilakis, PT1
Makri, OE1
Beredima, E1
Pharmakakis, NM1
Schiavenato, M1
von Baeyer, CL1
Craig, KD1
Prina, LD1
Rancatore, E1
Secic, M1
Weber, RE1
Huang, YW2
Buerkle, H1
Lee, TH1
Lu, CY2
Lin, CR1
Lin, SH2
Chou, AK1
Muhammad, R1
Yang, LC2
Henderson, SO1
Swadron, S1
Newton, E1
Ma, W2
Weaver, CS1
Terrell, KM1
Hooker, AC1
Foracchia, M1
Dodds, MG1
Vicini, P1
Jacob, E2
Miaskowski, C2
Savedra, M2
Beyer, JE2
Treadwell, M2
Styles, L2
Benedetti, F1
Pollo, A1
Lopiano, L1
Lanotte, M1
Vighetti, S1
Rainero, I1
Rodríguez, MJ1
Contreras, D1
Gálvez, R1
Castro, A1
Camba, MA1
Busquets, C1
Herrera, J1
Isik, F1
Shin, SW1
Sandner-Kiesling, A1
Compton, P2
Charuvastra, VC2
Ling, W2
Brousseau, DC1
Duffy, SJ1
Anderson, AC1
Linakis, JG1
Padi, SS1
Jain, NK1
Singh, S1
Kulkarni, SK1
Hsueh, SF1
Chao, CS1
Tan, PH1
Hsieh, SW1
Chung, NC1
Huang, PL1
Lyu, PC1
Harris, SI1
Stoltz, RR1
LeComte, D1
Hubbard, RC1
Puntillo, K1
Ley, SJ1
Mireku-Boateng, AO1
de Franceschi, L1
Finco, G1
Vassanelli, A1
Zaia, B1
Ischia, S1
Corrocher, R1
Hatch, RL1
Good, P1
Tullio, F1
Jackson, K1
Goodchild, C1
Ashby, M1
Bledsoe, B1
Braude, D1
Dailey, MW1
Myers, J1
Richards, M1
Wesley, K1
Vit, JP1
Ohara, PT1
Tien, DA1
Fike, JR1
Eikmeier, L1
Beitz, A1
Wilcox, GL1
Jasmin, L1
Kumar, K1
Polston, GR1
Wallace, MS1
Esgin, H1
Samut, HS1
Dogrul, A1
Gülmez, SE1
Deveci, MS1
Gul, H1
Ossipov, MH1
Porreca, F1
Tulunay, FC1
Arora, S1
Wagner, JG1
Herbert, M1
Wantuch, C1
Piesla, M1
Leventhal, L1
Ahmed, A1
Abbasi, S1
Prakash, C1
Chandar, S1
Vyas, S1
Trivedi, P1
Chaturvedi, SC1
Lee, IO1
Seo, Y1
Eipe, N1
Kay, J1
Rooks, WH1
Tomolonis, AJ1
Maloney, PJ1
Wallach, MB1
Schuler, ME1
Reuben, SS1
Steinberg, RB1
Kreitzer, JM1
Duprat, KM1
Turturro, MA1
Paris, PM1
Seaberg, DC1
Butelman, ER1
Gatch, MB1
Woods, JH1
Turner, DM1
Warson, JS1
Wirt, TC1
Scalley, RD1
Cochran, RS1
Miller, KJ1
Bradford, TH1
Robertson, K1
Norman, PF1
Meeks, GR1
Eriksson, M1
Buck, ML1
Leeson-Payne, CG1
Nicoll, JM1
Hobbs, GJ1
Maves, TJ1
Pechman, PS1
Meller, ST1
Gebhart, GF1
Thrush, DN1
Steighner, ML1
Wright, JM1
Price, SD1
Watson, WA1
Richardson, P1
Steingart, R1
Uphouse, LA1
Welch, SP1
Ward, CR1
Ellis, EF1
Embrey, JP1
Blackwell, N2
Bangham, L2
Hughes, M2
Melzack, D2
Trotman, I2
Silverman, DG1
O'Connor, TZ1
Brull, SJ1
Granados-Soto, V3
Flores-Murrieta, FJ1
Castañeda-Hernández, G2
Hong, E1
Miller, LJ1
Kramer, MA1
Code, W1
Hubbell, K1
Puntillo, KA1
Smith, AJ1
Power, I1
Gillis, JC1
Brogden, RN1
Dexter, TJ1
Singh, H1
Bossard, RF1
White, PF1
Yeatts, RW1
Todd, KH1
Ventura, R1
Díaz, I1
Fernández-Guasti, A1
Tost, D1
Cabré, F1
Mauleón, D1
Hall, SR1
Milne, B1
Loomis, C1
McArdle, P1
Lilley, LL1
Guanci, R1
Hardwick, WE1
Givens, TG1
Monroe, KW1
King, WD1
Lawley, D1
Aguirre-Bañuelos, P1
Matambo, J1
Moodley, J1
Chigumadzi, P1
Yull, DN1
Barkshire, KF1
Dexter, T1
Kintaudi, K1
Jelinek, GA1
Rainer, TH1
Jacobs, P1
Ng, YC1
Cheung, NK1
Tam, M1
Lam, PK1
Wong, R1
Cocks, RA1
Brandt, MR1
Furness, MS1
Mello, NK1
Rice, KC1
Long, TD1
Twillman, RK1
Cathers-Schiffman, TA1
O'Donnell, T1
Lázaro-Ibáñez, GG1
Sanders, DY1
Severance, HW1
Pollack, CV1
Wright, SW1
Norris, RL1
Mitchell, TR1
Yealy, DM1
Weeks, DB1
Goodman, E1
Vanos, DN1
Ramamurthy, S1
Hoffman, J1
Freie, HM1
Baumann, TJ1

