kainic acid has been researched along with Aura in 672 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (8.33) | 18.7374 |
| 1990's | 118 (17.56) | 18.2507 |
| 2000's | 231 (34.38) | 29.6817 |
| 2010's | 192 (28.57) | 24.3611 |
| 2020's | 75 (11.16) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y; Liu, Q; Liu, Y; Tan, C; Wang, Y; Xu, T; Yang, J; Zhang, P | 1 |
| Bleich, A; Buchecker, V; Koska, I; Pace, C; Palme, R; Potschka, H; Talbot, SR | 1 |
| Hagman, S; Kapucu, FE; Kiiski, H; Lotila, J; Mzezewa, R; Narkilahti, S; Peltola, J; Vinogradov, A | 1 |
| Burjanadze, M; Dashniani, M; Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lagani, V; Lepsveridze, E; Lordkipanidze, T; Solomonia, R; Tsverava, L | 1 |
| Friedman, LK; Kahen, BA; Velíšek, L; Velíšková, J | 1 |
| Gao, DS; Hu, JM; Xi, W; Yin, L; Zhong, C | 1 |
| Algradi, AM; Guan, W; Jiang, Y; Kuang, H; Li, X; Liu, Y; Pan, J; Wang, S; Yang, B; Zhou, Y | 1 |
| Delandre, C; Fujimoto, S; Haginoya, K; Hamano, SI; Hirose, S; Inoue, Y; Ishii, A; Kaneko, S; Miyamoto, H; Moore, AW; Morimoto, M; Oguni, H; Ohmori, I; Osaka, H; Osawa, M; Pai, YJ; Raveau, M; Shimohata, A; Sudo, G; Suzuki, T; Takahashi, Y; Tatsukawa, T; Uematsu, M; Yamakawa, K | 1 |
| Huang, L; Lin, A; Lü, Y; Qin, Z; Song, J; Yang, W; Yu, W; Zhang, W; Zhong, F | 1 |
| Hage, Z; Tsirka, SE; Victor, TR | 1 |
| Chen, D; Gan, CL; Gu, X; Hu, L; Lee, TH; Li, R; Mei, Y; Shui, X; Tian, Y; Wang, J; Wang, L; Zhang, M; Zhang, T; Zou, Y | 1 |
| Cheng, Y; Cui, Y; Liang, J; Pan, X; Sun, H; Wang, Q; Xin, W; Yu, J; Zhai, Y; Zhang, M; Zhang, W | 1 |
| Ding, J; Li, Y; Liu, L; Wang, Q; Wang, X; Xia, L; Zhang, Y | 1 |
| Castillo, PE; Frechou, MA; Gonçalves, JT; Nasrallah, K; Persaud, S; Yoon, YJ | 1 |
| Fu, J; Lv, K; Sun, W; Wang, J; Yin, X; Zhang, J | 1 |
| Behzadi, G; Davoudi, S; Hosseinmardi, N; Janahmadi, M; Khatibi, VA; Mirnajafi-Zadeh, J; Mohammadi, M; Nazari, M; Rahdar, M; Raoufy, MR; Rezaei, M | 1 |
| Bentley, R; Hu, G; Jiang, X; Lowe, S; Mei, H; Sun, C; Wu, Y; Xie, R; Zhao, W | 1 |
| Chen, C; Dong, X; Fan, J; Gong, L; He, D; Jiang, J; Jiang, P; Kuang, H; Kuang, R; Lin, D; Shen, W; Wang, X; Xia, N; Xie, Y; Zeng, L | 1 |
| Guo, Y; Hao, L; Jing, W; Peng, X; Wang, X; Yang, M; Yang, Y; Zhang, H | 1 |
| Calvani, M; Giovannini, MG; Lana, D; Landucci, E; Magni, G; Mazzantini, C; Pellegrini-Giampietro, DE | 1 |
| Barheier, N; Häussler, U; Kilias, A; Ruther, P; Tulke, S | 1 |
| Jung, SY; Kang, JW; Kim, DW; Kwon, HH; Park, H; Shin, HJ; Song, HJ | 1 |
| Babae, JF; Jogataei, MT; Mohammadi, E; Nikbakht, F; Vazifekhah, S | 1 |
| Aguirre-Aranda, I; Ángel Ávila-Rodríguez, M; Avendaño-Estrada, A; Diaz-Ruiz, A; Franco-Pérez, J; Islas-Cortez, M; Manjarrez-Marmolejo, J; Méndez-Armenta, M; Ríos, C; Ruiz-Diaz, A | 1 |
| Li, D; Lin, J; Liu, R; Long, M; Zhang, L; Zhang, X; Zhou, S | 1 |
| Krook-Magnuson, E; Smith, MM; Stieve, BJ | 1 |
| Hu, D; Liu, J; Ma, Y; Tang, F; Yan, Y; Zhang, Z | 1 |
| Li, J; Sha, L; Xu, Q | 1 |
| Hashemi, P; Izadpanah, E; Moloudi, MR; Vahabzadeh, Z | 1 |
| Bedner, P; Henning, L; Khan, D; Lülsberg, F; Muhammad, S; Müller, J; Prinz, M; Steinhäuser, C | 1 |
| Bonn, WV; Cathey, M; Cook, P; Gomez, FM; Krucik, DDR; Le-Bert, C; Meegan, JM | 1 |
| Chu, PC; Fisher, RS; Huang, CS; Ing, SZ; Liu, HL; Yu, HY | 1 |
| Chen, B; Guo, Y; Jiang, L; Lin, A; Lin, P; Tao, K; Xu, D; Zhang, H | 1 |
| Chen, Z; Dai, S; Fei, F; Li, Z; Ping, Y; Shao, Y; Shi, J; Tan, N; Wang, Y; Wu, D; Xin, H | 1 |
| Chen, Z; Cho, WS; Dai, SJ; Li, ZS; Nishibori, M; Park, SB; Qiu, XY; Shao, YY; Shi, JY; Sun, JY; Wang, Y; Xu, CL; Yan, MQ; Yi, S; Zheng, Y | 1 |
| Behzadi, G; Davoudi, S; Dehghan, S; Hosseinmardi, N; Janahmadi, M; Javan, M; Khatibi, VA; Mirnajafi-Zadeh, J; Nazari, M; Rahdar, M; Raoufy, MR; Rezaei, M; Salimi, M | 1 |
| Barbé, K; Bjerke, M; Custers, ML; Kaltenböck, L; Smolders, I; Van Eeckhaut, A; Vande Vyver, M | 1 |
| Fu, T; Kong, H; Wang, Y; Zhuo, Z | 1 |
| Buszka, A; Dzwonek, J; Kalita, K; Kruk, PK; Nader, K; Olech-Kochańczyk, G; Skupien-Jaroszek, A; Wilczynski, GM; Wójtowicz, T; Worch, R; Włodarczyk, J | 1 |
| Geng, C; Li, A; Li, J; Liu, C; Liu, P; Wu, J; Zhu, Q | 1 |
| Kovac, S; Saadi, A; Sandouka, S; Shekh-Ahmad, T; Taiwo, RO | 1 |
| Ameli, C; Cordero-Maldonado, ML; Crawford, AD; Donato, C; Martins, TG; Mombaerts, L; Peri, F; Skupin, A; Soliman, R | 1 |
| Christian-Hinman, CA; Conklin, EA; Lawande, NV | 1 |
| Dzwonek, J; Grajkowska, W; Marchel, A; Matyja, E; Rysz, A; Skupien-Jaroszek, A; Szczepankiewicz, AA; Wilczynski, GM | 1 |
| Lieb, A; Mutti, A; Schwarzer, C; Widmann, M | 1 |
| Annamneedi, A; Blondiaux, A; Çalışkan, G; Dityatev, A; Fejtova, A; Gundelfinger, ED; Jia, S; Montenegro-Venegas, C; Nebel, J; Seidenbecher, CI; Stork, O; Walker, MC; Wykes, RC | 1 |
| Bukovac, A; Drexel, M; Matulewicz, P; Rahimi, S; Ramos-Prats, A; Salami, P; Schmuck, A; Tasan, RO | 1 |
| Colegrove, K; Cook, P; Dennison, S; Fauquier, D; Gulland, F; Rowles, TK; Simeone, C; Skidmore, J | 1 |
| Fan, Y; Hou, C; Jiang, G; Peng, S; Tang, F; Wang, X; Wang, Y; Yang, J; Yu, J | 1 |
| Audinat, E; Blaquiere, M; Canet, G; de Bock, F; Garbelli, R; Givalois, L; Klement, W; Marchi, N; Pastori, C; Reutelingsperger, C; Rossini, L; Sheikh, M; Solito, E; Zub, E | 1 |
| Hu, J; Xia, H; Yan, Y; Zhang, B | 1 |
| Deng, L; Liu, G; Lu, J; Yang, P; Zhou, N | 1 |
| Dib, L; Fontana, A; Fritschy, JM; Gschwind, T; Lafourcade, C; Paterna, JC; Rambousek, L | 1 |
| Bedner, P; Deshpande, T; Henning, L; Li, T; Müller, J; Seifert, G; Steinhäuser, C; Wu, Z | 1 |
| Fox, P; Koh, S; Mithal, DS; Sanchez, RM; Somogyi, JR; Vien, AC | 1 |
| Bayat, A; Joshi, S; Koubeissi, MZ; Kurada, L; Siddu, M; Skopin, MD; Zelano, CM | 1 |
| Cho, E; Choi, Y; Hwang, H; Jang, J; Kim, S; Koh, HY; Lee, AR; Lee, J; Park, M; Seo, J; Sohn, H | 1 |
| Bell, TA; Dalton, KA; Gu, B; Hock, P; Miller, DR; Pan, Y; Pardo-Manuel de Villena, F; Philpot, BD; Shaw, GD; Shorter, JR; Williams, LH | 1 |
| He, H; Huang, Y; Lin, L; Pan, X; Wang, L; Wu, Y; Zhang, Y; Zhao, Y | 1 |
| Li, YZ; Sun, Z; Xu, HR; Zeng, CQ; Zhang, QG | 1 |
| Feixiang, S; Guo, M; Haiyan, G; Jiahang, S; Jie, L; Shengjie, S; Sihua, Q; Xiaoying, G; Yanmei, Z; Ying, C | 1 |
| Baluchnejadmojarad, T; Barati, H; Goudarzi, M; Jamali-Raeufy, N; Roghani, M | 1 |
| Moreira, JD; Müller, AP; Porciúncula, LO; Siqueira, LV; Souza, DO; Vinadé, L | 1 |
| Bosco, DB; Chen, T; Dheer, A; Lennon, VA; Wei, Y; Wu, LJ; Wu, Q; Xie, M; Ying, Y; Zheng, J | 1 |
| Bergin, DH; Johne, M; Klein, P; Löscher, W; Schidlitzki, A; Twele, F; Welzel, L | 1 |
| Aronica, E; Cattalini, A; de Curtis, M; Gnatkovsky, V; Pereira, MF; Testa, G; van Vliet, EA; Vila Verde, D; Zimmer, T | 1 |
| Cheng, Z; Luo, X; Wang, R; Yu, F | 1 |
| Li, Y; Wang, P; Wang, Z; Yang, A; Zhang, Q; Zhang, Y | 1 |
| Bergonzi, MC; Buonvicino, D; Landucci, E; Mazzantini, C; Pellegrini-Giampietro, DE | 1 |
| Chen, Q; Jia, Y; Lin, Q; Pei, J; Wang, S; Yang, P; Zhong, Z | 1 |
| Diao, L; He, Q; Hu, Y; Li, H; Li, M; Liao, X; Lu, L; Yu, H | 1 |
| Cheng, W; Gao, Y; Li, S; Wang, X; Zhang, Y | 1 |
| de Oliveira, DL; Dos Santos, TG; Linazzi, AM; Moro, L; Rech, G | 1 |
| Bedner, P; Deshpande, T; Henning, L; Seifert, G; Steinhäuser, C; Wu, Z | 1 |
| Guo, Y; Huang, X; Lin, Z; Meng, L; Meng, W; Niu, L; Qi, L; Wang, Y; Yi, S; Zhou, H; Zou, J | 1 |
| Bie, B; Chen, Y; Li, H; Li, J; Sheng, L; Wang, Z; Ye, J; You, H; Zhang, Q | 1 |
| Guan, L; Li, H; Li, S; Li, X; Li, Y; Lin, J; Shi, Y; Yang, C; Zhang, Y | 1 |
| Audinat, E; Bacigaluppi, M; Cerovic, M; Di Nunzio, M; Di Sapia, R; Gullotta, GS; Kebede, V; Marchi, N; Ravizza, T; Sorrentino, D; Vezzani, A | 1 |
| Buchanan, RA; Consoli, DC; Dixit, S; Harrison, FE; May, JM; Nobis, WP; Tienda, AA; Wilcox, JM | 1 |
| Liang Hsieh, C; Liao, ET; Lin, YW; Tang, NY | 1 |
| Meng, ZY; Wang, FX; Xiong, XY; Yang, H; Yang, QW; Zhong, Q | 1 |
| Glauser, TA; Modi, AC; Rausch, JR; Steve White, H; Thomson, KE | 1 |
| Andrade, PA; Lukoyanov, NV; Maia, GH; Soares, JI; Valente, MC | 1 |
| Li, XM; Ma, XX; Ni, KM; Sun, P; Wei, X; Xu, M; Yang, CH; Yang, CR; Zhang, Y; Zhang, YJ | 1 |
| Cao, P; Li, Z; Liu, Z; Lv, C; Meng, X; Yang, C | 1 |
| Brazete, CS; Lukoyanov, NV; Luz, LL; Maia, GH; Soares, JI | 1 |
| Du, J; Han, Y; Jin, H; Li, Q; Niu, M; Qin, J; Zhang, J | 1 |
| Davanger, S; Egbenya, DL; Hammer, J; Lorgen, JØ | 1 |
| Chen, YC; Du, TT; Jiang, Y; Liu, DF; Liu, YY; Shi, L; Wang, X; Zhang, JG; Zhang, X; Zhu, GY | 1 |
| Bankstahl, M; Brandt, C; Bröer, S; Gerhauser, I; Klee, R; Li, D; Löscher, W; Meller, S; Rankovic, V; Römermann, K; Schidlitzki, A; Töllner, K; Twele, F; Waltl, I | 1 |
| Li, Y; Lu, S; Lu, X; Ma, Y; Tian, X; Wang, W; Wang, X; Xu, D; Xu, X; Yang, Y; Zhang, Y; Zheng, F | 1 |
| Hartman, AL; Holden, K | 1 |
| Calabrò, A; Gerace, E; Landucci, E; Mannaioni, G; Masi, A; Pellegrini-Giampietro, DE; Renzi, D; Resta, F | 1 |
| Alpdogan, S; Dibué-Adjei, M; Hescheler, J; Kamp, MA; Neiss, WF; Schneider, T; Tevoufouet, EE | 1 |
| Bonnot, A; Cohen, I; Eugène, E; Sieu, LA | 1 |
| Chen, X; Dong, G; Liu, Y; Lu, R; Wang, L; Yun, W; Zhou, X | 1 |
| Atanasova, D; Atanassova, N; Ivanova, N; Lazarov, N; Nenchovska, Z; Pavlova, E; Tchekalarova, J | 1 |
| Huang, H; Lu, X; Luo, Z; Qiu, X; Tang, S; Xu, Z; Zhang, Y | 1 |
| Aboulamer, S; Bosoi, CM; Carmant, L; Desgent, S; Gagné, J; Messiet, E; Sanon, NT; Simard, A; Wolf, DC | 1 |
| Aboufatima, R; Bezza, K; Chait, A; El Gabbas, Z; Ferehan, H; Kissani, N; Laadraoui, J; Marhoume, F; Sokar, Z; Wakrim, EM | 1 |
| Afonso, AR; Lukoyanov, NV; Maia, GH; Soares, JI | 1 |
| Abramov, AY; Dayalan Naidu, S; Dinkova-Kostova, AT; Eckel, R; Higgins, M; Kovac, S; Shekh-Ahmad, T; Walker, MC; Yamamoto, M | 1 |
| Du, M; Lu, Y; Sun, Z; Zeng, CQ | 1 |
| Chen, GH; Chen, XY; Ma, YL; Shi, JH; Song, LF; Suo, JF; Wang, L | 1 |
| Blauwblomme, T; Capelle, L; Chever, O; Couillin, I; Dossi, E; Guinard, E; Huberfeld, G; Le Bert, M; Moulard, J; Pallud, J; Rouach, N; Vasile, F | 1 |
| Huang, WS; Zhu, L | 1 |
| Dhir, A | 1 |
| Boylan, GB; Henshall, DC; Jimenez-Mateos, EM; Madden, SF; Molloy, EJ; Quinlan, SMM; Rodriguez-Alvarez, N | 1 |
| Bu, G; Chen, Z; Li, Y; Pan, G; Xu, H; Zhang, Y; Zheng, H | 1 |
| Chen, Y; Du, T; Jiang, Y; Liu, D; Liu, Y; Meng, D; Shi, L; Zhang, J; Zhang, X; Zhu, G | 1 |
| Chen, W; He, Q; Hu, Y; Jiang, L; Man, S; Wu, L | 1 |
| Åbjørsbråten, KS; Enger, R; Heuser, K; Jensen, V; Nagelhus, EA; Nome, CG; Pettersen, KH; Sprengel, R; Tang, W; Taubøll, E | 1 |
| Ali, ES; Atanasova, M; da Conceição Machado, K; da Silva Lopes, L; de Carvalho Melo-Cavalcante, AA; de Sousa Rios, MA; Dimitrova Tchekalarova, J; Găman, AM; Găman, MA; Islam, MA; Islam, MT; Khan, IN; Luiz Gomes, A; Mishra, SK; Mubarak, MS; Paz, MFCJ; Shill, MC; Yele, S | 1 |
| Hsieh, HL; Hsieh, TY; Huang, SK; Lin, TY; Lu, CW; Wang, SJ | 1 |
| Burman, RJ; Parrish, RR | 1 |
| Aronica, E; Colas, RA; Craparotta, I; Dalli, J; Foerch, P; Frigerio, F; Hansen, TV; Kaminski, RM; Leclercq, K; Marchini, S; Pasqualini, G; Perretti, M; Pistorius, K; Porcu, L; van Vliet, EA; Vandenplas, C; Vezzani, A | 1 |
| Billingsley, P; Metcalf, CS; Saunders, GW; Smith, MD; West, PJ; White, HS; Wilcox, KS | 1 |
| Barco, A; Del Blanco, B; Delgado-Garcia, JM; Gruart, A; Llinares, M; Medrano-Fernández, A; Olivares, R; Sánchez-Campusano, R | 1 |
| Arafat, MA; Budde, RB; Irazoqui, PP; Jefferys, JGR; Lovick, TA; Pederson, DJ | 1 |
| Bergstrom, RA; Jones, MV; Maganti, RK; Pfammatter, JA; Wallace, EP | 1 |
| Li, JY; Tian, RH | 1 |
| Aronica, E; Caban, B; Devijver, H; Gozdz, A; Grajkowska, W; Jaworski, J; Jaworski, T; Jozwiak, S; Kalita, K; Kazmierska-Grebowska, P; Konopacki, J; Kotulska, K; Kowalczyk, T; Lechat, B; Nader, K; Pijet, B; Sadowski, K; Urbanska, M; Van Leuven, F; van Vliet, EA | 1 |
| Albertini, MC; Ambrogini, P; Bartolini, D; Betti, M; Cuppini, R; Di Palma, M; Galli, F; Lattanzi, D; Marinelli, R; Minelli, A; Torquato, P | 1 |
| Chen, M; Jia, C; Jiao, H; Wei, L; Yang, H; Yin, W; Zhang, R | 1 |
| Díaz-Ruíz, A; Flores-Espinosa, P; Manjarrez, J; Méndez-Armenta, M; Nava-Ruíz, C; Ruíz-Díaz, A; Yescas-Gómez, P; Zaga-Clavellina, V | 1 |
| Dudek, FE; Grabenstatter, HL | 2 |
| Shi, XZ; Xu, Q | 1 |
| Bartolomei, F; Becker, C; Benoliel, JJ; Bernard, C; Brouillard, F; Claverie, D; Ghestem, A; Mancic, A; Poillerat, V | 1 |
| Gao, P; Huo, J; Niu, J; Sun, T; Wan, D; Wang, F; Wu, J; Yu, B; Zhang, J | 1 |
| Gao, L; Hou, S; Li, J; Liu, A; Liu, N; Ma, Z; Qiao, Z; Shen, H; Wang, F; Wei, L; Zhang, X | 1 |
| Gamkrelidze, G; Kandashvili, M; Kokaia, M; Lepsveridze, E; Lortkipanidze, T; Margvelani, G; Solomonia, R; Tsverava, L | 1 |
| Chen, Y; Du, T; Liu, D; Liu, Y; Shi, L; Yuan, T; Zhang, J; Zhang, X; Zhu, G | 1 |
| Gao, X; Pan, X; Sun, H; Wang, Q; Yu, H; Yu, J; Zhang, M; Zhang, Y; Zhu, W | 1 |
| Andrade, PA; Da Costa, C; Ferreira, MH; Lukoyanov, NV; Maia, GH; Soares, JI | 1 |
| Chen, O; Huang, S; Liu, J; Wang, Y; Xue, J; Zhu, W; Zhu, X | 1 |
| Beamer, E; Beynon, RJ; Hammond, D; Salter, MW; Sills, GJ; Simpson, D; Thippeswamy, T; Tse, K; Tymianski, M | 1 |
| Alessi, C; Cattalini, A; Colciaghi, F; de Curtis, M; Figini, M; Noè, F; Vila Verde, D; Zucca, I | 1 |
| Haas, CA; Häussler, U; Tulke, S | 1 |
| Bai, J; Gao, C; Gao, L; Li, Z; Wang, R | 1 |
| Li, F; Liu, L | 1 |
| Almeida, SG; Baptista, HX; Brazete, CS; Leite, JM; Lukoyanov, NV; Lukoyanova, AN; Maia, GH; Soares, JI | 1 |
| Al Hamda, MH; Dong, J; Xu, K; Yao, Y; Zhang, A; Zhu, M; Zhu, X | 1 |
| Abramov, AY; Christian Wigley, W; Gola, L; Kovac, S; Lieb, A; Shekh-Ahmad, T; Walker, MC | 1 |
| Godlevsky, LS; Godovan, VV; Kresyun, VI; Polyasny, VA | 1 |
| Chai, X; Frotscher, M; Haas, CA; Häussler, U; Kowalski, J; Münzner, G; Tinnes, S; Young, C; Zhao, S | 1 |
| Li, Z; Tang, Z; Wang, X; Zheng, H; Zheng, W | 1 |
| Bikashvili, T; Japaridze, N; Lordkipanidze, T; Zhvania, M | 1 |
| Grönman, M; Holopainen, IE; Järvelä, JT; Kukko-Lukjanov, TK; Laurén, HB; Lopez-Picon, FR; Ruohonen, S; Virta, JE | 1 |
| Miao, L; Shen, FZ; Sun, T; Wang, EJ; Wang, F; Xu, J; Xu, YL; Yang, GM | 1 |
| Bazan, N; Lu, Y; Pei, L; Shang, Y; Tian, Q; Wang, X; Wen, R; Yang, Y; Zhao, K; Zhu, LQ | 1 |
| Gorter, JA; Qiao, X; van Vliet, EA; Wadman, WJ; Werkman, TR | 1 |
| Currie, RW; Esser, MJ; Galic, MA; Moriyama, C; Mychasiuk, R; Perrot, TS; Pittman, QJ | 1 |
| Dirnagl, U; Dyrks, T; Graham, K; Harhausen, D; Khojasteh, U; Müller, J; Sudmann, V; Thiele, A; Wunder, A; Zille, M | 1 |
| Chang, PK; Charron, F; Dezsi, G; Gill, R; Huang, TC; Jones, NC; Machnes, ZM; McKinney, RA; O'Brien, TJ; Ozturk, E; Reist, N; Szyf, M | 1 |
| Kano, R; Kawai, K; Noda, T; Saito, N; Shiramatsu, TI; Takahashi, H; Usami, K | 1 |
| Chang, L; Hsu, CL; Huang, FL; Lai, TH; Shiao, YJ; Tsay, HJ; Tzeng, TT | 1 |
| Sha, LZ; Sha, ZQ; Shen, Y; Wu, XF; Xu, Q | 1 |
| Chen, Y; Hu, L; Hua, N; Zeng, L; Zhang, H | 1 |
| Delgado-García, JM; Duran, J; García-Rocha, M; Gruart, A; Guinovart, JJ | 1 |
| Ho, TY; Hsiang, CY; Hsieh, CL; Tang, NY | 1 |
| Buckmaster, PS; Gulland, FM; Toyoda, I; Van Bonn, W; Wen, X | 1 |
| Bauer, CS; Dolphin, AC; Jefferys, JG; Jiruska, P; Nieto-Rostro, M; Sandhu, G | 1 |
| Dibué, M; Hänggi, D; Hescheler, J; Kamp, MA; Neumaier, F; Schneider, T; Steiger, HJ | 1 |
| Gulland, FM; Ramsdell, JS | 1 |
| Baek, JH; Rubinstein, M; Scheuer, T; Trimmer, JS | 1 |
| Li, Y; Li, Z; Shen, F; Sun, T; Wang, F; Yang, G; Yang, W; Zhang, Z | 1 |
| Eyjolfsson, EM; Schousboe, A; Sonnewald, U; Waagepetersen, HS; Walls, AB | 1 |
| Averkin, RG; Beck, H; Bellistri, E; Menendez de la Prida, L; Miklitz, C; Müller, C; Pothmann, L; Remy, S; Uebachs, M | 1 |
| Hsieh, CL; Hsu, HC; Lin, WJ; Lin, YW; Liu, CH; Liu, HJ | 1 |
| Hsieh, CL; Lin, YW | 2 |
| Hui, L; Shen, F; Sun, T; Wang, F; Wang, Z; Yang, G; Zhang, X; Zhao, X; Zhou, W; Zhou, X | 1 |
| Andresen, L; Dulla, CG; Hampton, D; Maguire, J; Morel, L; Taylor-Weiner, A; Yang, Y | 1 |
| Hubens, CJ; Kaptein, PS; Schenk, GJ; ter Horst, JP; Voskuyl, RA | 1 |
| Crépel, V; Mulle, C | 1 |
| Chen, W; Hu, H; Huang, Y; Leng, T; Lu, B; Qiu, P; Su, X; Sun, H; Tang, L; Wang, Y; Yan, G; Yan, M; Yin, W; Zhang, J; Zhou, Y; Zhu, W | 1 |
| Dabrowski, M; Kaczmarek, L; Kalita, K; Kuzniewska, B; Nader, K | 1 |
| Song, C; Wang, S; Xiao, T; Xu, W; Zhang, X; Zhao, C; Zhao, M; Zhu, G | 1 |
| Benson, MJ; Borges, K; Hodson, MP; Lynch, JW; Talwar, S; Thomas, NK; Woodruff, TM | 1 |
| Chang, SJ; Tsai, HL | 1 |
| Borlongan, CV; Dailey, T; Kaneko, Y; Sullivan, R; Tajiri, N; Vale, FL | 1 |
| Chung, CK; Chung, YH; Jeong, JH; Kim, DJ; Kim, HC; Kim, HJ; Lee, SY; Nam, Y; Ong, WY; Park, ES; Shin, EJ; Tran, TV; Wie, MB | 1 |
| Benson, MJ; Borges, K; Manzanero, S | 1 |
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22 review(s) available for kainic acid and Aura
| Article | Year |
|---|---|
Curcumin in epilepsy disorders.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biological Availability; Brain; Curcuma; Curcumin; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mice; Rats; Seizures | 2018 |
Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: The role of vitamin E.
Topics: Animals; Antioxidants; Brain; Epilepsy; Humans; Inflammation; Kainic Acid; Neurodegenerative Diseases; Oxidative Stress; Vitamin E | 2019 |
Domoic acid epileptic disease.
Topics: Aged; Aged, 80 and over; Aging; Amnesia; Animal Diseases; Animals; Behavior, Animal; Bivalvia; Epilepsy; Epilepsy, Temporal Lobe; Female; Food Contamination; Hippocampus; Humans; Kainic Acid; Male; Marine Toxins; Middle Aged; Neuromuscular Depolarizing Agents; Neurotoxins; Olfactory Pathways; Rats; Recurrence; Sea Lions; Seizures; Shellfish Poisoning | 2014 |
Physiopathology of kainate receptors in epilepsy.
Topics: Animals; Anticonvulsants; Epilepsy; Humans; Kainic Acid; Neurotoxins; Receptors, Kainic Acid; Synapses | 2015 |
Role of JNK isoforms in the kainic acid experimental model of epilepsy and neurodegeneration.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Hippocampus; Humans; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Kainic Acid; MAP Kinase Signaling System; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 10; Nerve Degeneration | 2017 |
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Epilepsy, Reflex; Flurothyl; gamma-Aminobutyric Acid; Humans; Kainic Acid; Kindling, Neurologic; Muscarinic Agonists; Papio; Penicillins; Pentylenetetrazole; Pilocarpine; Tetanus Toxin; Zinc Compounds | 2010 |
Neurological disease rises from ocean to bring model for human epilepsy to life.
Topics: Animals; DDT; Disease Models, Animal; Epilepsy; Humans; Kainic Acid; Marine Toxins; Neurotoxins; Pesticides; Water Pollutants, Chemical | 2010 |
Complications associated with genetic background effects in models of experimental epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Genetic Predisposition to Disease; Humans; Kainic Acid; Phenotype; Seizures; Species Specificity | 2002 |
Basic science and epilepsy: experimental epilepsy surgery.
Topics: Amygdala; Animals; Anticonvulsants; Cats; Combined Modality Therapy; Corpus Callosum; Drug Evaluation; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Models, Animal; Neurosurgical Procedures; Nootropic Agents; Pyrrolidinones; Rats; Seizures; Stereotaxic Techniques | 2001 |
[Synaptic physiology of the kainate receptors and its influence in epileptogenesis].