Clinical Trials (29)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Nasal Migraine Cocktail Used In Pediatric Emergency Department: A Clinical Trial[NCT06083571]Phase 2120 participants (Anticipated)Interventional2024-01-01Not yet recruiting
Evaluation of Perioperative Usage of Ketorolac on Postoperative Pain Reduction in Pediatric Patients With Adenotonsillectom[NCT05074056]Phase 4200 participants (Anticipated)Interventional2022-02-08Recruiting
Effectiveness of the Distraction Methods on Pain, Anxiety and Satisfaction During Cystoscopy[NCT02764294]120 participants (Actual)Interventional2016-03-31Completed
Intravenous Ketorolac Administration to Attenuate Post-procedural Pain Associated With Intrauterine Device Placement: A Randomized, Double-Blind, Placebo-Controlled Trial[NCT05875571]Phase 418 participants (Anticipated)Interventional2023-09-30Not yet recruiting
Pain Control for Intrauterine Device Placement: A Randomized, Double Blind Control Trial of Ketorolac Prior to Intrauterine Device Placement.[NCT01664559]67 participants (Actual)Interventional2012-07-31Completed
Multi-dose Ibuprofen Prophylaxis for IUD-insertion (MIPI): A Triple Blinded[NCT03868137]86 participants (Anticipated)Interventional2020-09-28Recruiting
Does LI4 Acupuncture Provide an Effective Analgesia During Intrauterine Device[NCT04963582]72 participants (Actual)Interventional2021-07-05Completed
Oxybutynin for Post-surgical Bladder Pain and Urgency[NCT03952299]Phase 3100 participants (Anticipated)Interventional2021-09-01Recruiting
Paracervical Block for Pain Control During Osmotic Dilator Placement: a Randomized Controlled Trial[NCT02354092]14 participants (Actual)Interventional2015-04-02Terminated
Paracervical Block With Ketorolac and Lidocaine in First Trimester Surgical Abortions[NCT00617097]Phase 2/Phase 350 participants (Actual)Interventional2008-01-31Completed
A Prospective, Randomized, Pilot Study of Preoperative Anti-Inflammatory Therapy for Ureteral Stent Symptoms[NCT03638999]Early Phase 136 participants (Anticipated)Interventional2018-07-31Recruiting
Can Opioid-induced Hyperalgesia be Prevented by Gradual Dose Reduction vs. Abrupt Withdrawal of Remifentanil?[NCT01702389]Phase 416 participants (Actual)Interventional2012-10-31Completed
Prospective, Randomized, Allocation-Concealed, Blinded Study Designed to Compare Ketorolac Sublingual and Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children[NCT02653742]Phase 4150 participants (Anticipated)Interventional2015-05-31Recruiting
The Evaluation of the Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol.[NCT01342510]Phase 4200 participants (Actual)Interventional2011-04-30Completed
Assessment of the Analgesic Efficacy of Intravenous Ibuprofen in Biliary Colic[NCT02268955]22 participants (Actual)Interventional2014-09-09Completed
Placebo Effect in Children With Attention Deficit Disorder and/or Hyperactivity Disorder[NCT04766580]44 participants (Anticipated)Interventional2021-02-17Recruiting
Intranasal Lidocaine to Treat Pediatric Migraine in the Emergency Department[NCT03576820]Phase 350 participants (Anticipated)Interventional2018-10-15Recruiting
A Randomized Double Blinded Study Comparing Use of Prochlorperazine Versus Prochlorperazine and Ketorolac in the Treatment of Pediatric Migraine in the Emergency Department[NCT01534806]Phase 40 participants (Actual)Interventional2012-01-31Withdrawn (stopped due to Drug is backordered;)
Effect of Intravenous Dynastat on Postoperative Sore Throat: A Randomized Double-blinded Controlled Trial[NCT03915561]Phase 2140 participants (Anticipated)Interventional2019-03-01Recruiting
Acute Kidney Injury and Nonsteroidal Anti-inflammatory Drugs in Patients Undergoing High-risk Abdominal or Thoracic Surgery[NCT02553174]50 participants (Actual)Observational2016-06-01Terminated (stopped due to unable to recruit sufficient patients to satisfy study protocols)
A Randomized Double-blinded Trial Comparing the Clinical Efficacy and Pharmacokinetic Parameters of Oral Diclofenac and Intramuscular Diclofenac in Patients With Acute Limb Injuries[NCT03472339]Phase 4300 participants (Anticipated)Interventional2018-01-15Recruiting
Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia[NCT02024568]Phase 238 participants (Anticipated)Interventional2013-12-31Not yet recruiting
Preliminary Studies for Whole Genome Association Study (WGAS) in Acute Perioperative Pain[NCT01557751]156 participants (Actual)Interventional2010-02-28Completed
A Prospective Randomized Double-blind Placebo Controlled Trial; Does Pre and Postoperative Dextromethorphan Reduce Post-tonsillectomy Pain in Children?[NCT02727491]Phase 485 participants (Actual)Interventional2012-03-31Completed
A Randomized Controlled Trial of IV Ketorolac to Prevent Post-ERCP Pancreatitis[NCT02465138]Phase 40 participants (Actual)Interventional2023-11-30Withdrawn (stopped due to Lack of Funding)
Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans[NCT01222091]Phase 210 participants (Actual)Interventional2009-02-28Completed
The Effects of Opioid Taper on Opioid-Induced Hyperalgesia[NCT03063905]15 participants (Actual)Observational2017-01-31Terminated (stopped due to funding expired)
Evaluation of the Effects of Ketorolac 15mg IV Versus 30mg IV on Duration of Analgesia in Patients Who Present to the Emergency Department With Renal Colic[NCT05776953]Phase 4200 participants (Anticipated)Interventional2023-12-21Recruiting
A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis[NCT00094887]Phase 2150 participants (Actual)Interventional2004-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

VAS (Visual Analogue Scale) Measurement of Pain

The patient marked their pain on a 0 to 10cm visual analogue scale, where 0 cm is no pain and 10 cm is the worst pain ever. (NCT01664559)
Timeframe: Pain with IUD placement, measured immediately after placement

Interventionunits on a scale (Median)
Placebo With 1cc Normal Saline IM5.2
Toradol, 30mg in 1cc IM3.6

Nulliparous Patients - Subgroup Analysis

"The patient marked their pain on a 0 to 10cm visual analogue scale, where 0 cm is no pain and 10 cm is the worst pain ever.~Prior to injection of study drug, anticipated pain~Pain from study drug injection, measured immediately after injection~Pain from speculum insertion, measured immediately after insertion~Pain with tenaculum placement, measured immediately after placement~Pain with uterine sounding, measured immediately after removal of the sound~Pain at 5 minutes after placement of the intrauterine device~Pain at 15 minutes after placement of the intrauterine device" (NCT01664559)
Timeframe: immediately after each step (see description)

,
Interventioncm (Median)
1) Anticipated pain2) Pain with injection3) Speculum insertion4) Tenaculum placement5) Uterine sounding6) Pain with IUD placement7) 5 min after placement8) 15 min after placement
Placebo With 1cc Normal Saline IM2.81.82.36.38.48.13.74.8
Toradol, 30mg in 1cc IM3.61.21.54.36.05.42.71.8

Pain Scores at Other Time Points During and After IUD Placement

"The patient marked their pain on a 0 to 10cm visual analogue scale, where 0 cm is no pain and 10 cm is the worst pain ever.~Prior to injection of study drug, anticipated pain~Pain from study drug injection, measured immediately after injection~Pain from speculum insertion, measured immediately after insertion~Pain with tenaculum placement, measured immediately after placement~Pain with uterine sounding, measured immediately after removal of the sound~Pain at 5 minutes after placement of the intrauterine device~Pain at 15 minutes after placement of the intrauterine device" (NCT01664559)
Timeframe: immediately after each step (see description)

,
Interventioncm (Median)
Anticipated painPain with injectionSpeculum insertionTenaculum placementUterine sounding5 min after procedure15 min after procedure
Placebo With 1cc Normal Saline IM4.41.02.63.95.02.21.6
Toradol, 30mg in 1cc IM3.50.61.52.54.30.30.1

Post-insertion Patient Questionnaire

"Questions assessed in multiple choice format:~Side effects~injection site pain~overall satisfaction with IUD insertion experience~would they still recommend IUD placement to a friend?~significant pain for which they desired acetaminophen prior to leaving the office?" (NCT01664559)
Timeframe: assessed at 15 minutes after IUD insertion

,
Interventionparticipants (Number)
Reported side effectsInjection site pain - just as bad/worse than IUDSatisfied or very satisfied with overall IUD procRecommend IUD to a friendDesires additional pain medication
Placebo With 1cc Normal Saline IM128302816
Toradol, 30mg in 1cc IM8631306

Post-insertion Provider Questionnaire

"The provider will be asked to fill out a multiple choice format questionnaire:~what level training are you?~which IUD was inserted?~what was the purpose of IUD placement?~what was the position of the uterus?~did the IUD placement process require cervical dilation?~were you able to complete the IUD insertion?~was there bleeding from the cervix that required more than 5 min to control?~were there any major complications with the IUD insertion?~did the patient take tylenol prior to leaving the office?" (NCT01664559)
Timeframe: Immediately after IUD placement, on average within 1 hour

,
Interventionparticipants (Number)
Level of training - PGY1Level of training - PGY2Level of training - PGY3Level of training - PGY4Level of training - AttendingIUD type - levonogestrelIUD type - copperPurpose of IUD - contraceptionPurpose of IUD - AUBPosition of uterus - antevertedPosition of uterus - retrovertedPosition of uterus - midpositionedCervical dilation neededAble to complete the IUD placementSignificant bleedingMajor complicationsTook acetaminophen prior to leaving the office
Placebo With 1cc Normal Saline IM22351221233119692340017
Toradol, 30mg in 1cc IM5136632823212058233207

Pain at Time of Osmotic Dilator Placement

"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) recorded at time immediately after osmotic dilator placement. 0 mm=No Pain and 100 mm= worst possible pain. A higher score indicates a higher level of pain." (NCT02354092)
Timeframe: Within 5 minutes of PCB or sham procedure

Interventionunits on a scale (Mean)
Sham Group46
Paracervical Block Group32

Pain With Overall Dilator Placement

"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) recorded 15 minutes after osmotic dilator placement. mm=No Pain and 100 mm= worst possible pain. A higher mean score indicates a higher level of pain experienced at this time point." (NCT02354092)
Timeframe: 15 minutes after dilator placement

Interventionunits on a scale (Mean)
Sham Group42
Paracervical Block Group35

Pain With Paracervical Block or Sham

"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) recorded at time immediately after last injection for paracervical block OR script for sham injection. 0 mm=No Pain and 100 mm= worst possible pain. A higher score indicates a higher level of pain." (NCT02354092)
Timeframe: Within 5 minutes after baseline

Interventionunits on a scale (Mean)
Sham Group19
Paracervical Block Group39

Reported Pain at Baseline

"Measure of distance (mm) from the left (no pain) on the 100-mm visual analog scale (VAS - reflecting magnitude of pain) of pain recorded at baseline prior to the paracervical block or sham block procedure. 0 mm=No Pain and 100 mm= worst possible pain. A higher score indicates a higher level of pain." (NCT02354092)
Timeframe: Baseline, just prior to PCB or sham procedure

Interventionunits on a scale (Mean)
Sham Group4
Paracervical Block Group19

Reported Symptoms

fever, chills, vomiting, heavy bleeding/clots (collected without regard to the specific event) (NCT00617097)
Timeframe: end of study (upon discharge from facility after procedure)

Interventionparticipants (Number)
Paracervical Block With Lidocaine3
Paracervical Block With Ketorolac and Lidocaine0

Visual Analogue Scale Regarding Satisfaction Level

100-mm Visual Analogue Scale -- minimum: 0 mm (lower satisfaction), maximum: 100 mm (greater satisfaction) (NCT00617097)
Timeframe: end of study (prior to clinic discharge)

Interventionmm (Mean)
Paracervical Block With Lidocaine62.9
Paracervical Block With Ketorolac and Lidocaine63.6

Complications

(NCT00617097)
Timeframe: end of study

,
Interventionparticipants (Number)
minorserious
Paracervical Block With Ketorolac and Lidocaine12
Paracervical Block With Lidocaine10

Level of Pain During Specific Time Intervals Throughout D&C Procedure.

"100-mm Visual Analogue Scale (VAS) during specific time intervals of D&C procedure: minimum: 0 mm (less pain); maximum: 100 mm (more pain)~Time intervals include: basline expected level of pain during procedure, after speculum insertion, at paracervical block injection, after dilation, end of procedure, and 30 minutes after procedure." (NCT00617097)
Timeframe: Baseline, Speculum Insertion, at Paracervical block injection, After dilation, End of procedure, 30 minutes after procedure

,
Interventionmm (Mean)
expected level of pain during procedureafter speculum insertionduring paracervical block administrationafter cervical dilationimmediately after procedure30 min after procedure
Paracervical Block With Ketorolac and Lidocaine51.732.746.059.864.317.6
Paracervical Block With Lidocaine52.233.650.874.861.521.8

Number of Patients With Pain Associated With Injection of Propofol.

"Ten seconds following injection of propofol, subjects were asked Are you having pain at your IV site? Any behavioral signs were noted. Injection pain was assessed using the following four point scale: 0 = no pain; 1 = mild pain (pain reported only in response to questioning and without behavioral signs); 2 = moderate pain (pain reported in response to questioning and accompanied by a behavioral sign, or pain reported spontaneously without questioning); and 3 = severe pain (strong vocal response or response accompanied by facial grimacing, arm withdrawal, or tears)." (NCT01342510)
Timeframe: < 1 minute.

Interventionparticipants reporting pain (Number)
Lidocaine11
Magnesium25
Lidocaine/Magnesium15
Control18

Percentage of Participants Reporting Pain With Injection of Propofol

Following injection of the study drug, 50 mg of propofol will be injected. Ten seconds after propofol, subjects will be asked a standard question about pain. Behavioral signs will be noted. Pain will be assessed using a four point scale: 0=no pain, 1=mild pain (pain reported only in response to questioning and without behavioral signs), 2=moderate pain (pain reported in response to questioning and a behavioral sign, or pain reported without questioning), 3=severe pain (strong vocal response or behavioral response). (NCT01342510)
Timeframe: Approximately 10 seconds following administration of propofol.

Interventionpercentage of patients reporting pain (Number)
Lidocaine29
Magnesium57
Lidocaine/Magnesium41
Control46

Pain Score 120 Minutes After Study Medication Administration

Pain is measured on a visual analog scale 0=no pain and 10=worst pain imaginable. (NCT02268955)
Timeframe: 120 minutes post medication administration

Interventionscore on a scale (Median)
Control Group: Adults Age 18-55 Years3.0
IV Ibuprofen: Adults Age 18-55 Years0.3

NRS-Pain With Movement on POD 2

"The primary endpoint is the pain reported by subjects, using the NRS-Pain with movement on the second day after surgery.The assumption behind this study is that certain genetic variants (e.g. single-nucleotide polymorphism (SNP) are responsible for part of total variation of certain clinical phenotypes (e.g. post-operative pain here).~Numeric Rating Score Pain Assessment (0-10 scale where 0 indicates no pain at all and 10 indicates the worst pain imaginable) on Post Op Day 2, Pain with Movement" (NCT01557751)
Timeframe: Postoperative day (POD) 2

Interventionunits on a scale (Mean)
Total Knee Arthroplasty Subjects Who Are Genotyped2.83

Objective Opioid Withdrawal Scale (OOWS)

OOWS: Is a 13-item instrument of documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score = 13, minimum score = 0. Lower scores correspond to fewer symptoms. (NCT01222091)
Timeframe: Pretreatment [90 min prior to 60-min REM infusion]; 30 min prior to 60-min REM infusion; 15 and 40 min after start of 60-min REM infusion; 5, 15, and 75 minutes after finish of 60-min REM infusion)

,
Interventionunits on a scale (Mean)
Pretreatment30 min prior to REM infusion15 min after start of REM infusion40 min after start of REM infusion5 minutes after finish of REM infusion15 minutes after finish of REM infusion75 minutes after finish of REM infusion
Placebo1.11.10.80.51.82.11.6
Propranolol1.21.10.10.832.81.7

Percent Change From Baseline in Size (Area) of Secondary Hyperalgesia After Cessation of Remifentanil Infusion, a Measure of Opioid-induced Hyperalgesia (OIH).

A slightly modified version of a previously described model of secondary hyperalgesia was used. Two copper wires contained in a microdialysis catheter were inserted in parallel over a length of 5 mm into the dermis of the right volar forearm. The wires were connected to a constant current stimulator controlled by a pulse generator to deliver rectangular and monophasic pulses with a duration of 0.5 mg at 2 Hz. Over a period of 15 min, the current was increased by targeting a pain rating of 5 on an 11-point numeric rating scale (0 = no pain and 10 = maximum tolerable pain) until the hyperalgesic area surrounding the stimulation site was fully established. Once the area was established, the current was held constant. Percent change from baseline in size (area) of secondary hyperalgesia after cessation of remifentanil infusion was calculated per group. (NCT01222091)
Timeframe: Baseline; 15 min post remifentanil (REM) infusion; 60 min post REM infusion

,
Interventionpercentage of change (Number)
15 min post remifentanil infusion60 min post remifentanil infusion
Placebo-34141.5
Propranolol-28-19

Length of Hospitalization

Length of hospitalization is defined as the length of time from admission to discharge order (NCT00094887)
Timeframe: within 40 days

InterventionDays (Median)
Inhaled Nitric Oxide4.06
Placebo3.11

Number of Participants Discharged to Home Within the First 24 Hours

(NCT00094887)
Timeframe: within 24 hours

InterventionParticipants (Count of Participants)
Inhaled Nitric Oxide5
Placebo7

Number of Participants With Acute Chest Syndrome/Pneumonia Requiring Blood Transfusion

Number of participants who required a blood transfusion before discharge because of acute chest syndrome/pneumonia (NCT00094887)
Timeframe: within 40 days