Topics: Anticonvulsants; Epilepsy; Hippocampus; Humans; Kainic Acid; Neurons; Patch-Clamp Techniques; Receptors, Kainic Acid; Signal Transduction; Synapses | 2004 |
Kainate receptors in epilepsy and excitotoxicity.
Topics: Animals; Brain; Epilepsy; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Kainic Acid; Nerve Net; Neurotoxins; Receptors, Kainic Acid; Synaptic Transmission | 2009 |
Kainic acid: The neurotoxic breakthrough.
Topics: Animals; Epilepsy; Hippocampus; Huntington Disease; Kainic Acid; Neurotoxins; Pyrrolidines; Receptors, Cell Surface; Receptors, Glutamate; Retina | 1982 |
Role of excitatory pathways in the hippocampal damage produced by kainic acid.
Topics: Animals; Epilepsy; Hippocampus; Injections, Intraventricular; Kainic Acid; Neural Pathways; Neurons; Pyrrolidines; Rats | 1981 |
Minireview. Kainic acid as a tool for the study of temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Cell Survival; Central Nervous System; Electrophysiology; Epilepsy; Epilepsy, Temporal Lobe; Injections; Kainic Acid; Limbic System; Neurons; Pyrrolidines; Rats | 1981 |
Kainic acid seizures in the rat.
Topics: Animals; Behavior, Animal; Brain; Electroencephalography; Epilepsy; Kainic Acid; Neuronal Plasticity; Rats; Seizures | 1994 |
[Receptive mechanisms of excitatory amino acid signals].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Brain Ischemia; Epilepsy; Ibotenic Acid; Kainic Acid; Ligands; N-Methylaspartate; Receptors, Amino Acid; Signal Transduction; Transcription Factors | 1993 |
The development of epilepsy in the paediatric brain.
Topics: Age Factors; Animals; Baclofen; Child; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Humans; Infant, Newborn; Kainic Acid; Kindling, Neurologic; Phenytoin; Rats; Receptors, GABA-A; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate | 1994 |
Epileptogenic effects of status epilepticus.
Topics: Animals; Brain; Brain Damage, Chronic; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; Humans; Kainic Acid; Rats; Status Epilepticus | 1993 |
Hypothetical mechanisms for the cellular and neurophysiologic basis of secondary epileptogenesis: proposed role of synaptic reorganization.
Topics: Animals; Dentate Gyrus; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Nerve Net; Rats; Receptors, N-Methyl-D-Aspartate; Synapses | 1997 |
[Stimulating amino acids in epilepsy: possibilities of treatment].
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Asparagine; Epilepsy; Female; Glutamine; Humans; Kainic Acid; Male; N-Methylaspartate; Synaptic Transmission | 2000 |
Inhibitors of AMPA and kainate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Epilepsy; Humans; Kainic Acid; Receptors, AMPA; Receptors, Kainic Acid | 2001 |
Excitatory transmitters and epilepsy-related brain damage.
Topics: Acetylcholine; Amygdala; Animals; Brain; Cholinesterase Inhibitors; Convulsants; Electric Stimulation; Epilepsy; Kainic Acid; Lithium; Nerve Degeneration; Neural Pathways; Neurons; Neurotransmitter Agents; Piperidines; Rats; Somatosensory Cortex; Synaptic Transmission | 1985 |
1 trial(s) available for kainic acid and Aura
| Article | Year |
|---|---|
Nicotine and kainic acid effects on cortical epileptic afterdischarges in immature rats.
Topics: Action Potentials; Animals; Animals, Newborn; Cerebral Cortex; Drug Interactions; Epilepsy; Kainic Acid; Male; Nicotine; Rats; Rats, Wistar; Treatment Outcome | 2012 |
649 other study(ies) available for kainic acid and Aura
| Article | Year |
|---|---|
G-alpha interacting protein interacting protein, C terminus 1 regulates epileptogenesis by increasing the expression of metabotropic glutamate receptor 7.
Topics: Adaptor Proteins, Signal Transducing; Animals; Brain; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Male; Mice; Receptors, Metabotropic Glutamate | 2022 |
Toward Evidence-Based Severity Assessment in Mouse Models with Repeated Seizures: (II.) Impact of Surgery and Intrahippocampal Kainate.
Topics: Animals; Corticosterone; Disease Models, Animal; Epilepsy; Kainic Acid; Mice; Seizures; Status Epilepticus | 2023 |
A kainic acid-induced seizure model in human pluripotent stem cell-derived cortical neurons for studying the role of IL-6 in the functional activity.
Topics: Cytokines; Epilepsy; Humans; Interleukin-6; Kainic Acid; Neurons; Pluripotent Stem Cells; Seizures | 2022 |
Myo-Inositol Limits Kainic Acid-Induced Epileptogenesis in Rats.
Topics: Animals; Antinematodal Agents; Disease Models, Animal; Epilepsy; Inositol; Kainic Acid; Male; Memory Disorders; Rats; Rats, Wistar; Seizures; Vitamin B Complex | 2022 |
Sex differences in behavioral pathology induced by subconvulsive stimulation during early postnatal life are overcome by epileptic activity in the pre-juvenile weanling period.
Topics: Animals; Epilepsy; Female; Flurothyl; Hippocampus; Humans; Kainic Acid; Male; Rats; Seizures; Sex Characteristics; Status Epilepticus | 2022 |
Long-term development of dynamic changes in neurovascular coupling after acute temporal lobe epilepsy.
Topics: Animals; Brain; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Neurovascular Coupling | 2022 |
The Aerial Parts of
Topics: Animals; Anticonvulsants; Bupleurum; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Plant Components, Aerial; Rats | 2022 |
CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Genome-Wide Association Study; Hippocampus; Homeodomain Proteins; Humans; Kainic Acid; Mice; Seizures; Synaptic Transmission | 2022 |
GPR120 modulates epileptic seizure and neuroinflammation mediated by NLRP3 inflammasome.
Topics: Animals; Caspases; Epilepsy; Epilepsy, Temporal Lobe; Humans; Inflammasomes; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Receptors, G-Protein-Coupled; Status Epilepticus | 2022 |
Prophylactic Administration of Cannabidiol Reduces Microglial Inflammatory Response to Kainate-Induced Seizures and Neurogenesis.
Topics: Animals; Anticonvulsants; Cannabidiol; Epilepsy; Humans; Kainic Acid; Mice; Microglia; Neurogenesis; Seizures | 2022 |
Blocking ERK-DAPK1 Axis Attenuates Glutamate Excitotoxicity in Epilepsy.
Topics: Animals; Death-Associated Protein Kinases; Epilepsy; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Humans; Kainic Acid; Mice; Seizures | 2022 |
Anti-Seizure and Neuronal Protective Effects of Irisin in Kainic Acid-Induced Chronic Epilepsy Model with Spontaneous Seizures.
Topics: Animals; Brain-Derived Neurotrophic Factor; Epilepsy; Fibronectins; Hippocampus; Kainic Acid; Rats; Rats, Sprague-Dawley; Seizures | 2022 |
Inhibiting SRC activity attenuates kainic-acid induced mouse epilepsy via reducing NR2B phosphorylation and full-length NR2B expression.
Topics: Animals; Calpain; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Phosphorylation; Seizures | 2022 |
Seizure-induced strengthening of a recurrent excitatory circuit in the dentate gyrus is proconvulsant.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy; Kainic Acid; Long-Term Potentiation; Mice; Mossy Fibers, Hippocampal; Seizures | 2022 |
Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy.
Topics: Animals; Brain; Carbamazepine; Drug Resistant Epilepsy; Epilepsy; Kainic Acid; Ketoconazole; Mice; Micelles; Nanoparticles; Polyethylene Glycols; Pregnane X Receptor | 2022 |
The Glycolysis Inhibitor 2-Deoxy-D-Glucose Exerts Different Neuronal Effects at Circuit and Cellular Levels, Partially Reverses Behavioral Alterations and does not Prevent NADPH Diaphorase Activity Reduction in the Intrahippocampal Kainic Acid Model of Te
Topics: Animals; Deoxyglucose; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Glucose; Glycolysis; Hippocampus; Kainic Acid; NADP; NADPH Dehydrogenase; Neurons | 2023 |
Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway.
Topics: Animals; Anticonvulsants; Epilepsy; Ferroptosis; Glutamic Acid; Kainic Acid; Mice; Neuroprotective Agents; NF-E2-Related Factor 2; Polyphenols; Quercetin; Seizures; Signal Transduction; Sirtuin 1 | 2022 |
Captopril alleviates epilepsy and cognitive impairment by attenuation of C3-mediated inflammation and synaptic phagocytosis.
Topics: Animals; Captopril; Cognitive Dysfunction; Epilepsy; Inflammation; Kainic Acid; Phagocytosis; Rats; Rats, Sprague-Dawley | 2022 |
Decreased Spire2 Expression is Involved in Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Seizures | 2022 |
Cannabidiol inhibits microglia activation and mitigates neuronal damage induced by kainate in an in-vitro seizure model.
Topics: Animals; Cannabidiol; Dronabinol; Epilepsy; Kainic Acid; Microglia; Rats; Seizures | 2022 |
Integration of the CA2 region in the hippocampal network during epileptogenesis.
Topics: Animals; Dentate Gyrus; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kainic Acid; Mice; Mossy Fibers, Hippocampal; Seizures | 2023 |
Oxygenated Water Increases Seizure Threshold in Various Rodent Seizure Models.
Topics: Animals; Betamethasone; Epilepsy; Kainic Acid; Oxygen; Rodentia; Seizures; Spasm; Water | 2022 |
Evaluation the cognition-improvement effects of N-acetyl cysteine in experimental temporal lobe epilepsy in rat.
Topics: Acetylcysteine; Animals; Cognition; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Maze Learning; Memory Disorders; Rats; TOR Serine-Threonine Kinases | 2023 |
Characterization of the anticonvulsant effect of dapsone on metabolic activity assessed by [
Topics: Animals; Anticonvulsants; Dapsone; Epilepsy; Fluorodeoxyglucose F18; Hippocampus; Kainic Acid; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2023 |
Kainic acid induced hyperexcitability in thalamic reticular nucleus that initiates an inflammatory response through the HMGB1/TLR4 pathway.
Topics: Epilepsy; HMGB1 Protein; Humans; Kainic Acid; NF-kappa B; Receptors, AMPA; Toll-Like Receptor 4 | 2023 |
LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Mice; Seizures | 2023 |
TMT-based proteomics profile reveals changes of the entorhinal cortex in a kainic acid model of epilepsy in mice.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Proteomics; Seizures; Tandem Mass Spectrometry | 2023 |
Long-term outcomes of classic and novel anti-seizure medication in a kainate-induced model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Temporal Lobe; Kainic Acid; Mice; Valproic Acid | 2023 |
Anticonvulsant Effects of Royal Jelly in Kainic Acid-Induced Animal Model of Temporal Lobe Epilepsy Through Antioxidant Activity.
Topics: Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar; Seizures | 2023 |
TGF-β Activated Kinase 1 (TAK1) Is Activated in Microglia After Experimental Epilepsy and Contributes to Epileptogenesis.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Kainic Acid; MAP Kinase Kinase Kinases; Mice; Mice, Transgenic; Microglia; Transforming Growth Factor beta | 2023 |
Adult-onset epilepsy and hippocampal pathology in a California sea lion (Zalophus californianus): A case study of suspected in utero exposure to domoic acid.
Topics: Animals; Epilepsy; Epileptic Syndromes; Hippocampus; Kainic Acid; Sea Lions | 2023 |
Pulsed Focused Ultrasound Reduces Hippocampal Volume Loss and Improves Behavioral Performance in the Kainic Acid Rat Model of Epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2023 |
GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy.
Topics: Animals; Apoptosis; Caspase 1; Caspase 3; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Phosphate-Binding Proteins; Pore Forming Cytotoxic Proteins; Pyroptosis; Seizures | 2023 |
CRISPR-Based KCC2 Upregulation Attenuates Drug-Resistant Seizure in Mouse Models of Epilepsy.
Topics: Animals; Calcium; Diazepam; Epilepsy; Hippocampus; Kainic Acid; Mice; Pharmaceutical Preparations; Symporters; Up-Regulation | 2023 |
Inflachromene attenuates seizure severity in mouse epilepsy models via inhibiting HMGB1 translocation.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; HMGB Proteins; HMGB1 Protein; Kainic Acid; Mice | 2023 |
Glycolysis inhibition partially resets epilepsy-induced alterations in the dorsal hippocampus-basolateral amygdala circuit involved in anxiety-like behavior.
Topics: Animals; Anxiety; Basolateral Nuclear Complex; Epilepsy; Epilepsy, Temporal Lobe; Glycolysis; Hippocampus; Kainic Acid | 2023 |
Neurofilament light chain: A possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy?
Topics: Animals; Biomarkers; Diazepam; Epilepsy; Intermediate Filaments; Kainic Acid; Ketamine; Mice; Neurofilament Proteins; Seizures | 2023 |
GKLF, a transcriptional activator of Txnip, drives microglia activation in kainic acid-induced murine models of epileptic seizures.
Topics: Animals; Carrier Proteins; Cytokines; Disease Models, Animal; Epilepsy; Inflammasomes; Kainic Acid; Kruppel-Like Factor 4; Lipopolysaccharides; Mice; Microglia; Neuroinflammatory Diseases; NLR Family, Pyrin Domain-Containing 3 Protein; Seizures; Thioredoxins; Transcription Factors | 2023 |
Astrocytic CD44 Deficiency Reduces the Severity of Kainate-Induced Epilepsy.
Topics: Animals; Astrocytes; Epilepsy; Hippocampus; Kainic Acid; Mice; Seizures | 2023 |
Principal neurons in the olfactory cortex mediate bidirectional modulation of seizures.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Mice; Neurons; Piriform Cortex; Seizures | 2023 |
Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Neurons; Oxidative Stress; Rats; Reactive Oxygen Species; Seizures; Sestrins; Status Epilepticus; Transcription Factors | 2023 |
Seizure-induced increase in microglial cell population in the developing zebrafish brain.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Microglia; Pentylenetetrazole; Seizures; Zebrafish | 2023 |
Sex and gonadectomy modify behavioral seizure susceptibility and mortality in a repeated low-dose kainic acid systemic injection paradigm in mice.
Topics: Animals; Castration; Epilepsy; Female; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Seizures; Status Epilepticus; Steroids | 2023 |
Morphological alterations of the neuronal Golgi apparatus upon seizures.
Topics: Adult; Animals; Epilepsy; Golgi Apparatus; Hippocampus; Humans; Kainic Acid; Neurons; Rats; Seizures | 2023 |
Dimethyl sulfoxide's impact on epileptiform activity in a mouse model of chronic temporal lobe epilepsy.
Topics: Animals; Dimethyl Sulfoxide; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Male; Mice; Solvents | 2023 |
Linking epileptic phenotypes and neural extracellular matrix remodeling signatures in mouse models of epilepsy.
Topics: Animals; Epilepsy; Extracellular Matrix; Kainic Acid; Mice; Neurons; Seizures | 2023 |
The role of subicular VIP-expressing interneurons on seizure dynamics in the intrahippocampal kainic acid model of temporal lobe epilepsy.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Interneurons; Kainic Acid; Seizures; Vasoactive Intestinal Peptide | 2023 |
Clinical signs and mortality of non-released stranded California sea lions housed in display facilities: the suspected role of prior exposure to algal toxins.
Topics: Animals; Animals, Zoo; Epilepsy; Kainic Acid; Marine Toxins; Sea Lions; Seizures; United States | 2019 |
Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Brain; Cognition; Epilepsy; Insulin; Kainic Acid; Male; Mice, Inbred C57BL; Pentylenetetrazole; Seizures | 2020 |
The GR-ANXA1 pathway is a pathological player and a candidate target in epilepsy.
Topics: Animals; Annexin A1; Blood Cell Count; Brain; Corticosterone; Epilepsy; Gene Expression Regulation; Hippocampus; Humans; Inflammation; Kainic Acid; Mice; Mice, Inbred C57BL; Receptors, Glucocorticoid | 2019 |
MicroRNA-542-3p Regulates P-glycoprotein Expression in Rat Epilepsy via the Toll-like Receptor 4/Nuclear Factor-kappaB Signaling Pathway.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Down-Regulation; Epilepsy; HEK293 Cells; Hippocampus; Humans; Kainic Acid; Male; MicroRNAs; NF-kappa B; Rats; Signal Transduction; Toll-Like Receptor 4 | 2019 |
MicroRNA-27a-3p Downregulation Inhibits Inflammatory Response and Hippocampal Neuronal Cell Apoptosis by Upregulating Mitogen-Activated Protein Kinase 4 (MAP2K4) Expression in Epilepsy: In Vivo and In Vitro Studies.
Topics: Animals; Apoptosis; Cell Survival; Disease Models, Animal; Down-Regulation; Epilepsy; Gene Expression Regulation; HEK293 Cells; Hippocampus; Humans; Inflammation; Kainic Acid; Male; MAP Kinase Kinase 4; MicroRNAs; Neurons; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2019 |
Aberrant expression of PAR bZIP transcription factors is associated with epileptogenesis, focus on hepatic leukemia factor.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Dentate Gyrus; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Kainic Acid; Male; Mice | 2020 |
Constitutive deletion of astrocytic connexins aggravates kainate-induced epilepsy.
Topics: Animals; Astrocytes; Connexins; Epilepsy; Gene Deletion; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic | 2020 |
Dexamethasone after early-life seizures attenuates increased susceptibility to seizures, seizure-induced microglia activation and neuronal injury later in life.
Topics: Animals; Dexamethasone; Disease Models, Animal; Epilepsy; Hippocampus; Inflammation; Kainic Acid; Macrophage Activation; Male; Microglia; Neurons; Rats, Long-Evans; Seizures | 2020 |
Epileptogenesis-induced changes of hippocampal-piriform connectivity.
Topics: Animals; Epilepsy; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2020 |
Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
Topics: Animals; Brain Chemistry; Cells, Cultured; Computational Biology; Cyclins; Epilepsy; Excitatory Amino Acid Agonists; Female; Genotype; Hippocampus; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurodegenerative Diseases; Reelin Protein; RNA-Seq | 2020 |
Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.
Topics: Animals; Chromosome Mapping; Collaborative Cross Mice; Convulsants; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Flurothyl; Gene Expression; Gene Expression Profiling; Genetic Predisposition to Disease; Genotype; Hippocampus; Kainic Acid; Mice; Mice, Inbred Strains; Pentylenetetrazole; Phenotype; Quantitative Trait Loci; Seizures; Sudden Unexpected Death in Epilepsy; Whole Genome Sequencing | 2020 |
Adipose-derived stem cell transplantation improves learning and memory via releasing neurotrophins in rat model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Learning; Male; Maze Learning; Memory; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Nerve Growth Factors; Neurons; Rats; Rats, Sprague-Dawley; Seizures | 2021 |
Osthole inhibits proliferation of kainic acid‑activated BV‑2 cells by modulating the Notch signaling pathway.
Topics: Animals; Cell Line, Transformed; Cell Proliferation; Cnidium; Coumarins; Drugs, Chinese Herbal; Epilepsy; Kainic Acid; Mice; Microglia; Receptors, Notch; Signal Transduction | 2020 |
CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures.
Topics: Adipocytes; Animals; Biotinylation; Cell Line; DNA-Binding Proteins; Epilepsy; Exosomes; Gene Expression Profiling; Gene Expression Regulation; Hippocampus; In Situ Hybridization, Fluorescence; Inflammation; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microglia; MicroRNAs; Oligonucleotide Array Sequence Analysis; RNA, Circular; RNA, Long Noncoding; Seizures; Signal Transduction; Suppressor of Cytokine Signaling Proteins | 2020 |
Combination therapy with dipeptidyl peptidase-4 and P2X7 purinoceptor inhibitors gives rise to antiepileptic effects in rats.
Topics: Animals; Anticonvulsants; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; DNA Fragmentation; Drug Therapy, Combination; Electroencephalography; Epilepsy; Gliosis; Hippocampus; Kainic Acid; Linagliptin; Male; Purinergic P2Y Receptor Antagonists; Rats; Rats, Wistar; Rosaniline Dyes; Seizures; Treatment Outcome | 2020 |
Dietary omega-3 fatty acids prevent neonatal seizure-induced early alterations in the hippocampal glutamatergic system and memory deficits in adulthood.
Topics: Animals; Diet; Epilepsy; Fatty Acids, Omega-3; Female; Glutamic Acid; Hippocampus; Kainic Acid; Male; Memory Disorders; Pregnancy; Rats; Rats, Wistar; Seizures | 2022 |
The complement C3-C3aR pathway mediates microglia-astrocyte interaction following status epilepticus.
Topics: Animals; Astrocytes; Complement C3; Epilepsy; Kainic Acid; Mice; Microglia; Status Epilepticus | 2021 |
Systematic evaluation of rationally chosen multitargeted drug combinations: a combination of low doses of levetiracetam, atorvastatin and ceftriaxone exerts antiepileptogenic effects in a mouse model of acquired epilepsy.
Topics: Animals; Anticonvulsants; Atorvastatin; Ceftriaxone; Drug Delivery Systems; Drug Evaluation, Preclinical; Drug Therapy, Combination; Electroencephalography; Epilepsy; Kainic Acid; Levetiracetam; Male; Mice; Treatment Outcome | 2021 |
Seizure activity and brain damage in a model of focal non-convulsive status epilepticus.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Disease Models, Animal; Epilepsy; Guinea Pigs; Kainic Acid; Seizures; Status Epilepticus | 2021 |
Indication of Dynamic Peroxynitrite Fluctuations in the Rat Epilepsy Model with a Near-Infrared Two-Photon Fluorescent Probe.
Topics: Animals; Cell Line; Cell Survival; Epilepsy; Fluorescent Dyes; Kainic Acid; Mice; Molecular Structure; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley | 2021 |
miR-128 regulates epilepsy sensitivity in mice by suppressing SNAP-25 and SYT1 expression in the hippocampus.
Topics: Animals; Down-Regulation; Epilepsy; Gene Knockdown Techniques; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; MicroRNAs; RNA, Messenger; Seizures; Status Epilepticus; Synaptic Transmission; Synaptosomal-Associated Protein 25; Synaptotagmin I | 2021 |
Neuroprotective Effects of Thymoquinone by the Modulation of ER Stress and Apoptotic Pathway in In Vitro Model of Excitotoxicity.
Topics: Animals; Apoptosis; Benzoquinones; CA3 Region, Hippocampal; Disease Models, Animal; Disks Large Homolog 4 Protein; Endoplasmic Reticulum Stress; Epilepsy; Excitatory Amino Acid Agonists; Female; In Vitro Techniques; Kainic Acid; Male; Neuronal Plasticity; Neuroprotective Agents; Rats; Rats, Wistar | 2021 |
Effects of scorpion venom heat-resistant peptide on the hippocampal neurons of kainic acid-induced epileptic rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Epilepsy; Hippocampus; Hot Temperature; Kainic Acid; Neurons; Peptides; Rats; Scorpion Venoms | 2021 |
LncRNA UCA1 alleviates aberrant hippocampal neurogenesis through regulating miR-375/SFRP1-mediated WNT/β-catenin pathway in kainic acid-induced epilepsy.
Topics: Animals; Cell Proliferation; Epilepsy; Genetic Vectors; HEK293 Cells; Hippocampus; Humans; Intracellular Signaling Peptides and Proteins; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; MicroRNAs; Neurogenesis; RNA, Long Noncoding; Wnt Signaling Pathway | 2021 |
Decreased excitatory drive onto hilar neuronal nitric oxide synthase expressing interneurons in chronic models of epilepsy.
Topics: Animals; Chronic Disease; Convulsants; Epilepsy; Excitatory Postsynaptic Potentials; Gene Expression Regulation, Enzymologic; Hippocampus; Humans; Interneurons; Kainic Acid; Male; Mice; Mice, Transgenic; Nitric Oxide Synthase Type I; Patch-Clamp Techniques; Pilocarpine; Rats, Sprague-Dawley | 2021 |
An optimized method for adult zebrafish brain-tissue dissociation that allows access mitochondrial function under healthy and epileptic conditions.
Topics: Animals; Brain; Cell Respiration; Disease Models, Animal; Energy Metabolism; Epilepsy; Female; Histocytological Preparation Techniques; Kainic Acid; Male; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Pentylenetetrazole; Tissue Preservation; Zebrafish | 2021 |
Cell death of hippocampal CA1 astrocytes during early epileptogenesis.
Topics: Animals; Astrocytes; Autophagy; CA1 Region, Hippocampal; Caspase 3; Cell Count; Cell Death; Cell Proliferation; Convulsants; Epilepsy; Kainic Acid; Male; Mice; Microglia; Protein Kinases; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Messenger; Status Epilepticus | 2021 |
Neuroprotective Effect of Ultrasound Neuromodulation on Kainic Acid- Induced Epilepsy in Mice.
Topics: Animals; Epilepsy; Kainic Acid; Mice; Neuroprotective Agents; Signal Transduction; Ultrasonic Waves | 2021 |
Vagus nerve stimulation affects inflammatory response and anti-apoptosis reactions via regulating miR-210 in epilepsy rat model.
Topics: Animals; Apoptosis; Disease Models, Animal; Epilepsy; Hippocampus; Inflammation; Kainic Acid; Male; MicroRNAs; Rats; Rats, Sprague-Dawley; Vagus Nerve Stimulation | 2021 |
Abnormal neuronal damage and inflammation in the hippocampus of kainic acid-induced epilepsy mice.
Topics: Animals; Disease Models, Animal; Doublecortin Protein; Epilepsy; Hippocampus; Inflammation; Kainic Acid; Mice; Mice, Inbred C57BL; Neurons | 2021 |
Microglia proliferation plays distinct roles in acquired epilepsy depending on disease stages.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Epilepsy; Hippocampus; Humans; Kainic Acid; Male; Mice; Microglia; Seizures; Status Epilepticus | 2021 |
Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice.
Topics: Amyloid beta-Protein Precursor; Animals; Cognitive Dysfunction; Electroencephalography; Epilepsy; Female; Glutamic Acid; Hippocampus; Homeostasis; Kainic Acid; Long-Term Potentiation; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Plaque, Amyloid; Presenilin-1 | 2021 |
Long-term electrical stimulation at ear and electro-acupuncture at ST36-ST37 attenuated COX-2 in the CA1 of hippocampus in kainic acid-induced epileptic seizure rats.
Topics: Acupuncture Points; Animals; Biomarkers; CA1 Region, Hippocampal; Chemokine CCL2; Cyclooxygenase 2; Electric Stimulation; Electroacupuncture; Epilepsy; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Kainic Acid; Male; Rats; Receptors, CCR2; S100 Calcium Binding Protein beta Subunit; Seizures; Time Factors | 2017 |
Foxp3 exhibits antiepileptic effects in ictogenesis involved in TLR4 signaling.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Cells, Cultured; Epilepsy; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Kainic Acid; Mice; Mice, Inbred BALB C; Mice, Knockout; Neuroglia; Neurons; Piperidines; Signal Transduction; Toll-Like Receptor 4 | 2017 |
The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Epilepsy; Humans; Kainic Acid; Male; Medication Adherence; Rats; Rats, Sprague-Dawley | 2017 |
Reorganization of the septohippocampal cholinergic fiber system in experimental epilepsy.
Topics: Analysis of Variance; Animals; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Wistar; Septum of Brain; Vesicular Acetylcholine Transport Proteins | 2017 |
DV21 decreases excitability of cortical pyramidal neurons and acts in epilepsy.
Topics: Action Potentials; Animals; Anthracenes; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Injections, Intraventricular; Kainic Acid; Mice, Inbred C57BL; Pentylenetetrazole; Pilocarpine; Pyramidal Cells; Severity of Illness Index; Triterpenes; Zebrafish | 2017 |
Neuroprotection of edaravone on the hippocampus of kainate-induced epilepsy rats through Nrf2/HO-1 pathway.
Topics: Animals; Edaravone; Epilepsy; Free Radical Scavengers; Heme Oxygenase-1; Hippocampus; Kainic Acid; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Random Allocation; Rats; Rats, Wistar; Signal Transduction | 2018 |
Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Epilepsy; Fenclonine; Hippocampus; Kainic Acid; Male; Maze Learning; Memory Disorders; Neurons; Rats, Wistar; Seizures; Serotonin; Spatial Memory | 2017 |
Alterations of apoptosis and autophagy in developing brain of rats with epilepsy: Changes in LC3, P62, Beclin-1 and Bcl-2 levels.
Topics: Animals; Apoptosis; Autophagy; Beclin-1; Epilepsy; Kainic Acid; Male; Microtubule-Associated Proteins; Neocortex; Neurons; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
PICK1 facilitates lasting reduction in GluA2 concentration in the hippocampus during chronic epilepsy.
Topics: Animals; Blotting, Western; Carrier Proteins; Chronic Disease; Cytoskeletal Proteins; Disease Models, Animal; Down-Regulation; Epilepsy; Hippocampus; Kainic Acid; Male; Multivariate Analysis; Neurons; Nuclear Proteins; Rats, Wistar; Receptors, AMPA; Regression Analysis; Tubulin | 2017 |
Anterior thalamic nuclei deep brain stimulation reduces disruption of the blood-brain barrier, albumin extravasation, inflammation and apoptosis in kainic acid-induced epileptic rats.
Topics: Albumins; Animals; Anterior Thalamic Nuclei; Apoptosis; Blood-Brain Barrier; Capillary Permeability; Deep Brain Stimulation; Disease Models, Animal; Epilepsy; Inflammation; Kainic Acid; Male; Random Allocation; Rats, Sprague-Dawley | 2017 |
A combination of NMDA and AMPA receptor antagonists retards granule cell dispersion and epileptogenesis in a model of acquired epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; Epilepsy; Humans; Kainic Acid; Male; Mice; Neurons; Piperidines; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Time Factors; Treatment Outcome | 2017 |
POSH participates in epileptogenesis by increasing the surface expression of the NMDA receptor: a promising therapeutic target for epilepsy.