InterventionParticipants (Count of Participants)
Inhaled Nitric Oxide8
Placebo7

Time to Vaso-occlusive Pain Crisis (VOC) Resolution

"VOC resolution was defined by all of the following conditions:~Pain relief - Visual Analog Scale (VAS) pain scores of 6 or less, (6 as worst and 0 as best)~Freedom from parenteral narcotic use,~Ability to walk unless the subject was not able to walk for any reason other than acute VOC prior to the onset of crisis,~Subject and/or family's belief that the painful crisis could be managed at home with or without oral analgesic use, and the physician concurred with that assessment." (NCT00094887)
Timeframe: within 30 days

InterventionHours (Median)
Inhaled Nitric Oxide61.83
Placebo55.16

Number of Participants Readmitted to Hospital Within 30 Days After Discharge

The number of participants readmitted to the hospital for any reason within 30 days after discharge (NCT00094887)
Timeframe: during first 24 hours and during 30 day follow-up

,
InterventionParticipants (Count of Participants)
during first 24 hoursduring 30-day follow-up
Inhaled Nitric Oxide09
Placebo017

Total Dose of Opioids Received

The total dose (mg) of opioid medications received during the trial (NCT00094887)
Timeframe: within 8 hours and within 40 days

,
Interventionmg (Median)
within 8 hourswithin 40 days
Inhaled Nitric Oxide16.25153.75
Placebo17.25211.37

Reviews

13 reviews available for ketorolac and Ache

ArticleYear
Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2022, Volume: 29, Issue:9

    Topics: Caffeine; Dexamethasone; Diclofenac; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Pain; Ph

2022
Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.
    Paediatric drugs, 2022, Volume: 24, Issue:6

    Topics: Adolescent; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; C

2022
Comparison of different nonsteroidal anti-inflammatory drugs for cesarean section: a systematic review and network meta-analysis.
    Korean journal of anesthesiology, 2023, Volume: 76, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cesarean Section; Diclofenac; Female; Humans; In

2023
The effect of adjuvants added to local anaesthetics for single-injection upper extremity peripheral regional anaesthesia: A systematic review with network meta-analysis of randomised trials.
    European journal of anaesthesiology, 2023, 09-01, Volume: 40, Issue:9

    Topics: Anesthesia, Conduction; Anesthetics, Local; Dexamethasone; Dexmedetomidine; Humans; Ketorolac; Midaz

2023
Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis.
    BMC pediatrics, 2023, 08-18, Volume: 23, Issue:1

    Topics: Analgesia; Child; Fentanyl; Humans; Ketamine; Ketorolac; Pain

2023
Ketorolac, Oxymorphone, Tapentadol, and Tramadol: A Comprehensive Review.
    Anesthesiology clinics, 2017, Volume: 35, Issue:2

    Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Oxymorphone; Pain; P

2017
Narrative review shows that the short-term use of ketorolac is safe and effective in the management of moderate-to-severe pain in children.
    Acta paediatrica (Oslo, Norway : 1992), 2018, Volume: 107, Issue:4

    Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Humans; Infant; Ketor

2018
Injectable Nonsteroidal Anti-Inflammatory Drugs in Sport.
    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine, 2018, Volume: 28, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Athletes; Athletic Injuries; Humans; Inflammation; Injectio

2018
Intranasal ketorolac: for short-term pain management.
    Clinical drug investigation, 2012, Jun-01, Volume: 32, Issue:6

    Topics: Administration, Intranasal; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as

2012
Evidence-based emergency medicine. Update: do ophthalmic nonsteroidal anti-inflammatory drugs reduce the pain associated with simple corneal abrasion without delaying healing?
    Annals of emergency medicine, 2003, Volume: 41, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Age

2003
Myth: parenteral ketorolac provides more effective analgesia than oral ibuprofen.
    CJEM, 2007, Volume: 9, Issue:1

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Emergency Service, Hospital; Humans;

2007
Ketorolac. A reappraisal of its pharmacodynamic and pharmacokinetic properties and therapeutic use in pain management.
    Drugs, 1997, Volume: 53, Issue:1

    Topics: Analgesics, Non-Narcotic; Humans; Ketorolac; Pain; Tolmetin

1997
Intravenous analgesia.
    Critical care clinics, 1999, Volume: 15, Issue:1

    Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Critical Care; Humans; Inje

1999

Trials

50 trials available for ketorolac and Ache

ArticleYear
Intranasal ketorolac versus intravenous ketorolac for treatment of migraine headaches in children: A randomized clinical trial.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2022, Volume: 29, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Double-Blind Method; Humans; Ketorolac; Migraine Dis

2022
Pain control and reduction of opioid use associated with intracameral phenylephrine1.0%-ketorolac 0.3% administered during cataract surgery.
    Journal of cataract and refractive surgery, 2022, 07-01, Volume: 48, Issue:7

    Topics: Analgesics, Opioid; Cataract; Double-Blind Method; Epinephrine; Fentanyl; Humans; Ketorolac; Pain; P

2022
Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial.
    The American journal of emergency medicine, 2022, Volume: 58

    Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Dexamethasone; Double-Blin

2022
Comparison of the effect of ketorolac versus triamcinolone acetonide injections for the treatment of de Quervain's tenosynovitis: a double-blind randomized controlled trial.
    BMC musculoskeletal disorders, 2022, Sep-01, Volume: 23, Issue:1

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; De Quervain Disease; Humans; Keto

2022
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
    Quintessence international (Berlin, Germany : 1985), 2023, Feb-10, Volume: 54, Issue:2

    Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor

2023
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
    Quintessence international (Berlin, Germany : 1985), 2023, Feb-10, Volume: 54, Issue:2

    Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor

2023
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
    Quintessence international (Berlin, Germany : 1985), 2023, Feb-10, Volume: 54, Issue:2

    Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor

2023
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
    Quintessence international (Berlin, Germany : 1985), 2023, Feb-10, Volume: 54, Issue:2

    Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor

2023
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
    Quintessence international (Berlin, Germany : 1985), 2023, Feb-10, Volume: 54, Issue:2

    Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor

2023
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
    Quintessence international (Berlin, Germany : 1985), 2023, Feb-10, Volume: 54, Issue:2

    Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor

2023
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
    Quintessence international (Berlin, Germany : 1985), 2023, Feb-10, Volume: 54, Issue:2

    Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor

2023
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
    Quintessence international (Berlin, Germany : 1985), 2023, Feb-10, Volume: 54, Issue:2

    Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor

2023
Effectiveness of oral premedication of meloxicam, ketorolac, dexamethasone, and ibuprofen on the success rate of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a prospective, double-blind, randomized controlled trial.
    Quintessence international (Berlin, Germany : 1985), 2023, Feb-10, Volume: 54, Issue:2

    Topics: Anesthesia, Dental; Anesthetics, Local; Dexamethasone; Double-Blind Method; Humans; Ibuprofen; Ketor

2023
Effect of Preoperative Oral Steroids in Comparison to Anti-inflammatory on Anesthetic Success of Inferior Alveolar Nerve Block in Mandibular Molars with Symptomatic Irreversible Pulpitis-A Double-blinded Randomized Clinical Trial.
    Journal of endodontics, 2023, Volume: 49, Issue:4

    Topics: Anesthesia, Dental; Anesthetics, Local; Anti-Inflammatory Agents; Dexamethasone; Double-Blind Method

2023
Ketorolac Is Not More Effective Than Flunixin Meglumine or Phenylbutazone in Reducing Foot Pain in Horses.
    Journal of equine veterinary science, 2020, Volume: 94

    Topics: Animals; Clonixin; Cross-Over Studies; Horse Diseases; Horses; Ketorolac; Lameness, Animal; Pain; Ph

2020
Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study.
    The American journal of emergency medicine, 2019, Volume: 37, Issue:6

    Topics: Adult; Analgesics; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Metho

2019
Efficacy of pethidine, ketorolac, and lidocaine gel as analgesics for pain control in shockwave lithotripsy: A single-blinded randomized controlled trial.
    Investigative and clinical urology, 2019, Volume: 60, Issue:4

    Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non-

2019
Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:20

    Topics: Acetaminophen; Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster

2014
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.
    Obstetrics and gynecology, 2015, Volume: 126, Issue:1

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Administration

2015
Comparisons of ice packs, hot water immersion, and analgesia injection for the treatment of centipede envenomations in Taiwan.
    Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:7

    Topics: Adult; Analgesics, Opioid; Animals; Arthropod Venoms; Arthropods; Cold Temperature; Cryotherapy; Fem

2009
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
    Obstetrics and gynecology, 2009, Volume: 114, Issue:6

    Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non

2009
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
    Obstetrics and gynecology, 2009, Volume: 114, Issue:6

    Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non

2009
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
    Obstetrics and gynecology, 2009, Volume: 114, Issue:6

    Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non

2009
Paracervical block with combined ketorolac and lidocaine in first-trimester surgical abortion: a randomized controlled trial.
    Obstetrics and gynecology, 2009, Volume: 114, Issue:6

    Topics: Abortion, Induced; Adult; Anesthesia, Obstetrical; Anesthetics, Local; Anti-Inflammatory Agents, Non

2009
A novel drug eluting ureteral stent: a prospective, randomized, multicenter clinical trial to evaluate the safety and effectiveness of a ketorolac loaded ureteral stent.
    The Journal of urology, 2010, Volume: 183, Issue:3

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug-Eluting

2010
Effects of intrathecal ketorolac on human experimental pain.
    Anesthesiology, 2010, Volume: 112, Issue:5

    Topics: Adolescent; Adult; Capsaicin; Female; Hot Temperature; Humans; Injections, Spinal; Ketorolac; Male;

2010
Acetaminophen plus codeine compared to ketorolac in polytrauma patients.
    European review for medical and pharmacological sciences, 2010, Volume: 14, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents,

2010
Nitric oxide is negatively correlated to pain during acute inflammation.
    Molecular pain, 2010, Sep-15, Volume: 6

    Topics: Acute Disease; Adolescent; Adult; Female; Gene Expression Regulation, Enzymologic; Humans; Inflammat

2010
The efficacy of intravenous ketorolac for pain relief in single-stage adjustable strabismus surgery: a prospective, randomized, placebo-controlled trial.
    Eye (London, England), 2011, Volume: 25, Issue:2

    Topics: Adolescent; Adult; Analgesia; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cycloox

2011
Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans.
    Pain, 2011, Volume: 152, Issue:6

    Topics: Adult; Analgesics, Opioid; Blood Pressure; Cross-Over Studies; Cyclooxygenase Inhibitors; Double-Bli

2011
Noninfiltrative anesthesia for transrectal prostate biopsy: a randomized prospective study comparing lidocaine-prilocaine cream and lidocaine-ketorolac gel.
    Urologic oncology, 2013, Volume: 31, Issue:1

    Topics: Administration, Rectal; Aged; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, N

2013
A randomized, controlled trial validates a peripheral supra-additive antihyperalgesic effect of a paracetamol-ketorolac combination.
    Basic & clinical pharmacology & toxicology, 2011, Volume: 109, Issue:5

    Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Antipyretics; Cross-Over

2011
Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy.
    BJU international, 2012, Volume: 109, Issue:12

    Topics: Administration, Rectal; Aged; Anesthetics, Combined; Anesthetics, Local; Biopsy; Cyclooxygenase Inhi

2012
Effect of ketorolac 0.5% drops on patients' pain perception during intravitreal injection procedure.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2012, Volume: 28, Issue:5

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized;

2012
Effect of pretreatment with ketorolac on propofol injection pain.
    Acta anaesthesiologica Scandinavica, 2002, Volume: 46, Issue:8

    Topics: Adult; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Femal

2002
Comparison of intravenous ketorolac and meperidine in the treatment of biliary colic.
    The Journal of emergency medicine, 2002, Volume: 23, Issue:3

    Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Biliary Tract Diseases; Colic; D

2002
Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, May-15, Volume: 23, Issue:10

    Topics: Aged; Analgesia; Attitude to Health; Cognition; Conditioning, Operant; Consciousness; Female; Human

2003
Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain.
    Pain, 2003, Volume: 104, Issue:1-2

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analgesics; Anti-Inflammatory Agents, Non-Ster

2003
Effect of oral ketorolac and gender on human cold pressor pain tolerance.
    Clinical and experimental pharmacology & physiology, 2003, Volume: 30, Issue:10

    Topics: Administration, Oral; Adult; Analysis of Variance; Cold Temperature; Cross-Over Studies; Double-Blin

2003
Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac.
    Annals of emergency medicine, 2004, Volume: 43, Issue:2

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Double-Blind Method; Female

2004
Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac.
    Annals of emergency medicine, 2004, Volume: 43, Issue:2

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Double-Blind Method; Female

2004
Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac.
    Annals of emergency medicine, 2004, Volume: 43, Issue:2

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Double-Blind Method; Female

2004
Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac.
    Annals of emergency medicine, 2004, Volume: 43, Issue:2

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Child; Double-Blind Method; Female

2004
Parecoxib sodium demonstrates gastrointestinal safety comparable to placebo in healthy subjects.
    Journal of clinical gastroenterology, 2004, Volume: 38, Issue:7

    Topics: Adult; Cyclooxygenase Inhibitors; Double-Blind Method; Duodenal Ulcer; Endoscopy, Gastrointestinal;

2004
Appropriately timed analgesics control pain due to chest tube removal.
    American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2004, Volume: 13, Issue:4

    Topics: Aged; Analgesics, Opioid; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Chest Tubes

2004
Intravenous ketorolac significantly reduces the pain of office transrectal ultrasound and prostate biopsies.
    Urologia internationalis, 2004, Volume: 73, Issue:2

    Topics: Analgesia; Anti-Inflammatory Agents, Non-Steroidal; Biopsy, Needle; Humans; Injections, Intravenous;

2004
The effect of intravenous ketorolac on capsaicin-induced deep tissue hyperalgesia.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:3

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Cross-Over Studies; Double-Blind Method;

2006
Topical ketorolac 0.5% for ocular pain relief during scatter laser photocoagulation with 532 nm green laser.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2006, Volume: 22, Issue:6

    Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diabetic Retinopathy;

2006
Intravenous regional anesthesia using lidocaine and ketorolac.
    Anesthesia and analgesia, 1995, Volume: 81, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Conduction; Anesthesia, Intravenous; Anti-Infla

1995
Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain.
    Annals of emergency medicine, 1995, Volume: 26, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal;

1995
Reduction of pain and nausea after laparoscopic sterilization with bupivacaine, metoclopramide, scopolamine, ketorolac, and gastric suctioning.
    Obstetrics and gynecology, 1995, Volume: 85, Issue:5 Pt 1

    Topics: Analgesics, Non-Narcotic; Bupivacaine; Combined Modality Therapy; Female; Humans; Ketorolac; Laparos

1995
Prilocaine reduces injection pain caused by propofol.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:2

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anesthesia, Intravenous; Anti-Inflammatory Agents, Non-Steroi

1995
Clinical experience with ketorolac in children.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:9

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Drug Administra

1994
Use of ketorolac in the prevention of suxamethonium myalgia.
    British journal of anaesthesia, 1994, Volume: 73, Issue:6

    Topics: Adolescent; Adult; Analgesics; Atracurium; Female; Follow-Up Studies; Humans; Ketorolac; Male; Middl

1994
Ketorolac as a premedicant for coronary artery bypass surgery patients with normal ventricles.
    Nurse anesthesia, 1993, Volume: 4, Issue:4

    Topics: Aged; Analgesics; Blood Gas Analysis; Coronary Artery Bypass; Drug Therapy, Combination; Humans; Ket

1993
Subcutaneous ketorolac--a new development in pain control.
    Palliative medicine, 1993, Volume: 7, Issue:1

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; Female;

1993
Effects of interpleural bupivacaine on pleural chest tube removal pain: a randomized controlled trial.
    American journal of critical care : an official publication, American Association of Critical-Care Nurses, 1996, Volume: 5, Issue:2

    Topics: Aged; Analgesics, Opioid; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine;

1996
The effect of pretreatment with ketorolac on pain during intravenous injection of propofol.
    Anaesthesia, 1996, Volume: 51, Issue:9