Topics: Adolescent; Adult; Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; Gene Knockdown Techniques; Hippocampus; Humans; Kainic Acid; Lentivirus; Male; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Ubiquitin-Protein Ligases; Young Adult | 2017 |
d-Leucine: Evaluation in an epilepsy model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Kainic Acid; Leucine; Male; Mice; Photoperiod; Status Epilepticus | 2018 |
The gliadin peptide 31-43 exacerbates kainate neurotoxicity in epilepsy models.
Topics: Action Potentials; CA3 Region, Hippocampal; Celiac Disease; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Gliadin; Humans; Kainic Acid; Peptide Fragments; Transglutaminases | 2017 |
Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo.
Topics: Acetamides; Animals; Anticonvulsants; Behavior, Animal; Calcium Channels, R-Type; Electrocorticography; Epilepsy; Fructose; Genotype; Immunohistochemistry; Kainic Acid; Lacosamide; Lamotrigine; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Pyramidal Cells; Topiramate; Triazines | 2017 |
Disrupted Co-activation of Interneurons and Hippocampal Network after Focal Kainate Lesion.
Topics: Action Potentials; Animals; Cell Count; Cell Membrane; Cell Size; Disease Models, Animal; Electric Capacitance; Electric Impedance; Epilepsy; Green Fluorescent Proteins; Hippocampus; Interneurons; Kainic Acid; Male; Mice, Transgenic; Neural Pathways; Patch-Clamp Techniques; Tissue Culture Techniques | 2017 |
The role of S-nitrosylation of kainate-type of ionotropic glutamate receptor 2 in epilepsy induced by kainic acid.
Topics: Animals; Calcium; Disks Large Homolog 4 Protein; Epilepsy; GluK2 Kainate Receptor; Hippocampus; Kainic Acid; Male; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Primary Cell Culture; Rats, Sprague-Dawley; Receptors, Kainic Acid; Signal Transduction | 2018 |
Losartan suppresses the kainate-induced changes of angiotensin AT
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensins; Animals; Blood Pressure; Comorbidity; Disease Models, Animal; Epilepsy; Gene Expression; Hippocampus; Hypertension; Kainic Acid; Limbic System; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System | 2018 |
Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy.
Topics: Adult; Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy; Female; Growth Hormone-Releasing Hormone; Hippocampus; Humans; Kainic Acid; Male; Mice; Middle Aged; Neurons; Pentylenetetrazole; Receptors, GABA-A; Synapses; Young Adult | 2017 |
Favorable adverse effect profile of brivaracetam vs levetiracetam in a preclinical model.
Topics: Animals; Anticonvulsants; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Hippocampus; Humans; Kainic Acid; Levetiracetam; Male; Pyrrolidinones; Rats; Seizures; Synaptic Transmission | 2018 |
Intracerebroventricular administration of cigarette smoke condensate induced generalized seizures reduced by muscarinic receptor antagonist in rats.
Topics: Animals; Atropine; Convulsants; Epilepsy; Female; Kainic Acid; Male; Muscarinic Antagonists; Pregnancy; Rats; Receptors, Muscarinic; Seizures; Smoking | 2018 |
The pedunculopontine and laterodorsal tegmental nuclei in the kainate model of epilepsy.
Topics: Animals; Cell Count; Cholinergic Fibers; Cholinergic Neurons; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Neural Pathways; Pedunculopontine Tegmental Nucleus; Rats; Rats, Wistar; Tegmentum Mesencephali | 2018 |
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation; Glutathione; Kainic Acid; Kelch-Like ECH-Associated Protein 1; Male; Membrane Potential, Mitochondrial; Mice, Transgenic; Mutation; Neuroglia; Neurons; Oxidative Stress; Rats; Rats, Sprague-Dawley; Triterpenes | 2018 |
Effects of triptolide on the expression of MHC II in microglia in kainic acid‑induced epilepsy.
Topics: Animals; Diterpenes; Epilepsy; Epoxy Compounds; Gene Expression; Histocompatibility Antigens Class II; Immunohistochemistry; Kainic Acid; Microglia; Nuclear Proteins; Phenanthrenes; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; RNA, Messenger; Trans-Activators | 2018 |
MiR-181b inhibits P38/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid-induced epilepsy via targeting TLR4.
Topics: Animals; Apoptosis; Autophagy; Disease Models, Animal; Epilepsy; Female; Hippocampus; Kainic Acid; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; MicroRNAs; Neuroprotection; p38 Mitogen-Activated Protein Kinases; Random Allocation; Rats, Wistar; Toll-Like Receptor 4 | 2019 |
Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy.
Topics: Adenosine Triphosphate; Animals; Brain; Cerebral Cortex; Connexins; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mefloquine; Mice; Nerve Tissue Proteins; Probenecid; Seizures; Signal Transduction | 2018 |
MiR-134 expression and changes in inflammatory cytokines of rats with epileptic seizures.
Topics: Animals; Brain; Cell Proliferation; Cytokines; Epilepsy; Hippocampus; Inflammation; Kainic Acid; Male; MicroRNAs; Neurons; Rats; Seizures | 2018 |
Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Female; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Seizures | 2018 |
Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Mice, Inbred C57BL; Neurons; Seizures | 2018 |
Anterior nucleus of thalamus stimulation inhibited abnormal mossy fiber sprouting in kainic acid-induced epileptic rats.
Topics: Animals; Anterior Thalamic Nuclei; Cell Nucleus; Deep Brain Stimulation; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; GAP-43 Protein; Hippocampus; Kainic Acid; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Seizures; Semaphorin-3A | 2018 |
Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model.
Topics: Animals; Anti-Inflammatory Agents; Cognition Disorders; Curcumin; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Female; Hippocampus; Inflammation; Interleukin-1beta; Kainic Acid; Male; Maze Learning; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley | 2018 |
Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity.
Topics: Animals; Astrocytes; Calcium Signaling; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Inositol 1,4,5-Trisphosphate Receptors; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Knockout; Neurons; Seizures | 2018 |
Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms.
Topics: Anacardic Acids; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Electroshock; Epilepsy; Humans; Kainic Acid; Mice; Pentylenetetrazole; Pilocarpine; Saccharomyces cerevisiae | 2018 |
Echinacoside, an Active Constituent of Cistanche Herba, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway.
Topics: Animals; Brain; Cistanche; Cytokines; Disease Models, Animal; Epilepsy; Glutamic Acid; Glycogen Synthase Kinase 3 beta; Glycosides; Inflammation; Kainic Acid; Male; Microglia; Neuroprotective Agents; Neurotoxicity Syndromes; Phosphorylation; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Seizures; Signal Transduction | 2018 |
The Widespread Network Effects of Focal Epilepsy.
Topics: Animals; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Kainic Acid; Mice | 2018 |
n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis.
Topics: Animals; Anticonvulsants; Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; CD11b Antigen; Cytokines; Dinoprostone; Disease Models, Animal; Docosahexaenoic Acids; Encephalitis; Epilepsy; Gene Expression Regulation; Hippocampus; Kainic Acid; Leukotriene B4; Lipid Metabolism; Lipoxins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic | 2018 |
Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Kainic Acid; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin | 2018 |
The Epigenetic Factor CBP Is Required for the Differentiation and Function of Medial Ganglionic Eminence-Derived Interneurons.
Topics: Action Potentials; Animals; Anxiety; Behavior, Animal; Cell Differentiation; Chromosome Mapping; Cognition Disorders; Epigenesis, Genetic; Epilepsy; Female; Hippocampus; Interneurons; Kainic Acid; Learning; Male; Median Eminence; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Parvalbumins; Phosphoproteins; Somatostatin; Thyroid Nuclear Factor 1 | 2019 |
Acid reflux induced laryngospasm as a potential mechanism of sudden death in epilepsy.
Topics: Animals; Death, Sudden; Disease Models, Animal; Epilepsy; Esophagus; Female; Gastroesophageal Reflux; Hydrogen-Ion Concentration; Kainic Acid; Laryngismus; Rats, Long-Evans; Respiration; Seizures | 2018 |
A predictive epilepsy index based on probabilistic classification of interictal spike waveforms.
Topics: Action Potentials; Animals; Automation; Diagnosis, Computer-Assisted; Disease Models, Animal; Electroencephalography; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Models, Statistical; Neurophysiological Monitoring; Normal Distribution; Principal Component Analysis; Wavelet Analysis | 2018 |
[Induction of Epileptic Seizures in Mouse Models of Chronic Restraint Stress].
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Random Allocation; Restraint, Physical; Seizures; Stress, Psychological | 2018 |
GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylation.
Topics: Adolescent; Adult; Animals; Cells, Cultured; Child; Child, Preschool; Disease Models, Animal; Electroencephalography; Epilepsy; Female; Glycogen Synthase Kinase 3 beta; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Kainic Acid; Male; Mice; Mice, Transgenic; Middle Aged; Muscle Proteins; Phosphorylation; Potassium Channels; Receptors, AMPA; Signal Transduction; Synaptic Transmission; Video Recording | 2019 |
Neuronal protective effect of Songling Xuemaikang capsules alone and in combination with carbamazepine on epilepsy in kainic acid-kindled rats.
Topics: Animals; Anticonvulsants; Apoptosis; Carbamazepine; Caspase 9; Cognition; Drug Therapy, Combination; Drugs, Chinese Herbal; Epilepsy; Hippocampus; Kainic Acid; Male; Maze Learning; Proto-Oncogene Proteins c-akt; Random Allocation; Rats; Seizures | 2019 |
Expression of nuclear factor-erythroid 2-related factor 2 in rat brain following the administration of kainic acid and pentylenetetrazole.
Topics: Animals; Brain; Convulsants; Epilepsy; Kainic Acid; Male; NF-E2-Related Factor 2; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Wistar | 2019 |
Effect of carbamazepine on spontaneous recurrent seizures recorded from the dentate gyrus in rats with kainate-induced epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Convulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Recurrence; Seizures | 2019 |
[An Improved Method for Electroencephalographic Detection of Epileptic Discharge].
Topics: Animals; Electroencephalography; Epilepsy; Kainic Acid; Mice; Mice, Inbred C57BL; Seizures | 2019 |
Antioxidant treatment after epileptogenesis onset prevents comorbidities in rats sensitized by a past stressful event.
Topics: Animals; Antioxidants; Behavior, Animal; Comorbidity; Convulsants; Cyclic N-Oxides; Epilepsy; Kainic Acid; Psychological Distress; Rats; Spin Labels; Status Epilepticus | 2019 |
ALG13 Deficiency Associated with Increased Seizure Susceptibility and Severity.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Mice; Mice, Knockout; N-Acetylglucosaminyltransferases; Neurons; Seizures; Severity of Illness Index; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Stereotypical patterns of epileptiform calcium signal in hippocampal CA1, CA3, dentate gyrus and entorhinal cortex in freely moving mice.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Calcium; Dentate Gyrus; Entorhinal Cortex; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Optical Fibers; Photometry; Stereotyped Behavior | 2019 |
Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis.
Topics: Animals; Behavior, Animal; Epilepsy; Inositol; Kainic Acid; Seizures; Time Factors | 2019 |
Establishment of a novel mesial temporal lobe epilepsy rhesus monkey model via intra-hippocampal and intra-amygdala kainic acid injection assisted by neurosurgical robot system.
Topics: Amygdala; Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Functional Laterality; Gyrus Cinguli; Hippocampus; Kainic Acid; Macaca mulatta; Magnetic Resonance Imaging; Male; Neurons; Neurosurgical Procedures; Robotic Surgical Procedures; Robotics; Seizures; Temporal Lobe | 2019 |
P2Y4/TSP-1/TGF-β1/pSmad2/3 pathway contributes to acute generalized seizures induced by kainic acid.
Topics: Angiogenesis Modulating Agents; Animals; Blood-Brain Barrier; Cells, Cultured; Epilepsy; Kainic Acid; Male; Neovascularization, Physiologic; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Seizures; Signal Transduction; Smad2 Protein; Smad3 Protein; Thrombospondin 1; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2019 |
Partial depletion of septohippocampal cholinergic cells reduces seizure susceptibility, but does not mitigate hippocampal neurodegeneration in the kainate model of epilepsy.
Topics: Animals; Cholinergic Agents; Cholinergic Neurons; Disease Susceptibility; Epilepsy; Hippocampus; Kainic Acid; Male; Neurons; Non-Neuronal Cholinergic System; Rats; Rats, Wistar; Saporins; Seizures; Status Epilepticus; Temporal Lobe | 2019 |
Neuroprotective and anti-inflammatory effects of isoliquiritigenin in kainic acid-induced epileptic rats via the TLR4/MYD88 signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; bcl-2-Associated X Protein; Chalcones; Cytokines; Epilepsy; Hippocampus; Kainic Acid; Microglia; Myeloid Differentiation Factor 88; Neuroprotective Agents; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4 | 2019 |
The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis.
Topics: Amidines; Animals; Anticonvulsants; Benzylamines; Epilepsy; Hippocampus; Kainic Acid; Male; Mice, Inbred C57BL; Nitric Oxide Synthase Type II; Peptides; Proteomics; Status Epilepticus | 2019 |
Epileptiform activity contralateral to unilateral hippocampal sclerosis does not cause the expression of brain damage markers.
Topics: Animals; Biomarkers; Brain Injuries; CA1 Region, Hippocampal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Guinea Pigs; Hippocampus; Kainic Acid; Magnetic Resonance Imaging; Male; Nerve Tissue Proteins; Sclerosis; Status Epilepticus | 2019 |
Expression of brain-derived neurotrophic factor and structural plasticity in the dentate gyrus and CA2 region correlate with epileptiform activity.
Topics: Animals; Brain-Derived Neurotrophic Factor; CA3 Region, Hippocampal; Dentate Gyrus; Electrocorticography; Electrodes, Implanted; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neuropeptide Y; Status Epilepticus; Up-Regulation | 2019 |
Involvement of monocarboxylate transporters in the cross-tolerance between epilepsy and cerebral infarction: A promising choice towards new treatments.
Topics: Animals; Antigens, Nuclear; Cerebral Infarction; Epilepsy; Glial Fibrillary Acidic Protein; Hippocampus; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Kainic Acid; Lactic Acid; Male; Monocarboxylic Acid Transporters; Muscle Proteins; Nerve Tissue Proteins; Rats, Sprague-Dawley; Symporters | 2019 |
Comparison of kainate-induced seizures, cognitive impairment and hippocampal damage in male and female mice.
Topics: Animals; Astrocytes; Cognitive Dysfunction; Disease Models, Animal; Epilepsy; Female; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Microglia; Neurons; Seizures; Sex Factors | 2019 |
Altered serotonin innervation in the rat epileptic brain.
Topics: Animals; Brain Stem; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Prosencephalon; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2019 |
MicroRNA-23a contributes to hippocampal neuronal injuries and spatial memory impairment in an experimental model of temporal lobe epilepsy.
Topics: Animals; Antagomirs; Brain; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Memory Disorders; Mice; Mice, Inbred C57BL; MicroRNAs; Neurons; Spatial Memory; Status Epilepticus; Temporal Lobe | 2019 |
Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy.
Topics: Animals; Antioxidants; Biomarkers; Chronic Disease; Epilepsy; Kainic Acid; Leprostatic Agents; Male; NADPH Oxidases; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Reactive Oxygen Species | 2019 |
Changes in brain cortex sensitivity to epileptogens under conditions of ketogenic diet.
Topics: Animals; Cerebral Cortex; Diet, Ketogenic; Epilepsy; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Penicillin G; Rats; Rats, Wistar; Strychnine | 2013 |
Epilepsy-induced motility of differentiated neurons.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Cell Body; Cell Movement; Dendrites; Disease Models, Animal; Epilepsy; Extracellular Matrix Proteins; Green Fluorescent Proteins; Immunohistochemistry; In Situ Hybridization; Interneurons; Kainic Acid; Male; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Nerve Tissue Proteins; Neurogenesis; Neurons; Patch-Clamp Techniques; Reelin Protein; RNA, Messenger; Serine Endopeptidases; Tissue Culture Techniques | 2014 |
The PI3K/Akt and ERK1/2 signaling pathways mediate the erythropoietin-modulated calcium influx in kainic acid-induced epilepsy.
Topics: Animals; Blotting, Western; CA3 Region, Hippocampal; Calcium; Cells, Cultured; Electrophysiological Phenomena; Epilepsy; Erythropoietin; Evoked Potentials; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; MAP Kinase Signaling System; Neurons; Oncogene Protein v-akt; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Recombinant Proteins; Signal Transduction; Transfection | 2013 |
The effect of kainic acid on hippocampal dendritic spine motility at the early and late stages of brain development.
Topics: Animals; Brain; CA1 Region, Hippocampal; Dendritic Spines; Disease Models, Animal; Epilepsy; Kainic Acid; Locomotion; Mice; Mice, Transgenic; Time-Lapse Imaging | 2013 |
Status epilepticus alters neurogenesis and decreases the number of GABAergic neurons in the septal dentate gyrus of 9-day-old rats at the early phase of epileptogenesis.
Topics: Animals; Animals, Newborn; Bromodeoxyuridine; Cell Count; Dentate Gyrus; Disease Models, Animal; Doublecortin Protein; Epilepsy; Excitatory Amino Acid Agonists; GABAergic Neurons; Gene Expression Regulation; Glutamate Decarboxylase; Kainic Acid; Nerve Tissue Proteins; Neurogenesis; Parvalbumins; Rats; Receptors, GABA-A | 2013 |
[The effects of low-frequency electric stimulus on hippocampal of Effects of low-frequency electric stimulus on hippocampal of α5 subunit of extra synapse GABAA receptor in kainic acid-induced epilepsy rats].
Topics: Animals; Electric Stimulation; Epilepsy; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2013 |
EPAC inhibition of SUR1 receptor increases glutamate release and seizure vulnerability.
Topics: Animals; Bicuculline; Biophysics; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Glutamic Acid; Guanine Nucleotide Exchange Factors; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Kainic Acid; KATP Channels; Male; Membrane Potentials; Mice; Mice, Knockout; Patch-Clamp Techniques; Probability; Protein Binding; Quinoxalines; Synaptosomes; Transduction, Genetic | 2013 |
Expression of sodium channel α subunits 1.1, 1.2 and 1.6 in rat hippocampus after kainic acid-induced epilepsy.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Convulsants; Data Interpretation, Statistical; Electrodes, Implanted; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Hippocampus; Immunohistochemistry; Interneurons; Kainic Acid; Male; NAV1.1 Voltage-Gated Sodium Channel; NAV1.2 Voltage-Gated Sodium Channel; NAV1.6 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2013 |
Prenatal transport stress, postnatal maternal behavior, and offspring sex differentially affect seizure susceptibility in young rats.
Topics: Animals; Animals, Newborn; Brain; Corticosterone; Disease Models, Animal; Disease Susceptibility; Epilepsy; Excitatory Amino Acid Agonists; Female; Kainic Acid; Lipopolysaccharides; Male; Maternal Behavior; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Sex Characteristics; Stress, Psychological; Time Factors | 2013 |
Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Carrier Proteins; Cells, Cultured; Disease Models, Animal; Epilepsy; Fluorine Radioisotopes; Immunoenzyme Techniques; Inflammation; Kainic Acid; Macrophages; Male; Mice; Mice, Inbred C57BL; Microglia; Positron-Emission Tomography; Pyrazoles; Pyrimidines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Stroke | 2013 |
DNA methylation mediates persistent epileptiform activity in vitro and in vivo.
Topics: 5' Flanking Region; Animals; Cell Line; CpG Islands; DNA Methylation; Epilepsy; Gene Order; Genetic Association Studies; Hippocampus; Humans; Kainic Acid; Male; Membrane Potentials; Mice; Neurons; Phenotype; Phthalimides; Promoter Regions, Genetic; Rats; Receptors, AMPA; Seizures; Tryptophan | 2013 |
Modulation of cortical synchrony by vagus nerve stimulation in adult rats.
Topics: Animals; Cortical Synchronization; Epilepsy; Image Processing, Computer-Assisted; Kainic Acid; Male; Microelectrodes; Rats; Rats, Wistar; Temporal Lobe; Vagus Nerve Stimulation | 2013 |
Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid.
Topics: Animals; Astrocytes; Caspase 3; Epilepsy; Hippocampus; Immunohistochemistry; Infusions, Intraventricular; Kainic Acid; Male; Mice; Microglia; Neurogenesis; Neuronal Plasticity | 2013 |
[Expression of growth-associated protein 43 in the hippocampus of mesial temporal lobe epilepsy mouse model].
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; GAP-43 Protein; Hippocampus; Kainic Acid; Mice; Seizures | 2013 |
[Comparison of seizure induced by different drugs in ICR Mice].
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Pilocarpine | 2013 |
Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease.
Topics: Animals; Autophagy; Biomarkers; Disease Models, Animal; Dual-Specificity Phosphatases; Electrical Synapses; Epilepsy; Glycogen; Glycogen Synthase; Hippocampus; Humans; Inclusion Bodies; Kainic Acid; Lafora Disease; Mice; Mice, Knockout; Mutation; Protein Tyrosine Phosphatases, Non-Receptor; Ubiquitin-Protein Ligases | 2014 |
Uncaria rhynchophylla and rhynchophylline improved kainic acid-induced epileptic seizures via IL-1β and brain-derived neurotrophic factor.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Epilepsy; Gene Expression; Indole Alkaloids; Interleukin-1beta; Kainic Acid; Male; Oxindoles; Phytotherapy; Plant Extracts; Rats, Sprague-Dawley; Toll-Like Receptors; Uncaria | 2014 |
Hippocampal neuropathology of domoic acid-induced epilepsy in California sea lions (Zalophus californianus).
Topics: Age Factors; Animals; Cell Count; Chronic Disease; Epilepsy; Epilepsy, Temporal Lobe; Female; Functional Laterality; Hippocampus; Humans; Kainic Acid; Male; Marine Toxins; Neurons; Organ Size; Sclerosis; Sea Lions; Sex Factors; Somatostatin; Species Specificity | 2014 |
Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; CD11b Antigen; Cell Death; Disease Models, Animal; Epilepsy; Ganglia, Spinal; Gene Expression Regulation; Gliosis; Hippocampus; Kainic Acid; Ligation; Male; Microtubule-Associated Proteins; Neuralgia; Neurotoxins; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Tetanus Toxin | 2014 |
Cardiac phenomena during kainic-acid induced epilepsy and lamotrigine antiepileptic therapy.
Topics: Animals; Anticonvulsants; Death, Sudden; Electrocardiography; Epilepsy; Kainic Acid; Lamotrigine; Mice; Risk Factors; Tachycardia; Triazines | 2014 |
Reciprocal changes in phosphorylation and methylation of mammalian brain sodium channels in response to seizures.
Topics: Action Potentials; Animals; Arginine; Brain; Cell Line; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Kidney; Male; Mass Spectrometry; Methylation; NAV1.2 Voltage-Gated Sodium Channel; Phosphorylation; Proteomics; Rats | 2014 |
[Effects of low-frequency electrical stimulation of hippocampus on the expression of GABAA receptor α1 and β2 subunits in kainate-kindled rats].
Topics: Animals; Electric Stimulation; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synapses | 2014 |
A subconvulsive dose of kainate selectively compromises astrocytic metabolism in the mouse brain in vivo.
Topics: Animals; Astrocytes; Brain; Citric Acid Cycle; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Glutamine; Kainic Acid; Lactates; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL | 2014 |
Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Biophysics; Carbamazepine; Convulsants; Disease Models, Animal; Electric Stimulation; Epilepsy; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Kainic Acid; Membrane Potentials; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pilocarpine; Rats; Rats, Wistar; Sodium Channels | 2014 |
Electroacupuncture at ST36-ST37 and at ear ameliorates hippocampal mossy fiber sprouting in kainic acid-induced epileptic seizure rats.
Topics: Acupuncture, Ear; Animals; Electroacupuncture; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kainic Acid; Mossy Fibers, Hippocampal; Neurons; Rats | 2014 |
Auricular electroacupuncture reduced inflammation-related epilepsy accompanied by altered TRPA1, pPKCα, pPKCε, and pERk1/2 signaling pathways in kainic acid-treated rats.
Topics: Animals; Electroacupuncture; Epilepsy; Inflammation; Kainic Acid; Male; MAP Kinase Signaling System; Protein Kinase C-alpha; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Signal Transduction; TRPA1 Cation Channel; TRPC Cation Channels | 2014 |
[Effects of hippocampal stimulus on α₅ subunit of extrasynaptic GABA(A) receptor in kainic acid-induced epileptic rats].
Topics: Animals; Electric Stimulation; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2014 |
Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation.
Topics: Age Factors; Amines; Animals; Animals, Newborn; Anticonvulsants; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electric Stimulation; Epilepsy; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Freezing; Gabapentin; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamic Acid; In Vitro Techniques; Kainic Acid; Malformations of Cortical Development; Mice; Mice, Inbred C57BL; Neuroimaging; Patch-Clamp Techniques; Somatosensory Cortex; Thrombospondins | 2014 |
Kainate-induced epileptogenesis alters circular hole board learning strategy but not the performance of C57BL/6J mice.
Topics: Animals; Anxiety; Cognition; Convulsants; Epilepsy; Hippocampus; Kainic Acid; Learning; Male; Maze Learning; Mice; Mice, Inbred C57BL; Psychomotor Performance; Recognition, Psychology; Space Perception | 2014 |
Cholesterol metabolite cholestane-3β,5α,6β-triol suppresses epileptic seizures by negative modulation of voltage-gated sodium channels.
Topics: Animals; Anticonvulsants; Cholestanols; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels | 2015 |
Adult Deletion of SRF Increases Epileptogenesis and Decreases Activity-Induced Gene Expression.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Epilepsy; GADD45 Proteins; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Hippocampus; Intracellular Signaling Peptides and Proteins; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Serum Response Factor; Tristetraprolin | 2016 |
CXCR4 Antagonist AMD3100 Suppresses the Long-Term Abnormal Structural Changes of Newborn Neurons in the Intraventricular Kainic Acid Model of Epilepsy.
Topics: Animals; Animals, Newborn; Benzylamines; Cyclams; Dendrites; Doublecortin Protein; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy; Heterocyclic Compounds; Hippocampus; Infusions, Intraventricular; Kainic Acid; Male; Maze Learning; Mice; Mossy Fibers, Hippocampal; Neurogenesis; Random Allocation; Rats, Wistar; Receptors, CXCR4 | 2016 |
A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Knockout; Microglia; Neurons; Peptides, Cyclic; Pilocarpine; Receptor, Anaphylatoxin C5a; Seizures; Tumor Necrosis Factor-alpha | 2015 |
Key proteins of activating cell death can be predicted through a kainic acid-induced excitotoxic stress.
Topics: Animals; Apoptosis; Biomarkers; Cell Death; Epilepsy; Kainic Acid; Necrosis; Neurons; Proteome; Proteomics; Rats; Rats, Sprague-Dawley; Seizures; Stress, Physiological | 2015 |
Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy.
Topics: Animals; Autoantigens; Blotting, Western; Cell Adhesion Molecules, Neuronal; Cell Survival; Cells, Cultured; Endoplasmic Reticulum; Epilepsy; Extracellular Matrix Proteins; Fluorescent Antibody Technique; Fructose; Golgi Apparatus; Kainic Acid; Lysosomes; Membrane Proteins; Mitochondria; Models, Biological; Nerve Tissue Proteins; Neurons; Protein Processing, Post-Translational; Proteolysis; Rats; Reelin Protein; Serine Endopeptidases; Topiramate | 2016 |
Ceruloplasmin is an endogenous protectant against kainate neurotoxicity.
Topics: Adolescent; Adult; Animals; CA1 Region, Hippocampal; Case-Control Studies; Ceruloplasmin; Epilepsy; Female; Glutathione; Humans; Hydroxyl Radical; Kainic Acid; Lipid Peroxidation; Male; Middle Aged; Oxidative Stress; Rats, Sprague-Dawley; Young Adult | 2015 |
Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models.
Topics: Analysis of Variance; Animals; Arginase; beta-N-Acetylhexosaminidases; Convulsants; Cytokines; Disease Models, Animal; Epilepsy; Flow Cytometry; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Lectins; Male; Mice; Microglia; Pilocarpine; Time Factors | 2015 |
Predicting and treating stress-induced vulnerability to epilepsy and depression.
Topics: Allostasis; Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Depression; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Flavones; Hypothalamo-Hypophyseal System; Kainic Acid; Male; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Social Environment; Status Epilepticus; Stress, Psychological | 2015 |
[Peculiarities of neurodegeneration in hippocampus fields after kainic acid action in rats].
Topics: Animals; Apoptosis; Benzoxazines; Cerebral Ventricles; Epilepsy; Fluoresceins; GluK2 Kainate Receptor; Hippocampus; Injections, Intraventricular; Kainic Acid; Male; Microscopy, Fluorescence; Neurons; Organ Specificity; Rats; Rats, Wistar; Receptors, Kainic Acid | 2014 |
Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis.
Topics: Adult; Animals; Astrocytes; Cells, Cultured; Disease Models, Animal; Epilepsy; Hippocampus; Humans; Kainic Acid; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Psychomotor Agitation | 2015 |
Maternal immune activation increases seizure susceptibility in juvenile rat offspring.
Topics: Animals; Animals, Newborn; Anxiety; Brain Injuries; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Hippocampus; Kainic Acid; Lipopolysaccharides; Male; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Seizures | 2015 |
Emodin plays an interventional role in epileptic rats via multidrug resistance gene 1 (MDR1).
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Behavior, Animal; Brain; Brain Waves; Cyclooxygenase 2; Disease Models, Animal; Electroencephalography; Emodin; Epilepsy; Female; Kainic Acid; Microscopy, Confocal; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation | 2015 |
Cytokine-dependent bidirectional connection between impaired social behavior and susceptibility to seizures associated with maternal immune activation in mice.
Topics: Animals; Autistic Disorder; Cytokines; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Hippocampus; Interleukin-1beta; Interleukin-6; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Pregnancy; Seizures; Status Epilepticus | 2015 |
MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.