    Topics: Adult; Ambulatory Surgical Procedures; Analgesics; Anesthetics, Intravenous; Double-Blind Method; Fe

1996
Effects of ketorolac versus bupivacaine coadministration during patient-controlled hydromorphone epidural analgesia after thoracotomy procedures.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:3

    Topics: Aged; Analgesia, Epidural; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Bupiva

1997
Effect of ketorolac in pediatric sickle cell vaso-occlusive pain crisis.
    Pediatric emergency care, 1999, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Anemia, Sickle Cell; Blood Vessels; Child; Double-Blind

1999
Pretreatment with ketorolac and venous occlusion to reduce pain on injection of propofol.
    Anaesthesia, 2000, Volume: 55, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Anti-Inflammatory Agents, Non-

2000
Pain responses in methadone-maintained opioid abusers.
    Journal of pain and symptom management, 2000, Volume: 20, Issue:4

    Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon

2000
Pain responses in methadone-maintained opioid abusers.
    Journal of pain and symptom management, 2000, Volume: 20, Issue:4

    Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon

2000
Pain responses in methadone-maintained opioid abusers.
    Journal of pain and symptom management, 2000, Volume: 20, Issue:4

    Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon

2000
Pain responses in methadone-maintained opioid abusers.
    Journal of pain and symptom management, 2000, Volume: 20, Issue:4

    Topics: Adult; Cold Temperature; Drug Interactions; Female; Humans; Hydromorphone; Ketorolac; Male; Methadon

2000
Cost effectiveness analysis of intravenous ketorolac and morphine for treating pain after limb injury: double blind randomised controlled trial.
    BMJ (Clinical research ed.), 2000, Nov-18, Volume: 321, Issue:7271

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Cost-Benefit A

2000
Ketorolac for sickle cell vaso-occlusive crisis pain in the emergency department: lack of a narcotic-sparing effect.
    Annals of emergency medicine, 1992, Volume: 21, Issue:8

    Topics: Acute Disease; Adult; Analgesics; Anemia, Sickle Cell; Double-Blind Method; Emergencies; Female; Hum

1992

Other Studies

96 other studies available for ketorolac and Ache

ArticleYear
Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and related compounds.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:8

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Male; Mice; Pain; Pyrroles; Rats; Structure-Ac

1985
Galactosyl prodrug of ketorolac: synthesis, stability, and pharmacological and pharmacokinetic evaluations.
    Journal of medicinal chemistry, 2009, Jun-25, Volume: 52, Issue:12

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Edem

2009
Synthesis and pharmacological evaluation of carbamic acid 1-phenyl-3-(4-phenyl-piperazine-1-yl)-propyl ester derivatives as new analgesic agents.
    Bioorganic & medicinal chemistry letters, 2012, Apr-01, Volume: 22, Issue:7

    Topics: Analgesics; Animals; Carbamates; Esters; Mice; Molecular Structure; Morphine; Pain; Pain Measurement

2012
Isobolographic analysis of antinociceptive effect of ketorolac, indomethacin, and paracetamol after simultaneous peripheral local and systemic administration.
    Behavioural pharmacology, 2022, 02-01, Volume: 33, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Dr

2022
Comparison of postcataract surgery anti-inflammatory regimens on the incidence of cystoid macular edema, iritis, pain, and photophobia.
    Journal of cataract and refractive surgery, 2023, 01-01, Volume: 49, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cataract; Dexamethasone; Humans; Incidence; Iritis; Ketorol

2023
Predictors and Trends of Opioid-Sparing Radical Prostatectomy From a Large National Cohort.
    Urology, 2022, Volume: 168

    Topics: Acetaminophen; Analgesics, Opioid; Bupivacaine; Humans; Ketorolac; Male; Pain; Prostatectomy; Roboti

2022
An analysis of harms reporting in systematic reviews regarding ketorolac for management of perioperative pain.
    British journal of anaesthesia, 2022, Volume: 129, Issue:5

    Topics: Analgesics, Opioid; Humans; Ketorolac; Ketorolac Tromethamine; Pain; Research Design; Systematic Rev

2022
Nitric Oxide and Opioids Involvement in Isobolographic Nsaids Antinociception.
    Drug research, 2019, Volume: 69, Issue:12

    Topics: Acetaminophen; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase

2019
Platelet Function: Meloxicam Intravenous in Whole Blood Samples From Healthy Volunteers.
    Clinical pharmacology in drug development, 2020, Volume: 9, Issue:7

    Topics: Adenosine Diphosphate; Administration, Intravenous; Adult; Anti-Inflammatory Agents, Non-Steroidal;

2020
Ketorolac used to control pain after photorefractive keratectomy.
    Journal of cataract and refractive surgery, 2020, Volume: 46, Issue:1

    Topics: Humans; Ketorolac; Lasers, Excimer; Pain; Pain Management; Photorefractive Keratectomy

2020
Effect of intracameral phenylephrine 1.0%-ketorolac 0.3% on postoperative cystoid macular edema, iritis, pain, and photophobia after cataract surgery.
    Journal of cataract and refractive surgery, 2020, Volume: 46, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cataract; Cataract Extraction; Cohort Studies; Humans; Irit

2020
Perioperative pain control and tympanostomy tube outcomes.
    International journal of pediatric otorhinolaryngology, 2020, Volume: 138

    Topics: Child, Preschool; Fentanyl; Humans; Infant; Ketorolac; Middle Ear Ventilation; Otitis Media with Eff

2020
Brachial plexus block versus wide-awake local anaesthesia for open reduction internal fixation surgery in distal radius fracture: A preliminary retrospective report.
    Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2021, Volume: 74, Issue:10

    Topics: Adult; Anesthesia, Local; Anti-Inflammatory Agents, Non-Steroidal; Brachial Plexus Block; Female; Fr

2021
Synergistic antinociceptive interaction of Syzygium aromaticum or Rosmarinus officinalis coadministered with ketorolac in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 94

    Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; Female; Herb-Drug Interactions; Ketorol

2017
Lidocaine/ketorolac-loaded biodegradable nanofibrous anti-adhesive membranes that offer sustained pain relief for surgical wounds.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Adhesives; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biocompatible Mater

2017
Mucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application.
    Drug delivery, 2018, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Alginates; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Drug Deli

2018
Antinociceptive tolerance to NSAIDs in the anterior cingulate cortex is mediated via endogenous opioid mechanism.
    BMC pharmacology & toxicology, 2018, 01-06, Volume: 19, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Tolerance; Gyrus Cing

2018
A randomized controlled trial comparing ketorolac and triamcinolone injections in adults with trigger digits.
    The Journal of hand surgery, European volume, 2018, Volume: 43, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Injections;

2018
Magnetic field distribution modulation of intrathecal delivered ketorolac iron-oxide nanoparticle conjugates produce excellent analgesia for chronic inflammatory pain.
    Journal of nanobiotechnology, 2018, May-16, Volume: 16, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Inflammation; Injections, Spinal; Ketorolac; Magne

2018
Effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam.
    Behavioural pharmacology, 2019, Volume: 30, Issue:5

    Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Diazepam; Electric Stimulation; Ketoro

2019
Response to Schiavenato, von Baeyer, and Craig's letter to the editor.
    Western journal of nursing research, 2013, Volume: 35, Issue:3

    Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce

2013
The CGRP receptor antagonist BIBN4096BS peripherally alleviates inflammatory pain in rats.
    Pain, 2013, Volume: 154, Issue:5

    Topics: Administration, Topical; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behav

2013
Iontophoretic transport kinetics of ketorolac in vitro and in vivo: demonstrating local enhanced topical drug delivery to muscle.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2014, Volume: 86, Issue:2

    Topics: Administration, Cutaneous; Animals; Drug Delivery Systems; Humans; Iontophoresis; Ketorolac; Kinetic

2014
Pharmacokinetics and analgesic effect of ketorolac floating delivery system.
    Drug delivery, 2015, Volume: 22, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Drug Delivery Systems;

2015
Antinociceptive tolerance to NSAIDs microinjected into dorsal hippocampus.
    BMC pharmacology & toxicology, 2014, Feb-28, Volume: 15

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Diclofenac;

2014
Management of stent symptoms: what a pain!
    BJU international, 2014, Volume: 114, Issue:6

    Topics: Cholinergic Antagonists; Humans; Ketorolac; Pain; Stents; Ureter; Ureteroscopy

2014
Pain and satisfaction during rigid cystoscopic ureteral stent removal: a preliminary study.
    BMC urology, 2014, Nov-18, Volume: 14

    Topics: Anesthetics, Intravenous; Anesthetics, Local; Cross-Sectional Studies; Cystoscopy; Device Removal; H

2014
Factors Associated With Discharge After Initial Emergency Treatment of Pediatric Migraine.
    Pediatric emergency care, 2017, Volume: 33, Issue:9

    Topics: Administration, Intranasal; Administration, Intravenous; Administration, Oral; Adolescent; Analgesic

2017
Contemporary open ureteral reimplantation without morphine: assessment of pain and outcomes.
    The Journal of urology, 2009, Volume: 182, Issue:3

    Topics: Analgesics; Child, Preschool; Female; Humans; Ketorolac; Male; Minimally Invasive Surgical Procedure

2009
Sample size/power calculations for repeated ordinal measurements in population pharmacodynamic experiments.
    Journal of pharmacokinetics and pharmacodynamics, 2010, Volume: 37, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Computer Simulation; Humans; Ketorolac; Models, Statistical

2010
Editorial comment.
    The Journal of urology, 2010, Volume: 183, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug-Eluting Stents; Humans; Ketorolac; Pain; Ureter; Urete

2010
Re: a novel drug eluting ureteral stent: a prospective, randomized, multicenter clinical trial to evaluate the safety and effectiveness of a ketorolac loaded ureteral stent: A. E. Krambeck, R. S. Walsh, J. D. Denstedt, G. M. Preminger, J. Li, J. C. Evans
    The Journal of urology, 2010, Volume: 184, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug-Eluting Stents; Humans; Ketorolac; Multicenter Studies

2010
Hesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in rats.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 97, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Chromatography, High Pressu

2011
Pediatric nurses' beliefs and pain management practices: an intervention pilot.
    Western journal of nursing research, 2011, Volume: 33, Issue:6

    Topics: Analgesics; Feasibility Studies; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Pilo

2011
Opioid sensitivity of nucleus raphe magnus ater analgesia by nonsteroidal anti-inflammatory drugs.
    Georgian medical news, 2011, Issue:190

    Topics: Analgesia; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug Inte

2011
Bridging the gap between pain assessment and treatment: time for a new theoretical approach?
    Western journal of nursing research, 2011, Volume: 33, Issue:6

    Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce

2011
Self-report is a primary source of information about pain, but it is not infallible: a comment on "response to Voepel-Lewis's letter to the editor, 'bridging the gap between pain assessment and treatment: time for a new theoretical approach?'".
    Western journal of nursing research, 2013, Volume: 35, Issue:3

    Topics: Analgesics; Humans; Ibuprofen; Ketorolac; Nurses; Pain; Pediatric Nursing; Workforce

2013
Comparison of stone size and response to analgesic treatment in predicting outcome of patients with renal colic.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2002, Volume: 9, Issue:2

    Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Colic; Emergency Service, Hospital; Fem

2002
Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac.
    Anesthesiology, 2003, Volume: 98, Issue:1

    Topics: Anesthetics, Local; Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Dose-Response Relationship

2003
An evaluation of population D-optimal designs via pharmacokinetic simulations.
    Annals of biomedical engineering, 2003, Volume: 31, Issue:1

    Topics: AIDS Vaccines; Algorithms; Asthma; Clinical Trials as Topic; Computer Simulation; Dose-Response Rela

2003
Management of vaso-occlusive pain in children with sickle cell disease.
    Journal of pediatric hematology/oncology, 2003, Volume: 25, Issue:4

    Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anemia, Sickle Cell; Anti-Infl

2003
Ketorolac may control more than pain.
    Clinical science (London, England : 1979), 2003, Volume: 105, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Burns; Humans; Ketorolac; Pain; Respiratory Distress Syndro

2003
Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats.
    Pain, 2003, Volume: 105, Issue:1-2

    Topics: Animals; Cervix Uteri; Cyclooxygenase Inhibitors; Dilatation; Electromyography; Estrogens; Female; I

2003
Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury.
    Neuroscience, 2003, Volume: 121, Issue:3

    Topics: Animals; Behavior, Animal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors;

2003
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
    European journal of pharmacology, 2004, Apr-26, Volume: 491, Issue:1

    Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh

2004
Nonsteroidal anti-inflammatory drugs increase expression of inducible COX-2 isoform of cyclooxygenase in spinal cord of rats with adjuvant induced inflammation.
    Brain research. Molecular brain research, 2004, Jun-18, Volume: 125, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhi

2004
A pilot study on the efficacy of ketorolac plus tramadol infusion combined with erythrocytapheresis in the management of acute severe vaso-occlusive crises and sickle cell pain.
    Haematologica, 2004, Volume: 89, Issue:11

    Topics: Adolescent; Analgesics; Anemia, Sickle Cell; Child; Child, Preschool; Combined Modality Therapy; Cyt

2004
Pain relief in those recovering from chemical dependency.
    American family physician, 2004, Nov-15, Volume: 70, Issue:10

    Topics: Administration, Inhalation; Albuterol; Anti-Inflammatory Agents, Non-Steroidal; Bronchodilator Agent

2004
Prospective audit of short-term concurrent ketamine, opioid and anti-inflammatory ('triple-agent') therapy for episodes of acute on chronic pain.
    Internal medicine journal, 2005, Volume: 35, Issue:1

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Analgesics; Analgesics, Opioid; Anti-Inflammatory Age

2005
Simplifying prehospital analgesia. Why certain medications should or should not be used for pain management in the field.
    JEMS : a journal of emergency medical services, 2005, Volume: 30, Issue:7

    Topics: Analgesics; Anesthetics, Combined; Butorphanol; Emergency Medical Services; Emergency Medical Techni

2005
The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception.
    Pain, 2006, Volume: 120, Issue:1-2

    Topics: Analgesia; Analgesics, Opioid; Animals; Antineoplastic Agents; Behavior, Animal; Bone Neoplasms; Che

2006
Quantification of analgesic use in children with sickle cell disease.
    The Clinical journal of pain, 2007, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Analgesics; Analgesics, Opioid; Anemia, Sickle Cell; Anti-Inflammatory Agents, No

2007
The local antinociceptive actions of nonsteroidal antiinflammatory drugs in the mouse radiant heat tail-flick test.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dipyrone; Disease

2007
Pharmacological validation of a model of cystitis pain in the mouse.
    Neuroscience letters, 2007, Jun-29, Volume: 421, Issue:3

    Topics: Analgesics; Animals; Behavior, Animal; Cyclophosphamide; Cystitis; Disease Models, Animal; Dose-Resp

2007
Intraoperative analgesia for day-care surgery: practice trends.
    JPMA. The Journal of the Pakistan Medical Association, 2007, Volume: 57, Issue:6

    Topics: Acetaminophen; Ambulatory Surgical Procedures; Analgesia; Analgesics; Analgesics, Non-Narcotic; Anal

2007
Ketorolac-dextran conjugates: synthesis, in vitro and in vivo evaluation.
    Acta pharmaceutica (Zagreb, Croatia), 2007, Volume: 57, Issue:4

    Topics: Acetic Acid; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buffers; Carrag

2007
The effects of intrathecal cyclooxygenase-1, cyclooxygenase-2, or nonselective inhibitors on pain behavior and spinal Fos-like immunoreactivity.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:3

    Topics: Animals; Behavior, Animal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor

2008
Spontaneously breathing technique for opioid tolerance.
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:4

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Inhalation; Anti-Inflammatory

2008
The analgesic and anti-inflammatory profile of (+/-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid (RS-37619).
    Agents and actions, 1982, Volume: 12, Issue:5-6

    Topics: Adrenal Cortex Hormones; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, No