Topics: Animals; Caspase 3; Cytochromes c; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Kainic Acid; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Mitochondria; Neural Stem Cells; Neurogenesis; Protein Isoforms; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2015 |
Expression level and distribution of HMGB1 in Sombati's cell model and kainic acid-induced epilepsy model.
Topics: Animals; Animals, Newborn; Cells, Cultured; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Hippocampus; HMGB1 Protein; Kainic Acid; Male; Mice; Neurons; Rats; Rats, Sprague-Dawley | 2015 |
Metallothionein expression in the rat brain following KA and PTZ treatment.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Metallothionein; Oxidative Stress; Pentylenetetrazole; Rats; Rats, Wistar; Tyrosine | 2015 |
Brain inflammation in a chronic epilepsy model: Evolving pattern of the translocator protein during epileptogenesis.
Topics: Animals; Autoradiography; Brain; Carrier Proteins; Chronic Disease; Disease Models, Animal; Disease Progression; Electrocorticography; Encephalitis; Epilepsy; Follow-Up Studies; Immunohistochemistry; Kainic Acid; Longitudinal Studies; Magnetic Resonance Imaging; Male; Nerve Degeneration; Neuroglia; Neurons; Positron-Emission Tomography; Rats, Wistar; Receptors, GABA-A | 2015 |
Altered taste preference and loss of limbic-projecting serotonergic neurons in the dorsal raphe nucleus of chronically epileptic rats.
Topics: Anhedonia; Animals; Cell Count; Chronic Disease; Depressive Disorder; Disease Models, Animal; Dorsal Raphe Nucleus; Electrocorticography; Epilepsy; Immunohistochemistry; Kainic Acid; Male; Random Allocation; Rats, Wistar; Seizures; Serotonergic Neurons; Status Epilepticus; Taste Perception | 2016 |
HMGB1 Contributes to the Expression of P-Glycoprotein in Mouse Epileptic Brain through Toll-Like Receptor 4 and Receptor for Advanced Glycation End Products.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Disease Models, Animal; Epilepsy; HMGB1 Protein; Kainic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Receptor for Advanced Glycation End Products; Toll-Like Receptor 4 | 2015 |
Low-frequency stimulation in anterior nucleus of thalamus alleviates kainate-induced chronic epilepsy and modulates the hippocampal EEG rhythm.
Topics: Animals; Anterior Thalamic Nuclei; Deep Brain Stimulation; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL | 2016 |
Comparative power spectrum analysis of EEG activity in spontaneously hypertensive and Wistar rats in kainate model of temporal model of epilepsy.
Topics: Animals; Blood Pressure; Brain Mapping; Brain Waves; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Spectrum Analysis | 2016 |
Stimulation of Anterior Thalamic Nuclei Protects Against Seizures and Neuronal Apoptosis in Hippocampal CA3 Region of Kainic Acid-induced Epileptic Rats.
Topics: Animals; Anterior Thalamic Nuclei; Apoptosis; Deep Brain Stimulation; Epilepsy; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures | 2016 |
Regulation of astrocyte glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) expression in a model of epilepsy.
Topics: Analysis of Variance; Animals; Aquaporin 4; Astrocytes; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Functional Laterality; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; RNA, Messenger; Time Factors | 2016 |
Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Kindling, Neurologic; Magnetic Resonance Imaging; Male; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Wistar; Selenic Acid; tau Proteins | 2016 |
Exploratory Metabolomics Profiling in the Kainic Acid Rat Model Reveals Depletion of 25-Hydroxyvitamin D3 during Epileptogenesis.
Topics: Animals; Biomarkers; Calcifediol; Chromatography, Liquid; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Mass Spectrometry; Metabolomics; Pilot Projects; Plasma; Rats | 2016 |
Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death.
Topics: Animals; Calcium; Calcium Channel Agonists; Cell Death; Cells, Cultured; Disease Models, Animal; Epilepsy; Humans; Kainic Acid; Male; Mice; Mice, Knockout; Mitochondria; Neurons; Nitric Oxide; Pyramidal Cells; Ryanodine Receptor Calcium Release Channel | 2016 |
Neonatal domoic acid alters in vivo binding of [
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Animals, Newborn; Brain; Carbon Radioisotopes; Epilepsy; Hippocampus; Hypothalamus; Kainic Acid; Male; Neuromuscular Depolarizing Agents; Positron-Emission Tomography; Prefrontal Cortex; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Yohimbine | 2016 |
Dynamic causal modelling of seizure activity in a rat model.
Topics: Animals; Bayes Theorem; Epilepsy; Hippocampus; Kainic Acid; Models, Neurological; Neurons; Rats, Wistar; Seizures; Signal Processing, Computer-Assisted | 2017 |
Superimposing Status Epilepticus on Neuron Subset-Specific PTEN Haploinsufficient and Wild Type Mice Results in Long-term Changes in Behavior.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Epilepsy; Haploinsufficiency; Kainic Acid; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mutation; Neurons; PTEN Phosphohydrolase; Seizures; Social Behavior; Status Epilepticus | 2016 |
Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry.
Topics: Animals; Brain; Epilepsy; Fatty Acids; Heart; Kainic Acid; Lipids; Lung; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Signal Transduction | 2017 |
Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Carbamazepine; Cyanobacteria; Dipeptides; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Lipopolysaccharides; Male; Mice, Inbred C57BL; MicroRNAs; Oligonucleotides; para-Aminobenzoates; Random Allocation; Receptors, Interleukin-1 Type I; Time Factors; Toll-Like Receptor 4 | 2017 |
Deep brain stimulation of the anterior nucleus of the thalamus reverses the gene expression of cytokines and their receptors as well as neuronal degeneration in epileptic rats.
Topics: Animals; Anterior Thalamic Nuclei; Cytokines; Deep Brain Stimulation; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression; Kainic Acid; Male; Microscopy, Electron, Transmission; Neurodegenerative Diseases; Random Allocation; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Cytokine | 2017 |
Therapeutic potential of an anti-high mobility group box-1 monoclonal antibody in epilepsy.
Topics: Animals; Antibodies, Monoclonal; Anticonvulsants; Brain; Epilepsy; HMGB1 Protein; Humans; Kainic Acid; Mice, Inbred C57BL; Mice, Knockout; Toll-Like Receptor 4 | 2017 |
Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Epilepsy; Gene Expression; Kainic Acid; Male; NF-kappa B; Pregnane X Receptor; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Steroid; Up-Regulation | 2017 |
Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity.
Topics: Adult; Animals; Apoptosis; Convulsants; Cyclin D1; Disease Models, Animal; Epilepsy; Female; Hippocampus; Humans; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurotoxins; Pentylenetetrazole; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2008 |
The effect of the ketogenic diet on hippocampal GluR5 and Glu(6 mRNA expression and Q/R site editing in the kainate-induced epilepsy model.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Base Sequence; Behavior, Animal; Body Weight; Diet, Ketogenic; Disease Models, Animal; Epilepsy; Gene Expression; GluK2 Kainate Receptor; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; RNA Editing; RNA, Messenger | 2008 |
Epileptiform activities in slices of hippocampus from mice after intra-hippocampal injection of kainic acid.
Topics: Action Potentials; Animals; Biological Clocks; Epilepsy; Hippocampus; Injections; Kainic Acid; Male; Mice | 2008 |
Dynamics of evoked local field potentials in the hippocampus of epileptic rats with spontaneous seizures.
Topics: Analysis of Variance; Animals; Biophysics; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Potentials; Excitatory Postsynaptic Potentials; Hippocampus; Kainic Acid; Male; Nonlinear Dynamics; Rats; Rats, Sprague-Dawley; Seizures; Time Factors | 2009 |
NMDA receptor-mediated long-term alterations in epileptiform activity in experimental chronic epilepsy.
Topics: Analysis of Variance; Animals; Biphenyl Compounds; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Synaptic Depression; Male; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Wakefulness | 2009 |
Changes in oscillatory activity of neurons in the medial septal area in animals with a model of chronic temporal epilepsy.
Topics: Action Potentials; Animals; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Guinea Pigs; Kainic Acid; Neurons; Periodicity; Septum of Brain; Time Factors | 2008 |
Prevention of epilepsy by taurine treatments in mice experimental model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Calpain; Cell Death; Chromatography, High Pressure Liquid; Disease Models, Animal; Epilepsy; Immunoblotting; Immunohistochemistry; Injections, Intraperitoneal; Kainic Acid; Male; Mice; Neuroglia; Neuroprotective Agents; Proto-Oncogene Proteins c-fos; Seizures; Taurine | 2009 |
Exogenous reelin prevents granule cell dispersion in experimental epilepsy.
Topics: Adaptor Protein Complex 1; Analysis of Variance; Animals; Cell Adhesion Molecules, Neuronal; Cell Count; Cell Movement; Dentate Gyrus; Disease Models, Animal; Drug Delivery Systems; Epilepsy; Excitatory Amino Acid Agonists; Extracellular Matrix Proteins; Gene Expression Regulation; Kainic Acid; LDL-Receptor Related Proteins; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neural Inhibition; Neurons; Neuroprotective Agents; Receptors, LDL; Receptors, Lipoprotein; Reelin Protein; RNA, Messenger; Serine Endopeptidases; Time Factors | 2009 |
Development of spontaneous recurrent seizures after kainate-induced status epilepticus.
Topics: Action Potentials; Animals; Brain; Chronic Disease; Convulsants; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Signal Processing, Computer-Assisted; Status Epilepticus; Telemetry; Time Factors | 2009 |
Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Bicuculline; Biophysics; Bumetanide; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agents; Functional Laterality; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Spectrum Analysis | 2009 |
Seizures in the intrahippocampal kainic acid epilepsy model: characterization using long-term video-EEG monitoring in the rat.
Topics: Animals; Cerebral Cortex; Circadian Rhythm; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Agonists; Female; Hippocampus; Kainic Acid; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time Factors; Video Recording | 2009 |
Hippocampal injury, atrophy, synaptic reorganization, and epileptogenesis after perforant pathway stimulation-induced status epilepticus in the mouse.
Topics: Animals; Antibody Specificity; Atrophy; Cell Count; Dentate Gyrus; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Interneurons; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Perforant Pathway; Receptors, AMPA; Sclerosis; Status Epilepticus; Synapses; Tissue Fixation | 2009 |
Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.
Topics: Amygdala; Animals; Anticonvulsants; Binding Sites; Brain; Disease Models, Animal; Electroshock; Epilepsy; Kainic Acid; Kindling, Neurologic; Levetiracetam; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Pentylenetetrazole; Pharmacogenetics; Phenotype; Piracetam | 2009 |
Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1.
Topics: Action Potentials; Animals; Biological Clocks; Cortical Synchronization; Epilepsy; Excitatory Amino Acid Antagonists; Genetic Predisposition to Disease; Hippocampus; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channels; Kainic Acid; Lamotrigine; Nerve Net; Neurotoxins; Organ Culture Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; RNA, Messenger; Synaptic Transmission; Time Factors; Transcriptional Activation; Triazines | 2009 |
Early-life experience alters response of developing brain to seizures.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Brain; Convulsants; Disease Models, Animal; Encephalitis; Environmental Exposure; Epilepsy; Exploratory Behavior; Female; Gliosis; Hippocampus; Kainic Acid; Male; Maternal Deprivation; Microglia; Nerve Degeneration; Physical Stimulation; Rats; Time | 2009 |
Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis.
Topics: Amygdala; Animals; Convulsants; Down-Regulation; Epilepsy; Fluoresceins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Interneurons; Kainic Acid; Male; Nerve Degeneration; Neural Inhibition; Organic Chemicals; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Kainic Acid; Staining and Labeling; Status Epilepticus; Synaptic Transmission | 2009 |
Decrease in the kainate-induced wet dog shake behavior in genetically epilepsy-prone rats: possible involvement of an impaired synaptic transmission to the 5-HT(2A) receptor.
Topics: Animals; Behavior, Animal; Cytoskeletal Proteins; Disease Models, Animal; Epilepsy; Kainic Acid; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Ritanserin; Synaptic Transmission | 2009 |
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Cause of Death; Death, Sudden; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Kainic Acid; Mice; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Risk Factors; Seizures; Survival Analysis; Tubercidin | 2010 |
Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice.
Topics: Adenosine Kinase; Animals; Astrocytes; Brain; Cell Death; Chronic Disease; Epilepsy; Gliosis; Kainic Acid; Male; Mice; Mice, Knockout; Mice, Transgenic; Pyramidal Cells; Recurrence; Seizures; Severity of Illness Index; Status Epilepticus; Time Factors; Tissue Distribution; Transgenes; Up-Regulation | 2008 |
Transient protective effect of B-vitamins in experimental epilepsy in the mouse brain.
Topics: Animals; bcl-2-Associated X Protein; Behavior, Animal; Brain; Cell Death; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Female; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Vitamin B Complex | 2010 |
The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Drug Interactions; Electroencephalography; Epilepsy; Gene Expression Profiling; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Microtubules; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Oligopeptides; Rats; Rats, Sprague-Dawley | 2009 |
Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta.
Topics: Action Potentials; Animals; Animals, Newborn; Antibodies, Neutralizing; Cells, Cultured; Culture Media, Conditioned; Encephalitis; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Interleukin-1beta; Kainic Acid; Male; Microglia; Nerve Degeneration; Neurons; Neurotoxins; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Up-Regulation | 2010 |
EEG spike activity precedes epilepsy after kainate-induced status epilepticus.
Topics: Action Potentials; Animals; Biomarkers; Brain Injuries; Chronic Disease; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Kainic Acid; Male; Monitoring, Physiologic; Rats; Rats, Sprague-Dawley; Recurrence; Signal Processing, Computer-Assisted; Status Epilepticus; Telemetry; Time Factors; Video Recording | 2010 |
Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.
Topics: Aging; Animals; Aspartic Acid; CA3 Region, Hippocampal; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epilepsy; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; Magnesium Deficiency; Male; Neurons; Neurotransmitter Transport Proteins; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Pyrrolidines; Rats; Rats, Wistar; Synaptic Transmission | 2010 |
Anticonvulsant effects of Searsia dentata (Anacardiaceae) leaf extract in rats.
Topics: Anacardiaceae; Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Epilepsy; Kainic Acid; Male; N-Methylaspartate; Pentylenetetrazole; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Seizures | 2010 |
Urokinase-type plasminogen activator regulates neurodegeneration and neurogenesis but not vascular changes in the mouse hippocampus after status epilepticus.
Topics: Animals; Cell Movement; Cerebral Arteries; Cytoprotection; Disease Models, Animal; Doublecortin Domain Proteins; Doublecortin Protein; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Neovascularization, Pathologic; Nerve Degeneration; Neurogenesis; Neuropeptides; Neurotoxins; Pyramidal Cells; Status Epilepticus; Stem Cells; Urokinase-Type Plasminogen Activator | 2010 |
Network dynamics during development of pharmacologically induced epileptic seizures in rats in vivo.
Topics: Animals; Cortical Synchronization; Electroencephalography; Electrooculography; Epilepsy; Interneurons; Kainic Acid; Male; Nerve Net; Pilocarpine; Rats; Rats, Wistar; Seizures | 2010 |
Timed changes of synaptic zinc, synaptophysin and MAP2 in medial extended amygdala of epileptic animals are suggestive of reactive neuroplasticity.
Topics: Amygdala; Animals; Biomarkers; Convulsants; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Growth Cones; Histocytochemistry; Immunohistochemistry; Kainic Acid; Male; Microtubule-Associated Proteins; Neuronal Plasticity; Presynaptic Terminals; Rats; Rats, Wistar; Septal Nuclei; Staining and Labeling; Synaptophysin; Zinc | 2010 |
Selective reductions in subpopulations of GABAergic neurons in a developmental rat model of epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Image Processing, Computer-Assisted; Immunohistochemistry; Kainic Acid; Male; Neuromuscular Depolarizing Agents; Neurons; Rats; Rats, Sprague-Dawley; Sex Characteristics; Somatostatin | 2010 |
Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus.
Topics: Animals; Anticonvulsants; Astrocytes; Biomarkers; Cell Death; Cytokines; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Hippocampus; Injections, Intraventricular; Interneurons; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Midkine; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Pyramidal Cells | 2010 |
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Hippocampus; HMGB1 Protein; Humans; Interleukin-1beta; Kainic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neurons; Piperidines; Receptors, N-Methyl-D-Aspartate; Seizures; Signal Transduction; Toll-Like Receptor 4 | 2010 |
In vivo expression of neuroglobin in reactive astrocytes during neuropathology in murine models of traumatic brain injury, cerebral malaria, and autoimmune encephalitis.
Topics: Animals; Astrocytes; Autoimmune Diseases of the Nervous System; Brain; Brain Injuries; Disease Models, Animal; Encephalitis; Epilepsy; Female; Globins; Immunohistochemistry; Kainic Acid; Malaria, Cerebral; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroglobin; Neurons | 2010 |
Neonatal exposure to low-dose domoic acid lowers seizure threshold in adult rats.
Topics: Action Potentials; Animals; Animals, Newborn; Convulsants; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Neuromuscular Depolarizing Agents; Pentylenetetrazole; Rats; Rats, Sprague-Dawley | 2010 |
The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat.
Topics: Age Factors; Animals; Brain; Cannabinoid Receptor Antagonists; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy; Kainic Acid; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Recurrence; Rimonabant; Status Epilepticus | 2010 |
Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis.
Topics: Animals; Blotting, Western; Brain; Cyclophilin A; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Epilepsy; Gene Expression; Kainic Acid; Macrophage Migration-Inhibitory Factors; Male; Phytotherapy; Plant Extracts; Proteomics; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Uncaria; Up-Regulation | 2010 |
Over-expression of the DCLK gene transcript CARP decreases CA3/CA1 network excitability.
Topics: Animals; Animals, Genetically Modified; Brain; Calbindin 2; Doublecortin-Like Kinases; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Hippocampus; Kainic Acid; Mice; Muscle Proteins; Neurons; Nuclear Proteins; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Repressor Proteins; RNA, Messenger; S100 Calcium Binding Protein G; Synaptic Transmission; Transcription, Genetic | 2010 |
Domoic acid induced seizures progress to a chronic state of epilepsy in rats.
Topics: Animals; Disease Models, Animal; Disease Progression; Epilepsy; Kainic Acid; Male; Marine Toxins; Neurotoxins; Rats; Rats, Sprague-Dawley; Seizures; Videotape Recording | 2011 |
A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus.
Topics: Age Factors; Animals; Animals, Newborn; Biotinylation; Carbazoles; Enzyme Inhibitors; Epilepsy; Excitatory Amino Acid Agonists; Furosemide; Hippocampus; In Vitro Techniques; Indole Alkaloids; K Cl- Cotransporters; Kainic Acid; Membrane Potentials; Patch-Clamp Techniques; Protein Transport; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Potassium Chloride Symporter Inhibitors; Symporters; Tetrodotoxin | 2010 |
Time-frequency analysis using damped-oscillator pseudo-wavelets: Application to electrophysiological recordings.
Topics: Algorithms; Animals; Data Interpretation, Statistical; Electroencephalography; Electrophysiological Phenomena; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Fourier Analysis; Hippocampus; Kainic Acid; Membrane Potentials; Models, Statistical; Rats; Rats, Sprague-Dawley; Uncertainty; Wavelet Analysis | 2010 |
Decreased glutamine synthetase, increased citrulline-nitric oxide cycle activities, and oxidative stress in different regions of brain in epilepsy rat model.
Topics: Animals; Antioxidants; Arginase; Argininosuccinate Lyase; Argininosuccinate Synthase; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Citrulline; Disease Models, Animal; Epilepsy; Glutamate-Ammonia Ligase; Kainic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances | 2011 |
BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Disease Models, Animal; Dose-Response Relationship, Drug; Doublecortin Protein; Epilepsy; Hippocampus; Kainic Acid; Male; Neurons; Rats; Rats, Inbred F344 | 2011 |
Repetitive perforant-path stimulation induces epileptiform bursts in minislices of dentate gyrus from rats with kainate-induced epilepsy.
Topics: Action Potentials; Animals; Biological Clocks; Dentate Gyrus; Electric Stimulation; Epilepsy; Kainic Acid; Male; Perforant Pathway; Rats; Rats, Sprague-Dawley | 2011 |
Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Dentate Gyrus; Endoplasmic Reticulum; Epilepsy; Excitatory Amino Acid Agonists; Extracellular Matrix; Extracellular Matrix Proteins; Gelatinases; Gene Expression; Golgi Apparatus; Interneurons; Kainic Acid; Nerve Tissue Proteins; Organ Culture Techniques; Peptide Hydrolases; Peptides; Potassium Chloride; Rats; Reelin Protein; Serine Endopeptidases | 2011 |
Activation of GluR6-containing kainate receptors induces ubiquitin-dependent Bcl-2 degradation via denitrosylation in the rat hippocampus after kainate treatment.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Caspase 3; Cell Line, Tumor; Dentate Gyrus; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; GluK2 Kainate Receptor; Hippocampus; Humans; Kainic Acid; Male; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Nitrogen; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Ubiquitin | 2011 |
[Expression of regulation protein of glial fibrillary acidic protein gene in hippocampus of epileptic rats induced by kainic acid].
Topics: Animals; DNA-Binding Proteins; Epilepsy; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley | 2001 |
Diffusion tensor MRI with tract-based spatial statistics and histology reveals undiscovered lesioned areas in kainate model of epilepsy in rat.
Topics: Animals; Anisotropy; Brain; Data Interpretation, Statistical; Diffusion Tensor Imaging; Epilepsy; Histological Techniques; Kainic Acid; Microscopy, Polarization; Rats | 2011 |
Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Baclofen; Clonidine; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Frontal Lobe; Hippocampus; Hypertension; Kainic Acid; Muscimol; N-Methylaspartate; Neurotransmitter Agents; Rats; Rats, Inbred SHR; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate | 2011 |
Capsaicin prevents kainic acid-induced epileptogenesis in mice.
Topics: Animals; Antioxidants; Apoptosis; Body Temperature; Brain; Capsaicin; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Hippocampus; Interleukin-1beta; Kainic Acid; Male; Mice; Mice, Inbred ICR; Tumor Necrosis Factor-alpha | 2011 |
Oral Uncaria rhynchophylla (UR) reduces kainic acid-induced epileptic seizures and neuronal death accompanied by attenuating glial cell proliferation and S100B proteins in rats.
Topics: Administration, Oral; Animals; Blotting, Western; Cell Death; Cell Proliferation; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Nerve Growth Factors; Neuroglia; Plant Extracts; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Uncaria | 2011 |
[Expression of neuropeptides ghrelin and Nesfatin-1 in kainic acid kindling rats].
Topics: Animals; Calcium-Binding Proteins; DNA-Binding Proteins; Epilepsy; Ghrelin; Kainic Acid; Kindling, Neurologic; Male; Nerve Tissue Proteins; Nucleobindins; Rats; Rats, Sprague-Dawley | 2011 |
Induction of Per1 expression following an experimentally induced epilepsy in the mouse hippocampus.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Electroshock; Epilepsy; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Period Circadian Proteins; Potassium Chloride; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Staurosporine | 2011 |
Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice.
Topics: 4-Aminobenzoic Acid; Animals; Anticonvulsants; Convulsants; Dipeptides; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Interleukin-1beta; Kainic Acid; Male; Mice; Mice, Inbred C57BL; para-Aminobenzoates; Seizures | 2011 |
Decrease of calbindin-d28k, calretinin, and parvalbumin by taurine treatment does not induce a major susceptibility to kainic acid.
Topics: Animals; Calbindin 1; Calbindin 2; Calbindins; Calcium-Binding Proteins; Disease Models, Animal; Disease Susceptibility; Down-Regulation; Drug Resistance; Epilepsy; Kainic Acid; Male; Mice; Mice, Inbred Strains; Nerve Degeneration; Neurotoxins; Parvalbumins; S100 Calcium Binding Protein G; Taurine | 2011 |
[DCX and GFAP time-course expression in dentate gyrus of hippocampus following kainic acid-induced seizures on C57/BL6 mice].
Topics: Animals; Dentate Gyrus; Doublecortin Domain Proteins; Doublecortin Protein; Epilepsy; Glial Fibrillary Acidic Protein; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neurons; Neuropeptides | 2011 |
[The effect of high frequency stimulation of epileptic foci on the release of glutamate and gamma-aminobutyric acid in hippocampus of the kainic acid-kindled rats].
Topics: Animals; Electric Stimulation; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley | 2011 |
Effect of neuronal excitotoxicity on Munc18-1 distribution in nuclei of rat hippocampal neuron and primary cultured neuron.
Topics: Animals; Cell Nucleus; Cells, Cultured; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred Strains; Munc18 Proteins; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley | 2011 |
Neuroprotective role of PrPC against kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6/7-PSD-95 binding.
Topics: Animals; Cell Death; Disks Large Homolog 4 Protein; Down-Regulation; Enzyme Activation; Epilepsy; Extracellular Signal-Regulated MAP Kinases; Gene Expression; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Guanylate Kinases; Hippocampus; Kainic Acid; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 10; Neurons; Primary Cell Culture; Prion Proteins; Prions; Protein Binding; PrPC Proteins; Receptors, Kainic Acid | 2011 |
Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures.
Topics: Acetoacetates; Animals; Body Weight; CD11b Antigen; Cell Line; Cell Survival; Cyclooxygenase 2; Diet, Ketogenic; Encephalitis; Epilepsy; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; PPAR gamma; Tumor Necrosis Factor-alpha | 2011 |
Targeting pannexin1 improves seizure outcome.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Behavior, Animal; Blotting, Western; Brain; Cells, Cultured; Connexins; Epilepsy; Fluorescent Antibody Technique; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Potassium; Seizures; Status Epilepticus | 2011 |
A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Food, Formulated; Kainic Acid; Male; Pharmaceutical Preparations; Rats; Seizures; Status Epilepticus; Time Factors; Treatment Outcome | 2012 |
Habenula regulates cardiovascular activities in the insula cortex in a rat model of epilepsy.
Topics: Animals; Behavior, Animal; Blood Pressure; Cerebral Cortex; Disease Models, Animal; Epilepsy; Habenula; Heart Rate; Kainic Acid; Norepinephrine; Rats; Rats, Wistar | 2012 |
Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Matrix Metalloproteinase 7; Nerve Degeneration; Nerve Growth Factors; Neuroprotective Agents; Organ Culture Techniques; Protein Precursors; Rats; Rats, Sprague-Dawley | 2012 |
Neuroprotection by urokinase plasminogen activator in the hippocampus.
Topics: Acute Disease; Animals; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Neurons; Neuroprotective Agents; Urokinase-Type Plasminogen Activator | 2012 |
Somatostatin and neuropeptide Y neurons undergo different plasticity in parahippocampal regions in kainic acid-induced epilepsy.
Topics: Animals; Entorhinal Cortex; Epilepsy; Hippocampus; Interneurons; Kainic Acid; Male; Neuronal Plasticity; Neuropeptide Y; Parahippocampal Gyrus; Rats; Rats, Sprague-Dawley; Somatostatin | 2012 |
Distinct hyperexcitability mechanisms underlie fast ripples and epileptic spikes.
Topics: Action Potentials; Animals; Epilepsy; Hippocampus; Kainic Acid; Mice; Neural Networks, Computer; Neurons; Organ Culture Techniques; Rats; Rats, Wistar; Time Factors | 2012 |
Abnormalities of granule cell dendritic structure are a prominent feature of the intrahippocampal kainic acid model of epilepsy despite reduced postinjury neurogenesis.
Topics: Animals; Bacterial Proteins; Calbindin 2; Carrier Proteins; Cation Transport Proteins; Cell Count; Dendrites; Disease Models, Animal; Epilepsy; Functional Laterality; Hippocampus; Kainic Acid; Ki-67 Antigen; Luminescent Proteins; Male; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Mossy Fibers, Hippocampal; Neurons; Phosphopyruvate Hydratase; S100 Calcium Binding Protein G | 2012 |
The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway.
Topics: Animals; Behavior, Animal; Blotting, Western; Epilepsy; Immunohistochemistry; Kainic Acid; Locomotion; Male; Rats; Seizures; TOR Serine-Threonine Kinases | 2012 |
Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death.
Topics: Animals; Blotting, Western; Cell Death; Convulsants; Electroencephalography; Epilepsy; Gene Expression Profiling; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Neurons; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Seizures; Up-Regulation | 2012 |
Ketogenic diet reduces Smac/Diablo and cytochrome c release and attenuates neuronal death in a mouse model of limbic epilepsy.
Topics: 3-Hydroxybutyric Acid; Analysis of Variance; Animals; Apoptosis Regulatory Proteins; Carrier Proteins; Caspase 3; Caspase 9; Cell Death; Cytochromes c; Diet, Ketogenic; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; In Situ Nick-End Labeling; Kainic Acid; Limbic System; Male; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Neurons | 2012 |
Stimulation of the anterior nucleus of the thalamus induces changes in amino acids in the hippocampi of epileptic rats.
Topics: Amino Acids; Analysis of Variance; Animals; Anterior Thalamic Nuclei; Biophysics; Disease Models, Animal; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agonists; Functional Laterality; Hippocampus; Kainic Acid; Male; Microdialysis; Neural Pathways; Rats; Rats, Wistar; Time Factors | 2012 |
The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cholinergic Agents; Convulsants; Electroencephalography; Electrophysiological Phenomena; Epilepsy; Genes, fos; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Mice; Mice, Knockout; Nerve Tissue Proteins; Organic Anion Transporters, Sodium-Dependent; Pilocarpine; Proto-Oncogene Proteins c-fos; Real-Time Polymerase Chain Reaction; Symporters; Synapses; Vesicular Transport Proteins | 2013 |
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.
Topics: Animals; Anticonvulsants; Association Learning; Brain; Carbamazepine; Cognition Disorders; Epilepsy; Ethosuximide; Hyperkinesis; Kainic Acid; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Nimodipine; Seizures; Synaptosomal-Associated Protein 25; Valproic Acid | 2014 |
Altered GABAA receptor density and unaltered blood-brain barrier transport in a kainate model of epilepsy: an in vivo study using 11C-flumazenil and PET.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Carbon Radioisotopes; Epilepsy; Flumazenil; Kainic Acid; Male; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2012 |
fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior.
Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Depression; Disease Models, Animal; Doublecortin Domain Proteins; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microarray Analysis; Microtubule-Associated Proteins; Mutation; Neurogenesis; Neuropeptides; Phosphopyruvate Hydratase; Proto-Oncogene Proteins c-fos | 2013 |
Involvement of the neuropeptide orphanin FQ/nociceptin in kainate and kindling seizures and epileptogenesis.
Topics: Animals; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knockout; Nociceptin; Nociceptin Receptor; Opioid Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Seizures | 2002 |
Interaction of excitatory amino acid agonists with cortical afterdischarges in developing rats.
Topics: Aging; Animals; Cerebral Cortex; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Homocysteine; Kainic Acid; N-Methylaspartate; Rats; Rats, Wistar | 2002 |
Rate of interictal events and spontaneous seizures in epileptic rats after electrical stimulation of hippocampus and its afferents.
Topics: Afferent Pathways; Animals; Convulsants; Electric Stimulation; Epilepsy; Evoked Potentials; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Long-Term Potentiation; Male; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors | 2002 |
Epileptiform spikes desynchronize and diminish fast (gamma) activity of the brain. An "anti-binding" mechanism?
Topics: Animals; Brain; Cortical Synchronization; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Male; Periodicity; Rats; Rats, Sprague-Dawley | 2002 |
Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Death; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Laser-Doppler Flowmetry; Limbic System; Male; Mice; Mice, Inbred C57BL; Neurons | 2002 |
Morphologic study of neuronal death, glial activation, and progenitor cell division in the hippocampus of rat models of epilepsy.
Topics: Animals; Bromodeoxyuridine; Cell Death; Cell Division; Disease Models, Animal; DNA Fragmentation; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; In Vitro Techniques; Injections, Intraperitoneal; Kainic Acid; Kindling, Neurologic; Male; Microglia; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Stem Cells; Time Factors | 2002 |
Effect of carbamazepine on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Electroencephalography; Electromyography; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Male; Rats; Sleep; Sleep Stages; Sleep, REM | 2002 |
Epilepsy-induced changes in signaling systems of human and rat postsynaptic densities.
Topics: Adolescent; Adult; Animals; Cerebral Cortex; Child; Child, Preschool; Down-Regulation; Epilepsy; Female; Humans; Infant; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; Up-Regulation | 2003 |
Ganglioside GT1B and melatonin inhibit brain mitochondrial DNA damage and seizures induced by kainic acid in mice.
Topics: Animals; Brain; Cell Death; DNA Damage; DNA, Mitochondrial; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Free Radicals; Gangliosides; Kainic Acid; Male; Melatonin; Mice; Mitochondria; Neurons; Oxidative Stress | 2003 |
Kainic acid modifies mu-receptor binding in young, adult, and elderly rat brain.
Topics: Aging; Animals; Animals, Newborn; Binding Sites; Brain; Convulsants; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Epilepsy; Kainic Acid; Male; Neurons; Opioid Peptides; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, mu; Status Epilepticus; Up-Regulation | 2002 |
Ultrastructural features of sprouted mossy fiber synapses in kindled and kainic acid-treated rats.
Topics: Animals; Epilepsy; Growth Cones; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Male; Microscopy, Electron; Mossy Fibers, Hippocampal; Neuronal Plasticity; Rats; Rats, Sprague-Dawley | 2003 |
Reduced expression of calsenilin/DREAM/KChIP3 in the brains of kainic acid-induced seizure and epilepsy patients.
Topics: Animals; Brain; Calcium-Binding Proteins; Down-Regulation; Epilepsy; Gene Expression Regulation; Humans; Kainic Acid; Kv Channel-Interacting Proteins; Male; Mice; Mice, Inbred C57BL; Patients; Repressor Proteins; Seizures | 2003 |
Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell loss.
Topics: Animals; Cell Count; Cell Death; Disease Models, Animal; Epilepsy; Genetic Vectors; Heat-Shock Proteins; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; Simplexvirus; Stress, Physiological; Treatment Outcome | 2003 |
Differences in ionotropic glutamate receptor subunit expression are not responsible for strain-dependent susceptibility to excitotoxin-induced injury.
Topics: Animals; Cell Death; Disease Models, Animal; Drug Resistance; Epilepsy; Genetic Predisposition to Disease; Glutamic Acid; Immunohistochemistry; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurotoxins; Protein Subunits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Species Specificity; Synaptic Transmission | 2003 |
BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development.
Topics: Age Factors; Animals; Animals, Newborn; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Central Nervous System; Central Nervous System Diseases; Central Nervous System Viral Diseases; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; Genetic Vectors; Hippocampus; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Knockout; Neurodegenerative Diseases; Neurons; Neurotoxins; Protein Structure, Tertiary; Sindbis Virus; Stroke; Synaptic Transmission | 2003 |
Down-regulation of GABA-transporter function by hippocampal translation products: its possible role in epilepsy.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Down-Regulation; Epilepsy; Excitatory Amino Acid Agonists; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Mice; Oocytes; Organic Anion Transporters; Patch-Clamp Techniques; RNA, Complementary; RNA, Messenger; Tritium; Xenopus laevis | 2003 |
Altered expression of GABAB receptors in the hippocampus after kainic-acid-induced seizures in rats.
Topics: Animals; Dentate Gyrus; Down-Regulation; Epilepsy; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Neural Inhibition; Neural Pathways; Neurons; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; RNA, Messenger; Synaptic Transmission; Up-Regulation | 2003 |
In vivo modulation of hippocampal epileptiform activity with radial electric fields.
Topics: Amplifiers, Electronic; Animals; Disease Models, Animal; Electric Stimulation; Electric Stimulation Therapy; Electrodes, Implanted; Electronics, Medical; Epilepsy; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Male; Membrane Potentials; Microelectrodes; Rats; Rats, Sprague-Dawley; Seizures; Stereotaxic Techniques | 2003 |
Increased vulnerability to kainic acid-induced epileptic seizures in mice underexpressing the scaffold protein Islet-Brain 1/JIP-1.
Topics: Adaptor Proteins, Signal Transducing; Animals; Blotting, Western; Carrier Proteins; Cell Death; Cell Nucleus; Cytoplasm; Epilepsy; Excitatory Amino Acid Agonists; Female; Gene Expression; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Kainic Acid; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Microscopy, Electron; Time Factors | 2003 |
Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo.
Topics: Action Potentials; Animals; Diffusion Chambers, Culture; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Kainic Acid; Male; Neural Inhibition; Patch-Clamp Techniques; Pentobarbital; Perfusion; Periodicity; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2003 |
Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy.
Topics: Amino Acid Transport System X-AG; Animals; Cell Line; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Kainic Acid; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Symporters | 2003 |
Protection provided by cyclosporin A against excitotoxic neuronal death is genotype dependent.
Topics: Animals; Cell Death; Cyclosporine; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Genotype; Hippocampus; Ion Channels; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Neurons; Neuroprotective Agents; Phenotype; Premedication; Tacrolimus | 2003 |
GluR2(B) knockdown accelerates CA3 injury after kainate seizures.
Topics: Animals; Calcium Signaling; Cell Death; Epilepsy; Glutamic Acid; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Nerve Degeneration; Neurons; Neurotoxins; Oligonucleotides, Antisense; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Status Epilepticus | 2003 |
Prevention of epileptic seizures by taurine.
Topics: Animals; Chloride Channel Agonists; Chloride Channels; Epilepsy; Kainic Acid; Male; Receptors, GABA-A; Taurine | 2003 |
Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain.
Topics: Animals; Brain; Calcium-Binding Proteins; Densitometry; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Immunoblotting; Kainic Acid; Male; Nerve Tissue Proteins; Neurons; Protein Isoforms; Rats; Rats, Wistar; Synapses; Synaptic Membranes | 2003 |
Continuous administration of antisense oligonucleotides to c-fos reduced the development of seizure susceptibility after ethacrynic acid-induced seizure in mice.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Epilepsy; Ethacrynic Acid; Gene Expression Regulation; Genetic Predisposition to Disease; Injections, Intraventricular; Kainic Acid; Male; Mice; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-fos; Up-Regulation | 2003 |
In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures.
Topics: Animals; Animals, Newborn; Chloride Channels; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Functional Laterality; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Male; Membrane Potentials; Neural Pathways; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2003 |
Neuroscience. Stout guards of the central nervous system.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Brain; Brain Diseases; Cannabidiol; Cannabinoid Receptor Modulators; Cannabinoids; Convulsants; Dronabinol; Endocannabinoids; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycerides; Humans; Kainic Acid; Mice; Neurons; Neuroprotective Agents; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction | 2003 |
CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
Topics: Animals; Arachidonic Acids; Brain; Brain-Derived Neurotrophic Factor; Cannabinoids; Endocannabinoids; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Furans; gamma-Aminobutyric Acid; Gene Expression Regulation; Genes, Immediate-Early; Glutamic Acid; Glycerides; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mitogen-Activated Protein Kinases; Mutation; Neurons; Neuroprotective Agents; Piperidines; Polyunsaturated Alkamides; Prosencephalon; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Signal Transduction | 2003 |
Upregulation of gp130 and differential activation of STAT and p42/44 MAPK in the rat hippocampus following kainic acid-induced seizures.
Topics: Animals; Antigens, CD; Cytokine Receptor gp130; Disease Models, Animal; DNA-Binding Proteins; Epilepsy; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Membrane Glycoproteins; Mitogen-Activated Protein Kinase 1; Rats; Rats, Sprague-Dawley; RNA, Messenger; STAT1 Transcription Factor; STAT3 Transcription Factor; Status Epilepticus; Trans-Activators; Up-Regulation | 2003 |
Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures.
Topics: Animals; Carrier Proteins; Cell Membrane; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoenzymes; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Mossy Fibers, Hippocampal; Neurons; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2003 |
Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development.
Topics: Aging; Animals; Animals, Newborn; Cytokines; Disease Models, Animal; Disease Susceptibility; Epilepsy; Female; Gliosis; Hippocampus; Inflammation Mediators; Interleukin 1 Receptor Antagonist Protein; Kainic Acid; Male; Nerve Degeneration; Neuroglia; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sialoglycoproteins; Status Epilepticus; Up-Regulation | 2003 |
Herpes simplex virus type 1 inoculation enhances hippocampal excitability and seizure susceptibility in mice.
Topics: Action Potentials; Animals; Causality; Cell Membrane; Disease Models, Animal; Disease Susceptibility; Electric Impedance; Encephalitis, Herpes Simplex; Epilepsy; Epilepsy, Temporal Lobe; Herpesvirus 1, Human; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Neural Pathways; Organ Culture Techniques; Pyramidal Cells; Viral Proteins | 2003 |
Interactive effects of excitotoxic injury and dietary restriction on microgliosis and neurogenesis in the hippocampus of adult mice.
Topics: Animals; Bromodeoxyuridine; Cell Division; Down-Regulation; Epilepsy; Food Deprivation; Gliosis; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Nerve Regeneration; Neurons; Neurotoxins; Stem Cells | 2003 |
Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters.
Topics: Animals; Biopsy; Brain; Disease Models, Animal; Electrophysiology; Epilepsy; Functional Laterality; Hippocampus; Kainic Acid; Male; Microelectrodes; Neurons; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA | 2004 |
Expression of B/K protein in the hippocampus of kainate-induced rat seizure model.
Topics: Animals; Carrier Proteins; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors; Epilepsy; Excitatory Amino Acid Agonists; Heat-Shock Proteins; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Microscopy, Electron; Molecular Chaperones; Nerve Tissue Proteins; Neurons; PC12 Cells; Rats; Rats, Sprague-Dawley; Reaction Time; Stress, Physiological; Synaptotagmins; Up-Regulation | 2004 |
Mitochondrial oxidative stress and increased seizure susceptibility in Sod2(-/+) mice.
Topics: Aconitate Hydratase; Amino Acid Transport System X-AG; Animals; Deoxyadenosines; Epilepsy; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Mice; Mice, Knockout; Mitochondria; Neurodegenerative Diseases; Neurotoxins; Oxidative Stress; Oxygen; Seizures; Superoxide Dismutase; Superoxides | 2004 |
Effects of chronic administration of PL017 and beta-funaltrexamine hydrochloride on susceptibility of kainic acid-induced seizures in rats.
Topics: Animals; Disease Susceptibility; Dynorphins; Epilepsy; Hippocampus; Kainic Acid; Male; Naltrexone; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2004 |
Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus.
Topics: Animals; Dependovirus; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Hippocampus; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Male; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Seizures; Treatment Outcome | 2004 |
Increased excitatory synaptic activity and local connectivity of hippocampal CA1 pyramidal cells in rats with kainate-induced epilepsy.
Topics: Animals; Epilepsy; Excitatory Postsynaptic Potentials; Hippocampus; Kainic Acid; Male; Nerve Net; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 2004 |
Ontogeny of seizure-induced increases in BDNF immunoreactivity and TrkB receptor activation in rat hippocampus.
Topics: Aging; Animals; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Disease Models, Animal; Epilepsy; Hippocampus; Immunohistochemistry; Kainic Acid; Mossy Fibers, Hippocampal; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, trkB; Status Epilepticus; Up-Regulation | 2004 |
Clinical and experimental studies of epilepsy associated with focal cortical dysplasia.
Topics: Animals; Animals, Newborn; Blood Vessels; Brain; Brain Neoplasms; Cerebrovascular Circulation; Disease Models, Animal; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Male; Motor Cortex; Neoplasms, Neuroepithelial; Rats; Rats, Wistar; Somatosensory Cortex | 2004 |
Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Non-Narcotic; Animals; Binding, Competitive; Electroshock; Epilepsy; Excitatory Amino Acid Agonists; Glutamic Acid; Ion Channel Gating; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Nefopam; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Sodium Channels; Synaptic Transmission; Tritium | 2004 |
Hippocampal neurotransplantation evaluated in the rat kainic acid epilepsy model.
Topics: Animals; Cytotoxins; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Male; Maze Learning; Neurons; Rats; Rats, Sprague-Dawley | 2004 |
Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis.
Topics: Animals; Biological Transport; Brain-Derived Neurotrophic Factor; Cell Compartmentation; Convulsants; Dendrites; Dizocilpine Maleate; Electroshock; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Pilocarpine; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Status Epilepticus; Synapses | 2004 |
Measurement of cortical and hippocampal epileptiform activity in freely moving rats by means of implantable radiotelemetry.
Topics: Animals; Body Temperature; Cerebral Cortex; Electrodes, Implanted; Electroencephalography; Electromyography; Epilepsy; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Rats; Rats, Wistar; Telemetry; Time Factors; Wakefulness | 2004 |
High-frequency oscillations after status epilepticus: epileptogenesis and seizure genesis.
Topics: Animals; Cortical Synchronization; Dentate Gyrus; Electrodes, Implanted; Electroencephalography; Epilepsy; Evoked Potentials; Functional Laterality; Hippocampus; Interneurons; Kainic Acid; Microelectrodes; Rats; Rats, Wistar; Reaction Time; Recurrence; Seizures; Status Epilepticus; Time Factors | 2004 |
[Neuronal damage in the hippocampus of inbred mouse strains in the models of epilepsy induced by kainic acid and pilocarpine].
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred Strains; Neurons; Pilocarpine; Species Specificity | 2004 |
[Changes of amino acid content in hippocampus of epileptic rats treated with volatile oil of Acorus tatarinowii].
Topics: Acorus; Animals; Anticonvulsants; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Male; Oils, Volatile; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 2004 |
Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity.
Topics: Animals; Brain; Carrier Proteins; Cells, Cultured; Chlorocebus aethiops; COS Cells; Epilepsy; Freund's Adjuvant; Hippocampus; Humans; Immunohistochemistry; In Vitro Techniques; Inflammation; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Synapses; Transfection; Ubiquitin-Protein Ligases | 2004 |
Epilepsy induced by extended amygdala-kindling in rats: lack of clear association between development of spontaneous seizures and neuronal damage.
Topics: Amygdala; Analysis of Variance; Animals; Cell Count; Differential Threshold; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy; Female; Hippocampus; Kainic Acid; Kindling, Neurologic; Nervous System Diseases; Neurons; Pilocarpine; Rats; Rats, Wistar; Seizures; Time Factors; Video Recording | 2004 |
Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid-induced epileptic seizures.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Astrocytes; Cell Count; Cell Death; Central Nervous System Diseases; Epilepsy; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Growth Substances; Guanine; Hippocampus; Immunohistochemistry; In Situ Nick-End Labeling; Interleukins; Kainic Acid; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurodegenerative Diseases; Neurofibrillary Tangles; Staining and Labeling; Tyrosine | 2005 |
Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Epilepsy; Fructose; Injections, Intraperitoneal; Kainic Acid; Pilocarpine; Rats; Rats, Sprague-Dawley; Research Design; Sodium Chloride; Status Epilepticus; Topiramate | 2005 |
Role of nitric oxide in cerebral blood flow changes during kainate seizures in mice: genetic and pharmacological approaches.
Topics: Animals; Antipyrine; Brain; Cerebral Cortex; Cerebrovascular Circulation; Convulsants; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Functional Laterality; Hippocampus; Indazoles; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Status Epilepticus | 2005 |
Up-regulation of peripherin is associated with alterations in synaptic plasticity in CA1 and CA3 regions of hippocampus.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Disease Models, Animal; Down-Regulation; Epilepsy; Fluorescent Antibody Technique; Gene Expression; Genetic Predisposition to Disease; Hippocampus; Intermediate Filament Proteins; Kainic Acid; Long-Term Potentiation; Membrane Glycoproteins; Mice; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neuronal Plasticity; Organ Culture Techniques; Peripherins; Promoter Regions, Genetic; Synaptic Transmission; Synaptophysin; Thalamus; Up-Regulation | 2005 |
Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death.
Topics: Animals; Cell Death; Cells, Cultured; Disease Models, Animal; Epilepsy; Genetic Predisposition to Disease; Glutathione Disulfide; Glutathione Peroxidase; Hippocampus; Kainic Acid; Mice; Mice, Transgenic; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Organ Culture Techniques; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Up-Regulation | 2005 |
Characterization of cell proliferation in the adult dentate under normal conditions and after kainate induced seizures using ribonucleotide reductase and BrdU.
Topics: Animals; Astrocytes; Biomarkers; Bromodeoxyuridine; Caspase 3; Caspases; Cell Death; Cell Proliferation; Convulsants; Dentate Gyrus; Epilepsy; Fluorescent Antibody Technique; Kainic Acid; Male; Nerve Degeneration; Nerve Regeneration; Neuronal Plasticity; Neurons; Rats; Rats, Sprague-Dawley; Recovery of Function; Ribonucleotide Reductases; Stem Cells; Up-Regulation | 2005 |
Proteolysis of NR2B by calpain in the hippocampus of epileptic rats.
Topics: Animals; Calpain; Enzyme Activation; Epilepsy; Hippocampus; Kainic Acid; Male; Peptide Hydrolases; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2005 |
Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy.
Topics: Animals; Blotting, Western; Caspase 6; Caspases; Electrodes, Implanted; Electroencephalography; Enzyme Activation; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Kinetics; Male; Neurons; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2005 |
Up-regulation of neuropeptide Y levels and modulation of glutamate release through neuropeptide Y receptors in the hippocampus of kainate-induced epileptic rats.
Topics: Animals; Disease Models, Animal; Drug Interactions; Epilepsy; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neuropeptide Y; Peptide Fragments; Potassium Chloride; Rats; Rats, Wistar; Receptors, Neuropeptide Y; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Up-Regulation | 2005 |
Patterns of dentate granule cell responses to perforant path stimulation in epileptic mice with granule cell dispersion.
Topics: Action Potentials; Animals; Behavior, Animal; Carbazoles; Cell Count; Disease Models, Animal; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Epilepsy; Hippocampus; Immunohistochemistry; Indole Alkaloids; Kainic Acid; Mice; Neurons; Neuropeptide Y; Perforant Pathway; Staining and Labeling; Time Factors | 2005 |
Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors.
Topics: Animals; Anticonvulsants; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Tumor Necrosis Factor-alpha | 2005 |
Histamine H(1) and H(3) receptors in the rat thalamus and their modulation after systemic kainic acid administration.
Topics: Animals; Binding, Competitive; Down-Regulation; Epilepsy; Excitatory Amino Acid Agonists; Histamine; Kainic Acid; Male; Protein Isoforms; Protein Structure, Tertiary; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Histamine H1; Receptors, Histamine H3; RNA, Messenger; Status Epilepticus; Thalamus; Up-Regulation | 2005 |
Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus.
Topics: Action Potentials; Animals; Brain Chemistry; Calbindins; Chronic Disease; Disease Models, Animal; Down-Regulation; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Functional Laterality; Galanin; Hippocampus; Kainic Acid; Mice; Mossy Fibers, Hippocampal; Nerve Degeneration; Neural Pathways; Neuropeptide Y; Neurotoxins; Pyramidal Cells; S100 Calcium Binding Protein G; Sincalide; Status Epilepticus; Theta Rhythm; Up-Regulation | 2005 |
ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus.
Topics: ADAM Proteins; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Convulsants; Dentate Gyrus; Disease Models, Animal; Disintegrins; Endopeptidases; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Male; Membrane Proteins; Metalloendopeptidases; Metalloproteases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Status Epilepticus; Up-Regulation | 2005 |
Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors.
Topics: Animals; Cells, Cultured; Convulsants; Cyclohexanes; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neurons; Neuropeptide Y; Organ Culture Techniques; Receptors, Neuropeptide Y; Synaptic Transmission; Xanthenes | 2005 |
Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus.
Topics: Animals; Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Hippocampus; Kainic Acid; Male; Neurons; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley | 2005 |
Physiological changes in chronic epileptic rats are prominent in superficial layers of the medial entorhinal area.
Topics: Animals; Cell Count; Cell Death; Chronic Disease; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy; Evoked Potentials; Hippocampus; Kainic Acid; Male; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley | 2005 |
Detection of increased local excitatory circuits in the hippocampus during epileptogenesis using focal flash photolysis of caged glutamate.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Kainic Acid; Male; Models, Neurological; Mossy Fibers, Hippocampal; Neural Pathways; Patch-Clamp Techniques; Photolysis; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Status Epilepticus; Synaptic Transmission | 2005 |
Proechimys guyannensis: an animal model of resistance to epilepsy.
Topics: Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; Immunity, Innate; Kainic Acid; Kindling, Neurologic; Male; Pilocarpine; Rats; Rats, Wistar; Rodentia; Species Specificity; Status Epilepticus | 2005 |
Susceptibility to seizure-induced injury and acquired microencephaly following intraventricular injection of saporin-conjugated 192 IgG in developing rat brain.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Atrophy; Basal Nucleus of Meynert; Brain Damage, Chronic; Cholinergic Agents; Convulsants; Disease Models, Animal; Disease Susceptibility; Epilepsy; Excitatory Amino Acid Agonists; Female; Immunotoxins; Injections, Intraventricular; Kainic Acid; Male; N-Glycosyl Hydrolases; Nerve Degeneration; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Ribosome Inactivating Proteins, Type 1; Saporins | 2005 |
Effect of kainate-induced experimental epilepsy on NADPH-diaphorase and calcium-binding proteins in rat hippocampal neurons.
Topics: Animals; Calbindin 2; Calbindins; Epilepsy; Hippocampus; Immunohistochemistry; Interneurons; Kainic Acid; NADPH Dehydrogenase; Pyramidal Cells; Rats; Rats, Inbred Strains; S100 Calcium Binding Protein G | 2005 |
Suppression of secondary generalization of limbic seizures by stimulation of subthalamic nucleus in rats.
Topics: Animals; Deep Brain Stimulation; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Functional Laterality; Kainic Acid; Limbic System; Male; Rats; Rats, Sprague-Dawley; Subthalamic Nucleus | 2005 |
Mini-I on epilepsy. Focus on "Changes in mIPSCs and sIPSCs after kainate treatment: evidence for loss of inhibitory input to dentate granule cells and possible compensatory responses".
Topics: Animals; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Neural Inhibition; Neurons; Patch-Clamp Techniques; Synaptic Transmission | 2005 |
Stereological analysis of forebrain regions in kainate-treated epileptic rats.
Topics: Analysis of Variance; Animals; Brain Mapping; Cell Count; Epilepsy; Glutamate Decarboxylase; Imaging, Three-Dimensional; In Situ Hybridization; Isoenzymes; Kainic Acid; Male; Neurons; Prosencephalon; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques | 2005 |
Transient changes in the limbic histaminergic system after systemic kainic acid-induced seizures.
Topics: Amygdala; Animals; Axons; Epilepsy; Hippocampus; Histamine; Kainic Acid; Limbic System; Male; MAP Kinase Signaling System; Neural Pathways; Olfactory Pathways; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; RNA, Messenger; Status Epilepticus; Up-Regulation | 2005 |
Increase in hippocampal cell death after treatment with kainate in zinc deficiency.
Topics: Animals; Cell Death; Disease Models, Animal; Disease Susceptibility; Epilepsy; Excitatory Amino Acid Agonists; Extracellular Fluid; Food, Formulated; Hippocampus; In Situ Nick-End Labeling; Injections, Intraperitoneal; Kainic Acid; Male; Mice; Nerve Degeneration; Neurotoxins; Pyramidal Cells; Up-Regulation; Zinc | 2005 |
Presubiculum stimulation in vivo evokes distinct oscillations in superficial and deep entorhinal cortex layers in chronic epileptic rats.
Topics: Animals; Biological Clocks; Entorhinal Cortex; Epilepsy; Kainic Acid; Male; Nerve Net; Rats; Rats, Sprague-Dawley | 2005 |
Dopaminergic drugs may counteract behavioral and biochemical changes induced by models of brain injury.
Topics: Amnesia; Animals; Antioxidants; Behavior, Animal; Brain Diseases; Brain Ischemia; Dopamine Agents; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Glutathione; Hypoxia, Brain; Injections, Intraventricular; Injections, Subcutaneous; Kainic Acid; Male; Motor Activity; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 2006 |
Ketogenic diet decreases the level of proenkephalin mRNA induced by kainic acid in the mouse hippocampus.
Topics: Animals; Diet, Carbohydrate-Restricted; Diet, Protein-Restricted; Dietary Fats; Enkephalins; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Protein Precursors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Transcription Factor AP-1; Treatment Outcome | 2006 |
Studies of damage to hippocampal neurons in inbred mouse lines in models of epilepsy using kainic acid and pilocarpine.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Epilepsy; Hippocampus; HSP70 Heat-Shock Proteins; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neurons; Pilocarpine; Species Specificity | 2005 |
CA3 axonal sprouting in kainate-induced chronic epilepsy.
Topics: Animals; Axons; Cell Count; Chronic Disease; Coloring Agents; Dentate Gyrus; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Horseradish Peroxidase; Immunohistochemistry; Kainic Acid; Male; Mossy Fibers, Hippocampal; Phytohemagglutinins; Rats; Rats, Sprague-Dawley; Seizures | 2005 |
Febrile convulsions induced by the combination of lipopolysaccharide and low-dose kainic acid enhance seizure susceptibility, not epileptogenesis, in rats.
Topics: Age Factors; Amygdala; Animals; Animals, Newborn; Body Temperature; Disease Models, Animal; Disease Susceptibility; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Epilepsy; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Lipopolysaccharides; Male; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Seizures; Seizures, Febrile | 2005 |
Chronic bilateral stimulation of the anterior thalamus of kainate-treated rats increases seizure frequency.
Topics: Acute Disease; Animals; Anterior Thalamic Nuclei; Deep Brain Stimulation; Disease Models, Animal; Electric Stimulation Therapy; Electroencephalography; Epilepsy; Functional Laterality; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Status Epilepticus; Videotape Recording | 2006 |
Environmental enrichment reverses the impaired exploratory behavior and altered gene expression induced by early-life seizures.
Topics: Animals; Disease Models, Animal; Environment; Epilepsy; Excitatory Amino Acid Agonists; Exploratory Behavior; Gene Expression Regulation, Developmental; Kainic Acid; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Long-Evans; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2005 |
The use of radiotelemetry to evaluate electrographic seizures in rats with kainate-induced epilepsy.
Topics: Action Potentials; Animals; Behavior, Animal; Brain; Cerebral Cortex; Convulsants; Cost-Benefit Analysis; Disease Models, Animal; Electroencephalography; Electronics, Medical; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Microelectrodes; Neurons; Neurophysiology; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Status Epilepticus; Telemetry; Time Factors | 2006 |
Electro-acupuncture improves epileptic seizures induced by kainic acid in taurine-depletion rats.
Topics: Animals; Brain; Electroacupuncture; Epilepsy; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Taurine; Treatment Outcome | 2005 |
Alterations of taurine in the brain of chronic kainic acid epilepsy model.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Rats; Rats, Sprague-Dawley; Seizures; Taurine | 2006 |
[Effect of ketogenic diet on hippocampus synaptic reorganization and GluR5 expression in kainic acid induced rat model of epilepsy].
Topics: Animals; Blotting, Western; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Chromosome Pairing; Dentate Gyrus; Diet, Ketogenic; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mossy Fibers, Hippocampal; Pyramidal Cells; Rats; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
A mechanism for the inactivation of Ca2+/calmodulin-dependent protein kinase II during prolonged seizure activity and its consequence after the recovery from seizure activity in rats in vivo.
Topics: Animals; Brain; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Convulsants; Disease Models, Animal; Enzyme Activation; Epilepsy; Kainic Acid; Male; Membrane Potentials; Neurons; Phosphorylation; Rats; Rats, Wistar; Recovery of Function; Solubility; Status Epilepticus; Threonine | 2006 |
P2X7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brain.
Topics: Animals; Astrocytes; Biomarkers; Brain; Calcium-Binding Proteins; Convulsants; Cyclooxygenase 1; Disease Models, Animal; Encephalitis; Epilepsy; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Kainic Acid; Male; Membrane Proteins; Microfilament Proteins; Microglia; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X7 | 2006 |
Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures.