1982
Effects of morphine and ketorolac on thermal allodynia induced by prostaglandin E2 and bradykinin in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:2

    Topics: Analgesics, Non-Narcotic; Animals; Azocines; Bradykinin; Dinoprostone; Female; Ketorolac; Macaca mul

1995
The use of ketorolac in lumbar spine surgery: a cost-benefit analysis.
    Journal of spinal disorders, 1995, Volume: 8, Issue:3

    Topics: Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Cost-Benefit Analysis; Drug Costs; Female; Hosp

1995
Ketorolac potentiates morphine antinociception during visceral nociception in the rat.
    Anesthesiology, 1994, Volume: 80, Issue:5

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Dose-Response Relationship, Dru

1994
NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:3

    Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-St

1994
Meperidine and ketorolac in the treatment of painful sickle cell crisis.
    Annals of emergency medicine, 1993, Volume: 22, Issue:10

    Topics: Analgesics; Anemia, Sickle Cell; Humans; Ketorolac; Meperidine; Pain; Tolmetin

1993
Antinociceptive activity of intrathecal ketorolac is blocked by the kappa-opioid receptor antagonist, nor-binaltorphimine.
    European journal of pharmacology, 1993, Sep-21, Volume: 242, Issue:1

    Topics: Analgesics; Animals; Drug Interactions; Drug Tolerance; Injections, Spinal; Ketorolac; Male; Mice; M

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Integrated assessment of pain scores and rescue morphine use during studies of analgesic efficacy.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:1

    Topics: Analgesics; Drug Evaluation; Humans; Ketorolac; Morphine; Pain; Pain Measurement; Tolmetin

1993
Comparison of the analgesic effects of ketorolac, morphine and aspirin in the rat.
    Proceedings of the Western Pharmacology Society, 1993, Volume: 36

    Topics: Analgesics; Animals; Aspirin; Dose-Response Relationship, Drug; Female; Ketorolac; Morphine; Pain; P

1993
Pain management with intravenous ketorolac.
    The Annals of pharmacotherapy, 1993, Volume: 27, Issue:3

    Topics: Adenocarcinoma; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Bile Duct Neoplasms; Chr

1993
Treatment of resistant pain in hypertrophic pulmonary arthropathy with ketorolac.
    Thorax, 1993, Volume: 48, Issue:4

    Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Carcinoma, Squamous Cell;

1993
NSAIDs and balanced analgesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1993, Volume: 40, Issue:5 Pt 1

    Topics: Analgesia; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Female; Humans; Infant; Ketor

1993
Problems and pitfalls in providing acute and short-term pain relief with nonsteroidal anti-inflammatory agents.
    The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1996, Volume: 148, Issue:1

    Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Hypersensitivity; Drug Int

1996
The effect of pretreatment with ketorolac on pain during intravenous injection of propofol.
    Anaesthesia, 1997, Volume: 52, Issue:1

    Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Pain; Propofol

1997
If you have no destination, any road will do.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1998, Volume: 5, Issue:2

    Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Ketorolac; Mus

1998
Drugs for pain.
    The Medical letter on drugs and therapeutics, 1998, Aug-14, Volume: 40, Issue:1033

    Topics: Acetaminophen; Administration, Oral; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Analgesics

1998
Antinociceptive effects of S(+)-ketoprofen and other analgesic drugs in a rat model of pain induced by uric acid.
    Journal of clinical pharmacology, 1998, Volume: 38, Issue:S1

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Biotransformation; Dise

1998
Spinal action of ketorolac, S(+)- and R(-)-ibuprofen on non-noxious activation of the catechol oxidation in the rat locus coeruleus: evidence for a central role of prostaglandins in the strychnine model of allodynia.
    Anesthesiology, 1999, Volume: 90, Issue:1

    Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Catechols; Electrophys

1999
Cross sensitivities. Medication errors waiting to happen.
    The American journal of nursing, 1999, Volume: 99, Issue:2

    Topics: Analgesics, Non-Narcotic; Aspirin; Asthma; Cross Reactions; Drug Hypersensitivity; Drug Interactions

1999
Effect of coadministration of caffeine and either adenosine agonists or cyclic nucleotides on ketorolac analgesia.
    European journal of pharmacology, 1999, Jul-21, Volume: 377, Issue:2-3

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Administration, Topical; Analgesics, Non-Narcotic; Animals;

1999
Analgesia for termination of pregnancy.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1999, Volume: 89, Issue:8

    Topics: Abortion, Induced; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Ketorolac; P

1999
Drugs for pain.
    The Medical letter on drugs and therapeutics, 2000, Aug-21, Volume: 42, Issue:1085

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal

2000
Ketorolac versus morphine for severe pain. Ketorolac is more effective, cheaper, and has fewer side effects.
    BMJ (Clinical research ed.), 2000, Nov-18, Volume: 321, Issue:7271

    Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Drug Costs; Humans; Ketorolac; Morphine

2000
Antinociceptive effects of delta-opioid agonists in Rhesus monkeys: effects on chemically induced thermal hypersensitivity.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:3

    Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Capsai

2001
Treatment of vinorelbine-associated tumor pain.
    American journal of clinical oncology, 2001, Volume: 24, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Bone Neoplasms; F

2001
Participation of the nitric oxide-cyclic GMP-ATP-sensitive K(+) channel pathway in the antinociceptive action of ketorolac.
    European journal of pharmacology, 2001, Aug-24, Volume: 426, Issue:1-2

    Topics: Adenosine Triphosphate; Analgesics; Animals; Behavior, Animal; Cyclic AMP; Dose-Response Relationshi

2001
Sickle cell vaso-occlusive pain crisis in adults: alternative strategies for management in the emergency department.
    Southern medical journal, 1992, Volume: 85, Issue:8

    Topics: Acetaminophen; Adolescent; Adult; Amitriptyline; Analgesics; Anemia, Sickle Cell; Anti-Inflammatory

1992
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1992, Volume: 63, Issue:9 Suppl

    Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin

1992
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
    Der Orthopade, 1992, Volume: 21, Issue:9 Suppl

    Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin

1992
[Pain therapy with Toratex. Official satellite symposium of the Xth World Congress of Anesthesiology. The Haague, 15 June 1992].
    Der Anaesthesist, 1992, Volume: 41, Issue:9 Suppl

    Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin

1992
Ketorolac in the treatment of acute pain: the pendulum swings.
    Annals of emergency medicine, 1992, Volume: 21, Issue:8

    Topics: Acute Disease; Analgesics; Humans; Ketorolac; Pain; Tolmetin

1992
Relief of pain by ketorolac or alcohol?
    Anesthesia and analgesia, 1992, Volume: 75, Issue:1

    Topics: Analgesics; Autonomic Nerve Block; Autonomic Nervous System Diseases; Ethanol; Humans; Injections, I

1992
[Introductory Press Conference: Toratex--the new mono-analgesics in acute, intense pain. Frankfurt, 21 February 1992].
    Der Internist, 1992, Volume: 33, Issue:5 Suppl

    Topics: Acute Disease; Analgesics; Humans; Ketorolac; Pain; Tolmetin

1992
Use of ketorolac in sickle-cell disease and vaso-occlusive crisis.
    Lancet (London, England), 1991, Sep-07, Volume: 338, Issue:8767

    Topics: Adult; Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ketorolac; Pain

1991
[Associated symposium: Ketorolac in drug therapy for pain relief. Berlin, October 25, 1991].
    Der Anaesthesist, 1991, Volume: 40, Issue:12 Suppl

    Topics: Analgesics; Humans; Ketorolac; Pain; Tolmetin

1991
Intravenous regional block using ketorolac: preliminary results in the treatment of reflex sympathetic dystrophy.
    Anesthesia and analgesia, 1992, Volume: 74, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Injections, Intravenous; Ketorolac;

1992
[Treatment of moderate and severe pain. Ketorolac--a new analgesic].
    Fortschritte der Medizin, 1991, Oct-30, Volume: 109, Issue:31

    Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Ketorolac; P

1991
Place of ketorolac in pain management.
    Clinical pharmacy, 1990, Volume: 9, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ketorolac; Pain; Tolmetin

1990