Topics: Animals; Biomarkers; Convulsants; Cyclooxygenase 2; Disease Models, Animal; Encephalitis; Epilepsy; Gliosis; Glutamic Acid; Immunohistochemistry; Kainic Acid; Limbic System; Male; Microglia; Olfactory Pathways; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Up-Regulation | 2006 |
Fear conditioning is impaired in systemic kainic acid and amygdala-stimulation models of epilepsy.
Topics: Acoustic Stimulation; Amygdala; Animals; Behavior, Animal; Conditioning, Classical; Cues; Disease Models, Animal; Electric Stimulation; Epilepsy; Epilepsy, Temporal Lobe; Fear; Freezing Reaction, Cataleptic; Kainic Acid; Male; Motor Activity; Rats; Rats, Wistar; Status Epilepticus; Videotape Recording | 2006 |
Adenosine A1 receptors are crucial in keeping an epileptic focus localized.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy; Female; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Adenosine A1; Status Epilepticus | 2006 |
Focal cortical dysplasia: pathophysiological approach.
Topics: Adolescent; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Brain Diseases; Brain Mapping; Cerebral Cortex; Child; Electroencephalography; Epilepsy; Female; Flumazenil; gamma-Aminobutyric Acid; Humans; Immunohistochemistry; Iodine Radioisotopes; Kainic Acid; Male; Nervous System Malformations; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2006 |
Regulation and role of REST and REST4 variants in modulation of gene expression in in vivo and in vitro in epilepsy models.
Topics: Animals; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Epilepsy; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Gene Expression Regulation; Genes, Reporter; Hippocampus; Kainic Acid; Male; Microscopy, Confocal; Neuropeptides; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures; Status Epilepticus; Transcription Factors | 2006 |
Forebrain-specific inactivation of Gq/G11 family G proteins results in age-dependent epilepsy and impaired endocannabinoid formation.
Topics: Age Factors; Animals; Cannabinoid Receptor Modulators; Endocannabinoids; Epilepsy; Excitatory Amino Acid Agonists; GTP-Binding Protein alpha Subunits, Gq-G11; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Prosencephalon; Protein Subunits | 2006 |
Not too excited? Thank your endocannabinoids.
Topics: Animals; Cannabinoid Receptor Modulators; Cell Death; Endocannabinoids; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Receptor, Cannabinoid, CB1 | 2006 |
The endocannabinoid system controls key epileptogenic circuits in the hippocampus.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoid Receptor Modulators; Endocannabinoids; Epilepsy; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; Hippocampus; Kainic Acid; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morpholines; Naphthalenes; Nerve Net; Pyramidal Cells; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Vesicular Glutamate Transport Protein 1 | 2006 |
Gastrodia elata modulated activator protein 1 via c-Jun N-terminal kinase signaling pathway in kainic acid-induced epilepsy in rats.
Topics: Animals; Anticonvulsants; Brain; Drugs, Chinese Herbal; Epilepsy; Gastrodia; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Male; Phosphorylation; Phytotherapy; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor AP-1 | 2007 |
The combined use of non-radioactive in situ hybridization and real-time RT-PCR to assess gene expression in cryosections.
Topics: Animals; Cell Communication; Cell Count; Connexin 43; Convulsants; Disease Models, Animal; Epilepsy; Gap Junctions; Gene Expression; Hippocampus; Image Cytometry; In Situ Hybridization; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Magnetic resonance imaging of the rat brain after epileptic seizures--preliminary results.
Topics: Animals; Brain; Diffusion Magnetic Resonance Imaging; Epilepsy; Kainic Acid; Rats; Rats, Wistar | 2006 |
Gender-based changes in cognition and emotionality in a new rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Emotions; Epilepsy; Female; Hippocampus; Kainic Acid; Male; Maze Learning; Neuromuscular Depolarizing Agents; Rats; Rats, Sprague-Dawley; Sex Characteristics | 2007 |
Kinetic changes and modulation by carbamazepine on voltage-gated sodium channels in rat CA1 neurons after epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Hippocampus; Kainic Acid; Male; Membrane Potentials; Neurons; Rats; Rats, Sprague-Dawley; Sodium Channels | 2006 |
Effect of ketogenic diet on hippocampus mossy fiber sprouting and GluR5 expression in kainic acid induced rat model.
Topics: 3-Hydroxybutyric Acid; Animals; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Ketone Bodies; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; RNA, Messenger | 2006 |
Taurine participates in the anticonvulsive effect of electroacupuncture.
Topics: Animals; Anticonvulsants; Electroacupuncture; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Membrane Glycoproteins; Membrane Transport Proteins; Rats; Rats, Wistar; Taurine | 2006 |
Kainic acid induces early and transient autophagic stress in mouse hippocampus.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Biomarkers; Epilepsy; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Molecular Chaperones; Nerve Degeneration; Neurotoxins; Oncogene Protein v-akt; Stress, Physiological; Ubiquitins; Up-Regulation | 2007 |
Preseizure increased gamma electroencephalographic activity has no effect on extracellular potassium or calcium.
Topics: Analysis of Variance; Animals; Brain; Calcium; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Extracellular Fluid; Kainic Acid; Male; Picrotoxin; Potassium; Rats; Rats, Sprague-Dawley; Spectrum Analysis | 2007 |
Altered excitability and distribution of NMDA receptor subunit proteins in cortical layers of rat pups following multiple perinatal seizures.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Cerebral Cortex; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Immunohistochemistry; Kainic Acid; Male; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Up-Regulation | 2007 |
Synaptic responses in superficial layers of medial entorhinal cortex from rats with kainate-induced epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Interneurons; Isoenzymes; Kainic Acid; Male; Neural Inhibition; Neural Pathways; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2007 |
Effect of oxcarbazepine pretreatment on convulsive activity and brain damage induced by kainic acid administration in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Male; Oxcarbazepine; Rats; Rats, Wistar | 2008 |
Limbic structures show altered glial-neuronal metabolism in the chronic phase of kainate induced epilepsy.
Topics: Animals; Carbon Isotopes; Chronic Disease; Epilepsy; Kainic Acid; Limbic System; Magnetic Resonance Spectroscopy; Male; Neuroglia; Neurons; Protons; Rats; Rats, Sprague-Dawley | 2008 |
Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols.
Topics: Administration, Oral; Animals; Anticonvulsants; Carbamazepine; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Epilepsy; Food, Fortified; Injections, Intraperitoneal; Kainic Acid; Male; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Seizures | 2007 |
Short-term changes in bilateral hippocampal coherence precede epileptiform events.
Topics: Animals; Brain Mapping; Diagnosis, Computer-Assisted; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL | 2007 |
Increased P-glycoprotein expression and decreased phenobarbital distribution in the brain of pentylenetetrazole-kindled rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Brain; Brain Chemistry; Cerebral Cortex; Convulsants; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Hypnotics and Sedatives; Kainic Acid; Kindling, Neurologic; Male; Muscarinic Agonists; Pentylenetetrazole; Phenobarbital; Pilocarpine; Rats; Rats, Sprague-Dawley; Rhodamine 123; Up-Regulation | 2007 |
IGF2 knockout mice are resistant to kainic acid-induced seizures and neurodegeneration.
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Epilepsy; Genetic Predisposition to Disease; Hippocampus; Insulin-Like Growth Factor II; Kainic Acid; Limbic System; Mice; Mice, Knockout; Nerve Degeneration; Neural Pathways; Neurotoxins; Organ Culture Techniques | 2007 |
Pyruvate protects against kainate-induced epileptic brain damage in rats.
Topics: Animals; Brain Damage, Chronic; Cell Death; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; HSP70 Heat-Shock Proteins; Kainic Acid; Male; Neocortex; Neurons; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Thalamus; Zinc | 2007 |
BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae.
Topics: Alternative Splicing; Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Dendrites; Epilepsy; Exons; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Neurons; Pilocarpine; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2008 |
Microarray profile of seizure damage-refractory hippocampal CA3 in a mouse model of epileptic preconditioning.
Topics: Animals; Brain Damage, Chronic; Convulsants; Disease Models, Animal; Down-Regulation; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Gene Expression Profiling; Hippocampus; Ischemic Preconditioning; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Status Epilepticus; Treatment Outcome; Up-Regulation | 2007 |
Increased expression of the lysosomal protease cathepsin S in hippocampal microglia following kainate-induced seizures.
Topics: Animals; Astrocytes; Cathepsins; Coloring Agents; Disease Models, Animal; Enzyme Activation; Epilepsy; Gene Expression Regulation, Enzymologic; Gliosis; Hippocampus; Kainic Acid; Lysosomes; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurotoxins; Nicotine; Nicotinic Agonists; Oligonucleotide Array Sequence Analysis; Pyramidal Cells; Up-Regulation | 2007 |
Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus.
Topics: Animals; Calpain; Caspases; Convulsants; Dipeptides; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Epilepsy; Fluoresceins; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Organic Chemicals; Rats; Rats, Wistar; Spectrin; Status Epilepticus; Time Factors | 2008 |
Acupuncture inhibits kainic Acid-induced hippocampal cell death in mice.
Topics: Acupuncture; Animals; Cell Death; Enzyme Activation; Epilepsy; Excitatory Amino Acid Agonists; Glutamate Decarboxylase; Hippocampus; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Neurotoxins; Proto-Oncogene Proteins c-fos | 2008 |
[The influence of myo-inositol on the ultrastructure of hippocampal CA1 area in kainate treated rats].
Topics: Animals; Anticonvulsants; Astrocytes; Epilepsy; Hippocampus; Inositol; Kainic Acid; Male; Neurons; Organelles; Rats; Synapses | 2007 |
Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats.
Topics: Aging; Animals; Antioxidants; Drug Resistance; Enzyme Activation; Epilepsy; Excitatory Amino Acid Agonists; Genetic Predisposition to Disease; Glutathione; Glutathione Peroxidase; Hippocampus; Kainic Acid; Lipid Peroxidation; Male; Nerve Degeneration; Neuroglia; Neurotoxins; Oxidative Stress; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Superoxide Dismutase; Superoxide Dismutase-1 | 2008 |
Autonomic consequences of kainic acid-induced limbic cortical seizures in rats: peripheral autonomic nerve activity, acute cardiovascular changes, and death.
Topics: Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Brain Ischemia; Cardiac Output, Low; Cerebral Cortex; Echocardiography; Electrocardiography; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Heart; Heart Rate; Hypothalamus; Kainic Acid; Limbic System; Male; Medulla Oblongata; Nitroprusside; Peripheral Nerves; Phenylephrine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 2008 |
Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus.
Topics: Algorithms; Animals; Blood-Brain Barrier; Chlorides; Chronic Disease; Contrast Media; Data Interpretation, Statistical; Dentate Gyrus; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Gadolinium; Gliosis; Kainic Acid; Magnetic Resonance Imaging; Male; Manganese Compounds; Mossy Fibers, Hippocampal; Nerve Degeneration; Rats; Rats, Wistar; Seizures; Status Epilepticus | 2008 |
Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats.
Topics: Acetylcholine; Acetylcholinesterase; Alternative Splicing; Animals; Chronic Disease; Convulsants; Electrophysiology; Entorhinal Cortex; Epilepsy; Gene Expression; Kainic Acid; Microelectrodes; Muscarinic Antagonists; Nicotinic Antagonists; Organ Culture Techniques; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Seizures | 2008 |
Variation in Galr1 expression determines susceptibility to exocitotoxin-induced cell death in mice.
Topics: Animals; Base Sequence; Cell Death; Epilepsy; Excitatory Amino Acid Agonists; Genetic Predisposition to Disease; Genetic Variation; Genomics; Haplotypes; Hippocampus; Kainic Acid; Male; Mice; Mice, Congenic; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Myelin Basic Protein; Nerve Tissue Proteins; Neurotoxins; Phenotype; Polymorphism, Single Nucleotide; Receptor, Galanin, Type 1; Species Specificity; Transcription Factors | 2008 |
Loss of astrocytic domain organization in the epileptic brain.
Topics: Amino Acids; Amyloid beta-Protein Precursor; Animals; Anticonvulsants; Astrocytes; Basic Helix-Loop-Helix Transcription Factors; Behavior, Animal; Brain; Dendrites; Disease Models, Animal; Electroencephalography; Epilepsy; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Kainic Acid; Luminescent Proteins; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Time Factors; Valproic Acid | 2008 |
Edaravone prevents kainic acid-induced neuronal death.
Topics: Aldehydes; Animals; Antipyrine; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Edaravone; Epilepsy; Free Radical Scavengers; Glutathione; Kainic Acid; Lipid Peroxidation; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Status Epilepticus; Treatment Outcome | 2008 |
Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice.
Topics: Amygdala; Animals; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Functional Laterality; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Microinjections; Nerve Tissue Proteins; Reaction Time; Statistics, Nonparametric; Time Factors | 2008 |
Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice.
Topics: Animals; Arousal; Carrier Proteins; Data Interpretation, Statistical; Electrodes, Implanted; Electroencephalography; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Fluorescent Antibody Technique; Homeostasis; Kainic Acid; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Patch-Clamp Techniques; Phenotype; Receptors, GABA-A; Sleep; Sleep Stages; Thalamus | 2008 |
A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Carbamates; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Fructose; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Time Factors; Topiramate; Video Recording | 2008 |
Blood flow compensates oxygen demand in the vulnerable CA3 region of the hippocampus during kainate-induced seizures.
Topics: Animals; Carbon Dioxide; Electrophysiology; Epilepsy; Hippocampus; Kainic Acid; Male; Oxygen; Rats; Rats, Inbred Strains; Regional Blood Flow | 1984 |
A multidisciplinary study of folic acid neurotoxicity: interactions with kainate binding sites and relevance to the aetiology of epilepsy.
Topics: Amygdala; Animals; Binding Sites; Binding, Competitive; Cerebral Cortex; Epilepsy; Folic Acid; Hippocampus; Kainic Acid; Male; Pyrrolidines; Rats; Rats, Inbred Strains | 1984 |
Infantile status epilepticus and future seizure susceptibility in the rat.
Topics: Age Factors; Animals; Disease Models, Animal; Disease Susceptibility; Epilepsy; Kainic Acid; Limbic System; Male; Rats; Rats, Inbred Strains; Recurrence; Status Epilepticus | 1984 |
Altered time course of changes in the hippocampal concentration of excitatory and inhibitory amino acids during kainate-induced epilepsy.
Topics: Amino Acids; Animals; Electrophysiology; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Time Factors | 1984 |
[Regional cerebral blood flow in limbic seizures induced by microinjection of kainic acid into amygdala in cats].
Topics: Amygdala; Animals; Cats; Cerebrovascular Circulation; Electroencephalography; Epilepsy; Kainic Acid; Limbic System; Microinjections; Models, Neurological; Pyrrolidines | 1984 |
[Effects of zinc sulfate on limbic motor epilepsy induced by kainic acid].
Topics: Animals; Epilepsy; Kainic Acid; Limbic System; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Sulfates; Zinc; Zinc Sulfate | 1984 |
The role of brain edema in epileptic brain damage induced by systemic kainic acid injection.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Convulsants; Epilepsy; Kainic Acid; Male; Pyrrolidines; Rats; Rats, Inbred Strains | 1984 |
Maturation of kainic acid seizure-brain damage syndrome in the rat. I. Clinical, electrographic and metabolic observations.
Topics: Animals; Brain; Brain Damage, Chronic; Electroencephalography; Epilepsy; Female; Glucose; Kainic Acid; Pyrrolidines; Rats; Rats, Inbred Strains | 1984 |
Maturation of kainic acid seizure-brain damage syndrome in the rat. III. Postnatal development of kainic acid binding sites in the limbic system.
Topics: Age Factors; Animals; Autoradiography; Binding Sites; Brain Damage, Chronic; Epilepsy; Hippocampus; Kainic Acid; Limbic System; Pyrrolidines; Rats | 1984 |
Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequelae.
Topics: Age Factors; Animals; Brain; Brain Damage, Chronic; Epilepsy; Hippocampus; Kainic Acid; Limbic System; Rats | 1984 |
Generalized epilepsy induced by kainic acid and anticonvulsant effect of N-aminomethylpiperazine-3,3-diethyl-2,4-pyridinedione.
Topics: Animals; Anticonvulsants; Cats; Electroencephalography; Epilepsy; Injections, Intraperitoneal; Injections, Subcutaneous; Kainic Acid; Male; Pyridones; Pyrrolidines; Rats; Rats, Inbred Strains | 1984 |
Seizure activity and lesions after intrahippocampal quinolinic acid injection.
Topics: Animals; Behavior, Animal; Brain; Electroencephalography; Epilepsy; Hippocampus; Injections; Kainic Acid; Male; Pyridines; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures | 1984 |
Electrophysiological mechanisms of kainic acid-induced epileptiform activity in the rat hippocampal slice.
Topics: Action Potentials; Animals; Epilepsy; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Neurons; Pyramidal Tracts; Pyrrolidines; Rats; Rats, Inbred Strains; Synapses | 1984 |
Injections of kainic acid into the amygdaloid complex of the rat: an electrographic, clinical and histological study in relation to the pathology of epilepsy.
Topics: Amygdala; Animals; Cerebral Cortex; Electroencephalography; Epilepsy; Hippocampus; Injections, Spinal; Kainic Acid; Pyrrolidines; Rats | 1980 |
On the relationship between kainic acid-induced epileptiform activity and hippocampal neuronal damage.
Topics: Action Potentials; Animals; Epilepsy; Hippocampus; Interneurons; Kainic Acid; Male; Neural Inhibition; Pyrrolidines; Rats | 1981 |
[Histochemical study of central nervous system lesions in experimental epilepsy caused by kainic acid].
Topics: Animals; Astrocytes; Brain; Electroencephalography; Epilepsy; Kainic Acid; Neurons; Rats; Rats, Inbred Strains | 1981 |
Spontaneously recurrent seizures after intracerebral injections of kainic acid in rat: a possible model of human temporal lobe epilepsy.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Epilepsy; Humans; Kainic Acid; Male; Pyrrolidines; Rats; Seizures; Stereotyped Behavior; Temporal Lobe | 1980 |
Epilepsy: changes in local glucose consumption and brain pathology produced by kainic acid.
Topics: Amygdala; Animals; Brain; Epilepsy; Glucose; Hippocampus; Injections; Kainic Acid; Pyrrolidines; Rats | 1981 |
Expression of Ca(2+)-ion permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors in Xenopus oocytes injected with total RNA from human epileptic temporal lobe.
Topics: Animals; Calcium; Epilepsy; Gene Expression; Humans; Kainic Acid; Oocytes; Receptors, AMPA; RNA; Temporal Lobe; Xenopus | 1995 |
Effect of kainate-induced seizure activity on the polyamine interconversion pathway in juvenile rat brain.
Topics: Acetylation; Age Factors; Animals; Cerebral Cortex; Epilepsy; Hippocampus; Kainic Acid; Polyamines; Rats; Rats, Sprague-Dawley; Seizures | 1995 |
NADPH diaphorase-containing nonpyramidal cells in the rat hippocampus exhibit differential sensitivity to kainic acid.
Topics: Animals; Cell Size; Epilepsy; Hippocampus; Kainic Acid; Male; NADPH Dehydrogenase; Neurons; Rats; Rats, Wistar; Sensitivity and Specificity | 1995 |
Gliosis and axonal sprouting in the hippocampus of epileptic rats are associated with an increase of tenascin-C immunoreactivity.
Topics: Animals; Astrocytes; Axons; Cell Death; Epilepsy; Gliosis; Hippocampus; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Male; Neurons; Rats; Rats, Wistar; Tenascin | 1995 |
Periodic acid-Schiff (PAS)-positive deposits in brain following kainic acid-induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood-brain barrier breakdown.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Mapping; Epilepsy; Extracellular Matrix; Gliosis; Immunohistochemistry; Kainic Acid; Male; Necrosis; Nerve Degeneration; Periodic Acid-Schiff Reaction; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Status Epilepticus | 1995 |
Correlation between seizure intensity and stress protein expression after limbic epilepsy in the rat brain.
Topics: Animals; Blotting, Western; Disease Models, Animal; Epilepsy; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Immunohistochemistry; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Seizures; Stress, Physiological; Temporal Lobe | 1995 |
Proliferative astrocytes may express fibronectin-like protein in the hippocampus of epileptic rats.
Topics: Animals; Astrocytes; Cell Division; Epilepsy; Fibronectins; Glial Fibrillary Acidic Protein; Hippocampus; Histocytochemistry; Kainic Acid; Male; Nerve Degeneration; Rats; Rats, Wistar; Thymidine | 1994 |
Kainate-induced apoptotic cell death in hippocampal neurons.
Topics: Animals; Apoptosis; Cell Nucleus; Diazepam; DNA; Electrophoresis, Polyacrylamide Gel; Epilepsy; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Microscopy, Electron; Neurons; Pyramidal Tracts; Rats; Rats, Wistar; Silver Staining | 1994 |
Hyperexcitability and cell loss in kainate-treated hippocampal slice cultures.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy; Evoked Potentials; Hippocampus; Immunohistochemistry; Interneurons; Kainic Acid; Nerve Fibers; Organ Culture Techniques; Parvalbumins; Pyramidal Cells; Somatostatin; Time Factors | 1993 |
Neonatal irradiation prevents the formation of hippocampal mossy fibers and the epileptic action of kainate on rat CA3 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicuculline; Electric Stimulation; Electrophysiology; Epilepsy; Gamma Rays; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; Nerve Fibers; Neurons, Afferent; Potassium; Pyramidal Cells; Quinoxalines; Rats; Rats, Wistar | 1994 |
Changes in oxygenation states of rat brain tissues during glutamate-related epileptic seizures--near-infrared study.
Topics: Animals; Brain; Dizocilpine Maleate; Electroencephalography; Electron Transport Complex IV; Epilepsy; Glutamates; Glutamic Acid; Hemoglobins; Kainic Acid; Male; N-Methylaspartate; Oxidation-Reduction; Oxygen; Rats; Rats, Wistar; Spectrophotometry, Infrared | 1994 |
Use of hippocampal slices to study mRNA changes in relation to synaptic plasticity.
Topics: Animals; Base Sequence; DNA-Binding Proteins; Early Growth Response Protein 1; Electric Stimulation; Epilepsy; Gene Expression; Hippocampus; Immediate-Early Proteins; In Situ Hybridization; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Male; Molecular Sequence Data; Neuronal Plasticity; Oligonucleotide Probes; Pyramidal Cells; Rats; Rats, Wistar; RNA, Messenger; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Transcription Factors; Zinc Fingers | 1994 |
Seizure-associated induction of basic fibroblast growth factor and its receptor in the rat brain.
Topics: Animals; Antibodies, Monoclonal; Astrocytes; Brain; Cerebral Cortex; Epilepsy; Fibroblast Growth Factor 2; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor; Reference Values; Seizures; Time Factors | 1994 |
Apoptosis associated DNA fragmentation in epileptic brain damage.
Topics: Amygdala; Animals; Apoptosis; Brain Diseases; DNA; Epilepsy; Hippocampus; Injections; Kainic Acid; Male; Rats; Rats, Wistar | 1994 |
Kainic acid, bicuculline, pentylenetetrazol and pilocarpine elicit maximal dentate activation in the anesthetized rat.
Topics: Anesthesia; Animals; Bicuculline; Convulsants; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; Kainic Acid; Male; Pentylenetetrazole; Pilocarpine; Rats; Rats, Sprague-Dawley | 1994 |
Serum domoic acid clearance and clinical observations in the cynomolgus monkey and Sprague-Dawley rat following a single i.v. dose.
Topics: Animals; Epilepsy; Female; Injections, Intravenous; Kainic Acid; Macaca fascicularis; Rats; Rats, Sprague-Dawley; Species Specificity; Time Factors; Vomiting | 1994 |
Effects of the epileptogenic agent bicuculline methiodide on membrane currents induced by N-methyl-D-aspartate and kainate (oocyte; Xenopus laevis).
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Electric Conductivity; Epilepsy; Kainic Acid; N-Methylaspartate; Oocytes; Xenopus laevis | 1994 |
NCAM immunoreactivity on mossy fibers and reactive astrocytes in the hippocampus of epileptic rats.
Topics: Afferent Pathways; Animals; Astrocytes; Blotting, Western; Cell Adhesion Molecules, Neuronal; Epilepsy; Hippocampus; Immunoenzyme Techniques; Kainic Acid; Male; Microscopy, Electron; Nerve Fibers; Rats; Rats, Wistar | 1993 |
Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia.
Topics: Animals; Base Sequence; Brain Ischemia; Disease Susceptibility; Epilepsy; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Molecular Sequence Data; Neurons; Oligonucleotide Probes; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Tissue Distribution | 1993 |
Epilepsy induced collateral sprouting of hippocampal mossy fibers: does it induce the development of ectopic synapses with granule cell dendrites?
Topics: Animals; Dendrites; Epilepsy; Golgi Apparatus; Granulocytes; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Microscopy, Electron; Nerve Fibers; Rats; Rats, Wistar; Synapses | 1993 |
EEG evaluation of the anticonvulsive effect of dapsone in the kainic acid model of epilepsy.
Topics: Animals; Anticonvulsants; Dapsone; Electrodes, Implanted; Electroencephalography; Epilepsy; Kainic Acid; Male; Rats; Rats, Wistar | 1993 |
Mossy fiber sprouting in epileptic rats is associated with a transient increased expression of alpha-tubulin.
Topics: Amygdala; Animals; Epilepsy; Hippocampus; Kainic Acid; Limbic System; Male; Nerve Fibers; Rats; Rats, Wistar; RNA, Messenger; Seizures; Time Factors; Tubulin | 1993 |
Reactive astrocytes in the kainic acid-damage hippocampus have the phenotypic features of type-2 astrocytes.
Topics: Animals; Antibodies, Monoclonal; Astrocytes; Epilepsy; Fluorescent Antibody Technique; GAP-43 Protein; Glial Fibrillary Acidic Protein; Hippocampus; Immunoenzyme Techniques; Kainic Acid; Membrane Glycoproteins; Nerve Tissue Proteins; Phenotype; Rats; Rats, Wistar | 1993 |
Induction of c-fos and reduction of dynorphin in dentate granule cells of a rat model of epilepsy produced by systemic administration of kainic acid: an immunohistochemical study.
Topics: Animals; Behavior, Animal; Dentate Gyrus; Dynorphins; Epilepsy; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Limbic System; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 1995 |
Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainate-treated epileptic rats.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Rats; Time Factors | 1996 |
Studies of qingyangshen (I): Differential expression of hippocampal c-fos proto-oncogene during kainic acid induced acute and chronic seizures.
Topics: Animals; Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Gene Expression; Genes, fos; Hippocampus; Kainic Acid; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger | 1995 |
Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents.
Topics: Acetates; Acetic Acid; Analgesics; Analysis of Variance; Animals; Anticonvulsants; Body Temperature; Central Nervous System; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Ethanol; Excitatory Amino Acid Agonists; Kainic Acid; Male; Medicine, African Traditional; Mice; Pentylenetetrazole; Plant Extracts; Plant Leaves; Plants, Medicinal; Poisoning; Rats; Rats, Wistar; Seizures | 1996 |
Antiepileptic effects of acidic fibroblast growth factor examined in kainic acid-mediated seizures in the rat.
Topics: Analysis of Variance; Animals; Epilepsy; Fibroblast Growth Factors; Kainic Acid; Rats; Rats, Sprague-Dawley; Seizures | 1996 |
7-chlorokynurenic acid prevents in vitro epileptiform and neurotoxic effects due to kainic acid.
Topics: Animals; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1996 |
Synergistic action of corticosterone on kainic acid-induced electrophysiological alterations in the hippocampus.
Topics: Animals; Corticosterone; Drug Synergism; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred BALB C; Mifepristone; Neurotoxins | 1995 |
[Changes of amino acids release in rat's hippocampus during kainic acid induced epilepsy and acupuncture].
Topics: Amino Acids; Animals; Electroacupuncture; Epilepsy; Female; Hippocampus; Kainic Acid; Male; Rats; Rats, Wistar | 1995 |
[The effects of single administration of kainic acid on cellular signal transmission pathway and susceptibility to seizure].
Topics: Animals; Disease Susceptibility; Enkephalins; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Genes, fos; Genes, jun; Kainic Acid; Kindling, Neurologic; Male; Protein Precursors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 1995 |
Cellular localization of neuropeptide-Y receptors in the rat hippocampus: long-term effects of limbic seizures.
Topics: Animals; Autoradiography; Convulsants; Epilepsy; Hippocampus; Interneurons; Kainic Acid; Male; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Time Factors | 1996 |
A role for synaptic and network plasticity in controlling epileptiform activity in CA1 in the kainic acid-lesioned rat hippocampus in vitro.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Neuronal Plasticity; Rats; Rats, Wistar; Synaptic Transmission | 1996 |
Widespread ectopic neuropeptide-Y immunoreactivity in contralateral mossy fibres after a unilateral intrahippocampal kainic acid injection in the rat.
Topics: Animals; Antibody Specificity; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Microinjections; Neuropeptide Y; Rats; Rats, Wistar | 1996 |
Spontaneous and stimulation-induced synchronized burst afterdischarges in the isolated CA1 of kainate-treated rats.
Topics: Action Potentials; Animals; Behavior, Animal; Bicuculline; Cell Count; Convulsants; Dentate Gyrus; Epilepsy; Injections; Kainic Acid; Male; Neurons; Perfusion; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1996 |
Microglial activation by epileptic activities through the propagation pathway of kainic acid-induced hippocampal seizures in the rat.
Topics: Animals; Convulsants; Epilepsy; Hippocampus; Kainic Acid; Male; Microglia; Neural Pathways; Rats; Rats, Sprague-Dawley | 1996 |
Functional activation of somatostatin- and neuropeptide Y-containing neurons in the entorhinal cortex of chronically epileptic rats.
Topics: Animals; Cell Count; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Male; Neurons; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Somatostatin; Synaptic Transmission | 1996 |
The calretinin-containing mossy cells survive excitotoxic insult in the gerbil dentate gyrus. Comparison of excitotoxicity-induced neuropathological changes in the gerbil and rat.
Topics: Animals; Calbindin 2; Cell Survival; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Gerbillinae; Immunohistochemistry; Ischemic Attack, Transient; Kainic Acid; Male; Nerve Fibers; Nerve Tissue Proteins; Neurons; Neurotoxins; Rats; Rats, Wistar; S100 Calcium Binding Protein G; Somatostatin | 1996 |
Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy.
Topics: Animals; Coloring Agents; Dendrites; Dentate Gyrus; Epilepsy; Hippocampus; Humans; Kainic Acid; Nerve Regeneration; Neurofibrils; Rats; Receptors, AMPA; Synaptic Transmission; Up-Regulation | 1996 |
Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats.
Topics: Age Factors; Animals; Cell Count; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Functional Laterality; Hippocampus; Humans; Kainic Acid; Male; Nerve Regeneration; Neurofibrils; Rats; Rats, Sprague-Dawley | 1996 |
Comparison of seizure related amino acid release in human epileptic hippocampus versus a chronic, kainate rat model of hippocampal epilepsy.
Topics: Amino Acids; Animals; Electroencephalography; Epilepsy; Excitatory Amino Acids; gamma-Aminobutyric Acid; Hippocampus; Humans; Kainic Acid; Microdialysis; Rats; Rats, Sprague-Dawley; Taurine | 1996 |
Axonal sprouting of CA1 pyramidal cells in hyperexcitable hippocampal slices of kainate-treated rats.
Topics: Animals; Axons; Electrophysiology; Epilepsy; Hippocampus; In Vitro Techniques; Kainic Acid; Lysine; Male; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1996 |
Blockade of pilocarpine- or kainate-induced mossy fiber sprouting by cycloheximide does not prevent subsequent epileptogenesis in rats.
Topics: Animals; Cycloheximide; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Male; Muscarinic Agonists; Nerve Fibers; Pilocarpine; Protein Synthesis Inhibitors; Rats; Rats, Wistar | 1997 |
Altered expression of NPY-Y1 receptors in kainic acid induced epilepsy in rats.
Topics: Animals; Autoradiography; Dentate Gyrus; Epilepsy; Hippocampus; Iodine Radioisotopes; Kainic Acid; Male; Neurons; Peptide YY; Peptides; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; RNA, Messenger; Time Factors; Transcription, Genetic | 1997 |
Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats.
Topics: Action Potentials; Animals; Axons; Behavior, Animal; Cholecystokinin; Coloring Agents; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Male; Neurons; Nissl Bodies; Parvalbumins; Rats; Somatostatin; Staining and Labeling | 1997 |
Astrocytes may contribute to the latent period in progressive neuron loss, axon sprouting, and chronic seizures in rat kainate hippocampal epilepsy.
Topics: Animals; Astrocytes; Axons; Cell Count; Epilepsy; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Nerve Regeneration; Rats; Rats, Sprague-Dawley | 1996 |
Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Cells, Cultured; Electric Stimulation; Electroencephalography; Embryo, Mammalian; Epilepsy; Evoked Potentials; Female; Functional Laterality; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Kainic Acid; Receptors, Presynaptic; Synaptic Transmission; Tetrodotoxin | 1997 |
Knock-out mice reveal a critical antiepileptic role for neuropeptide Y.
Topics: Action Potentials; Animals; Convulsants; Electroencephalography; Epilepsy; Gene Expression Regulation; Genotype; Hippocampus; Kainic Acid; Mice; Mice, Knockout; Neuropeptide Y; Perforant Pathway; Seizures; Synaptic Transmission | 1997 |
Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysiology; Epilepsy; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Humans; In Vitro Techniques; Kainic Acid; Male; Motor Activity; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Values | 1998 |
Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain.
Topics: Animals; Brain; Brain Mapping; Epilepsy; ErbB Receptors; Glycoproteins; Hippocampus; In Situ Hybridization; Kainic Acid; Locomotion; Long-Term Potentiation; Male; Motor Activity; Motor Cortex; Neuregulins; Neuronal Plasticity; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptor, ErbB-3; Receptor, ErbB-4; Tetany | 1998 |
Upregulation of L-type Ca2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Astrocytes; Brain Injuries; Brain Ischemia; Calcium Channels; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Gerbillinae; Glial Fibrillary Acidic Protein; Gliosis; Homeostasis; Hot Temperature; Injections, Intraventricular; Kainic Acid; Male; Mice; Mice, Neurologic Mutants; Myelin Sheath; Rats; Up-Regulation; Wounds, Stab | 1998 |
Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Cell Count; Cell Division; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Injections, Intraventricular; Kainic Acid; Male; Neuroglia; Neurons; Rats; Rats, Wistar; Stem Cells | 1998 |
Kainic acid-induced perirhinal cortical seizures in rats.
Topics: Amygdala; Animals; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Male; Microinjections; Motor Cortex; Rats; Rats, Wistar; Somatosensory Cortex | 1998 |
Carbon monoxide regulates cerebral blood flow in epileptic seizures but not in hypercapnia.
Topics: Animals; Carbon Dioxide; Carbon Monoxide; Cerebrovascular Circulation; Electroencephalography; Enzyme Inhibitors; Epilepsy; Half-Life; Heme Oxygenase (Decyclizing); Hydrogen-Ion Concentration; Hypercapnia; Kainic Acid; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Protoporphyrins; Rats; Rats, Wistar | 1998 |
Androgenic neurosteroids: anti-seizure effects in an animal model of epilepsy.
Topics: Anabolic Agents; Androstane-3,17-diol; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Escape Reaction; Female; Hippocampus; Injections, Subcutaneous; Kainic Acid; Maze Learning; Mental Recall; Ovariectomy; Rats; Rats, Long-Evans | 1998 |
Nurr1 mRNA expression in neonatal and adult rat brain following kainic acid-induced seizure activity.
Topics: Age Factors; Animals; Animals, Newborn; Brain Chemistry; DNA-Binding Proteins; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation, Developmental; In Situ Hybridization; Kainic Acid; Male; Nerve Tissue Proteins; Nuclear Receptor Subfamily 4, Group A, Member 2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Synapses; Transcription Factors | 1998 |
Long-lasting enhanced expression in the rat hippocampus of NMDAR1 splice variants in a kainate model of epilepsy.
Topics: Animals; Epilepsy; Excitatory Amino Acid Agonists; Exons; Hippocampus; In Situ Hybridization; In Vitro Techniques; Kainic Acid; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stimulation, Chemical | 1998 |
[Seizure-linked hippocampal plasticity and protection against excitotoxicity: possible role of neuropeptide-y].
Topics: Animals; Cell Count; Epilepsy; Hippocampus; Immunohistochemistry; Kainic Acid; Mossy Fibers, Hippocampal; Neuronal Plasticity; Neuropeptide Y; Pyramidal Cells; Rats; Rats, Wistar | 1998 |
Supragranular mossy fiber sprouting is not necessary for spontaneous seizures in the intrahippocampal kainate model of epilepsy in the rat.
Topics: Animals; Cycloheximide; Disease Models, Animal; Electroencephalography; Epilepsy; Evoked Potentials; GAP-43 Protein; Hippocampus; Kainic Acid; Nerve Fibers; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Seizures; Transcription, Genetic | 1998 |
Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy.
Topics: Animals; beta-Galactosidase; Brain Ischemia; Cell Survival; Cerebrovascular Disorders; Epilepsy; Genetic Therapy; Genetic Vectors; Heat-Shock Proteins; Hippocampus; HSP72 Heat-Shock Proteins; Kainic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Reference Values; Simplexvirus; Time Factors | 1998 |
Residual granule cells can maintain susceptibility of CA3 pyramidal cells to kainate-induced epileptiform discharges.
Topics: Action Potentials; Animals; Cell Count; Drug Resistance; Electrophysiology; Epilepsy; Extracellular Space; Hippocampus; In Vitro Techniques; Intracellular Membranes; Kainic Acid; Membrane Potentials; Pyramidal Cells; Rats; Rats, Long-Evans | 1998 |
PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat.
Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Diazepam; Epilepsy; Hippocampus; Kainic Acid; Lamotrigine; Male; Neuroprotective Agents; Rats; Rats, Wistar; Triazines | 1998 |
A gene expression approach to mapping the functional maturation of the hippocampus.
Topics: Animals; Brain Mapping; Denervation; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Genes, Immediate-Early; Genes, Reporter; Glutamic Acid; Kainic Acid; Lac Operon; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-fos; Pyramidal Cells; Signal Transduction | 1998 |
NMDAR2 upregulation precedes mossy fiber sprouting in kainate rat hippocampal epilepsy.
Topics: Animals; Epilepsy; Hippocampus; Kainic Acid; Male; Mossy Fibers, Hippocampal; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Up-Regulation | 1998 |
Abnormal targeting of developing hippocampal mossy fibers after epileptiform activities via L-type Ca2+ channel activation in vitro.
Topics: Animals; Animals, Newborn; Calcium Channel Blockers; Calcium Channels; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Kainic Acid; Microscopy, Confocal; Mossy Fibers, Hippocampal; Picrotoxin; Rats; Rats, Wistar; Synaptic Transmission; Tetrodotoxin | 1999 |
Prolonged expression of zinc finger immediate-early gene mRNAs and decreased protein synthesis following kainic acid induced seizures.
Topics: Amygdala; Animals; Cerebral Cortex; Dentate Gyrus; DNA-Binding Proteins; Early Growth Response Protein 1; Early Growth Response Protein 2; Early Growth Response Protein 3; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation; Genes, Immediate-Early; Glutamic Acid; Immediate-Early Proteins; In Situ Hybridization; Kainic Acid; Male; Nerve Tissue Proteins; Nuclear Receptor Subfamily 4, Group A, Member 1; Nuclear Receptor Subfamily 4, Group A, Member 2; Oligonucleotide Probes; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Transcription Factors; Zinc Fingers | 1999 |
Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?
Topics: Amygdala; Animals; Apoptosis; Biomarkers; Brain Ischemia; Cell Cycle; Cell Nucleus; Cyclin D1; Cyclin D2; Cyclin D3; Cyclins; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Nerve Degeneration; Neurons; Neurotoxins; Prosencephalon; Rats; Rats, Wistar; RNA, Messenger; Time Factors | 1999 |
Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Brain; Brain Chemistry; Carrier Proteins; Cell Death; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Gene Expression Regulation, Developmental; Glutamate Plasma Membrane Transport Proteins; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neuroglia; Neuronal Plasticity; Neurons; Oligonucleotide Probes; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; RNA, Messenger; Symporters; Tritium | 1999 |
Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation.
Topics: Age Factors; Animals; Cells, Cultured; Cerebellum; Cerebral Cortex; DNA Primers; Epilepsy; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation, Developmental; GluK2 Kainate Receptor; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neuroglia; Neurons; Olfactory Bulb; Potassium; Pregnancy; Rats; Rats, Wistar; Receptors, Kainic Acid; RNA Editing; RNA, Messenger | 1999 |
Effect of seizures on cerebral hypoxic-ischemic lesions in immature rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain Ischemia; Convulsants; Epilepsy; Excitatory Amino Acid Agonists; Female; Flurothyl; Hippocampus; Hypoxia, Brain; Kainic Acid; Pregnancy; Rats; Rats, Wistar | 1999 |
Autoradiographic reevaluation of the binding properties of 125I-[Leu31,Pro34]peptide YY and 125I-peptide YY3-36 to neuropeptide Y receptor subtypes in rat forebrain.
Topics: Animals; Autoradiography; Brain Chemistry; Epilepsy; Excitatory Amino Acid Agonists; Gastrointestinal Hormones; Iodine Radioisotopes; Kainic Acid; Male; Peptide Fragments; Peptide YY; Prosencephalon; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y | 1999 |
Interneurons and the ghost of the sea.
Topics: Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Kainic Acid; Pyramidal Cells; Receptors, Kainic Acid | 1998 |
Altered mitochondrial oxidative phosphorylation in hippocampal slices of kainate-treated rats.
Topics: Animals; Benzimidazoles; Calcium; Chelating Agents; Coloring Agents; Disease Models, Animal; Egtazic Acid; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mitochondria; NADP; Neurons; Organ Culture Techniques; Oxidative Phosphorylation; Oxygen Consumption; Potassium Chloride; Rats; Rats, Sprague-Dawley; Ruthenium Red; Sodium-Potassium-Exchanging ATPase; Uncoupling Agents | 1999 |
Kainic and domoic acids differentially affect NADPH-diaphorase neurons in the mouse hippocampal formation.
Topics: Animals; Brain Chemistry; Corpus Striatum; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Mice; NADPH Dehydrogenase; Neuromuscular Depolarizing Agents; Neurons; Neurotoxins; Parietal Lobe | 1999 |
Interleukin-1beta immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures.
Topics: Animals; Antibodies; Anticonvulsants; Antirheumatic Agents; Bicuculline; Cell Count; Electroencephalography; Enzyme-Linked Immunosorbent Assay; Epilepsy; Excitatory Amino Acid Agonists; GABA Antagonists; Glutamic Acid; Hippocampus; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Kainic Acid; Male; Microglia; Nerve Degeneration; Neurons; Piperazines; Rats; Rats, Sprague-Dawley; Sialoglycoproteins | 1999 |
Hippocampal alterations of apolipoprotein E and D mRNA levels in vivo and in vitro following kainate excitotoxicity.
Topics: Animals; Apolipoproteins; Apolipoproteins D; Apolipoproteins E; DNA Fragmentation; Epilepsy; Hippocampus; Kainic Acid; Male; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; RNA, Messenger | 1999 |
Increased NR1-NR2A/B coassembly as a mechanism for rat chronic hippocampal epilepsy.
Topics: Animals; Chronic Disease; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1999 |
Consequences of cortical dysplasia during development in rats.
Topics: Amygdala; Animals; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Epilepsy; Freezing; Functional Laterality; Hippocampus; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Mossy Fibers, Hippocampal; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques | 1999 |
Changes in hippocampal and cortical B1 bradykinin receptor biological activity in two experimental models of epilepsy.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Cerebral Cortex; Electric Stimulation; Epilepsy; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Kallidin; Kindling, Neurologic; Male; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin | 1999 |
Abnormal responses to perforant path stimulation in the dentate gyrus of slices from rats with kainate-induced epilepsy and mossy fiber reorganization.
Topics: Action Potentials; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysiology; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Kainic Acid; Male; Mossy Fibers, Hippocampal; Neuronal Plasticity; Perforant Pathway; Rats; Rats, Sprague-Dawley; Staining and Labeling | 1999 |
Alterations of perisomatic GABA synapses on hippocampal CA1 inhibitory interneurons and pyramidal cells in the kainate model of epilepsy.
Topics: Animals; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Interneurons; Kainic Acid; Male; Microscopy, Electron; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses | 1999 |
EPR imaging for in vivo analysis of the half-life of a nitroxide radical in the hippocampus and cerebral cortex of rats after epileptic seizures.
Topics: Animals; Cerebral Cortex; Electron Spin Resonance Spectroscopy; Epilepsy; Free Radicals; Half-Life; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Male; Nitrogen Oxides; Rats; Rats, Wistar | 1999 |
Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex.
Topics: Age Factors; Animals; Avoidance Learning; Behavior, Animal; Blotting, Northern; Brain Chemistry; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Hot Temperature; In Situ Hybridization; Kainic Acid; Long-Term Potentiation; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Neuronal Plasticity; Organ Culture Techniques; Pain Threshold; RNA, Messenger; Swimming; Transgenes | 1999 |
Assessment of inhibition and epileptiform activity in the septal dentate gyrus of freely behaving rats during the first week after kainate treatment.
Topics: Animals; Dentate Gyrus; Electroencephalography; Epilepsy; Excitatory Postsynaptic Potentials; Functional Laterality; Kainic Acid; Male; Neurons; Perforant Pathway; Rats; Rats, Sprague-Dawley; Time Factors | 1999 |
Maturation of kainate-induced epileptiform activities in interconnected intact neonatal limbic structures in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Benzodiazepines; Calcium; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Limbic System; Male; Organ Culture Techniques; Potassium; Rats; Rats, Wistar; Septal Nuclei; Synapses; Tetrodotoxin | 1999 |
Anticonvulsive and free radical scavenging actions of two herbs, Uncaria rhynchophylla (MIQ) Jack and Gastrodia elata Bl., in kainic acid-treated rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Drug Combinations; Drug Synergism; Drugs, Chinese Herbal; Electroencephalography; Electromyography; Epilepsy; Free Radical Scavengers; Free Radicals; Kainic Acid; Lipid Peroxidation; Lipid Peroxides; Male; Medicine, Chinese Traditional; Plants, Medicinal; Rats; Rats, Sprague-Dawley | 1999 |
Upregulation of GABA neurotransmission suppresses hippocampal excitability and prevents long-term potentiation in transgenic superoxide dismutase-overexpressing mice.
Topics: Animals; Electrophysiology; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Humans; In Vitro Techniques; Isoenzymes; Kainic Acid; Long-Term Potentiation; Mice; Mice, Transgenic; Neural Inhibition; Patch-Clamp Techniques; Superoxide Dismutase; Synaptic Transmission; Up-Regulation | 1999 |
Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels.
Topics: Animals; Disease Models, Animal; DNA Fragmentation; Epilepsy; Glyburide; Hippocampus; In Situ Nick-End Labeling; Ischemic Attack, Transient; Ischemic Preconditioning; Kainic Acid; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Phenylisopropyladenosine; Potassium Channels; Purinergic P1 Receptor Antagonists; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Purinergic P1; Time Factors; Xanthines | 1999 |
Increased sensitivity to seizures in mice lacking cellular prion protein.
Topics: Animals; Disease Models, Animal; Epilepsy; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Knockout; Pentylenetetrazole; Pilocarpine; PrPC Proteins; Seizures | 1999 |
Nuclear factor kappa B-mediated kainate neurotoxicity in the rat and hamster hippocampus.
Topics: Animals; Cell Death; Cell Nucleus; Cricetinae; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Kainic Acid; Mesocricetus; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; NF-kappa B; Rats; Rats, Sprague-Dawley | 1999 |
Immunohistochemical analysis on the role of adenosine A1 receptors in epilepsy.
Topics: Animals; Cell Count; CHO Cells; Chronic Disease; Cricetinae; Electrodes, Implanted; Epilepsy; Female; Hippocampus; Immunohistochemistry; Kainic Acid; Kindling, Neurologic; Male; Molecular Weight; Mossy Fibers, Hippocampal; Purinergic P1 Receptor Agonists; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Purinergic P1; Time Factors | 1999 |
Ionotropic glutamate and GABA receptors in human epileptic neocortical tissue: quantitative in vitro receptor autoradiography.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Autoradiography; Binding Sites; Dizocilpine Maleate; Epilepsy; Female; Humans; Kainic Acid; Male; Muscimol; Neocortex; Receptors, AMPA; Receptors, GABA-A; Receptors, Glutamate; Tissue Distribution | 1999 |
Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission.
Topics: 3-Hydroxybutyric Acid; 4-Aminopyridine; Acetoacetates; Animals; Cells, Cultured; Diet; Entorhinal Cortex; Epilepsy; Evoked Potentials; Excitatory Amino Acid Agonists; Fasting; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Kainic Acid; Ketosis; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, GABA-A; Receptors, Glycine; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Synaptic Membranes; Synaptic Transmission | 2000 |
Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid-treated rats.
Topics: Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; Magnesium; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 2000 |
Genetic dissection of the signals that induce synaptic reorganization.
Topics: Animals; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; GAP-43 Protein; Gene Expression; In Situ Hybridization; Kainic Acid; Kindling, Neurologic; Male; Mice; Mice, Inbred C57BL; Mossy Fibers, Hippocampal; Nerve Degeneration; Proto-Oncogene Proteins c-fos; RNA, Messenger; Seizures; Signal Transduction; Species Specificity; Synapses | 2000 |
Amino acid neurotransmitter metabolism in neurones and glia following kainate injection in rats.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Kainic Acid; Male; Neuroglia; Neurons; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 2000 |
CNS oxidative stress associated with the kainic acid rodent model of experimental epilepsy.
Topics: Animals; Cerebellum; Cerebral Cortex; Epilepsy; Excitatory Amino Acid Agonists; Glutathione; Glutathione Disulfide; Hippocampus; Kainic Acid; Male; Oxidative Stress; Rats; Rats, Inbred F344; Thiobarbituric Acid Reactive Substances | 2000 |
Spatio-temporal profile of DNA fragmentation and its relationship to patterns of epileptiform activity following focally evoked limbic seizures.
Topics: Animals; Cell Death; Disease Models, Animal; DNA Fragmentation; Electroencephalography; Epilepsy; Excitatory Amino Acid Agonists; Functional Laterality; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Rats; Rats, Sprague-Dawley | 2000 |
Anti-seizure effects of progesterone and 3alpha,5alpha-THP in kainic acid and perforant pathway models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Epilepsy; Female; Kainic Acid; Ovariectomy; Perforant Pathway; Pregnanolone; Progesterone; Rats; Rats, Long-Evans | 2000 |
Permanent reduction of seizure threshold in post-ischemic CA3 pyramidal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain Ischemia; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Patch-Clamp Techniques; Periodicity; Potassium; Pyramidal Cells; Rats; Rats, Wistar; Seizures; Stimulation, Chemical; Synapses; Time Factors | 2000 |
Optical recording study of granule cell activities in the hippocampal dentate gyrus of kainate-treated rats.
Topics: Animals; Dentate Gyrus; Electric Stimulation; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; Mossy Fibers, Hippocampal; Neural Inhibition; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A; Synapses | 2000 |
NMDAR1 receptor proteins and mossy fibers in the fascia dentata during rat kainate hippocampal epileptogenesis.
Topics: Animals; Cell Count; Densitometry; Dentate Gyrus; Epilepsy; Hippocampus; Histocytochemistry; Immunohistochemistry; Kainic Acid; Linear Models; Male; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2000 |
Temporal progression of kainic acid induced neuronal and myelin degeneration in the rat forebrain.
Topics: Amygdala; Animals; Basal Ganglia; Coloring Agents; Denervation; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Female; Fluorescent Dyes; Glutamic Acid; Hippocampus; Hypothalamus; Kainic Acid; Myelin Sheath; Nerve Degeneration; Neurons; Neurotoxins; Olfactory Pathways; Parietal Lobe; Phosphates; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Status Epilepticus; Thalamus; Time Factors | 2000 |
Expression of metabotropic glutamate receptor 5 is increased in astrocytes after kainate-induced epileptic seizures.
Topics: Amygdala; Animals; Astrocytes; Epilepsy; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; RNA, Messenger | 2000 |
Kainic acid induces distinct types of epileptiform discharge with differential involvement of hippocampus and neocortex.
Topics: Animals; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Neocortex; Rats; Rats, Sprague-Dawley; Seizures | 2000 |
The salt-inducible kinase, SIK, is induced by depolarization in brain.
Topics: Animals; Blotting, Northern; Cerebral Cortex; Colforsin; Cycloheximide; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Genes, Immediate-Early; Hippocampus; Kainic Acid; Membrane Potentials; Molecular Sequence Data; Neurons; PC12 Cells; Phylogeny; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Salts; Seizures; Sequence Homology, Amino Acid; Serine; src-Family Kinases | 2000 |
Interruption of supramammillohippocampal afferents prevents the genesis and spread of limbic seizures in the hippocampus via a disinhibition mechanism.
Topics: Afferent Pathways; Amygdala; Animals; Behavior, Animal; Denervation; Electroencephalography; Entorhinal Cortex; Epilepsy; GABA-A Receptor Antagonists; Hippocampus; Hypothalamus; Kainic Acid; Male; Muscimol; Neural Inhibition; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, GABA-A | 2000 |
Temporal changes in expression of neuronal nitric oxide synthase mRNA in the rat hippocampus associated with kainate-induced seizures.
Topics: Animals; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; In Situ Hybridization; Kainic Acid; Male; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 2000 |
Seizures and sensory stimulation result in different patterns of brain derived neurotrophic factor protein expression in the barrel cortex and hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Convulsants; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Hippocampus; Kainic Acid; Male; Neuronal Plasticity; Pentylenetetrazole; Physical Stimulation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Somatosensory Cortex; Touch; Vibrissae | 2000 |
Decreased levels of neuropeptide Y(5) receptor binding sites in two experimental models of epilepsy.
Topics: Animals; Cerebral Cortex; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y | 2000 |
Chronic brain oxidation in a glutathione peroxidase knockout mouse model results in increased resistance to induced epileptic seizures.
Topics: Animals; Brain; Cell Death; Disease Models, Animal; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Antagonists; Glutathione Peroxidase; In Situ Nick-End Labeling; In Vitro Techniques; Kainic Acid; Mice; Mice, Inbred Strains; Mice, Knockout; Neurons; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Sulfhydryl Compounds | 2000 |
Long-term consequences of early postnatal seizures on hippocampal learning and plasticity.
Topics: Age Factors; Animals; Animals, Newborn; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Kainic Acid; Kindling, Neurologic; Long-Term Potentiation; Male; Maze Learning; Memory; Neural Inhibition; Neuronal Plasticity; Rats; Seizures; Space Perception | 2000 |
Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice.
Topics: Animals; Apoptosis; Astrocytes; Caspase 1; Caspase 3; Caspases; DNA, Single-Stranded; Epilepsy; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Granulocyte-Macrophage Colony-Stimulating Factor; Hippocampus; In Situ Nick-End Labeling; Kainic Acid; Male; Malondialdehyde; Metallothionein; Metallothionein 3; Mice; Mice, Inbred Strains; Mice, Knockout; Microglia; Nerve Degeneration; Nerve Tissue Proteins; NF-kappa B; Nitrogen; Oxidative Stress; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Seizures; Superoxide Dismutase; Tyrosine; Zinc | 2000 |
Plasticity of excitatory amino acid transporters in experimental epilepsy.
Topics: Animals; Dicarboxylic Acids; Epilepsy; Female; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; Neuronal Plasticity; Neurotransmitter Uptake Inhibitors; Pilocarpine; Propionates; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Up-Regulation; Veratridine | 2000 |
Plastic changes in neuropeptide Y receptor subtypes in experimental models of limbic seizures.
Topics: Animals; Anticonvulsants; Arginine; Blotting, Western; Electroencephalography; Epilepsy; Hippocampus; Injections, Intraventricular; Kainic Acid; Kindling, Neurologic; Limbic System; Male; Neuronal Plasticity; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y | 2000 |
Chronic epileptogenesis requires development of a network of pathologically interconnected neuron clusters: a hypothesis.
Topics: Action Potentials; Animals; Chronic Disease; Dentate Gyrus; Epilepsies, Partial; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Models, Neurological; Neural Pathways; Neuronal Plasticity; Rats; Rats, Sprague-Dawley | 2000 |
Long-term increase of GluR2 alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor subunit in the dispersed dentate gyrus after intrahippocampal kainate injection in the mouse.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Kainic Acid; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurodegenerative Diseases; Neuronal Plasticity; Neurons; Rats; Rats, Wistar; Receptors, AMPA; Time Factors | 2000 |
Expression of connexin genes in hippocampus of kainate-treated and kindled rats under conditions of experimental epilepsy.
Topics: Animals; Blotting, Northern; Connexin 30; Connexin 43; Connexins; Epilepsy; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique; Gap Junction beta-1 Protein; Gap Junction delta-2 Protein; Gap Junctions; Gene Expression; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2000 |
A role for sodium and chloride in kainic acid-induced beading of inhibitory interneuron dendrites.
Topics: Animals; Calcium; Chloride Channels; Chlorides; Dendrites; Dose-Response Relationship, Drug; Epilepsy; Extracellular Space; Hippocampus; Interneurons; Kainic Acid; Lidocaine; Neural Inhibition; Neurotoxins; Parvalbumins; Rats; Rats, Wistar; Sodium Channels; Tetrodotoxin | 2000 |
Seizure-induced neuronal death is associated with induction of c-Jun N-terminal kinase and is dependent on genetic background.
Topics: Animals; Cell Death; Epilepsy; Hippocampus; JNK Mitogen-Activated Protein Kinases; Kainic Acid; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neurons; Neurotoxins; Phosphorylation; Proto-Oncogene Proteins c-jun; Seizures; Time Factors | 2000 |
NMDA receptor-dependent plasticity of granule cell spiking in the dentate gyrus of normal and epileptic rats.
Topics: Action Potentials; Animals; Chronic Disease; Dentate Gyrus; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; Magnesium; Male; Neuronal Plasticity; Neurons; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2000 |
Mitochondrial superoxide production in kainate-induced hippocampal damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Aconitate Hydratase; Animals; Cell Death; Deoxyguanosine; DNA Damage; Epilepsy; Free Radical Scavengers; Hippocampus; Kainic Acid; Male; Metalloporphyrins; Mitochondria; Neurons; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; Seizures; Superoxide Dismutase; Superoxides | 2000 |
The effects of GABA(B) receptor activation on spontaneous and evoked activity in the dentate gyrus of kainic acid-treated rats.
Topics: Action Potentials; Animals; Baclofen; Dentate Gyrus; Depression, Chemical; Epilepsy; Excitatory Amino Acid Agonists; Feedback; Kainic Acid; Male; Rats; Rats, Wistar; Receptors, GABA-B | 2001 |
Subnecrotic stereotactic radiosurgery controlling epilepsy produced by kainic acid injection in rats.
Topics: Animals; Brain Mapping; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Necrosis; Radiosurgery; Rats; Rats, Sprague-Dawley | 2000 |
Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Carrier Proteins; Chronic Disease; Dose-Response Relationship, Drug; Down-Regulation; Epilepsy; Extracellular Space; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Organic Anion Transporters; Potassium; Rats; Rats, Wistar; RNA, Messenger; Seizures | 2001 |
In vivo, the direct and seizure-induced neuronal cytotoxicity of kainate and AMPA is modified by the non-competitive antagonist, GYKI 52466.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Cell Death; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Seizures | 2001 |
The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus.
Topics: Animals; Cell Death; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation, Enzymologic; Hippocampus; In Situ Nick-End Labeling; Isoenzymes; Kainic Acid; Lactones; Male; Prostaglandin-Endoperoxide Synthases; Pyramidal Cells; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Sulfones | 2001 |
Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Encephalitis; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression; Gliosis; Hippocampus; In Situ Nick-End Labeling; Interleukin-6; Kainic Acid; Macrophages; Metallothionein; Mice; Mice, Knockout; Microglia; Nerve Degeneration; Oxidative Stress; Seizures; Superoxide Dismutase | 2001 |
Changes in nitric oxide synthesis and epileptic activity in the contralateral hippocampus of rats following intrahippocampal kainate injection.
Topics: Animals; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Epilepsy; Functional Laterality; Hippocampus; Indazoles; Injections, Intraperitoneal; Kainic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 2001 |
Pharmacokinetics and pharmacodynamics of topiramate.
Topics: Adolescent; Anticonvulsants; Calcium Channels; Carbonic Anhydrases; Child; Child, Preschool; Epilepsy; Fructose; gamma-Aminobutyric Acid; Humans; Kainic Acid; Sodium Channels; Topiramate | 2000 |
A spontaneous recurrent seizure-related Rattus NSF gene identified by linker capture subtraction.
Topics: Animals; Base Sequence; Blotting, Northern; Carrier Proteins; Cloning, Molecular; Epilepsy; Excitatory Amino Acid Agonists; Genetic Linkage; Hippocampus; In Situ Hybridization; Kainic Acid; Male; Molecular Sequence Data; N-Ethylmaleimide-Sensitive Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures; Vesicular Transport Proteins | 2001 |
Decreased epileptic susceptibility correlates with neuropeptide Y overexpression in a model of tolerance to excitotoxicity.
Topics: Adaptation, Physiological; Animals; Behavior, Animal; Cell Death; Disease Models, Animal; Disease Susceptibility; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Nerve Degeneration; Neuropeptide Y; Neurotoxins; Pyramidal Cells; Rats; Rats, Wistar | 2001 |
GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis.
Topics: Animals; Biological Transport; Carrier Proteins; Dentate Gyrus; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Kainic Acid; Male; Membrane Proteins; Membrane Transport Proteins; Nipecotic Acids; Organic Anion Transporters; Rats; Rats, Sprague-Dawley; Reference Values; Sclerosis; Temporal Lobe | 2001 |
The changes of AP-1 DNA binding activity and components in hippocampus of seizure-sensitive rat induced by kainate.
Topics: Animals; DNA; DNA-Binding Proteins; Enkephalins; Epilepsy; Hippocampus; Homeodomain Proteins; Kainic Acid; Male; Minor Histocompatibility Antigens; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Replication Protein C; Repressor Proteins; Saccharomyces cerevisiae Proteins | 1998 |
Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury.
Topics: Actins; Animals; Antibodies; Brain; Brain-Derived Neurotrophic Factor; Cell Survival; Cerebral Cortex; Epilepsy; Food Deprivation; Glutamic Acid; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Neostriatum; Nerve Growth Factor; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2001 |
Activation of the nuclear factor-kappaB is a key event in brain tolerance.
Topics: Active Transport, Cell Nucleus; alpha-Linolenic Acid; Animals; Blotting, Western; Brain; Brain Ischemia; Ditiocarb; DNA; DNA-Binding Proteins; Epilepsy; Hippocampus; I-kappa B Proteins; Immunohistochemistry; Ischemic Preconditioning; Kainic Acid; Male; Neurons; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Subunits; Rats; Rats, Wistar; Signal Transduction | 2001 |
Cytokines and seizures.
Topics: Cytokines; Epilepsy; Humans; Interleukin-1; Kainic Acid; Receptors, Interleukin | 2001 |
Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
Topics: 2-Amino-5-phosphonovalerate; Animals; C-Reactive Protein; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Genetic Predisposition to Disease; Immunohistochemistry; Kainic Acid; Limbic System; Male; Mice; Mice, Knockout; Nerve Degeneration; Neurons; Neuroprotective Agents; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Serum Amyloid P-Component | 2001 |
Ibotenate injections into the pre- and parasubiculum provide partial protection against kainate-induced epileptic damage in layer III of rat entorhinal cortex.
Topics: Animals; Convulsants; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Ibotenic Acid; Kainic Acid; Male; Nerve Degeneration; Neurons, Afferent; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2001 |
An experimental study on the course of trans-synaptic propagation of neural activity and plasticity in the hippocampus in kainate-induced epilepsy.
Topics: Animals; Behavior, Animal; Epilepsy; Hippocampus; Immunohistochemistry; In Situ Hybridization; Kainic Acid; Male; Neuronal Plasticity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Synapses; Synapsins | 2001 |
Kainic acid-induced substantia nigra seizure in rats: behavior, EEG and metabolism.
Topics: Action Potentials; Animals; Behavior, Animal; Carbon Radioisotopes; Deoxyglucose; Electroencephalography; Energy Metabolism; Epilepsy; Excitatory Amino Acid Agonists; Glucose; Hippocampus; Kainic Acid; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Substantia Nigra | 2001 |
Do fits really beget fits? The effect of previous epileptic activity on the subsequent induction of the tetanus toxin model of limbic epilepsy in the rat.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Recurrence; Tetanus Toxin | 2001 |
[Effect of scorpion venom on the release of GABA in hippocampus of epileptic rats induced by kainic acid].
Topics: Animals; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Neurons; Random Allocation; Rats; Rats, Sprague-Dawley; Scorpion Venoms; Synaptic Transmission | 1999 |
Dentate hilar mossy cells and somatostatin-containing neurons are immunoreactive for the alpha8 integrin subunit: characterization in normal and kainic acid-treated rats.
Topics: Animals; Cell Adhesion; Cell Communication; Cell Compartmentation; Cell Count; Cell Death; Dendrites; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Extracellular Matrix; Immunohistochemistry; Integrin alpha Chains; Integrins; Kainic Acid; Male; Microscopy, Electron; Mossy Fibers, Hippocampal; Nerve Degeneration; Parvalbumins; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Somatostatin | 2001 |
Anticonvulsive and free radical scavenging activities of Gastrodia elata Bl. in kainic acid-treated rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Brain; Drugs, Chinese Herbal; Electroencephalography; Electromyography; Epilepsy; Excitatory Amino Acid Agonists; Free Radical Scavengers; In Vitro Techniques; Kainic Acid; Lipid Peroxidation; Male; Rats; Rats, Sprague-Dawley | 2001 |
Effect of orally administered guanosine on seizures and death induced by glutamatergic agents.
Topics: Animals; Brain; Caffeine; Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Elapid Venoms; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine; Kainic Acid; Male; Mice; Neuroprotective Agents; Phenobarbital; Phosphodiesterase Inhibitors; Quinolinic Acid; Receptors, Purinergic P1 | 2001 |
Comparative study of hippocampal neuronal loss and in vivo binding of 5-HT1a receptors in the KA model of limbic epilepsy in the rat.
Topics: Aminopyridines; Animals; Binding Sites; Cell Death; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Limbic System; Male; Models, Animal; Neurons; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists | 2001 |
Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hippocampus.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy; Ether; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Methanol; Mice; Mice, Inbred ICR; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Orchidaceae; Phytotherapy; Plant Extracts | 2001 |
Changes in neurofilament protein-immunoreactivity after kainic acid treatment of organotypic hippocampal slice cultures.
Topics: Aging; Animals; Animals, Newborn; Cell Death; Down-Regulation; Epilepsy; Excitatory Amino Acid Agonists; Hippocampus; Immunoblotting; Immunohistochemistry; Kainic Acid; Neurofilament Proteins; Neuronal Plasticity; Neurotoxins; Organ Culture Techniques; Pyramidal Cells; Rats; Rats, Wistar; Up-Regulation | 2001 |
Kainic acid and seizure-induced Fos in subtypes of cerebrocortical neurons.
Topics: Animals; Calcium-Binding Proteins; Cerebral Cortex; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Agonists; Immunohistochemistry; Kainic Acid; Male; Neocortex; Neural Inhibition; Neurons; Neurotoxins; Olfactory Pathways; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 2001 |
[Relation between BDNF and synaptic reorganization of hippocampal mossy fibers].
Topics: Animals; Brain-Derived Neurotrophic Factor; Chromosome Pairing; DNA, Antisense; Epilepsy; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Mossy Fibers, Hippocampal; Rats; Rats, Wistar | 2001 |
Agrin regulates neuronal responses to excitatory neurotransmitters in vitro and in vivo.
Topics: Agrin; Animals; Calcium Channels; Calcium Signaling; Cell Communication; Cells, Cultured; Cerebral Cortex; Electrophysiology; Epilepsy; Excitatory Amino Acid Agonists; Genotype; Glutamic Acid; Heterozygote; Homozygote; In Vitro Techniques; Kainic Acid; Mice; Neurons; Neurotoxins; Nicotine; Nicotinic Agonists; Phenotype; Proto-Oncogene Proteins c-fos; Receptors, Glutamate | 2002 |
Kainate-induced currents in rat cortical neurons in culture are modulated by riluzole.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Cerebral Cortex; Epilepsy; Excitatory Amino Acid Agonists; Fetus; Ion Channels; Kainic Acid; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Riluzole | 2002 |
The expression of Fos following kainic acid-induced seizures is age-dependent.
Topics: Age Factors; Amygdala; Animals; Antibodies; Behavior, Animal; Dentate Gyrus; Epilepsy; Excitatory Amino Acid Agonists; Kainic Acid; Locus Coeruleus; Male; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2002 |
A model of 'epileptic tolerance' for investigating neuroprotection, epileptic susceptibility and gene expression-related plastic changes.
Topics: Animals; Cell Death; Cell Survival; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Gene Expression Regulation; Hippocampus; Ischemic Preconditioning; Kainic Acid; Male; Neuronal Plasticity; Neuropeptide Y; Pyramidal Cells; Rats; Rats, Wistar; Status Epilepticus | 2002 |
Dopamine D2 receptor signaling controls neuronal cell death induced by muscarinic and glutamatergic drugs.
Topics: Acetylcholine; Animals; Behavior, Animal; Cell Death; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists; Female; Genotype; Glutamic Acid; Kainic Acid; Limbic System; Male; Mice; Mice, Knockout; Molecular Sequence Data; Muscarinic Agonists; Nerve Degeneration; Pilocarpine; Receptors, Dopamine D2; Receptors, Muscarinic; RNA, Messenger; Signal Transduction; Synaptic Transmission | 2002 |
Network interactions mediated by new excitatory connections between CA1 pyramidal cells in rats with kainate-induced epilepsy.
Topics: Action Potentials; Animals; Bicuculline; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neural Pathways; Patch-Clamp Techniques; Periodicity; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 2002 |
Local generation of fast ripples in epileptic brain.
Topics: Action Potentials; Animals; Biological Clocks; Brain; Brain Mapping; Chronic Disease; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy; Evoked Potentials; Feedback; GABA Antagonists; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Microelectrodes; Neural Inhibition; Perforant Pathway; Rats; Rats, Sprague-Dawley; Reaction Time | 2002 |
Volumetric structural magnetic resonance imaging (MRI) of the rat hippocampus following kainic acid (KA) treatment.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Astrocytes; Avian Proteins; Basigin; Benzoxazines; Blood Proteins; Brain Mapping; Cell Count; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Gyrus Cinguli; Hippocampus; Immunohistochemistry; Kainic Acid; Lateral Ventricles; Magnetic Resonance Imaging; Male; Membrane Glycoproteins; Microglia; Nerve Degeneration; Organic Chemicals; Oxazines; Rats; Rats, Sprague-Dawley | 2002 |
[The role of somatostatin in area CA1 of rat hippocampus in experimental epilepy].
Topics: Animals; Electrophysiology; Epilepsy; Hippocampus; Kainic Acid; Male; Microinjections; Penicillins; Rats; Rats, Sprague-Dawley; Somatostatin | 2000 |
Increased afterdischarge threshold during kindling in epileptic rats.
Topics: Animals; Electric Stimulation; Electric Stimulation Therapy; Epilepsy; Epilepsy, Temporal Lobe; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Membrane Potentials; Neurons; Neurotoxins; Perforant Pathway; Rats; Rats, Sprague-Dawley; Reaction Time; Synaptic Transmission; Up-Regulation | 2002 |
Early induction of secretoneurin expression following kainic acid administration at convulsant doses in the rat and gerbil hippocampus.
Topics: Animals; Calbindin 2; Calbindins; Chromogranins; Convulsants; Epilepsy; Excitatory Amino Acid Agonists; GABA Antagonists; GABA-B Receptor Antagonists; Gerbillinae; Hippocampus; Immunohistochemistry; Kainic Acid; Neuropeptides; Organophosphorus Compounds; Parvalbumins; Phosphinic Acids; Proteins; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Secretogranin II | 2002 |
Increased vulnerability to kainate-induced seizures in utrophin-knockout mice.
Topics: Animals; Cell Count; Cell Size; Cell Survival; Cytoskeletal Proteins; Dentate Gyrus; Dystrophin; Epilepsy; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Female; Genetic Predisposition to Disease; Genotype; Hypertrophy; Immunohistochemistry; Kainic Acid; Male; Membrane Proteins; Mice; Mice, Knockout; Nerve Degeneration; Neurons; RNA, Messenger; Up-Regulation; Utrophin | 2002 |
Electrophysiological, behavioral and metabolical features of globus pallidus seizures induced by a microinjection of kainic acid in rats.
Topics: Action Potentials; Animals; Behavior, Animal; Carbon Radioisotopes; Deoxyglucose; Energy Metabolism; Epilepsy; European Union; Excitatory Amino Acid Agonists; Functional Laterality; Globus Pallidus; Glucose; Kainic Acid; Male; Movement Disorders; Nerve Degeneration; Neural Pathways; Neurons; Rats; Rats, Wistar | 2002 |
Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures.
Topics: Action Potentials; Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electric Stimulation; Electroshock; Epilepsy; Excitatory Amino Acid Antagonists; Humans; In Vitro Techniques; Isoquinolines; Kainic Acid; Limbic System; Male; Mice; Pilocarpine; Rats; Rats, Wistar; Receptors, Kainic Acid; Substrate Specificity; Treatment Outcome | 2002 |
Downregulation of kainate receptors in the hippocampus following repeated seizures in immature rats.
Topics: Animals; Animals, Newborn; Binding Sites; Down-Regulation; Drug Administration Schedule; Epilepsy; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; Kainic Acid; Learning; Male; Memory; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Synaptic Transmission | 2002 |
Relation between release of taurine and phosphoethanolamine and osmoregulation in experimental epilepsy.
Topics: Amino Acids; Amygdala; Animals; Brain; Dialysis; Epilepsy; Ethanolamines; Hippocampus; Homeostasis; Kainic Acid; Limbic System; Neural Inhibition; Rabbits; Rats; Status Epilepticus; Synaptic Transmission; Taurine; Water-Electrolyte Balance | 1992 |
Methohexitone antagonises kainate and epileptiform activity in rat neocortical slices.
Topics: Action Potentials; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Epilepsy; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Methohexital; Quinoxalines; Rats; Receptors, Glutamate; Receptors, Kainic Acid | 1992 |
Long-term potentiation and sprouting of mossy fibers produced by brief episodes of hyperactivity.
Topics: Afferent Pathways; Animals; Axons; Brain Mapping; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Microscopy, Electron; Nerve Fibers; Nerve Net; Nerve Regeneration; Neuronal Plasticity; Potassium Channels; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1992 |
Protection from kainic acid neuropathological syndrome by NMDA receptor antagonists: effect of MK-801 and CGP 39551 on neurotransmitter and glial markers.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Epilepsy; Kainic Acid; Male; Neuroglia; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Syndrome | 1992 |
Excitatory neurotransmitters in the lateral habenula and pedunculopontine nucleus of rat modulate limbic seizures induced by pilocarpine.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Epilepsy; Glutamine; Kainic Acid; Limbic System; Male; N-Methylaspartate; Neurotransmitter Agents; Pilocarpine; Pons; Rats; Rats, Wistar; Thalamus | 1992 |
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Amygdala; Animals; Bicuculline; Brain Mapping; Carbachol; Dominance, Cerebral; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Ibotenic Acid; Kainic Acid; Limbic System; Muscimol; Quisqualic Acid; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1992 |
Correlations between local cerebral glucose utilization and electroclinical observations in kainic acid-induced visual cortical seizures in the rat.
Topics: Animals; Autoradiography; Brain; Deoxyglucose; Epilepsy; Kainic Acid; Male; Rats; Rats, Wistar; Visual Cortex | 1992 |
Functional and histological consequences of quinolinic and kainic acid-induced seizures on hippocampal somatostatin neurons.
Topics: Animals; Cell Survival; Cysteamine; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Neurons; Quinolinic Acid; Quinolinic Acids; Rats; Somatostatin | 1991 |
The contribution of non-NMDA and NMDA receptors to graded bursting activity in the CA1 region of the hippocampus in a chronic model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Chronic Disease; Electric Stimulation; Electrophysiology; Epilepsy; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Epileptic manifestations and influence on sleep in the baboon Papio papio.
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Tonic-Clonic; Kainic Acid; Limbic System; Papio; Pentylenetetrazole; Photic Stimulation; Sleep Stages; Status Epilepticus | 1991 |
Seizures increase acetylcholine and choline concentrations in rat brain regions.
Topics: Acetylcholine; Animals; Brain; Choline; Epilepsy; Kainic Acid; Lithium; Male; Pilocarpine; Rats; Rats, Inbred Strains | 1991 |
Sensitivity of hippocampal neurones to kainic acid, and antagonism by kynurenate.
Topics: Animals; Colchicine; Epilepsy; Hippocampus; In Vitro Techniques; Iontophoresis; Kainic Acid; Kynurenic Acid; Male; Neurons; Pyramidal Tracts; Rabbits; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereotaxic Techniques | 1990 |
N-[1-(2-thienyl)cyclohexyl]-piperidine (TCP) does not block kainic acid-induced status epilepticus but reduces secondary hippocampal damage.
Topics: Animals; Epilepsy; Hippocampus; Kainic Acid; Male; Neurons; Phencyclidine; Pyramidal Tracts; Rats; Rats, Inbred Strains; Reference Values | 1991 |
Sprouting of mossy fibers in the hippocampus of epileptic human and rat.
Topics: Animals; Binding Sites; Child; Epilepsy; Hippocampus; Humans; Kainic Acid; Kindling, Neurologic; Neuronal Plasticity; Rats; Rats, Inbred Strains | 1990 |
Opioid involvement in epileptogenic and neurovisceral activity.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Digestive System; Enkephalin, Leucine; Enkephalin, Methionine; Epilepsy; Kainic Acid; Male; Mice; Naloxone; Nervous System; Pyrrolidines; Receptors, Opioid | 1990 |
Decrease in hippocampal [3H]vinylidene kainic acid binding in genetically epilepsy-prone rats.
Topics: Animals; Autoradiography; Epilepsy; Glutamates; Hippocampus; Kainic Acid; Kinetics; Organ Specificity; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Reference Values; Tritium | 1990 |
Effect of chronic cervical sympathectomy on local cerebral blood flow during limbic seizures in rat.
Topics: Animals; Cerebral Cortex; Cerebrovascular Circulation; Epilepsy; Ganglia, Sympathetic; Ganglionectomy; Hippocampus; Kainic Acid; Limbic System; Male; Rats; Rats, Inbred Strains; Time Factors | 1990 |
[Effects of destruction and activation of limbic structures on formation of convulsive and emotional disorders during picrotoxin kindling].
Topics: Amygdala; Animals; Behavior, Animal; Emotions; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Picrotoxin; Rats; Rats, Inbred Strains | 1990 |
Hippocampal plasticity in the kindling model of epilepsy in rats.
Topics: Amygdala; Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Neuronal Plasticity; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, Neurotransmitter; Reference Values | 1989 |
Hippocampal plasticity in childhood epilepsy.
Topics: Adolescent; Autoradiography; Child; Child, Preschool; Epilepsy; Hippocampus; Humans; Infant; Kainic Acid; Neuronal Plasticity; Receptors, Kainic Acid; Receptors, Neurotransmitter; Reference Values; Tritium | 1989 |
Kainic acid-induced seizures: potentiation by alpha-methyl-p-tyrosine.
Topics: alpha-Methyltyrosine; Animals; Clonidine; Diazepam; Dopamine; Epilepsy; Kainic Acid; Male; Methyltyrosines; Neurons; Norepinephrine; Rats; Rats, Inbred Strains | 1989 |
Extracellular studies on the role of N-methyl-D-aspartate receptors in epileptiform activity recorded from the kainic acid-lesioned hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Epilepsy; Hippocampus; In Vitro Techniques; Kainic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Transmission; Valine | 1986 |
Excitatory amino acids and the blood-brain barrier (BBB).
Topics: Amino Acids; Animals; Blood-Brain Barrier; Epilepsy; Humans; Kainic Acid; Neurotransmitter Agents | 1986 |
On the role of seizure activity and endogenous excitatory amino acids in mediating seizure-associated hippocampal damage.
Topics: Acetylcholine; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cell Survival; Dendrites; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Kainic Acid; Neurotransmitter Agents; Seizures; Time Factors | 1986 |
The expression of N-methyl-D-aspartate-receptor-mediated component during epileptiform synaptic activity in hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Anticonvulsants; Epilepsy; Hippocampus; In Vitro Techniques; Kainic Acid; Magnesium; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Valine | 1987 |
Concomitant increase of somatostatin, neuropeptide Y and glutamate decarboxylase in the frontal cortex of rats with decreased seizure threshold.
Topics: Animals; Cysteamine; Dose-Response Relationship, Drug; Epilepsy; Frontal Lobe; Glutamate Decarboxylase; Kainic Acid; Kindling, Neurologic; Male; Neuropeptide Y; Pentylenetetrazole; Rats; Rats, Inbred Strains; Somatostatin; Time Factors | 1988 |
Quinoxalinediones selectively block quisqualate and kainate receptors and synaptic events in rat neocortex and hippocampus and frog spinal cord in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anura; Cerebral Cortex; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Neuromuscular Depolarizing Agents; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, Neurotransmitter; Spinal Cord; Synapses | 1988 |
Baclofen suppresses bursting activity induced in hippocampal slices by differing convulsant treatments.
Topics: Action Potentials; Animals; Anticonvulsants; Baclofen; Bicuculline; Convulsants; Epilepsy; Female; Hippocampus; In Vitro Techniques; Kainic Acid; Potassium; Rats; Receptors, GABA-A | 1986 |
Na+ fluxes as a tool to identify anticonvulsant antagonists of neuroexcitation.
Topics: Animals; Anticonvulsants; Dipeptides; Dose-Response Relationship, Drug; Epilepsy; Glutamates; In Vitro Techniques; Kainic Acid; Mice; Motor Activity; Muscle Contraction; Receptors, Neurotransmitter; Sodium; Structure-Activity Relationship | 1986 |
Excitatory amino acid antagonists as novel anticonvulsants.
Topics: Amino Acids, Dicarboxylic; Animals; Anticonvulsants; Aspartic Acid; Epilepsy; Glutamates; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Nervous System Diseases; Oxadiazoles; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface; Structure-Activity Relationship | 1986 |
Excitatory amino acids and divalent cations in the kindling model of epilepsy.
Topics: Animals; Aspartic Acid; Calcium; Calcium-Binding Proteins; Cations, Divalent; Epilepsy; Glutamates; Hippocampus; Kainic Acid; Kindling, Neurologic; Receptors, Neurotransmitter; Synaptic Transmission; Time Factors; Zinc | 1986 |
Selective and non-selective seizure related brain damage produced by kainic acid.
Topics: Animals; Brain; Brain Mapping; Deoxyglucose; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Kainic Acid; Limbic System; Receptors, Kainic Acid; Receptors, Neurotransmitter; Seizures | 1986 |
Quinolinic acid: a pathogen in seizure disorders?
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Cholinergic Fibers; Convulsants; Epilepsy; Kainic Acid; Ligands; Oxidoreductases; Pentosyltransferases; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1986 |
Effect of mannitol treatment on brain neurotransmitter markers in kainic acid-induced epilepsy.
Topics: Animals; Brain Damage, Chronic; Choline O-Acetyltransferase; Epilepsy; Glutamate Decarboxylase; Kainic Acid; Limbic System; Male; Mannitol; Norepinephrine; Rats; Rats, Inbred Strains | 1987 |
On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat.
Topics: Amino Acids; Animals; Dialysis; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Potentials; Female; Hippocampus; Kainic Acid; Kindling, Neurologic; Male; Rats; Rats, Inbred Strains | 1988 |
Pentylenetetrazol seizure threshold and extracellular levels of cortical amino acids in taurine-deficient kittens.
Topics: Amino Acids; Animals; Cats; Cerebral Cortex; Epilepsy; Extracellular Space; Female; Kainic Acid; Male; Pentylenetetrazole; Taurine | 1987 |
Effects of intrahippocampal injection of kainic acid on estrous cycle in rats.
Topics: Animals; Epilepsy; Estrus; Female; Hippocampus; Injections; Kainic Acid; Progesterone; Rats; Rats, Inbred Strains | 1987 |
Long-term alterations in amino acid-induced ionic conductances in chronic epilepsy.
Topics: Amino Acids; Animals; Aspartic Acid; Calcium; Cobalt; Electric Conductivity; Epilepsy; Glutamates; Kainic Acid; Motor Cortex; N-Methylaspartate; Oxadiazoles; Pyramidal Tracts; Quisqualic Acid; Rats; Sodium | 1986 |
Alterations in extracellular amino acids and Ca2+ following excitotoxin administration and during status epilepticus.
Topics: Amino Acids; Animals; Aspartic Acid; Bicuculline; Calcium; Epilepsy; Ethanolamines; Extracellular Space; Glutamates; Hippocampus; Kainic Acid; N-Methylaspartate; Rabbits; Synaptic Membranes; Synaptosomes; Taurine; Tetrodotoxin | 1986 |
Excitatory amino acids and epilepsy-induced changes in extracellular space size.
Topics: Animals; Aspartic Acid; Cats; Epilepsy; Extracellular Space; Hippocampus; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuroglia; Oxadiazoles; Potassium; Quisqualic Acid; Somatosensory Cortex; Water-Electrolyte Balance | 1986 |
Wet dog shakes in limbic versus generalized seizures.
Topics: Amygdala; Animals; Disease Models, Animal; Epilepsy; Hippocampus; Kainic Acid; Kindling, Neurologic; Limbic System; Oxadiazoles; Quisqualic Acid; Rats | 1987 |
Hippocampal, granule cell and CA3-4 lesions impair formation of a place learning-set in the rat and induce reflex epilepsy.
Topics: Animals; Brain Damage, Chronic; Colchicine; Epilepsy; Hippocampus; Kainic Acid; Learning; Male; Parietal Lobe; Rats; Rats, Inbred Strains; Reaction Time; Spatial Behavior | 1987 |
Excitotoxic mechanisms of epileptic brain damage.
Topics: Administration, Topical; Amygdala; Animals; Axons; Biomechanical Phenomena; Brain; Choline; Cholinesterase Inhibitors; Convulsants; Corpus Striatum; Epilepsy; Folic Acid; Injections; Kainic Acid; Lithium; Motor Cortex; Neural Pathways; Neurotoxins; Piperidines; Rats; Seizures; Somatosensory Cortex | 1986 |
Electrocerebral and behavioural analysis of systemic kainic acid-induced epilepsy in the rat.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Epilepsy; Kainic Acid; Male; Rats; Rats, Inbred Strains | 1986 |
Electrophysiology of epileptic tissue: what pathologies are epileptogenic?
Topics: Action Potentials; Animals; Cerebral Cortex; Epilepsy; Epilepsy, Temporal Lobe; Gliosis; Guinea Pigs; Hippocampus; Humans; In Vitro Techniques; Kainic Acid; Kindling, Neurologic; Neural Inhibition | 1986 |
Pathophysiological aspects of blood-brain barrier permeability in epileptic seizures.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Cerebrovascular Circulation; Endothelium; Epilepsy; Kainic Acid; Methionine Sulfoximine; Pentylenetetrazole; Pyridoxine; Rabbits; Seizures | 1986 |
Damage induced by systemic kainic acid in rats is dependent upon seizure activity--a behavioral and morphological study.
Topics: Animals; Behavior, Animal; Brain; Drinking Behavior; Epilepsy; Feeding Behavior; Injections, Intraperitoneal; Kainic Acid; Male; Motor Activity; Rats; Rats, Inbred F344; Time Factors | 1986 |
Epileptogenic effect of intracortically applied kainic acid in cats.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Electroencephalography; Epilepsy; Kainic Acid; Male; Pyridones | 1985 |
Do kainate-lesioned hippocampi become epileptogenic?
Topics: Action Potentials; Animals; Epilepsy; Hippocampus; In Vitro Techniques; Kainic Acid; Neural Inhibition; Neuronal Plasticity; Pyrrolidines; Rats; Synapses | 1985 |
Incongruence of regional cerebral blood flow increase and blood-brain barrier opening in rabbits at the onset of seizures induced by bicuculline, methoxypyridoxine, and kainic acid.
Topics: Animals; Bicuculline; Blood Pressure; Blood-Brain Barrier; Brain; Epilepsy; Kainic Acid; Male; Nicotine; Pyridoxine; Rabbits; Regional Blood Flow | 1985 |
Role of the pulvinar-lateralis posterior nucleus complex (P-LP) in the experimental epilepsy of the cat.
Topics: Animals; Cats; Epilepsy; Female; Kainic Acid; Male; Penicillins; Thalamic Nuclei | 1985 |
Electroencephalographic activity after kainic and ibotenic acid injections in the amygdaloid complex of rats.
Topics: Amygdala; Animals; Behavior, Animal; Electroencephalography; Epilepsy; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Male; Oxazoles; Pyrrolidines; Rats; Rats, Inbred Strains; Time Factors | 1985 |